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Prof Andres Ruiz-Linares

Contact
Research
Publications
Biography
Additional

Telephone:
020 3108 4003
Extension:
54003
Fax:
020 7679 7193
Email:
a.ruizlin@ucl.ac.uk
Webpage:
http://www.ucl.ac.uk/~ucbtarl
Address:
218-B Department of Genetics, Evolution and Environment,
Gower Street ,
London,
WC1E 6BT
Appointments:

Professor of Human Genetics, Genetics, Evolution & Environment, Div of Biosciences

Summary

Education/Qualifications: ·

M.D., Colegio Mayor de Nuestra Senora del Rosario, Bogotá, Colombia. First Class 1984.

M. Sc. (Biochemistry), Université de Paris VII, Paris, France. 1987.

Ph. D. (Genetics), University of Cambridge, Cambridge, England. 1991.

Professional History

1986-1988 Graduate Student. Laboratoire de Virologie Moleculaire, Institut Pasteur (Dr. Marc Girard), Paris, France.

1988-1991 Ph.D. Student. Department of Genetics, University of Cambridge (Dr. Gabriel Dover) Cambridge, UK.

1992-1994 Postdoctoral Fellow. Department of Genetics, Stanford University Medical School(Dr. Luca Cavalli-Sforza), Stanford, California, U.S.A.

1994-1998 Assistant Professor, Department of Biochemistry, Universidad de Antioquia Medical School, Medellín, Colombia.

1998-2000 Lecturer (non-clinical). Department of Medical and Community Genetics. Imperial College School of Medicine, London, UK.

October 2000: Lecturer. Department of Biology (Galton Laboratory), University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE. U.K.

October 2004: Senior Lecturer. Department of Biology (Galton Laboratory), University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE. U.K.

October 2006- Current: Professor of Human Genetics Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE. U.K.

Research Summary

We have been exploring patterns of diversity in Native Americans using autosomal, sex- chromosome and mtDNA markers in order to examine the process of initial settlement of the Americas, the pattern of population dispersal in the continent and the relationship of genetic data to other sources of historical information (1,2,4). We are also interested in probing the genetic history of recently established Latin American populations seeking to characterize the process of European, Native American and African admixture in the region (3,5).

1 Yang et al. (2010) Contrasting patterns of nuclear and mtDNA diversity in Native American populations. Annals of Human Genetics

2- Ray et al. (2010) A statistical evaluation of models for the initial settlement of the American continent emphasizes the importance of gene flow with Asia. Mol Biol Evol. 27:337-45.

3- Wang et al. (2008) Geographic patterns of genome admixture in Latin American Mestizos PLoS Genet 4: e1000037

4- Wang et al. (2007) Genetic variation and population structure in Native Americans. PLoS Genetics 3:185.

5- Bedoya (2006) Admixture dynamics in Hispanics: a shift in the nuclear genetic ancestry of a South American population isolate. Proc Natl.Acad.Sci.U.S.A 103, 7234-7239.

We have also been interested in exploiting properties of certain Latin American populations that could facilitate gene identifiation: geographic isolation, admixture and rapid demographic growth. This has led us to apply linkage and association approaches to both Mendelian (1) and complex disorders (3,5). We have been interested in the development and application of mapping genetic methods tailored to recently admixed populations (2,4). We recently initiated a large study aimed at identifying genes underlying the differentiated physical appearance of Native Americans and Europeans using a combined association/admixture mapping approach in admixed Latin American populations.

1- Kremeyer et al (2010) A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Neuron. 66:671-80.

2- Florez et al (2009) Strong association of socioeconomic status with genetic ancestry in Latinos: implications for admixture studies of type 2 diabetes. Diabetologia. 52: 1528-1536.

3- Jasinska et al. (2009) Narrow and Highly Significant Linkage Signal for Severe Bipolar Disorder in the Chromosome 5q33 Region in Latin American Pedigrees. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150:998-1006.

