Perkins Group

sperkins_finalcopy   Professor Stephen Perkins
I run the Structural Immunology Group at UCL.
I am best known for the development of a novel constrained modelling method for neutron and X-ray scattering and analytical ultracentrifugation to determine solution structures for the complement proteins of innate immunity (factor H) and the human antibody classes.  We also employ surface plasmon resonance and a dual polarisation interferometer.  We study the consequences of amino acid mutations on the function of medically important proteins which include the development of interactive web sites.

Dr Ruodan Nan          Post-doc
BSc Pharmacy, PR China;
MSc in Molecular & Medical Microbiology;
PhD on Complement Factor H

I'm interested in a protein called factor H (FH), a major regulator of complement activation in innate immunity.  A polymorphism in FH, Tyr402His, is a high risk factor for age-related macular degeneration.  My PhD project is focused on studying the effect of this polymorphism on the self-association properties of FH alone and in the presence of metals. 

Keying   Dr Keying Li               Post-doc 
BSc  Computer Science & Genetics;
PhD on Complement Receptor Type 2
My area of research involves the solution structure of Complement receptor type 2 with its ligands.  Complement receptor type 2 (CR2.CD21) is one of the regulators of the complement activation (RCA) gene family.  The CR2 ligands include C3 cleavage fragments, CD23 (a low affinity receptor for IgE), IFN-alpha, and the coat glycoprotein gp350 of EBV.
pavi-3_photo   Pavithra Rallapalli PhD student
B.Tech Bioinformatics, India
I work on protein mutations in the complement and coagulation cascades.  My main focus is to correlate the protein sequences and structures with their functional interactions, also keeping in mind their evolution.  I also work on databases of these proteins, including the update and maintenance of our existing database for FH, MCP and FI, that for FXI, and that for the vitamin-K dependent proteases.
lucy   Lucy Rayner            PhD student
BSc Biochemistry
My area of research involves the solution structures of human antibodies (specifically the IgG subclasses) using X-ray scattering and analytical ultracentrifugation.  The study of antibody solution structures is required to explore their full potential as biopharmaceuticals.
Liz_Rod_final   Elizabeth Rodriguez PhD Student
BSc Biochemistry
I am a PhD student, studying complement component C3c and C3d to see if these two fragments interact with each other, using Xray solution scattering, AUC and neutron scattering.  I will also be unravelling the conformational and other changes in IgA antibodies that lead to renal disease.
gary   Ka Wai Fung               PhD Student
BSc Chemistry
Age-related degeneration (AMD) begins with the accumulation of sub-rentinal pigment epithelial deposits (sRPEd).  The nature and mechanisms of how this deposit is formed is not fully understood.  Complement factor H (CFH) is linked to the formation of sRPEd.  My PhD research involves determination of the conformational change of CFH during binding with heparin by using Dual polarization interferometry and surface plasmon resonance.
orla   Orla Dunne                  PhD Student
I am studying the interaction between C-reactive protein (CRP) and complement factor H (CFH).  Complement factor H is a regulator of the alternative pathway of complement activation, while CRP is an acute phase protein involved in the classical pathway of complement activation.  The focus of my PhD is to characterise the complexes formed between CRP and CFH, principally using neutron scattering of deuterated protein.
Bill Fleming  

Bill Fleming  Assistant to Professor Perkins

Professor Perkins is deaf, so I may be the first point of contact if you telephone or visit. 

I will administer the Moodle on-line teaching website for the courses that Professor Perkins offers.  I also answer any queries or problems the students may have.  I will up-date this website as well.