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Prof Edward Tuddenham

  • Extension:

    020 7830 2334

  • Email:

    e.tuddenham@ucl.ac.uk

  • Appointments:

    Professorial Research Associate, Research Department of Haematology, Cancer Institute
No image is available

Research Activities

  • Gene therapy for haematological disorders
  • Investigation of the genetic causes of haemophilia

Recent Publications

Displaying 22 most recent publications. For the full list please visit UCL Discovery

  1. Malam Y,Tsui J,Sheikh SE,Tuddenham EG,Baker DM (2012) Journal rubric. Haemophilic pseudotumour of the carotid artery. Vasc Med, 17(3), 193 - 194. 10.1177/1358863X11429998.
  2. Binny C,McIntosh J,Della Peruta M,Kymalainen H,Tuddenham EGD,Buckley SMK,Waddington SN,McVey JH,Spence Y,Morton CL,Thrasher AJ,Gray JT,Castellino FJ,Tarantal AF,Davidoff AM,Nathwani AC (2012) AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage BLOOD, 119(4), 957 - 966. 10.1182/blood-2011-09-377630.
  3. Davidoff A,Tuddenham EGD,Rangarajan S,Rosales C,McIntosh J,Chowdary P,Riddell A,Glader B,Rustagi P,Ng C,Kay M,Zhou J,Spence Y,Morton C,Allay J,Sleep S,Basner-Tschakarjan E,Mingozzi F,High KA,Gray JT,Reiss UM,Nienhuis AW,Nathwani AC (2012) Stable Factor IX Activity Following AAV-Mediated Gene Transfer in Patients with Severe Hemophilia B BLOOD, 120(21).
  4. Nathwani AC,Tuddenham EG,Rangarajan S,Rosales C,McIntosh J,Linch DC,Chowdary P,Riddell A,Pie AJ,Harrington C,O'Beirne J,Smith K,Pasi J,Glader B,Rustagi P,Ng CY,Kay MA,Zhou J,Spence Y,Morton CL,Allay J,Coleman J,Sleep S,Cunningham JM,Srivastava D,Basner-Tschakarjan E,Mingozzi F,High KA,Gray JT,Reiss UM,Nienhuis AW,Davidoff AM (2011) Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. N Engl J Med, 365(25), 2357 - 2365. 10.1056/NEJMoa1108046.
  5. Nathwani AC,Tuddenham EGD,Rangarajan S,Rosales C,McIntosh JH,Linch DC,Chowdary P,Griffioen A,Riddell A,Pie J,Harrington C,O'Beirne J,Smith K,Pasi J,Glader B,Rustagi P,Ng C,Kay M,Zhou J,Spence Y,Morton C,Allay J,Coleman J,Sleep S,Cunningham JM,Basner-Tschakarjan E,Mingozzi F,High KA,Gray JT,Reiss UM,Nienhuis AW,Davidoff A (2011) Adeno-Associated Viral Vector Mediated Gene Transfer for Hemophilia B BLOOD, 118(21), 4 - 5.
  6. Nathwani A,Tuddenham EGD,Rosales C,Macintosh J,Chowdary P,Riddell A,Aghighi S,Griffioen A,Pie J,Harrington C,Glader B,Ng CYC,Kay M,Zhou J,Allay J,Coleman J,Sleep S,High K,Mingozzi F,Gray JT,Reiss UM,Nienhuis AW,Davidoff AM (2011) A Phase I/II clinical trial entailing peripheral vein administration of a novel self complementary adeno-associated viral vector encoding human FIX for Haemophilia B gene therapy HUMAN GENE THERAPY, 22(10), A20 - A20.
  7. Ward NJ,Buckley SM,Waddington SN,Vandendriessche T,Chuah MK,Nathwani AC,McIntosh J,Tuddenham EG,Kinnon C,Thrasher AJ,McVey JH (2011) Codon optimization of human factor VIII cDNAs leads to high-level expression. Blood, 117(3), 798 - 807. 10.1182/blood-2010-05-282707.
  8. Nathwani AC,Tuddenham EGD,Rosales C,Macintosh J,Chowdary P,Riddell A,Aghighi S,Lilley P,Yee T,Griffioen A,Pie J,Harrington C,Glader B,Ng CYC,Kaye M,Zhou JF,Allay J,Coleman J,Sleep S,High K,Mingozzi F,Gray JT,Reiss UM,Nienhuis AW,Davidoff AM (2011) A phase i/ii clinical trial entailing peripheral vein administration of a novel self complementary adeno-associated viral vector encoding human fix for haemophilia b gene therapy HUMAN GENE THERAPY, 22(6), A7 - A8.
  9. Mitchison NA,Bhattacharya S,Tuddenham EG (2011) Human congenital diseases with mixed modes of inheritance have a shortage of recessive disease. A demographic scenario? Ann Hum Genet, 75(6), 688 - 693. 10.1111/j.1469-1809.2011.00679.x.
