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Dr Jason Warren

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Research Summary

Jason Warren is a Wellcome Trust Senior Clinical Fellow and Honorary Consultant Neurologist. His research is directed toward the systems neuroscience of neurodegenerative disease, using complex sound (including environmental sounds, voices, speech and music) as a paradigm to understand the mechanisms and brain basis for impaired information processing in the dementias. This work employs a range of techniques including psychophysics, neuropsychology, structural and functional MRI. Dr Warren has broad clinical interests in the wider field of cognitive and behavioural neurology.

Research Activities

  • Auditory information processing in dementia
  • Changes in pattern of Stuttering between Childhood
  • Protein biomarker

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Clark CN,Warren JD (2013) A Hypnic Hypothesis of Alzheimer's Disease. Neurodegener Dis. 10.1159/000350060.
  2. Lashley T,Rohrer JD,Mahoney CJ,Polke JM,Ryan NS,Isaacs A,Mead S,Warren JD,Revesz T (2013) Clinical and pathological features of frontotemporal dementia linked to C9ORF72 homozygosity NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 39, 30 - 31.
  3. Yong KX,Warren JD,Warrington EK,Crutch SJ (2013) Intact reading in patients with profound early visual dysfunction. Cortex. 10.1016/j.cortex.2013.01.009.
  4. Mahoney CJ,Downey LE,Beck J,Liang Y,Mead S,Perry RJ,Warren JD (2013) The Presenilin 1 P264L Mutation Presenting as non-Fluent/Agrammatic Primary Progressive Aphasia. J Alzheimers Dis. 10.3233/JAD-122092.
  5. Crutch SJ,Lehmann M,Warren JD,Rohrer JD (2013) The language profile of posterior cortical atrophy. J Neurol Neurosurg Psychiatry, 84(4), 460 - 466. 10.1136/jnnp-2012-303309.
  6. Beck J,Poulter M,Hensman D,Rohrer JD,Mahoney CJ,Adamson G,Campbell T,Uphill J,Borg A,Fratta P,Orrell RW,Malaspina A,Rowe J,Brown J,Hodges J,Sidle K,Polke JM,Houlden H,Schott JM,Fox NC,Rossor MN,Tabrizi SJ,Isaacs AM,Hardy J,Warren JD,Collinge J,Mead S (2013) Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population. Am J Hum Genet, 92(3), 345 - 353. 10.1016/j.ajhg.2013.01.011.
  7. Rohrer JD,Caso F,Mahoney C,Henry M,Rosen HJ,Rabinovici G,Rossor MN,Miller B,Warren JD,Fox NC,Ridgway GR,Gorno-Tempini ML (2013) Patterns of longitudinal brain atrophy in the logopenic variant of primary progressive aphasia. Brain Lang. 10.1016/j.bandl.2012.12.008.
  8. Mahoney CJ,Malone IB,Ridgway GR,Buckley AH,Downey LE,Golden HL,Ryan NS,Ourselin S,Schott JM,Rossor MN,Fox NC,Warren JD (2013) White matter tract signatures of the progressive aphasias. Neurobiol Aging, 34(6), 1687 - 1699. 10.1016/j.neurobiolaging.2012.12.002.
  9. Omar R,Mahoney CJ,Buckley AH,Warren JD (2013) Flavour identification in frontotemporal lobar degeneration. J Neurol Neurosurg Psychiatry, 84(1), 88 - 93. 10.1136/jnnp-2012-303853.
  10. Witoonpanich P,Cash DM,Shakespeare TJ,Yong KX,Nicholas JM,Omar R,Crutch SJ,Rossor MN,Warren JD (2013) Olfactory impairment in posterior cortical atrophy. J Neurol Neurosurg Psychiatry, 84(5), 588 - 590. 10.1136/jnnp-2012-304497.
