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Prof Anthony Dickenson
Telephone:020 7679 3742
Fax:020 7679 7298
Address:Pharmacology, Medical Sciences Building,
UCL South Cloisters, Gower St,
Appointments:Professor of Neuropharmacology, Neuroscience, Physiology & Pharmacology, Div of Biosciences
Building a team of motivated, communicative, proactive and skilled pain researchers has lead to almost 275 publications and an h index of 61. Informing and educating on pain mechanisms and analgesic targets, translation from preclinical to patients and public engagement. Involved in many advisory boards and spoken around the world (what a privilege) at Pain Congresses. Many collaborative projects and aiming to be approachable and affable to all.
Our research has been based on understanding the transmission and control of pain related to improving its treatment, either through better knowledge of mechanisms or characterization of novel targets. The approach has been to understand how pain changes the nervous system.The groupI have studied how neuronal systems alter in patho-physiological states and how novel and licensed drugs produce their effects on pain processes. We have made many major advances in this area and the aim has been to translate the basic research into clinical applications.
Early on we described Diffuse Noxious Inhibitory controls (DNIC) and subsequently provided a detailed description of their neural basis. DNIC are used as a possible diagnostic in chronic pain patients. At UCL, our original pioneering work on the neuronal actions of opioid receptors lead to major advances in opioid function, the idea of pre-emptive analgesia and other important clinical translations. We were the first group to show the NMDA receptor mediation of wind-up, then its role in persistent pain. This and our continuing work on central hyperexcitability has been seminal in understanding of pain in animals and humans.
We further initiated some of the very first studies on the pharmacology of the developing spinal cord related to paediatric pain control. We have studied a number of novel mediators ranging from nitric oxide, adenosine, nicotinic ligands and newer opioids. Assessment of drug combinations has also guided clinical practice.
More recently, we have taken our work on the plasticity of spinal signalling after inflammation to other pain states to examine changes after nerve injury and adapted and further developed a rodent model of bone cancer, all of which have informed clinical practice. At the same time we have some very fruitful collaborations with molecular groups. We have provided evidence for roles of targets that include sodium channels found in peripheral neurons and central G-protein linked receptors within integrated systems using levels and ranges of stimuli that cannot be assessed by behavioural approaches. Further advances using pharmacological tools are exemplified by functional identification of roles for Kv7/M and other potassium channels that could be novel pain targets. Ongoing active studies include assessing tissue specific knock-outs with Prof J Wood, and our original extensive work on calcium channel function in pain has lead to international collaborations on the roles of splice variants and over-expressing of calcium channel subunits. Finally, in the last 2 years, our original studies with novel techniques on spinal neurones that project to the brain and engage descending brainstem serotonergic influences to the cord to enhance spinal excitability have had major implications for the understanding how pain shapes emotional changes. We have shown the integrity of this pathway is a crucial determinant of both the abnormal neuronal and behavioural manifestation of nerve injury. This pathway also has a major bearing on efficacy of drugs used in neuropathic pain and has been verified in humans through imaging and clinical trials of novel analgesics.
- Bioinformatics - prediction of protein functions and functional networks
- Plasticity in pain mechanisms
- molecular neurobiology
Displaying 50 most recent publications. For the full list please visit UCL Discovery
- Dickenson AH (2013) Commentary on: Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain. Neurosci Lett. 10.1016/j.neulet.2013.09.069.
- Gilron I,Jensen TS,Dickenson AH (2013) Combination pharmacotherapy for management of chronic pain: from bench to bedside. Lancet Neurol. 10.1016/S1474-4422(13)70193-5.
- Eijkelkamp N,Linley JE,Torres JM,Bee L,Dickenson AH,Gringhuis M,Minett MS,Hong GS,Lee E,Oh U,Ishikawa Y,Zwartkuis FJ,Cox JJ,Wood JN (2013) A role for Piezo2 in EPAC1-dependent mechanical allodynia. Nat Commun, 4, 1682. 10.1038/ncomms2673.
- Hirsch SJ,Dickenson AH (2013) Morphine sensitivity of spinal neurons in the chronic constriction injury neuropathic rat pain model. Neurosci Lett. 10.1016/j.neulet.2013.10.007.
- Patel R,Bauer CS,Nieto-Rostro M,Margas W,Ferron L,Chaggar K,Crews K,Ramirez JD,Bennett DL,Schwartz A,Dickenson AH,Dolphin AC (2013) α2δ-1 Gene Deletion Affects Somatosensory Neuron Function and Delays Mechanical Hypersensitivity in Response to Peripheral Nerve Damage. J Neurosci, 33(42), 16412 - 16426. 10.1523/JNEUROSCI.1026-13.2013.
