PHP Code

Using the PHP code extracts allows Academic Staff Profiles to be displayed in a number of different styles including the tabbed format shown below - the data is provided dynamically from the IRIS application, while maintaning the consistent look and feel of your site.

Prof Nikolaos Donos

  • Extension:

    020 3456 1075

  • Email:

    n.donos@ucl.ac.uk

  • Webpage:

    http://www.ucl.ac.uk/eastman

  • Address:

    - UCL Eastman Dental Institute,
    256 Gray’s Inn Road,
    London,
    WC1X 8LD

  • Appointments:

    Professor of Peridontology, Restorative Dental Sciences, Eastman Dental Institute
No image is available

Research Summary

I am involved in three major research themes: (i) wound healing, (ii) infection & inflammation and (iii) evidence based oral health. Within these themes the following subjects are integrated: * in vitro and in vivo models related to wound healing and tissue regeneration * the effect of periodontal disease on general health e.g. cardiovascular disease and diabetes * clinical studies on implant dentistry The three themes 1. Wound healing which encompasses translational research in all three levels (in vitro, in vivo/preclinical and clinical trials) in soft and hard tissue regeneration, healing processes following non surgical and surgical procedures in health and in chronic diseases (diabetes, osteoporosis) and implant dentistry. 2. Inflammation & infection, which encompasses the area of periodontal medicine (association of oral health with cardiovascular diseases, diabetes, osteoporosis), genetic susceptibility and association with chronic general health diseases. 3. Outcome based oral health which includes systematic reviews in Periodontology and Implantology as well as innovative methodology in data synthesis. 1. Wound healing: The Clinical research Division has a significant translational research expertise and track record in preclinical and clinical studies on the effect of active biologic peptides such as enamel matrix proteins and bone grafts in periodontal and bone regeneration. Furthermore, ongoing studies are focused on the early and late bone healing in healthy and diabetic or osteoporotic conditions.The Division has a complete programme of translational research from the basic in vitro studies to preclinical and controlled clinical trials where the effect of different implant surfaces or biomaterials is evaluated in terms of molecular, histological and clinical healing. Furthermore, the research team is establishing translational research in stem cells and their possible application in the field of periodontology and implantology.

Research Activities

  • Impact of oral health on general health & wellbeing, evidence-based healthcare and research synthesi
  • diabetes
  • periodontal medicine
  • tissue regeneration
  • wound healing

