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Prof Philippa Talmud

Summary

I graduated from University of Cape Town in Physiology and Microbiology, but was captivated by genetics. As a result I came to UCL to study for a PhD in Microbial Genetics working under Prof Dan Lewis FRS, in the Dept of


Microbiology. I obtained  my PhD in 1972 and continued working in the field for 9 years. This was a time when molecular genetics was developing and I decided to take a sideways step to work in human genetics, with an interest in understanding human disease. I joined Professor Steve Humphries' lab in 1985 and have been in the field of Cardiovascular Genetics since then. Over that period I feel I have made a valuable contribution to the study of heart disease as a multifactorial/ polygenic disorder. My focus has been the study of genes involved in lipid metabolism. In 2000 I obtained both a DSc from London University and became in MRCPath. In 2004 I was promoted to Professor of Cardiovascular Genetics. I am on the editorial board of several journals and have been a member of the executive committee of the British Atherosclerosis Society, The European lipoprotein Club and the International Society for Nutrigenetics and Nurtigenomics. I currently teach on several BSc and MSc courses at UCL. I am course organiser of the new MSc in Cardiovascular Science  run through the Institute of Cardiovascular Science which will start in October 2012.

Research Summary

I head the Lipid Subgroup within the Centre for Cardiovascular Genetics, in the newly formed Institute of Cardiovascular Science. The focus of the work has been the study of genes involved in lipid metabolism and their contribution to heart disease risk. Initial studies were carried out to compare the effect of genetic variation at the apoE, apoB, AI-CIII-AIV-AV and lipoprotein lipase loci on variation in lipid levels in the general population, focusing on interaction with environmental modulators. More recently the studies have diversified to test, both in vivo and in vitro, the molecular mechanisms of specific mutations identified in these and other candidate genes using prokaryotic and tissue culture expression systems. We are now testing the efficacy of using genetic information for CHD calibration, precision and risk prediction. We are part of UCLEB, a consortium formed including researchers from  UCL/Edinburgh and Bristol to bring together the large prospective studies that together number >30,000 individuals followed for 10-30 years. These studies are richly phenotyped and we have used both the 50K Cardiochip and 200K Metabochip to genotype these studies. We are using a gene score approach to examine the association with Cardiovascular risk factors and events.
I also have an interest in Gene Ontology and have a small group working with me annotating genes involved in Cardiovascular Processes, funded by the British Heart Foundation.

Research Activities

  • Cardiovascular Genetics
  • Epidemiology of cardiovascular disease
  • cardiovascular epidemiology

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Blake JA,Dolan M,Drabkin H,Hill DP,Ni L,Sitnikov D,Bridges S,Burgess S,Buza T,McCarthy F,Peddinti D,Pillai L,Carbon S,Dietze H,Ireland A,Lewis SE,Mungall CJ,Gaudet P,Chisholm RL,Fey P,Kibbe WA,Basu S,Siegele DA,McIntosh BK,Renfro DP,Zweifel AE,Hu JC,Brown NH,Tweedie S,Alam-Faruque Y,Apweiler R,Auchinchloss A,Axelsen K,Bely B,Blatter M-C,Bonilla C,Bougueleret L,Boutet E,Breuza L,Bridge A,Chan WM,Chavali G,Coudert E,Dimmer E,Estreicher A,Famiglietti L,Feuermann M,Gos A,Gruaz-Gumowski N,Hieta R,Hinz U,Hulo C,Huntley R,James J,Jungo F,Keller G,Laiho K,Legge D,Lemercier P,Lieberherr D,Magrane M,Martin MJ,Masson P,Mutowo-Muellenet P,O'Donovan C,Pedruzzi I,Pichler K,Poggioli D,Millan PP,Poux S,Rivoire C,Roechert B,Sawford T,Schneider M,Stutz A,Sundaram S,Tognolli M,Xenarios I,Foulger R,Lomax J,Roncaglia P,Khodiyar VK,Lovering RC,Talmud PJ,Chibucos M,Giglio MG,Chang H-Y,Hunter S,McAnulla C,Mitchell A,Sangrador A,Stephan R,Harris MA,Oliver SG,Rutherford K,Wood V,Bahler J,Lock A,Kersey PJ,McDowall MD,Staines DM,Dwinell M,Shimoyama M,Laulederkind S,Hayman T,Wang S-J,Petri V,Lowry T,D'Eustachio P,Matthews L,Balakrishnan R,Binkley G,Cherry JM,Costanzo MC,Dwight SS,Engel SR,Fisk DG,Hitz BC,Hong EL,Karra K,Miyasato SR,Nash RS,Park J,Skrzypek MS,Weng S,Wong ED,Berardini TZ,Li D,Huala E,Mi H,Thomas PD,Chan J,Kishore R,Sternberg P,Van Auken K,Howe D,Westerfield M,Consortium GO (2013) Gene Ontology Annotations and Resources NUCLEIC ACIDS RESEARCH, 41(D1), D530 - D535. 10.1093/nar/gks1050.
