PHP Code

Using the PHP code extracts allows Academic Staff Profiles to be displayed in a number of different styles including the tabbed format shown below - the data is provided dynamically from the IRIS application, while maintaning the consistent look and feel of your site.

Prof Alexander Seifalian

  • Telephone:

    020 7830 2901

  • Extension:

    020 7830 2901

  • Email:

    a.seifalian@ucl.ac.uk

  • Webpage:

    http://www.ucl.ac.uk/nanomed

  • Address:

    UCL Centre for Nanotechnology & Regenerative Medicine 9th Floor, Royal Free Campus,
    Pond Street,
    London,
    NW3 2QG

  • Appointments:

    Professor of Nanotechnology and Regenerative Medicine, Research Department of General Surgery, Div of Surgery & Interventional Sci

Research Summary

1. Development of Nanomaterial.
2. Development of cardiovascular implant.
3. Development of nanofluorescence particle including quantum dots for localisation and treatment of cancer.
4. Stem cells for development of organ using tissue engineering.
5. Development of organ using biodegradation nanomaterials and stem cells, including liver, intestine.
6. Hepatic microcirculation and oxygenation using optical technique.
7. Ischemia reperfusion injury and preconditioning.

Research Activities

  • Cardiovascular implant
  • Colorectal Cancer Research Programme
  • Experimental cancer therapeutics- ETAR antagonism, colorectal cancer
  • Minimally invasive approach in diagnosis and treatment of Breast Cancer
  • Polymer nanocomposites for Novel Tissue Engineering Scaffolds
  • Regenerative medicine
  • Transcatheter Heart Valve
  • biomaterial
  • hepatobiliary
  • nanomaterial
  • nanotechnology
  • quantum dots
  • stem cells
  • tissue engineering

