Prof Rhona Mirsky

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Name: Rhona Mirsky Email: r.mirsky@ucl.ac.uk
Title: Prof Tel:
Department: Cell & Developmental Biology Fax:
Position: Principle Research Associate Address: Anatomy Building, UCL, Gower Street, London, WC1E 6BT
Research Domain: Basic Life Sciences, Neuroscience, Personalised Medicine, Stem Cells & Regenerative Medicine (Frontier Disciplines) Web Page: Personal Web Page

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Research Description

We are interested in Schwann cells, the glial cells of peripheral nerves. These cells provide signals that during development are required for neuronal survival, and which are essential for the integrity of peripheral nerves in the adult. They also make myelin sheaths around axons that are needed for the normal conduction of nerve impulsesa dn provide vital support for small axons in unmyelinated nerve fibres. Importantly, in damaged nerves, Schwann cells guide regrowing axons back towards their targets and make nerve repair possible.
The striking PNS response to injury rests on the plasticity of adult Schwann cells and their ability to transit between differentiation states.  The injury response represents  a natural reprogramming of differentiated cells to generate a distinct Schwann cell state specialized to promote axon growth and nerve regeneration.  This response is dependent on the expression of the transcription factor c-Jun in Schwann cells. But the Schwann cell response is also a major problem in the common inherited and acquired peripheral neuropathies during which dedifferentiation and demyelination occur. It is possible that common mechanisms exist between the Schwann cell response to direct nerve injury and the inujry response observed in neuropathies.


The work of the laboratory addresses a group of interlocking issues in Schwann cell biology.


(i) The response of Schwann cells to injury and genetic disease, including

the process of demyelination and control of axon regrowth and nerve

repair.


(ii) Control of myelination,


(iii) Early Schwann cell development and the biology of the Schwann cell precursor and how this relates to the repair phenotype generated after injury.


To learn about these events, we study molecular signalling between neurons and glia, examine how transcription factors control differentiation and repair programmes and analyse intracellular signalling cascades that regulate survival, proliferation, myelination, demyelination and aoxonal regeneration. We use cells from rats, and normal and transgenic and knockout mice, and a variety of molecular, biochemical, cell biological and cell culture techniques.

Research Activities

Glial development in the PNS

Models of Neurodegenerative Disease

Neurovascular copatterning

Perinatal Neuroscience

Schwann cell development and differentiation

Education Description

I supervise the work of PhD, MSc and BSc students in thier thesis work and laboratory projects.

UCL Collaborators

Prof Nikki Robertson; Dr Mark Cooper; Prof Sebastian Brandner; Prof Donald Peebles; Prof Kristjan Jessen; Dr Paul Simons; Prof Mary Reilly; Prof Patrick Anderson; Prof Christiana Ruhrberg; Prof Justin Hsuan

External Collaborators

Publications

    2013

    • Kipanyula MJ, Woodhoo A, Rahman M, Payne D, Jessen KR, Mirsky R (2013). Calcineurin-nuclear factor of activated t cells regulation of Krox-20 expression in Schwann cells requires elevation of intracellular cyclic AMP. JOURNAL OF NEUROSCIENCE RESEARCH, 91(1), 105 - 115. doi:10.1002/jnr.23131
    • Jessen K, Mirsky R (2013). NERVE REPAIR DEPENDS ON C-JUN DRIVEN SCHWANN CELL TRANSDIFFERENTIATION TO GENERATE A SPECIALIZED REPAIR CELL IN INJURED NERVES..
    • Mirsky R, Arthur-Farraj P, Latouche M, Wilton D, Quintes S, Chabrol E, Woodhoo A, Jenkins B, Turmaine M, Behrens A, Raivich G, Jessen K (2013). SCHWANN CELL C-JUN IS ESSENTIAL FOR SUCCESSFUL PERIPHERAL NERVE REGENERATION.
    • Arthur-Farraj P, Latouche M, Wilton DK, Quintes S, Chabrol E, Woodhoo A, Jenkins B, Turmaine M, Behrens A, Raivich G, Mirsky R, Jessen KR (2013). SCHWANN CELL C-JUN IS ESSENTIAL FOR SUCCESSFUL NERVE REGENERATION.
    • Wilton D, Malgapo K, Benito C, Gomis C, Shen J, Meijer D, Feltri L, Wrabetz L, Behrens A, Mirsky R, Jessen K (2013). NOVEL INTERACTIONS BETWEEN THE C-JUN AND NOTCH SIGNALLING PATHWAYS REGULATE THE SCHWANN CELL RESPONSE TO PERIPHERAL NERVE INJURY.