4- Price (2007) A genomewide admixture map for latino populations. Am.J.Hum.Genet. 80, 1024-1036.

5- Herzberg . (2006) Convergent linkage evidence from two Latin-American population isolates supports the presence of a susceptibility locus for bipolar disorder in 5q31-34. Hum.Mol.Genet. 15, 3146-3153.

Research Activities

Use of genetic variation in the study of demographic history
Evolutionary Genetics
Genetic Epidemiology
Genetic basis of neurological disease
Genetic polymorphism
Genetic studies of neurological disease
Genetics
Genetics of brain disorders
Human genetic variation affecting function
Molecular genetics
Molecular genetics of childhood inherited disorder
genetics of face and object perception
pharmacogenetics
population genetics

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

Gómez-Valdés JA,Hünemeier T,Contini V,Acuña-Alonzo V,Macin G,Ballesteros-Romero M,Corral P,Ruiz-Linares A,Sánchez-Mejorada G,Canizales-Quinteros S,Martínez-Abadías N,Salzano FM,González-José R,Bortolini MC (2013) Fibroblast growth factor receptor 1 (FGFR1) variants and craniofacial variation in Amerindians and related populations. Am J Hum Biol, 25(1), 12 - 19. 10.1002/ajhb.22331.
Hünemeier T,Amorim CE,Azevedo S,Contini V,Acuña-Alonzo V,Rothhammer F,Dugoujon JM,Mazières S,Barrantes R,Villarreal-Molina MT,Paixão-Côrtes VR,Salzano FM,Canizales-Quinteros S,Ruiz-Linares A,Bortolini MC (2012) Evolutionary responses to a constructed niche: ancient Mesoamericans as a model of gene-culture coevolution. PLoS One, 7(6), e38862. 10.1371/journal.pone.0038862.
Rojas W,Parra MV,Campo O,Caro MA,Lopera JG,Arias W,Duque C,Naranjo A,Garcia J,Vergara C,Lopera J,Hernandez E,Valencia A,Caicedo Y,Torres MM,Groot de Restrepo H,Cuartas M,Gutierrez J,Lopez S,Ruiz-Linares A,Bedoya G (2012) Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers (vol 143, pg 13, 2010) AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 147(1), 168 - 168. 10.1002/ajpa.21642.
Pardo LM,Piras G,Asproni R,van der Gaag KJ,Gabbas A,Ruiz-Linares A,de Knijff P,Monne M,Rizzu P,Heutink P (2012) Dissecting the genetic make-up of North-East Sardinia using a large set of haploid and autosomal markers. Eur J Hum Genet, 20(9), 956 - 964. 10.1038/ejhg.2012.22.
Amorim CEG,Wang S,Ruiz-Linares A,Bortolini MC,Bonatto SL,Salzano FM (2012) X-chromosomal genetic diversity and linkage disequilibrium patterns in Native Americans and worldwide populations AMERICAN JOURNAL OF HUMAN BIOLOGY, 24(2), 218 - 218.
Campbell DD,Parra MV,Duque C,Gallego N,Franco L,Tandon A,Hünemeier T,Bortolini C,Villegas A,Bedoya G,McCarthy MI,Price A,Reich D,Ruiz-Linares A (2012) Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population. PLoS One, 7(4), e33570. 10.1371/journal.pone.0033570.
