Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

1. Smithen M,Elustondo PA,Winkfein R,Zakharian E,Abramov AY,Pavlov E (2013) Role of polyhydroxybutyrate in mitochondrial calcium uptake. Cell Calcium. 10.1016/j.ceca.2013.04.006.
2. Suwanjang W,Abramov AY,Govitrapong P,Chetsawang B (2013) Melatonin attenuates dexamethasone toxicity-induced oxidative stress, calpain and caspase activation in human neuroblastoma SH-SY5Y cells. J Steroid Biochem Mol Biol. 10.1016/j.jsbmb.2013.04.008.
3. Bartolome F,Wu HC,Burchell VS,Preza E,Wray S,Mahoney CJ,Fox NC,Calvo A,Canosa A,Moglia C,Mandrioli J,Chiò A,Orrell RW,Houlden H,Hardy J,Abramov AY,Plun-Favreau H (2013) Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels. Neuron, 78(1), 57 - 64. 10.1016/j.neuron.2013.02.028.
4. Holmström KM,Marina N,Baev AY,Wood NW,Gourine AV,Abramov AY (2013) Signalling properties of inorganic polyphosphate in the mammalian brain. Nat Commun, 4, 1362. 10.1038/ncomms2364.
5. Suwanjang W,Holmström KM,Chetsawang B,Abramov AY (2013) Glucocorticoids reduce intracellular calcium concentration and protects neurons against glutamate toxicity. Cell Calcium, 53(4), 256 - 263. 10.1016/j.ceca.2012.12.006.
6. Kamynina AV,Filatova MP,Koroev DO,Abramov AY,Volpina OM (2013) Antibodies to synthetic fragment 95-123 of the prion protein protect neurons and astrocytes from beta-amyloid toxicity RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 39(2), 113 - 120. 10.1134/S1068162013020076.
7. Vaarmann A,Kovac S,Holmström KM,Gandhi S,Abramov AY (2013) Dopamine protects neurons against glutamate-induced excitotoxicity. Cell Death Dis, 4, e455. 10.1038/cddis.2012.194.
8. Wood-Kaczmar A,Deas E,Wood NW,Abramov AY (2013) The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease. Adv Exp Med Biol, 961, 241 - 249. 10.1007/978-1-4614-4756-6_20.
9. Duberley KE,Abramov AY,Chalasani A,Heales SJ,Rahman S,Hargreaves IP (2013) Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment. J Inherit Metab Dis, 36(1), 63 - 73. 10.1007/s10545-012-9511-0.
10. Kamynina AV,Holmström KM,Koroev DO,Volpina OM,Abramov AY (2013) Acetylcholine and antibodies against the acetylcholine receptor protect neurons and astrocytes against beta-amyloid toxicity. Int J Biochem Cell Biol, 45(4), 899 - 907. 10.1016/j.biocel.2013.01.011.
11. Baev AY,Holmstrom KM,Levitskaya YV,Abramov AY (2013) Role of Polyphosphate in Mitochondria: From Modification of Energy Metabolism to Induction of the Cell Death BIOPHYSICAL JOURNAL, 104(2), 660A - 660A.
12. Kovac S,Abramov AY,Walker MC (2013) Energy depletion in seizures: anaplerosis as a strategy for future therapies. Neuropharmacology, 69, 96 - 104. 10.1016/j.neuropharm.2012.05.012.
13. Domijan AM,Kovac S,Abramov AY (2012) Impact of fumonisin B1 on glutamate toxicity and low magnesium-induced seizure activity in neuronal primary culture. Neuroscience, 202, 10 - 16. 10.1016/j.neuroscience.2011.12.005.
14. Cremades N,Cohen SI,Deas E,Abramov AY,Chen AY,Orte A,Sandal M,Clarke RW,Dunne P,Aprile FA,Bertoncini CW,Wood NW,Knowles TP,Dobson CM,Klenerman D (2012) Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell, 149(5), 1048 - 1059. 10.1016/j.cell.2012.03.037.
15. Gandhi S,Vaarmann A,Yao Z,Duchen MR,Wood NW,Abramov AY (2012) Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease. PLoS One, 7(5), e37564. 10.1371/journal.pone.0037564.
16. Gandhi S,Abramov AY (2012) Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev, 2012, 428010. 10.1155/2012/428010.
17. Plun-Favreau H,Burchell VS,Holmström KM,Yao Z,Deas E,Cain K,Fedele V,Moisoi N,Campanella M,Miguel Martins L,Wood NW,Gourine AV,Abramov AY (2012) HtrA2 deficiency causes mitochondrial uncoupling through the F₁F₀-ATP synthase and consequent ATP depletion. Cell Death Dis, 3, e335. 10.1038/cddis.2012.77.