    2012

    • Yang DP, Kim J, Syed N, Tung YJ, Bhaskaran A, Mindos T, Mirsky R, Jessen KR, Maurel P, Parkinson DB, Kim HA (2012). p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination.. J Neurosci, 32(21), 7158 - 7168. doi:10.1523/JNEUROSCI.5812-11.2012
    • Iruarrizaga-Lejarreta M, Varela-Rey M, Lozano JJ, Fernández-Ramos D, Rodríguez-Ezpeleta N, Embade N, Lu SC, van der Kraan PM, Blaney Davidson EN, Gorospe M, Mirsky R, Jessen KR, Aransay AM, Mato JM, Martínez-Chantar ML, Woodhoo A (2012). The RNA-binding protein human antigen R controls global changes in gene expression during Schwann cell development.. J Neurosci, 32(14), 4944 - 4958. doi:10.1523/JNEUROSCI.5868-11.2012
    • Fontana X, Hristova M, Da Costa C, Patodia S, Thei L, Makwana M, Spencer-Dene B, Latouche M, Mirsky R, Jessen KR, Klein R, Raivich G, Behrens A (2012). c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling.. J Cell Biol, 198(1), 127 - 141. doi:10.1083/jcb.201205025
    • Doddrell RDS, Dun X-P, Moate RM, Jessen KR, Mirsky R, Parkinson DB (2012). Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor. GLIA, 60(9), 1269 - 1278. doi:10.1002/glia.22346
    • Jessen KR, Arthur-Farraj, PJ , Latouche, M , Wilton, DK , Quintes, S , Chabrol, E , Banerjee, A , Woodhoo, A , Jenkins, B , Rahman, M , Turmaine, M , Wicher, GK , Mitter, R , Greensmith, L , Behrens, A , Raivich, G , Mirsky, R (2012). c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration. Neuron, 75(4), 633 - 647. doi:10.1016/j.neuron.2012.06.021

    2011

    • Hutton EJ, Carty L, Laurá M, Houlden H, Lunn MP, Brandner S, Mirsky R, Jessen K, Reilly MM (2011). c-Jun expression in human neuropathies: a pilot study.. J Peripher Nerv Syst, 16(4), 295 - 303. doi:10.1111/j.1529-8027.2011.00360.x
    • Arthur-Farraj P, Wanek K, Hantke J, Davis CM, Jayakar A, Parkinson DB, Mirsky R, Jessen KR (2011). Mouse schwann cells need both NRG1 and cyclic AMP to myelinate.. Glia, 59(5), 720 - 733. doi:10.1002/glia.21144

    2010

    • Jessen KR, Mirsky R (2010). Control of Schwann cell myelination.. F1000 Biol Rep, 2, - . doi:10.3410/B2-19
    • Hutton EJ, Carty L, Laura M, Houlden H, Lunn MP, Brandner S, Mirsky R, Jessen K, Reilly MM (2010). C-Jun expression in human neuropathies: a pilot study.

    2009

    • Mirsky R, Jessen KR (2009). TRANSCRIPTIONAL REGULATORS THAT CONTROL SCHWANN CELL DEVELOPMENT, DEDIFFERENTIATION AND NERVE REPAIR.
    • Latouche M, Wilton D, Arthur-Farraj P, Dacosta C, Mitter R, Turmaine M, Raivich G, Behrens A, Mirsky R, Jessen KR (2009). SCHWANN CELL C-JUN REGULATES GLIAL SUPPORT FOR SURVIVAL OF PNS NEURONS AFTER INJURY.
    • Jessen KR, Arthur-Farraj P, Latouch-Hartman M, Wilton D, Bherens A, Raivich G, Mirsky R (2009). THE CONTROL OF NERVE DEVELOPMENT, PATHOLOGY AND REPAIR BY c-JUN AND NOTCH IN SCHWANN CELLS.
    • Arthur-Farraj P, Makwana M, Wilton D, Latouche-Hartman M, Acosta A, Cuthill D, Bherens A, Mirsky R, Raivich G, Jessen KR (2009). IN INJURED NERVES, C-JUN IN SCHWANN CELLS CONTROLS DEMYELINATION, NEURONAL SURVIVAL, AXONAL RE-GROWTH AND FUNCTIONAL RECOVERY.
    • Hantke J, Wilton D, Latouche-Hartman M, Baas F, Mirsky R, Jessen KR (2009). BEHAVIOURAL PROFILING OF A MOUSE MODEL OF CMT1A WITH 3 TO 4 COPIES OF PMP22.
    • Parkinson DB, Heupel K, Mirsky R, Jessen KR (2009). REGULATION OF SCHWANN CELL DIFFERENTIATION AND PROLIFERATION BY THE PAX-3 TRANSCRIPTION FACTOR.
    • Hantke J, Wilton D, Latouche M, Baas F, Mirsky R, Jessen KR (2009). A CMT1A MOUSE MODEL WITH 3 TO 4 COPIES OF PMP22.
    • Wilton D, Arthur-Farraj P, Latouche M, Turmaine M, Behrens A, Mirsky R, Raivich G, Jessen K (2009). SCHWANN CELL C-JUN IS ESSENTIAL FOR PERIPHERAL NERVE REGENERATION.
    • Woodhoo A, Alonso MB, Droggiti A, Turmaine M, D'Antonio M, Parkinson DB, Wilton DK, Al-Shawi , R , Simons P, Shen J, Guillemot F, Radtke F, Meijer D, Feltri ML, Wrabetz L, Mirsky R, Jessen KR (2009). Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity.. Nature Neuroscience, 12, 839 - 847. doi:10.1038/nn.2323