- Burnham LJ,Dickenson AH (2013) The antinociceptive effect of milnacipran in the monosodium iodoacetate model of osteoarthritis pain and its relation to changes in descending inhibition. J Pharmacol Exp Ther, 344(3), 696 - 707. 10.1124/jpet.112.199489.
- Tesfaye S,Boulton AJ,Dickenson AH (2013) Mechanisms and management of diabetic painful distal symmetrical polyneuropathy. Diabetes Care, 36(9), 2456 - 2465. 10.2337/dc12-1964.
- Sikandar S,Dickenson AH (2013) II. No need for translation when the same language is spoken. Br J Anaesth, 111(1), 3 - 6. 10.1093/bja/aet210.
- Sikandar S,Ronga I,Iannetti GD,Dickenson AH (2013) Neural coding of nociceptive stimuli-from rat spinal neurones to human perception. Pain. 10.1016/j.pain.2013.03.041.
- Currie GL,Delaney A,Bennett MI,Dickenson AH,Egan KJ,Vesterinen HM,Sena ES,Macleod MR,Colvin LA,Fallon MT (2013) Animal models of bone cancer pain: systematic review and meta-analyses. Pain, 154(6), 917 - 926. 10.1016/j.pain.2013.02.033.
- Sikandar S,Patel R,Patel S,Sikander S,Bennett DL,Dickenson AH (2013) Genes, molecules and patients--emerging topics to guide clinical pain research. Eur J Pharmacol, 716(1-3), 188 - 202. 10.1016/j.ejphar.2013.01.069.
- Rahman W,Dickenson AH (2013) Voltage gated sodium and calcium channel blockers for the treatment of chronic inflammatory pain. Neurosci Lett. 10.1016/j.neulet.2013.08.004.
- Minett MS,Nassar MA,Clark AK,Passmore G,Dickenson AH,Wang F,Malcangio M,Wood JN (2012) Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. Nat Commun, 3, 791. 10.1038/ncomms1795.
- O'Neill J,Brock C,Olesen AE,Andresen T,Nilsson M,Dickenson AH (2012) Unravelling the mystery of capsaicin: a tool to understand and treat pain. Pharmacol Rev, 64(4), 939 - 971. 10.1124/pr.112.006163.
- Gonçalves L,Dickenson AH (2012) Asymmetric time-dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation. Eur J Neurosci, 36(9), 3204 - 3213. 10.1111/j.1460-9568.2012.08235.x.
- Neziri AY,Dickenmann M,Scaramozzino P,Andersen OK,Arendt-Nielsen L,Dickenson AH,Curatolo M (2012) Effect of intravenous tropisetron on modulation of pain and central hypersensitivity in chronic low back pain patients. Pain, 153(2), 311 - 318. 10.1016/j.pain.2011.10.008.
- Passmore GM,Reilly JM,Thakur M,Keasberry VN,Marsh SJ,Dickenson AH,Brown DA (2012) Functional significance of M-type potassium channels in nociceptive cutaneous sensory endings. Front Mol Neurosci, 5, 63. 10.3389/fnmol.2012.00063.
- Thakur M,Rahman W,Hobbs C,Dickenson AH,Bennett DL (2012) Characterisation of a peripheral neuropathic component of the rat monoiodoacetate model of osteoarthritis. PLoS One, 7(3), e33730. 10.1371/journal.pone.0033730.
- Sikandar S,Dickenson AH (2012) Visceral pain: the ins and outs, the ups and downs. Curr Opin Support Palliat Care, 6(1), 17 - 26. 10.1097/SPC.0b013e32834f6ec9.
- Sikandar S,Bannister K,Dickenson AH (2012) Brainstem facilitations and descending serotonergic controls contribute to visceral nociception but not pregabalin analgesia in rats. Neurosci Lett, 519(1), 31 - 36. 10.1016/j.neulet.2012.05.009.
- Marchand F,D'Mello R,Yip PK,Calvo M,Muller E,Pezet S,Dickenson AH,McMahon SB (2011) Specific involvement of atypical PKCζ/PKMζ in spinal persistent nociceptive processing following peripheral inflammation in rat. Mol Pain, 7, 86. 10.1186/1744-8069-7-86.
