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Dr Mike Hubank

  • Telephone:

    2079052266

  • Extension:

    42266

  • Fax:

    2078138100

  • Email:

    m.hubank@ucl.ac.uk

  • Webpage:

    http://www.genomics.ucl.ac.uk/

  • Address:

    Institute of Child Health; 30,
    Guilford St; London,
    London,
    WC1N 1EH

  • Appointments:

    Senior Lecturer, ICH - Molecular Haem & Cancer Biology, Dept of Cancer

Summary

During my career, I have tried to blend technological progress with biological discovery, developing a skill set highly applicable in interdisciplinary collaborations. As a post-doc at Yale, in the laboratory of Dr David Schatz (Section of Immunobiology, Head, Dr Richard Flavell), I developed the highly cited cDNA RDA technique for the detection of differentially expressed genes1,2. Returning to the UK in 1997 I continued the theme of transcriptional regulation as a Research Fellow at the University of Sussex, focussing on the response to DNA damage. In a number of papers I helped delineate and clarify several aspects of the p53 signalling pathway3. In 1999 I took up a lectureship at UCL Institute of Child Health, continuing to publish on the DNA damage response and also developing an interest in highly parallel transcriptional assays. I established the ICH Gene Microarray Centre in 2000, which  subsequently developed into UCL Genomics (www.genomics.ucl.ac.uk).

Research Summary

My research focuses on two areas, the global analysis of transcriptional responses and the development and application of genomic methods to biological and clinical questions. 

Research Activities

  • Bioinformatics - prediction of protein functions and functional networks
  • Biology of renal and urinary tract malformations,
  • Gene Therapy and stem cell manipulation
  • Genetics of early CNS malformations, cleft lip and cleft palate
  • Immunopathogenesis of paediatric autoimmune diseas
  • Mechanisms of oncogenesis in infant and childhood leukaemia
  • The role of STAT1 and STAT3 in the cell cycle checkpoint response to DNA damage
  • Transcription factors in early forebrain and pituitary development

