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Dr John Holton

  • Telephone:

    2076799485

  • Email:

    j.holton@ucl.ac.uk

  • Address:

    CIDIH,
    Windeyer Institute of Medical Sciences,
    London,
    W1T 4JF

  • Appointments:

    Honorary Senior Lecturer, Eastman Dental Institute, Faculty of Medical Sciences
No image is available

Research Summary

1 Inflammatory conditions of the gastrointestinal tract:- 1.1 Helicobacter pylori : Publications since 1983 on H. pylori, its epidemiology, pathogenesis, diagnosis and treatment. 1.2 Inflammatory bowel disease: Investigation of the role of the commensal flora to the development of IBD. 1.3 Clostridium difficile: Role of colonic ecology in the development of disease 2 Bionanotechnology : Development of POC tests for hospital pathogens using nanocantilevers; Use of gold/iron nanoparticles as therapeutics for antibiotic resistant micro-organisms 3 HAC: The environment as a source of HAI; validation of Health Service Guidance (Laundry)(95) 18 and the significance of C. difficile in contamination of laundry 4 Leprosy. Role of co-infections and proteoasome function in the development of TypeI and Type II reactions Current Research Helicobacter pylori. The development of novel anti-adhesins for H. pylori (and also rotavirus and Candida albicans), the role of Helicobacter in IBD and oral cancer in Sri Lanka and the effect of H. pylori on orexigenic hormone levels in Sri Lanka Microbial ecology of the colon and Inflammatory Bowel Disease The main emphasis for research has been the microbial ecology of the colon in inflammatory bowel disease, the development of a novel animal model of IBD by suppression of antiCD4 and the relationship of helminth infection in IBD in Sri Lanka Bio-Nanotechnology In collaboration with the London Centre for Nanotechnology the development of nano-cantlevers as point of case rapid diagnostics and in collaboration with Midatech development of the use of nanoparticles as therapeutic agents Hospital Acquired Infection and decontamination On behalf of the DoH work relating to re-validation of Health Service Guidance (Laundry) and the Uniform Working Party

Research Activities

  • Bionanotechnology
  • Hospital Acquired Infection
  • Inflammatory conditions of the gastrointestinal tract
  • Leprosy

