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Prof Eleanor Maguire

Summary

Eleanor Maguire undertook her PhD at University College Dublin, Ireland, where she first became interested in the neural basis of navigation and memory while working with patients as a neuropsychologist.  She is currently a Wellcome Trust Senior Research Fellow and Professor of Cognitive Neuroscience at the Wellcome Trust Centre for Neuroimaging at University College London, UK, where she is also the Deputy Head.  In addition, she is an honorary member of the Department of Neuropsychology, National Hospital for Neurology & Neurosurgery, Queen Square, London. Eleanor heads the Memory and Space research laboratory at the Centre, where her team uses whole brain and high resolution structural and functional magnetic resonance imaging in conjunction with neuropsychological examination of patients in order to understand how memories are formed, represented and recollected by the human brain. She has won a number of prizes for outstanding contributions to science, including the Ig Nobel Prize for Medicine - awarded for research promoting the public awareness and understanding of science, the Cognitive Neuroscience Society Young Investigator Award, two Wellcome Trust Senior Research Fellowships, the Royal Society Rosalind Franklin Award, The Feldberg Foundation Prize, and the Dargut and Milena Kemali International Prize.  She has also been elected a Fellow of the Academy of Medical Sciences.

Research Summary

In my work I am trying to understand how memories are formed, represented and recollected by the human brain. We explore this complex issue by studying healthy volunteers as well as patients with memory impairments, using standard and high-resolution structural and functional magnetic resonance imaging (MRI), and neuropsychological testing. 

Keywords: Amnesia, Brain, Brain imaging, Brain injury, Cognitive, Cognition, Connectivity, fMRI, Hippocampus, Imaging, Learning, Neuroscience, Neuropsychology, Memory, MRI, Neuroimaging, Temporal lobes, Neocortex, Autobiographical memory, episodic memory, spatial memory, navigation, retrosplenial cortex, parahippocampal cortex, scene construction

Conditions: Amnesia, Amnesic syndromes, Dementia, Epilepsy

Methods: Functional MRI (fMRI), Magnetic resonance imaging (MRI), Neuropsychological testing, Neuroanatomical approaches, Virtual reality, Neuropsychology, Behavioural analysis, Cross-sectional and cohort studies