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Horváth A,Mardas N,Mezzomo LA,Needleman IG,Donos N (2013) Alveolar ridge preservation. A systematic review. Clin Oral Investig, 17(2), 341 - 363. 10.1007/s00784-012-0758-5.
  2. Nibali L,Medlar A,Stanescu H,Kleta R,Darbar U,Donos N (2013) Linkage analysis confirms heterogeneity of hereditary gingival fibromatosis. Oral Dis, 19(1), 100 - 105. 10.1111/j.1601-0825.2012.01965.x.
  3. Lee SB,Retzepi M,Petrie A,Hakimi AR,Schwarz F,Donos N (2013) The effect of diabetes on bone formation following application of the GBR principle with the use of titanium domes. Clin Oral Implants Res, 24(1), 28 - 35. 10.1111/j.1600-0501.2012.02448.x.
  4. Nibali L,Donos N (2013) Periodontitis and redox status: a review. Curr Pharm Des, 19(15), 2687 - 2697.
  5. Patel K,Mardas N,Donos N (2013) Radiographic and clinical outcomes of implants placed in ridge preserved sites: a 12-month post-loading follow-up. Clin Oral Implants Res, 24(6), 599 - 605. 10.1111/j.1600-0501.2012.02500.x.
  6. Nibali L,Pelekos G,D'Aiuto F,Chaudhary N,Habeeb R,Ready D,Parkar M,Donos N (2013) Influence of IL-6 haplotypes on clinical and inflammatory response in aggressive periodontitis. Clin Oral Investig, 17(4), 1235 - 1242. 10.1007/s00784-012-0804-3.
  7. Needleman I,Hyun-Ryu J,Brealey D,Sachdev M,Moskal-Fitzpatrick D,Bercades G,Nagle J,Lewis K,Agudo E,Petrie A,Suvan J,Donos N,Singer M (2012) The impact of hospitalization on dental plaque accumulation: an observational study. J Clin Periodontol, 39(11), 1011 - 1016. 10.1111/j.1600-051X.2012.01939.x.
  8. Khan MR,Donos N,Salih V,Brett PM (2012) The enhanced modulation of key bone matrix components by modified Titanium implant surfaces. Bone, 50(1), 1 - 8. 10.1016/j.bone.2011.07.040.
  9. Dereka X,Mardas N,Chin S,Petrie A,Donos N (2012) A systematic review on the association between genetic predisposition and dental implant biological complications Clinical Oral Implants Research, 23(7), 775 - 788.
  10. Dereka X,Mardas N,Chin S,Petrie A,Donos N (2012) A systematic review on the association between genetic predisposition and dental implant biological complications. Clin Oral Implants Res, 23(7), 775 - 788. 10.1111/j.1600-0501.2011.02329.x.
  11. Amin HD,Olsen I,Knowles JC,Donos N (2012) Differential effect of amelogenin peptides on osteogenic differentiation in vitro: identification of possible new drugs for bone repair and regeneration. Tissue Eng Part A, 18(11-12), 1193 - 1202. 10.1089/ten.TEA.2011.0375.
  12. Amin HD,Olsen I,Knowles JC,Dard M,Donos N (2012) Effects of enamel matrix proteins on multi-lineage differentiation of periodontal ligament cells in vitro.. 10.1016/j.actbio.2012.09.008.
  13. Nibali L,Fedele S,D'Aiuto F,Donos N (2012) Interleukin-6 in oral diseases: A review Oral Diseases, 18(3), 236 - 243.
  14. Nibali L,Fedele S,D'Aiuto F,Donos N (2012) Interleukin-6 in oral diseases: a review. Oral Dis, 18(3), 236 - 243. 10.1111/j.1601-0825.2011.01867.x.
  15. Tomás I,Diz P,Tobías A,Scully C,Donos N (2012) Periodontal health status and bacteraemia from daily oral activities: systematic review/meta-analysis. J Clin Periodontol, 39(3), 213 - 228. 10.1111/j.1600-051X.2011.01784.x.
  16. Donos N (2012) Summary of: Specialists' management decisions and attitudes towards mucositis and peri-implantitis BRITISH DENTAL JOURNAL, 212(1), 30 - 31.
  17. Donos N (2012) Summary of: Specialists' management decisions and attitudes towards mucositis and peri-implantitis. Br Dent J, 212(1), 30 - 31. 10.1038/sj.bdj.2012.26.
  18. Zambon R,Mardas N,Horvath A,Petrie A,Dard M,Donos N (2012) The effect of loading in regenerated bone in dehiscence defects following a combined approach of bone grafting and GBR. Clin Oral Implants Res, 23(5), 591 - 601. 10.1111/j.1600-0501.2011.02279.x.