  2. Talmud PJ,Shah S,Whittall R,Futema M,Howard P,Cooper JA,Harrison SC,Li K,Drenos F,Karpe F,Neil HA,Descamps OS,Langenberg C,Lench N,Kivimaki M,Whittaker J,Hingorani AD,Kumari M,Humphries SE (2013) Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study. Lancet, 381(9874), 1293 - 1301. 10.1016/S0140-6736(12)62127-8.
  3. Shah T,Zabaneh D,Gaunt T,Swerdlow DI,Shah S,Talmud PJ,Day IN,Whittaker J,Holmes MV,Sofat R,Humphries SE,Kivimaki M,Kumari M,Hingorani AD,Casas JP (2013) Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. Circ Cardiovasc Genet, 6(2), 163 - 170. 10.1161/CIRCGENETICS.112.964254.
  4. Shah S,Casas JP,Drenos F,Whittaker J,Deanfield J,Swerdlow DI,Holmes MV,Kivimaki M,Langenberg C,Wareham N,Gertow K,Sennblad B,Strawbridge RJ,Baldassarre D,Veglia F,Tremoli E,Gigante B,de Faire U,Kumari M,Talmud PJ,Hamsten A,Humphries SE,Hingorani AD (2013) Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis. Circ Cardiovasc Genet, 6(1), 63 - 72. 10.1161/CIRCGENETICS.112.963140.
  5. Khan TA,Shah T,Prieto D,Zhang W,Price J,Fowkes GR,Cooper J,Talmud PJ,Humphries SE,Sundstrom J,Hubacek JA,Ebrahim S,Lawlor DA,Ben-Shlomo Y,Abdollahi MR,Slooter AJ,Szolnoki Z,Sandhu M,Wareham N,Frikke-Schmidt R,Tybjærg-Hansen A,Fillenbaum G,Heijmans BT,Katsuya T,Gromadzka G,Singleton A,Ferrucci L,Hardy J,Worrall B,Rich SS,Matarin M,Whittaker J,Gaunt TR,Whincup P,Morris R,Deanfield J,Donald A,Davey Smith G,Kivimaki M,Kumari M,Smeeth L,Khaw KT,Nalls M,Meschia J,Sun K,Hui R,Day I,Hingorani AD,Casas JP (2013) Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals. Int J Epidemiol, 42(2), 475 - 492. 10.1093/ije/dyt034.
  6. Shah S,Casas JP,Gaunt TR,Cooper J,Drenos F,Zabaneh D,Swerdlow DI,Shah T,Sofat R,Palmen J,Kumari M,Kivimaki M,Ebrahim S,Smith GD,Lawlor DA,Talmud PJ,Whittaker J,Day IN,Hingorani AD,Humphries SE (2013) Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies. Eur Heart J, 34(13), 972 - 981. 10.1093/eurheartj/ehs243.
  7. Hu Y,Li L,Ehm MG,Bing N,Song K,Nelson MR,Talmud PJ,Hingorani AD,Kumari M,Kivimäki M,Xu CF,Waterworth DM,Whittaker JC,Abecasis GR,Spino C,Kang HM (2013) The benefits of using genetic information to design prevention trials. Am J Hum Genet, 92(4), 547 - 557. 10.1016/j.ajhg.2013.03.003.