18. Charlesworth G,Plagnol V,Holmström KM,Bras J,Sheerin UM,Preza E,Rubio-Agusti I,Ryten M,Schneider SA,Stamelou M,Trabzuni D,Abramov AY,Bhatia KP,Wood NW (2012) Mutations in ANO3 cause dominant craniocervical dystonia: ion channel implicated in pathogenesis. Am J Hum Genet, 91(6), 1041 - 1050. 10.1016/j.ajhg.2012.10.024.
19. Kamynina AV,Holmstrom KM,Koroev DO,Volpina OM,Abramov AY (2012) Anti-peptide antibodies to synthetic fragments of alpha7-subunit acetylcholine receptor or prion protein protect cells against beta-amyloid toxicity JOURNAL OF PEPTIDE SCIENCE, 18, S136 - S136.
20. Ding S,Riddoch-Contreras J,Abramov AY,Qi Z,Duchen MR (2012) Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca2+ transients and nitric oxide. J Muscle Res Cell Motil, 33(5), 327 - 337. 10.1007/s10974-012-9318-5.
21. Ding S,Riddoch-Contreras J,Abramov AY,Qi Z,Duchen MR (2012) Erratum to: Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca(2+) transients and nitric oxide. J Muscle Res Cell Motil, 33(5), 339. 10.1007/s10974-012-9327-4.
22. Kovac S,Domijan AM,Walker MC,Abramov AY (2012) Prolonged seizure activity impairs mitochondrial bioenergetics and induces cell death. J Cell Sci, 125(Pt 7), 1796 - 1806. 10.1242/jcs.099176.
23. Abramov AY,Duchen MR (2011) Measurements of threshold of mitochondrial permeability transition pore opening in intact and permeabilized cells by flash photolysis of caged calcium. Methods Mol Biol, 793, 299 - 309. 10.1007/978-1-61779-328-8_19.
24. Ionov M,Burchell V,Klajnert B,Bryszewska M,Abramov AY (2011) Mechanism of neuroprotection of melatonin against beta-amyloid neurotoxicity. Neuroscience, 180, 229 - 237. 10.1016/j.neuroscience.2011.02.045.
25. Domijan AM,Abramov AY (2011) Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis--implication to mechanism of cell toxicity. Int J Biochem Cell Biol, 43(6), 897 - 904. 10.1016/j.biocel.2011.03.003.
26. Abeti R,Abramov AY,Duchen MR (2011) Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death. Brain, 134(Pt 6), 1658 - 1672. 10.1093/brain/awr104.
27. Abramov AY,Gegg M,Grunewald A,Wood NW,Klein C,Schapira AH (2011) Bioenergetic consequences of PINK1 mutations in Parkinson disease. PLoS One, 6(10), e25622. 10.1371/journal.pone.0025622.
28. Kovac S,Domijan A,Walker MC,Abramov AY (2011) PROLONGED SEIZURE ACTIVITY IMPAIRS MITOCHONDRIAL BIOENERGETICS AND INDUCES CELL DEATH EPILEPSIA, 52, 85 - 85.
29. Yao Z,Gandhi S,Burchell VS,Plun-Favreau H,Wood NW,Abramov AY (2011) Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease. J Cell Sci, 124(Pt 24), 4194 - 4202. 10.1242/jcs.088260.
30. Deas E,Plun-Favreau H,Gandhi S,Desmond H,Kjaer S,Loh SH,Renton AE,Harvey RJ,Whitworth AJ,Martins LM,Abramov AY,Wood NW (2011) PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet, 20(5), 867 - 879. 10.1093/hmg/ddq526.
31. Abramov AY,Ionov M,Pavlov E,Duchen MR (2011) Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer's disease. Aging Cell, 10(4), 595 - 603. 10.1111/j.1474-9726.2011.00685.x.
32. Kovac S,Domijan AM,Walker MC,Abramov AY (2011) ROLE OF MITOCHONDRIAL FUNCTION IN SEIZURE-INDUCED NEURONAL CELL DEATH EPILEPSIA, 52, 45 - 45.
33. Vaarmann A,Gandhi S,Abramov AY (2010) Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase. J Biol Chem, 285(32), 25018 - 25023. 10.1074/jbc.M110.111450.
34. Abramov AY,Smulders-Srinivasan TK,Kirby DM,Acin-Perez R,Enriquez JA,Lightowlers RN,Duchen MR,Turnbull DM (2010) Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations. Brain, 133(Pt 3), 797 - 807. 10.1093/brain/awq015.
