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Prof Aroon Hingorani
Telephone:
020 3108 3080Extension:
53080Fax:
020 7813 0242Email:
a.hingorani@ucl.ac.ukAddress:
109 1-19 Torrington Place,
London,
WC1E 6BTAppointments:
Chair of Genetic Epidemiology (Honorary Consultant), Institute of Cardiovascular Science, Faculty of Population Health Sciences

Research Summary
The Genetic Epidemiology Group, led by Professor Aroon Hingorani (British Heart Foundation Senior Research Fellow), investigates the implications (and applications) of new genetic advances for personal and public health. The work is interdisciplinary, integrative and collaborative. The Institute of Epidemiology and Health Care hosts several large, highly phenotyped population-based cohort studies that provide an excellent resource for genetic epidemiology. The group plays a central role in large-scale collaborative studies both nationally and internationally. There are close collaborations with groups engaged in health outcomes research and research using national disease registries. The aims of the group are thus closely aligned to those of the Institute as a whole, which are to enhance the health of patients and populations by promoting public health and improving clinical care. The skills mix of epidemiological, clinical, statistical and behavioural science in the Institute provides the scientific basis to underpin our internationally competitive programme.
There have been a range of strategic developments at UCL that facilitate the work of the group. Support for genotyping and bioinformatics exists through UCL and Partners centralized platform technology service (http://www.ucl.ac.uk/researchdeanery/platform_technologies/) and UCL Genomics (http://www.genomics.ucl.ac.uk/). The Genetic Epidemiology Research Group is also affiliated to the newly created UCL Genetics Institute (http://www.ucl.ac.uk/ugi/), which offers centralized core support for bioinformatics, and statistical genetics as well as providing a framework for interfaculty research in human genetics across UCL. Members and affiliates of UGI include clinicians, geneticists, epidemiologists and statisticians. Much of the work of the Genetic Epidemiology Research group is in the field of cardiovascular disease and there are also established and expanding links with the basic sciences and clinical research in cardiovascular disease through the Division of Medicine and the UCL Institute of Cardiovascular Sciences (http://www.ucl.ac.uk/cardiovascular/). Finally, there are established and highly productive links with several groups in the Non-Communicable Disease Epidemiology Unit at London School of Hygiene and Tropical Medicine, including links with statistical genetics.
Current areas of activity include:
* Using genetic approaches to understand causal pathways in the onset and progression of common complex disease;
* Exploring the potential for large scale genetic studies in highly phenotyped populations to model the effects of new drug therapies;
* Co-ordination of collaborative genetic work involving the population studies hosted by the Division to exploit opportunities for pooled cross-cohort analyses for the understanding of the factors governing the development of chronic diseases;
* Contributing to the development and application of appropriate methods for the design, conduct and analysis of large scale population studies incorporating genomic information, and the implementation of the findings for risk prediction and causal inference.
Research Activities
- A life course approach to the study of adult physical capability
- A wide range of cardiovascular diseases
- Cardiovascular disease
- Critical Care Medicine
- Epidemiology and public health
- Genetic epidemiology of cardiovascular disease
- Interface between physical health and mental health
- Nuclear receptor post-translational modifications in cardiovascular disease and inflammation
Recent Publications
Displaying 50 most recent publications. For the full list please visit UCL Discovery
- Hu Y,Li L,Ehm MG,Bing N,Song K,Nelson MR,Talmud PJ,Hingorani AD,Kumari M,Kivimäki M,Xu CF,Waterworth DM,Whittaker JC,Abecasis GR,Spino C,Kang HM (2013) The benefits of using genetic information to design prevention trials. Am J Hum Genet, 92(4), 547 - 557. 10.1016/j.ajhg.2013.03.003.
- Shah T,Zabaneh D,Gaunt T,Swerdlow DI,Shah S,Talmud PJ,Day IN,Whittaker J,Holmes MV,Sofat R,Humphries SE,Kivimaki M,Kumari M,Hingorani AD,Casas JP (2013) Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. Circ Cardiovasc Genet, 6(2), 163 - 170. 10.1161/CIRCGENETICS.112.964254.
- Talmud PJ,Shah S,Whittall R,Futema M,Howard P,Cooper JA,Harrison SC,Li K,Drenos F,Karpe F,Neil HA,Descamps OS,Langenberg C,Lench N,Kivimaki M,Whittaker J,Hingorani AD,Kumari M,Humphries SE (2013) Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study. Lancet, 381(9874), 1293 - 1301. 10.1016/S0140-6736(12)62127-8.
- den Hoed M,Luan J,Langenberg C,Cooper C,Sayer AA,Jameson K,Kumari M,Kivimaki M,Hingorani AD,Grøntved A,Khaw KT,Ekelund U,Wareham NJ,Loos RJ (2013) Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples. Int J Obes (Lond), 37(2), 191 - 196. 10.1038/ijo.2012.34.
