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Prof Andrew Lees

  • Extension:

    24246

  • Fax:

    020 7278 4993

  • Email:

    andrew.lees@ucl.ac.uk

  • Webpage:

    http://www.ucl.ac.uk/rlweston-inst/Staff-AJL.html

  • Address:

    Reta Lila Weston Institute of Neurological Studies,
    1 Wakefield Street,
    London,
    WC1N 1PJ

  • Appointments:

    Principal Clinical Research Associate, RLW Institute of Neurological Sciences, Institute of Neurology
    Professor of Clinical Neurology and Francis & Francis & Renee Hock Director, Institute of Neurology, Faculty of Brain Sciences

Research Summary

Clinico-pathological correlations of Parkinsons disease and PSP
Experimental therapeutics of Parkinsons disease and PSP
Clinical, functional imaging and neuropsychological study of the dopamine dysregulation syndrome in Parkinsons disease
The development of a bedside test of odour identification to facilitate the differential diagnosis of Parkinson syndromes.
The evaluation of dopamine transporter(DAT)SPECT in tremor disorders
A pathological study of the substantia nigra to determine if l-dopa is neurotoxic
A clinical and radiological study of ephedrone toxicity in the Ukraine.
MR and stereological pathological study of the subthalamic nucleus in PSP
The development of a biomarker for PSP ( cerebrospinal fluid four repeat tau assay)
Identification of susceptibility genes for PSP and Parkinsons disease
Associate Director of Dendron designed to facilitate clinical trials in Parkinsons disease and related neurodegenerative disorders in the UK

Research Activities

  • A systematic investigation into the pathogenesis and course of Parkinson's syndrome
  • Genetic Influences on Treatment response in Moveme
  • Inflammatory conditions of the gastrointestinal tract
  • Neurological disease
  • Parkinsons disease and related Movement Disorders

