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Dr Samuel Janes

  • Telephone:

    02076796975

  • Fax:

    02076796973

  • Email:

    s.janes@ucl.ac.uk

  • Address:

    Lungs for Living Research Centre Division of Medicine, Rayne Building,
    University College london, 5 University Street,
    London,
    WC1E 6JF

  • Appointments:

    Reader in Respiratory Medicine, Internal Medicine, Div of Medicine

Summary

Medical Training
I trained in medicine at Charing Cross and Westminster Medical School and completed my MBBS and BSc degrees.  I went on to train as a respiratory physician in the North West Thames region of London working in five of London's hospitals including Harfield transplant centre, Hammersmith and St Mary's Hospital.  I completed an MSc (Distinction) at the Royal Brompton.

Research Training
While at Hammersmith, I became progressively more interested in cancer biology and then joined Fiona Watt's laboratory as an MRC Training Fellow at the then Imperial Cancer Research Fund labs at Lincoln's Inn Fields - now CRUK London Research Institute.  Here I completed a PhD on the role of integrin cell adhesion molecules and their control of apoptosis and differentiation.  I went on to perform an 18 month CRUK post-doctoral period with Fiona and then won an MRC Clinician Scientist Fellowship to start my own group with Geoff Laurent's Centre for Respiratory Research.  My Laboratory focus became the role of stem cells in lung disease pathogenesis and treatments.

Current Research

In 2011, I won my Wellcome Senior Fellowship in Clinical Sciences that underpins my laboratory.  Other funders of my work include the MRC, ESPRC, NIHR, Rosetrees Trust, Roy Castle Lung Foundation and Johnson and Johnson.  In 2012, I formed the Lungs for Living patient information and fund raising group based within UCLH Charitable Foundation and launched the Lungs for Living Research Centre focussing on researching early lung cancer and the role of stem cells in its formation and treatments.

I work as a Consultant in Respiratory Medicine with and interest in Lung Cancer and interventional bronchoscopy.  I run a number of clinical trials focussed on improving diagnostic techniques in lung cancer and other respiratory disorders.  My aim is to improve the patient pathways to treatment.  I am Director of Lung Cancer for North Central and North East London (London Cancer) with the remit to diagnose lung cancer earlier, improve survival and patient experience.


Research Summary

My laboratory work focuses on three questions

  1. What is the role of airway stem cells in the formation of lung cancer and other lung diseases?
  2. What molecular changes cause pre-invasive lung cancer lesions and what makes them progress?
  3. Can we use exogenous (bone marrow) stem cells as a novel therapy for lung cancers including mesothelioma?

My Clinical Research asks:

  1. Can we improve diagnostic accuracy for lung cancer?
  2. Can we improve the speed of diagnosis and staging?
  3. Can we diagnose lung cancer earlier?

My team works within the Lungs for Living Research Centre, which is closely aligned with the Centre for Inflammation and Tissue Repair directed by Rachel Chambers.

Research Activities

  • Gene and Cellular Therapy of Haematological Malignancies
  • Understanding the role of stem cells in cancer development