  8. Codd V,Nelson CP,Albrecht E,Mangino M,Deelen J,Buxton JL,Hottenga JJ,Fischer K,Esko T,Surakka I,Broer L,Nyholt DR,Mateo Leach I,Salo P,Hägg S,Matthews MK,Palmen J,Norata GD,O'Reilly PF,Saleheen D,Amin N,Balmforth AJ,Beekman M,de Boer RA,Böhringer S,Braund PS,Burton PR,Craen AJ,Denniff M,Dong Y,Douroudis K,Dubinina E,Eriksson JG,Garlaschelli K,Guo D,Hartikainen AL,Henders AK,Houwing-Duistermaat JJ,Kananen L,Karssen LC,Kettunen J,Klopp N,Lagou V,van Leeuwen EM,Madden PA,Mägi R,Magnusson PK,Männistö S,McCarthy MI,Medland SE,Mihailov E,Montgomery GW,Oostra BA,Palotie A,Peters A,Pollard H,Pouta A,Prokopenko I,Ripatti S,Salomaa V,Suchiman HE,Valdes AM,Verweij N,Viñuela A,Wang X,Wichmann HE,Widen E,Willemsen G,Wright MJ,Xia K,Xiao X,van Veldhuisen DJ,Catapano AL,Tobin MD,Hall AS,Blakemore AI,van Gilst WH,Zhu H,Consortium C,Erdmann J,Reilly MP,Kathiresan S,Schunkert H,Talmud PJ,Pedersen NL,Perola M,Ouwehand W,Kaprio J,Martin NG,van Duijn CM,Hovatta I,Gieger C,Metspalu A,Boomsma DI,Jarvelin MR,Slagboom PE,Thompson JR,Spector TD,van der Harst P,Samani NJ (2013) Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet, 45(4), 422 - 427e2. 10.1038/ng.2528.
  9. Kalea AZ,Harrison SC,Stephens JW,Talmud PJ (2012) Genetic susceptibility for coronary heart disease and type 2 diabetes complications. Clin Chem, 58(5), 818 - 820. 10.1373/clinchem.2012.182725.
  10. Blake JA,Dolan M,Drabkin H,Hill DP,Ni L,Sitnikov D,Burgess S,Buza T,Gresham C,McCarthy F,Pillai L,Wang H,Carbon S,Lewis SE,Mungall CJ,Gaudet P,Chisholm RL,Fey P,Kibbe WA,Basu S,Siegele DA,McIntosh BK,Renfro DP,Zweifel AE,Hu JC,Brown NH,Tweedie S,Alam-Faruque Y,Apweiler R,Auchinchloss A,Axelsen K,Argoud-Puy G,Bely B,Blatter M-C,Bougueleret L,Boutet E,Branconi-Quintaje S,Breuza L,Bridge A,Browne P,Chan WM,Coudert E,Cusin I,Dimmer E,Duek-Roggli P,Eberhardt R,Estreicher A,Famiglietti L,Ferro-Rojas S,Feuermann M,Gardner M,Gos A,Gruaz-Gumowski N,Hinz U,Hulo C,Huntley R,James J,Jimenez S,Jungo F,Keller G,Laiho K,Legge D,Lemercier P,Lieberherr D,Magrane M,Martin MJ,Masson P,Moinat M,O'Donovan C,Pedruzzi I,Pichler K,Poggioli D,Millan PP,Poux S,Rivoire C,Roechert B,Sawford T,Schneider M,Sehra H,Stanley E,Stutz A,Sundaram S,Tognolli M,Xenarios I,Foulger R,Lomax J,Roncaglia P,Camon E,Khodiyar VK,Lovering RC,Talmud PJ,Chibucos M,Giglio MG,Dolinski K,Heinicke S,Livstone MS,Stephan R,Harris MA,Oliver SG,Rutherford K,Wood V,Bahler J,Lock A,Kersey PJ,McDowall MD,Staines DM,Dwinell M,Shimoyama M,Laulederkind S,Hayman T,Wang S-J,Petri V,Lowry T,D'Eustachio P,Matthews L,Amundsen CD,Balakrishnan R,Binkley G,Cherry JM,Christie KR,Costanzo MC,Dwight SS,Engel SR,Fisk DG,Hirschman JE,Hitz BC,Hong EL,Karra K,Krieger CJ,Miyasato SR,Nash RS,Park J,Skrzypek MS,Weng S,Wong ED,Berardini TZ,Li D,Huala E,Slonim D,Wick H,Thomas P,Chan J,Kishore R,Sternberg P,Van Auken K,Howe D,Westerfield M,Consortium GO (2012) The Gene Ontology: enhancements for 2011 NUCLEIC ACIDS RESEARCH, 40(D1), D559 - D564. 10.1093/nar/gkr1028.