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Long DA,Kolatsi-Joannou M,Price KL,Dessapt-Baradez C,Huang JL,Papakrivopoulou E,Hubank M,Korstanje R,Gnudi L,Woolf AS (2013) Albuminuria is associated with too few glomeruli and too much testosterone. Kidney Int. 10.1038/ki.2013.45.
  2. Lopes LR,Zekavati A,Syrris P,Hubank M,Giambartolomei C,Dalageorgou C,Jenkins S,McKenna W,Uk10k Consortium ,Plagnol V,Elliott PM (2013) Genetic complexity in hypertrophic cardiomyopathy revealed by high-throughput sequencing. J Med Genet, 50(4), 228 - 239. 10.1136/jmedgenet-2012-101270.
  3. Lescai F,Bonfiglio S,Bacchelli C,Chanudet E,Waters A,Sisodiya SM,Kasperavičiute D,Williams J,Harold D,Hardy J,Kleta R,Cirak S,Williams R,Achermann JC,Anderson J,Kelsell D,Vulliamy T,Houlden H,Wood N,Sheerin U,Tonini GP,Mackay D,Hussain K,Sowden J,Kinsler V,Osinska J,Brooks T,Hubank M,Beales P,Stupka E (2012) Characterisation and Validation of Insertions and Deletions in 173 Patient Exomes PLoS ONE, 7(12).
  4. Stanescu HC,Arcos-Burgos M,Medlar A,Bockenhauer D,Kottgen A,Dragomirescu L,Voinescu C,Patel N,Pearce K,Hubank M,Stephens HA,Laundy V,Padmanabhan S,Zawadzka A,Hofstra JM,Coenen MJ,den Heijer M,Kiemeney LA,Bacq-Daian D,Stengel B,Powis SH,Brenchley P,Feehally J,Rees AJ,Debiec H,Wetzels JF,Ronco P,Mathieson PW,Kleta R (2011) Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. N Engl J Med, 364(7), 616 - 626. 10.1056/NEJMoa1009742.
  5. Menghi F,Jacques TS,Barenco M,Schwalbe EC,Clifford SC,Hubank M,Ham J (2011) Genome-wide analysis of alternative splicing in medulloblastoma identifies splicing patterns characteristic of normal cerebellar development Cancer Res., 71(6), 2045 - 2055. 10.1158/0008-5472.CAN-10-2519.
  6. Ferraz-de-Souza B,Hudson-Davies RE,Lin L,Parnaik R,Hubank M,Dattani MT,Achermann JC (2011) Sterol O-acyltransferase 1 (SOAT1, ACAT) is a novel target of steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) in the human adrenal. J Clin Endocrinol Metab, 96(4), E663 - E668. 10.1210/jc.2010-2021.
  7. Ferraz-de-Souza B,Lin L,Shah S,Jina N,Hubank M,Dattani MT,Achermann JC (2011) ChIP-on-chip analysis reveals angiopoietin 2 (Ang2, ANGPT2) as a novel target of steroidogenic factor-1 (SF-1, NR5A1) in the human adrenal gland. FASEB J, 25(4), 1166 - 1175. 10.1096/fj.10-170522.
  8. de Boer J,Yeung J,Ellu J,Ramanujachar R,Bornhauser B,Solarska O,Hubank M,Williams O,Brady HJ (2011) The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors. Leukemia, 25(2), 321 - 330. 10.1038/leu.2010.253.
  9. Waters A,Lescai F,Christou S,Chanudet E,Charu D,Kleta R,Hubank M,Stupka E,Winey M,Beales P (2011) Whole exome sequencing identifies the genetic cause of a new ciliopathy syndrome PEDIATR NEPHROL, 26(9), 1574 - 1575.
  10. Kristiansen M,Menghi F,Hughes R,Hubank M,Ham J (2011) Global analysis of gene expression in NGF-deprived sympathetic neurons identifies molecular pathways associated with cell death. BMC Genomics, 12, 551. 10.1186/1471-2164-12-551.
  11. Lakowski J,Han YT,Pearson RA,Gonzalez-Cordero A,West EL,Gualdoni S,Barber AC,Hubank M,Ali RR,Sowden JC (2011) Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression. Stem Cells, 29(9), 1391 - 1404. 10.1002/stem.694.
  12. Barry SP,Lawrence KM,McCormick J,Soond SM,Hubank M,Eaton S,Sivarajah A,Scarabelli TM,Knight RA,Thiemermann C,Latchman DS,Townsend PA,Stephanou A (2010) New targets of urocortin-mediated cardioprotection. J Mol Endocrinol, 45(2), 69 - 85. 10.1677/JME-09-0148.
