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Prof Linda Partridge

  • Telephone:

    020 7679 4380

  • Extension:

    32983

  • Email:

    linda.partridge@ucl.ac.uk

  • Webpage:

    http://www.ucl.ac.uk/iha

  • Address:

    Institute of Healthy Ageing Darwin Building,
    Gower Street,
    London,
    WC1E 6BT

  • Appointments:

    Professor of Genetics and Biometry, Genetics, Evolution & Environment, Div of Biosciences

Research Summary

The aim of our research is to discover genes and mechanisms that determine the rate of ageing. We collaborate with other laboratories to determine if these processes show evolutionary conservation, most of our work is conducted with the fruit fly Drosophila and through comparison with C. elegans and then with the mouse. Our work focuses particularly on the insulin/IGF-like signalling pathway, dietary restriction and resistance to stress. We are interested also in the physiological mechanisms that force organisms to make trade-offs, such as that between high nutrient intake and high reproductive rate, on one hand, and slow ageing on the other.

Research Activities

  • Cell signalling
  • Genetics of ageing and age-related disease in Caenorhabditis elegans
  • Mechanisms regulating lymphocyte differentiation i
  • Quantitative proteomics of age related neurodegeneration in Drosophila melanogaster
  • The central nervous system regulation of energy homeostasis