- Chakravarthy U,McKay GJ,de Jong PT,Rahu M,Seland J,Soubrane G,Tomazzoli L,Topouzis F,Vingerling JR,Vioque J,Young IS,Sofat R,Hingorani AD,Fletcher AE (2013) ARMS2 increases the risk of early and late age-related macular degeneration in the European Eye Study. Ophthalmology, 120(2), 342 - 348. 10.1016/j.ophtha.2012.08.004.
- Shah S,Casas JP,Gaunt TR,Cooper J,Drenos F,Zabaneh D,Swerdlow DI,Shah T,Sofat R,Palmen J,Kumari M,Kivimaki M,Ebrahim S,Smith GD,Lawlor DA,Talmud PJ,Whittaker J,Day IN,Hingorani AD,Humphries SE (2013) Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies. Eur Heart J, 34(13), 972 - 981. 10.1093/eurheartj/ehs243.
- Shah S,Casas JP,Drenos F,Whittaker J,Deanfield J,Swerdlow DI,Holmes MV,Kivimaki M,Langenberg C,Wareham N,Gertow K,Sennblad B,Strawbridge RJ,Baldassarre D,Veglia F,Tremoli E,Gigante B,de Faire U,Kumari M,Talmud PJ,Hamsten A,Humphries SE,Hingorani AD (2013) Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis. Circ Cardiovasc Genet, 6(1), 63 - 72. 10.1161/CIRCGENETICS.112.963140.
- Harrison SC,Zabaneh D,Asselbergs FW,Drenos F,Jones GT,Shah S,Gertow K,Sennblad B,Strawbridge RJ,Gigante B,Holewijn S,De Graaf J,Vermeulen S,Folkersen L,van Rij AM,Baldassarre D,Veglia F,Talmud PJ,Deanfield JE,Agu O,Kivimaki M,Kumari M,Bown MJ,Nyyssönen K,Rauramaa R,Smit AJ,Franco-Cereceda A,Giral P,Mannarino E,Silveira A,Syvänen A-C,de Borst GJ,van der Graaf Y,de Faire U,Baas AF,Blankensteijn JD,Wareham NJ,Fowkes G,Tzoulaki I,Price JF,Tremoli E,Hingorani AD,Eriksson P,Hamsten A,Humphries SE (2012) A gene-centric study of common carotid artery remodelling Atherosclerosis.
- Jones A,Charakida M,Falaschetti E,Hingorani AD,Finer N,Masi S,Donald AE,Lawlor DA,Smith GD,Deanfield JE (2012) Adipose and height growth through childhood and blood pressure status in a large prospective cohort study. Hypertension, 59(5), 919 - 925. 10.1161/HYPERTENSIONAHA.111.187716.
- Staines-Urias E,Paez MC,Doyle P,Dudbridge F,Serrano NC,Ioannidis JP,Keating BJ,Hingorani AD,Casas JP (2012) Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis. Int J Epidemiol, 41(6), 1764 - 1775. 10.1093/ije/dys162.
- Gaunt TR,Shah S,Nelson CP,Drenos F,Braund PS,Adeniran I,Folkersen L,Lawlor DA,Casas JP,Amuzu A,Kivimaki M,Whittaker J,Eriksson P,Zhang H,Hancox JC,Tomaszewski M,Burton PR,Tobin MD,Humphries SE,Talmud PJ,Macfarlane PW,Hingorani AD,Samani NJ,Kumari M,Day IN (2012) Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip. Circ Cardiovasc Genet, 5(6), 630 - 638. 10.1161/CIRCGENETICS.112.962852.
- Douglas IJ,Evans SJ,Hingorani AD,Grosso AM,Timmis A,Hemingway H,Smeeth L (2012) Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs. BMJ, 345, e4388.
- Costelloe SJ,El-Sayed Moustafa JS,Drenos F,Palmen J,Li Q,Whiting S,Thomas M,Kivimaki M,Kumari M,Hingorani AD,Tzoulaki I,Järvelin MR,Ruokonen A,Hartikainen AL,Pouta A,Walters RG,Blakemore AI,Humphries SE,Coin LJ,Talmud PJ (2012) Gene-targeted analysis of copy number variants identifies 3 novel associations with coronary heart disease traits. Circ Cardiovasc Genet, 5(5), 555 - 560. 10.1161/CIRCGENETICS.111.961037.
- Hingorani AD,Sofat R,Morris RW,Whincup P,Lowe GD,Mindell J,Sattar N,Casas JP,Shah T (2012) Is it important to measure or reduce C-reactive protein in people at risk of cardiovascular disease? Eur Heart J, 33(18), 2258 - 2264. 10.1093/eurheartj/ehs168.