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Navani N,Janes SM,REMEDY Trial Management Group (2013) Reply: endobronchial ultrasound–guided transbronchial needle aspiration versus cervical mediastinoscopy: case selection is needed to maintain clinical as well as cost benefits. Am J Respir Crit Care Med, 187(4), 449.
  2. Brazil SV,Brown JM,McAsey D,Nankivell M,Lawrence DR,George JP,Janes SM,Navani N (2013) Incidental discovery is the prevalent referral pathway to surgery for early stage lung cancer LUNG CANCER, 79, S35 - S35.
  3. Mitchell N,Kalber TL,Cooper MS,Sunassee K,Chalker SL,Shaw KP,Ordidge KL,Badar A,Janes SM,Blower PJ,Lythgoe MF,Hailes HC,Tabor AB (2013) Incorporation of paramagnetic, fluorescent and PET/SPECT contrast agents into liposomes for multimodal imaging. Biomaterials, 34(4), 1179 - 1192. 10.1016/j.biomaterials.2012.09.070.
  4. Lu L,Teixeira VH,Yuan Z,Graham TA,Endesfelder D,Kolluri K,Al-Juffali N,Hamilton N,Nicholson AG,Falzon M,Kschischo M,Swanton C,Wright NA,Carroll B,Watt FM,George JP,Jensen KB,Giangreco A,Janes SM (2013) LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development. J Pathol, 229(4), 608 - 620. 10.1002/path.4148.
  5. Kalber TL,Campbell-Washburn AE,Siow BM,Sage E,Price AN,Ordidge KL,Walker-Samuel S,Janes SM,Lythgoe MF (2013) Primed infusion with delayed equilibrium of Gd.DTPA for enhanced imaging of small pulmonary metastases. PLoS One, 8(1), e54903. 10.1371/journal.pone.0054903.
  6. Ntolios P,Janes SM (2013) Mesenchymal stem cell therapy for lung diseases: oasis or mirage? Respiration, 85(4), 279 - 280. 10.1159/000346642.
  7. Navani N,Janes SM (2013) Reply: lung cancer diagnosis and staging centers. Am J Respir Crit Care Med, 187(4), 451.
  8. Win T,Miles K,Janes SM,Ganeshan B,Shastry M,Endozo R,Meagher M,Shortman RI,Wan S,Kayani I,Ell P,Groves AM (2013) Tumor Heterogeneity as measured on the CT component of PET/CT Predicts Survival in Patients with Potentially Curable Non-Small Cell Lung Cancer. Clin Cancer Res. 10.1158/1078-0432.CCR-12-1307.
  9. Brown J,Woolhouse I,Harrison R,Jeebun V,Munavvar M,Ng B,Falzon M,Kocjan G,Rintoul R,Janes S,Navani N (2012) Suitability of EBUS-TBNA specimens for the subtyping and genotyping of non-small cell lung cancer: a multi-centre pragmatic implementation study of 774 patients LUNG CANCER, 75, S18 - S18.
  10. Navani N,Lawrence DR,Kolvekar S,Hayward M,McAsey D,Kocjan G,Falzon M,Capitanio A,Shaw P,Morris S,Omar RZ,Janes SM,REMEDY Trial Investigators (2012) Endobronchial ultrasound-guided transbronchial needle aspiration prevents mediastinoscopies in the diagnosis of isolated mediastinal lymphadenopathy: a prospective trial. Am J Respir Crit Care Med, 186(3), 255 - 260. 10.1164/rccm.201203-0393OC.
  11. Navani N,Brown JM,Nankivell M,Woolhouse I,Harrison RN,Jeebun V,Munavvar M,Ng BJ,Rassl DM,Falzon M,Kocjan G,Rintoul RC,Nicholson AG,Janes SM (2012) Suitability of endobronchial ultrasound-guided transbronchial needle aspiration specimens for subtyping and genotyping of non-small cell lung cancer: a multicenter study of 774 patients. Am J Respir Crit Care Med, 185(12), 1316 - 1322. 10.1164/rccm.201202-0294OC.
  12. Giangreco A,Lu L,Vickers C,Teixeira VH,Groot KR,Butler CR,Ilieva EV,George PJ,Nicholson AG,Sage EK,Watt FM,Janes SM (2012) β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition. J Pathol, 226(4), 575 - 587. 10.1002/path.3962.
  13. Smith LJ,Lawrence DR,Kayani I,Capitanio A,Falzon M,Janes SM,Navani N (2012) Pulmonary mass in a 19-year-old male. Inflammatory myofibroblastic tumour. Thorax, 67(5), 468 - 470. 10.1136/thoraxjnl-2011-200732.
  14. Brown J,Marechal A,Navani N,George J,Rich P,Janes S (2012) Infrared spectral signatures of respiratory carcinogenesis: a pilot study LUNG CANCER, 75, S18 - S19.
  15. Ordidge KL,Duffy BA,Wells JA,Kalber TL,Janes SM,Lythgoe MF (2012) Imaging the paediatric lung: what does nanotechnology have to offer? Paediatr Respir Rev, 13(2), 84 - 88. 10.1016/j.prrv.2011.07.001.