  11. Downey LE,Mahoney CJ,Rossor MN,Crutch SJ,Warren JD (2012) Impaired self-other differentiation in frontotemporal dementia due to the C9ORF72 expansion Alzheimer's Research and Therapy, 4(5).
  12. Rohrer JD,Rossor MN,Warren JD (2012) Alzheimer's pathology in primary progressive aphasia. Neurobiol Aging, 33(4), 744 - 752. 10.1016/j.neurobiolaging.2010.05.020.
  13. Warren JD,Fletcher PD,Golden HL (2012) The paradox of syndromic diversity in Alzheimer disease. Nat Rev Neurol, 8(8), 451 - 464. 10.1038/nrneurol.2012.135.
  14. Ridgway GR,Lehmann M,Barnes J,Rohrer JD,Warren JD,Crutch SJ,Fox NC (2012) Early-onset Alzheimer disease clinical variants: multivariate analyses of cortical thickness. Neurology, 79(1), 80 - 84. 10.1212/WNL.0b013e31825dce28.
  15. Novak MJ,Warren JD,Henley SM,Draganski B,Frackowiak RS,Tabrizi SJ (2012) Altered brain mechanisms of emotion processing in pre-manifest Huntington's disease. Brain, 135(Pt 4), 1165 - 1179. 10.1093/brain/aws024.
  16. Warren JD,Rohrer JD,Hardy J (2012) Disintegrating brain networks: from syndromes to molecular nexopathies. Neuron, 73(6), 1060 - 1062. 10.1016/j.neuron.2012.03.006.
  17. Rohrer JD,Clarkson MJ,Kittus R,Rossor MN,Ourselin S,Warren JD,Fox NC (2012) Rates of hemispheric and lobar atrophy in the language variants of frontotemporal lobar degeneration. J Alzheimers Dis, 30(2), 407 - 411. 10.3233/JAD-2012-111556.
  18. Mahoney C,Rossor MN,Fox NC,Warren JD (2012) PROFILES OF WHITE MATTER DEGENERATION IN FRONTOTEMPORAL DEMENTIA JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 83(3). 10.1136/jnnp-2011-301993.61.
  19. Sorbi S,Hort J,Erkinjuntti T,Fladby T,Gainotti G,Gurvit H,Nacmias B,Pasquier F,Popescu BO,Rektorova I,Religa D,Rusina R,Rossor M,Schmidt R,Stefanova E,Warren JD,Scheltens P (2012) EFNS-ENS Guidelines on the diagnosis and management of disorders associated with dementia European Journal of Neurology, 19(9), 1159 - 1179.
  20. Mahoney CJ,Beck J,Rohrer JD,Lashley T,Mok K,Shakespeare T,Yeatman T,Warrington EK,Schott JM,Fox NC,Rossor MN,Hardy J,Collinge J,Revesz T,Mead S,Warren JD (2012) Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features. Brain, 135(Pt 3), 736 - 750. 10.1093/brain/awr361.
  21. Goll JC,Kim LG,Ridgway GR,Hailstone JC,Lehmann M,Buckley AH,Crutch SJ,Warren JD (2012) Impairments of auditory scene analysis in Alzheimer's disease. Brain, 135(Pt 1), 190 - 200. 10.1093/brain/awr260.
  22. Mahoney C,Downey L,Ridgway G,Beck J,Clegg S,Blair M,Finnegan S,Leung K,Yeatman T,Golden H,Mead S,Rohrer J,Fox N,Warren J (2012) Longitudinal neuroimaging and neuropsychological profiles of frontotemporal dementia with C9ORF72 expansions Alzheimer's Research & Therapy, 4(5), 41. 10.1186/alzrt144.
  23. Downey LE,Blezat A,Nicholas J,Omar R,Golden HL,Mahoney CJ,Crutch SJ,Warren JD (2012) Mentalising music in frontotemporal dementia Cortex.
  24. Goll JC,Ridgway GR,Crutch SJ,Theunissen FE,Warren JD (2012) Nonverbal sound processing in semantic dementia: a functional MRI study. Neuroimage, 61(1), 170 - 180. 10.1016/j.neuroimage.2012.02.045.
