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Dr Gavin Jell

  • Telephone:

    020 7794 0500

  • Extension:

    #6 292 x35767

  • Email:

    g.jell@ucl.ac.uk

  • Webpage:

    http://www.ucl.ac.uk/nanomed

  • Address:

    UCL Medical School, Royal Free Campus,
    9th Floor, Royal Free Hospital,Pond Street,
    London,
    NW3 2QG

  • Appointments:

    Non-Clinical Lecturer in Nanotechnology and Regenerative Medicine, Research Department of General Surgery, Div of Surgery & Interventional Sci

Summary

 

Research Summary

Investigating the interface between material science and cell biology.
Engineering functional materials to activate specific cellular responses (e.g. the hypoxia pathway) for tissue regeneration. Exploring cellular response to various physicochemical stimuli e.g. surface chemistry, micro and nano-topography, mechanical stress, inorganic ions and physical architecture.

Development of non-invasive Bio-Raman spectroscopy for live biochemical analysis of cells, tissues and tissue engineered constructs. Developing novel strategies for promoting the vascularisation of tissue engineered scaffolds. Other interests include; the in-situ endothelialisation of vascular grafts, bone-implant interface biology, stem cell differentiation, cellular interaction with carbon nanotubes, the biological consequences of orthopaedic wears debris and lymphangiogeneis in regenerative medicine.

Research Activities

  • Bone plug tissue engineering
  • Characterisation of hypoxia in 3D scaffolds
  • Characterisation of stem cell treated osteogenesis imperfect with AFM analysis.
  • Characterisation of tissue engineered constructs
  • HIF-1
  • Polymer nanocomposites for Novel Tissue Engineering Scaffolds
  • Raman spectral analysis and bioactive glasses
  • biophotonic imaging
  • pro-angiogenic materials

Recent Publications

Displaying 35 most recent publications. For the full list please visit UCL Discovery

