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Prof Mervyn Singer

Research Summary

1) Mechanisms of sepsis-induced multiple organ failure with particular emphasis on the role of mitochondrial dysfunction 2) Mechanisms of septic shock (and other shock states) with emphasis on the roles of nitric oxide, vasopressin, catecholamines and potassium channels 3) Management and diagnosis of infection (including infection control) in critical care 4) Haemodynamics including physiology and pathophysiology pertaining to shock states 5) Monitoring techniques to assess the macro- and microcirculation, and the adequacy of organ perfusion

Research Activities

  • Critical Care Medicine
  • Staphylococci
  • Understaning the cellular players and soluble medi
  • critical care

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Dyson A,Simon F,Seifritz A,Zimmerling O,Matallo J,Calzia E,Radermacher P,Singer M (2013) Erratum to: Bladder tissue oxygen tension monitoring in pigs subjected to a range of cardiorespiratory and pharmacological challenges. Intensive Care Med, 39(4), 797. 10.1007/s00134-013-2821-3.
  2. Umbrello M,Dyson A,Feelisch M,Singer M (2013) The Key Role of Nitric Oxide in Hypoxia: Hypoxic Vasodilation and Energy Supply-Demand Matching. Antioxid Redox Signal. 10.1089/ars.2012.4979.
  3. Recknagel P,Gonnert FA,Halilbasic E,Gajda M,Jbeily N,Lupp A,Rubio I,Claus RA,Kortgen A,Trauner M,Singer M,Bauer M (2013) Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats. Liver Int, 33(2), 283 - 293. 10.1111/liv.12012.
  4. Rudiger A,Dyson A,Felsmann K,Carré JE,Taylor V,Hughes S,Clatworthy I,Protti A,Pellerin D,Lemm J,Claus RA,Bauer M,Singer M (2013) Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis. Clin Sci (Lond), 124(6), 391 - 401. 10.1042/CS20120334.
  5. Arulkumaran N,Annear NM,Singer M (2013) Patients with end-stage renal disease admitted to the intensive care unit: systematic review. Br J Anaesth, 110(1), 13 - 20. 10.1093/bja/aes401.
  6. Shankar-Hari M,Spencer J,Sewell WA,Rowan KM,Singer M (2012) Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective CRITICAL CARE, 16(2). 10.1186/cc10597.
  7. Singer M (2012) Management of fluid balance: a European perspective. Curr Opin Anaesthesiol, 25(1), 96 - 101. 10.1097/ACO.0b013e32834e8150.
  8. Atlas G,Brealey D,Dhar S,Dikta G,Singer M (2012) Additional hemodynamic measurements with an esophageal Doppler monitor: a preliminary report of compliance, force, kinetic energy, and afterload in the clinical setting JOURNAL OF CLINICAL MONITORING AND COMPUTING, 26(6), 473 - 482. 10.1007/s10877-012-9386-5.
  9. Recknagel P,Gonnert FA,Westermann M,Lambeck S,Lupp A,Rudiger A,Dyson A,Carré JE,Kortgen A,Krafft C,Popp J,Sponholz C,Fuhrmann V,Hilger I,Claus RA,Riedemann NC,Wetzker R,Singer M,Trauner M,Bauer M (2012) Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS Med, 9(11), e1001338. 10.1371/journal.pmed.1001338.
  10. Cuesta JM,Singer M (2012) The stress response and critical illness: a review. Crit Care Med, 40(12), 3283 - 3289. 10.1097/CCM.0b013e31826567eb.
  11. Dyson A,Simon F,Seifritz A,Zimmerling O,Matallo J,Calzia E,Radermacher P,Singer M (2012) Bladder tissue oxygen tension monitoring in pigs subjected to a range of cardiorespiratory and pharmacological challenges. Intensive Care Med, 38(11), 1868 - 1876. 10.1007/s00134-012-2712-z.
  12. Needleman I,Hyun-Ryu J,Brealey D,Sachdev M,Moskal-Fitzpatrick D,Bercades G,Nagle J,Lewis K,Agudo E,Petrie A,Suvan J,Donos N,Singer M (2012) The impact of hospitalization on dental plaque accumulation: an observational study. J Clin Periodontol, 39(11), 1011 - 1016. 10.1111/j.1600-051X.2012.01939.x.
  13. Dyson A,Cone S,Singer M,Ackland GL (2012) Microvascular and macrovascular flow are uncoupled in early polymicrobial sepsis. Br J Anaesth, 108(6), 973 - 978. 10.1093/bja/aes093.
  14. Singer M,Rhodes A (2012) Obituary - David Bennett. Crit Care, 16(2), 122. 10.1186/cc11234.