Scharf J,Yu D,Mathews C,Neale B,Stewart E,Fagerness J,Evans P,Gamazon E,Service S,Osiecki L,Illmann C,Cath D,King R,Dion Y,Sandor P,Barr C,Budman C,Lyon G,Grados M,Singer H,Jankovic J,Gilbert D,Hoekstra P,Heiman G,Tischfield J,State M,Robertson M,Kurlan R,Ophoff R,Gibbs JR,Cookson M,Hardy J,Singleton A,Ruiz-Linares A,Rouleau G,Heutink P,Oostra B,McMahon W,Freimer N,Cox N,Pauls D (2012) Genome-Wide Association Study of Gilles de la Tourette Syndrome NEUROLOGY, 78.
Reich D,Patterson N,Campbell D,Tandon A,Mazieres S,Ray N,Parra MV,Rojas W,Duque C,Mesa N,Garc�a LF,Triana O,Blair S,Maestre A,Dib JC,Bravi CM,Bailliet G,Corach D,H�nemeier T,Bortolini MC,Salzano FM,Petzl-Erler ML,Acu�a-Alonzo V,Aguilar-Salinas C,Canizales-Quinteros S,Tusi�-Luna T,Riba L,Rodr�guez-Cruz M,Lopez-Alarc�n M,Coral-Vazquez R,Canto-Cetina T,Silva-Zolezzi I,Fernandez-Lopez JC,Contreras AV,Jimenez-Sanchez G,G�mez-V�zquez MJ,Molina J,Carracedo A,Salas A,Gallo C,Poletti G,Witonsky DB,Alkorta-Aranburu G,Sukernik RI,Osipova L,Fedorova SA,Vasquez R,Villena M,Moreau C,Barrantes R,Pauls D,Excoffier L,Bedoya G,Rothhammer F,Dugoujon JM,Larrouy G,Klitz W,Labuda D,Kidd J,Kidd K,Di Rienzo A,Freimer NB,Price AL,Ruiz-Linares A (2012) Reconstructing Native American population history Nature, 488, 370 - 374. 10.1038/nature11258.
Cuartas Arias JM,Palacio Acosta CA,Valencia JG,Montoya GJ,Arango Viana JC,Nieto OC,Flórez AF,Camarena Medellin BE,Montoya WR,Lopez Jaramillo CA,Achury JG,Fuentes CC,Berrio GB,Ruiz-Linares A (2011) Exploring epistasis in candidate genes for antisocial personality disorder. Psychiatr Genet, 21(3), 115 - 124. 10.1097/YPG.0b013e3283437175.
Amorim CE,Wang S,Marrero AR,Salzano FM,Ruiz-Linares A,Bortolini MC (2011) X-chromosomal genetic diversity and linkage disequilibrium patterns in Amerindians and non-Amerindian populations. Am J Hum Biol, 23(3), 299 - 304. 10.1002/ajhb.21110.
Rojas W,Parra MV,Campo O,Caro MA,Lopera JG,Arias W,Duque C,Naranjo A,García J,Vergara C,Lopera J,Hernandez E,Valencia A,Caicedo Y,Cuartas M,Gutiérrez J,López S,Ruiz-Linares A,Bedoya G (2010) Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers. Am J Phys Anthropol, 143(1), 13 - 20. 10.1002/ajpa.21270.
Hünemeier T,Ruiz-Linares A,Silveira A,Paixão-Côrtes VR,Salzano FM,Bortolini MC (2010) Brief communication: Population data support the adaptive nature of HACNS1 sapiens/neandertal-chimpanzee differences in a limb expression domain. Am J Phys Anthropol, 143(3), 478 - 481. 10.1002/ajpa.21378.
Kremeyer B,Lopera F,Cox JJ,Momin A,Rugiero F,Marsh S,Woods CG,Jones NG,Paterson KJ,Fricker FR,Villegas A,Acosta N,Pineda-Trujillo NG,Ramírez JD,Zea J,Burley MW,Bedoya G,Bennett DL,Wood JN,Ruiz-Linares A (2010) A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Neuron, 66(5), 671 - 680. 10.1016/j.neuron.2010.04.030.
