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Dr Jenny Morgan

  • Telephone:

    0207 905 2874

  • Extension:

    42874

  • Email:

    jennifer.morgan@ucl.ac.uk

  • Address:

    Dubowitz Neuromuscular Centre, Institute of Child Health,
    UCL, 30 Guildford St,
    London,
    WC1N1EH

  • Appointments:

    Reader in Cell Biology, ICH - Dubowitz Neuromuscular Centre, Dept of Neurosciences & Mental Health
No image is available

Research Summary

The aim of my research programme is to understand the biology of skeletal muscle, with particular emphasis on identifying the cell types that contribute to muscle regeneration and how they may be manipulated to enhance muscle repair and regeneration.

Research Activities

  • Paediatric Neurology
  • Stem cells and skeletal muscle regeneration

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Calhabeu F,Hayashi S,Morgan JE,Relaix F,Zammit PS (2013) Alveolar rhabdomyosarcoma-associated proteins PAX3/FOXO1A and PAX7/FOXO1A suppress the transcriptional activity of MyoD-target genes in muscle stem cells ONCOGENE, 32(5), 651 - 662. 10.1038/onc.2012.73.
  2. Boldrin L,Morgan JE (2013) Grafting of a single donor myofibre promotes hypertrophy in dystrophic mouse muscle. PLoS One, 8(1), e54599. 10.1371/journal.pone.0054599.
  3. Briggs D,Morgan JE (2013) Recent progress in satellite cell/myoblast engraftment - relevance for therapy. FEBS J. 10.1111/febs.12273.
  4. Ross J,Benn A,Jonuschies J,Boldrin L,Muntoni F,Hewitt JE,Brown SC,Morgan JE (2012) Defects in glycosylation impair satellite stem cell function and niche composition in the muscles of the dystrophic largemyd mouse Stem Cells, 30(10), 2330 - 2341.
  5. Boldrin L,Neal A,Zammit PS,Muntoni F,Morgan JE (2012) Donor satellite cell engraftment is significantly augmented when the host niche is preserved and endogenous satellite cells are incapacitated. Stem Cells, 30(9), 1971 - 1984. 10.1002/stem.1158.
  6. Cirak S,Feng L,Anthony K,Arechavala-Gomeza V,Torelli S,Sewry C,Morgan JE,Muntoni F (2012) Restoration of the dystrophin-associated glycoprotein complex after exon skipping therapy in Duchenne muscular dystrophy. Mol Ther, 20(2), 462 - 467. 10.1038/mt.2011.248.
  7. Boldrin L,Morgan JE (2012) Labelling satellite cells on human muscle fibres NEUROMUSCULAR DISORDERS, 22, S15 - S15.
  8. Neal A,Boldrin L,Morgan JE (2012) The satellite cell in male and female, developing and adult mice: evidence for functionally distinct stem cell populations NEUROMUSCULAR DISORDERS, 22, S5 - S5.
  9. Neal A,Boldrin L,Morgan JE (2012) The satellite cell in male and female, developing and adult mouse muscle: distinct stem cells for growth and regeneration. PLoS One, 7(5), e37950. 10.1371/journal.pone.0037950.
  10. Ono Y,Calhabeu F,Morgan JE,Katagiri T,Amthor H,Zammit PS (2011) BMP signalling permits population expansion by preventing premature myogenic differentiation in muscle satellite cells CELL DEATH DIFFER, 18(2), 222 - 234. 10.1038/cdd.2010.95.
  11. Meng J,Muntoni F,Morgan JE (2011) Stem cells to treat muscular dystrophies - where are we? Neuromuscul Disord, 21(1), 4 - 12. 10.1016/j.nmd.2010.10.004.
  12. Muses S,Morgan JE,Wells DJ (2011) Restoration of dystrophin expression using the Sleeping Beauty transposon. PLoS Curr, 3, RRN1296. 10.1371/currents.RRN1296.
  13. Jonuschies J,Boldrin L,Thrasher A,Morgan JE,Muntoni F (2011) Assessment of potential promoters for lentiviral gene therapy in DMD HUM GENE THER, 22(10), A62 - A63.
  14. Jonuschies J,Boldrin L,Thrasher A,Morgan JE,Muntoni F (2011) Assessment of potential promoters for lentiviral gene therapy in DMD HUM GENE THER, 22(10), A5 - A5.
  15. Anthony K,Cirak S,Torelli S,Tasca G,Feng L,Arechavala-Gomeza V,Armaroli A,Guglieri M,Straathof CS,Verschuuren JJ,Aartsma-Rus A,Helderman-van den Enden P,Bushby K,Straub V,Sewry C,Ferlini A,Ricci E,Morgan JE,Muntoni F (2011) Dystrophin quantification and clinical correlations in Becker muscular dystrophy: implications for clinical trials. Brain, 134(Pt 12), 3547 - 3559. 10.1093/brain/awr291.
