Our Division recognizes that successful academic careers increasingly start with an entry-level fellowship. We have an excellent track record in recruiting promising scientists at this level and providing them with the scientific environment and mentorship that they need to become successful independent investigators. We remain committed to this process.
If you are eligible for fellowship schemes, for example, from the
Wellcome Trust or the Medical Research Council, and would
like to apply for a fellowship to work as an independent investigator in
Infection and Immunity at UCL, send a research proposal and a CV to g.towers (at) ucl.ac.uk
If you are interested in a postdoctoral position in our lab, please email your CV and a statement of interest to g.towers (at) ucl.ac.uk. Any postdoctoral positions will be advertised on this site, the infection and immunity site and the main UCL vacancies site.
The research project aims to understand the molecular details of the relationship between human immunodeficiency virus and the human cell autonomous innate immune system. We have recently shown that HIV recruits specific host factors that cloak the virus allowing it to avoid triggering innate DNA sensors within infected cells. When these host factor interactions are disturbed cytoplasmic DNA sensors, for example cGAS, are triggered, interferon is produced and viral replication is abrogated. The host factors prevent DNA sensor activation by regulating viral DNA synthesis and nuclear import (Rasaiyaah, J. et al Nature 2013).
These positions, funded by an ERC Advanced Award, will investigate the molecular details of the cloaking process and the cell autonomous innate immune response that is unleashed when HIV is uncloaked. We expect to take a collaborative approach, working closely with protein crystallographers, chemists and immunologists, to solve the details of innate evasion strategies employed by HIV and related primate lentiviruses. We also aim to understand the relationship between triggering innate responses and priming the adaptive immune response. The HIV cloaking mechanism can be inhibited pharmacologically and we will explore the therapeutic approaches that this work suggests. We share lab space with clinical virologists with research programmes in HIV drug resistance and HIV and tuberculosis immunology.
The posts are available from February 2014 and are for three years in the first instance and maybe extended to five years depending on the progress of the project.
Closing Date 23/12/13
For further information and to apply please visit the main UCL vacancies site, job ref: 1387672
If you are interested in studying for a PhD in our lab, available schemes include:
The MRC/UCL Centre for Medical Molecular Virology is now accepting applications for the 2014-15 academic session intake of ‘Bench to Bedside’ studentships. Details of how to apply for these fully funded studentships are available on the Divisional website, on the Centre’s Website and also on Find-a-PhD.com website. Applications close on Friday 20 December 2013. Interviews will be on 4 & 7 February 2014.
Page last modified on 09 dec 13 17:14 by Jane Lorna Elizabeth Turner