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Donoghue HD,Holton J (2009) Intestinal tuberculosis Current Opinion in Infectious Diseases, 22(5), 490 - 496. 10.1097/QCO.0b013e3283306712.
  2. Hobsley M,Tovey FI,Holton J (2007) Helicobacter pylori and Gastric Cancer: neither friend nor foe Gastroenterology, 132, 2076 - 2076.
  3. Hobsley M,Tovey FI,Holton J (2007) How labile is gastric infection with H pylori? World Journal of Gastroenterology, 13(35), 4665 - 4668.
  4. Ricci C,Holton J,Vaira D (2007) Diaagnosis of helicobacter pylori: invasive and non-invasive tests. Best Practice and Research Clinical Gastroenterology, 21, 299 - 313.
  5. De Bernardis F,Liu H,O'Mahony R,La Valle R,Bartollino S,Sandini S,Grant S,Brewis N,Tomlinson I,Basset RC,Holton J,Roitt IM,Cassone A (2007) Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis The Journal of Infectious Diseases, 195, 149 - 157.
  6. Hobsley M,Tovey FI,Holton J (2006) Precise role of H pylori in duodenal ulceration World Journal of Gastroenterology, 12(40), 6413 - 6419.
  7. O'Mahony R,Basset C,Holton J,Vaira D,Roitt I (2005) Comparison of image analysis software packages in the assessment of adhesion of microorganisms to mucosal epithelium using confocal laser scanning microscopy Journal of Microbiological Methods, 61(1), 105 - 126.
  8. O'Mahony R,Al-Khtheeri H,Weeraskera D,Fernando N,Vaira D,Holton J,Basset C (2005) Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori World Journal of Gastroenterology, 11, 7499 - 7507.
  9. O'Mahony R,Vaira D,Holton J,Basset C (2004) Helicobacter pylori: current status and future prospects Science Progress, 87(4), 269 - 296.
  10. Basset C,Holton J,Gatta L,Ricci C,Bernabucci V,Liuzzi G,Vaira D (2004) Helicobacter pylori infection: anything new should we know? Alimentary Pharmacology and Therapeutics, 20(Supple), 31 - 41.
  11. Basset C,Holton J,Bazeos A,Vaira D,Bloom S (2004) Are Helicobacter species and enterotoxigenic Bacteroides fragilis involved in inflammatory bowel disease Digestive Diseases and Sciences, 49(9), 1425 - 1432.
  12. Fletcher HA,Donoghue HD,Holton J,Pap I,Spigelman M (2003) Widespread occurrence of Mycobacterium tuberculosis DNA from 18th-19th century Hungarians American Journal of Physical Anthropology, 120(2), 144 - 152. 10.1002/ajpa.10114.
  13. Vaira D,Vakil N,Gatta L,Ricci C,Menegatti M,Leandro G,Holton J,Russo VM,Miglioli M (2003) Effect of Helicobacter pylori eradication on development of dyspeptic and reflux disease in healthy asymptomatic subjects Gut, 52(11), 1543 - 1547.
  14. Basset C,Holton J,Ricci C,Gatta L,Tampieri A,Perna F,Miglioli M,Vaira D (2003) Diagnosis and treatment of Helicobacter: a 2002 updated review Alimentary Pharmacology and Therapeutics, 17(Suppl), 89 - 97.
  15. Perna F,Gatta L,Figura N,Ricci C,Tampieri A,Holton J,Miglioli M,Vaira D (2003) Susceptibility of Helicobacter pylori to metronidazole American Journal of Gastroenterology, 98(10), 2157 - 2161.
  16. Basset C,Holton J,O'Mahony R,Roitt I (2003) Innate immunity and pathogen-host interaction Vaccine, 21 Sup, S12 - S23.
  17. Shetty N,Holton J,Selkon JB (2003) Microbicidal and in-use activity of Sterilox: an effective and safe alternative to gluteraldehyde for use in endoscopy units Zentralsterilisation - Central Service, 11(3), 179 - 191.
  18. Gatta L,Perna F,Figura N,Ricci C,Holton J,D'Anna L,Miglioli M,Vaira D (2003) Antimicrobial activity of esomeprazole versus omeprazole against Helicobacter pylori Journal of Antimicrobial Chemotherapy, 51(2), 439 - 442.
  19. Fernando N,Holton J,Vaira D,DeSilva M,Fernando D (2002) Prevalence of Helicobacter pylori in Sri Lanka as determined by PCR Journal of Clinical Microbiology, 40(7), 2675 - 2676.
  20. Basset C,Holton J (2002) Inflammatory bowel disease: is the intestine a Trojan horse? Science Progress, 85(Pt 1), 33 - 56.
  21. Basset C,Bloom S,Holton J (2002) Lack of association between Helicobacter in the colonic environment and inflammatory bowel disease. [Abstract 13.10] Gut, 51(Supple), A79 - A79.
  22. Basset C,Holton J,Vaira D (2002) Helicobacter: a paradigm shift in peptic ulcer disease and more? Science Progress, 85(Pt 1), 13 - 31.
  23. Fernando N,Perera N,Holton J,Fernando D,de Silva M (2002) Prevalence of Helicobacter pylori in Sri Lanka: a study based on the polymerase chain reaction. [Abstract 6.25] Gut, 51(Supple), A36 - A37.
  24. Perna F,Gatta L,Figura N,Holton J,Osborn J,Ricci C,Tampieri A,Migliolo M,Vaira D (2002) Comparison of metronidazole susceptibility testing by agar dilution, disk diffussion and epsilometer test in Helicobacter pylori (Hp) isolates. [Abstract 1.26] Gut, 51(Supple), A7 - A7.
  25. Holton J,Basset C (2002) Novel strategies of mucosal immunisation through exploitations of mechanisms of innate immunity in pathogen-host interaction.
  26. Palli D,Menegatti M,Masala G,Ricci C,Saieva C,Holton J,Gatta L,Miglioli M,Vaira D (2002) Helicobacter pylori infection, anti-cagA antibodies and peptic ulcer: a case-control study in Italy Alimentary Pharmacology and Therapeutics - Supplement, 16(5), 1015 - 1020.
  27. Holton J (2002) Secrets of the Pharoahs: Tut's Family Curse.
  28. Fernando N,Holton J,Zulu I,Vaira D,Mwaba P,Kelly P (2001) Helicobacter pylori infection in an urban African population Journal of Clinical Microbiology, 39(4), 1323 - 1327.