- Harrison SC,Smith AJ,Jones GT,Swerdlow DI,Rampuri R,Bown MJ,on behalf of the Aneurysm Consortium ,Folkersen L,Baas AF,de Borst GJ,Blankensteijn JD,Price JF,van der Graaf Y,McLachlan S,Agu O,Hofman A,Uitterlinden AG,Franco-Cereceda A,Ruigrok YM,Van't Hof FN,Powell JT,van Rij AM,Casas JP,Eriksson P,Holmes MV,Asselbergs FW,Hingorani AD,Humphries SE (2012) Interleukin-6 receptor pathways in abdominal aortic aneurysm. Eur Heart J. 10.1093/eurheartj/ehs354.
- Asselbergs F,Guo Y,van Iperen EA,Sivapalaratnam S,Tragante V,Lanktree M,Lange L,Almoguera B,Appelman Y,Barnard J,Baumert J,Beitelshees A,Bhangale T,Chen Y-D,Gaunt T,Gong Y,Hopewell J,Johnson T,Kleber M,Langaee T,Li M,Li Y,Liu K,McDonough C,Meijs ML,Middelberg RS,Musunuru K,Nelson C,O'Connell J,Padmanabhan S,Pankow J,Pankratz N,Rafelt S,Rajagopalan R,Romaine SR,Schork N,Shaffer J,Shen H,Smith E,Tischfield S,van der Most P,van Vliet-Ostaptchouk J,Verweij N,Volcik K,Zhang L,Bailey K,Bailey K,Bauer F,Boer JA,Braund P,Burt A,Burton P,Buxbaum S,Chen W,Cooper-DeHoff R,Cupples L,deJong J,Delles C,Duggan D,Fornage M,Furlong C,Glazer N,Gums J,Hastie C,Holmes M,Illig T,Kirkland S,Kivimaki M,Klein R,Klein B,Kooperberg C,Kottke-Marchant K,Kumari M,LaCroix A,Mallela L,Murugesan G,Ordovas J,Ouwehand W,Post W,Saxena R,Scharnagl H,Schreiner P,Shah T,Shields D,Shimbo D,Srinivasan S,Stolk R,Swerdlow D,Taylor Jr H,Topol E,Toskala E,van Pelt J,van Setten J,Yusuf S,Whittaker J,Zwinderman AH,Anand S,Balmforth A,Berenson G,Bezzina C,Boehm B,Boerwinkle E,Casas J,Caulfield M,Clarke R,Connell J,Cruickshanks K,Davidson K,Day IM,de Bakker PW,Doevendans P,Dominiczak A,Hall A,Hartman C,Hengstenberg C,Hillege H,Hofker M,Humphries S,Jarvik G,Johnson J,Kaess B,Kathiresan S,Koenig W,Lawlor D,März W,Melander O,Mitchell B,Montgomery G,Munroe P,Murray S,Newhouse S,Onland-Moret N,Poulter N,Psaty B,Redline S,Rich S,Rotter J,Schunkert H,Sever P,Shuldiner A,Silverstein R,Stanton A,Thorand B,Trip M,Tsai M,van der Harst P,van der Schoot E,van der Schouw Y,Verschuren WM,Watkins H,Wilde AM,Wolffenbuttel BR,Whitfield J,Hovingh G,Ballantyne C,Wijmenga C,Reilly M,Martin N,Wilson J,Rader D,Samani N,Reiner A,Hegele R,Kastelein JP,Hingorani A,Talmud P,Hakonarson H,Elbers C,Keating B,Drenos F (2012) Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci American Journal of Human Genetics.
- Smith AJP,Howard P,Shah S,Eriksson P,Stender S,Giambartolomei C,Folkersen L,Tybjærg-Hansen A,Kumari M,Palmen J,Hingorani AD,Talmud PJ,Humphries SE (2012) Use of Allele-Specific FAIRE to Determine Functional Regulatory Polymorphism Using Large-Scale Genotyping Arrays PLoS Genetics, 8(8).
- Berry DJ,Vimaleswaran KS,Whittaker JC,Hingorani AD,Hyppönen E (2012) Evaluation of genetic markers as instruments for Mendelian randomization studies on vitamin D. PLoS One, 7(5), e37465. 10.1371/journal.pone.0037465.
- Holmes MV,Hingorani AD,Casas JP (2012) CYP2C19 Genotype and Cardiovascular Events Reply JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 307(14), 1484 - 1485.
- Munafò MR,Timofeeva MN,Morris RW,Prieto-Merino D,Sattar N,Brennan P,Johnstone EC,Relton C,Johnson PC,Walther D,Whincup PH,Casas JP,Uhl GR,Vineis P,Padmanabhan S,Jefferis BJ,Amuzu A,Riboli E,Upton MN,Aveyard P,Ebrahim S,Hingorani AD,Watt G,Palmer TM,Timpson NJ,EPIC Study Group ,Davey Smith G (2012) Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure. J Natl Cancer Inst, 104(10), 740 - 748. 10.1093/jnci/djs191.
- Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium ,Hingorani AD,Casas JP (2012) The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet, 379(9822), 1214 - 1224. 10.1016/S0140-6736(12)60110-X.
- Papp AC,Pinsonneault JK,Wang D,Newman LC,Gong Y,Johnson JA,Pepine CJ,Kumari M,Hingorani AD,Talmud PJ,Shah S,Humphries SE,Sadee W (2012) Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk. PLoS One, 7(3), e31930. 10.1371/journal.pone.0031930.
- Sutaria S,Philipson P,Fitzpatrick NK,Abrams K,Moreno SG,Timmis A,Hingorani AD,Hemingway H (2012) Translational phases of evidence in a prognostic biomarker: a systematic review and meta-analysis of natriuretic peptides and the prognosis of stable coronary disease. Heart, 98(8), 615 - 622. 10.1136/heartjnl-2011-300862.
- Saxena R,Elbers CC,Guo Y,Peter I,Gaunt TR,Mega JL,Lanktree MB,Tare A,Castillo BA,Li YR,Johnson T,Bruinenberg M,Gilbert-Diamond D,Rajagopalan R,Voight BF,Balasubramanyam A,Barnard J,Bauer F,Baumert J,Bhangale T,Böhm BO,Braund PS,Burton PR,Chandrupatla HR,Clarke R,Cooper-DeHoff RM,Crook ED,Davey-Smith G,Day IN,de Boer A,de Groot MC,Drenos F,Ferguson J,Fox CS,Furlong CE,Gibson Q,Gieger C,Gilhuijs-Pederson LA,Glessner JT,Goel A,Gong Y,Grant SF,Grobbee DE,Hastie C,Humphries SE,Kim CE,Kivimaki M,Kleber M,Meisinger C,Kumari M,Langaee TY,Lawlor DA,Li M,Lobmeyer MT,Maitland-van der Zee AH,Meijs MF,Molony CM,Morrow DA,Murugesan G,Musani SK,Nelson CP,Newhouse SJ,O'Connell JR,Padmanabhan S,Palmen J,Patel SR,Pepine CJ,Pettinger M,Price TS,Rafelt S,Ranchalis J,Rasheed A,Rosenthal E,Ruczinski I,Shah S,Shen H,Silbernagel G,Smith EN,Spijkerman AW,Stanton A,Steffes MW,Thorand B,Trip M,van der Harst P,van der A DL,van Iperen EP,van Setten J,van Vliet-Ostaptchouk JV,Verweij N,Wolffenbuttel BH,Young T,Zafarmand MH,Zmuda JM,Look AHEAD Research Group ,DIAGRAM consortium ,Boehnke M,Altshuler D,McCarthy M,Kao WH,Pankow JS,Cappola TP,Sever P,Poulter N,Caulfield M,Dominiczak A,Shields DC,Bhatt DL,Zhang L,Curtis SP,Danesh J,Casas JP,van der Schouw YT,Onland-Moret NC,Doevendans PA,Dorn GW,Farrall M,FitzGerald GA,Hamsten A,Hegele R,Hingorani AD,Hofker MH,Huggins GS,Illig T,Jarvik GP,Johnson JA,Klungel OH,Knowler WC,Koenig W,März W,Meigs JB,Melander O,Munroe PB,Mitchell BD,Bielinski SJ,Rader DJ,Reilly MP,Rich SS,Rotter JI,Saleheen D,Samani NJ,Schadt EE,Shuldiner AR,Silverstein R,Kottke-Marchant K,Talmud PJ,Watkins H,Asselbergs FW,de Bakker PI,McCaffery J,Wijmenga C,Sabatine MS,Wilson JG,Reiner A,Bowden DW,Hakonarson H,Siscovick DS,Keating BJ (2012) Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet, 90(3), 410 - 425. 10.1016/j.ajhg.2011.12.022.