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Sedaghati T,Jell G,Mosahebi A,Butler P,Seifalian AM (2013) Design of novel nanocomposite nerve conduits BRITISH JOURNAL OF SURGERY, 100, 74 - 74.
  2. Naderi N,Madani SY,Ferguson E,Mosahebi A,Seifalian AM (2013) Carbon nanotubes in the diagnosis and treatment of malignant melanoma. Anticancer Agents Med Chem, 13(1), 171 - 185.
  3. Sedaghati T,Jell G,Mosahebi A,Butler P,Seifalian AM (2013) Design of novel nanocomposite nerve conduits BRITISH JOURNAL OF SURGERY, 100, 6 - 6.
  4. Tan A,Rafiei Y,de Mel A,Rajadas J,Alavijeh MS,Seifalian AM (2013) Next generation coronary stent incorporating nanotechnology BRITISH JOURNAL OF SURGERY, 100, 29 - 29.
  5. Ahmed M,Punshon G,Darbyshire A,Seifalian AM (2013) Effects of sterilization treatments on bulk and surface properties of nanocomposite biomaterials. J Biomed Mater Res B Appl Biomater. 10.1002/jbm.32928.
  6. G N,Tan A,Farhatnia Y,Rajadas J,Hamblin MR,Khaw PT,Seifalian AM (2013) Channelrhodopsins: visual regeneration and neural activation by a light switch. N Biotechnol. 10.1016/j.nbt.2013.04.007.
  7. Shirvan MK,Alamdari DH,Darabi M,Ghanadi A,Rahimi H,Seifalian A (2013) A novel cell therapy for stress urinary incontinence, short-term outcome BJU INTERNATIONAL, 111, 17 - 18.
  8. Oseni AO,Butler PE,Seifalian AM (2013) The application of POSS nanostructures in cartilage tissue engineering: the chondrocyte response to nanoscale geometry. J Tissue Eng Regen Med. 10.1002/term.1693.
  9. Kerstein RL,Sedaghati T,Seifalian AM,Kang N (2013) Effect of human urine on the tensile strength of sutures used for hypospadias surgery. J Plast Reconstr Aesthet Surg, 66(6), 835 - 838. 10.1016/j.bjps.2013.02.006.
  10. Cittadella G,de Mel A,Dee R,De Coppi P,Seifalian AM (2013) Arterial tissue regeneration for pediatric applications: inspiration from up-to-date tissue-engineered vascular bypass grafts. Artif Organs, 37(5), 423 - 434. 10.1111/aor.12022.
  11. Brakmane G,Madani SY,Seifalian A (2013) Cancer Antibody Enhanced Real Time Imaging Cell Probes - a Novel Theranostic Tool using Polymer Linked Carbon Nanotubes and Quantum Dots. Anticancer Agents Med Chem, 13(5), 821 - 832.
  12. Yildirimer L,Seifalian AM,Butler PE (2013) Surface and mechanical analysis of explanted Poly Implant Prosthèse silicone breast implants. Br J Surg, 100(6), 761 - 767. 10.1002/bjs.9094.
  13. Oseni AO,Butler PE,Seifalian AM (2013) Rapid production of autologous fibrin hydrogels for cellular encapsulation in organ regeneration. Methods Mol Biol, 1001, 145 - 152. 10.1007/978-1-62703-363-3_12.
  14. Madani SY,Shabani F,Dwek MV,Seifalian AM (2013) Conjugation of quantum dots on carbon nanotubes for medical diagnosis and treatment. Int J Nanomedicine, 8, 941 - 950. 10.2147/IJN.S36416.
  15. Mozafari M,Moztarzadeh F,Seifalian AM,Tayebi L (2013) Self-assembly of PbS hollow sphere quantum dots via gas-bubble technique for early cancer diagnosis JOURNAL OF LUMINESCENCE, 133, 188 - 193. 10.1016/j.jlumin.2011.12.054.
  16. Goh D,Tan A,Farhatnia Y,Rajadas J,Alavijeh MS,Seifalian AM (2013) Nanotechnology-based gene-eluting stents. Mol Pharm, 10(4), 1279 - 1298. 10.1021/mp3006616.
  17. Oseni AO,Butler PE,Seifalian AM (2013) Nasal Reconstruction Using Tissue Engineered Constructs: An Update. Ann Plast Surg. 10.1097/SAP.0b013e31824f20a3.
  18. Tan A,Farhatnia Y,de Mel A,Rajadas J,Alavijeh MS,Seifalian AM (2013) Inception to actualization: next generation coronary stent coatings incorporating nanotechnology. J Biotechnol, 164(1), 151 - 170. 10.1016/j.jbiotec.2013.01.020.
  19. Shoae-Hassani A,Mortazavi-Tabatabaei SA,Sharif S,Seifalian AM,Azimi A,Samadikuchaksaraei A,Verdi J (2013) Differentiation of human endometrial stem cells into urothelial cells on a three-dimensional nanofibrous silk-collagen scaffold: an autologous cell resource for reconstruction of the urinary bladder wall. J Tissue Eng Regen Med. 10.1002/term.1632.