  16. Morgan JE (2011) Satellite cells and skeletal muscle regeneration NEUROMUSCULAR DISORDERS, 21(9-10), 640 - 640. 10.1016/j.nmd.2011.06.756.
  17. Muses S,Morgan JE,Wells DJ (2011) A New Extensively Characterised Conditionally Immortal Muscle Cell-Line for Investigating Therapeutic Strategies in Muscular Dystrophies PLOS ONE, 6(9). 10.1371/journal.pone.0024826.
  18. Cirak S,Arechavala-Gomeza V,Guglieri M,Feng L,Torelli S,Anthony K,Abbs S,Garralda ME,Bourke J,Wells DJ,Dickson G,Wood MJ,Wilton SD,Straub V,Kole R,Shrewsbury SB,Sewry C,Morgan JE,Bushby K,Muntoni F (2011) Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study. Lancet, 378(9791), 595 - 605. 10.1016/S0140-6736(11)60756-3.
  19. Neal A,Boldrin L,Morgan JE (2011) Age and sex related differences in satellite cell number, proliferation and self renewal NEUROMUSCULAR DISORDERS, 21, S12 - S12.
  20. Boldrin L,Zammit PS,Muntoni F,Morgan JE (2011) The host muscle environment has got a profound effect on satellite cell function NEUROMUSCULAR DISORDERS, 21, S12 - S12.
  21. Zaharieva I,Cirak S,Morgan JE,Muntoni F (2011) Identifying genomic pre-clinical biomarkers for diagnostics and therapeutics of Duchenne muscular dystrophy NEUROMUSCULAR DISORDERS, 21, S9 - S9.
  22. Reza M,Laval S,Morgan JE,Muntoni F,Bushby K,Straub V,Lochmuller H (2011) Optimal dystrophin mini-construct for gene delivery to skeletal muscle NEUROMUSCULAR DISORDERS, 21, S9 - S9.
  23. Kim J,Anthony K,Cloke V,Yau M,Abbs S,Morgan JE (2011) The feasibility of exon skipping to restore the reading frame in DMD patients with duplications NEUROMUSCULAR DISORDERS, 21, S8 - S9.
  24. Cirak S,Arechavala-Gomeza V,Guglieri M,Feng L,Torelli S,Anthony K,Garralda ME,Wells D,Dickson G,Wood MJA,Wilton SD,Straub V,Shrewsbury SB,Sewry C,Morgan JE,Bushby K,Muntoni F (2011) Exon skipping and dystrophin restoration in Duchenne muscular dystrophy patients after systemic phosphorodiamidate morpholino oligomer treatment NEUROMUSCULAR DISORDERS, 21, S7 - S8.
  25. Asfahani R,Meng J,Muntoni F,Morgan JE (2011) Human skeletal-muscle derived CD133+cells as a promising tool for cell therapy of Duchenne muscular dystrophy NEUROMUSCULAR DISORDERS, 21, S7 - S7.
  26. Anthony K,Morgan JE,Muntoni F (2011) Quantification of exon skipping in Duchenne muscular dystrophy by qRT-PCR NEUROMUSCULAR DISORDERS, 21, S7 - S7.
  27. Meng J,Adkin CF,Xu SW,Muntoni F,Morgan JE (2011) Contribution of human muscle-derived cells to skeletal muscle regeneration in dystrophic host mice. PLoS One, 6(3), e17454. 10.1371/journal.pone.0017454.
  28. Kinali M,Arechavala-Gomeza V,Cirak S,Glover A,Guglieri M,Feng L,Hollingsworth KG,Hunt D,Jungbluth H,Roper HP,Quinlivan RM,Gosalakkal JA,Jayawant S,Nadeau A,Hughes-Carre L,Manzur AY,Mercuri E,Morgan JE,Straub V,Bushby K,Sewry C,Rutherford M,Muntoni F (2011) Muscle histology vs MRI in Duchenne muscular dystrophy. Neurology, 76(4), 346 - 353. 10.1212/WNL.0b013e318208811f.
  29. Boldrin L,Morgan JE (2011) Human satellite cells: identification on human muscle fibres. PLoS Curr, 3, RRN1294. 10.1371/currents.RRN1294.
  30. Ono Y,Boldrin L,Knopp P,Morgan JE,Zammit PS (2010) Functional heterogeneity of muscle satellite cells in both somite-derived and branchiomeric muscles FASEB JOURNAL, 24.
  31. Arechavala-Gomeza V,Kinali M,Feng L,Brown SC,Sewry C,Morgan JE,Muntoni F (2010) Immunohistological intensity measurements as a tool to assess sarcolemma-associated protein expression. Neuropathol Appl Neurobiol, 36(4), 265 - 274. 10.1111/j.1365-2990.2009.01056.x.
  32. Cirak S,Feng L,Torelli S,Arechavala-Gomeza V,Kinali M,Shrewsbury S,Morgan JE,Sewry C,Muntoni F (2010) Induction of dystrophin in DMD patients by antisense oligonucleotide AVI-4658 restores the dystrophin glycoprotein complex NEUROMUSCULAR DISORDERS, 20(9-10), 643 - 643. 10.1016/j.nmd.2010.07.150.
