Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

1. Selwood DL (2013) Beyond the Hundred Dollar Genome - Drug Discovery Futures Chemical Biology and Drug Design, 81(1), 1 - 4.
2. Gooding M,Tudzarova S,Worthington RJ,Kingsbury SR,Rebstock A-S,Dube H,Simone MI,Visintin C,Lagos D,Quesada J-MF,Laman H,Boshoff C,Williams GH,Stoeber K,Selwood DL (2012) Exploring the interaction between siRNA and the SMoC biomolecule transporters: Implications for small molecule-mediated delivery of siRNA Chemical Biology and Drug Design, 79(1), 9 - 21.
3. Selwood DL (2012) The Role of Chemical Biology in Understanding and Treating Disease—Are Small Molecule “Correctors” the Way of the Future?, II, 205 - 214.
4. Soininen SK,Lehtolainen-Dalkilic P,Karppinen T,Puustinen T,Dragneva G,Kaikkonen MU,Jauhiainen M,Allart B,Selwood DL,Wirth T,Lesch HP,Määttä AM,Mönkkönen J,Ylä-Herttuala S,Ruponen M (2012) Targeted delivery via avidin fusion protein: intracellular fate of biotinylated doxorubicin derivative and cellular uptake kinetics and biodistribution of biotinylated liposomes. Eur J Pharm Sci, 47(5), 848 - 856. 10.1016/j.ejps.2012.09.001.
5. Dube H,Selwood D,Malouitre S,Capano M,Simone MI,Crompton M (2012) A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes. Biochem J, 441(3), 901 - 907. 10.1042/BJ20111301.
6. Selwood D (2012) Marvellous chemical biology tools and other matters. Chem Biol Drug Des, 79(1), 1. 10.1111/j.1747-0285.2011.01273.x.
7. Gooding M,Tudzarova S,Worthington RJ,Kingsbury SR,Rebstock AS,Dube H,Simone MI,Visintin C,Lagos D,Quesada JM,Laman H,Boshoff C,Williams GH,Stoeber K,Selwood DL (2012) Exploring the interaction between siRNA and the SMoC biomolecule transporters: implications for small molecule-mediated delivery of siRNA. Chem Biol Drug Des, 79(1), 9 - 21. 10.1111/j.1747-0285.2011.01249.x.
8. Gooding M,Browne LP,Quinteiro FM,Selwood DL (2012) siRNA delivery: from lipids to cell-penetrating peptides and their mimics. Chem Biol Drug Des, 80(6), 787 - 809. 10.1111/cbdd.12052.
9. Djordievic S,Allerston CK,Jarvis A,Jia HY,Herzog B,Garza-Garcia A,Driscoll PC,Zachary I,Selwood D (2011) Small molecule inhibitors of the neuropilin-1 VEGF-A interaction INT J MOL MED, 28, S24 - S24.
10. Malouitre S,Dube H,Selwood D,Crompton M (2010) Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation. Biochemical Journal, 425, 137 - 148. 10.1042/BJ20090332.
11. Jarvis A,Allerston CK,Jia H,Herzog B,Garza-Garcia A,Winfield N,Ellard K,Aqil R,Lynch R,Chapman C,Hartzoulakis B,Nally J,Stewart M,Cheng L,Menon M,Tickner M,Djordjevic S,Driscoll PC,Zachary I,Selwood DL (2010) Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem, 53(5), 2215 - 2226. 10.1021/jm901755g.
12. Chan AW,Laskowski RA,Selwood DL (2010) Chemical fragments that hydrogen bond to Asp, Glu, Arg, and His side chains in protein binding sites. J Med Chem, 53(8), 3086 - 3094. 10.1021/jm901696w.
13. Jia H,Cheng L,Tickner M,Bagherzadeh A,Selwood D,Zachary I (2010) Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity. British Journal of Cancer, 102(3), 541 - 552. 10.1038/sj.bjc.6605539.
14. Selwood DL (2010) Process for preparing carboxylic acid amides useful in the treatment of muscular disorders.
15. Sofia S,Gareth P,Greg M,Sam J,David S,David B (2010) GPR55 as a novel target for disease control in multiple sclerosis JOURNAL OF NEUROIMMUNOLOGY, 228(1-2), 41 - 41.
16. Vozzolo L,Loh B,Gane PJ,Tribak M,Zhou L,Anderson I,Nyakatura E,Jenner RG,Selwood D,Fassati A (2010) Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein. J Biol Chem, 285(50), 39314 - 39328. 10.1074/jbc.M110.155275.
17. Hobbs AJ,Gane P,Lumsden N,Nobles M,Rebstock A-S,Simone M,Villar I,Worthington R,Xiao F,Ahluwalia A,Selwood D (2009) Design and development of novel non-peptide agonists at natriuretic peptide receptor-C FASEB JOURNAL, 23.