  1. Sedaghati T,Jell G,Mosahebi A,Butler P,Seifalian AM (2013) Design of novel nanocomposite nerve conduits BRITISH JOURNAL OF SURGERY, 100, 6 - 6.
  2. Sedaghati T,Jell G,Mosahebi A,Butler P,Seifalian AM (2013) Design of novel nanocomposite nerve conduits BRITISH JOURNAL OF SURGERY, 100, 74 - 74.
  3. Ji L,Jell G,Dong Y,Jones JR,Stevens MM (2011) Template synthesis of ordered macroporous hydroxyapatite bioceramics. Chem Commun (Camb), 47(32), 9048 - 9050. 10.1039/c1cc11819f.
  4. Vanleene M,Saldanha Z,Cloyd KL,Jell G,Bou-Gharios G,Bassett JH,Williams GR,Fisk NM,Oyen ML,Stevens MM,Guillot PV,Shefelbine SJ (2011) Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties. Blood, 117(3), 1053 - 1060. 10.1182/blood-2010-05-287565.
  5. Jell G,Swain R,Stevens M (2010) Raman spectroscopy: A tool for Tissue Engineering.. 10.1007/978-3-642-02649-2_18.
  6. Gentleman E,Fredholm YC,Jell G,Lotfibakhshaiesh N,O'Donnell MD,Hill RG,Stevens MM (2010) The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro. Biomaterials, 31(14), 3949 - 3956. 10.1016/j.biomaterials.2010.01.121.
  7. Azevedo MM,Jell G,O'Donnell MD,Law RV,Hill RG,Stevens MM (2010) Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration J MATER CHEM, 20(40), 8854 - 8864. 10.1039/c0jm01111h.
  8. Verdejo R,Jell G,Safinia L,Bismarck A,Stevens MM,Shaffer MSP (2009) Reactive polyurethane carbon nanotube foams and their interactions with osteoblasts Journal of Biomedical Materials Research Part A, 88A(1), 65 - 73.
  9. Gentleman E,Swain RJ,Evans ND,Boonrungsiman S,Jell G,Ball MD,Shean TAV,Oyen ML,Porter A,Stevens MM (2009) Comparative materials differences revealed in engineered bone as a function of cell-specific differentiation Nature Materials, 8(9), 763 - 770.
  10. Jell G,Minelli C,Stevens M (2009) Surface structuring biomaterials.
  11. Swain RJ,Jell G,Stevens MA (2008) Non-invasive analysis of cell cycle dynamics in single living cells with Raman micro-spectroscopy Journal of Cellular Biochemistry, 104(4), 1427 - 1438.
  12. de Mel A,Jell G,Stevens MM,Seifalian AM (2008) Biofunctionalization of biomaterials for accelerated in situ endothelialization: a review. Biomacromolecules, 9(11), 2969 - 2979. 10.1021/bm800681k.
  13. de Mel A,Jell G,Stevens MM,Seifalian AM (2008) Biofunctionalization of Biomaterials for Accelerated in Situ Endothelialization: A Review Biomacromolecules, 9(11), 2969 - 2979.
  14. Jell G,Notingher I,Tsigkou O,Notingher P,Polak JM,Hench LL,Stevens MM (2008) Bioactive glass-induced osteoblast differentiation: A noninvasive spectroscopic study Journal of Biomedical Materials Research Part A, 86A(1), 31 - 40.
  15. Jell G,Verdejo R,Safinia L,Shaffer MSP,Stevens MM,Bismarck A (2008) Carbon nanotube-enhanced polyurethane scaffolds fabricated by thermally induced phase separation Journal of Materials Chemistry, 18(16), 1865 - 1872.
  16. Azevedo M,Jell G,Hill R,Stevens MM (2008) Novel hypoxia mimicking bioactive materials for tissue engineering TISSUE ENGINEERING PART A, 14(5), 889 - 889.
  17. Azevedo M,Jell G,Hill R,Stevens MM (2008) Novel hypoxia mimicking bioactive materials for tissue engineering Tissue Engineering Part A, 14(5), 288.
  18. Gerhardt LC,Jell GMR,Boccaccini AR (2007) Titanium dioxide (TiO2) nanoparticles filled poly(D,L lactid acid) (PDLLA) matrix composites for bone tissue engineering Journal of Materials Science: Materials in Medicine, 18(7), 1287 - 1298.
  19. Jell G,Kerjaschki D,Revell PA,Al-Saffar N (2006) Lymphangiogenesis in the bone-implant interface of orthopedic implants: importance and consequence Journal of Biomedical Materials Research Part A, 77(1), 119 - 127.
  20. Owen CA,Selvakumaran J,Notingher I,Jell G,Hench LL,Stevens MM (2006) In vitro toxicology evaluation of pharmaceuticals using Raman micro-spectroscopy Journal of Cellular Biochemistry, 99(1), 178 - 186.
  21. Jell G,Stevens MM (2006) Gene activation by bioactive glasses Journal of Materials Science: Materials in Medicine, 17(11), 997 - 1002.
  22. Notingher L,Jell G,Notingher PL,Bisson I,Tsigkou O,Polak JM,Stevens MM,Hench LL (2005) Multivariate analysis of Raman spectra for in vitro non-invasive studies of living cells Journal of Molecular Structure, 744, 179 - 185.
  23. Notingher I,Jell G,Notingher PL,Bisson I,Polak JMP,Hench LL (2005) Raman spectroscopy: Potential tool for in situ characterization of bone cell differentiation Bioceramics, 284-286, 545 - 548.
  24. Jell G,Selvakumaran J (2005) Immunochemical techniques in tissue engineering and biomaterial science, 227 - 240.
  25. Jell G,Bonzani I,Stevens MM (2005) Stem cells in regenerative medicine Pharmacuetical Journal, 275, 695 - 698.
  26. Lohbauer U,Jell G,Saravanapavan P,Jones JR,Hench LL (2005) Antimicrobial treatment of dental osseous defects with silver doped bioglass: Osteoblast cell response Bioceramics, 284-286, 435 - 438.
  27. Lohbauer U,Jell G,Saravanapavan P,Jones JR,Hench LL (2005) Indirect cytotoxicity evaluation of silver doped bioglass Ag-S70C30 on human primary keratinocytes Bioceramics, 284-286, 431 - 434.
  28. Kasuga T,Maeda H,Jell G,Notingher I,Hench LL (2005) Preparation of vaterite/poly(lactic acid) composites with excellent apatite-forming ability Bioceramics, 284-286, 449 - 452.
  29. Selvakumaran J,Jell G (2005) A guide to basic cell culture and applications in the field of biomaterials., 215 - 226.
  30. Notingher I,Jell G,Lohbauer U,Salih V,Hench LL (2004) In situ non-invasive spectral discrimination between bone cell phenotypes used in tissue engineering Journal of Cellular Biochemistry, 92(6), 1180 - 1192. 10.1002/jcb.20136.
  31. Owen CA,Notingher I,Jell G,Selvakumaran J,Stevens MM,Hench LL (2004) Raman spectroscopy as a tool for preliminary drug testing on human cells Journal of Pharmacy and Pharmacology, 56(S1), S51 - S52.
  32. Owen CA,Notingher I,Jell G,Selvakumaran J,Stevens MM,Hench LL (2004) Raman spectroscopy as a tool for preliminary drug testing on human cells Journal of Pharmacy and Pharmacology, 56, 140.
  33. Stanley RG,Ngaiza JR,Atieno E,Jell G,Francklow K,Jackson CL,Parry H,Doenhoff MJ (2003) Immune-dependent thrombocytopaenia in mice infected with Schistosoma mansoni Parasitology, 126, 225 - 229.
  34. Jell GMR,Al Saffar N (2001) Does a pro-angiogenic state exist in the bone-implant interface of aseptically loosened joint prosthesis? Journal of Materials Science: Materials in Medicine, 12(10-12), 1069 - 1073.
  35. Jell G,Hill R,Azevedo M,Stevens MM Hypoxia inducing factor (HIF) stabilising glasses..

Biography

 

Qualifications

  • 1998: Master of Science, University of Wales, Bangor
  • 1996: Bachelor of Science, University of Wales, Bangor

Keywords

  • 3D cell culture
  • Adult stem cells
  • Angiogenesis
  • Arthritis
  • Bone
  • Cell culture
  • Cell differentiation
  • Confocal microscopy
  • ELISA
  • Electron Microscopy
  • Enzyme assays
  • FTIR
  • Fluorescence microscopy techniques
  • Glass melting
  • Histology
  • Hypoxic cell sensitisers
  • Imaging (light, EM, X-ray)
  • Immune-based assays
  • Immunohistochemistry
  • Implants
  • In vitro assays of cell function
  • In vitro models
  • Ischaemic preconditioning
  • Materials research
  • Medicine
  • Microspectroscopy
  • Molecular Biology
  • Nanotechnology
  • Osteoblast cultures (bone formation)
  • Osteoclast cultures (bone resorption)
  • Raman
  • Regenerative
  • Tissue Regeneration
  • Tissue engineering
  • Western blotting
  • Wound healing and fibrosis