- Palmer ND,McDonough CW,Hicks PJ,Roh BH,Wing MR,An SS,Hester JM,Cooke JN,Bostrom MA,Rudock ME,Talbert ME,Lewis JP,DIAGRAM Consortium ,MAGIC Investigators ,Ferrara A,Lu L,Ziegler JT,Sale MM,Divers J,Shriner D,Adeyemo A,Rotimi CN,Ng MC,Langefeld CD,Freedman BI,Bowden DW,Voight BF,Scott LJ,Steinthorsdottir V,Morris AP,Dina C,Welch RP,Zeggini E,Huth C,Aulchenko YS,Thorleifsson G,McCulloch LJ,Ferreira T,Grallert H,Amin N,Wu G,Willer CJ,Raychaudhuri S,McCarroll SA,Langenberg C,Hofmann OM,Dupuis J,Qi L,Segrè AV,van Hoek M,Navarro P,Ardlie K,Balkau B,Benediktsson R,Bennett AJ,Blagieva R,Boerwinkle E,Bonnycastle LL,Boström KB,Bravenboer B,Bumpstead S,Burtt NP,Charpentier G,Chines PS,Cornelis M,Couper DJ,Crawford G,Doney AS,Elliott KS,Elliott AL,Erdos MR,Fox CS,Franklin CS,Ganser M,Gieger C,Grarup N,Green T,Griffin S,Groves CJ,Guiducci C,Hadjadj S,Hassanali N,Herder C,Isomaa B,Jackson AU,Johnson PR,Jørgensen T,Kao WH,Klopp N,Kong A,Kraft P,Kuusisto J,Lauritzen T,Li M,Lieverse A,Lindgren CM,Lyssenko V,Marre M,Meitinger T,Midthjell K,Morken MA,Narisu N,Nilsson P,Owen KR,Payne F,Perry JR,Petersen AK,Platou C,Proença C,Prokopenko I,Rathmann W,Rayner NW,Robertson NR,Rocheleau G,Roden M,Sampson MJ,Saxena R,Shields BM,Shrader P,Sigurdsson G,Sparsø T,Strassburger K,Stringham HM,Sun Q,Swift AJ,Thorand B,Tichet J,Tuomi T,van Dam RM,van Haeften TW,van Herpt T,van Vliet-Ostaptchouk JV,Walters GB,Weedon MN,Wijmenga C,Witteman J,Bergman RN,Cauchi S,Collins FS,Gloyn AL,Gyllensten U,Hansen T,Hide WA,Hitman GA,Hofman A,Hunter DJ,Hveem K,Laakso M,Mohlke KL,Morris AD,Palmer CN,Pramstaller PP,Rudan I,Sijbrands E,Stein LD,Tuomilehto J,Uitterlinden A,Walker M,Wareham NJ,Watanabe RM,Abecasis GR,Boehm BO,Campbell H,Daly MJ,Hattersley AT,Hu FB,Meigs JB,Pankow JS,Pedersen O,Wichmann HE,Barroso I,Florez JC,Frayling TM,Groop L,Sladek R,Thorsteinsdottir U,Wilson JF,Illig T,Froguel P,van Duijn CM,Stefansson K,Altshuler D,Boehnke M,McCarthy MI,Soranzo N,Wheeler E,Glazer NL,Bouatia-Naji N,Mägi R,Randall J,Johnson T,Elliott P,Rybin D,Henneman P,Dehghan A,Hottenga JJ,Song K,Goel A,Egan JM,Lajunen T,Doney A,Kanoni S,Cavalcanti-Proença C,Kumari M,Timpson NJ,Zabena C,Ingelsson E,An P,O'Connell J,Luan J,Elliott A,McCarroll SA,Roccasecca RM,Pattou F,Sethupathy P,Ariyurek Y,Barter P,Beilby JP,Ben-Shlomo Y,Bergmann S,Bochud M,Bonnefond A,Borch-Johnsen K,Böttcher Y,Brunner E,Bumpstead SJ,Chen YD,Chines P,Clarke R,Coin LJ,Cooper MN,Crisponi L,Day IN,de Geus EJ,Delplanque J,Fedson AC,Fischer-Rosinsky A,Forouhi NG,Frants R,Franzosi MG,Galan P,Goodarzi MO,Graessler J,Grundy S,Gwilliam R,Hallmans G,Hammond N,Han X,Hartikainen AL,Hayward C,Heath SC,Hercberg S,Hicks AA,Hillman DR,Hingorani AD,Hui J,Hung J,Jula A,Kaakinen M,Kaprio J,Kesaniemi YA,Kivimaki M,Knight B,Koskinen S,Kovacs P,Kyvik KO,Lathrop GM,Lawlor DA,Le Bacquer O,Lecoeur C,Li Y,Mahley R,Mangino M,Manning AK,Martínez-Larrad MT,McAteer JB,McPherson R,Meisinger C,Melzer D,Meyre D,Mitchell BD,Mukherjee S,Naitza S,Neville MJ,Oostra BA,Orrù M,Pakyz R,Paolisso G,Pattaro C,Pearson D,Peden JF,Pedersen NL,Perola M,Pfeiffer AF,Pichler I,Polasek O,Posthuma D,Potter SC,Pouta A,Province MA,Psaty BM,Rayner NW,Rice K,Ripatti S,Rivadeneira F,Rolandsson O,Sandbaek A,Sandhu M,Sanna S,Sayer AA,Scheet P,Seedorf U,Sharp SJ,Shields B,Sijbrands EJ,Silveira A,Simpson L,Singleton A,Smith NL,Sovio U,Swift A,Syddall H,Syvänen AC,Tanaka T,Tönjes A,Uitterlinden AG,van Dijk KW,Varma D,Visvikis-Siest S,Vitart V,Vogelzangs N,Waeber G,Wagner PJ,Walley A,Ward KL,Watk (2012) A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One, 7(1), e29202. 10.1371/journal.pone.0029202.
