Recent Publications

Displaying 39 most recent publications. For the full list please visit UCL Discovery

1. Ackland GL,Kazymov V,Marina N,Singer M,Gourine AV (2013) Peripheral Neural Detection of Danger-Associated and Pathogen-Associated Molecular Patterns. Crit Care Med. 10.1097/CCM.0b013e31827c0b05.
2. Basalay M,Barsukevich V,Mastitskaya S,Mrochek A,Pernow J,Sjöquist PO,Ackland GL,Gourine AV,Gourine A (2012) Remote ischaemic pre- and delayed postconditioning - similar degree of cardioprotection but distinct mechanisms. Exp Physiol, 97(8), 908 - 917. 10.1113/expphysiol.2012.064923.
3. Mastitskaya S,Marina N,Gourine A,Gilbey MP,Spyer KM,Teschemacher AG,Kasparov S,Trapp S,Ackland GL,Gourine AV (2012) Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurones. Cardiovasc Res, 95(4), 487 - 494. 10.1093/cvr/cvs212.
4. Pearse RM,Ackland GL (2012) Perioperative fluid therapy Intravenous fluid therapy is an important aspect of perioperative care, but doctors often prescribe fluid with limited knowledge of its benefits and risks. This article provides an evidence based summary of current best practice in the prescription of fluid for patients undergoing major non-cardiac surgery. BRITISH MEDICAL JOURNAL, 344. 10.1136/bmj.e2865.
5. Holm L,Ackland GL,Edwards MR,Breckenridge RA,Sim RB,Offer J (2012) Chemical labelling of active serum thioester proteins for quantification. Immunobiology, 217(2), 256 - 264. 10.1016/j.imbio.2011.07.021.
6. Dyson A,Cone S,Singer M,Ackland GL (2012) Microvascular and macrovascular flow are uncoupled in early polymicrobial sepsis. Br J Anaesth, 108(6), 973 - 978. 10.1093/bja/aes093.
7. Sultan P,Hamilton MA,Ackland GL (2012) Preoperative muscle weakness as defined by handgrip strength and postoperative outcomes: a systematic review. BMC Anesthesiol, 12, 1. 10.1186/1471-2253-12-1.
8. Pearse RM,Ackland GL (2012) [Perioperative fluid therapy]. Praxis (Bern 1994), 101(17), 1113 - 1118. 10.1024/1661-8157/a001028.
9. Ackland GL (2012) Chronic Kidney Disease and Postoperative Morbidity Associated with Renal Dysfunction After Elective Orthopedic Surgery Response ANESTHESIA AND ANALGESIA, 114(3), 700 - 700. 10.1213/ANE.0b013e318245dd26.
10. Pearse RM,Ackland GL (2012) Perioperative fluid therapy. BMJ, 344, e2865.
11. Ackland GL,Moran N,Cone S,Grocott MP,Mythen MG (2011) Chronic kidney disease and postoperative morbidity after elective orthopedic surgery. Anesth Analg, 112(6), 1375 - 1381. 10.1213/ANE.0b013e3181ee8456.
12. Ackland GL (2011) Reply from the authors. Br J Anaesth, 106(5), 751. 10.1093/bja/aer070.
13. Edwards M,Whittle J,Ackland GL (2011) Biomarkers to guide perioperative management. Postgrad Med J, 87(1030), 542 - 549. 10.1136/pgmj.2010.107177.
14. Ackland GL,Edwards M (2010) Defining higher-risk surgery. Curr Opin Crit Care, 16(4), 339 - 346. 10.1097/MCC.0b013e328339fad5.
15. Ackland GL,Yao ST,Rudiger A,Dyson A,Stidwill R,Poputnikov D,Singer M,Gourine AV (2010) Cardioprotection, attenuated systemic inflammation, and survival benefit of beta1-adrenoceptor blockade in severe sepsis in rats. Crit Care Med, 38(2), 388 - 394. 10.1097/CCM.0b013e3181c03dfa.
16. Ackland GL,Del Arroyo AG,Yao ST,Stephens RC,Dyson A,Klein NJ,Singer M,Gourine AV (2010) Low molecular weight polyethylene glycol improves survival in experimental sepsis. Critical Care Medicine, 38, 629 - 636.
17. Barnes SJ,Singer M,Ackland GL (2010) DOBUTAMINE STRESS ECHOCARDIOGRAPHY UNMASKS MYOCARDIAL DYSFUNCTION IN EARLY RODENT POLYMICROBIAL SEPSIS INTENSIVE CARE MEDICINE, 36, S334 - S334.
18. Ackland GL,Dyson A,Singer M (2010) Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest. JAMA, 304(13), 1440. 10.1001/jama.2010.1396.
19. Ackland GL,Harris S,Ziabari Y,Grocott M,Mythen M,SOuRCe Investigators (2010) Revised cardiac risk index and postoperative morbidity after elective orthopaedic surgery: a prospective cohort study. Br J Anaesth, 105(6), 744 - 752. 10.1093/bja/aeq245.