  19. Furze D,Byrne A,Donos N,Mardas N (2012) Clinical and esthetic outcomes of single-tooth implants in the anterior maxilla. Quintessence Int, 43(2), 127 - 134.
  20. Nibali L,Brett PM,Donos N,Griffiths GS (2012) Hereditary gingival hyperplasia associated with amelogenesis imperfecta: a case report. Quintessence Int, 43(6), 483 - 489.
  21. Donos N,Laurell L,Mardas N (2012) Hierarchical decisions on teeth vs. implants in the periodontitis-susceptible patient: the modern dilemma. Periodontol 2000, 59(1), 89 - 110. 10.1111/j.1600-0757.2011.00433.x.
  22. Nibali L,D'Aiuto F,Ready D,Parkar M,Yahaya R,Donos N (2012) No association between A actinomycetemcomitans or P gingivalis and chronic or aggressive periodontitis diagnosis. Quintessence Int, 43(3), 247 - 254.
  23. Needleman I,Chin S,O'Brien T,Petrie A,Donos N (2012) Systematic review of outcome measurements and reference group(s) to evaluate and compare implant success and failure Journal of Clinical Periodontology, 39(SUPPL.12), 122 - 132.
  24. Khan MR,Donos N,Salih V,Brett PM (2012) The enhanced modulation of key bone matrix components by modified Titanium implant surfaces Bone, 50(1), 1 - 8.
  25. Albrektsson T,Donos N,Working Group 1 (2012) Implant survival and complications. The Third EAO consensus conference 2012. Clin Oral Implants Res, 23 Suppl 6, 63 - 65. 10.1111/j.1600-0501.2012.02557.x.
  26. Amin HD,Olsen I,Knowles J,Donos N (2011) A procedure for identifying stem cell compartments with multi-lineage differentiation potential Analyst, 136(7), 1440 - 1449.
  27. Donos N,Graziani F,Mardas N,Kostopoulos L (2011) The use of human hypertrophic chondrocytes-derived extracellular matrix for the treatment of critical-size calvarial defects. Clin Oral Implants Res, 22(12), 1346 - 1353. 10.1111/j.1600-0501.2010.02120.x.
  28. Suvan J,D'Aiuto F,Moles DR,Petrie A,Donos N (2011) Association between overweight/obesity and periodontitis in adults. A systematic review Obesity Reviews, 12(501), e381 - e404.
  29. Gellynck K,Neel EA,Li H,Mardas N,Donos N,Buxton P,Young AM (2011) Cell attachment and response to photocured, degradable bone adhesives containing tricalcium phosphate and purmorphamine. Acta Biomater, 7(6), 2672 - 2677. 10.1016/j.actbio.2011.02.033.
  30. Fedele S,Sabbah W,Donos N,Porter S,D'Aiuto F (2011) Common oral mucosal diseases, systemic inflammation, and cardiovascular diseases in a large cross-sectional US survey. Am Heart J, 161(2), 344 - 350. 10.1016/j.ahj.2010.11.009.
  31. Lang NP,Salvi GE,Huynh-Ba G,Ivanovski S,Donos N,Bosshardt DD (2011) Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans CLIN ORAL IMPLAN RES, 22(4), 349 - 356. 10.1111/j.1600-0501.2011.02172.x.
  32. Liñares A,Mardas N,Dard M,Donos N (2011) Effect of immediate or delayed loading following immediate placement of implants with a modified surface. Clin Oral Implants Res, 22(1), 38 - 46. 10.1111/j.1600-0501.2010.01988.x.
  33. Donos N,Hamlet S,Lang NP,Salvi GE,Huynh-Ba G,Bosshardt DD,Ivanovski S (2011) Gene expression profile of osseointegration of a hydrophilic compared with a hydrophobic microrough implant surface CLIN ORAL IMPLAN RES, 22(4), 365 - 372. 10.1111/j.1600-0501.2010.02113.x.
  34. Costa Araújo N,De Aguiar Bello DM,Crovella S,De Souza PRE,Donos N,Cimões R (2011) Mannose binding lectin genes (MBL2) polymorpshisms and the periodontal disease in diabetic patients Revista Odonto Ciencia, 26(3), 203 - 208.
  35. Masi S,Salpea KD,Li K,Parkar M,Nibali L,Donos N,Patel K,Taddei S,Deanfield JE,D'Aiuto F,Humphries SE (2011) Oxidative stress, chronic inflammation, and telomere length in patients with periodontitis. Free Radic Biol Med, 50(6), 730 - 735. 10.1016/j.freeradbiomed.2010.12.031.