- Sofat R,Casas JP,Grosso AM,Prichard BNC,Smeeth L,MacAllister R,Hingorani AD (2012) Could NICE guidance on the choice of blood pressure lowering drugs be simplified? BRITISH MEDICAL JOURNAL, 344. 10.1136/bmj.d8078.
- Sofat R,Casas JP,Grosso AM,Prichard BN,Smeeth L,MacAllister R,Hingorani AD (2012) Could NICE guidance on the choice of blood pressure lowering drugs be simplified? BMJ, 344, d8078.
- Sofat R,Casas JP,Webster AR,Bird AC,Mann SS,Yates JR,Moore AT,Sepp T,Cipriani V,Bunce C,Khan JC,Shahid H,Swaroop A,Abecasis G,Branham KE,Zareparsi S,Bergen AA,Klaver CC,Baas DC,Zhang K,Chen Y,Gibbs D,Weber BH,Keilhauer CN,Fritsche LG,Lotery A,Cree AJ,Griffiths HL,Bhattacharya SS,Chen LL,Jenkins SA,Peto T,Lathrop M,Leveillard T,Gorin MB,Weeks DE,Ortube MC,Ferrell RE,Jakobsdottir J,Conley YP,Rahu M,Seland JH,Soubrane G,Topouzis F,Vioque J,Tomazzoli L,Young I,Whittaker J,Chakravarthy U,de Jong PT,Smeeth L,Fletcher A,Hingorani AD (2012) Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype. Int J Epidemiol, 41(1), 250 - 262. 10.1093/ije/dyr204.
- Yiannakouris N,Cooper JA,Shah S,Drenos F,Ireland HA,Stephens JW,Li KW,Elkeles R,Godsland IF,Kivimaki M,Hingorani AD,Kumari M,Talmud PJ,Humphries SE (2012) IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk. Nutr Metab Cardiovasc Dis, 22(12), 1024 - 1030. 10.1016/j.numecd.2011.05.009.
- Angelakopoulou A,Shah T,Sofat R,Shah S,Berry DJ,Cooper J,Palmen J,Tzoulaki I,Wong A,Jefferis BJ,Maniatis N,Drenos F,Gigante B,Hardy R,Laxton RC,Leander K,Motterle A,Simpson IA,Smeeth L,Thomson A,Verzilli C,Kuh D,Ireland H,Deanfield J,Caulfield M,Wallace C,Samani N,Munroe PB,Lathrop M,Fowkes FG,Marmot M,Whincup PH,Whittaker JC,de Faire U,Kivimaki M,Kumari M,Hypponen E,Power C,Humphries SE,Talmud PJ,Price J,Morris RW,Ye S,Casas JP,Hingorani AD (2012) Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Eur Heart J, 33(3), 393 - 407. 10.1093/eurheartj/ehr225.
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- International Consortium for Blood Pressure Genome-Wide Association Studies ,Ehret GB,Munroe PB,Rice KM,Bochud M,Johnson AD,Chasman DI,Smith AV,Tobin MD,Verwoert GC,Hwang SJ,Pihur V,Vollenweider P,O'Reilly PF,Amin N,Bragg-Gresham JL,Teumer A,Glazer NL,Launer L,Zhao JH,Aulchenko Y,Heath S,Sõber S,Parsa A,Luan J,Arora P,Dehghan A,Zhang F,Lucas G,Hicks AA,Jackson AU,Peden JF,Tanaka T,Wild SH,Rudan I,Igl W,Milaneschi Y,Parker AN,Fava C,Chambers JC,Fox ER,Kumari M,Go MJ,van der Harst P,Kao WH,Sjögren M,Vinay DG,Alexander M,Tabara Y,Shaw-Hawkins S,Whincup PH,Liu Y,Shi G,Kuusisto J,Tayo B,Seielstad M,Sim X,Nguyen KD,Lehtimäki T,Matullo G,Wu Y,Gaunt TR,Onland-Moret NC,Cooper MN,Platou CG,Org E,Hardy R,Dahgam S,Palmen J,Vitart V,Braund PS,Kuznetsova T,Uiterwaal CS,Adeyemo A,Palmas W,Campbell H,Ludwig B,Tomaszewski M,Tzoulaki I,Palmer ND,CARDIoGRAM consortium ,CKDGen Consortium ,KidneyGen Consortium ,EchoGen consortium ,CHARGE-HF consortium ,Aspelund T,Garcia M,Chang YP,O'Connell JR,Steinle NI,Grobbee DE,Arking DE,Kardia SL,Morrison AC,Hernandez D,Najjar S,McArdle WL,Hadley D,Brown MJ,Connell JM,Hingorani AD,Day IN,Lawlor