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Lee SF,Eyre-Walker YC,Rane RV,Reuter C,Vinti G,Rako L,Partridge L,Hoffmann AA (2013) Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster. Mol Ecol, 22(10), 2716 - 2725. 10.1111/mec.12301.
  2. Partridge L (2012) Diet and healthy aging New England Journal of Medicine, 367(26), 2550 - 2551.
  3. Papatheodorou I,Ziehm M,Wieser D,Alic N,Partridge L,Thornton JM (2012) Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing. PLoS One, 7(12), e50881. 10.1371/journal.pone.0050881.
  4. Slack C,Foley A,Partridge L (2012) Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila. PLoS One, 7(10), e47699. 10.1371/journal.pone.0047699.
  5. Rogers I,Kerr F,Martinez P,Hardy J,Lovestone S,Partridge L (2012) Ageing increases vulnerability to aβ42 toxicity in Drosophila. PLoS One, 7(7), e40569. 10.1371/journal.pone.0040569.
  6. Selman C,Partridge L (2012) A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice CELL CYCLE, 11(1), 17 - 18. 10.4161/cc.11.1.18736.
  7. Alic N,Hoddinott MP,Foley A,Slack C,Piper MD,Partridge L (2012) Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies. PLoS One, 7(9), e45367. 10.1371/journal.pone.0045367.
  8. Cochemé HM,Logan A,Prime TA,Abakumova I,Quin C,McQuaker SJ,Patel JV,Fearnley IM,James AM,Porteous CM,Smith RA,Hartley RC,Partridge L,Murphy MP (2012) Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila. Nat Protoc, 7(5), 946 - 958. 10.1038/nprot.2012.035.
  9. Chen Y,Lee SF,Blanc E,Reuter C,Wertheim B,Martinez-Diaz P,Hoffmann AA,Partridge L (2012) Genome-wide transcription analysis of clinal genetic variation in Drosophila. PLoS One, 7(4), e34620. 10.1371/journal.pone.0034620.
  10. Gioti A,Wigby S,Wertheim B,Schuster E,Martinez P,Pennington CJ,Partridge L,Chapman T (2012) Sex peptide of Drosophila melanogaster males is a global regulator of reproductive processes in females Proceedings of the Royal Society B: Biological Sciences. 10.1098/rspb.2012.1634.
  11. Augustin H,Allen MJ,Partridge L (2011) Electrophysiological recordings from the giant fiber pathway of D. melanogaster. Journal of visualized experiments : JoVE(47).
  12. Kerr F,Augustin H,Piper MD,Gandy C,Allen MJ,Lovestone S,Partridge L (2011) Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease. Neurobiol Aging, 32(11), 1977 - 1989. 10.1016/j.neurobiolaging.2009.10.015.
  13. Augustin H,Allen MJ,Partridge L (2011) Electrophysiological recordings from the giant fiber pathway of D. melanogaster Journal of Visualized Experiments(47).
  14. Slack C,Giannakou ME,Foley A,Goss M,Partridge L (2011) dFOXO-independent effects of reduced insulin-like signaling in Drosophila Aging Cell, 10(5), 735 - 748.
  15. Burnett C,Valentini S,Cabreiro F,Goss M,Somogyvári M,Piper MD,Hoddinott M,Sutphin GL,Leko V,McElwee JJ,Vazquez-Manrique RP,Orfila AM,Ackerman D,Au C,Vinti G,Riesen M,Howard K,Neri C,Bedalov A,Kaeberlein M,Soti C,Partridge L,Gems D (2011) Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature, 477(7365), 482 - 485. 10.1038/nature10296.
  16. Piper MD,Partridge L,Raubenheimer D,Simpson SJ (2011) Dietary restriction and aging: a unifying perspective. Cell Metab, 14(2), 154 - 160. 10.1016/j.cmet.2011.06.013.
  17. Lee SF,Chen Y,Varan AK,Wee CW,Rako L,Axford JK,Good RT,Blacket MJ,Reuter C,Partridge L,Hoffmann AA (2011) Molecular Basis of Adaptive Shift in Body Size in Drosophila melanogaster: Functional and Sequence Analyses of the Dca Gene MOL BIOL EVOL, 28(8), 2393 - 2402. 10.1093/molbev/msr064.
  18. Alic N,Andrews TD,Giannakou ME,Papatheodorou I,Slack C,Hoddinott MP,Cocheme HM,Schuster EF,Thornton JM,Partridge L (2011) Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling Mol Syst Biol, 7. 10.1038/msb.2011.36.
  19. Bjedov I,Partridge L (2011) A longer and healthier life with TOR down-regulation: genetics and drugs BIOCHEMICAL SOCIETY TRANSACTIONS, 39, 460 - 465. 10.1042/BST0390460.
  20. Slack C,Giannakou ME,Foley A,Goss M,Partridge L (2011) dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell, 10(5), 735 - 748. 10.1111/j.1474-9726.2011.00707.x.
  21. Cochemé HM,Quin C,McQuaker SJ,Cabreiro F,Logan A,Prime TA,Abakumova I,Patel JV,Fearnley IM,James AM,Porteous CM,Smith RA,Saeed S,Carré JE,Singer M,Gems D,Hartley RC,Partridge L,Murphy MP (2011) Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab, 13(3), 340 - 350. 10.1016/j.cmet.2011.02.003.
  22. Selman C,Partridge L,Withers DJ (2011) Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1 PLOS ONE, 6(1). 10.1371/journal.pone.0016144.
  23. Partridge L (2011) Comments from the new Editor. Philos Trans R Soc Lond B Biol Sci, 366(1561), 5. 10.1098/rstb.2010.0314.
  24. Partridge L,Thornton J,Bates G (2011) The new science of ageing. Philos Trans R Soc Lond B Biol Sci, 366(1561), 6 - 8. 10.1098/rstb.2010.0298.
  25. Augustin H,Allen MJ,Partridge L (2011) Electrophysiological recordings from the giant fiber pathway of D. melanogaster. J Vis Exp(47). 10.3791/2412.