  29. Holton J,Vaira D (2001) Gastric Helicobacters, 605 - 634.
  30. Fernando N,Perera N,Vaira D,Holton J (2001) Helicobacter pylori in school children from the Western province of Sri Lanka HELICOBACTER, 6(2), 169 - 174.
  31. Vaira D,Holton J,Ricci C,Menegatti M,Gatta L,Berardi S,Tampieri A,Miglioli M (2001) Review article: the transmission of Helicobacter pylori from stomach to stomach Alimentary Pharmacology and Therapeutics - Supplement, 15(Suppl), 33 - 42.
  32. Donoghue HD,Holton J,Spigelman M (2001) PCR primers that can detect low levels of Mycobacterium leprae DNA Journal of Medical Microbiology, 50(2), 177 - 182.
  33. Reinhard J,Basset C,Holton J,Binks M,Youinou P,Vaira D (2000) Image analysis method to assess adhesion of Helicobacter pylori to gastric epithelium using confocal laser scanning microscopy Journal of Microbiological Methods, 39(3), 179 - 187.
  34. Menegatti M,Figura N,Farinelli F,Landi F,Acciardi C,Ricci C,Holton J,Gatta L,Crosatti M,Polacci R,Miglioli M,Vaira D (2000) Helicobacter pylori seroconversion in asymptomatic blood donors: a five-year follow-up Digestive Diseases and Sciences, 45(8), 1653 - 1659.
  35. Shetty N,Srinivasan S,Holton J,Ridgway GL (2000) Evaluation of microbicidal activity of a new disinfectant: Sterilox 2500 against Clostridium difficile spores, Helicobacter pylori, vancomycin resistant Enterococcus species, Candida albicans and several Mycobacterium species Journal of Hospital Infection, 41(2), 101 - 105.
  36. Loh W,Ng VV,Holton J (2000) Bacterial flora on the white coats of medical students Journal of Hospital Infection, 45(1), 65 - 68.
  37. Checci L,Felice P,Acciardi C,Ricci C,Gatta L,Polacci R,Holton J,Vaira D (2000) Absence of Helicobacter pylori in dental plaque assessed by stool test American Journal of Gastroenterology, 95(10), 3005 - 3006.
  38. Vaira D,Holton J,Menegatti M,Ricci C,Gatta L,Geminiani A,Miglioli M (2000) Review article: Invasive and non-invasive tests for Helicobacter pylori infection Alimentary Pharmacology and Therapeutics, 14(Supple), 13 - 22.
  39. Lydyard PM,Lakhani SR,Dogan A,Holton JM,Patterson KG,Bolodeoku J,Playfair JHL (2000) Pathology Integrated: An A-Z of Disease and Its Pathogenesis.
  40. Ali A,Menegatti M,Gatta L,Landi F,Ricci C,Acciardi C,Miglioli M,Vaira D,Holton J (1999) A second-line anti-Helicobacter pylori therapy in patients with previously failed treatment American Journal of Gastroenterology, 94(8), 2321 - 2323. 10.1016/S0002-9270(99)00389-5.
  41. Fusconi M,Vaira D,Menegatti M,Farinelli S,Figura N,Holton J,Ricci C,Corinaldesi R,Miglioli M (1999) Anti-CagA reactivity in Helicobacter pylori-negative subjects: a comparison of three different methods Digestive Diseases and Sciences, 44(8), 1691 - 1695.
  42. Vaira D,Holton J,Menegatti M,Ricci C,Landi F,Ali' A,Gatta L,Acciardi C,Farinelli S,Crosatti M,Berardi S,Miglioli M (1999) New immunological assays for the diagnosis of Helicobacter pylori infection Gut, 45(Suppl 1), I23 - I27.
  43. Shetty N,Srinivasan S,Holton J,Ridgway GL (1999) Evaluation of microbicidal activity of a new disinfectant: Sterilox 2500 against Clostridium difficile spores, Helicobacter pylori, vancomycin resistant Enterococcus species, Candida albicans and several Mycobacterium species Journal of Hospital Infection, 41(2), 101 - 105.
  44. Cacciari E,Menegatti M,Salardi S,Ali A,Stella FA,Figura N,Landi F,Holton J,Farinelli S,Cuccaro V,Miglioli M,Vaira D (1999) Helicobacter pylori infection and cytotoxic antigen associated gene "A" status in short children Journal of Pediatric Endocrinology and Metabolism, 12(2), 197 - 201.
  45. Vaira D,Holton J,Menegatti M,Gatta L,Ricci C,Ali A,Landi F,Moretti C,Miglioli M (1998) Routes of transmission of Helicobacter pylori infection Italian Journal of Gastroenterology and Hepatology, 30(Suppl 3), S279 - S285.
  46. Vaira D,Holton J (1998) Vector potential of houseflies (Musca domestica) for Helicobacter pylori Helicobacter, 3(1), 65 - 66. 10.1046/j.1523-5378.1998.08033.x.
  47. Menegatti M,Holton J,Figura N,Biasco G,Ricci C,Oderda G,Conte R,Miglioli M,Vaira D (1998) Clinical significance of Helicobacter pylori seropositivity and seronegativity in asymptomatic blood donors Digestive Diseases and Sciences, 43(11), 2542 - 2548.
  48. Vaira D,Menegatti M,Salardi S,Ali A,Altomare Stella F,Figura N,Landi F,Holton J,Farinelli S,Cuccaro V,Miglioli M,Cacciari E (1998) Helicobacter pylori and diminished growth in children: is it simply a marker of deprivation? Italian Journal of Gastroenterology and Hepatology, 30(1), 129 - 133.
  49. Oshowo A,Tunio M,Gillam D,Botha AJ,Holton J,Boulos P,Hobsley M (1998) Oral colonization is unlikely to play an important role in Helicobacter pylori infection British Journal of Surgery, 85(6), 850 - 852.
  50. Vaira D,Holton J,Menegatti M,Landi F,Ricci C,Ali A,Gatta L,Farinelli S,Acciardi C,Massardi B,Miglioli M (1998) Blood tests in the management of Helicobacter pylori infection. Italian Helicobacter pylori Study Group Gut, 43(Suppl 1), S39 - S46.

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Keywords

  • Antibody assays
  • Bionanotechnology
  • Confocal microscopy
  • ELISA
  • Electrophoresis techniques
  • Fluorescence microscopy techniques
  • Helicobacter pylori
  • Infection
  • Inflammation