    2008

    • Jessen KR, Mirsky R, Arthur-Farraj P, Woodhoo A (2008). Molecular mechanisms in Schwann cells that control axon growth and nerve repair.
    • Mirsky R, Woodhoo A, Parkinson DB, Arthur-Farraj P, Bhaskaran A, Jessen KR (2008). Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation. Journal of the Peripheral Nervous System, 13(2), 122 - 135. doi:10.1111/j.1529-8027.2008.00168.x
    • Agudo M, Woodhoo A, Webber D, Mirsky R, Jessen KR, McMahon SB (2008). Schwann cell precursors transplanted into the injured spinal cord multiply, integrate and are permissive for axon growth. Glia, 56(12), 1263 - 1270. doi:10.1002/glia.20695
    • Jessen KR, Mirsky R, Salzer J (2008). Introduction. Schwann cell biology.. Glia, 56(14), 1479 - 1480. doi:10.1002/glia.20779
    • Jessen KR, Mirsky R (2008). Negative regulation of myelination: relevance for development, injury, and demyelinating disease.. Glia, 56(14), 1552 - 1565. doi:10.1002/glia.20761
    • Parkinson DB, Bhaskaran A, Arthur-Farraj P, Noon LA, Woodhoo A, Lloyd AC, Feltri ML, Wrabetz L, Behrens A, Mirsky R, Jessen KR (2008). c-Jun is a negative regulator of myelination. The Journal of Cell Biology, 181(4), 625 - 637. doi:10.1083/jcb.200803013

    2007

    • Bhaskaran A, Parkinson D, Mirsky R, Jessen KR (2007). Schwann cell myelination is inhibited by c-jun and p38 mitogen activated protein kinase pathways. NEURON GLIA BIOL, 2, S42 - S42.
    • Davis C, Mirsky R, Jessen K (2007). A dual role for STAT(3) in Schwann cells: protection from apoptosis and promotion of differentiation. NEURON GLIA BIOL, 2, S44 - S44.
    • Arthur-Farraj P, Bhaskaran A, Parkinson D, Turmaine M, Feltri L, Wrabetz L, Behrens A, Mirsky R, Lessen K (2007). The transcription factor c-Jun, controls Schwann cell demyelination and dedifferentiation after peripheral nerve injury. NEURON GLIA BIOL, 2, S133 - S133.
    • Parkinson D, Bhaskaran A, Arthur-Farraj P, Noon L, Lloyd A, Behrens A, Feltri L, Wrabetz L, Mirsky R, Lessen K (2007). A central role for c-Jun in regulating the differentiation of Schwann cells. NEURON GLIA BIOL, 2, S38 - S38.
    • Mirsky R, Woodhoo A, Parkinson DB, Banerjee A, Sharghi-Namini S, Jessen KR (2007). GBS/CIDP foundation international lecture - Signals that control Schwann cell development and myelination.
    • Sahni V, Mirsky R, Lessen KR (2007). Cell-intrinsic default generation of Schwann cells from Schwann cell precursors. NEURON GLIA BIOL, 2, S52 - S52.
    • Mirsky R, Jessen KR (2007). Early events in Schwann cell development. In Armati PJ (Ed.), The Biology of Schwann Cells – Development, Differentiation and Immunomodulation (pp. 13 - 36). : Cambridge University Press.
    • Woodhoo A, Sahni V, Gilson J, Setzu A, Franklin RJM, Blakemore WF, Mirsky R, Jessen KR (2007). Schwann cell precursors: a favourable cell for myelin repair in the Central Nervous System. Brain, 130(8), 2175 - 2185. doi:10.1093/brain/awm125
    • Woodhoo A, Alonso MBD, Mirsky R, Lessen KR (2007). Regulation of the immature Schwann cell phenotype by Notch signalling. NEURON GLIA BIOL, 2, S13 - S14.