Yang NN,Mazières S,Bravi C,Ray N,Wang S,Burley MW,Bedoya G,Rojas W,Parra MV,Molina JA,Gallo C,Poletti G,Hill K,Hurtado AM,Petzl-Erler ML,Tsuneto LT,Klitz W,Barrantes R,Llop E,Rothhammer F,Labuda D,Salzano FM,Bortolini MC,Excoffier L,Dugoujon JM,Ruiz-Linares A (2010) Contrasting patterns of nuclear and mtDNA diversity in Native American populations. Ann Hum Genet, 74(6), 525 - 538. 10.1111/j.1469-1809.2010.00608.x.
Kremeyer B,García J,Müller H,Burley MW,Herzberg I,Parra MV,Duque C,Vega J,Montoya P,López MC,Bedoya G,Reus V,Palacio C,López C,Ospina-Duque J,Freimer NB,Ruiz-Linares A (2010) Genome-wide linkage scan of bipolar disorder in a Colombian population isolate replicates Loci on chromosomes 7p21-22, 1p31, 16p12 and 21q21-22 and identifies a novel locus on chromosome 12q. Hum Hered, 70(4), 255 - 268. 10.1159/000320914.
Herzberg I,Valencia-Duarte AV,Kay VA,White DJ,Müller H,Rivas IC,Mesa SC,Cuartas M,García J,Bedoya G,Cornejo W,Ruiz-Linares A,Kremeyer B (2010) Association of DRD2 variants and Gilles de la Tourette syndrome in a family-based sample from a South American population isolate. Psychiatr Genet, 20(4), 179 - 183. 10.1097/YPG.0b013e32833a215a.
Ray N,Wegmann D,Fagundes NJ,Wang S,Ruiz-Linares A,Excoffier L (2010) A statistical evaluation of models for the initial settlement of the american continent emphasizes the importance of gene flow with Asia. Mol Biol Evol, 27(2), 337 - 345. 10.1093/molbev/msp238.
Wang S,Bedoya G,Labuda D,Ruiz-Linares A (2010) Brief communication: patterns of linkage disequilibrium and haplotype diversity at Xq13 in six Native American populations. Am J Phys Anthropol, 142(3), 476 - 480. 10.1002/ajpa.21234.
Jasinska AJ,Service S,Jawaheer D,DeYoung J,Levinson M,Zhang Z,Kremeyer B,Muller H,Aldana I,Garcia J,Restrepo G,Lopez C,Palacio C,Duque C,Parra M,Vega J,Ortiz D,Bedoya G,Mathews C,Davanzo P,Fournier E,Bejarano J,Ramirez M,Araya Ortiz C,Araya X,Molina J,Sabatti C,Reus V,Ospina J,Macaya G,Ruiz-Linares A,Freimer NB (2009) A narrow and highly significant linkage signal for severe bipolar disorder in the chromosome 5q33 region in Latin American pedigrees. Am J Med Genet B Neuropsychiatr Genet, 150B(7), 998 - 1006. 10.1002/ajmg.b.30956.
Bourgeois S,Yotova V,Wang S,Bourtoumieu S,Moreau C,Michalski R,Moisan JP,Hill K,Hurtado AM,Ruiz-Linares A,Labuda D (2009) X-chromosome lineages and the settlement of the Americas. Am J Phys Anthropol, 140(3), 417 - 428. 10.1002/ajpa.21084.
Vergara C,Caraballo L,Mercado D,Jimenez S,Rojas W,Rafaels N,Hand T,Campbell M,Tsai YJ,Gao L,Duque C,Lopez S,Bedoya G,Ruiz-Linares A,Barnes KC (2009) African ancestry is associated with risk of asthma and high total serum IgE in a population from the Caribbean Coast of Colombia. Hum Genet, 125(5-6), 565 - 579. 10.1007/s00439-009-0649-2.
Kremeyer B,García J,Kymäläinen H,Wratten N,Restrepo G,Palacio C,Miranda AL,López C,Restrepo M,Bedoya G,Brzustowicz LM,Ospina-Duque J,Arbeláez MP,Ruiz-Linares A (2009) Evidence for a role of the NOS1AP (CAPON) gene in schizophrenia and its clinical dimensions: an association study in a South American population isolate. Hum Hered, 67(3), 163 - 173. 10.1159/000181154.
