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Perkins Group

steveperkinsupdated  

Prof Steve Perkins

I run the Structural Immunology Group at UCL in which we work with the complement proteins and antibodies of immunology. I am best known for the development of a novel constrained modelling method for neutron and X-ray scattering and analytical ultracentrifugation to determine their solution structures. We also employ other biophysical techniques to study molecular interactions, and also develop interactive web sites of mutations in our proteins.

Patricia Fitton  

Dr Patricia Fitton

I am interested in novel therapeutic reagents which incorporate short complement repeat domains. A structural understanding of their interactions with its ligands should highlight its potential effect in regulating complement-mediated diseases.

David Wright  

Dr David Wright

I am a scientific software developer and computational biologist. The focus of my work is the development of new tools to facilitate the modelling of protein structures from small angle scattering data.

Ruodan Nan  

Dr Ruodan Nan

My research interests are the mechanism of complement activation and regulation which are important in health and disease. I currently work on the structures of MBL and MASP-2 in the lectin pathway of complement system, and am interested also in Factor H and C3 of complement.

Danny Gale  

Dr Danny Gale

Daniel Gale is a nephrologist with a clinical and research interest in genetic causes of kidney disease, including CFHR5 nephropathy, which results from a defect of complement alternative pathway regulation and which is endemic in Cyprus. On-going projects aim to improve understanding of the pathophysiology of CFHR5 nephropathy and to investigate other families with unexplained inherited kidney disease in order to uncover the genes responsible.

Keying Li  

Dr Keying Li

My area of research currently focuses on the aggregation propensity of antibodies involved with biopharmaceuticals. These are being identified by a combination of analytical ultracentrifugation, X-ray scattering, size-exclusion chromatography and an Avacta Optim.

Pavithra Rallapalli  

Pavithra Rallapalli

I work on protein mutations in the coagulation cascade.  My main focus is to correlate the protein sequences and structures with their functional interactions, also keeping in mind their evolution.  I also work on databases of these proteins, including the update and maintenance of our existing databases for FIX, FVIII and FXI.

Lucy Rayner  

Lucy Rayner

My area of research involves the solution structures of human antibodies (specifically the IgG subclasses) using X-ray and neutron scattering with analytical ultracentrifugation and constrained modelling.  A detailed understanding of antibody solution structures is required to explore their full potential as biopharmaceuticals.

Elizabeth Rodriguez  

Elizabeth Rodriguez

I am studying the several forms of human complement protein C3 to identify their conformational properties during complement activation and their relationship to disease. For this, I employ a combination of neutron and X-ray solution scattering, analytical ultracentrifugation and surface plasmon resonance.

Ka Wai Fung  

Ka Wai Fung

Age-related macular degeneration (AMD) begins with the accumulation of sub-retinal pigment epithelial deposits (sRPEd).  Complement factor H (CFH) is linked to the formation of sRPEd.  I am studying conformational changes in CFH when this binds to heparin using dual polarization interferometry and surface plasmon resonance methods.

Po Jung Pao  

Po-Jung Pao

My project is to study potential mechanisms leading to the formation of sub-retinal pigment epithelial deposits (sRPEds) which are a hallmark of age-related macular degeneration (AMD). I focus on the role of zinc in this process, including biochemical studies of the complement proteins and live RPE cell cultures to model an “in vivo” like environment for the formation of deposits.

orla  

Orla Dunne

I am studying the interactions between complement Factor H and two of its ligands, namely C-reactive protein and C3d. I am currently based at the Institut Laue- Langevin, Grenoble, France, wherer I am making deuterated proteins in order to perform neutron scattering experiments, alongside X-ray scattering and analytical ultracentrifugation experiments.

Nilufar Kadkhodayi-Kholghi  

Nilufar Kadkhodayi-Kholghi

I am studying the CFHR5 proteins involved with CFHR5 nephropathy in order to unravel their contributions to renal disease using a combination of biophysical and modelling approaches.

Jayesh Gor  

Jayesh Gor Facilities Manager

I manage the Molecular Interactions Facility which is comprised of two Beckman-Coulter XL-I analytical ultracentrifuges, a Biacore X100 surface plasmon resonance instrument and a Farfield dual polarisation interferometer. While the main users are from the group, I also help outside users to run experiments in the Facility.

Bill Fleming updated  

Bill Fleming  Assistant to Professor Perkins

Professor Perkins is deaf, so I may be the first point of contact if you telephone or visit. 

I administer the Moodle on-line teaching website for the courses that Professor Perkins offers.  I also answer any queries or problems the students may have.  I will up-date this website as well.