    2006

    • D Antonio M, Droggiti A, Feltri ML, Roes J, Wrabetz L, Mirsky R, Jessen KR (2006). TGFß type II receptor signaling controls Schwann cell death and proliferation in developing nerves. Journal of Neuroscience, 26(33), 8417 - 8427. doi:10.1523/JNEUROSCI.1578-06.2006
    • Spiegel I, Adamsky K, Eisenbach M, Eshed Y, Spiegel A, Mirsky R, Scherer SS, Peles E (2006). Identification of novel cell-adhesion molecules in peripheral nerves using a signal-sequence trap. NEURON GLIA BIOL, 2, 27 - 38. doi:10.1017/S1740925X0600007X
    • D Antonio M, Michalovich D, Paterson M, Droggiti A, Woodhoo A, Mirsky R, Jessen KR (2006). Gene profiling and bioinformatic analysis of Schwann cell embryonic development and myelination. Glia, 53(5), 501 - 515.
    • Kazakova N, Li H, Mora A, Jessen K, Mirsky R, Richardson WD, Smith HK (2006). A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes. Developmental Biology, 297, 1 - 13. doi:10.1016/j.ydbio.2006.03.020
    • Sharghi-Namini S, Turmaine M, Meier C, Sahni V, Umehara F, Jessen KR, Mirsky R (2006). The structural and functional integrity of peripheral nerves depends on the glial-derived signal desert hedgehog. Journal of Neuroscience, 26, 6364 - 6376. doi:10.1523/JNEUROSCI.0157-06.2006
    • Umehara F, Bajestan SN, Sharghi-Namini S, Jessen KR, Mirsky R, Osame M (2006). Desert hedgehog-patched 2 expression in peripheral nerves during Wallerian degeneration and regeneration.
    • Jessen KR, Mirsky R, Woodhoo A, Parkison D, Haskaran A (2006). Interactions between Notch, c-Jun and Krox-20 in the control of early Schwann cell development and myelination. doi:10.1016/j.ijdevneu.2006.09.043
    • Wanner IB, Guerra NK, Mahoney J, Kumar A, Wood PM, Mirsky R, Jessen KR (2006). Role of N-cadherin in Schwann cell precursors of growing nerves. Glia, 54, 439 - 459.
    • Arthur-Farraj P, Mirsky R, Parkinson DB, Jessen KR (2006). A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy. Neurobiology of Disease, 24, 159 - 169.
    • Bajestan SN, Umehara F, Shirahama Y, Itoh K, Sharghi-Namini S, Jessen KR, Mirsky R, Osame M (2006). Desert hedgehog-patched 2 expression in peripheral nerves during Wallerian degeneration and regeneration. Journal of Neurobiology, 66(3), 243 - 255.

    2005

    • Parkinson DB, Bhaskaran A, Mirsky R, Jessen KR (2005). Regulation of the myelinating phenotype of Schwann cells by Krox-20.
    • Woodhoo A, Duran Alonso M, Parkinson DB, Mirsky R, Jessen KR (2005). Factors affecting the early life of a Schwann cell.
    • Bajestan SN, Umehara F, Itoh K, Sharghi-Namini S, Jessen KR, Mirsky R, Osame M (2005). Desert hedgehog-patched2 expression in peripheral nerves during Wallerian degeneration and regeneration.
    • Parkinson DB, Bhaskaran A, Mirsky R, Jessen KR (2005). Krox-20 inhibits the Jun-n-terminal kinase/C-Jun pathway to regulate the myelinating phenotype of Schwann cells.
    • Jessen KR, Mirsky R, Woodhoo A, Parkinson D, Bhaskaran A (2005). The function of Notch and stress kinase signals in early Schwann cell development.
    • Mirsky R, Jessen KR (2005). Molecular signaling in Schwann cell development. In Dyck PJ, Thomas PK (Ed.), Peripheral Neuropathy (pp. - ). : Elsevier Press.
    • Jessen KR, Mirsky R (2005). The origin and development of glial cells in peripheral nerves. Nature Reviews Neuroscience, 6, 671 - 682. doi:10.1038/nrn1746
    • Jessen KR, Mirsky R (2005). The Schwann cell lineage. In Kettenmann H, Ransom B (Ed.), Neuroglia (pp. 85 - 100). : Oxford University Press.