Florez JC,Price AL,Campbell D,Riba L,Parra MV,Yu F,Duque C,Saxena R,Gallego N,Tello-Ruiz M,Franco L,Rodríguez-Torres M,Villegas A,Bedoya G,Aguilar-Salinas CA,Tusié-Luna MT,Ruiz-Linares A,Reich D (2009) Strong association of socioeconomic status with genetic ancestry in Latinos: implications for admixture studies of type 2 diabetes. Diabetologia, 52(8), 1528 - 1536. 10.1007/s00125-009-1412-x.
Price AL,Butler J,Patterson N,Capelli C,Pascali VL,Scarnicci F,Ruiz-Linares A,Groop L,Saetta AA,Korkolopoulou P,Seligsohn U,Waliszewska A,Schirmer C,Ardlie K,Ramos A,Nemesh J,Arbeitman L,Goldstein DB,Reich D,Hirschhorn JN (2008) Discerning the ancestry of European Americans in genetic association studies. PLoS Genet, 4(1), e236. 10.1371/journal.pgen.0030236.
Nikali K,Vanegas JJ,Burley MW,Martinez J,Lopez LM,Bedoya G,Wrong OM,Povey S,Unwin RJ,Ruiz-Linares A (2008) Extensive founder effect for distal renal tubular acidosis (dRTA) with sensorineural deafness in an isolated South American population. Am J Med Genet A, 146A(20), 2709 - 2712. 10.1002/ajmg.a.32495.
Wang S,Ray N,Rojas W,Parra MV,Bedoya G,Gallo C,Poletti G,Mazzotti G,Hill K,Hurtado AM,Camrena B,Nicolini H,Klitz W,Barrantes R,Molina JA,Freimer NB,Bortolini MC,Salzano FM,Petzl-Erler ML,Tsuneto LT,Dipierri JE,Alfaro EL,Bailliet G,Bianchi NO,Llop E,Rothhammer F,Excoffier L,Ruiz-Linares A (2008) Geographic patterns of genome admixture in Latin American Mestizos. PLoS Genet, 4(3), e1000037. 10.1371/journal.pgen.1000037.
Price AL,Patterson N,Yu F,Cox DR,Waliszewska A,McDonald GJ,Tandon A,Schirmer C,Neubauer J,Bedoya G,Duque C,Villegas A,Bortolini MC,Salzano FM,Gallo C,Mazzotti G,Tello-Ruiz M,Riba L,Aguilar-Salinas CA,Canizales-Quinteros S,Menjivar M,Klitz W,Henderson B,Haiman CA,Winkler C,Tusie-Luna T,Ruiz-Linares A,Reich D (2007) A genomewide admixture map for Latino populations. The American Journal of Human Genetics, 80, 1024 - 1036. 10.1086/518313.
Marrero AR,Bravi C,Stuart S,Long JC,Pereira das Neves Leite F,Kommers T,Carvalho CM,Pena SD,Ruiz-Linares A,Salzano FM,Cátira Bortolini M (2007) Pre- and post-Columbian gene and cultural continuity: the case of the Gaucho from southern Brazil. Hum Hered, 64(3), 160 - 171. 10.1159/000102989.
Marrero AR,Silva-Junior WA,Bravi CM,Hutz MH,Petzl-Erler ML,Ruiz-Linares A,Salzano FM,Bortolini MC (2007) Demographic and evolutionary trajectories of the Guarani and Kaingang natives of Brazil. Am J Phys Anthropol, 132(2), 301 - 310. 10.1002/ajpa.20515.
Wang S,Lewis CM,Jakobsson M,Ramachandran S,Ray N,Bedoya G,Rojas W,Parra MV,Molina JA,Gallo C,Mazzotti G,Poletti G,Hill K,Hurtado AM,Labuda D,Klitz W,Barrantes R,Bortolini MC,Salzano FM,Petzl-Erler ML,Tsuneto LT,Llop E,Rothhammer F,Excoffier L,Feldman MW,Rosenberg NA,Ruiz-Linares A (2007) Genetic variation and population structure in native Americans. PLoS Genet, 3(11), e185. 10.1371/journal.pgen.0030185.
