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Systems Biology of Ageing

At the simplest level, the flow of information from genes to proteins is essential for the development, function and maintenance of living organisms. Genomic and proteomic approaches have identified many of the components and interactions involved in this process. What is less well understood is how variability or “noise” in this process, such as alterations in gene regulation, stochastic expression levels between cells, and errors such as mutations or mis-folding in DNA, RNA and proteins, contributes to ageing.

The aim of this research theme is to address questions such as:

  • What are the changes in gene expression noise as a function of environmental stress and ageing?
  • What are the impacts of any increased noise on the information flow from genotype to phenotype?
  • How are cellular quality control systems (DNA/RNA/protein) modulated during stress and ageing?
  • Can too much noise have advantages during some situations, e.g. to survive a stressful condition?
  • A range of complementary approaches, including ‘omics, models systems (yeast, worm, fly), bioinformatics and theoretical modelling are used to address this research theme.

This grouping interacts with the Institute of Health Ageing (Director: Prof Dame Linda Partridge), an interdisciplinary centre of excellence for research on the biology of ageing and ageing-related diseases.

Page last modified on 28 oct 10 11:13


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