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Prof Martin Koltzenburg

Research Summary

Despite significant advances in our understanding of the neurobiology of nociception, pain continues to be a leading health problem and a significant area of unmet clinical need for novel analgesic drugs. Recent epidemiological surveys have revealed an overall prevalence of non-malignant pain of up to 20% in the general population. Many of these pains are the symptoms of trivial, self-limiting conditions, but there remains a large number of individuals suffering unrelenting severe pain. Careful clinical studies have identified an abnormal sensitivity of primary sensory neurons as a major culprit in chronic states. As a consequence much research in the unit aims to understand the mechanisms determining the normal and abnormal excitability of nociceptors. Translating the insights from laboratory investigations into human research projects we also investigate the psychophysical consequences of an abnormally increased nociceptor activity. Pain is also a clinical problem in childhood and prematurely born babies. Our work in animals has shown that the peripheral nociceptive nervous system starts to develop at a stage that corresponds to week 6 of human pregnancy and its maturation continues well into the postnatal period.

Research Activities

  • Genetics of Neurodegneration
  • The neurogenetics of neurodegenerative disease
  • peripheral nerve disease especially inherited neuropathies but also inflammatory neuropathies
  • the functions of sensory neurons and how phenotypic changes during development and disease contribute to pain and abnormal sensations

