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Prof Monty Mythen

Research Summary

Pathogenesis of post-operative organ dysfunction and therapeutic interventions that improve outcome. Haemodynamic measurements and fluid therapy.

Research Activities

  • Critical Care Medicine

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Van Der Linden P,James M,Mythen M,Weiskopf RB (2013) Safety of modern starches used during surgery. Anesth Analg, 116(1), 35 - 48. 10.1213/ANE.0b013e31827175da.
  2. Wade D,Hardy R,Howell D,Mythen M (2013) Identifying clinical and acute psychological risk factors for PTSD after critical care: A systematic review. Minerva Anestesiol.
  3. Knott A,Pathak S,McGrath JS,Kennedy R,Horgan A,Mythen M,Carter F,Francis NK (2012) Consensus views on implementation and measurement of enhanced recovery after surgery in England: Delphi study. BMJ Open, 2(6). 10.1136/bmjopen-2012-001878.
  4. Burdett E,Dushianthan A,Bennett-Guerrero E,Cro S,Gan TJ,Grocott MP,James MF,Mythen MG,O'Malley CM,Roche AM,Rowan K (2012) Perioperative buffered versus non-buffered fluid administration for surgery in adults. Cochrane Database Syst Rev, 12, CD004089. 10.1002/14651858.CD004089.pub2.
  5. Grocott MP,Dushianthan A,Hamilton MA,Mythen MG,Harrison D,Rowan K,Optimisation Systematic Review Steering Group (2012) Perioperative increase in global blood flow to explicit defined goals and outcomes following surgery. Cochrane Database Syst Rev, 11, CD004082. 10.1002/14651858.CD004082.pub5.
  6. Smith GC,Kotwinski P,Sanders J,Cooper J,Ma L,Jones A,Mythen MG,Montgomery HE,Pennell DJ (2012) THE BREAST CANCER, EARLY DISEASE: TOXICITY FROM THERAPY WITH EPIRUBICIN REGIMENS "C CARDIAC ASSESSMENT AND RISK EVALUATION (BETTER-CARE), CARDIOVASCULAR MAGNETIC RESONANCE (CMR) SUB-STUDY: CYCLE 1 CHANGES PREDICT LATE ANTHRACYCLINE CARDIOTOXICITY HEART, 98, A12 - A13. 10.1136/heartjnl-2012-301877b.18.
  7. Wade DM,Howell DC,Weinman JA,Hardy RJ,Mythen MG,Brewin CR,Borja-Boluda S,Matejowsky CF,Raine RA (2012) Investigating risk factors for psychological morbidity three months after intensive care: a prospective cohort study. Crit Care, 16(5), R192. 10.1186/cc11677.
  8. Sanders JS,Skipworth JR,Cooper JA,Brull DJ,Humphries SE,Mythen M,Montgomery HE (2012) Duration of preceding hypertension is associated with prolonged length of ICU stay. Int J Cardiol, 157(2), 180 - 184. 10.1016/j.ijcard.2010.12.011.
  9. Grocott MP,Martin DS,Mythen MG (2012) Enhanced recovery pathways as a way to reduce surgical morbidity. Curr Opin Crit Care, 18(4), 385 - 392. 10.1097/MCC.0b013e3283558968.
  10. McMorrow RC,Windsor JS,Hart ND,Richards P,Rodway GW,Ahuja VY,O'Dwyer MJ,Mythen MG,Grocott MP,Caudwell Xtreme Everest Research Group (2012) Closed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m). Anaesthesia, 67(8), 875 - 880. 10.1111/j.1365-2044.2012.07152.x.
  11. Martin DS,Pate JS,Vercueil A,Doyle PW,Mythen MG,Grocott MP,Caudwell Xtreme Everest Research Group (2012) Reduced coagulation at high altitude identified by thromboelastography. Thromb Haemost, 107(6), 1066 - 1071. 10.1160/TH12-01-0004.
  12. Sanders J,Keogh BE,Van der Meulen J,Browne JP,Treasure T,Mythen MG,Montgomery HE (2012) The development of a postoperative morbidity score to assess total morbidity burden after cardiac surgery. J Clin Epidemiol, 65(4), 423 - 433. 10.1016/j.jclinepi.2011.11.004.
  13. Fawcett WJ,Mythen MG,Scott MJ (2012) Enhanced recovery: more than just reducing length of stay? Br J Anaesth, 109(5), 671 - 674. 10.1093/bja/aes358.
  14. Levett DZ,Fernandez BO,Riley HL,Martin DS,Mitchell K,Leckstrom CA,Ince C,Whipp BJ,Mythen MG,Montgomery HE,Grocott MP,Feelisch M,Caudwell Extreme Everest Res Grp (2011) The role of nitrogen oxides in human adaptation to hypoxia SCI REP-UK, 1. 10.1038/srep00109.