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Magdalinou NK,Ling H,Smith JDS,Schott JM,Watkins LD,Lees AJ (2013) Normal pressure hydrocephalus or progressive supranuclear palsy? A clinicopathological case series Journal of Neurology, 260(4), 1009 - 1013.
  2. Petrovic IN,Martin-Bastida A,Massey L,Ling H,O'Sullivan SS,Williams DR,Holton JL,Revesz T,Ironside JW,Lees AJ,Silveira-Moriyama L (2013) MM2 subtype of sporadic Creutzfeldt-Jakob disease may underlie the clinical presentation of progressive supranuclear palsy. J Neurol, 260(4), 1031 - 1036. 10.1007/s00415-012-6752-7.
  3. Ahmed Z,Asi YT,Lees AJ,Revesz T,Holton JL (2013) Identification and quantification of oligodendrocyte precursor cells in multiple system atrophy, progressive supranuclear palsy and parkinson's disease Brain Pathology, 23(3), 263 - 273.
  4. Rajan S,Bandopadhyay R,Kingsbury A,Ayling H,Sterlacci W,Poewe W,Maier H,Ezquerro M-TH,Lees AJ,Revesz T,Silveira-Moriyama L (2013) Using the anterior olfactory nucleus to study Lewy pathology in olfactory structures NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 39, 49 - 50.
  5. Asi YT,Ling H,Ahmed Z,Lees AJ,Revesz T,Holton JL (2013) Cognitive impairment in multiple system atrophy: a clinico-pathological study NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 39, 36 - 36.
  6. Doherty KM,Silveira-Moriyama L,Parkkinen L,Healy DG,Farrell M,Mencacci NE,Ahmed Z,Brett FM,Hardy J,Quinn N,Counihan TJ,Lynch T,Fox ZV,Revesz T,Lees AJ,Holton JL (2013) Parkin disease - a clinicopathological entity? NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 39, 11 - 12.
  7. Kiely AP,Asi YT,Kara E,Limousin P,Ling H,Lewis P,Proukakis C,Quinn N,Lees AJ,Hardy J,Revesz T,Houlden H,Holton JL (2013) Synucleinopathy with a G51D a-synuclein mutation: a neuropathological and genetic study NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 39, 39 - 40.
  8. Averbeck BB,Djamshidian A,O'Sullivan SS,Housden CR,Roiser JP,Lees AJ (2013) Uncertainty about mapping future actions into rewards may underlie performance on multiple measures of impulsivity in behavioral addiction: Evidence from Parkinson's disease. Behav Neurosci, 127(2), 245 - 255. 10.1037/a0032079.
  9. Ling H,Petrovic IN,Lang AE,Lees AJ (2013) Reply to letter: Multiple system atrophy-parkinsonism with slow progression and prolonged survival: a diagnostic catch. Mov Disord, 28(3), 408. 10.1002/mds.25288.
  10. Compta Y,Revesz T,Lees AJ (2013) The more cortical amyloid-β, the more postural instability in parkinson's disease: More grist to the mill for a link between walking, falling, and remembering? Movement Disorders, 28(3), 263 - 264.
  11. Munhoz RP,Teive HA,Eleftherohorinou H,Coin LJ,Lees AJ,Silveira-Moriyama L (2013) Demographic and motor features associated with the occurrence of neuropsychiatric and sleep complications of Parkinson's disease. J Neurol Neurosurg Psychiatry. 10.1136/jnnp-2012-304440.
  12. Doherty KM,Davagnanam I,Molloy S,Silveira-Moriyama L,Lees AJ (2013) Pisa syndrome in Parkinson's disease: a mobile or fixed deformity? J Neurol Neurosurg Psychiatry. 10.1136/jnnp-2012-304700.
  13. Silveira-Moriyama L,Gardiner AR,Meyer E,King MD,Smith M,Rakshi K,Parker A,Mallick AA,Brown R,Vassallo G,Jardine PE,Guerreiro MM,Lees AJ,Houlden H,Kurian MA (2013) Clinical features of childhood-onset paroxysmal kinesigenic dyskinesia with PRRT2 gene mutations Developmental Medicine and Child Neurology, 55(4), 327 - 334.
  14. Politis M,Loane C,Wu K,O'Sullivan SS,Woodhead Z,Kiferle L,Lawrence AD,Lees AJ,Piccini P (2013) Neural response to visual sexual cues in dopamine treatment-linked hypersexuality in Parkinson's disease. Brain, 136(Pt 2), 400 - 411. 10.1093/brain/aws326.
  15. Rajan S,Parsons L,Lees AJ,Silveira-Moriyama L (2013) Availability of olfactory bulb: experience from a British Brain Bank. Arq Neuropsiquiatr, 71(2), 110 - 112.
  16. Politis M,Loane C,Wu K,O'Sullivan SS,Woodhead Z,Kiferle L,Lawrence AD,Lees AJ,Piccini P (2013) Neural response to visual sexual cues in dopamine treatment-linked hypersexuality in Parkinson's disease Brain, 136(2), 400 - 411.
  17. Aviles-Olmos I,Limousin P,Lees A,Foltynie T (2013) Parkinson's disease, insulin resistance and novel agents of neuroprotection. Brain, 136(Pt 2), 374 - 384. 10.1093/brain/aws009.