  11. Harrison SC,Cooper JA,Li K,Talmud PJ,Sofat R,Stephens JW,Hamsten A,HIFMECH Consortium ,Sanders J,Montgomery H,Neil A,Simon Broome Research Consortium ,Humphries SE (2012) Association of a sequence variant in DAB2IP with coronary heart disease. Eur Heart J, 33(7), 881 - 888. 10.1093/eurheartj/ehr075.
  12. Talmud PJ (2012) Commentary on the paper by Gustavsson et al. entitled 'Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women'. Atherosclerosis, 220(2), 323 - 324. 10.1016/j.atherosclerosis.2011.10.024.
  13. Yiannakouris N,Cooper JA,Shah S,Drenos F,Ireland HA,Stephens JW,Li KW,Elkeles R,Godsland IF,Kivimaki M,Hingorani AD,Kumari M,Talmud PJ,Humphries SE (2012) IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk. Nutr Metab Cardiovasc Dis, 22(12), 1024 - 1030. 10.1016/j.numecd.2011.05.009.
  14. Angelakopoulou A,Shah T,Sofat R,Shah S,Berry DJ,Cooper J,Palmen J,Tzoulaki I,Wong A,Jefferis BJ,Maniatis N,Drenos F,Gigante B,Hardy R,Laxton RC,Leander K,Motterle A,Simpson IA,Smeeth L,Thomson A,Verzilli C,Kuh D,Ireland H,Deanfield J,Caulfield M,Wallace C,Samani N,Munroe PB,Lathrop M,Fowkes FG,Marmot M,Whincup PH,Whittaker JC,de Faire U,Kivimaki M,Kumari M,Hypponen E,Power C,Humphries SE,Talmud PJ,Price J,Morris RW,Ye S,Casas JP,Hingorani AD (2012) Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Eur Heart J, 33(3), 393 - 407. 10.1093/eurheartj/ehr225.
  15. Gaunt TR,Shah S,Nelson CP,Drenos F,Braund PS,Adeniran I,Folkersen L,Lawlor DA,Casas JP,Amuzu A,Kivimaki M,Whittaker J,Eriksson P,Zhang H,Hancox JC,Tomaszewski M,Burton PR,Tobin MD,Humphries SE,Talmud PJ,Macfarlane PW,Hingorani AD,Samani NJ,Kumari M,Day IN (2012) Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip. Circ Cardiovasc Genet, 5(6), 630 - 638. 10.1161/CIRCGENETICS.112.962852.
  16. Harrison SC,Zabaneh D,Asselbergs FW,Drenos F,Jones GT,Shah S,Gertow K,Sennblad B,Strawbridge RJ,Gigante B,Holewijn S,De Graaf J,Vermeulen S,Folkersen L,van Rij AM,Baldassarre D,Veglia F,Talmud PJ,Deanfield JE,Agu O,Kivimaki M,Kumari M,Bown MJ,Nyyssönen K,Rauramaa R,Smit AJ,Franco-Cereceda A,Giral P,Mannarino E,Silveira A,Syvänen A-C,de Borst GJ,van der Graaf Y,de Faire U,Baas AF,Blankensteijn JD,Wareham NJ,Fowkes G,Tzoulaki I,Price JF,Tremoli E,Hingorani AD,Eriksson P,Hamsten A,Humphries SE (2012) A gene-centric study of common carotid artery remodelling Atherosclerosis.
  17. Pillay N,Plagnol V,Tarpey PS,Lobo SB,Presneau N,Szuhai K,Halai D,Berisha F,Cannon SR,Mead S,Kasperaviciute D,Palmen J,Talmud PJ,Kindblom LG,Amary MF,Tirabosco R,Flanagan AM (2012) A common single-nucleotide variant in T is strongly associated with chordoma. Nat Genet, 44(11), 1185 - 1187. 10.1038/ng.2419.