  25. Omar R,Hailstone JC,Warren JD (2012) Semantic memory for music in dementia Music Perception, 29(5), 467 - 477.
  26. Kara E,Ling H,Pittman AM,Shaw K,de Silva R,Simone R,Holton JL,Warren JD,Rohrer JD,Xiromerisiou G,Lees A,Hardy J,Houlden H,Revesz T (2012) The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features Neurobiology of Aging.
  27. Henley SM,Novak MJ,Frost C,King J,Tabrizi SJ,Warren JD (2012) Emotion recognition in Huntington's disease: a systematic review. Neurosci Biobehav Rev, 36(1), 237 - 253. 10.1016/j.neubiorev.2011.06.002.
  28. Rohrer JD,Sauter D,Scott S,Rossor MN,Warren JD (2012) Receptive prosody in nonfluent primary progressive aphasias. Cortex, 48(3), 308 - 316. 10.1016/j.cortex.2010.09.004.
  29. Schott JM,Warren JD (2012) Alzheimer's disease: mimics and chameleons. Pract Neurol, 12(6), 358 - 366. 10.1136/practneurol-2012-000315.
  30. Rohrer JD,Warren JD (2011) Phenotypic signatures of genetic frontotemporal dementia. Curr Opin Neurol, 24(6), 542 - 549. 10.1097/WCO.0b013e32834cd442.
  31. Omar R,Rohrer JD,Hailstone JC,Warren JD (2011) Structural neuroanatomy of face processing in frontotemporal lobar degeneration. J Neurol Neurosurg Psychiatry, 82(12), 1341 - 1343. 10.1136/jnnp.2010.227983.
  32. Mahoney CJ,Buckley AH,Fox NC,Warren JD (2011) EVALUATING BEHAVIOUR OF SELF AND OTHERS IN FRONTOTEMPORAL LOBAR DEGENERATION J NEUROL NEUROSUR PS, 82(9). 10.1136/jnnp-2011-300645.3.
  33. Rascovsky K,Hodges JR,Knopman D,Mendez MF,Kramer JH,Neuhaus J,van Swieten JC,Seelaar H,Dopper EGP,Onyike CU,Hillis AE,Josephs KA,Boeve BF,Kertesz A,Seeley WW,Rankin KP,Johnson JK,Gorno-Tempini ML,Rosen H,Prioleau-Latham CE,Lee A,Kipps CM,Lillo P,Piguet O,Rohrer JD,Rossor MN,Warren JD,Fox NC,Galasko D,Salmon DP,Black SE,Mesulam M,Weintraub S,Dickerson BC,Diehl-Schmid J,Pasquier F,Deramecourt V,Lebert F,Pijnenburg Y,Chow TW,Manes F,Grafman J,Cappa SF,Freedman M,Grossman M,Miller BL (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia BRAIN, 134, 2456 - 2477. 10.1093/brain/awr179.
  34. Hailstone JC,Ridgway GR,Bartlett JW,Goll JC,Buckley AH,Crutch SJ,Warren JD (2011) Voice processing in dementia: a neuropsychological and neuroanatomical analysis. Brain, 134(Pt 9), 2535 - 2547. 10.1093/brain/awr205.
  35. Warren JD,Hailstone JC,Omar R (2011) Music and semantic dementia. Arch Neurol, 68(8), 1089. 10.1001/archneurol.2011.195.
  36. Ridgway GR,Lehmann M,Rohrer J,Clarkson M,Warren J,Ourselin S,Fox N (2011) Balanced sensitivity and specificity on unbalanced data using support vector machine re-thresholding.
  37. Lashley T,Rohrer JD,Bandopadhyay R,Fry C,Ahmed Z,Isaacs AM,Brelstaff JH,Borroni B,Warren JD,Troakes C,King A,Al-Saraj S,Newcombe J,Quinn N,Ostergaard K,Schrøder HD,Bojsen-Møller M,Braendgaard H,Fox NC,Rossor MN,Lees AJ,Holton JL,Revesz T (2011) A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies. Brain, 134(Pt 9), 2548 - 2564. 10.1093/brain/awr160.
  38. Fletcher PD,Warren JD (2011) Semantic dementia: a specific network-opathy. J Mol Neurosci, 45(3), 629 - 636. 10.1007/s12031-011-9586-3.
  39. Goll JC,Kim LG,Hailstone JC,Lehmann M,Buckley A,Crutch SJ,Warren JD (2011) Auditory object cognition in dementia. Neuropsychologia, 49(9), 2755 - 2765. 10.1016/j.neuropsychologia.2011.06.004.