  15. Grace C,Kuper M,Weldon S,Lees J,Modasia R,Mythen M (2011) Service redesign. Fitter, faster: improved pathways speed up recovery. Health Serv J, 121(6255), 28 - 30.
  16. Sanders J,Patel S,Cooper J,Berryman J,Farrar D,Mythen M,Montgomery HE (2011) Red blood cell storage is associated with length of stay and renal complications after cardiac surgery. Transfusion, 51(11), 2286 - 2294. 10.1111/j.1537-2995.2011.03170.x.
  17. Mythen M (2011) Fit for surgery? Anesth Analg, 112(5), 1002 - 1004. 10.1213/ANE.0b013e318203250f.
  18. Moonesinghe SR,Mythen MG,Grocott MP (2011) High-risk surgery: epidemiology and outcomes. Anesth Analg, 112(4), 891 - 901. 10.1213/ANE.0b013e3181e1655b.
  19. Sanders J,Toor IS,Yurik TM,Keogh BE,Mythen M,Montgomery HE (2011) Tissue oxygen saturation and outcome after cardiac surgery. Am J Crit Care, 20(2), 138 - 145. 10.4037/ajcc2011739.
  20. Kehlet H,Mythen M (2011) Why is the surgical high-risk patient still at risk? Br J Anaesth, 106(3), 289 - 291. 10.1093/bja/aeq408.
  21. Ackland GL,Moran N,Cone S,Grocott MP,Mythen MG (2011) Chronic kidney disease and postoperative morbidity after elective orthopedic surgery. Anesth Analg, 112(6), 1375 - 1381. 10.1213/ANE.0b013e3181ee8456.
  22. McMorrow RC,Windsor JS,Mythen MG,Grocott MP,Caudwell Xtreme Everest Research Group (2011) A novel ambulatory closed circuit breathing system for use during exercise. Anaesthesia, 66(5), 348 - 353. 10.1111/j.1365-2044.2011.06698.x.
  23. Ackland GL,Harris S,Ziabari Y,Grocott M,Mythen M,SOuRCe Investigators (2010) Revised cardiac risk index and postoperative morbidity after elective orthopaedic surgery: a prospective cohort study. Br J Anaesth, 105(6), 744 - 752. 10.1093/bja/aeq245.
  24. Grocott MPW,Martin DS,Wilson MH,Mitchell K,Dhillon S,Mythen MG,Montgomery HE,Levett DZH,Caudwell Xtreme Everest Res Grp (2010) Caudwell Xtreme Everest Expedition HIGH ALT MED BIOL, 11(2), 133 - 137. 10.1089/ham.2009.1093.
  25. Bennett-Guerrero E,Gan TJ,Roche AM,Mythen MG (2010) Comment on reference to maximum dose for starch. Anesthesiology, 112(3), 757 - 758. 10.1097/ALN.0b013e3181cbd20b.
  26. Boldt J,Christian Ertmer MD,Frietsch PDT,Gan PTJ,Haljamae PH,Hillmann DR,Holte DK,Kretz PDF-J,Krzanicki DD,Mythen PDMG,Rehberg S,Sakka SG,Stephens DRCM,Stocker PDR,Stover P-DDJF,Suttner PDDS,Tircoveanu R,Aken HV,Linden PPVD,Wahl K,Wappler PDF,Westphal M (2010) Volume Replacement, 15 - 171.
  27. Hollowell J,Grocott M,Hardy R,Hadad F,Mythen M,Raine R (2010) Major elective joint replacement surgery:socioeconomic variations in surgical risk, postoperative morbidity and length of stay Journal of Evaluation in Clinical Practice, 16, 529 - 538.
  28. Grocott MP,Martin DS,Wilson MH,Mitchell K,Dhillon S,Mythen MG,Montgomery HE,Levett DZ,Caudwell Xtreme Everest Research Group (2010) Caudwell xtreme Everest expedition. High Alt Med Biol, 11(2), 133 - 137. 10.1089/ham.2009.1093.
  29. Mythen MM,Burdett E,Stephens RCM,Walker D (2010) Anaesthesiology.
  30. Levett DZ,Martin DS,Wilson MH,Mitchell K,Dhillon S,Rigat F,Montgomery HE,Mythen MG,Grocott MP,Caudwell Xtreme Everest Research Group (2010) Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia. BMC Med Res Methodol, 10, 98. 10.1186/1471-2288-10-98.
  31. Martin DS,Khosravi M,Grocott MPW,Mythen MG (2010) Concepts in hypoxia reborn CRIT CARE, 14(4). 10.1186/cc9078.
  32. Edwards LM,Murray AJ,Tyler DJ,Kemp GJ,Holloway CJ,Robbins PA,Neubauer S,Levett D,Montgomery HE,Grocott MP,Clarke K (2010) The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition PLoS.One., 5(5), e10681.