Research Activities

  • The neural basis of spatial and episodic memory

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Bonnici HM,Chadwick MJ,Maguire EA (2013) Representations of recent and remote autobiographical memories in hippocampal subfields. Hippocampus. 10.1002/hipo.22155.
  2. Bonnici HM,Sidhu M,Chadwick MJ,Duncan JS,Maguire EA (2013) Assessing hippocampal functional reserve in temporal lobe epilepsy: A multi-voxel pattern analysis of fMRI data. Epilepsy Res, 105(1-2), 140 - 149. 10.1016/j.eplepsyres.2013.01.004.
  3. Mullally SL,Maguire EA (2013) Exploring the role of space-defining objects in constructing and maintaining imagined scenes. Brain Cogn, 82(1), 100 - 107. 10.1016/j.bandc.2013.02.013.
  4. Chadwick MJ,Bonnici HM,Maguire EA (2012) Decoding information in the human hippocampus: a user's guide. Neuropsychologia, 50(13), 3107 - 3121. 10.1016/j.neuropsychologia.2012.07.007.
  5. Bonnici HM,Chadwick MJ,Kumaran D,Hassabis D,Weiskopf N,Maguire EA (2012) Multi-voxel pattern analysis in human hippocampal subfields Frontiers in Human Neuroscience(OCTOBER 2012).
  6. Woollett K,Maguire EA (2012) Exploring anterograde associative memory in London taxi drivers. Neuroreport, 23(15), 885 - 888. 10.1097/WNR.0b013e328359317e.
  7. Maguire EA (2012) Eleanor A. Maguire. Curr Biol, 22(24), R1025 - R1027.
  8. Maguire EA (2012) Studying the freely-behaving brain with fMRI. Neuroimage, 62(2), 1170 - 1176. 10.1016/j.neuroimage.2012.01.009.
  9. Chadwick MJ,Mullally SL,Maguire EA (2012) The hippocampus extrapolates beyond the view in scenes: An fMRI study of boundary extension. Cortex. 10.1016/j.cortex.2012.11.010.
  10. Bonnici HM,Chadwick MJ,Lutti A,Hassabis D,Weiskopf N,Maguire EA (2012) Detecting representations of recent and remote autobiographical memories in vmPFC and hippocampus. J Neurosci, 32(47), 16982 - 16991. 10.1523/JNEUROSCI.2475-12.2012.
  11. Mullally SL,Intraub H,Maguire EA (2012) Attenuated boundary extension produces a paradoxical memory advantage in amnesic patients. Curr Biol, 22(4), 261 - 268. 10.1016/j.cub.2012.01.001.
  12. Mullally SL,Hassabis D,Maguire EA (2012) Scene construction in amnesia: an FMRI study. J Neurosci, 32(16), 5646 - 5653. 10.1523/JNEUROSCI.5522-11.2012.
  13. Zeidman P,Mullally SL,Schwarzkopf DS,Maguire EA (2012) Exploring the parahippocampal cortex response to high and low spatial frequency spaces. Neuroreport, 23(8), 503 - 507. 10.1097/WNR.0b013e328353766a.
  14. Bonnici HM,Kumaran D,Chadwick MJ,Weiskopf N,Hassabis D,Maguire EA (2012) Decoding representations of scenes in the medial temporal lobes. Hippocampus, 22(5), 1143 - 1153. 10.1002/hipo.20960.
  15. Chadwick MJ,Hassabis D,Maguire EA (2011) Decoding overlapping memories in the medial temporal lobes using high-resolution fMRI. Learn Mem, 18(12), 742 - 746. 10.1101/lm.023671.111.
  16. Cooper JM,Vargha-Khadem F,Gadian DG,Maguire EA (2011) The effect of hippocampal damage in children on recalling the past and imagining new experiences. Neuropsychologia, 49(7), 1843 - 1850. 10.1016/j.neuropsychologia.2011.03.008.
  17. Woollett K,Maguire EA (2011) Acquiring "the Knowledge" of London's layout drives structural brain changes. Curr Biol, 21(24), 2109 - 2114. 10.1016/j.cub.2011.11.018.
  18. Mullally SL,Maguire EA (2011) A new role for the parahippocampal cortex in representing space. J Neurosci, 31(20), 7441 - 7449. 10.1523/JNEUROSCI.0267-11.2011.
  19. Maguire EA,Hassabis D (2011) Role of the hippocampus in imagination and future thinking. Proc Natl Acad Sci U S A, 108(11), E39. 10.1073/pnas.1018876108.
  20. Hassabis D,Maguire EA (2011) The construction system of the brain.
  21. Hurley NC,Maguire EA,Vargha-Khadem F (2011) Patient HC with developmental amnesia can construct future scenarios. Neuropsychologia, 49(13), 3620 - 3628. 10.1016/j.neuropsychologia.2011.09.015.
  22. Woollett K,Maguire EA (2010) The effect of navigational expertise on wayfinding in new environments Journal of Environmental Psychology, 30(4), 565 - 573. 10.1016/j.jenvp.2010.03.003.
  23. Chadwick MJ,Hassabis D,Weiskopf N,Maguire EA (2010) Decoding individual episodic memory traces in the human hippocampus. Curr Biol, 20(6), 544 - 547. 10.1016/j.cub.2010.01.053.
  24. Maguire EA,Kumaran D,Hassabis D,Kopelman MD (2010) Autobiographical memory in semantic dementia: a longitudinal fMRI study. Neuropsychologia, 48(1), 123 - 136. 10.1016/j.neuropsychologia.2009.08.020.
  25. Woollett K,Spiers H,Maguire EA (2010) Talent in the taxi: a model system for exploring expertise..
  26. Maguire EA,Vargha-Khadem F,Hassabis D (2010) Imagining fictitious and future experiences: evidence from developmental amnesia. Neuropsychologia, 48(11), 3187 - 3192. 10.1016/j.neuropsychologia.2010.06.037.
  27. Summerfield JJ,Hassabis D,Maguire EA (2010) Differential engagement of brain regions within a 'core' network during scene construction. Neuropsychologia, 48(5), 1501 - 1509. 10.1016/j.neuropsychologia.2010.01.022.
  28. Kumaran D,Maguire EA (2009) Novelty signals: a window into hippocampal information processing. Trends Cogn Sci, 13(2), 47 - 54. 10.1016/j.tics.2008.11.004.
  29. Maguire EA (2009) Routes to memory: neuroplasticity in the hippocampal formation.
  30. Woollett K,Maguire EA (2009) Navigational expertise may compromise anterograde associative memory. Neuropsychologia, 47(4), 1088 - 1095. 10.1016/j.neuropsychologia.2008.12.036.
  31. Summerfield JJ,Hassabis D,Maguire EA (2009) Cortical midline involvement in autobiographical memory. Neuroimage, 44(3), 1188 - 1200. 10.1016/j.neuroimage.2008.09.033.
  32. Hassabis D,Chu C,Rees G,Weiskopf N,Molyneux PD,Maguire EA (2009) Decoding neuronal ensembles in the human hippocampus. Curr Biol, 19(7), 546 - 554. 10.1016/j.cub.2009.02.033.
  33. Hassabis D,Maguire EA (2009) The construction system of the brain. Philos Trans R Soc Lond B Biol Sci, 364(1521), 1263 - 1271. 10.1098/rstb.2008.0296.
  34. Woollett K,Spiers HJ,Maguire EA (2009) Talent in the taxi: a model system for exploring expertise. Philos Trans R Soc Lond B Biol Sci, 364(1522), 1407 - 1416. 10.1098/rstb.2008.0288.
  35. Kumaran D,Summerfield JJ,Hassabis D,Maguire EA (2009) Tracking the emergence of conceptual knowledge during human decision making. Neuron, 63(6), 889 - 901. 10.1016/j.neuron.2009.07.030.
  36. Vann SD,Aggleton JP,Maguire EA (2009) What does the retrosplenial cortex do? Nat Rev Neurosci, 10(11), 792 - 802. 10.1038/nrn2733.
  37. Spiers HJ,Maguire EA (2008) The dynamic nature of cognition during wayfinding. J Environ Psychol, 28(3), 232 - 249. 10.1016/j.jenvp.2008.02.006.
  38. Maguire E (2008) Hail taxi drivers! NEW SCIENTIST, 198(2660), 20 - 21.
  39. Woollett K,Glensman J,Maguire EA (2008) Non-spatial expertise and hippocampal gray matter volume in humans. Hippocampus, 18(10), 981 - 984. 10.1002/hipo.20465.
  40. Hassabis D,Kumaran D,Maguire EA (2007) Using imagination to understand the neural basis of episodic memory. J Neurosci, 27(52), 14365 - 14374. 10.1523/JNEUROSCI.4549-07.2007.
  41. Spiers HJ,Maguire EA (2007) Neural substrates of driving behaviour. Neuroimage, 36(1), 245 - 255. 10.1016/j.neuroimage.2007.02.032.
  42. Spiers HJ,Maguire EA (2007) A navigational guidance system in the human brain. Hippocampus, 17(8), 618 - 626. 10.1002/hipo.20298.
  43. Hassabis D,Maguire EA (2007) Deconstructing episodic memory with construction. Trends Cogn Sci, 11(7), 299 - 306. 10.1016/j.tics.2007.05.001.
  44. Kumaran D,Maguire EA (2007) Match mismatch processes underlie human hippocampal responses to associative novelty. J Neurosci, 27(32), 8517 - 8524. 10.1523/JNEUROSCI.1677-07.2007.
  45. Spiers HJ,Maguire EA (2007) Decoding human brain activity during real-world experiences. Trends Cogn Sci, 11(8), 356 - 365. 10.1016/j.tics.2007.06.002.
  46. Hassabis D,Kumaran D,Vann SD,Maguire EA (2007) Patients with hippocampal amnesia cannot imagine new experiences. Proc Natl Acad Sci U S A, 104(5), 1726 - 1731. 10.1073/pnas.0610561104.
  47. Kumaran D,Hassabis D,Spiers HJ,Vann SD,Vargha-Khadem F,Maguire EA (2007) Impaired spatial and non-spatial configural learning in patients with hippocampal pathology. Neuropsychologia, 45(12), 2699 - 2711. 10.1016/j.neuropsychologia.2007.04.007.
  48. Spiers HJ,Maguire EA (2007) The neuroscience of remote spatial memory: a tale of two cities. Neuroscience, 149(1), 7 - 27. 10.1016/j.neuroscience.2007.06.056.
  49. Kumaran D,Maguire EA (2007) Which computational mechanisms operate in the hippocampus during novelty detection? Hippocampus, 17(9), 735 - 748. 10.1002/hipo.20326.
  50. Maguire EA (2007) Spatial navigation, 131 - 145.