  13. Williams RD,Al-Saadi R,Chagtai T,Popov S,Messahel B,Sebire N,Gessler M,Wegert J,Graf N,Leuschner I,Hubank M,Jones C,Vujanic G,Pritchard-Jones K,Children's Cancer and Leukaemia Group ,SIOP Wilms' Tumour Biology Group (2010) Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor. Clin Cancer Res, 16(7), 2036 - 2045. 10.1158/1078-0432.CCR-09-2890.
  14. Woodward MJ,de Boer J,Heidorn S,Hubank M,Kioussis D,Williams O,Brady HJ (2010) Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes. Cell Death Differ, 17(2), 316 - 323. 10.1038/cdd.2009.125.
  15. MONCRIEFFE H,Hinks A,Ursu S,Kassoumeri L,Etheridge A,Hubank M,Martin P,Weiler T,Glass DN,Thompson SD,Thomson W,Wedderburn LR (2010) Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype. Pharmacogenet Genomics., 20(11), 665 - 676.
  16. Lyons R,Williams O,Morrow M,Sebire N,Hubank M,Anderson J (2010) The RAC specific guanine nucleotide exchange factor Asef functions downstream from TEL-AML1 to promote leukaemic transformation Leukemia Research, 34(1), 109 - 115. 10.1016/j.leukres.2009.06.032.
  17. Hunter P,Nistala K,Jina N,Eddaoudi A,Thomson W,Hubank M,Wedderburn LR (2010) Biological Predictors of Extension of Oligoarticular Juvenile Idiopathic Arthritis from Synovial Fluid Cellular Composition and Gene Expression Arthritis and Rheumatism, 62(3), 896 - 907.
  18. Broderick P,Hubank M,Sinclair A (2009) [Effects of Epstein-Barr virus on host gene expression in Burkitt's lymphoma cell lines]. Ai Zheng, 28(8), 813 - 821.
  19. Bockenhauer D,Feather S,Stanescu HC,Bandulik S,Zdebik AA,Reichold M,Tobin J,Lieberer E,Sterner C,Landoure G,Ruchi A,Sirimanna T,Thompson D,Cross JH,van't Hoff W,Al Masri O,Tullus K,Yeung S,Anikster Y,Klootwijk E,Hubank M,Dillon MJ,Heitzmann D,Arcos-Burgos M,Knepper MA,Dobbie A,Gahl WA,Warth R,Sheridan E,Kleta R (2009) Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations New England Journal of Medicine, 360(19), 1960 - 1970.
  20. Risebro CA,Searles RG,Melville AA,Ehler E,Jina N,Shah S,Pallas J,Hubank M,Dillard M,Harvey NL,Schwartz RJ,Chien KR,Oliver G,Riley PR (2009) Prox1 maintains muscle structure and growth in the developing heart. Development, 136(3), 495 - 505.
  21. Barenco M,Brewer D,Papouli E,Tomescu D,Callard R,Stark J,Hubank M (2009) Dissection of a complex transcriptional response using genome-wide transcriptional modelling. Mol Syst Biol, 5, 327. 10.1038/msb.2009.84.
  22. Barenco M,Papouli E,Shah S,Brewer D,Miller CJ,Hubank M (2009) rHVDM: an R package to predict the activity and targets of a transcription factor. Bioinformatics, 25(3), 419 - 420. 10.1093/bioinformatics/btn639.
  23. Howe SJ,Mansour MR,Schwarzwaelder K,Bartholomae C,Hubank M,Kempski H,Brugman MH,Pike O,K C,S D,Ridder D,Gilmour KC,Adams S,Thornhill SI,Parsley KL,Staal FJ,Gale RE,Linch DC,Bayford J,Brown L,Quaye M,Kinnon C,Ancliff P,Webb DK,Schmidt M,von KC,Gaspar HB,Thrasher AJ (2009) Insertional mutagenesis combined with acquired somatic mutations causes leukaemogenesis following gene therapy of SCID-X1 patients Journal of Clinical Investigation, 118(9), 3143 - 3150.
  24. Hubank M (2009) Editorial. Brief Funct Genomic Proteomic, 8(3), 167 - 169. 10.1093/bfgp/elp030.
  25. Dimmer EC,Huntley RP,Barrell DG,Binns D,Draghici S,Camon EB,Hubank M,Talmud PJ,Apweiler R,Lovering RC (2008) The Gene Ontology - Providing a Functional Role in Proteomic Studies Proteomics.