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Yoshida W,Seymour B,Koltzenburg M,Dolan RJ (2013) Uncertainty increases pain: evidence for a novel mechanism of pain modulation involving the periaqueductal gray. J Neurosci, 33(13), 5638 - 5646. 10.1523/JNEUROSCI.4984-12.2013.
  2. Rajakulendran S,Roberts J,Koltzenburg M,Hanna MG,Stewart H (2013) Deletion of chromosome 12q21 affecting KCNC2 and ATXN7L3B in a family with neurodevelopmental delay and ataxia. J Neurol Neurosurg Psychiatry. 10.1136/jnnp-2012-304555.
  3. Sinclair CD,Morrow JM,Miranda MA,Davagnanam I,Cowley PC,Mehta H,Hanna MG,Koltzenburg M,Yousry TA,Reilly MM,Thornton JS (2012) Skeletal muscle MRI magnetisation transfer ratio reflects clinical severity in peripheral neuropathies. J Neurol Neurosurg Psychiatry, 83(1), 29 - 32. 10.1136/jnnp.2011.246116.
  4. Maurer K,Bostock H,Koltzenburg M (2012) Protons regulate the excitability properties of rat myelinated sensory axons in vitro through block of persistent sodium currents. J Peripher Nerv Syst, 17(1), 102 - 111. 10.1111/j.1529-8027.2012.00381.x.
  5. Michell AW,Gaitatzis A,Burge J,Reilly MM,Kapoor R,Koltzenburg M (2012) Isolated motor conduction block associated with infliximab. J Neurol, 259(8), 1758 - 1760. 10.1007/s00415-012-6452-3.
  6. Park SB,Koltzenburg M,Lin CS,Kiernan MC (2012) Longitudinal assessment of oxaliplatin-induced neuropathy. Neurology, 78(2), 152. 10.1212/01.wnl.0000410913.88642.bf.
  7. Trip SA,Saifee T,Honan W,Chandrashekar H,Lunn MP,Yousry T,Koltzenburg M,Reilly MM (2012) Chronic immune sensory polyradiculopathy with cranial and peripheral nerve involvement. J Neurol, 259(6), 1238 - 1240. 10.1007/s00415-011-6326-0.
  8. Cesca F,Yabe A,Spencer-Dene B,Scholz-Starke J,Medrihan L,Maden CH,Gerhardt H,Orriss IR,Baldelli P,Al-Qatari M,Koltzenburg M,Adams RH,Benfenati F,Schiavo G (2012) Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems. Cell Death Differ, 19(2), 194 - 208. 10.1038/cdd.2011.141.
  9. Park U,Vastani N,Guan Y,Raja SN,Koltzenburg M,Caterina MJ (2011) TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception. J Neurosci, 31(32), 11425 - 11436. 10.1523/JNEUROSCI.1384-09.2011.
  10. Kachramanoglou C,Carlstedt T,Koltzenburg M,Choi D (2011) Self-mutilation in patients after nerve injury may not be due to deafferentation pain: a case report. Pain Med, 12(11), 1644 - 1648. 10.1111/j.1526-4637.2011.01242.x.
  11. Kasperavičiūtė D,Catarino CB,Chinthapalli K,Clayton LM,Thom M,Martinian L,Cohen H,Adalat S,Bockenhauer D,Pope SA,Lench N,Koltzenburg M,Duncan JS,Hammond P,Hennekam RC,Land JM,Sisodiya SM (2011) Uncovering genomic causes of co-morbidity in epilepsy: gene-driven phenotypic characterization of rare microdeletions. PLoS One, 6(8), e23182. 10.1371/journal.pone.0023182.
  12. Mantyh PW,Koltzenburg M,Mendell LM,Tive L,Shelton DL (2011) Antagonism of nerve growth factor-TrkA signaling and the relief of pain. Anesthesiology, 115(1), 189 - 204. 10.1097/ALN.0b013e31821b1ac5.
  13. Sinclair CD,Miranda MA,Cowley P,Morrow JM,Davagnanam I,Mehta H,Hanna MG,Koltzenburg M,Reilly MM,Yousry TA,Thornton JS (2011) MRI shows increased sciatic nerve cross sectional area in inherited and inflammatory neuropathies. J Neurol Neurosurg Psychiatry, 82(11), 1283 - 1286. 10.1136/jnnp.2010.211334.
  14. Cesca F,Yabe A,Spencer-Dene B,Arrigoni A,Al-Qatari M,Henderson D,Phillips H,Koltzenburg M,Benfenati F,Schiavo G (2011) Kidins220/ARMS is an essential modulator of cardiovascular and nervous system development. Cell Death Dis, 2, e226. 10.1038/cddis.2011.108.
  15. Tan SV,Matthews E,Barber M,Burge JA,Rajakulendran S,Fialho D,Sud R,Haworth A,Koltzenburg M,Hanna MG (2011) Refined exercise testing can aid DNA-based diagnosis in muscle channelopathies. Ann Neurol, 69(2), 328 - 340. 10.1002/ana.22238.
  16. Clark A,Koltzenburg M (2011) Microfluidic chambers provide a novel method to study the functional properties of sensory neuron terminals in culture NEUROMUSCULAR DISORDERS, 21, S16 - S16.
