PHP Code

Using the PHP code extracts allows Academic Staff Profiles to be displayed in a number of different styles including the tabbed format shown below - the data is provided dynamically from the IRIS application, while maintaning the consistent look and feel of your site.

Dr Eugene Schuster

  • Telephone:

    020 7679 2468

  • Fax:

    020 7679 7096

  • Email:

    e.schuster@ucl.ac.uk

  • Address:

    118B Darwin Building,
    Gower Street,
    London,
    WC1E 6BT

  • Appointments:

    Senior Research Fellow, Genetics, Evolution & Environment, Div of Biosciences

Summary

Dr. Eugene Schuster is a MRC Career Development Fellow at UCL in the Institute of Healthy Ageing and G.E.E. Dept.  After a BSc at MIT, he started a PhD at KCL studying DNA methylation relating to Fragile-X Syndrome.  He then spent five years working at the European Bioinformatics Institute as part of the Functional Genomics of Ageing Consortium, working on conserved genes/pathways that regulate lifespan in worms, flies and mice.  He is currently heading a multi-disciplinary team (experimental and computational) that is attempting to develop high-throughput techniques to better understand how certain transcription factors regulate lifespan and influence RNA expression.

Research Summary

Recent ageing studies have revealed a very surprising finding:  Ageing can be regulated.  Even more surprising is that many of the classic signaling pathways that have been exhaustively studied for many years are involved in the regulation of ageing.  Down regulation of the insulin/IGF-1 signaling (IIS) pathway can result in long-lived worms, flies, mice and possibly humans.  Mutations in insulin/insulin-like ligand receptors disrupt a downstream phosphorylation cascade resulting in the nuclear localization of a foxO forhead transcription factor, gene expression changes in hundreds to thousands of genes and long –lived animals.  Our main focus is to understand the mechanisms of foxO gene regulation in long-lived worms and to determine the extent of conversation of these mechanism across a wide range of species.

Research Activities

  • Cell signalling
  • Regulation of Ageing

Recent Publications

Displaying 23 most recent publications. For the full list please visit UCL Discovery

