Events and News
News
Systems Biology Journal club has restarted for the this term. First meeting 29 September >>more
Information about the BBSRC e-Learning for Systems Approaches programme now available >>more
New PhD Programme
UCL has developed a new Interdisciplinary PhD Programme in bioscience and bioengineering. The programme covers all levels of biology, from molecules through to cells and whole animal physiology, and provides training in cutting edge techniques, including bioengineering, data analysis, computational and mathematical modelling, imaging, structural biology and systems approaches >>more
Recent Publications
Jennifer Rohn and Buzz Baum (LMCB) "Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype"
Jennifer Rohn and Buzz Baum (LMCB) "Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration"
Systems Biology of Ageing
At the simplest level, the flow of information from genes to proteins is essential for the development, function and maintenance of living organisms. Genomic and proteomic approaches have identified many of the components and interactions involved in this process. What is less well understood is how variability or “noise” in this process, such as alterations in gene regulation, stochastic expression levels between cells, and errors such as mutations or mis-folding in DNA, RNA and proteins, contributes to ageing.
The aim of this research theme is to address questions such as:
- What are the changes in gene expression noise as a function of environmental stress and ageing?
- What are the impacts of any increased noise on the information flow from genotype to phenotype?
- How are cellular quality control systems (DNA/RNA/protein) modulated during stress and ageing?
- Can too much noise have advantages during some situations, e.g. to survive a stressful condition?
- A range of complementary approaches, including ‘omics, models systems (yeast, worm, fly), bioinformatics and theoretical modelling are used to address this research theme.
This grouping interacts with the Institute of Health Ageing (Director: Prof Dame Linda Partridge), an interdisciplinary centre of excellence for research on the biology of ageing and ageing-related diseases.
Page last modified on 28 oct 10 11:13