    2004

    • Meintanis S, Thomaidou D, Jessen KR, Mirsky R, Matsas R (2004). Novel method for studying myelination in vivo reveals that EDTA is a potent inhibitor of myelin protein and mRNA expression during development of the rat sciatic nerve. Glia, 48, 132 - 144.
    • Woodhoo A, Dean CH, Droggiti A, Mirsky R, Jessen KR (2004). The trunk neural crest and its early glial derivatives: a study of survival responses, developmental schedules and autocrine mechanisms. Molecular and Cellular Neuroscience, 25, 30 - 41. doi:10.1016/j.mcn.2003.09.006
    • Jessen KR, Mirsky R (2004). The developmental biology of the Schwann cell. In Uziel G, Taroni F (Ed.), Hereditary Leukoencephalopathies and Demyelinating Neuropathies in Children (pp. 23 - 35). : John Libbey Eurotext.
    • Jessen KR, Mirsky R (2004). Schwann cell development. In Lazzarini RA (Ed.), Myelin Biology and Disorders, Volume 1 (pp. 329 - 370). : Elsevier Academic Press.
    • Alonso MB, Zoidl G, Taveggia C, Bosse F, Zoidl C, Rahman M, Parmantier E, Dean CH, Harris BS, Wrabetz L, Müller HW, Jessen KR, Mirsky R (2004). Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system.. Journal of Biological Chemistry, 279, 25653 - 25664. doi:10.1074/jbc.M400415200
    • Parkinson DB, Bhaskaran A, Droggiti A, Dickinson S, D'Antonio M, Mirsky R, Jessen KR (2004). Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death. The Journal of Cell Biology, 164(3), 385 - 394. doi:10.1083/jcb.200307132

    2003

    • Parkinson DB, Dickinson S, Bhaskaran A, Kinsella MT, Brophy PJ, Sherman DL, Sharghi-Namini S, Duran Alonso MB, Mirsky R, Jessen KR (2003). Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells. Molecular and Cellular Neuroscience, 23, 13 - 27.
    • Jessen KR, Mirsky R, Parkinson D, Bhaskaran A, Kazakova N (2003). Signals that regulate Schwann cell generation and myelination.

    2002

    • Jessen KR, Mirsky R (2002). Signals that determine Schwann cell identity. Journal of Anatomy, 200, 367 - 376.
    • Mirsky R, Jessen KR, Brennan A, Parkinson D, Dong Z, Meier C, Parmantier E, Lawson D (2002). Schwann cells as regulators of nerve development. Journal of Physiology (Paris), 96, 17 - 24.
    • Alonso MBD, Zoidl G, Jaegle M, Harris BS, Meijer D, Jessen KR, Mirsky R (2002). A possible role for the putative transcription factor ZPF-57 in embryonic Schwann cell development. GLIA, , S13 - S14.
    • Parkinson DB, Dickinson S, Bhaskaran A, Kinsella MT, Brophy PJ, Sherman DL, Sharghi-Namini S, Duran Alonso MB, Jessen KR, Mirsky R (2002). Krox 20 activates a set of complex changes in Schwann cells that characterize myelination.
    • Parkinson DB, Langner K, Sharghi Namini S, Jessen KR, Mirsky R (2002). Beta-neuregulin and autocrine mediated survival of Schwann cells requires activity of Ets family transcription factors. Molecular and Cellular Neuroscience, 20, 154 - 167. doi:10.1006/mcne.2002.1109
    • Kasakova N, Calle E, Mirsky R, Jessen KR (2002). Glial development from the neural crest. GLIA, , S14 - S14.
    • Bhaskaran A, Parkinson DB, von Hertzen L, Jessen KR, Mirsky R (2002). Krox-20 protects Schwann cells from TGF-beta mediated cell death. GLIA, , S73 - S73.
    • Tofaris GK, Patterson PH, Jessen KR, Mirsky R (2002). Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF. Journal of Neuroscience, 22, 6696 - 6703.