Kremeyer B,Herzberg I,Garcia J,Kerr E,Duque C,Parra V,Vega J,Lopez C,Palacio C,Bedoya G,Ospina J,Ruiz-Linares A (2006) Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate. Am J Med Genet B Neuropsychiatr Genet, 141B(5), 435 - 439. 10.1002/ajmg.b.30354.
Pineda-Trujillo N,Apergi M,Moreno S,Arias W,Lesage S,Franco A,Sepulveda-Falla D,Cano D,Buritica O,Pineda D,Uribe CS,de Yebenes JG,Lees AJ,Brice A,Bedoya G,Lopera F,Ruiz-Linares A (2006) A genetic cluster of early onset Parkinson's disease in a Colombian population American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141(8), 885 - 889. 10.1002/ajmg.b.30375.
Glatt CE,Wahner AD,White DJ,Ruiz-Linares A,Ritz B (2006) Gain-of-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in women. Hum Mol Genet, 15(2), 299 - 305. 10.1093/hmg/ddi445.
Miranda A,García J,López C,Gordon D,Palacio C,Restrepo G,Ortiz J,Montoya G,Cardeño C,Calle J,López M,Campo O,Bedoya G,Ruiz-Linares A,Ospina-Duque J (2006) Putative association of the carboxy-terminal PDZ ligand of neuronal nitric oxide synthase gene (CAPON) with schizophrenia in a Colombian population. Schizophr Res, 82(2-3), 283 - 285. 10.1016/j.schres.2005.10.018.
Service S,DeYoung J,Karayiorgou M,Roos JL,Pretorious H,Bedoya G,Ospina J,Ruiz-Linares A,Macedo A,Palha JA,Heutink P,Aulchenko Y,Oostra B,van Duijn C,Jarvelin M-J,Varilo T,Peddle L,Rahman P,Piras G,Monne M,Murray S,Galver L,Peltonen L,Sabatti C,Collins A,Freimer N (2006) Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies Nature Genetics, 38(5), 556 - 560. 10.1038/ng1770.
Bedoya G,Montoya P,Garcia J,Soto I,Bourgeois S,Carvajal L,Labuda V,Alvarez J,Ospina P,Hedrick W,Ruiz-Linares A (2006) Admixture dynamics in Hispanics: a shift in the nuclear genetic ancestry of a South American population isolate Proceedings of the National Academy of Sciences of the United States of America, 103(19), 7234 - 7239. 10.1073/pnas.0508716103.
Choo KE,Nicoli TK,Bruce LJ,Tanner MJ,Ruiz-Linares A,Wrong OM (2006) Recessive distal renal tubular acidosis in Sarawak caused by AE1 mutations. Pediatr Nephrol, 21(2), 212 - 217. 10.1007/s00467-005-2061-z.
Torres MM,Bravi CM,Bortolini MC,Duque C,Callegari-Jacques S,Ortiz D,Bedoya G,Groot de Restrepo H,Ruiz-Linares A (2006) A revertant of the major founder Native American haplogroup C common in populations from northern South America. Am J Hum Biol, 18(1), 59 - 65. 10.1002/ajhb.20461.
Pereira TV,Salzano FM,Mostowska A,Trzeciak WH,Ruiz-Linares A,Chies JA,Saavedra C,Nagamachi C,Hurtado AM,Hill K,Castro-de-Guerra D,Silva-Júnior WA,Bortolini MC (2006) Natural selection and molecular evolution in primate PAX9 gene, a major determinant of tooth development. Proc Natl Acad Sci U S A, 103(15), 5676 - 5681. 10.1073/pnas.0509562103.