  17. Banks GT,Haas MA,Line S,Shepherd HL,Alqatari M,Stewart S,Rishal I,Philpott A,Kalmar B,Kuta A,Groves M,Parkinson N,Acevedo-Arozena A,Brandner S,Bannerman D,Greensmith L,Hafezparast M,Koltzenburg M,Deacon R,Fainzilber M,Fisher EM (2011) Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse. J Neurosci, 31(14), 5483 - 5494. 10.1523/JNEUROSCI.5244-10.2011.
  18. Shields K,Koltzenburg M (2010) PONM07 Nerve excitability parameters are biomarkers that differentiate between voltage-gated sodium blockers with differential mode of action. J Neurol Neurosurg Psychiatry, 81(11), e62. 10.1136/jnnp.2010.226340.180.
  19. Sinclair CDJ,Miranda MA,Cowley P,Morrow JM,Davagnanam I,Mehta H,Hanna MG,Koltzenburg M,Reilly MM,Yousry TA,Thornton JS (2010) Magnetic resonance imaging and sciatic nerve cross-sectional area in inherited and inflammatory neuropathies NEUROMUSCULAR DISORDERS, 20, S29 - S29.
  20. Tomlinson S,Burke D,Hanna M,Koltzenburg M,Bostock H (2010) In vivo assessment of HCN channel current (I(h)) in human motor axons. Muscle & Nerve, 41(2), 247 - 256. 10.1002/mus.21482.
  21. Laura M,Hutton EJ,Morrow JM,Blake J,Lunn MPT,Pareyson D,Koltzenburg M,Reilly MM (2009) PAIN AND SMALL FIBRE FUNCTION IN CMT 1A: PRELIMINARY RESULTS JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 14, 87 - 87.
  22. Alexander MD,Knight RK,Koltzenburg M (2009) A COMPARISON OF RING VERSUS BAR STIMULATING ELECTRODES FOR ORTHODROMIC SENSORY NERVE CONDUCTION STUDIES IN THE HANDS JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 80(1), 123 - 123.
  23. Clark AJ,Alqatari M,Shield K,Hantke J,Jessen KR,Koltzenburg M (2009) ANALYSIS OF SMALL FIBRE FUNCTON IN THE C3 MOUSE, A MODEL OF CMT1A JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 14, 34 - 34.
  24. Achilli F,Bros-Facer V,Williams HP,Banks GT,AlQatari M,Chia R,Tucci V,Groves M,Nickols CD,Seburn KL,Kendall R,Cader MZ,Talbot K,van Minnen J,Burgess RW,Brandner S,Martin JE,Koltzenburg M,Greensmith L,Nolan PM,Fisher EMC (2009) An ENU-induced mutation in mouse glycyl-tRNA synthetase (GARS) causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy. Disease Models and Mechanisms, 2(7-8), 359 - 373. 10.1242/dmm.002527.
  25. AlQatari M,Vastani N,Bros-Facer V,Groves M,Greensmith L,Fisher EM,Koltzenburg M (2009) A MUTATION OF THE CYTOPLASMIC DYNEIN HEAVY CHAIN GENE Dync1h1 CAUSES A SEVERE SENSORY NEUROPATHY JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 14, 6 - 6.
  26. Tomlinson SE,Burke D,Hanna MG,Bostock H,Koltzenburg M (2009) HOW REPRODUCIBLE ARE MULTIPLE NERVE EXCITABILITY PARAMETERS OVER TIME? JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 80(1), 121 - 121.
  27. Tomlinson SE,Burke D,Hanna MG,Koltzenburg M,Bostock H (2009) IN VIVO ASSESSMENT OF HCN CHANNEL FUNCTION (IH) IN HUMAN MOTOR AXONS JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 80(1), 117 - 118.
  28. Tomlinson SE,Burke D,Howells J,Trevillion L,Hanna MG,Koltzenburg M,Bostock H (2009) NOTCH APPEARANCE IN NERVE EXCITABILITY STUDIES: IDENTIFICATION AND IMPORTANCE JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 80(1), 121 - 121.
  29. Argyriou AA,Koltzenburg M,Polychronopoulos P,Papapetropoulos S,Kalofonos HP (2008) Peripheral nerve damage associated with administration of taxanes in patients with cancer Critical Reviews in Oncology/Hematology, 66(3), 218 - 228. 10.1016/j.critrevonc.2008.01.008.
  30. Maurer K,Bostock H,Nandi P,Koltzenburg M (2008) Effects of low-dose lidocaine on peripheral nerve excitability measured with threshold tracking in human and rat SWISS MED WKLY, 138(41-42), 13S - 13S.
  31. Andang M,Hjerling-Leffler J,Moliner A,Lundgren TK,Castelo-Branco G,Nanou E,Pozas E,Bryja V,Halliez S,Nishimaru H,Wilbertz J,Arenas E,Koltzenburg M,Charnay P,El MA,Ibanez CF,Ernfors P (2008) Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation Nature, 451(7177), 460 - 464.
  32. Schmalhofer WA,Calhoun J,Burrows R,Bailey T,Kohler MG,Weinglass AB,Kaczorowski GJ,Garcia ML,Koltzenburg M,Priest BT (2008) ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors Molecular Pharmacology, 74(5), 1476 - 1484.