  26. Bungay A,Selden C,Brown D,Malik R,Hubank H,Hodgson H (2008) Microarray analysis of mitogenic effects of T3 on the rat liver Journal of Gastroenterology and Hepatology.
  27. Schwab R,Bussolari R,Corvetta D,Chayka O,Santilli G,Kwok JM,Ferrari-Amorotti G,Tonini GP,Iacoviello L,Bertorelle R,Menin C,Hubank M,Calabretta B,Sala A (2008) Isolation and functional assessment of common, polymorphic variants of the B-MYB proto-oncogene associated with a reduced cancer risk Oncogene, 27(20), 2929 - 2933.
  28. Lovering RC,Dimmer E,Khodiyar VK,Barrell DG,Scambler P,Hubank M,Apweiler R,Talmud PJ (2008) Cardiovascular GO annotation initiative year 1 report: why cardiovascular GO? Proteomics, 8(10), 1950 - 1953.
  29. Howe SJ,Mansour M,Brugman M,Pike-Overzet K,Hubank M,Jina N,de Ridder D,Staal F,Baum C,Kinnon C,Gaspar HB,Thrasher AJ (2008) Molecular analysis of a severe adverse event in the UKSCID-X1 gene therapy clinical trial Human Gene Therapy, 19(4), 82.
  30. Brewer D,Barenco M,Callard R,Hubank M,Stark J (2008) Fitting ordinary differential equations to short time course data. Philos Trans A Math Phys Eng Sci, 366(1865), 519 - 544. 10.1098/rsta.2007.2108.
  31. Lovering R,Scambler P,Hubank M,Apweiler R,Talmud PJ (2008) CARDIOVASCULAR GENE ONTOLOGY INITIATIVE ATHEROSCLEROSIS SUPP, 9(1), 101 - 101.
  32. Barry SP,Jayasinghe SN,Pericleous C,Hubank M,Latchman DS,Stephanou A (2008) Gene expression studies on bio-electrosprayed primary cardiac myocytes Biotechnology Journal, 3, 530 - 535.
  33. Offman J,Jina N,Theron T,Pallas J,Hubank M,Lehmann A (2008) Transcriptional changes in trichothiodystrophy cells DNA Repair, 7(8), 1364 - 1371. 10.1016/j.dnarep.2008.05.002.
  34. Wang Q,Williamson M,Bott S,Brookman-Amissah N,Freeman A,Nariculam J,Hubank MJF,Ahmed A,Masters JR (2007) Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer Oncogene, 26(45), 6560 - 6565. 10.1038/sj.onc.1210472.
  35. Price KL,Long DA,Jina N,Liapis H,Hubank M,Woolf AS,Winyard PJ (2007) Microarray interrogation of human metanephric mesenchymal cells highlights potentially important molecules in vivo Physiological Genomics, 28(2), 193 - 202.
  36. Goold R,Hubank M,Hunt A,Holton J,Menon RP,Revesz T,Pandolfo M,Matilla-Dueñas A (2007) Down-regulation of the dopamine receptor D2 in mice lacking ataxin 1. Hum Mol Genet, 16(17), 2122 - 2134. 10.1093/hmg/ddm162.
  37. Ogilvie EM,Khan A,Hubank M,Kellam P,Woo P (2007) Specific gene expression profiles in systemic juvenile idiopathic arthritis Arthritis Rheum, 56(6), 1954 - 1965.
  38. Sivagnanasundaram S,Fletcher D,Hubank M,Illingworth E,Skuse D,Scambler P (2007) Differential gene expression in the hippocampus of the Df1/+ mice: A model for 22q11.2 deletion syndrome and schizophrenia Brain Res., 1139, 48 - 59.
  39. Barenco M,Tomescu D,Brewer D,Callard R,Stark J,Hubank M (2006) Ranked prediction of p53 targets using hidden variable dynamic modeling. Genome Biol, 7(3), R25. 10.1186/gb-2006-7-3-r25.
  40. Price KL,Long DA,Jina N,Liapis H,Hubank M,Woolf AS,Winyard PJ (2006) Microarray interrogation of human metanephric mesenchymal cells highlights potentially important molecules in vivo Physiol Genomics.
  41. Evans PM,Woodbine L,Riballo E,Gennery AR,Hubank MJF,Jeggo PA (2006) Radiation induced delayed cell death in a hypomorphic Artemis cell line. Human Molecular Genetics, 15(8), 1303 - 1311. 10.1093/hmg/ddl050.