  18. Costelloe SJ,El-Sayed Moustafa JS,Drenos F,Palmen J,Li Q,Whiting S,Thomas M,Kivimaki M,Kumari M,Hingorani AD,Tzoulaki I,Järvelin MR,Ruokonen A,Hartikainen AL,Pouta A,Walters RG,Blakemore AI,Humphries SE,Coin LJ,Talmud PJ (2012) Gene-targeted analysis of copy number variants identifies 3 novel associations with coronary heart disease traits. Circ Cardiovasc Genet, 5(5), 555 - 560. 10.1161/CIRCGENETICS.111.961037.
  19. Saxena R,Elbers CC,Guo Y,Peter I,Gaunt TR,Mega JL,Lanktree MB,Tare A,Castillo BA,Li YR,Johnson T,Bruinenberg M,Gilbert-Diamond D,Rajagopalan R,Voight BF,Balasubramanyam A,Barnard J,Bauer F,Baumert J,Bhangale T,Böhm BO,Braund PS,Burton PR,Chandrupatla HR,Clarke R,Cooper-DeHoff RM,Crook ED,Davey-Smith G,Day IN,de Boer A,de Groot MC,Drenos F,Ferguson J,Fox CS,Furlong CE,Gibson Q,Gieger C,Gilhuijs-Pederson LA,Glessner JT,Goel A,Gong Y,Grant SF,Grobbee DE,Hastie C,Humphries SE,Kim CE,Kivimaki M,Kleber M,Meisinger C,Kumari M,Langaee TY,Lawlor DA,Li M,Lobmeyer MT,Maitland-van der Zee AH,Meijs MF,Molony CM,Morrow DA,Murugesan G,Musani SK,Nelson CP,Newhouse SJ,O'Connell JR,Padmanabhan S,Palmen J,Patel SR,Pepine CJ,Pettinger M,Price TS,Rafelt S,Ranchalis J,Rasheed A,Rosenthal E,Ruczinski I,Shah S,Shen H,Silbernagel G,Smith EN,Spijkerman AW,Stanton A,Steffes MW,Thorand B,Trip M,van der Harst P,van der A DL,van Iperen EP,van Setten J,van Vliet-Ostaptchouk JV,Verweij N,Wolffenbuttel BH,Young T,Zafarmand MH,Zmuda JM,Look AHEAD Research Group ,DIAGRAM consortium ,Boehnke M,Altshuler D,McCarthy M,Kao WH,Pankow JS,Cappola TP,Sever P,Poulter N,Caulfield M,Dominiczak A,Shields DC,Bhatt DL,Zhang L,Curtis SP,Danesh J,Casas JP,van der Schouw YT,Onland-Moret NC,Doevendans PA,Dorn GW,Farrall M,FitzGerald GA,Hamsten A,Hegele R,Hingorani AD,Hofker MH,Huggins GS,Illig T,Jarvik GP,Johnson JA,Klungel OH,Knowler WC,Koenig W,März W,Meigs JB,Melander O,Munroe PB,Mitchell BD,Bielinski SJ,Rader DJ,Reilly MP,Rich SS,Rotter JI,Saleheen D,Samani NJ,Schadt EE,Shuldiner AR,Silverstein R,Kottke-Marchant K,Talmud PJ,Watkins H,Asselbergs FW,de Bakker PI,McCaffery J,Wijmenga C,Sabatine MS,Wilson JG,Reiner A,Bowden DW,Hakonarson H,Siscovick DS,Keating BJ (2012) Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet, 90(3), 410 - 425. 10.1016/j.ajhg.2011.12.022.
  20. Papp AC,Pinsonneault JK,Wang D,Newman LC,Gong Y,Johnson JA,Pepine CJ,Kumari M,Hingorani AD,Talmud PJ,Shah S,Humphries SE,Sadee W (2012) Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk. PLoS One, 7(3), e31930. 10.1371/journal.pone.0031930.