  20. Farhatnia Y,Tan A,Motiwala A,Cousins BG,Seifalian AM (2013) Evolution of covered stents in the contemporary era: clinical application, materials and manufacturing strategies using nanotechnology. Biotechnol Adv. 10.1016/j.biotechadv.2012.12.010.
  21. Naghavi N,de Mel A,Alavijeh OS,Cousins BG,Seifalian AM (2013) Nitric oxide donors for cardiovascular implant applications. Small, 9(1), 22 - 35. 10.1002/smll.201200458.
  22. Oseni AO,Butler PE,Seifalian AM (2013) Optimization of chondrocyte isolation and characterization for large-scale cartilage tissue engineering. J Surg Res, 181(1), 41 - 48. 10.1016/j.jss.2012.05.087.
  23. Tan A,Rajadas J,Seifalian AM (2013) Exosomes as nano-theranostic delivery platforms for gene therapy. Adv Drug Deliv Rev, 65(3), 357 - 367. 10.1016/j.addr.2012.06.014.
  24. Shirvan MK,Alamdari DH,Mahboub MD,Ghanadi A,Rahimi HR,Seifalian AM (2013) A novel cell therapy for stress urinary incontinence, short-term outcome. Neurourol Urodyn, 32(4), 377 - 382. 10.1002/nau.22301.
  25. Shukur A,Rizvi SB,Whitehead D,Seifalian A,Azzawi M (2013) Altered sensitivity to nitric oxide donors, induced by intravascular infusion of quantum dots, in murine mesenteric arteries. Nanomedicine, 9(4), 532 - 539. 10.1016/j.nano.2012.10.004.
  26. Teoh GZ,Crowley C,Birchall M,Seifalian AM (2013) The development of resorbable nanocomposite trachea and bronchi scaffolds for paediatric applications: A tissue engineering solution to organ transplantation BRITISH JOURNAL OF SURGERY, 100, 44 - 44.
  27. Kanoria S,Glantzounis G,Quaglia A,Dinesh S,Fusai G,Davidson BR,Seifalian AM (2012) Remote preconditioning improves hepatic oxygenation after ischaemia reperfusion injury. Transpl Int, 25(7), 783 - 791. 10.1111/j.1432-2277.2012.01481.x.
  28. Nayyer L,Patel KH,Esmaeili A,Rippel RA,Birchall M,Oʼtoole G,Butler PE,Seifalian AM (2012) Tissue engineering: revolution and challenge in auricular cartilage reconstruction. Plast Reconstr Surg, 129(5), 1123 - 1137. 10.1097/PRS.0b013e31824a2c1c.
  29. de Mel A,Chaloupka K,Malam Y,Darbyshire A,Cousins B,Seifalian AM (2012) A silver nanocomposite biomaterial for blood-contacting implants. J Biomed Mater Res A, 100(9), 2348 - 2357. 10.1002/jbm.a.34177.
  30. Rahmani, B ,Tzamtzis S,Ghanbari H,Burriesci G,Seifalian AM (2012) A novel aortic valve prosthesis made of a new nanocomposite polymer: hydrodynamic assessment. Cardiology, 121(2), 132 - 133.
  31. López-Dávila V,Seifalian AM,Loizidou M (2012) Organic nanocarriers for cancer drug delivery. Curr Opin Pharmacol, 12(4), 414 - 419. 10.1016/j.coph.2012.02.011.
  32. Abu-Amara M,Yang SY,Quaglia A,Rowley P,Tapuria N,Fuller B,Davidson B,Seifalian A (2012) The hepatic soluble guanylyl cyclase-cyclic guanosine monophosphate pathway mediates the protection of remote ischemic preconditioning on the microcirculation in liver ischemia-reperfusion injury. Transplantation, 93(9), 880 - 886. 10.1097/TP.0b013e31824cd59d.
  33. Madani SY,Tan A,Dwek M,Seifalian AM (2012) Functionalization of single-walled carbon nanotubes and their binding to cancer cells. Int J Nanomedicine, 7, 905 - 914. 10.2147/IJN.S25035.
  34. Rippel RA,Ghanbari H,Seifalian AM (2012) Tissue-engineered heart valve: future of cardiac surgery. World J Surg, 36(7), 1581 - 1591. 10.1007/s00268-012-1535-y.
  35. Rahmani B,Tzamtzis S,Ghanbari H,Burriesci G,Seifalian AM (2012) Manufacturing and hydrodynamic assessment of a novel aortic valve made of a new nanocomposite polymer. J Biomech, 45(7), 1205 - 1211. 10.1016/j.jbiomech.2012.01.046.
  36. Abu-Amara M,Yang SY,Seifalian A,Davidson B,Fuller B (2012) The nitric oxide pathway--evidence and mechanisms for protection against liver ischaemia reperfusion injury. Liver Int, 32(4), 531 - 543. 10.1111/j.1478-3231.2012.02755.x.