    2001

    • Stewart HJS, Brennan A, Rahman M, Zoidl G, Mitchell PJ, Jessen KR, Mirsky R (2001). Developmental regulation and overexpression of the transcription factor AP-2, a potential regulator of the timing of Schwann cell generation. European Journal of Neuroscience, 14, 363 - 372.
    • Mirsky R, Parkinson DB, Dong Z, Meier C, Calle E, Brennan A, Topilko P, Harris BS, Stewart HJS, Jessen KR (2001). Regulation of genes involved in Schwann cell development and differentiation. Progress in Brain Research, 132, 3 - 11.
    • Lee MJ, Calle E, Brennan A, Ahmed S, Sviderskaya E, Jessen KR, Mirsky R (2001). In early development of the rat mRNA for the major myelin protein P0 is expressed in nonsensory areas of the embryonic inner ear, notochord, enteric nervous system, and olfactory ensheathing cells. Developmental Dynamics, 222, 40 - 51.
    • Mirsky R, Jessen KR (2001). Embryonic and early postnatal development of Schwann cells. In Jessen KR, Richardson WD (Ed.), Glial Cell Development: basic principles and clinical relevance (pp. 1 - 20). : Oxford University Press.
    • Meintanis S, Thomaidou D, Jessen KR, Mirsky R, Matsas R (2001). The neuron-glia signal beta-neuregulin promotes Schwann cell motility via the MAPK pathway. Glia, 34, 39 - 51.
    • Parkinson DB, Dong Z, Bunting H, Whitfield J, Meier C, Marie H, Mirsky R, Jessen KR (2001). Transforming growth factor β (TGFβ) mediates Schwann cell death in vitro and in vivo: examination of c-Jun activation, interactions with survival signals, and the relationship of TGFβ mediated death to Schwann cell differentiation. Journal of Neuroscience, 21, 8572 - 8585.
    • Bhaskaran A, Parkinson DB, von Hertzen L, Jessen KR, Mirsky R (2001). Krox-20 protects Schwann cells from TGF beta mediated cell death. MOL BIOL CELL, 12, 28A - 28A.

    2000

    • Brennan A, Dean CH, Zhang AL, Cass DT, Mirsky R, Jessen KR (2000). Endothelins control the timing of Schwann cell generation in vitro and in vivo.. Dev Biol, 227(2), 545 - 557. doi:10.1006/dbio.2000.9887
    • Brennan A, Dean CH, Zhang AL, Cass DT, Mirsky R, Jessen KR (2000). Endothelins control the timing of Schwann cell generation in vitro and in vivo.. Developmental Biology, 227, 545 - 557.

    1999

    • Meier C, Parmantier E, Brennan A, Mirsky R, Jessen KR (1999). Developing Schwann cells acquire the ability to survive without axons by establishing an autocrine circuit involving insulin-like growth factor, neurotrophin-3, and platelet-derived growth factor-BB.. J Neurosci, 19(10), 3847 - 3859.
    • Mirsky R, Jessen KR (1999). The neurobiology of Schwann cells. Brain Pathology, 9, 293 - 311.
    • Parmantier E, Lynn B, Lawson D, Turmaine M, Sharghi Namini S, Chakrabarti L, McMahon AP, Jessen KR, Mirsky R (1999). Schwann cell-derived Desert Hedgehog controls the development of peripheral nerve sheaths. Neuron, 23, 713 - 724.
    • Meier C, Parmantier E, Brennan A, Mirsky R, Jessen KR (1999). Developing Schwann cells acquire the ability to survive without axons by establishing an autocrine circuit involving IGF, NT-3 and PDGF-BB. Journal of Neuroscience, 19, 3847 - 3859.
    • Jessen KR, Mirsky R (1999). Developmental regulation in the Schwann cell lineage.. Adv Exp Med Biol, 468, 3 - 12.
    • Jessen KR, Meier C, Mirsky R (1999). Why do Schwann cells survive in the absence of axons?. Annals of the New York Academy of Sciences, 883, 109 - 115.
    • Dong Z, Sinanan A, Parkinson D, Parmantier E, Mirsky R, Jessen KR (1999). Schwann cell development in embryonic mouse nerves. Journal of Neuroscience Research, 56, 334 - 348.
    • Jessen KR, Mirsky R (1999). Schwann cells and their precursors emerge as major regulators of nerve development. Trends in Neurosciences, 22, 402 - 410.
    • Mirsky R, Parmantier E, McMahon AP, Jessen KR (1999). Schwann cell-derived desert hedgehog signals nerve sheath formation. Annals of the New York Academy of Sciences, 883, 196 - 202.