  33. Morgan J,Rouche A,Bousero P,Houssaini A,Gross J,Fiszman MY,Alameddine HS (2010) MMP-9 overexpression improves myogenic cell migration and engraftment Muscle and Nerve, 42(4), 584 - 595.
  34. Johnson D,Reza M,Morgan JE,Barresi R,Lochmuller H,Muntoni F (2010) MRC NMD Biobank service: an overview NEUROMUSCULAR DISORDERS, 20, S30 - S30.
  35. Meng J,Beley C,Adkin C,Muntoni F,Garcia L,Morgan JE (2010) Dystrophin expression in DMD pericytes after infection with U7 lentivirus designed to skip dystrophin exon 51 NEUROMUSCULAR DISORDERS, 20, S15 - S15.
  36. Neal A,Boldrin L,Morgan JE (2010) Satellite cell heterogeneity NEUROMUSCULAR DISORDERS, 20, S15 - S15.
  37. Boldrin L,Collins C,Gnocchi V,Zammit P,Morgan JE (2010) Pax3/Pax7 transcriptional activity is in vivo required for muscle differentiation NEUROMUSCULAR DISORDERS, 20, S15 - S15.
  38. Briggs D,Boldrin L,Morgan JE (2010) Phenotypic separation of satellite stem cells using flow cytometry NEUROMUSCULAR DISORDERS, 20, S14 - S15.
  39. Malerba A,Sharp P,Graham I,Arechavala V,Foster K,Morgan JE,Muntoni F,Wells D,Dickson G (2010) Chronic long term administration of phosphorodiamidate morpholino oligomer profoundly ameliorates activity, muscle strength and phenotype in dystrophic mdx mice NEUROMUSCULAR DISORDERS, 20, S12 - S12.
  40. Cirak S,Feng L,Arechavala V,Torelli S,Ganeshaguru K,Kinali M,Shrewsbury S,Morgan JE,Sewry C,Muntoni F (2010) Induction of dystrophin in Duchenne muscular dystrophy patients by antisense oligonucleotide AVI-4658 restores the dystrophin-associated glycoprotein complex NEUROMUSCULAR DISORDERS, 20, S6 - S6.
  41. Jonuschies J,Boldrin L,Muntoni F,Morgan JE (2010) Lentivirus-mediated stem cell therapy for Duchenne muscular dystrophy NEUROMUSCULAR DISORDERS, 20, S6 - S6.
  42. Malerba A,Sharp P,Graham IR,Arechavala-Gomeza V,Foster K,Morgan JE,Muntoni F,Wells D,Dickson G (2010) Clinically Applicable Dosing Regimens of Phosphorodiamidate Morpholino Oligomer Profoundly Improve Behaviour, Activity, and Dystrophic phenotype in mdx mice HUMAN GENE THERAPY, 21(4), 508 - 508.
  43. Boldrin L,Muntoni F,Morgan JE (2010) Are human and mouse satellite cells really the same? J Histochem Cytochem, 58(11), 941 - 955. 10.1369/jhc.2010.956201.
  44. Arechavala-Gomeza V,Kinali M,Feng L,Guglieri M,Edge G,Main M,Hunt D,Lehovsky J,Straub V,Bushby K,Sewry CA,Morgan JE,Muntoni F (2010) Revertant fibres and dystrophin traces in Duchenne muscular dystrophy: implication for clinical trials. Neuromuscul Disord, 20(5), 295 - 301. 10.1016/j.nmd.2010.03.007.
  45. Morgan JE,Zammit PS (2010) Direct effects of the pathogenic mutation on satellite cell function in muscular dystrophy. Exp Cell Res, 316(18), 3100 - 3108. 10.1016/j.yexcr.2010.05.014.
  46. Popplewell LJ,Adkin C,Arechavala-Gomeza V,Aartsma-Rus A,de Winter CL,Wilton SD,Morgan JE,Muntoni F,Graham IR,Dickson G (2010) Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials. Neuromuscul Disord, 20(2), 102 - 110. 10.1016/j.nmd.2009.10.013.
  47. Meng J,Adkin CF,Arechavala-Gomeza V,Boldrin L,Muntoni F,Morgan JE (2010) The contribution of human synovial stem cells to skeletal muscle regeneration. Neuromuscul Disord, 20(1), 6 - 15. 10.1016/j.nmd.2009.11.007.
  48. Boldrin L,Muntoni F,Morgan JE (2010) Are Human and Mouse Satellite Cells Really the Same? HEALTH TECHNOL ASSES, 14(42), 941 - 955. 10.1369/jhc.2010.956201.
  49. Collins CA,Gnocchi VF,White RB,Boldrin L,Perez-Ruiz A,Relaix F,Morgan JE,Zammit PS (2009) Integrated functions of Pax3 and Pax7 in the regulation of proliferation, cell size and myogenic differentiation PLoS ONE, 4(2), e4475.
  50. Ono Y,Boldrin L,Knopp P,Morgan JE,Zammit PS (2009) Muscle satellite cells are a functionally heterogeneous population in both somite-derived and branchiomeric muscles Dev.Biol..

Qualifications

  • 1986: Doctor of Philosophy, Charing Cross and Westminster Medical School
  • 1978: Bachelor of Science, King's College London