  21. Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium ,Hingorani AD,Casas JP (2012) The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet, 379(9822), 1214 - 1224. 10.1016/S0140-6736(12)60110-X.
  22. Exeter HJ,Folkersen L,Palmen J,Franco-Cereceda A,Cooper JA,Kalea AZ,Hooft FV,Eriksson P,Humphries SE,Talmud PJ (2012) Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels. PLoS One, 7(7), e41139. 10.1371/journal.pone.0041139.
  23. Walker AP,Fowkes RC,Saleh F,Kim SH,Wilkinson P,Cabrera-Sharp V,Talmud PJ,Humphries SE,Looijenga LH,Bouloux PM (2012) Genetic analysis of NR0B1 in congenital adrenal hypoplasia patients: identification of a rare regulatory variant resulting in congenital adrenal hypoplasia and hypogonadal hypogonadism without testicular carcinoma in situ. Sex Dev, 6(6), 284 - 291. 10.1159/000342295.
  24. Smith AJP,Howard P,Shah S,Eriksson P,Stender S,Giambartolomei C,Folkersen L,Tybjærg-Hansen A,Kumari M,Palmen J,Hingorani AD,Talmud PJ,Humphries SE (2012) Use of Allele-Specific FAIRE to Determine Functional Regulatory Polymorphism Using Large-Scale Genotyping Arrays PLoS Genetics, 8(8).
  25. Asselbergs F,Guo Y,van Iperen EA,Sivapalaratnam S,Tragante V,Lanktree M,Lange L,Almoguera B,Appelman Y,Barnard J,Baumert J,Beitelshees A,Bhangale T,Chen Y-D,Gaunt T,Gong Y,Hopewell J,Johnson T,Kleber M,Langaee T,Li M,Li Y,Liu K,McDonough C,Meijs ML,Middelberg RS,Musunuru K,Nelson C,O'Connell J,Padmanabhan S,Pankow J,Pankratz N,Rafelt S,Rajagopalan R,Romaine SR,Schork N,Shaffer J,Shen H,Smith E,Tischfield S,van der Most P,van Vliet-Ostaptchouk J,Verweij N,Volcik K,Zhang L,Bailey K,Bailey K,Bauer F,Boer JA,Braund P,Burt A,Burton P,Buxbaum S,Chen W,Cooper-DeHoff R,Cupples L,deJong J,Delles C,Duggan D,Fornage M,Furlong C,Glazer N,Gums J,Hastie C,Holmes M,Illig T,Kirkland S,Kivimaki M,Klein R,Klein B,Kooperberg C,Kottke-Marchant K,Kumari M,LaCroix A,Mallela L,Murugesan G,Ordovas J,Ouwehand W,Post W,Saxena R,Scharnagl H,Schreiner P,Shah T,Shields D,Shimbo D,Srinivasan S,Stolk R,Swerdlow D,Taylor Jr H,Topol E,Toskala E,van Pelt J,van Setten J,Yusuf S,Whittaker J,Zwinderman AH,Anand S,Balmforth A,Berenson G,Bezzina C,Boehm B,Boerwinkle E,Casas J,Caulfield M,Clarke R,Connell J,Cruickshanks K,Davidson K,Day IM,de Bakker PW,Doevendans P,Dominiczak A,Hall A,Hartman C,Hengstenberg C,Hillege H,Hofker M,Humphries S,Jarvik G,Johnson J,Kaess B,Kathiresan S,Koenig W,Lawlor D,März W,Melander O,Mitchell B,Montgomery G,Munroe P,Murray S,Newhouse S,Onland-Moret N,Poulter N,Psaty B,Redline S,Rich S,Rotter J,Schunkert H,Sever P,Shuldiner A,Silverstein R,Stanton A,Thorand B,Trip M,Tsai M,van der Harst P,van der Schoot E,van der Schouw Y,Verschuren WM,Watkins H,Wilde AM,Wolffenbuttel BR,Whitfield J,Hovingh G,Ballantyne C,Wijmenga C,Reilly M,Martin N,Wilson J,Rader D,Samani N,Reiner A,Hegele R,Kastelein JP,Hingorani A,Talmud P,Hakonarson H,Elbers C,Keating B,Drenos F (2012) Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci American Journal of Human Genetics.