    1998

    • Tabernero A, Stewart HJS, Jessen KR, Mirsky R (1998). The Neuron-Glia Signal beta Neuregulin Induces Sustained CREB Phosphorylation on Ser-133 in Cultured Rat Schwann Cells.. Mol Cell Neurosci, 10(5/6), 309 - 322.
    • Jessen KR, Mirsky R (1998). Origin and early development of Schwann cells. Microscopy Research and Technique, 41, 393 - 402.
    • Meintanis S, Matsas R, Greensmith L, Mirsky R, Jessen KR (1998). An in vivo method to study inhibitors and enhancers of myelination during development of the rat sciatic nerve.. EUR J NEUROSCI, 10, 340 - 340.
    • Tabernero A, Stewart HJS, Jessen KR, Mirsky R (1998). The neuron-glia signal á neuregulin induces sustained CREB phosphorylation on Ser-133 in cultured rat Schwann Cells. Molecular and Cellular Neuroscience, 10, 309 - 322.

    1997

    • Lee M, Brennan A, Blanchard A, Zoidl G, Dong Z, Tabernero C, Zoidl C, Dent MAR, Jessen KR, Mirsky R (1997). Po is constitutively expressed in the rat neural crest and embryonic nerves and is negatively and positively regulated by axons to generate non-myelin-forming and myelin-forming Schwann cells, respectively. Molecular and Cellular Neuroscience, 8, 336 - 350.
    • Stewart HJS, Zoidl G, Rossner M, Brennan A, Zoidl C, Nave K, Mirsky R, Jessen KR (1997). Helix-loop-helix proteins in Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development. Journal of Neuroscience Research, 50, 684 - 701.
    • Jessen KR, Mirsky R, Dong Z, Brennan A (1997). Developmental regulation of Schwann cell precursors and Schwann cell generation. In Devon RM, Doucette R, Juurlink BHJ, Nazarali AJ, Schreyer DJ, Verge VMK (Ed.), Cell Biology and Pathology of Myelin: Evolving Biological Concepts and Therapeutic Approaches (pp. - ). : Plenum Publishing Corporation.
    • Stewart HJS, Turner D, Jessen KR, Mirsky R (1997). Expression and regulation of à1á1 integrin in Schwann cells. Journal of Neurobiology, 33, 914 - 928.
    • Zoidl G, Blanchard A, Zoidl C, Dong Z, Brennan A, Parmantier E, Mirsky R, Jessen KR (1997). Identification of transcriptionally regulated mRNAs from mouse Schwann cell precursors using modified RNA fingerprinting methods. Journal of Neuroscience Research, 49, 32 - 42.
    • Jessen KR, Mirsky R (1997). Embryonic Schwann cell development: the biology of Schwann cell precursors and early Schwann cells. Journal of Anatomy, 191, 501 - 505.
    • Dong Z, Dean C, Walters JE, Mirsky R, Jessen KR (1997). Response of Schwann cells to mitogens in vitro is determined by pre-exposure to serum, time in vitro and developmental age. Glia, 20, 219 - 230.

    1996

    • Mirsky R, Jessen KR (1996). Schwann cell development, differentiation and myelination.. Curr Opin Neurobiol, 6(1), 89 - 96.
    • Stewart HJ, Bradke F, Tabernero A, Morrell D, Jessen KR, Mirsky R (1996). Regulation of rat Schwann cell Po expression and DNA synthesis by insulin-like growth factors in vitro.. Eur J Neurosci, 8(3), 553 - 564.
    • Blanchard AD, Sinanan A, Parmantier E, Zwart R, Broos L, Meijer D, Meier C, Jessen KR, Mirsky R (1996). Oct-6 (SCIP/Tst-1) is expressed in Schwann cell precursors, embryonic Schwann cells, and postnatal myelinating Schwann cells: comparison with Oct-1, Krox-20, and Pax-3.. J Neurosci Res, 46(5), 630 - 640. doi:10.1002/(SICI)1097-4547(19961201)46:5<630::AID-JNR11>3.0.CO;2-0

    1995

    • Gavrilovic J, Brennan A, Mirsky R, Jessen KR (1995). Fibroblast growth factors and insulin growth factors combine to promote survival of rat Schwann cell precursors without induction of DNA synthesis.. Eur J Neurosci, 7(1), 77 - 85.
    • Dong Z, Brennan A, Liu N, Yarden Y, Lefkowitz G, Mirsky R, Jessen KR (1995). Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors.. Neuron, 15(3), 585 - 596.
    • Stewart HJ, Rougon G, Dong Z, Dean C, Jessen KR, Mirsky R (1995). TGF-betas upregulate NCAM and L1 expression in cultured Schwann cells, suppress cyclic AMP-induced expression of O4 and galactocerebroside, and are widely expressed in cells of the Schwann cell lineage in vivo.. Glia, 15(4), 419 - 436. doi:10.1002/glia.440150406
    • Stewart HJ, Curtis R, Jessen KR, Mirsky R (1995). TGF-beta s and cAMP regulate GAP-43 expression in Schwann cells and reveal the association of this protein with the trans-Golgi network.. Eur J Neurosci, 7(8), 1761 - 1772.