  18. Duran R,Mencacci NE,Angeli AV,Shoai M,Deas E,Houlden H,Mehta A,Hughes D,Cox TM,Deegan P,Schapira AH,Lees AJ,Limousin P,Jarman PR,Bhatia KP,Wood NW,Hardy J,Foltynie T (2013) The glucocerobrosidase E326K variant predisposes to Parkinson's disease, but does not cause Gaucher's disease Movement Disorders, 28(2), 232 - 236.
  19. Selikhova M,Kempster PA,Revesz T,Holton JL,Lees AJ (2013) Neuropathological findings in benign tremulous Parkinsonism Movement Disorders, 28(2), 145 - 152.
  20. Rajan S,Parsons L,Lees AJ,Silveira-Moriyama L (2013) Availability of olfactory bulb: Experience from a british Brain Bank | Disponibilidade de bulbos olfatórios em um banco de cérebro britânico: A experiência do Square Brain Bank Arquivos de Neuro-Psiquiatria, 71(2), 110 - 112.
  21. Kiely AP,Asi YT,Kara E,Limousin P,Ling H,Lewis P,Proukakis C,Quinn N,Lees AJ,Hardy J,Revesz T,Houlden H,Holton JL (2013) α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy? Acta Neuropathologica, 1 - 17.
  22. Djamshidian A,Sanotsky Y,Matviyenko Y,O'Sullivan SS,Sharman S,Selikhova M,Fedoryshyn L,Filts Y,Bearn J,Lees AJ,Averbeck BB (2013) Increased reflection impulsivity in patients with ephedrone-induced Parkinsonism. Addiction, 108(4), 771 - 779. 10.1111/add.12080.
  23. Silveira-Moriyama L,Gardiner AR,Meyer E,King MD,Smith M,Rakshi K,Parker A,Mallick AA,Brown R,Vassallo G,Jardine PE,Guerreiro MM,Lees AJ,Houlden H,Kurian MA (2013) Clinical features of childhood-onset paroxysmal kinesigenic dyskinesia with PRRT2 gene mutations Developmental Medicine and Child Neurology.
  24. Vale TC,Glass PG,Lees A,Cardoso F (2013) Gowers' Queen Square Case Notes on Chorea: A 21st Century Re-Appraisal EUROPEAN NEUROLOGY, 69(1), 48 - 52. 10.1159/000343628.
  25. Pearce JMS,Lees AJ (2013) Yorkshire's influence on the foundation of British Neurology Journal of Neurology, Neurosurgery and Psychiatry, 84(1), 6 - 9.
  26. Selikhova M,Kempster PA,Revesz T,Holton JL,Lees AJ (2013) Neuropathological findings in benign tremulous parkinsonism. Mov Disord, 28(2), 145 - 152. 10.1002/mds.25220.
  27. Petrovic IN,Martin-Bastida A,Massey L,Ling H,O'Sullivan SS,Williams DR,Holton JL,Revesz T,Ironside JW,Lees AJ,Silveira-Moriyama L (2013) MM2 subtype of sporadic Creutzfeldt-Jakob disease may underlie the clinical presentation of progressive supranuclear palsy Journal of Neurology, 260(4), 1031 - 1036.
  28. Lees A,Costa R,Oliveira C,Lopes N,Nunes T,Soares-da-Silva P (2012) The design of a double-blind, placebo-controlled, multi-national phase-III trial in patients with Parkinson's disease and end-of-dose motor fluctuations: Opicapone superiority vs. placebo MOVEMENT DISORDERS, 27, S127 - S127.
  29. Glass P,Lees A,Bacellar A,Zijlmans J,Katzenschlager R,Silveira-Moriyama L (2012) Clinical Features of Vascular Parkinsonism in Pathologically Confirmed Cases NEUROLOGY, 78.
  30. Doherty KM,Noyce AJ,Silveira-Moriyama L,Nisbet A,Quinn N,Lees AJ (2012) Familial camptocormia: from dystonia to myopathy. J Neurol Neurosurg Psychiatry, 83(3), 350 - 351. 10.1136/jnnp.2011.246561.
  31. Stockner H,Schwingenschuh P,Djamshidian A,Silveira-Moriyama L,Katschnig P,Seppi K,Dickson J,Edwards MJ,Lees AJ,Poewe W,Bhatia KP (2012) Is transcranial sonography useful to distinguish scans without evidence of dopaminergic deficit patients from Parkinson's disease? Movement Disorders, 27(9), 1182 - 1185.
  32. Kruer MC,Paudel R,Wagoner W,Sanford L,Kara E,Gregory A,Foltynie T,Lees A,Bhatia K,Hardy J,Hayflick SJ,Houlden H (2012) Analysis of ATP13A2 in large neurodegeneration with brain iron accumulation (NBIA) and dystonia-parkinsonism cohorts Neuroscience Letters, 523(1), 35 - 38.
  33. Xiromerisiou G,Houlden H,Scarmeas N,Stamelou M,Kara E,Hardy J,Lees AJ,Korlipara P,Limousin P,Paudel R,Hadjigeorgiou GM,Bhatia KP (2012) THAP1 mutations and dystonia phenotypes: Genotype phenotype correlations Movement Disorders, 27(10), 1290 - 1294.
  34. Doherty KM,Silveira-Moriyama L,Giladi N,Bhatia KP,Parton M,Lees AJ (2012) Camptocormia: don't forget muscle disease in the movement disorder clinic. J Neurol, 259(8), 1752 - 1754. 10.1007/s00415-012-6448-z.
  35. Djamshidian A,O'Sullivan SS,Lees A,Averbeck BB (2012) Effects of dopamine on sensitivity to social bias in Parkinson's disease. PLoS One, 7(3), e32889. 10.1371/journal.pone.0032889.
  36. Silveira-Moriyama L,Lees AJ (2012) Tricks of the trade | Pulo do gato Arquivos de Neuro-Psiquiatria, 70(4), 245 - 245.