  33. Hjerling-Leffler J,AlQatari M,Ernfors P,Koltzenburg M (2007) Emergence of functional sensory subtypes as defined by transient receptor potential channel expression Journal of Neuroscience, 27(10), 2435 - 2443. 10.1523/JNEUROSCI.5614-06.2007.
  34. Maurer K,Bostock H,Koltzenburg M (2007) A rat in vitro model for the measurement of multiple excitability properties of cutaneous axons Clinical Neurophysiology, 118(11), 2404 - 2412. 10.1016/j.clinph.2007.08.009.
  35. Tuffereau C,Schmidt K,Langevin C,Lafay F,Dechant G,Koltzenburg M (2007) The rabies virus glycoprotein receptor p75NTR is not essential for rabies virus infection Journal of Virology, 81(24), 13622 - 13630.
  36. Koltzenburg M,Yousry T (2007) Magnetic resonance imaging of skeletal muscle Current Opinion in Neurology, 20(5), 595 - 599.
  37. Koltzenburg M,Pokorny R,Gasser UE,Richarz U (2006) Differential sensitivity of three experimental pain models in detecting the analgesic effects of transdermal fentanyl and buprenorphine Pain, 126(1-3), 165 - 174.
  38. McMahon SB,Koltzenburg M (2006) Wall and Melzack's textbook of pain.
  39. Maurer K,Bostock H,Koltzenburg M (2006) An in vitro rat model to measure the excitability properties of peripheral sensory axons European Journal of Pain, 10 (Suppl S1), S64.
  40. Hjerling-Leffler J,AlQatari M,Ernfors P,Koltzenburg M (2006) Development of functional sensory neuron subtypes as defined by TRP channel expression Society for Neuroscience Abstracts, 32, 802.2.
  41. Munns C,Koltzenburg M (2006) Differential induction of cold sensitivity in sensory and sympathetic neurons by blockade of voltage-gated potassium channels Society for Neuroscience Abstracts, 32, 802.14.
  42. Diboun I,Wernisch L,Orengo CA,Koltzenburg M (2006) Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma BMC Genomics, 7, 252. 10.1186/1471-2164-7-252.
  43. Munns C,Alqatari M,Koltzenburg M (2006) Many cold sensitive peripheral neurons of the mouse do not express TRPM8 or TRPA1 Cell Calcium.
  44. Wessig C,Kenn W,Koltzenburg M,Bendszus M (2006) Denervation hypertrophy may mimic local tumor spread on magnetic resonance imaging Muscle Nerve, 34(1), 108 - 110.
  45. Aquino JB,Hjerling-Leffler J,Koltzenburg M,Edlund T,Villar MJ,Ernfors P (2006) In vitro and in vivo differentiation of boundary cap neural crest stem cells into mature Schwann cells Experimental Neurology, 198(2), 438 - 449.
  46. Maurer K,Vastani N,Koltzenburg M (2006) Activity dependent excitability changes selectively modulate the mechanosensitivity of unmyelinated nociceptors Society for Neuroscience Abstracts, 32, 442.8.
  47. Maurer K,Vastani N,Koltzenburg M (2006) Activity dependent excitability changes selectively modulate the mechanosensitivity of unmyelinated nociceptors European Journal of Pain, 10 (Suppl S1), S91.
  48. Wasner G,Koltzenburg M,Jorum E,Baron R,Jensen TS (2006) Cold allodynia: from the molecule to the clinic, 651 - 661.
  49. Vastani N,Munns C,Koltzenburg M (2006) Oxaliplatin induces novel cold sensitivity in sensory neurons European Journal of Pain, 10 (Suppl S1), S92.
  50. Scadding JW,Koltzenburg M (2006) Painful peripheral neuropathies, 973 - 999.

Qualifications

  • 1989: Doctor of Medicine, To be updated

Keywords

  • Calcium imaging
  • Cell culture
  • Chronic pain syndromes
  • Confocal microscopy
  • Electroencephalography (EEG)
  • Electromyography
  • Extracellular recording - acute
  • Fluorescence microscopy techniques
  • Gene expression
  • Gene expression profiling - single cell
  • Gene expression profiling - tissue level
  • Histology
  • Immunohistochemistry
  • Ion channels
  • Laser Capture
  • Light microscopic techniques
  • Microarrays
  • Microdissection
  • Neural stem cells
  • Neuropathy
  • Neurophysiology
  • Pain
  • Patch-clamp recording
  • Psychophysics
  • Randomized Controlled Trials (RCTs)
  • Sensory neuron function in health and disease
  • Transcranial Magnetic Stimulation (TMS)