  42. Barenco M,Stark J,Brewer D,Tomescu D,Callard R,Hubank M (2006) Correction of scaling mismatches in oligonucleotide microarray data. BMC Bioinformatics, 7, 251. 10.1186/1471-2105-7-251.
  43. Nabarro S,Himoudi N,Papanastasiou A,Gilmour K,Gibson S,Sebire N,Thrasher A,Blundell MP,Hubank M,Canderan G,Anderson J (2005) Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein. J Exp Med, 202(10), 1399 - 1410. 10.1084/jem.20050730.
  44. Fauchon MAC,Pell TJ,Baxter GF,Yellon DM,Latchman DS,Hubank MF,Mayne LV (2005) Representational difference analysis of cDNA identifies novel genes expressed following preconditioning of the heart Experimental and Molecular Medicine, 37(4), 311 - 322.
  45. van Delft FW,Bellotti T,Luo ZY,Jones LK,Patel N,Yiannikouris O,Hill AS,Hubank M,Kempski H,Fletcher D,Chaplin T,Foot N,Young BD,Hann IM,Gammerman A,Saha V (2005) Prospective gene expression analysis accurately subtypes acute leukaemia in children and establishes a commonality between hyperdiploidy and t(12;21) in acute lymphoblastic leukaemia British Journal of Haematology, 130(1), 26 - 35.
  46. Suarez-Merino B,Hubank M,Revesz T,Harkness W,Hayward R,Thompson D,Darling JL,Thomas DGT,Warr TJ (2005) Microarray analysis of pediatric ependymoma identifies a cluster of 112 candidate genes including four transcripts at 22q12.1-q13.3 Neuro-Oncology, 7(1), 20 - 31. 10.1215/S1152851704000596.
  47. Chowdhury T,Moulding D,Jina N,Hubank M,Williams O,Brady HJM (2005) Identification of target genes of the oncogenic transcription factors MLL-ENL and MLL-AF9 in myeloid progenitor cells British Journal of Haematology, 129, 100.
  48. Lawrence KM,Kabir AM,Bellahcene M,Davidson S,Cao XB,McCormick J,Mesquita RA,Carroll CJ,Chanalaris A,Townsend PA,Hubank M,Stephanou A,Knight RA,Marber MS,Latchman DS (2005) Cardioprotection mediated by urocortin is dependent on PKCepsilon activation. The FASEB Journal, 19(7), 831 - 833.
  49. Marston E,Weston V,Hubank M,Lawson S,Darbyshire P,Stankovic T (2005) Apoptotic resistance in childhood acute lymphoblastic leukaemia may involve upregulation of the phosphatidylinositol 3-kinase pathway British Journal of Haematology, 129, 67.
  50. Alvi AJ,Austen B,Weston VJ,Fegan C,MacCallum D,Gianella-Borradori A,Lane DP,Hubank M,Powell JE,Wei WB,Taylor AMR,Moss PAH,Stankovic T (2005) A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival Blood, 105(11), 4484 - 4491.

Biography

During my career, I have tried to blend technological progress with biological discovery, developing a skill set highly applicable in interdisciplinary collaborations. As a post-doc at Yale, in the laboratory of Dr David Schatz (Section of Immunobiology, Head, Dr Richard Flavell), I developed the highly cited cDNA RDA technique for the detection of differentially expressed genes1,2. Returning to the UK in 1997 I continued the theme of transcriptional regulation as a Research Fellow at the University of Sussex, focussing on the response to DNA damage. In a number of papers I helped delineate and clarify several aspects of the p53 signalling pathway3. In 1999 I took up a lectureship at UCL Institute of Child Health, continuing to publish on the DNA damage response and also developing an interest in highly parallel transcriptional assays. I established the ICH Gene Microarray Centre in 2000, which  subsequently developed into UCL Genomics (www.genomics.ucl.ac.uk).

Qualifications

  • 1989: Doctor of Philosophy, University College London
  • 1985: Bachelor of Arts (Honours), University of Cambridge