  37. Totonelli G,Maghsoudlou P,Garriboli M,Riegler J,Orlando G,Burns AJ,Sebire NJ,Smith VV,Fishman JM,Ghionzoli M (2012) A rat decellularized small bowel scaffold that preserves villus-crypt architecture for intestinal regeneration Biomaterials, 33(12), 3401 - 3410. 10.1016/j.biomaterials.2012.01.012.
  38. Tapuria N,Junnarkar S,Abu-Amara M,Fuller B,Seifalian AM,Davidson BR (2012) Modulation of microcirculatory changes in the late phase of hepatic ischaemia-reperfusion injury by remote ischaemic preconditioning. HPB (Oxford), 14(2), 87 - 97. 10.1111/j.1477-2574.2011.00407.x.
  39. Oseni A,Crowley C,Lowdell M,Birchall M,Butler PE,Seifalian AM (2012) Advancing nasal reconstructive surgery: the application of tissue engineering technology. J Tissue Eng Regen Med, 6(10), 757 - 768. 10.1002/term.487.
  40. Madani SY,Tan A,Naderi N,Seifalian AM (2012) Application of OctaAmmonium-POSS functionalized single walled carbon nanotubes for thermal treatment of cancer. J Nanosci Nanotechnol, 12(12), 9018 - 9028.
  41. Rahmani B,Burriesci G,Mullen M,Seifalian A,Tzamtzis S,Yap J (2012) A New Generation Transcatheter Heart Valve with a Novel Nanocomposite Material and Fully Retrievable Design. JACC: Cardiovascular Interventions, 60(17), B34. 10.1016/j.jacc.2012.08.126.
  42. Chipara M,DeHosson JTM,Fierro G,Gonzalez J,Kaptay G,Ali N,Seifalian AM (2012) Selected Peer-Reviewed Articles from the 5th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT 2010) JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 12(6), 4685 - 4687. 10.1166/jnn.2012.4881.
  43. de Mel A,Chaloupka K,Malam Y,Darbyshire A,Cousins BG,Seifalian AM (2012) A silver nanocomposite biomaterial for blood-contacting implants. J Biomed Mater Res A.. 10.1002/jbm.a.34177..
  44. Tan A,Alavijeh MS,Seifalian AM (2012) Next generation stent coatings: convergence of biotechnology and nanotechnology. Trends Biotechnol, 30(8), 406 - 409. 10.1016/j.tibtech.2012.05.004.
  45. Desai M,Bakhshi R,Zhou X,Odlyha M,You Z,Seifalian AM,Hamilton G (2012) A sutureless aortic stent-graft based on a nitinol scaffold bonded to a compliant nanocomposite polymer is durable for 10 years in a simulated in vitro model. J Endovasc Ther, 19(3), 415 - 427. 10.1583/11-3740MR.1.
  46. Tan A,Rajadas J,Seifalian AM (2012) Biochemical engineering nerve conduits using peptide amphiphiles. J Control Release, 163(3), 342 - 352. 10.1016/j.jconrel.2012.08.009.
  47. Ahmed M,Yildirimer L,Khademhosseini A,Seifalian AM (2012) Nanostructured materials for cardiovascular tissue engineering. J Nanosci Nanotechnol, 12(6), 4775 - 4785.
  48. Ghaderi S,Ramesh B,Seifalian AM (2012) Synthesis of mercaptosuccinic acid/MercaptoPolyhedral oligomeric silsesquioxane coated cadmium telluride quantum dots in cell labeling applications. J Nanosci Nanotechnol, 12(6), 4928 - 4935.
  49. Tan A,Madani SY,Rajadas J,Pastorin G,Seifalian AM (2012) Synergistic photothermal ablative effects of functionalizing carbon nanotubes with a POSS-PCU nanocomposite polymer. J Nanobiotechnology, 10, 34. 10.1186/1477-3155-10-34.
  50. Yildirimer L,Thanh NT,Seifalian AM (2012) Skin regeneration scaffolds: a multimodal bottom-up approach. Trends Biotechnol, 30(12), 638 - 648. 10.1016/j.tibtech.2012.08.004.

Qualifications

  • 2003: Doctor of Philosophy, Royal Free University College Medical School
  • 1985: Master of Science, University of London
  • 1982: Bachelor of Science, King's College London

Keywords

  • Biomarker
  • Biomaterials
  • Breast cancer
  • Cancer
  • Cancer targeting
  • Cardiovascular
  • Ischaemia-reperfusion injury
  • Ischaemic preconditioning
  • Liver cancer
  • Liver failure
  • Liver metastases
  • Nanotechnology
  • Optical diagnosis
  • Physiology
  • Stem cells
  • Surgery
  • Tissue engineering
  • Ultrasound diagnosis
  • Vascular growth factors
  • Vascular targeting
  • bypass
  • coronary artery
  • heart valve
  • nanomedicine
  • nanoscience
  • organ
  • skin
  • stent
  • trachea
  • trachea