  26. Johnson T,Gaunt TR,Newhouse SJ,Padmanabhan S,Tomaszewski M,Kumari M,Morris RW,Tzoulaki I,O'Brien ET,Poulter NR,Sever P,Shields DC,Thom S,Wannamethee SG,Whincup PH,Brown MJ,Connell JM,Dobson RJ,Howard PJ,Mein CA,Onipinla A,Shaw-Hawkins S,Zhang Y,Davey Smith G,Day IN,Lawlor DA,Goodall AH,Cardiogenics Consortium ,Fowkes FG,Abecasis GR,Elliott P,Gateva V,Global BPgen Consortium ,Braund PS,Burton PR,Nelson CP,Tobin MD,van der Harst P,Glorioso N,Neuvrith H,Salvi E,Staessen JA,Stucchi A,Devos N,Jeunemaitre X,Plouin PF,Tichet J,Juhanson P,Org E,Putku M,Sõber S,Veldre G,Viigimaa M,Levinsson A,Rosengren A,Thelle DS,Hastie CE,Hedner T,Lee WK,Melander O,Wahlstrand B,Hardy R,Wong A,Cooper JA,Palmen J,Chen L,Stewart AF,Wells GA,Westra HJ,Wolfs MG,Clarke R,Franzosi MG,Goel A,Hamsten A,Lathrop M,Peden JF,Seedorf U,Watkins H,Ouwehand WH,Sambrook J,Stephens J,Casas JP,Drenos F,Holmes MV,Kivimaki M,Shah S,Shah T,Talmud PJ,Whittaker J,Wallace C,Delles C,Laan M,Kuh D,Humphries SE,Nyberg F,Cusi D,Roberts R,Newton-Cheh C,Franke L,Stanton AV,Dominiczak AF,Farrall M,Hingorani AD,Samani NJ,Caulfield MJ,Munroe PB (2011) Blood pressure loci identified with a gene-centric array. Am J Hum Genet, 89(6), 688 - 700. 10.1016/j.ajhg.2011.10.013.
  27. Smart-Halajko MC,Kelley-Hedgepeth A,Montefusco MC,Cooper JA,Kopin A,McCaffrey JM,Balasubramanyam A,Pownall HJ,Nathan DM,Peter I,Talmud PJ,Huggins GS,Look AHEAD Study (2011) ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial. BMC Med Genet, 12, 89. 10.1186/1471-2350-12-89.
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Biography

I graduated from University of Cape Town in Physiology and Microbiology, but was captivated by genetics. As a result I came to UCL to study for a PhD in Microbial Genetics working under Prof Dan Lewis FRS, in the Dept of


Microbiology. I obtained  my PhD in 1972 and continued working in the field for 9 years. This was a time when molecular genetics was developing and I decided to take a sideways step to work in human genetics, with an interest in understanding human disease. I joined Professor Steve Humphries' lab in 1985 and have been in the field of Cardiovascular Genetics since then. Over that period I feel I have made a valuable contribution to the study of heart disease as a multifactorial/ polygenic disorder. My focus has been the study of genes involved in lipid metabolism. In 2000 I obtained both a DSc from London University and became in MRCPath. In 2004 I was promoted to Professor of Cardiovascular Genetics. I am on the editorial board of several journals and have been a member of the executive committee of the British Atherosclerosis Society, The European lipoprotein Club and the International Society for Nutrigenetics and Nurtigenomics. I currently teach on several BSc and MSc courses at UCL. I am course organiser of the new MSc in Cardiovascular Science  run through the Institute of Cardiovascular Science which will start in October 2012.

Keywords

  • Angiogenesis
  • Atherosclerosis
  • Bioinformatic analysis
  • Bioinformatics
  • Cardiovascular
  • Epigenetics
  • Gene Ontology
  • Gene expression
  • Genetic screens
  • Genetically encoded reporters/indicators
  • Genetics
  • Genomewide association analysis
  • Genomic analyses
  • Genomics
  • In vitro models
  • In vivo models
  • Lipid
  • Lipoproteins
  • Longitudinal analysis
  • Mendelian randomisation
  • Molecular epidemiology