Biography

Eleanor Maguire undertook her PhD at University College Dublin, Ireland, where she first became interested in the neural basis of navigation and memory while working with patients as a neuropsychologist.  She is currently a Wellcome Trust Senior Research Fellow and Professor of Cognitive Neuroscience at the Wellcome Trust Centre for Neuroimaging at University College London, UK, where she is also the Deputy Head.  In addition, she is an honorary member of the Department of Neuropsychology, National Hospital for Neurology & Neurosurgery, Queen Square, London. Eleanor heads the Memory and Space research laboratory at the Centre, where her team uses whole brain and high resolution structural and functional magnetic resonance imaging in conjunction with neuropsychological examination of patients in order to understand how memories are formed, represented and recollected by the human brain. She has won a number of prizes for outstanding contributions to science, including the Ig Nobel Prize for Medicine - awarded for research promoting the public awareness and understanding of science, the Cognitive Neuroscience Society Young Investigator Award, two Wellcome Trust Senior Research Fellowships, the Royal Society Rosalind Franklin Award, The Feldberg Foundation Prize, and the Dargut and Milena Kemali International Prize.  She has also been elected a Fellow of the Academy of Medical Sciences.

Qualifications

  • 1994: Doctor of Philosophy, University College Dublin
  • 1991: Master of Science, University of Wales, Swansea
  • 1990: Bachelor of Arts (Honours), University College Dublin

Keywords

  • Adult language processing
  • Amnesia
  • Amnesic syndromes
  • Behavioural analysis
  • Brain
  • Brain imaging
  • Brain injury
  • Cognition
  • Cognitive
  • Connectivity
  • Cross-sectional and cohort studies
  • Dementia - frontotemporal
  • Epilepsy
  • Functional MRI (fMRI)
  • Hippocampus
  • Imaging
  • Learning
  • Magnetic resonance imaging (MRI)
  • Memory
  • Neocortex
  • Neuroanatomical approaches
  • Neuroimaging
  • Neuropsychological testing
  • Neuroscience
  • Phonological Development
  • Psychometrics
  • Spatial and episodic memory in health and disease
  • Spatial learning
  • Temporal lobes
  • Virtual reality

Collaborators