18. Gratzke C,Weinhold P,Selwood D,Stief CG,Andersson KE,Hedlund P (2009) DISTRIBUTION OF THE G-PROTEIN-COUPLED RECEPTOR 55 (GPR55) IN THE RAT BLADDER AND URODYNAMIC EFFECTS OF A SELECTIVE GPR55-AGONIST IN CONSCIOUS RATS EUR UROL SUPPL, 8(4), 271 - 271.
19. Selwood D,Rebstock AS,Visintin C (2009) PROCESS FOR THE PREPARATION OF GUANIDINO SUBSTITUTED BI-AND POLYPHENYLS THAT ARE SUITABLE AS SMALL MOLECULE CARRIERS.
20. Clutterbuck LA,Posada CG,Visintin C,Riddall DR,Lancaster B,Gane PJ,Garthwaite J,Selwood DL (2009) Oxadiazolylindazole Sodium Channel Modulators are Neuroprotective toward Hippocampal Neurones Journal of Medicinal Chemistry, 52(9), 2694 - 2707. 10.1021/jm801180p.
21. Rebstock AS,Visintin C,Leo E,Garcia Posada C,Kingsbury SR,Williams GH,Stoeber K,Selwood DL (2008) Modular assembly using sequential palladium coupling gives easy access to the SMoC class of cellular transporters. ChemBioChem, 9(11), 1787 - 1796.
22. Jia H,Zachary I,Tickner M,Cheng L,Chapman C,Ellard K,Hartzoulakis B,Jarvis A,Lynch R,Nally J,Selwood D,Stewart M (2008) ARGININE DERIVATIVES WITH NP-I ANTAGONISTIC ACTIVITY.
23. Jia H,Bagherzadeh A,Zachary I,Tickner M,Chapman C,Jarvis A,Selwood D (2008) SHORT PEPTIDIC NEUROPILIN-1 ANTAGONISTS AND THEIR USE.
24. Selwood D,Jia H,Zachary I,Tickner M,Aqil R,Shaikh S,Chapman C,Jarvis A (2008) N-CAPPED PEPTIDES WITH NP-1 ANTAGONIST ACTIVITY.
25. Baliga RS,Zhao L,Madhani M,Lopez-Torondel B,Visintin C,Selwood D,Wilkins MR,MacAllister RJ,Hobbs AJ (2008) Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension. American Journal of Respiratory and Critical Care Medicine, 178(8), 861 - 869. 10.1164/rccm.200801-121OC.
26. Hoi PM,Visintin C,Okuyama M,Gardiner SM,Kaup SS,Bennett T,Baker D,Selwood DL,Hiley CR (2007) Vascular pharmacology of a novel cannabinoid-like compound, 3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-hydroxy-1-methyl-ethyl)benzamide (VSN16) in the rat. British Journal of Pharmacology, 152(5), 751 - 764. 10.1038/sj.bjp.0707470.
27. Hartzoulakis B,Rossiter S,Gill H,O'Hara B,Steinke E,Gane PJ,Hurtado-Guerrero R,Leiper JM,Vallance P,Rust JM,Selwood DL (2007) Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis. Bioorganic and Medicinal Chemistry Letters, 17(14), 3953 - 3956. 10.1016/j.bmcl.2007.04.095.
28. Leiper J,Nandi M,Torondel B,Murray-Rust J,Malaki M,O'Hara B,Rossiter S,Anthony S,Madhani M,Selwood D,Smith C,Wojciak-Stothard B,Rudiger A,Stidwill R,McDonald NQ,Vallance P (2007) Disruption of methylarginine metabolism impairs vascular homeostasis Nature Medicine, 13(2), 198 - 203.
29. Okuyama M,Laman H,Kingsbury SR,Visintin C,Leo E,Eward KL,Stoeber K,Boshoff C,Williams GH,Selwood DL (2007) Small-molecule mimics of an alpha-helix for efficient transport of proteins into cells Nature Methods, 4(2), 153 - 159. 10.1038/nmeth997.
30. Jia H,Bagherzadeh A,Hartzoulakis B,Jarvis A,Lohr M,Shaikh S,Aqil R,Cheng L,Tickner M,Esposito D,Harris R,Driscoll PC,Selwood DL,Zachary IC (2006) Characterization of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of vascular endothelial growth factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling. Journal of Biological Chemistry, 281(19), 13493 - 13502.
31. Matthews N,Visintin C,Hartzoulakis B,Jarvis A,Selwood DL (2006) Aurora A and B kinases as targets for cancer: will they be selective for tumors? Expert Rev Anticancer Ther., 6(1), 109 - 120. 10.1586/14737140.6.1.109.