  40. Mahoney CJ,Rohrer JD,Goll JC,Fox NC,Rossor MN,Warren JD (2011) Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia. J Neurol Neurosurg Psychiatry, 82(11), 1274 - 1278. 10.1136/jnnp.2010.235473.
  41. Rohrer JD,Warren JD,Reiman D,Uphill J,Beck J,Collinge J,Rossor MN,Isaacs AM,Mead S (2011) A novel exon 2 I27V VCP variant is associated with dissimilar clinical syndromes. J Neurol, 258(8), 1494 - 1496. 10.1007/s00415-011-5966-4.
  42. Mahoney CJ,Rohrer JD,Omar R,Rossor MN,Warren JD (2011) Neuroanatomical profiles of personality change in frontotemporal lobar degeneration. Br J Psychiatry, 198(5), 365 - 372. 10.1192/bjp.bp.110.082677.
  43. Omar R,Henley SM,Bartlett JW,Hailstone JC,Gordon E,Sauter DA,Frost C,Scott SK,Warren JD (2011) The structural neuroanatomy of music emotion recognition: evidence from frontotemporal lobar degeneration. Neuroimage, 56(3), 1814 - 1821. 10.1016/j.neuroimage.2011.03.002.
  44. Revesz T,Schott JM,Reiniger L,Thom M,Holton JL,Grieve J,Brandner S,Warren JD (2011) Brain biopsy in dementia: clinical indications and neuropathological diagnostic approach NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 37, 10 - 10.
  45. Rohrer JD,Lashley T,Schott JM,Warren JE,Mead S,Isaacs AM,Beck J,Hardy J,de Silva R,Warrington E,Troakes C,Al-Sarraj S,King A,Borroni B,Clarkson M,Ourselin S,Holton J,Fox NC,Revesz T,Rossor MN,Warren JD (2011) Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration Brain, 134(9), 2565 - 2581.
  46. Lehmann M,Rohrer JD,Clarkson MJ,Ridgway GR,Scahill RI,Modat M,Warren JD,Ourselin S,Barnes J,Rossor MN,Fox NC (2011) Patterns of cortical thickness in pathologically-confirmed typical and atypical Alzheimer's disease, 2, 57 - 67.
  47. Schott JM,Warren JD,Barkhof F,Rossor MN,Fox NC (2011) Suspected early dementia. BMJ, 343, d5568.
  48. Schott JM,Warren JD,Barkhof F,Rossor MN,Fox NC (2011) RATIONAL IMAGING Suspected early dementia BRIT MED J, 343. 10.1136/bmj.d5568.
  49. Goll JC,Crutch SJ,Warren JD (2010) Central auditory disorders: toward a neuropsychology of auditory objects. Curr Opin Neurol, 23(6), 617 - 627. 10.1097/WCO.0b013e32834027f6.
  50. Hailstone JC,Crutch SJ,Vestergaard MD,Patterson RD,Warren JD (2010) Progressive associative phonagnosia: a neuropsychological analysis. Neuropsychologia, 48(4), 1104 - 1114. 10.1016/j.neuropsychologia.2009.12.011.

Qualifications

  • 2005: Doctor of Philosophy, University of Newcastle upon Tyne
  • 1993: Bachelor of Medicine/Bachelor of Surgery, University of Adelaide
  • 1990: Bachelor of Medical Science, University of Adelaide

Keywords

  • Ageing
  • Alzheimer's disease
  • Aphasia
  • Auditory processing
  • Auditory system disorders
  • Auditory system in dementia, behavioural neurology
  • Cognition
  • Dementia
  • Dementia - Lewy Body
  • Dementia - frontotemporal
  • Dementia - subcortical
  • Dementia - vascular
  • Functional MRI (fMRI)
  • Huntington's disease
  • Magnetic resonance imaging (MRI)
  • Neurodegenerative diseases
  • Neuroimaging
  • Neuropsychological testing
  • Prion diseases
  • complex sound processing
  • fMRI