DA,Beilby JP,Lawrence RW,Clarke R,Hopewell JC,Ongen H,Dreisbach AW,Li Y,Young JH,Bis JC,Kähönen M,Viikari J,Adair LS,Lee NR,Chen MH,Olden M,Pattaro C,Bolton JA,Köttgen A,Bergmann S,Mooser V,Chaturvedi N,Frayling TM,Islam M,Jafar TH,Erdmann J,Kulkarni SR,Bornstein SR,Grässler J,Groop L,Voight BF,Kettunen J,Howard P,Taylor A,Guarrera S,Ricceri F,Emilsson V,Plump A,Barroso I,Khaw KT,Weder AB,Hunt SC,Sun YV,Bergman RN,Collins FS,Bonnycastle LL,Scott LJ,Stringham HM,Peltonen L,Perola M,Vartiainen E,Brand SM,Staessen JA,Wang TJ,Burton PR,Soler Artigas M,Dong Y,Snieder H,Wang X,Zhu H,Lohman KK,Rudock ME,Heckbert SR,Smith NL,Wiggins KL,Doumatey A,Shriner D,Veldre G,Viigimaa M,Kinra S,Prabhakaran D,Tripathy V,Langefeld CD,Rosengren A,Thelle DS,Corsi AM,Singleton A,Forrester T,Hilton G,McKenzie CA,Salako T,Iwai N,Kita Y,Ogihara T,Ohkubo T,Okamura T,Ueshima H,Umemura S,Eyheramendy S,Meitinger T,Wichmann HE,Cho YS,Kim HL,Lee JY,Scott J,Sehmi JS,Zhang W,Hedblad B,Nilsson P,Smith GD,Wong A,Narisu N,Stančáková A,Raffel LJ,Yao J,Kathiresan S,O'Donnell CJ,Schwartz SM,Ikram MA,Longstreth WT,Mosley TH,Seshadri S,Shrine NR,Wain LV,Morken MA,Swift AJ,Laitinen J,Prokopenko I,Zitting P,Cooper JA,Humphries SE,Danesh J,Rasheed A,Goel A,Hamsten A,Watkins H,Bakker SJ,van Gilst WH,Janipalli CS,Mani KR,Yajnik CS,Hofman A,Mattace-Raso FU,Oostra BA,Demirkan A,Isaacs A,Rivadeneira F,Lakatta EG,Orru M,Scuteri A,Ala-Korpela M,Kangas AJ,Lyytikäinen LP,Soininen P,Tukiainen T,Würtz P,Ong RT,Dörr M,Kroemer HK,Völker U,Völzke H,Galan P,Hercberg S,Lathrop M,Zelenika D,Deloukas P,Mangino M,Spector TD,Zhai G,Meschia JF,Nalls MA,Sharma P,Terzic J,Kumar MV,Denniff M,Zukowska-Szczechowska E,Wagenknecht LE,Fowkes FG,Charchar FJ,Schwarz PE,Hayward C,Guo X,Rotimi C,Bots ML,Brand E,Samani NJ,Polasek O,Talmud PJ,Nyberg F,Kuh D,Laan M,Hveem K,Palmer LJ,van der Schouw YT,Casas JP,Mohlke KL,Vineis P,Raitakari O,Ganesh SK,Wong TY,Tai ES,Cooper RS,Laakso M,Rao DC,Harris TB,Morris RW,Dominiczak AF,Kivimaki M,Marmot MG,Miki T,Saleheen D,Chandak GR,Coresh J,Navis G,Salomaa V,Han BG,Zhu X,Kooner JS,Melander O,Ridker PM,Bandinelli S,Gyllensten UB,Wright AF,Wilson JF,Ferrucci L,Farrall M,Tuomilehto J,Pramstaller PP,Elosua R,Soranzo N,Sijbrands EJ,Altshuler D,Loos RJ,Shuldiner AR,Gieger C,Meneton P,Uitterlinden AG,Wareham NJ,Gudnason V,Rotter JI,Rettig R,Uda M,Strachan DP,Witteman JC,Harti (2011) Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478(7367), 103 - 109. 10.1038/nature10405.
- McKay GJ,Patterson CC,Chakravarthy U,Dasari S,Klaver CC,Vingerling JR,Ho L,de Jong PT,Fletcher AE,Young IS,Seland JH,Rahu M,Soubrane G,Tomazzoli L,Topouzis F,Vioque J,Hingorani AD,Sofat R,Dean M,Sawitzke J,Seddon JM,Peter I,Webster AR,Moore AT,Yates JR,Cipriani V,Fritsche LG,Weber BH,Keilhauer CN,Lotery AJ,Ennis S,Klein ML,Francis PJ,Stambolian D,Orlin A,Gorin MB,Weeks DE,Kuo CL,Swaroop A,Othman M,Kanda A,Chen W,Abecasis GR,Wright AF,Hayward C,Baird PN,Guymer RH,Attia J,Thakkinstian A,Silvestri G (2011) Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies. Hum Mutat, 32(12), 1407 - 1416. 10.1002/humu.21577.
