Hollow Organ Tissue Engineering Translational Programme

UCL Hollow Organ Tissue Engineering Translational Programme Working Group Members are listed here


UCL Hollow Organ Tissue Engineering Translational Programme

Step towards creating intestine transplant using patient's own cells


8 February 2012: UCL Dr Paolo de Coppi and colleagues have reported a new protocol that creates a natural intestinal scaffold, as a base for developing functional intestinal tissue.  This work, published online in Biomaterials on 3 February 2012, represents a step towards creating intestine transplant using patient’s own cells.

Read "A rat decellularized small bowel scaffold that preserves villus-crypt architecture for intestinal regeneration"

First synthetic windpipe transplant 

7 July 2011: UCL Professor Alex Seifalian designed and developed an artificial windpipe using a novel nanocomposite polymer; it was then coated in the patient's stem cells and implanted in a 36 year-old cancer patient.  The surgery was performed by Prof. Paolo Macchiarini (who holds a UCL Honorary appointment) at the Karolinska University Hospital in Stockholm, Sweden.

The results of this proof of concept study were published online in The Lancet on 24 November 2011
Read "Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study"

New collaboration funded by the MRC Translational Stem Cell Programme

New interdisciplinary collaborations developed as a result of the Hollow Organ Tissue Engineering Translational Programme have led to the RegenVox -Stem-cell based, tissue-engineered laryngeal replacement project being funded by the MRC Translational Stem Cell Programme (start date: 1st April 2011).  The project is led by Martin Birchall with Mark Lowdell, Alex Seifalian, Sam Janes, Chris Mason and Paolo Macchiarini.

Stem cell voice box transplant trials could begin in 2013

Speaking at the UK National Stem Cell Network annual science meeting in York on 30 March 2011, Prof. Martin Birchall announced that the first clinical trials for stem cell voice transplants could begin in 2013, thanks to a million pounds provided by the Medical Research Council.  Dr Rob Buckle, Head of Regenerative Medicine at the MRC said: "Regenerative medicine is a key priority for the MRC and Professor Birchall’s project could have a huge impact on how transplants are carried out in the future.”
More at the Medical Research Council.

Tracheal Transplant

Previous meetings of the UCL Hollow Organ Tissue Engineering Translational Programme

For papers and reports from previous UCL Hollow Organ Tissue Engineering Translational Programme meetings, click on the links below


Since 1st April 2011, regular meetings take place as part of the RegenVox - Stem-cell based, tissue-engineered laryngeal replacement project, funded by the MRC Translational Stem Cell Research Programme

Special Seminars held on:

  • Monday 12 September 2011: Invited speaker: Dr. Thomas W. Gilbert, Departments of Surgery and Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, USA. Title:“Regenerative Medicine Strategies for Trachea Repair”. Venue: Gavin De Beer Lecture Theatre, Anatomy building, Gower St.
  • Tuesday 19 July 2011: Invited speaker: Dr Tracy Grikscheit, Division of Pediatric Surgery Keck School of Medicine, USC Saban Research Institute Childrens Hospital Los Angeles, USA.  Title: "Tissue engineering the intestine: the role of the intestinal stem cell niche."  Venue: Leolin Price Lecture Theatre, UCL Institute of Child Health
  • Tuesday 28 June 2011: Invited speaker: Dr Shay Soker, Wake Forest Institute of Regenerative Medicine, Winston Salem, NC, USA Title: "Regenerative Medicine: Hopes and Challenges for Clinical Translation" Venue: Doctor mess meeting room 4th floor, Great Ormond Street Hospital
  • Friday 18 June 2010: Invited Speaker: Dr. Casey Childers, Wake Forrest Institute for Regenerative Medicine, North Carolina, USATitle: "The effects of stem cell therapy on the protein deficiencies that cause degenerative muscle diseases" Venue: Main Seminar Room, Dept of Surgery, 9th floor of the Royal Free Hospital
  • Thursday 13 May 2010
  • Monday 6 July 2009 - Agenda
  • Monday 29 June 2009 - Agenda
  • Wednesday 24 June 2009
  • Thursday 18 June 2009
  • Tuesday 9 June 2009 - Agenda
  • Monday 9 March 2009 - Agenda

Page last modified on 15 jun 12 10:15