  26. Alic N,Hoddinott MP,Vinti G,Partridge L (2011) Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. Aging Cell, 10(1), 137 - 147. 10.1111/j.1474-9726.2010.00653.x.
  27. Partridge L (2011) Some highlights of research on aging with invertebrates, 2010. Aging Cell, 10(1), 5 - 9. 10.1111/j.1474-9726.2010.00649.x.
  28. Partridge L,Alic N,Bjedov I,Piper MD (2011) Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network. Exp Gerontol, 46(5), 376 - 381. 10.1016/j.exger.2010.09.003.
  29. Wigby S,Slack C,Grönke S,Martinez P,Calboli FC,Chapman T,Partridge L (2011) Insulin signalling regulates remating in female Drosophila. Proc Biol Sci, 278(1704), 424 - 431. 10.1098/rspb.2010.1390.
  30. Alic N,Partridge L (2011) Death and dessert: nutrient signalling pathways and ageing. Curr Opin Cell Biol, 23(6), 738 - 743. 10.1016/j.ceb.2011.07.006.
  31. Augustin H,Allen MJ,Partridge L (2010) Electrophysiological recordings from the giant fiber pathway of D. melanogaster Journal of Visualized Experiments(47).
  32. Fontana L,Partridge L,Longo VD (2010) Dietary Restriction: Theory Fails to Satiate Response SCIENCE, 329(5995), 1015 - 1015.
  33. Fontana L,Partridge L,Longo VD (2010) Extending Healthy Life Span-From Yeast to Humans SCIENCE, 328(5976), 321 - 326. 10.1126/science.1172539.
  34. Piper MD,Wong R,Grandison RC,Bass TM,Martinez PM,Partridge L (2010) Water-independent effects of dietary restriction in Drosophila. Proc Natl Acad Sci U S A, 107(14), E54 - E56. 10.1073/pnas.0914686107.
  35. Jacobson J,Lambert AJ,Portero-Otín M,Pamplona R,Magwere T,Miwa S,Driege Y,Brand MD,Partridge L (2010) Biomarkers of aging in Drosophila. Aging Cell, 9(4), 466 - 477. 10.1111/j.1474-9726.2010.00573.x.
  36. Broughton SJ,Slack C,Alic N,Metaxakis A,Bass TM,Driege Y,Partridge L (2010) DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition. Aging Cell, 9(3), 336 - 346. 10.1111/j.1474-9726.2010.00558.x.
  37. Fontana L,Partridge L (2010) Dietary Restriction: Standing Up for Sirtuins Response SCIENCE, 329(5995), 1013 - 1013.
  38. Partridge L (2010) The new biology of ageing. Philos Trans R Soc Lond B Biol Sci, 365(1537), 147 - 154. 10.1098/rstb.2009.0222.
  39. Bjedov I,Toivonen JM,Kerr F,Slack C,Jacobson J,Foley A,Partridge L (2010) Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab, 11(1), 35 - 46. 10.1016/j.cmet.2009.11.010.
  40. Slack C,Werz C,Wieser D,Alic N,Foley A,Stocker H,Withers DJ,Thornton JM,Hafen E,Partridge L (2010) Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. PLoS Genet, 6(3), e1000881. 10.1371/journal.pgen.1000881.
  41. Sofola O,Kerr F,Rogers I,Killick R,Augustin H,Gandy C,Allen MJ,Hardy J,Lovestone S,Partridge L (2010) Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease. PLoS Genet, 6(9). 10.1371/journal.pgen.1001087.
  42. PARTRIDGE L (2010) The new biology of ageing. Phil. Trans. B, 147 - 154.
  43. PARTRIDGE L (2010) The new biology of ageing. Phil. Trans. B, 147 - 154.
  44. Grönke S,Clarke DF,Broughton S,Andrews TD,Partridge L (2010) Molecular evolution and functional characterization of Drosophila insulin-like peptides. PLoS Genet, 6(2), e1000857. 10.1371/journal.pgen.1000857.
  45. Slaidina M,Delanoue R,Gronke S,Partridge L,Leopold P (2009) A Drosophila Insulin-like Peptide Promotes Growth during Nonfeeding States DEV CELL, 17(6), 874 - 884. 10.1016/j.devcel.2009.10.009.
  46. PARTRIDGE L,Gronke S (2009) The functions of Insulin-like peptides in Insects..
  47. Ikeya T,Broughton S,Alic N,Grandison R,Partridge L (2009) The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila. Proc Biol Sci, 276(1674), 3799 - 3807. 10.1098/rspb.2009.0778.
  48. Selman C,Tullet JM,Wieser D,Irvine E,Lingard SJ,Choudhury AI,Claret M,Al-Qassab H,Carmignac D,Ramadani F,Woods A,Robinson IC,Schuster E,Batterham RL,Kozma SC,Thomas G,Carling D,Okkenhaug K,Thornton JM,Partridge L,Gems D,Withers DJ (2009) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science, 326(5949), 140 - 144. 10.1126/science.1177221.
  49. Augustin H,Partridge L (2009) Invertebrate models of age-related muscle degeneration. Biochim Biophys Acta, 1790(10), 1084 - 1094. 10.1016/j.bbagen.2009.06.011.
  50. Partridge L (2009) Some highlights of research on aging with invertebrates, 2009. Aging Cell, 8(5), 509 - 513. 10.1111/j.1474-9726.2009.00498.x.

Qualifications

  • 1974: Doctor of Philosophy, University of Oxford
  • 1971: Bachelor of Arts, University of Oxford

Keywords

  • Ageing
  • Alzheimer's disease
  • Autophagy
  • Bioinformatic analysis
  • Bioinformatics
  • Brain
  • Cell culture
  • Dementia
  • Diabetes
  • Drosophila
  • Enzyme assays
  • Evolution
  • Fluorescence microscopy techniques
  • Gene expression
  • Gene expression profiling - tissue level
  • Genetic manipulation (including knockout/knockin)
  • Genetically encoded reporters/indicators
  • Genetics
  • Genomic analyses
  • Genomics
  • Light microscopic techniques
  • Linkage, mapping and positional cloning
  • MRI
  • Microarrays
  • Mitochondria
  • Modelling
  • Mouse
  • Neurodegeneration
  • Protein purification
  • Proteomics
  • Proteomics
  • Transgenic mice