  16. Shastry M,Miles KA,Win T,Janes SM,Endozo R,Meagher M,Ell PJ,Groves AM (2012) Integrated 18F-Fluorodeoxyglucose-Positron Emission Tomography/dynamic Contrast-enhanced Computed Tomography To Phenotype Non-small Cell Lung Carcinoma. Mol Imaging, 11(5), 1 - 8.
  17. Elliott MJ,De Coppi P,Speggiorin S,Roebuck D,Butler CR,Samuel E,Crowley C,McLaren C,Fierens A,Vondrys D,Cochrane L,Jephson C,Janes S,Beaumont NJ,Cogan T,Bader A,Seifalian AM,Hsuan JJ,Lowdell MW,Birchall MA (2012) Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study Lancet, 380, 994 - 1000. 10.1016/S0140-6736(12)60737-5.
  18. Shastry M,Miles KA,Win T,Janes SM,Endozo R,Meagher M,Ell PJ,Groves AM (2012) Integrated 18F-fluorodeoxyglucose-positron emission tomography/dynamic contrast-enhanced computed tomography to phenotype non-small cell lung carcinoma. Mol Imaging, 11(5), 353 - 360.
  19. McNulty K,Janes SM (2012) Stem cells and pulmonary fibrosis: cause or cure? Proc Am Thorac Soc, 9(3), 164 - 171. 10.1513/pats.201201-010AW.
  20. Navani N,Kon OM,Janes SM (2012) CT screening for lung cancer: so near, yet so far response THORAX, 67(7), 652 - 652. 10.1136/thoraxjnl-2011-201267.
  21. Giangreco A,Lu L,Vickers C,Teixeira VH,Groot KR,Butler CR,Ilieva EV,George PJ,Nicholson AG,Sage EK,Watt FM,Janes SM (2012) β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition Journal of Pathology, 226(4), 575 - 587.
  22. Reagan MR,Seib FP,McMillin DW,Sage EK,Mitsiades CS,Janes SM,Ghobrial IM,Kaplan DL (2012) Stem Cell Implants for Cancer Therapy: TRAIL-Expressing Mesenchymal Stem Cells Target Cancer Cells In Situ. J Breast Cancer, 15(3), 273 - 282. 10.4048/jbc.2012.15.3.273.
  23. McNulty K,Sage EK,Alexander R,Scotton CJ,Janes SM (2012) EXOGENOUS MACROPHAGES ARE RETAINED IN MOUSE LUNGS AFTER INJURY AND TARGET THERAPEUTIC TRANSGENES TO THE INJURED LUNG PARENCHYMA THORAX, 67, A62 - A62. 10.1136/thoraxjnl-2012-202678.135.
  24. Sage EK,McNulty K,Kolluri K,Giangreco A,Janes SM (2012) MSCTRAIL AS A NOVEL CELLULAR THERAPY FOR MALIGNANT MESOTHELIOMA THORAX, 67, A1 - A1. 10.1136/thoraxjnl-2012-202678.002.
  25. Giangreco A,Lu L,Mazzatti DJ,Spencer-Dene B,Nye E,Teixeira VH,Janes SM (2011) Myd88 deficiency influences murine tracheal epithelial metaplasia and submucosal gland abundance. J Pathol, 224(2), 190 - 202. 10.1002/path.2876.
  26. Shastry M,Miles KA,Win T,Janes SM,Endozo R,Meagher M,Ell PJ,Groves AM (2011) Integrated 18F-Fluorodeoxyglucose-Positron Emission Tomography/dynamic Contrast-enhanced Computed Tomography To Phenotype Non-small Cell Lung Carcinoma. Mol Imaging, 11(5), 1 - 8.
  27. Navani N,Costello D,Brown JM,Sandhu G,Janes SM,George J (2011) A rare asthma mimic exposed by basic physiology. QJM, 104(1), 59 - 60. 10.1093/qjmed/hcq054.
  28. Sage E,Kolluri K,Giangreco A,Janes S (2011) MESENCHYMAL STEM CELLS EXPRESSING TRAIL INDUCE APOPTOSIS IN MALIGNANT PLEURAL MESOTHELIOMA THORAX, 66, A29 - A29. 10.1136/thoraxjnl-2011-201054b.60.
  29. Giangreco A,Lu L,Mazzatti D,Spencer-Dene B,Nye E,Teixeira V,Janes S (2011) MYD88 DEFICIENCY INFLUENCES MURINE TRACHEAL EPITHELIAL METAPLASIA AND SUBMUCOSAL GLAND ABUNDANCE THORAX, 66, A19 - A20. 10.1136/thoraxjnl-2011-201054b.37.
  30. Navani N,Lawrence DR,Kolvekar S,McAsey D,Omar R,Morris S,Janes SM (2011) EBUS-TBNA PREVENTS MEDIASTINOSCOPIES IN PATIENTS WITH ISOLATED MEDIASTINAL LYMPHADENOPATHY: A PROSPECTIVE CLINICAL TRIAL AND COST MINIMISATION ANALYSIS THORAX, 66, A27 - A28. 10.1136/thoraxjnl-2011-201054b.56.
  31. Giangreco A,Lu L,Vickers C,Ilieva E,Groot K,George J,Nicholson A,Sage E,Watt F,Janes S (2011) BETA-CATENIN DETERMINES TRACHEAL CELL FATE AND SQUAMOUS LUNG CANCER PROGRESSION BY MODULATING INTERCELLULAR ADHESIVENESS THORAX, 66, A29 - A29. 10.1136/thoraxjnl-2011-201054b.58.
  32. Smith LJE,Kayani I,Bomanji J,Groves AM,Carroll B,Navani N,George JP,Janes SM (2011) COMBINED 18F-FDG PET/CT AS PART OF A SURVEILLANCE PROGRAMME OF PATIENTS WITH NEWLY DIAGNOSED PRE-INVASIVE ENDOBRONCHIAL LESIONS DETECTS SYNCHRONOUS LUNG CANCERS THORAX, 66, A132 - A133. 10.1136/thoraxjnl-2011-201054c.161.