  15. Singer M,Rhodes A (2012) David bennett 1938-2012. Intensive Care Med, 38(5), 910 - 911. 10.1007/s00134-012-2526-z.
  16. O'Brien AJ,Welch CA,Singer M,Harrison DA (2012) Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients. Intensive Care Med, 38(6), 991 - 1000. 10.1007/s00134-012-2523-2.
  17. Chan YL,Orie NN,Dyson A,Taylor V,Stidwill RP,Clapp LH,Singer M (2012) Inhibition of vascular adenosine triphosphate-sensitive potassium channels by sympathetic tone during sepsis Critical Care Medicine, 40(4), 1261 - 1268. 10.1097/CCM.0b013e31823da98d.
  18. Singer M (2012) Oesophageal Doppler monitoring: a not-so-NICE editorial. Anaesthesia, 67(4), 428 - 430. 10.1111/j.1365-2044.2012.07111.x.
  19. Arulkumaran N,Montero RM,Singer M (2012) Management of the dialysis patient in general intensive care. Br J Anaesth, 108(2), 183 - 192. 10.1093/bja/aer461.
  20. Hill NE,Murphy KG,Singer M (2012) Ghrelin, appetite and critical illness. Curr Opin Crit Care, 18(2), 199 - 205. 10.1097/MCC.0b013e3283514b01.
  21. Rudiger A,Singer M (2012) Acute kidney injury LANCET, 380(9857), 1904 - 1904.
  22. Sprung CL,Annane D,Singer M,Moreno R,Keh D,Grp CORTICUSS (2011) Glucocorticoids in sepsis: dissecting facts from fiction CRITICAL CARE, 15(5). 10.1186/cc10428.
  23. Wilson AP,Smyth D,Moore G,Singleton J,Jackson R,Gant V,Jeanes A,Shaw S,James E,Cooper B,Kafatos G,Cookson B,Singer M,Bellingan G (2011) The impact of enhanced cleaning within the intensive care unit on contamination of the near-patient environment with hospital pathogens: a randomized crossover study in critical care units in two hospitals. Crit Care Med, 39(4), 651 - 658. 10.1097/CCM.0b013e318206bc66.
  24. Vincent J-L,Rhodes A,Perel A,Martin GS,Della Rocca G,Vallet B,Pinsky MR,Hofer CK,Teboul J-L,de Boode W-P,Scolletta S,Vieillard-Baron A,De Backer D,Walley KR,Maggiorini M,Singer M (2011) Clinical review: Update on hemodynamic monitoring - a consensus of 16 CRITICAL CARE, 15(4). 10.1186/cc10291.
  25. Corona A,Singer M (2011) An epistemological dilemma: is ertapenem adequate to treat severe infections in critically ill patients? MINERVA ANESTESIOLOGICA, 77(11), 1027 - 1029.
  26. Moreno R,Sprung CL,Annane D,Chevret S,Briegel J,Keh D,Singer M,Weiss YG,Payen D,Cuthbertson BH,Vincent J-L (2011) Time course of organ failure in patients with septic shock treated with hydrocortisone: results of the Corticus study INTENSIVE CARE MEDICINE, 37(11), 1765 - 1772. 10.1007/s00134-011-2334-x.
  27. Polito A,Sonneville R,Guidoux C,Barrett L,Viltart O,Mattot V,Siami S,de la Grandmaison GL,Chretien F,Singer M,Gray F,Annane D,Brouland J-P,Sharshar T (2011) Changes in CRH and ACTH Synthesis during Experimental and Human Septic Shock PLOS ONE, 6(11). 10.1371/journal.pone.0025905.
  28. Fullerton JN,Singer M (2011) Organ Failure in the ICU: Cellular Alterations SEMIN RESP CRIT CARE, 32(5), 581 - 586. 10.1055/s-0031-1287866.
  29. Gonnert FA,Westermann M,Felsmann K,Claus RA,Singer M,Trauner M,Bauer M (2011) Protection against sepsis-associated cholestaiss despite aggravated hepatocellular injury by selective knock-out of phosphoinositide 3-kinase gamma SHOCK, 36, 28 - 28.
  30. Adlakha A,Pavlou M,Walker DA,Copas AJ,Dufty N,Batson S,Edwards SG,Singer M,Miller RF (2011) Survival of HIV-infected patients admitted to the intensive care unit in the era of highly active antiretroviral therapy. Int J STD AIDS, 22(9), 498 - 504. 10.1258/ijsa.2011.010496.
  31. Singer M,Matthay MA (2011) Clinical review: Thinking outside the box--an iconoclastic view of current practice. Crit Care, 15(4), 225. 10.1186/cc10245.
  32. Singer M,Brealey D (2011) Another nail in the hammer's coffin? Crit Care, 15(4), 179. 10.1186/cc10311.
  33. Miller R,Edwards S,Singer M (2011) 12 Intensive care. HIV Med, 12 Suppl 2, 109 - 111. 10.1111/j.1468-1293.2011.00944_13.x.
  34. Dyson A,Bryan NS,Fernandez BO,Garcia-Saura MF,Saijo F,Mongardon N,Rodriguez J,Singer M,Feelisch M (2011) An integrated approach to assessing nitroso-redox balance in systemic inflammation. Free Radic Biol Med, 51(6), 1137 - 1145. 10.1016/j.freeradbiomed.2011.06.012.