- Dickenson AH,Baron R (2011) Descending controls: insurance against pain? Pain, 152(12), 2677 - 2678. 10.1016/j.pain.2011.07.003.
- D'Mello R,Marchand F,Pezet S,McMahon SB,Dickenson AH (2011) Perturbing PSD-95 interactions with NR2B-subtype receptors attenuates spinal nociceptive plasticity and neuropathic pain. Mol Ther, 19(10), 1780 - 1792. 10.1038/mt.2011.42.
- Neziri AY,Scaramozzino P,Andersen OK,Dickenson AH,Arendt-Nielsen L,Curatolo M (2011) Reference values of mechanical and thermal pain tests in a pain-free population. Eur J Pain, 15(4), 376 - 383. 10.1016/j.ejpain.2010.08.011.
- Bannister K,Sikandar S,Bauer CS,Dolphin AC,Porreca F,Dickenson AH (2011) Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. Anesthesiology, 115(1), 144 - 152. 10.1097/ALN.0b013e31821f6545.
- Rahman W,Bannister K,Bee LA,Dickenson AH (2011) A pronociceptive role for the 5-HT2 receptor on spinal nociceptive transmission: an in vivo electrophysiological study in the rat. Brain Res, 1382, 29 - 36. 10.1016/j.brainres.2011.01.057.
- Bee LA,Bannister K,Rahman W,Dickenson AH (2011) Mu-opioid and noradrenergic α(2)-adrenoceptor contributions to the effects of tapentadol on spinal electrophysiological measures of nociception in nerve-injured rats. Pain, 152(1), 131 - 139. 10.1016/j.pain.2010.10.004.
- Sikandar S,Dickenson AH (2011) Pregabalin modulation of spinal and brainstem visceral nociceptive processing. Pain, 152(10), 2312 - 2322. 10.1016/j.pain.2011.06.020.
- Bannister K,Dickenson AH (2010) Opioid hyperalgesia. Curr Opin Support Palliat Care, 4(1), 1 - 5. 10.1097/SPC.0b013e328335ddfe.
- Kaan TK,Yip PK,Patel S,Davies M,Marchand F,Cockayne DA,Nunn PA,Dickenson AH,Ford AP,Zhong Y,Malcangio M,McMahon SB (2010) Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats. Brain, 133(9), 2549 - 2564. 10.1093/brain/awq194.
- Neziri AY,Andersen OK,Petersen-Felix S,Radanov B,Dickenson AH,Scaramozzino P,Arendt-Nielsen L,Curatolo M (2010) The nociceptive withdrawal reflex: Normative values of thresholds and reflex receptive fields EUR J PAIN, 14(2). 10.1016/j.ejpain.2009.04.010.
- Asante CO,Wallace VC,Dickenson AH (2010) Mammalian target of rapamycin signaling in the spinal cord is required for neuronal plasticity and behavioral hypersensitivity associated with neuropathy in the rat. J Pain, 11(12), 1356 - 1367. 10.1016/j.jpain.2010.03.013.
- Bauer CS,Rahman W,Tran-van-Minh A,Lujan R,Dickenson AH,Dolphin AC (2010) The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo. Biochem Soc Trans, 38(2), 525 - 528. 10.1042/BST0380525.
- Asante CO,Dickenson AH (2010) Descending serotonergic facilitation mediated by spinal 5-HT3 receptors engages spinal rapamycin-sensitive pathways in the rat. Neurosci Lett, 484(2), 108 - 112. 10.1016/j.neulet.2010.08.024.
- Bauer CS,Nieto-Rostro M,Rahman W,Tran-Van-Minh A,Ferron L,Douglas L,Kadurin I,Sri Ranjan Y,Fernandez-Alacid L,Millar NS,Dickenson AH,Lujan R,Dolphin AC (2009) The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin. J Neurosci, 29(13), 4076 - 4088. 10.1523/JNEUROSCI.0356-09.2009.
- Nguyen D,Deng P,Matthews EA,Kim DS,Feng GP,Dickenson AH,Xu ZC,Luo ZD (2009) Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity MOL PAIN, 5. 10.1186/1744-8069-5-6.
- Harvey VL,Dickenson AH (2009) Behavioural and electrophysiological characterisation of experimentally induced osteoarthritis and neuropathy in C57Bl/6 mice. Mol Pain, 5, 18. 10.1186/1744-8069-5-18.