  33. Moonesinghe SR,Mythen MG,Grocott MP (2009) Patient-related risk factors for postoperative adverse events. Curr Opin Crit Care, 15(4), 320 - 327. 10.1097/MCC.0b013e32832e067c.
  34. Gill R,Herbertson M,Vuylsteke A,Olsen PS,von Heymann C,Mythen M,Sellke F,Booth F,Schmidt TA (2009) Safety and efficacy of recombinant activated factor VII: a randomized placebo-controlled trial in the setting of bleeding after cardiac surgery. Circulation, 120(1), 21 - 27. 10.1161/CIRCULATIONAHA.108.834275.
  35. Sanders J,Toor I,Yurik T,Smith A,Keogh BE,Montgomery HE,Mythen M (2009) A simple measure to reduce the incidence of heparin induced thrombocytopenia (HIT) in cardiac intensive care patients - a retrospective observational analysis ANAESTHESIA, 64(1), 109 - 109. 10.1111/j.1365-2044.2008.05748_3.x.
  36. Grocott MP,Martin DS,Levett DZ,McMorrow R,Windsor J,Montgomery HE (2009) Arterial blood gases and oxygen content in climbers on Mount Everest N.Engl.J.Med., 360(2), 140 - 149.
  37. Mythen MG (2009) Postoperative gastrointestinal tract dysfunction: an overview of causes and management strategies. Cleve Clin J Med, 76 Suppl 4, S66 - S71. 10.3949/ccjm.76.s4.11.
  38. Mythen M (2009) Pre-operative coronary revascularisation before non-cardiac surgery: think long and hard before making a pre-operative referral. Anaesthesia, 64(10), 1048 - 1050. 10.1111/j.1365-2044.2009.06056.x.
  39. Powell-Tuck J,Gosling P,Lobo DN,Carlson GL,Allison SP,Gore M,Lewington AJ,Pearse RL,Mythen MG (2009) Intravenous fluids in surgery Authors of guideline respond BRIT MED J, 339. 10.1136/bmj.b3030.
  40. Martin DS,Levett DZ,Mythen M,Grocott MP,Caudwell Xtreme Everest Research Group (2009) Changes in skeletal muscle oxygenation during exercise measured by near-infrared spectroscopy on ascent to altitude. Crit Care, 13 Suppl 5, S7. 10.1186/cc8005.
  41. Ackland GL,Harrington J,Downie P,Holding JW,Singh-Ranger D,Griva K,Mythen MG,Newman SP (2008) Dehydration induced by bowel preparation in older adults does not result in cognitive dysfunction. Anesth Analg, 106(3), 924 - 929. 10.1213/ane.0b013e3181615247.
  42. Broadhead M,Mythen M (2008) Monitoring, 295 - 311.
  43. Sanders J,Martin D,Smith A,Keogh B,Mutch M,Hamilton M,Montgomery H,Mythen M (2008) Tissue oxygen saturation during anaesthesia, cardiopulmonary bypass and intensive care stay for cardiac surgery, 12(Suppl.2), 71.
  44. Grocott M,Martin D,Levett D,Montgomery H,Mythen M (2008) Caudwell Xtreme Everest Anaesthesia and Analgesia, Suppl 106(4), 81 - 84.
  45. Mythen M (2008) Low Volume versus High Volume Resuscitation in Trauma, 181 - 188.
  46. Grocott MP,Browne JP,Van der Meulen J,Matejowsky C,Mutch M,Hamilton MA,Levett DZ,Emberton M,Haddad FS,Mythen MG (2007) The Postoperative Morbidity Survey was validated and Used to Describe Morbidity after Major Surgery Journal of Clinical Epidemiology, 60(9), 919 - 928. 10.1016/j.jclinepi.2006.12.003.
  47. Grocott M,Richardson A,Montgomery H,Mythen M (2007) Caudwell Xtreme Everest: a field study of human adaptation to hypoxia Critical Care, 11(4), 151 - 152.
  48. Usher SM,Walker DA,Mythen MG (2007) Doppler cardiac output monitoring: a tool for all physicians. Br J Hosp Med (Lond), 68(3), 126 - 130.
  49. Ackland G,Mythen M (2007) Physiology of the Gastrointestinal Tract Including Splanchnic Blood Flow and Tonometry, 1 - 12.
  50. Mythen M,Soni N (2007) Industry Sponsorship, 94 - 110.

Qualifications

  • 1984: Bachelor of Medicine/Bachelor of Surgery, Middlesex Hospital Medical School

Keywords

  • Anaesthesia
  • Cardiac Output
  • Cardiopulmonary
  • Critical care
  • Doppler
  • Excercise
  • Fluid management
  • Gastric
  • Major surgery
  • Measurement
  • Muscle
  • Near Infra-Red Spectroscopy
  • Outcomes
  • Splanchnic perfusion
  • Testing
  • Tonometry