20. del Arroyo AG,Singer M,Ackland GL (2010) NEURO-IMMUNOMODULATION OF HUMAN CD14+CD16+NEUTROPHILS IN SEPSIS INTENSIVE CARE MEDICINE, 36, S409 - S409.
21. Barnes SJ,Ackland GL (2010) Beta-adrenoreceptor modulation of metabolic, endocrine and immunologic function during critical illness. Endocr Metab Immune Disord Drug Targets, 10(3), 292 - 300.
22. Ackland GL,O'Beirne J,Platts AR,Ward SC (2008) False-positive presentation of Battle's sign during hepatic encephalopathy. Neurocrit Care, 9(2), 253 - 255. 10.1007/s12028-008-9116-5.
23. Ackland GL,Harrington J,Downie P,Holding JW,Singh-Ranger D,Griva K,Mythen MG,Newman SP (2008) Dehydration induced by bowel preparation in older adults does not result in cognitive dysfunction. Anesth Analg, 106(3), 924 - 929. 10.1213/ane.0b013e3181615247.
24. Ackland GL,Scollay JM,Parks RW,de B,I M,M G (2007) Pre-operative high sensitivity C-reactive protein and postoperative outcome in patients undergoing elective orthopaedic surgery Anaesthesia, 62(9), 888 - 894.
25. Ackland GL,Kasymov V,Gourine AV (2007) Physiological and pathophysiological roles of extracellular ATP in chemosensory control of breathing. Biochem Soc Trans, 35(Pt 5), 1264 - 1268. 10.1042/BST0351264.
26. Ackland GL,Mythen MG (2007) Novel biomarkers in critical care: utility or futility? Crit Care, 11(6), 175. 10.1186/cc6127.
27. Ackland GL,Smith M,McGlennan AP (2007) Acute, severe hypoglycemia occurring during general anesthesia in a nondiabetic adult ANESTH ANALG, 105(2), 553 - 554. 10.1213/01.ane.0000268143.05226.a0.
28. Hamilton MA,Mythen MG,Ackland GL (2006) Less is not more: a lack of evidence for intraoperative fluid restriction improving outcome after major elective gastrointestinal surgery Anesthesia and Analgesia, 102(3), 970 - 971.
29. Ackland GL,Mythen MG (2005) Negative pressure pulmonary edema as an unsuspected imitator of acute lung injury/ARDS Chest, 127(5), 1867 - 1868.
30. Ackland GL,Fox R (2005) Low-dose propofol infusion for controlling acute hyperspasticity after withdrawal of intrathecal baclofen therapy. Anesthesiology, 103(3), 663 - 665.
31. Ackland GL,Singh-Ranger D,Fox S,McClaskey B,Down J,Farrar D,Sivaloganathan M,Mythen MG (2004) Assessment of preoperative fluid depletion using bioimpedence analysis British Journal of Anaesthesia, 92(1), 134 - 136.
32. Ackland GL,Gourine AV,Spyer KM (2003) Endotoxin impairs the hypoxic ventilatory response in anaesthetized adult rats INTENSIVE CARE MEDICINE, 29, S86 - S86.
33. Noble R,Ackland G,Hanson MA (1997) Red Nucleus inhibits breathing during hypoxia in neonates. Respiration Physiology, 110, 251 - 260.
34. Moore PJ,Ackland GL,Hanson MA (1996) Unilateral cooling in the region of locus coeruleus blocks the fall in respiratory output during hypoxia in anaesthetized neonatal sheep. Exp Physiol, 81(6), 983 - 994.
35. Noble R,Waites BA,Ackland GL,Hanson MA (1996) Red nucleus lesions abolish the biphasic respiratory response to isocapnic hypoxia in decerebrate young rabbits The Journal of Physiology, 495(1), 217 - 225.
36. ACKLAND GL,WAITES BA,NOBLE R,HANSON MA (1995) BILATERAL LESIONS IN THE RED NUCLEUS ABOLISH THE BIPHASIC RESPIRATORY RESPONSE TO HYPOXIA IN DECEREBRATE NEWBORN RABBITS J PHYSIOL-LONDON, 483P, P89 - P89.
37. WAITES BA,ACKLAND GL,NOBLE R,HANSON MA (1995) MICROINJECTION OF L-GLUTAMATE IN THE RED NUCLEUS PRODUCES INHIBITION OF RESPIRATORY OUTPUT IN DECEREBRATE NEONATAL RABBITS J PHYSIOL-LONDON, 489P, P156 - P156.
38. Ackland GL,Moore PJ,Hanson MA (1994) Is the ventilatory decline seen in newborns during hypoxaemia centrally mediated? Adv Exp Med Biol, 360, 345 - 348.
39. ACKLAND GL,MOORE PJ,HANSON MA (1993) HYPOXIA INHIBITS THE EFFECT ON BREATHING OF TRANSIENT CHEMORECEPTOR STIMULATION IN ANESTHETIZED NEWBORN RABBITS J PHYSIOL-LONDON, 467, P280 - P280.