  10. Nathwani AC,Tuddenham EGD,Rosales C,McIntosh J,Riddell A,Rustagi P,Galder B,Kay M,Allay J,Coleman J,Sleep S,High KA,Mingozzi F,Gray J,Reiss U,Nienhuis AW,Davidoff AM (2010) Early clinical trial results following administration of a low dose of a novel self complementary adenohyphen;associated viral vector encoding human factor ix in two subjects with severe Haemophilia B HUMAN GENE THERAPY, 21(10), 1362 - 1362.
  11. Saunders RE,Shiltagh N,Gomez K,Mellars G,Cooper C,Perry DJ,Tuddenham EG,Perkins SJ (2009) Structural analysis of eight novel and 111 previously reported missense mutations in the interactive FXI mutation database reveals new insight on FXI deficiency. Thrombosis and Haemostasis, 102(2), 183 - 420. 10.1160/TH09-01-0044.
  12. Nathwani AC,Gray JT,McIntosh J,Ng CY,Zhou J,Spence Y,Cochrane M,Gray E,Tuddenham EG,Davidoff AM (2007) Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates. Blood, 109(4), 1414 - 1421. 10.1182/blood-2006-03-010181.
  13. Mcintosh J,Cochrane M,Tuddenham EGD,Davidoff AM,Nathwani AC (2006) Expression of human FIX at therapeutic levels in nonhuman primates following a single peripheral vein infusion of low doses of self complementary AAV vector renews hope for haemophilia B gene therapy BRITISH JOURNAL OF HAEMATOLOGY, 133, 18 - 18.
  14. Zhang B,McGee B,Yamaoka JS,Guglielmone H,Downes KA,Minoldo S,Jarchum G,Peyvandi F,de Bosch NB,Ruiz-Saez A,Chatelain B,Olpinski M,Bockenstedt P,Sperl W,Kaufman RJ,Nichols WC,Tuddenham EG,Ginsburg D (2006) Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2. Blood, 107(5), 1903 - 1907. 10.1182/blood-2005-09-3620.
  15. Nathwani AC,Gray JT,Ng CY,Zhou J,Spence Y,Waddington SN,Tuddenham EG,Kemball-Cook G,McIntosh J,Boon-Spijker M,Mertens K,Davidoff AM (2006) Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver. Blood, 107(7), 2653 - 2661.
  16. Chakraverty R,Craddock C (2005) Stem Cell Transplantation.
  17. Rost S,Fregin A,Ivaskevicius V,Conzelmann E,Hortnagel K,Pelz HJ,Lappegard K,Seifried E,Scharrer I,Tuddenham EG,Muller CR,Strom TM,Oldenburg J (2004) Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature, 427(6974), 537 - 541. 10.1038/nature02214.
  18. Nathwani AC,Davidoff AM,Tuddenham EG (2004) Prospects for gene therapy of haemophilia. Haemophilia, 10(4), 309 - 318.
  19. Waddington SN,Nivsarkar M,Mistry A,Buckley SMK,Kemball-Cook G,Mosley KL,Mitrophanous K,Radcliffe P,Holder M,Brittan M,Georgiadis T,Al-Allaf F,Bigger B,Gregory L,Cook HT,Ali RR,Thrasher A,Tuddenham EGD,Themis M,Coutelle C (2004) Permanent phenotypic correction of Haemophilia B in immunocompetent mice by prenatal gene therapy JOURNAL OF GENE MEDICINE, 6(9), S17 - S17.
  20. Waddington SN,Nivsarkar MS,Mistry AR,Buckley SM,Kemball-Cook G,Mosley KL,Mitrophanous K,Radcliffe P,Holder MV,Brittan M,Georgiadis A,Al-Allaf F,Bigger BW,Gregory LG,Cook HT,Ali RR,Thrasher A,Tuddenham EG,Themis M,Coutelle C (2004) Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy. Blood, 104(9), 2714 - 2721. 10.1182/blood-2004-02-0627.
  21. Zhang B,Cunningham MA,Nichols WC,Bernat JA,Seligsohn U,Pipe SW,McVey JH,Schulte-Overberg U,de Bosch NB,Ruiz-Saez A,White GC,Tuddenham EG,Kaufman RJ,Ginsburg D (2003) Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex. Nature Genetics, 34(2), 220 - 225. 10.1038/ng1153.
  22. Nathwani AC,Tuddenham EG (1992) Epidemiology of coagulation disorders. Baillière's Clinical Haematology, 5(2), 383 - 439.

Qualifications

  • 1975: Member of the Royal College of Physicians, Royal College of Physicians
  • 1968: Bachelor of Medicine/Bachelor of Surgery, London