  35. Dyson A,Rudiger A,Singer M (2011) Temporal changes in tissue cardiorespiratory function during faecal peritonitis. Intensive Care Med, 37(7), 1192 - 1200. 10.1007/s00134-011-2227-z.
  36. Prowle JR,Heenen S,Singer M (2011) Infection in the critically ill--questions we should be asking. J Antimicrob Chemother, 66 Suppl 2, ii3 - i10. 10.1093/jac/dkq517.
  37. Cochemé HM,Quin C,McQuaker SJ,Cabreiro F,Logan A,Prime TA,Abakumova I,Patel JV,Fearnley IM,James AM,Porteous CM,Smith RA,Saeed S,Carré JE,Singer M,Gems D,Hartley RC,Partridge L,Murphy MP (2011) Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab, 13(3), 340 - 350. 10.1016/j.cmet.2011.02.003.
  38. Dyson A,Singer M (2011) Tissue oxygen tension monitoring: will it fill the void? Curr Opin Crit Care, 17(3), 281 - 289. 10.1097/MCC.0b013e328344f1dc.
  39. Dyson A,Bezemer R,Legrand M,Balestra G,Singer M,Ince C (2011) Microvascular and interstitial oxygen tension in the renal cortex and medulla studied in a 4-h rat model of LPS-induced endotoxemia. Shock, 36(1), 83 - 89. 10.1097/SHK.0b013e3182169d5a.
  40. O'Brien AJ,Terala D,Orie NN,Davies NA,Zolfaghari P,Singer M,Clapp LH (2011) BK large conductance Ca²+-activated K+ channel-deficient mice are not resistant to hypotension and display reduced survival benefit following polymicrobial sepsis. Shock, 35(5), 485 - 491. 10.1097/SHK.0b013e31820860f5.
  41. Singer M,Jones AM (2011) Bench-to-bedside review: the role of C1-esterase inhibitor in sepsis and other critical illnesses. Crit Care, 15(1), 203. 10.1186/cc9304.
  42. Brealey DA,Singer M,Terblanche M (2011) Potential metabolic consequences of statins in sepsis. Crit Care Med, 39(6), 1514 - 1520. 10.1097/CCM.0b013e31820eb74f.
  43. Singer M (2011) Oesophageal Doppler monitoring: should it be routine for high-risk surgical patients? Curr Opin Anaesthesiol, 24(2), 171 - 176. 10.1097/ACO.0b013e32834452b2.
  44. Townsend W,Holroyd A,Pearce RM,Mackinnon S,Goldstone AH,Linch DC,Peggs KS,Thomson K,Singer M,Naik P,Howell D,Morris E (2011) A Simple Prognostic Score to Predict Short and Long-Term Survival Following ICU Admission in Critically III Adult Allogeneic Hematopoietic Stem Cell Transplant Recipients: Improved Survival Following Reduced Intensity Conditioning BLOOD, 118(21), 70 - 71.
  45. Adlakha AG,Pavlou M,Walker D,Copas AJ,Batson S,Edwards SG,Singer M,Miller RF (2010) SURVIVAL OF HIV-INFECTED PATIENTS ADMITTED TO THE INTENSIVE CARE UNIT THORAX, 65, A38 - A39. 10.1136/thx.2010.150938.33.
  46. Ackland GL,Del Arroyo AG,Yao ST,Stephens RC,Dyson A,Klein NJ,Singer M,Gourine AV (2010) Low molecular weight polyethylene glycol improves survival in experimental sepsis. Critical Care Medicine, 38, 629 - 636.
  47. Singer M,Matthay MA (2010) Thinking outside the box: Introduction. Crit Care Med, 38(10 Suppl), S511. 10.1097/CCM.0b013e3181f3250f.
  48. Vincent JL,Singer M,Marini JJ,Moreno R,Levy M,Matthay MA,Pinsky M,Rhodes A,Ferguson ND,Evans T,Annane D,Hall JB (2010) Thirty years of critical care medicine CRIT CARE, 14(3). 10.1186/cc8979.
  49. Vincent JL,Singer M (2010) Critical Care 3 Critical care: advances and future perspectives LANCET, 376(9749), 1354 - 1361. 10.1016/S0140-6736(10)60575-2.
  50. del Arroyo AG,Singer M,Ackland GL (2010) NEURO-IMMUNOMODULATION OF HUMAN CD14+CD16+NEUTROPHILS IN SEPSIS INTENSIVE CARE MEDICINE, 36, S409 - S409.

Qualifications

  • : Bachelor of Medicine/Bachelor of Surgery, University of London
  • : Member of the Royal College of Physicians, Royal College of Physicians

Keywords

  • Cardiovascular
  • Haemodynamic monitoring
  • Infection
  • Infectious disease
  • Mitochondria
  • Mitochondrial function
  • Models of disease
  • Sepsis
  • Sepsis Monitoring
  • Shock Monitoring
  • haemodynamic monitoring
  • haemodynamics
  • infection
  • multiple organ failure
  • sepsis