32. Aliev AE,Hilton ST,Motherwell WB,Selwood DL (2006) A concise approach to the epidithiodiketopiperazine (ETP) core Tetrahedron Letters, 47(14), 2387 - 2390. 10.1016/j.tetlet.2006.01.156.
33. McLean SR,Gana-Weisz M,Hartzoulakis B,Frow R,Whelan J,Selwood D,Boshoff C (2005) Imatinib binding and cKIT inhibition is abrogated by the cKIT kinase domain I missense mutation Val(654)Ala Molecular Cancer Therapeutics, 4(12), 2008 - 2012.
34. Hilton ST,Motherwell WB,Potier P,Pradet C,Selwood DL (2005) Observations on the reactivity of thiyl radicals derived from 3,6-epidithiodiketopiperazine-2,5-diones and related congeners Bioorganic and Medicinal Chemistry Letters(15), 2239 - 2242.
35. Rossiter S,Smith CL,Malaki M,Nandi M,Gill H,Leiper JM,Vallance P,Selwood DL (2005) Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase Journal of Medicinal Chemistry, 48(14), 4670 - 4678.
36. Rossiter S,Smith CL,Malaki M,Gill H,Leiper J,Vallance P,Selwood DL (2005) Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase Journal of Medicinal Chemistry, Jul 14;48(14), 4670 - 4678.
37. Visintin C,Aliev AE,Riddall D,Baker D,Okuyama M,Man Hoi P,Hiley R,Selwood DL (2005) Membrane receptor probes: solid-phase synthesis of biotin-Asp-PEG-arvanil derivatives Organic Letters, 7(9), 1699 - 1702.
38. Stoeber K,Eward KL,Kingsbury SR,Okorokov AL,Madge D,Selwood DL,Williams GH (2005) Development of geminin mimetics as novel anti-proliferative agents JOURNAL OF PATHOLOGY, 207, 6 - 6.
39. Selwood D,Visintin C,Baker D,Pryce G,Okuyama M (2004) MODULATOR.
40. Okuyama M,Selwood D,Visintin C,Baker D,Pryce G (2004) MODULATORS OF CANNABINOID RECEPTORS.
41. Cheng L,Jia H,Lohr M,Bagherzadeh A,Holmes DIR,Selwood D,Zachary I (2004) Anti-chemorepulsive effects of vascular endothelial growth factor and placental growth factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid production. Journal of Biological Chemistry, 279(29), 30654 - 30661. 10.1074/jbc.M402488200.
42. Hakkinen M,Mantyla T,Lehtolainen P,Selwood D,Yla-Herttuala S,Vepsalainen J,Narvanen A (2004) AN EFFICIENT METHOD FOR PARALLEL SYNTHESIS OF MULTIFUNCTIONAL MOLECULES IN THE SCAVIDIN MEDIATED CELL MEMBRANE TRANSPORT J PEPT SCI, 10, 163 - 163.
43. Hilton ST,Motherwell WB,Selwood DL (2004) An Expedient Entry into the a-Mercaptodiketopiperazine Nucleus Synlett(14), 2609 - 2611.
44. Selwood D (2004) Book Review: Anticancer Drug Development: Preclinical Screening, Clinical Trials and Approval Br J Cancer, 91, 1000 - 1000. 10.1038/sj.bjc.6602070.
45. Rossiter S,Woo CK,Hartzoulakis B,Wishart G,Stanyer L,Labadie JW,Selwood DL (2004) Copper (II)-mediated arylation with aryl boronic acids for the N-derivatization of pyrazole libraries. J Comb Chem, 6(3), 385 - 390. 10.1021/cc034065k.
46. Teicher BA,Selwood DL,Andrews PA (2004) Anticancer drug development: preclinical screening, clinical trials and approval (vol 91, pg 1000, 2004) BRIT J CANCER, 91(11), 1977 - 1977. 10.1038/sj.bjc.6602286.
47. Selwood D,visintin C,Laman H,Okuyama M (2004) BI- OR TETRA-GUANIDINO-BIPHENYL COMPOUNDS AS SMALL MOLECULE CARRIERS.
48. Vallance PJT,Leiper JM,Selwood DL,Rossiter S,Hartzoulakis B (2004) CHEMICAL COMPOUNDS.
49. Allart B,Lehtolainen P,Yla-Herttuala S,Martin JF,Selwood D (2003) A stable bis-allyloxycarbonyl biotin aldehyde derivative for biotinylation via reductive alkylation: Application to the synthesis of a biotinylated doxorubicin derivative Bioconjugate Chemistry, 14, 187 - 194.
50. Lohr M,Kibler KV,Zachary I,Jeang KT,Selwood DL (2003) Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells Biochemical and Biophysical Research Communications, 300(2), 609 - 613.