  33. Navani N,Nankivell M,Nadarajan P,Pereira SP,Kocjan G,Janes SM (2011) The learning curve for EBUS-TBNA. Thorax, 66(4), 352 - 353. 10.1136/thx.2010.146407.
  34. Hunziker L,Benitah SA,Braun KM,Jensen K,McNulty K,Butler C,Potton E,Nye E,Boyd R,Laurent G,Glogauer M,Wright NA,Watt FM,Janes SM (2011) Rac1 deletion causes thymic atrophy. PLoS One, 6(4), e19292. 10.1371/journal.pone.0019292.
  35. McNulty K,Scotton CJ,Sage EK,Chambers RC,Janes SM (2011) MACROPHAGES AS VEHICLES FOR DELIVERING CELL THERAPY TO INJURED LUNG THORAX, 66, A36 - A36. 10.1136/thoraxjnl-2011-201054b.73.
  36. McCaughan F,Pipinikas CP,Janes SM,George PJ,Rabbitts PH,Dear PH (2011) Genomic evidence of pre-invasive clonal expansion, dispersal and progression in bronchial dysplasia. J Pathol, 224(2), 153 - 159. 10.1002/path.2887.
  37. Navani N,Nankivell M,Woolhouse I,Harrison RN,Munavvar M,Oltmanns U,Falzon M,Kocjan G,Rintoul RC,Janes SM (2011) Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrathoracic lymphadenopathy in patients with extrathoracic malignancy: a multicenter study. J Thorac Oncol, 6(9), 1505 - 1509. 10.1097/JTO.0b013e318223c3fe.
  38. Navani N,Molyneaux PL,Breen RA,Connell DW,Jepson A,Nankivell M,Brown JM,Morris-Jones S,Ng B,Wickremasinghe M,Lalvani A,Rintoul RC,Santis G,Kon OM,Janes SM (2011) Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study. Thorax, 66(10), 889 - 893. 10.1136/thoraxjnl-2011-200063.
  39. Navani N,Booth HL,Kocjan G,Falzon M,Capitanio A,Brown JM,Porter JC,Janes SM (2011) Combination of endobronchial ultrasound-guided transbronchial needle aspiration with standard bronchoscopic techniques for the diagnosis of stage I and stage II pulmonary sarcoidosis. Respirology, 16(3), 467 - 472. 10.1111/j.1440-1843.2011.01933.x.
  40. Spiro SG,Tanner NT,Silvestri GA,Janes SM,Lim E,Vansteenkiste JF,Pirker R (2010) Lung cancer: Progress in diagnosis, staging and therapy RESPIROLOGY, 15(1), 44 - 50. 10.1111/j.1440-1843.2009.01674.x.
  41. Naqvi J,Navani N,Saeed S,Shastry M,Groves A,Shaw P,Lawrence D,Kolvekar S,Hayward M,Janes S (2010) A RETROSPECTIVE STUDY OF DISEASE RECURRENCE POST THORACOTOMY FOR NON-SMALL CELL LUNG CANCER THORAX, 65, A170 - A171. 10.1136/thx.2010.151068.23.
  42. Alcada J,Navani N,Taylor M,Shaw P,Miller RF,Janes SM (2010) HIGH PREVALENCE OF MALIGNANCY IN HIV INFECTED PATIENTS WITH ENLARGED MEDIASTINAL LYMPHADENOPATHY THORAX, 65, A169 - A170. 10.1136/thx.2010.151068.21.
  43. Navani N,Naqvi J,Saeed S,Nankivell M,Shastry M,Groves A,Shaw P,Hayward M,Kolvekar S,Lawrence D,Janes SM (2010) A retrospective study of disease recurrence post thoracotomy for non-small cell lung cancer LUNG CANCER, 67, S38 - S39.
  44. Loebinger MR,Janes SM (2010) Stem cells as vectors for antitumour therapy. Thorax, 65(4), 362 - 369. 10.1136/thx.2009.128025.
  45. Loebinger MR,Sage EK,Davies D,Janes SM (2010) TRAIL-expressing mesenchymal stem cells kill the putative cancer stem cell population. Br J Cancer, 103(11), 1692 - 1697. 10.1038/sj.bjc.6605952.
  46. Parcell KL,Kalber TL,Walker-Samuel S,Southern P,Pankhurst QA,Lythgoe MF,Janes SM (2010) BIMODAL IRON OXIDE NANOPARTICLES FOR HYPERTHERMIA THERAPY AND MR IMAGING IN CANCER THORAX, 65, A41 - A42. 10.1136/thx.2010.150938.40.
  47. Navani N,Booth HL,Sheinman B,Johnson N,Janes S (2009) COMBINING EBUS-TBNA WITH STANDARD BRONCHOSCOPIC TECHNIQUES FOR THE DIAGNOSIS OF PULMONARY SARCOIDOSIS THORAX, 64, A53 - A53. 10.1136/thx.2009.127084y.
  48. McNulty K,Aguilar S,Scotton CJ,Bonnet D,Janes SM (2009) MURINE HAEMATOPOEITIC STEM CELLS BUT NOT MURINE MESENCHYMAL STEM CELLS AMELIORATE LUNG FIBROSIS USING GENE DELIVERY OF KERATINOCYTE GROWTH FACTOR THORAX, 64, A37 - A38. 10.1136/thx.2009.127076p.
  49. Loebinger MR,Kyrtatos PG,Turmaine M,Price AN,Pankhurst Q,Lythgoe MF,Janes SM (2009) Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles. Cancer Res, 69(23), 8862 - 8867. 10.1158/0008-5472.CAN-09-1912.
  50. Janes SM,Ofstad TA,Campbell DH,Eddaoudi A,Warnes G,Davies D,Watt FM (2009) PI3-kinase-dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation. Cell Res, 19(3), 328 - 339. 10.1038/cr.2008.281.