  1. Cabreiro F,Au C,Vergara-Irigaray N,Cocheme HM,Noori T,Weinkove D,Schuster E,Greene NDE,Gems D (2013) Metformin retards aging in C.elegans by altering microbial folate and methionine metabolism Cell, 153, 228 - 239. 10.1016/j.cell.2013.02.035.
  2. Gioti A,Wigby S,Wertheim B,Schuster E,Martinez P,Pennington CJ,Partridge L,Chapman T (2012) Sex peptide of Drosophila melanogaster males is a global regulator of reproductive processes in females Proceedings of the Royal Society B: Biological Sciences. 10.1098/rspb.2012.1634.
  3. Alic N,Andrews TD,Giannakou ME,Papatheodorou I,Slack C,Hoddinott MP,Cocheme HM,Schuster EF,Thornton JM,Partridge L (2011) Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling Mol Syst Biol, 7. 10.1038/msb.2011.36.
  4. Schuster E,McElwee JJ,Tullet JMA,Doonan R,Matthijssens F,Reece-Hoyes JS,Hope IA,Vanfleteren JR,Thornton JM,Gems D (2010) DamID in C-elegans reveals longevity-associated targets of DAF-16/FoxO MOL SYST BIOL, 6. 10.1038/msb.2010.54.
  5. Schuster E,McElwee JJ,Tullett JM,Doonan R,Matthijssens F,Reece-Hoyes JS,Vanfleteren JR,Thornton JM,Gems D (2010) DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO Molecular Systems Biology, 6, 399.
  6. Selman C,Tullet JM,Wieser D,Irvine E,Lingard SJ,Choudhury AI,Claret M,Al-Qassab H,Carmignac D,Ramadani F,Woods A,Robinson IC,Schuster E,Batterham RL,Kozma SC,Thomas G,Carling D,Okkenhaug K,Thornton JM,Partridge L,Gems D,Withers DJ (2009) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science, 326(5949), 140 - 144. 10.1126/science.1177221.
  7. Selman C,Lingard S,Choudhury AI,Batterham RL,Claret M,Clements M,Ramadani F,Okkenhaug K,Schuster E,Blanc E,Piper MD,Al-Qassab H,Speakman JR,Carmignac D,Robinson IC,Thornton JM,Gems D,Partridge L,Withers DJ (2008) Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice The FASEB Journal, 22(3), 807 - 818.
  8. Schuster EF,Blanc E,Partridge L,Thornton J (2007) Correcting for sequence biases in present/absent calls GENOME BIOL, 8(6). 10.1186/gb-2007-8-6-r125.
  9. McElwee JJ,Schuster E,Blanc E,Piper MD,Thomas JH,Patel DS,Selman C,Withers DJ,Thornton JM,Partridge L,Gems DH (2007) Evolutionarily conservation of regulated longevity assurance mechanisms Genome Biology, 8(7), R132. 10.1186/gb-2007-8-7-r132.
  10. Schuster EF,Blanc E,Partridge L,Thornton J (2007) Estimation and correction of non-specific binding in a large-scale spike-in experiment GENOME BIOL, 8(6). 10.1186/gb-2007-8-6-r126.
  11. Selman C,Kerrison ND,Cooray A,Piper MD,Lingard SJ,Barton RH,Schuster EF,Blanc E,Gems D,Nicholson JK,Thornton JM,Partridge L,Withers DJ (2006) Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice Physiol Genomics, 27(3), 187 - 200.
  12. McElwee JJ,Schuster E,Blanc E,Thornton J,Gems D (2006) Erratum to "Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans" [Mech. Ageing Dev. 127 (5) (2006) 458-472] (DOI:10.1016/j.mad.2006.01.006) Mechanisms of Ageing and Development, 127(12), 922 - 936.
  13. McElwee JJ,Schuster E,Blanc E,Thornton J,Gems D (2006) Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. Mech Ageing Dev, 127(5), 458 - 472. 10.1016/j.mad.2006.01.006.
  14. Choi JD,Underkoffler LA,Wood AJ,Collins JN,Williams PT,Golden JA,Schuster EF,Loomes KM,Oakey RJ (2005) A novel variant of Inpp5f is imprinted in brain, and its expression is correlated with differential methylation of an internal CpG island. Mol Cell Biol, 25(13), 5514 - 5522. 10.1128/MCB.25.13.5514-5522.2005.
  15. Wertheim B,Kraaijeveld AR,Schuster E,Blanc E,Hopkins M,Pletcher SD,Strand MR,Partridge L,Godfray HC (2005) Genome-wide gene expression in response to parasitoid attack in Drosophila. Genome Biol, 6(11), R94. 10.1186/gb-2005-6-11-r94.
  16. McElwee JJ,Schuster E,Blanc E,Thomas JH,Gems D (2004) Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance. J Biol Chem, 279(43), 44533 - 44543. 10.1074/jbc.M406207200.
  17. Schuster EF,Stoger R (2002) CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases, 13, 117 - 119.
  18. Peters MA,Jarvik GP,Janer M,Chakrabarti L,Kolb S,Goode EL,Gibbs M,DuBois CC,Schuster EF,Hood L,Ostrander EA,Stanford JL (2001) Genetic linkage analysis of prostate cancer families to Xq27-28, 51, 107 - 113.
  19. Goode EL,Stanford JL,Chakrabarti L,Gibbs M,Kolb S,McIndoe RA,Buckley VA,Schuster EF,Neal CL,Miller EL,Brandzel S,Hood L,Ostrander EA,Jarvik GP (2000) Linkage analysis of 150 high-risk prostate cancer families at 1q24-25, 18, 251 - 275.
  20. Gibbs M,Chakrabarti L,Stanford JL,Goode EL,Kolb S,Schuster EF,Buckley VA,Shook M,Hood L,Jarvik GP,Ostrander EA (1999) Analysis of chromosome 1q42.2-43 in 152 families with high risk of prostate cancer, 64, 1087 - 1095.
  21. Gibbs M,Stanford JL,McIndoe RA,Jarvik GP,Kolb S,Goode EL,Chakrabarti L,Schuster EF,Buckley VA,Miller EL,Brandzel S,Li S,Hood L,Ostrander EA (1999) Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36, 64, 776 - 787.
  22. Aldaz H,Schuster E,Baker TA (1996) The interwoven architecture of the Mu transposase couples DNA synapsis to catalysis. Cell, 85(2), 257 - 269.
  23. BAKER TA,KREMENTSOVA E,SCHUSTER E,LUO L (1995) COMPLETE TRANSPOSITION REQUIRES 4 ACTIVE MONOMERS IN THE MU-TRANSPOSASE TETRAMER J CELL BIOCHEM, 98 - 98.

Biography

Dr. Eugene Schuster is a MRC Career Development Fellow at UCL in the Institute of Healthy Ageing and G.E.E. Dept.  After a BSc at MIT, he started a PhD at KCL studying DNA methylation relating to Fragile-X Syndrome.  He then spent five years working at the European Bioinformatics Institute as part of the Functional Genomics of Ageing Consortium, working on conserved genes/pathways that regulate lifespan in worms, flies and mice.  He is currently heading a multi-disciplinary team (experimental and computational) that is attempting to develop high-throughput techniques to better understand how certain transcription factors regulate lifespan and influence RNA expression.

Qualifications

  • 2004: Doctor of Philosophy, King's College London
  • 1994: Bachelor of Science, Massachusetts Institute of Technology

Keywords

  • Bioinformatics
  • C. elegans
  • Functional Genomics
  • Gene Regulation
  • Transcriptome