Herzberg I,Jasinska A,García J,Jawaheer D,Service S,Kremeyer B,Duque C,Parra MV,Vega J,Ortiz D,Carvajal L,Polanco G,Restrepo GJ,López C,Palacio C,Levinson M,Aldana I,Mathews C,Davanzo P,Molina J,Fournier E,Bejarano J,Ramírez M,Ortiz CA,Araya X,Sabatti C,Reus V,Macaya G,Bedoya G,Ospina J,Freimer N,Ruiz-Linares A (2006) Convergent linkage evidence from two Latin-American population isolates supports the presence of a susceptibility locus for bipolar disorder in 5q31-34. Hum Mol Genet, 15(21), 3146 - 3153. 10.1093/hmg/ddl254.
Marrero AR,Das Neves Leite FP,De Almeida Carvalho B,Peres LM,Kommers TC,Da Cruz IM,Salzano FM,Ruiz-Linares A,Da Silva Júnior WA,Bortolini MC (2005) Heterogeneity of the genome ancestry of individuals classified as White in the state of Rio Grande do Sul, Brazil. Am J Hum Biol, 17(4), 496 - 506. 10.1002/ajhb.20404.
Pineda-Trujillo N,Carrizosa J,Cornejo W,Arias W,Franco C,Cabrera C,Bedoya G,Ruíz-Linares A (2005) A novel SCN1A mutation associated with severe GEFS+ in a large South American pedigree. Epilepsy, 14, 123 - 128.
Pineda-Trujillo N,Cornejo W,Carrizosa J,Wheeler RB,Munera S,Valencia A,Agudelo-Arango J,Cogollo A,Anderson G,Bedoya G,Mole SE,Ruiz-Linares A (2005) A CLN5 mutation causing an atypical neuronal ceroid lipofuscinosis of juvenile onset Neurology, 64(4), 740 - 742.
Bortolini MC,Thomas MG,Chikhi L,Ruiz-Linares A (2004) Ribeiro's typology genomes and Spanish colonialism Genetics and Molecular Biology, 27(1), 1 - 8.
Bortolini MC,Thomas MG,Chikhi L,Aguilar JA,Castro-De-Guerra D,Salzano FM,Ruiz-Linare A (2004) Ribeiro’s typology, genomes, and Spanish colonialism, as viewed from Gran Canaria and Colombia Genetics and Molecular Biology, 27(1), 1 - 8. 10.1590/S1415-47572004000100001.
Ruiz-Linares A (2004) Juvenile Parkinson's Disease and the C212Y mutation of parkin Archives of Neurology, 61(3), 444 - 444.
Carvajal-Carmona LG,Bermudez N,Olivera-Angel M,Estrada L,Ossa J,Bedoya G,Ruiz Linares A (2003) Abundant mtDNA diversity and ancestral admixture in Colombian criollo cattle (Bos taurus) Genetics, 165, 1457 - 1463.
Bortolini MC,Salzano FM,Thomas MG,Bau CHD,Layrisse Z,Petzl-Erler ML,Tsuneto LT,Hill K,Hurtado AM,Castro-de-Guerra D,Torres MM,Groot H,Michalski R,Nymadawa P,Bedoya G,Bradman N,Labuda D,Ruiz-Linares A (2003) Y-chromosome evidence for differing ancient demographic histories in the Americas The American Journal of Human Genetics, 73, 524 - 539. 10.1086/377588.
Carvajal-Carmona LG,Ophoff R,Jaana Hartiala SS,Molina J,Leon P,Ospina J,Bedoya G,Freimer N,Ruiz-Linares A (2003) Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica Human Genetics, 112, 534 - 541.
Bortolini MC,Salzano FM,Bau CH,Layrisse Z,Petzl-Erler ML,Tsuneto LT,Hill K,Hurtado AM,Castro-De-Guerra D,Bedoya G,Ruiz-Linares A (2002) Y-chromosome biallelic polymorphisms and Native American population structure. Ann Hum Genet, 66(Pt 4), 255 - 259. 10.1017/S0003480002001148.

Biography