Biography

Medical Training
I trained in medicine at Charing Cross and Westminster Medical School and completed my MBBS and BSc degrees.  I went on to train as a respiratory physician in the North West Thames region of London working in five of London's hospitals including Harfield transplant centre, Hammersmith and St Mary's Hospital.  I completed an MSc (Distinction) at the Royal Brompton.

Research Training
While at Hammersmith, I became progressively more interested in cancer biology and then joined Fiona Watt's laboratory as an MRC Training Fellow at the then Imperial Cancer Research Fund labs at Lincoln's Inn Fields - now CRUK London Research Institute.  Here I completed a PhD on the role of integrin cell adhesion molecules and their control of apoptosis and differentiation.  I went on to perform an 18 month CRUK post-doctoral period with Fiona and then won an MRC Clinician Scientist Fellowship to start my own group with Geoff Laurent's Centre for Respiratory Research.  My Laboratory focus became the role of stem cells in lung disease pathogenesis and treatments.

Current Research

In 2011, I won my Wellcome Senior Fellowship in Clinical Sciences that underpins my laboratory.  Other funders of my work include the MRC, ESPRC, NIHR, Rosetrees Trust, Roy Castle Lung Foundation and Johnson and Johnson.  In 2012, I formed the Lungs for Living patient information and fund raising group based within UCLH Charitable Foundation and launched the Lungs for Living Research Centre focussing on researching early lung cancer and the role of stem cells in its formation and treatments.

I work as a Consultant in Respiratory Medicine with and interest in Lung Cancer and interventional bronchoscopy.  I run a number of clinical trials focussed on improving diagnostic techniques in lung cancer and other respiratory disorders.  My aim is to improve the patient pathways to treatment.  I am Director of Lung Cancer for North Central and North East London (London Cancer) with the remit to diagnose lung cancer earlier, improve survival and patient experience.


Qualifications

  • 2004: Doctor of Philosophy, University College London
  • 1999: Master of Science, Imperial College of Science, Technology and Medicine
  • 1995: Member of the Royal College of Physicians, Royal College of Physicians
  • 1991: Bachelor of Medicine/Bachelor of Surgery, University of London
  • 1989: Bachelor of Science (Honours), Imperial College of Science, Technology and Medicine

Keywords

  • ABC transporter
  • Airway remodelling
  • Breast cancer
  • Cancer
  • Cancer progression
  • Cell adhesion
  • Differentiation
  • Fibrosis
  • Gene therapy
  • Idiopathic pulmonary fibrosis
  • Imaging
  • Lung Cancer
  • Lung Cancer Staging
  • Lung disease
  • Nanotechnology
  • Preinvasive
  • Pulmonary fibrosis
  • Regeneration
  • Stem Cells
  • Stem cells