35. Pavlov E,Aschar-Sobbi R,Campanella M,Turner RJ,Gómez-García MR,Abramov AY (2010) Inorganic polyphosphate and energy metabolism in mammalian cells. J Biol Chem, 285(13), 9420 - 9428. 10.1074/jbc.M109.013011.
36. Burchell VS,Gandhi S,Deas E,Wood NW,Abramov AY,Plun-Favreau H (2010) Targeting mitochondrial dysfunction in neurodegenerative disease: Part I. Expert Opin Ther Targets, 14(4), 369 - 385. 10.1517/14728221003652489.
37. Burchell VS,Gandhi S,Deas E,Wood NW,Abramov AY,Plun-Favreau H (2010) Targeting mitochondrial dysfunction in neurodegenerative disease: Part II. Expert Opin Ther Targets, 14(5), 497 - 511. 10.1517/14728221003730434.
38. Ahluwalia J,Tinker A,Clapp LH,Duchen MR,Abramov AY,Pope S,Nobles M,Segal AW (2010) The large-conductance Ca2+-activated K+ channel is essential for innate immunity (Retraction of vol 427, pg 853, 2004) NATURE, 468(7320), 122 - 122. 10.1038/nature09562.
39. Vaarmann A,Gandhi S,Gourine AV,Abramov AY (2010) Novel pathway for an old neurotransmitter: dopamine-induced neuronal calcium signalling via receptor-independent mechanisms. Cell Calcium, 48(2-3), 176 - 182. 10.1016/j.ceca.2010.08.008.
40. Abramov AY,Duchen MR (2010) Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons. Biochimica et Biophysica Acta (BBA) - General Subjects. 10.1016/j.bbagen.2009.08.002.
41. Igosheva N,Abramov AY,Poston L,Eckert JJ,Fleming TP,Duchen MR,McConnell J (2010) Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PLoS One, 5(4), e10074. 10.1371/journal.pone.0010074.
42. Gandhi S,Wood-Kaczmar A,Yao Z,Plun-Favreau H,Deas E,Klupsch K,Downward J,Latchman DS,Tabrizi SJ,Wood NW,Duchen MR,Abramov AY (2009) PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death Molecular Cell, 33(5), 627 - 638. 10.1016/j.molcel.2009.02.013.
43. Cantley J,Selman C,Shukla D,Abramov AY,Forstreuter F,Esteban MA,Claret M,Lingard SJ,Clements M,Harten SK,Asare-Anane H,Batterham RL,Herrera PL,Persaud SJ,Duchen MR,Maxwell PH,Withers DJ (2009) Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. Journal of Clinical Investigation, 119(1), 125 - 135. 10.1172/JCI26934.
44. Gandhi S,Wood-Kaczmar A,Wood NW,Duchen MR,Abramov AY (2009) PINK1 associated Parkinson's disease is caused by neuronal vulnerability to calcium induced cell death MOVEMENT DISORDERS, 24, S33 - S33.
45. Galkin A,Abramov AY,Frakich N,Duchen MR,Moncada S (2009) Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury? J Biol Chem, 284(52), 36055 - 36061. 10.1074/jbc.M109.054346.
46. Wood-Kaczmar A,Gandhi S,Yao Z,Abramov AY,Miljan EA,Keen G,Stanyer L,Hargreaves I,Klupsch K,Downward J,Mansfield L,Jat P,Taylor J,Heales S,Duchen MR,Latchman D,Tabrizi SJ,Wood NW (2009) PINK1 is necessary for long term survival and mitochondrial function in primary human dopaminergic neurons JOURNAL OF NEUROCHEMISTRY, 109, 301 - 302.
47. Abramov AY,Duchen MR (2008) Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1777(7-8), 953 - 964. 10.1016/j.bbabio.2008.04.017.
48. Campanella M,Casswell E,Chong S,Farah Z,Wieckowski MR,Abramov AY,Tinker A,Duchen MR (2008) Regulation of mitochondrial structure and function by the F₁F_o-ATPase inhibitor protein, IF₁. Cell Metabolism, 8(1), 13 - 25. 10.1016/j.cmet.2008.06.001.
49. Wood-Kaczmar A,Gandhi S,Yao Z,Abramov ASY,Miljan EA,Keen G,Stanyer L,Hargreaves I,Klupsch K,Deas E,Downward J,Mansfield L,Jat P,Taylor J,Heales S,Duchen MR,Latchman DL,Tabrizi SJ,Wood NW (2008) PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons PLoS ONE, 3(6), e2455. 10.1371/journal.pone.0002455.
50. Abramov AY,Kasymov VA,Zinchenko VP (2008) Beta amyloid activates synthesis of nitric oxide in hyppocampal astrocytes and causes death of neurons BIOL MEMBRANY, 25(1), 11 - 17.