Coltop

Surgery and Interventional Science



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The two main areas of research are:

Reconstructive Transplantation / CTA

This research group has set up the first reconstructive transplantation programme in the UK and are pioneers in the filed. The areas of study are facial transplantation, hand transplantation, combined hand and face transplantation as well emerging transplants of other tissues. It has an established clinical research programme with long standing international collaborations.

Tissue Engineering / Nanotechnology

This group is at the forefront of translational tissue engineering/nanotechnology research. It produced the first in-human tracheal tissue-engineered transplant in collaboration with the Karolinska Institute and also the first in-human tissue-engineered arterial bypass graft. A first in-human nasal construct will be carried out later this year. Further tissues such as ear and dermis/skin are also in production.

  • Development of auricular reconstruction using nanocomposite and stem cells
  • Development of nasal reconstruction using nanocomposite and stem cells
  • Development of synthetic face using nanocomposite and stem cells
  • Development of conduit to regulate nerve using peptide modified nanocomposite materials and stem cells
  • Extraction of stem cells from fat tissue
  • Development of lymphatic drainage system using nanocomposite
  • Fillers for plastic surgery applications using nanocomposite and stem cells
  • Nanoparticles for diagnostic and treatment of cancer
  • Fluorescent quantum dots for assessment of flap perfusion
  • Development of POSS-PCU based nanocomposite in craniofacial orbital reconstruction
  • Reconstruction of vermillion and lip using nanocomposite materials
  • Creation of neo-hair follicle
  • Breast reconstruction
  • Skin tissue engineering

Logos Royal Free London - NHS Royal National Orthopaedic Hospital - NHS University College London Hospitals - NHS UCL Institute of Biomedical Engineering NPIMR