  36. Bello DMA,Araújo NC,Gusmão ES,de Souza PRE,Donos N,Cimões R (2011) Periodontal conditions and metabolic control markers in diabetic patients | Condição periodontal e marcadores do controle metabólico em pacientes diabéticos Pesquisa Brasileira em Odontopediatria e Clinica Integrada, 11(3), 357 - 361.
  37. Bosshardt DD,Salvi GE,Huynh-Ba G,Ivanovski S,Donos N,Lang NP (2011) The role of bone debris in early healing adjacent to hydrophilic and hydrophobic implant surfaces in man CLIN ORAL IMPLAN RES, 22(4), 357 - 364. 10.1111/j.1600-0501.2010.02107.x.
  38. Ivanovski S,Hamlet S,Salvi GE,Huynh-Ba G,Bosshardt DD,Lang NP,Donos N (2011) Transcriptional profiling of osseointegration in humans CLIN ORAL IMPLAN RES, 22(4), 373 - 381. 10.1111/j.1600-0501.2010.02112.x.
  39. Suvan J,D'Aiuto F,Moles DR,Petrie A,Donos N (2011) Association between overweight/obesity and periodontitis in adults. A systematic review. Obes Rev, 12(5), e381 - e404. 10.1111/j.1467-789X.2010.00808.x.
  40. Nibali L,Pometti D,Tu YK,Donos N (2011) Clinical and radiographic outcomes following non-surgical therapy of periodontal infrabony defects: a retrospective study. J Clin Periodontol, 38(1), 50 - 57. 10.1111/j.1600-051X.2010.01648.x.
  41. Nibali L,Madden I,Franch Chillida F,Heitz-Mayfield L,Brett P,Donos N (2011) IL6 -174 genotype associated with Aggregatibacter actinomycetemcomitans in Indians. Oral Dis, 17(2), 232 - 237. 10.1111/j.1601-0825.2010.01731.x.
  42. Donos N,Retzepi M,Wall I,Hamlet S,Ivanovski S (2011) In vivo gene expression profile of guided bone regeneration associated with a microrough titanium surface CLIN ORAL IMPLAN RES, 22(4), 390 - 398. 10.1111/j.1600-0501.2010.02105.x.
  43. Ivanovski S,Hamlet S,Retzepi M,Wall I,Donos N (2011) Transcriptional profiling of "guided bone regeneration" in a critical-size calvarial defect CLIN ORAL IMPLAN RES, 22(4), 382 - 389. 10.1111/j.1600-0501.2010.02104.x.
  44. Masi S,Salpea KD,Li K,Parkar M,Nibali L,Donos N,Patel K,Taddei S,Deanfield JE,DAiuto F,Humphries SE (2011) Oxidative stress, chronic inflammation, and telomere length in patients with periodontitis Free Radical Biology and Medicine, 50(6), 730 - 735.
  45. Mardas N,D'Aiuto F,Mezzomo L,Arzoumanidi M,Donos N (2011) Radiographic alveolar bone changes following ridge preservation with two different biomaterials CLIN ORAL IMPLAN RES, 22(4), 416 - 423. 10.1111/j.1600-0501.2010.02154.x.
  46. Nibali L,Donos N (2011) Radiographic bone fill of peri-implantitis defects following nonsurgical therapy: report of three cases. Quintessence Int, 42(5), 393 - 397.
  47. Mardas N,Schwarz F,Petrie A,Hakimi AR,Donos N (2011) The effect of SLActive surface in guided bone formation in osteoporotic-like conditions. Clin Oral Implants Res, 22(4), 406 - 415. 10.1111/j.1600-0501.2010.02094.x.
  48. Mezzomo LA,Shinkai RS,Mardas N,Donos N (2011) Alveolar ridge preservation after dental extraction and before implant placement: A literature review Revista Odonto Ciencia, 26(1), 77 - 83.
  49. Mardas N,Chadha V,Donos N (2010) Alveolar ridge preservation with guided bone regeneration and a synthetic bone substitute or a bovine-derived xenograft: a randomized, controlled clinical trial Clinical Oral Implants Research, 21(7), 688 - 698.
  50. Retzepi M,Donos N (2010) The effect of diabetes mellitus on osseous healing. Clin Oral Implants Res, 21(7), 673 - 681. 10.1111/j.1600-0501.2010.01923.x.

Qualifications

  • 1998: Doctor of Philosophy, Aarhus Universitet
  • 1994: Certificate of Completion of Specialist Training, Aarhus Universitet
  • 1994: Master of Science, Aarhus Universitet
  • 1992: Doctor of Dental Surgery, Aristotle University of Thessaloniki