- Neziri AY,Andersen OK,Dickenson AH,Arendt-Nielsen L,Curatolo M (2009) Interaction of gender with age for pressure pain thresholds in pain-free humans SWISS MED WKLY, 139(41-42), 5S - 5S.
- Bannister K,Bee LA,Dickenson AH (2009) Preclinical and early clinical investigations related to monoaminergic pain modulation. Neurotherapeutics, 6(4), 703 - 712. 10.1016/j.nurt.2009.07.009.
- Vonsy JL,Ghandehari J,Dickenson AH (2009) Differential analgesic effects of morphine and gabapentin on behavioural measures of pain and disability in a model of osteoarthritis pain in rats. Eur J Pain, 13(8), 786 - 793. 10.1016/j.ejpain.2008.09.008.
- Bee LA,Dickenson AH (2009) The importance of the descending monoamine system for the pain experience and its treatment. F1000 Med Rep, 1. 10.3410/M1-83.
- Maratou K,Wallace VCJ,Hasnie FS,Okuse K,Hosseini R,Jina N,Blackbeard J,Pheby T,Orengo C,Dickenson AH,McMahon SB,Rice ASC (2009) Comparison of dorsal root ganglion gene expression in rat models of traumatic and HIV-associated neuropathic pain EUR J PAIN, 13(4), 387 - 398. 10.1016/j.ejpain.2008.05.011.
- Bauer C,Nieto-Rostro M,Rahman W,Tran-Van-Minh A,Ferron L,Douglas L,Kadurin I,Sri Ranjan Y,Fernandez-Alacid L,Millar NS,Dickenson AH,Lujan R,Dolphin AC (2009) The increased trafficking of the calcium channel subunit α2δ-1 to presynaptic terminals in neuropathic pain is inhibited by the α2δ ligand pregabalin. Journal of Neuroscience, 29, 4076 - 4088.
- Rahman W,Bauer CS,Bannister K,Vonsy J-L,Dolphin AC,Dickenson AH (2009) Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain. Molecular Pain, 5, 45.
- Asante CO,Wallace VC,Dickenson AH (2009) Formalin-induced behavioural hypersensitivity and neuronal hyperexcitability are mediated by rapid protein synthesis at the spinal level. Mol Pain, 5, 27. 10.1186/1744-8069-5-27.
- Harvey VL,Caley A,Müller UC,Harvey RJ,Dickenson AH (2009) A Selective Role for alpha3 Subunit Glycine Receptors in Inflammatory Pain. Front Mol Neurosci, 2, 14. 10.3389/neuro.02.014.2009.
- Bee LA,Dickenson AH (2009) Effects of lacosamide, a novel sodium channel modulator, on dorsal horn neuronal responses in a rat model of neuropathy. Neuropharmacology, 57(4), 472 - 479. 10.1016/j.neuropharm.2009.06.021.
- D'Mello R,Dickenson AH (2008) Spinal cord mechanisms of pain. Br J Anaesth, 101(1), 8 - 16. 10.1093/bja/aen088.
- Rahman W,Suzuki R,Hunt SP,Dickenson AH (2008) Selective ablation of dorsal horn NK1 expressing cells reveals a modulation of spinal alpha2-adrenergic inhibition of dorsal horn neurones Neuropharmacology, 54(8), 1208 - 1214. 10.1016/j.neuropharm.2008.03.014.
- Rahman W,D'Mello R,Dickenson AH (2008) Peripheral Nerve Injury-Induced Changes in Spinal alpha(2)-Adrenoceptor-Mediated Modulation of Mechanically Evoked Dorsal Horn Neuronal Responses. The Journal of Pain, 9(4), 350 - 359.
BiographyBuilding a team of motivated, communicative, proactive and skilled pain researchers has lead to almost 275 publications and an h index of 61. Informing and educating on pain mechanisms and analgesic targets, translation from preclinical to patients and public engagement. Involved in many advisory boards and spoken around the world (what a privilege) at Pain Congresses. Many collaborative projects and aiming to be approachable and affable to all.
- 1977: Doctor of Philosophy, National Institute for Medical Research
- 1974: Bachelor of Science (Honours), University of Reading
- Anxiety disorders
- Behavioural analysis
- Bioinformatic analysis
- Central Pain syndrome
- Electrophysiological recording techniques
- Genetic manipulation (including knockout/knockin)
- Low back pain
- Neural signalling
- Neuroanatomical approaches
- Neurobiological studies on pain and analgesia
- Neuropathy Pain - chronic
- Pain-related behaviour analysis
- Sensory transduction
- Spinal cord