- Holmes MV,Casas JP,Hingorani AD (2011) Putting genomics into practice. BMJ, 343, d4953.
- Holmes MV,Newcombe P,Hubacek JA,Sofat R,Ricketts SL,Cooper J,Breteler MM,Bautista LE,Sharma P,Whittaker JC,Smeeth L,Fowkes FG,Algra A,Shmeleva V,Szolnoki Z,Roest M,Linnebank M,Zacho J,Nalls MA,Singleton AB,Ferrucci L,Hardy J,Worrall BB,Rich SS,Matarin M,Norman PE,Flicker L,Almeida OP,van Bockxmeer FM,Shimokata H,Khaw KT,Wareham NJ,Bobak M,Sterne JA,Smith GD,Talmud PJ,van Duijn C,Humphries SE,Price JF,Ebrahim S,Lawlor DA,Hankey GJ,Meschia JF,Sandhu MS,Hingorani AD,Casas JP (2011) Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. Lancet, 378(9791), 584 - 594. 10.1016/S0140-6736(11)60872-6.
- Grosso AM,Bodalia PN,Macallister RJ,Hingorani AD,Moon JC,Scott MA (2011) Cost-saving opportunities and angiotensin-II receptor blocker prescribing. Int J Clin Pract, 65(8), 912. 10.1111/j.1742-1241.2011.02730.x.
- Fox ER,Young JH,Li Y,Dreisbach AW,Keating BJ,Musani SK,Liu K,Morrison AC,Ganesh S,Kutlar A,Ramachandran VS,Polak JF,Fabsitz RR,Dries DL,Farlow DN,Redline S,Adeyemo A,Hirschorn JN,Sun YV,Wyatt SB,Penman AD,Palmas W,Rotter JI,Townsend RR,Doumatey AP,Tayo BO,Mosley TH,Lyon HN,Kang SJ,Rotimi CN,Cooper RS,Franceschini N,Curb JD,Martin LW,Eaton CB,Kardia SL,Taylor HA,Caulfield MJ,Ehret GB,Johnson T,International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS) ,Chakravarti A,Zhu X,Levy D (2011) Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet, 20(11), 2273 - 2284. 10.1093/hmg/ddr092.
- Shah AD,Nicholas O,Timmis AD,Feder G,Abrams KR,Chen R,Hingorani AD,Hemingway H (2011) Threshold haemoglobin levels and the prognosis of stable coronary disease: two new cohorts and a systematic review and meta-analysis. PLoS Med, 8(5), e1000439. 10.1371/journal.pmed.1000439.
- Zabaneh D,Kumari M,Sandhu M,Wareham N,Wainwright N,Papamarkou T,Hopewell J,Clarke R,Li K,Palmen J,Talmud PJ,Kronenberg F,Lamina C,Summerer M,Paulweber B,Price J,Fowkes G,Stewart M,Drenos F,Shah S,Shah T,Casas JP,Kivimaki M,Whittaker J,Hingorani AD,Humphries SE (2011) Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts. Atherosclerosis, 217(2), 447 - 451. 10.1016/j.atherosclerosis.2011.04.015.
- Freathy RM,Kazeem GR,Morris RW,Johnson PC,Paternoster L,Ebrahim S,Hattersley AT,Hill A,Hingorani AD,Holst C,Jefferis BJ,Kring SI,Mooser V,Padmanabhan S,Preisig M,Ring SM,Sattar N,Upton MN,Vollenweider P,Waeber G,Sørensen TI,Frayling TM,Watt G,Lawlor DA,Whincup PH,Tozzi F,Davey Smith G,Munafò M (2011) Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. Int J Epidemiol, 40(6), 1617 - 1628. 10.1093/ije/dyr077.
There are no biographical details to display
Keywords
- Genetic epidemiology
- clinical trials
- screening and prevention
Collaborators
- Dr Leah Li
- Dr Mike Grocott
- Dr Gareth Ackland
- Dr Geoffrey Bellingan
- Prof Peter Scambler
- Dr Anne Peasey
- Dr Mark Peters
- Dr Irene Petersen
- Prof Christine Power
- Dr Ines Pineda Torra
- Prof Mika Kivimaki
- Prof Michael Marmot
- Dr Rumana Omar
- Prof Marcus Richards
- Prof Hugh Montgomery
- Prof John Martin
- Prof Mervyn Singer
- Prof Diana Kuh
- Prof Monty Mythen
- Dr Kate Walters
- Prof Irwin Nazareth
- Dr Greta Rait
- Dr Neil Bradman
- Prof Harry Hemingway
- Dr David Osborn
- Prof Steve Humphries
- Dr Ben Hanson
- Dr Olga Vikhireva
- Dr Ann Walker