  37. Moscovich M,Munhoz RP,Teive H,Raskin S,Carvalho MDJ,Barbosa ER,Ranvaud R,Liu J,McFarland K,Ashizawa T,Lees AJ,Silveira-Moriyama L (2012) Olfactory impairment in familial ataxias Journal of Neurology, Neurosurgery and Psychiatry.
  38. Kruer MC,Paudel R,Wagoner W,Sanford L,Kara E,Gregory A,Foltynie T,Lees A,Bhatia K,Hardy J,Hayflick SJ,Houlden H (2012) Analysis of ATP13A2 in large neurodegeneration with brain iron accumulation (NBIA) and dystonia-parkinsonism cohorts. Neurosci Lett, 523(1), 35 - 38. 10.1016/j.neulet.2012.06.036.
  39. Camargos S,Lees AJ,Singleton A,Cardoso F (2012) DYT16: The original cases Journal of Neurology, Neurosurgery and Psychiatry.
  40. Massey LA,Miranda MA,Zrinzo L,Al-Helli O,Parkes HG,Thornton JS,So PW,White MJ,Mancini L,Strand C,Holton JL,Hariz MI,Lees AJ,Revesz T,Yousry TA (2012) High resolution MR anatomy of the subthalamic nucleus: imaging at 9.4 T with histological validation. Neuroimage, 59(3), 2035 - 2044. 10.1016/j.neuroimage.2011.10.016.
  41. Xiromerisiou G,Houlden H,Sailer A,Silveira-Moriyama L,Hardy J,Lees AJ (2012) Identical twins with Leucine rich repeat kinase type 2 mutations discordant for Parkinson's disease. Mov Disord, 27(10), 1323. 10.1002/mds.24924.
  42. Ozawa T,Revesz T,Paviour D,Lees AJ,Quinn N,Tada M,Kakita A,Onodera O,Wakabayashi K,Takahashi H,Nishizawa M,Holton JL (2012) Difference in MSA phenotype distribution between populations: Genetics or environment? Journal of Parkinson's Disease, 2(1), 7 - 18.
  43. Lin MT,Cantuti-Castelvetri I,Zheng K,Jackson KE,Tan YB,Arzberger T,Lees AJ,Betensky RA,Beal MF,Simon DK (2012) Somatic mitochondrial DNA mutations in early Parkinson and incidental lewy body disease Annals of Neurology, 71(6), 850 - 854.
  44. Djamshidian A,O'Sullivan SS,Sanotsky Y,Sharman S,Matviyenko Y,Foltynie T,Michalczuk R,Aviles-Olmos I,Fedoryshyn L,Doherty KM,Filts Y,Selikhova M,Bowden-Jones H,Joyce E,Lees AJ,Averbeck BB (2012) Decision making, impulsivity, and addictions: Do Parkinson's disease patients jump to conclusions? Movement Disorders.
  45. Kara E,Ling H,Pittman AM,Shaw K,de Silva R,Simone R,Holton JL,Warren JD,Rohrer JD,Xiromerisiou G,Lees A,Hardy J,Houlden H,Revesz T (2012) The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features Neurobiology of Aging, 33(9), 2231e7 - 2231e14.
  46. Ling H,Massey LA,Lees AJ,Brown P,Day BL (2012) Hypokinesia without decrement distinguishes progressive supranuclear palsy from Parkinson's disease. Brain, 135(Pt 4), 1141 - 1153. 10.1093/brain/aws038.
  47. Stockner H,Schwingenschuh P,Djamshidian A,Silveira-Moriyama L,Katschnig P,Seppi K,Dickson J,Edwards MJ,Lees AJ,Poewe W,Bhatia KP (2012) Is transcranial sonography useful to distinguish scans without evidence of dopaminergic deficit patients from Parkinson's disease? Mov Disord, 27(9), 1182 - 1185. 10.1002/mds.25102.
  48. Ling H,Massey LA,Lees AJ,Brown P,Day BL (2012) Hypokinesia without decrement distinguishes progressive supranuclear palsy from Parkinson's disease Brain, 135(4), 1141 - 1153.
  49. Kara E,Ling H,Pittman AM,Shaw K,de Silva R,Simone R,Holton JL,Warren JD,Rohrer JD,Xiromerisiou G,Lees A,Hardy J,Houlden H,Revesz T (2012) The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features Neurobiology of Aging.
  50. Ling H,Petrovic I,Day BL,Lees AJ (2012) Smoking-induced transient motor deterioration in a levodopa-treated patient with Parkinson's disease Journal of Neurology, 1 - 5.

Qualifications

  • 1987: Fellow of the Royal College of Physicians, Royal College of Physicians
  • 1978: Doctor of Medicine, University of London
  • 1974: Member of the Royal College of Physicians, Royal College of Physicians
  • 1970: Bachelor of Medicine/Bachelor of Surgery, University of London

Keywords

  • Alpha-synuclein
  • Basal ganglia
  • Brain
  • Brain imaging
  • Clinical trials
  • Clinical, Genetic and Pathological features of Parkinsons disease and PSP
  • Dementia - Lewy Body
  • Dopamine
  • Dystonia
  • Eye movement recording
  • Frontotemporal dementia
  • Functional MRI (fMRI)
  • Gene expression
  • Gene expression profiling - tissue level
  • Histology
  • Image analysis
  • Immunohistochemistry
  • Light microscopic techniques
  • MRI
  • MRNA
  • Magnetic resonance imaging (MRI)
  • Movement disorders
  • Multiple system atrophy
  • Neurodegeneration
  • Neuropathology
  • Obsessive-compulsive disorder
  • Olfaction
  • Olivopontocerebellar atrophy
  • Parkinson's disease
  • Progressive Supranuclear Palsy
  • Tourette syndrome
  • Tremor