    1994

    • MIRSKY R, JESSEN KR (1994). SCHWANN-CELLS - MHC CLASS-II ANTIGEN EXPRESSION, ANTIGEN PRESENTATION AND INTERLEUKIN-1 PRODUCTION. J NEUROCHEM, 62, S118 - S118.
    • Morgan L, Jessen KR, Mirsky R (1994). Negative regulation of the P0 gene in Schwann cells: suppression of P0 mRNA and protein induction in cultured Schwann cells by FGF2 and TGF beta 1, TGF beta 2 and TGF beta 3.. Development, 120(6), 1399 - 1409.
    • Jessen KR, Mirsky R (1994). Neural development. Fate diverted.. Curr Biol, 4(9), 824 - 827.
    • MIRSKY R, MORGAN L, STEWART HJS, JESSEN KR (1994). MOLECULAR SIGNALS RELATED TO MYELINATION IN SCHWANN-CELLS. J NEUROCHEM, 62, S118 - S118.
    • Jessen KR, Brennan A, Morgan L, Mirsky R, Kent A, Hashimoto Y, Gavrilovic J (1994). The Schwann cell precursor and its fate: a study of cell death and differentiation during gliogenesis in rat embryonic nerves.. Neuron, 12(3), 509 - 527.
    • JESSEN KR, MIRSKY R, BRENNAN A (1994). SCHWANN-CELL PRECURSORS IN THE RAT - SURVIVAL AND DEVELOPMENT. J NEUROCHEM, 62, S118 - S118.

    1993

    • Bergsteinsdottir K, Hashimoto Y, Brennan A, Mirsky R, Jessen KR (1993). The effect of three dimensional collagen type I preparation on the structural organization of guinea pig enteric ganglia in culture.. Exp Cell Res, 209(1), 64 - 75. doi:10.1006/excr.1993.1286

    1992

    • Jessen KR, Mirsky R (1992). Schwann cells: early lineage, regulation of proliferation and control of myelin formation.. Curr Opin Neurobiol, 2(5), 575 - 581.

    1991

    • Stewart HJ, Eccleston PA, Jessen KR, Mirsky R (1991). Interaction between cAMP elevation, identified growth factors, and serum components in regulating Schwann cell growth.. J Neurosci Res, 30(2), 346 - 352. doi:10.1002/jnr.490300210
    • Stewart HJ, Eccleston PA, Jessen KR, Mirsky R (1991). Mitogenic response and phenotype of short- and long-term cultured Schwann cells. Relationship to intracellular cAMP levels.. Ann N Y Acad Sci, 633, 537 - 539.
    • Morgan L, Jessen KR, Mirsky R (1991). The effects of cAMP on differentiation of cultured Schwann cells: progression from an early phenotype (04+) to a myelin phenotype (P0+, GFAP-, N-CAM-, NGF-receptor-) depends on growth inhibition.. J Cell Biol, 112(3), 457 - 467.
    • Eccleston PA, Mirsky R, Jessen KR (1991). Spontaneous immortalisation of Schwann cells in culture: short-term cultured Schwann cells secrete growth inhibitory activity.. Development, 112(1), 33 - 42.
    • Jessen KR, Mirsky R (1991). Schwann cell precursors and their development.. Glia, 4(2), 185 - 194. doi:10.1002/glia.440040210
    • Bergsteinsdottir K, Kingston A, Mirsky R, Jessen KR (1991). Rat Schwann cells produce interleukin-1.. J Neuroimmunol, 34(1), 15 - 23.

    1990

    • Jessen KR, Morgan L, Stewart HJ, Mirsky R (1990). Three markers of adult non-myelin-forming Schwann cells, 217c(Ran-1), A5E3 and GFAP: development and regulation by neuron-Schwann cell interactions.. Development, 109(1), 91 - 103.
    • Mirsky R, Dubois C, Morgan L, Jessen KR (1990). 04 and A007-sulfatide antibodies bind to embryonic Schwann cells prior to the appearance of galactocerebroside; regulation of the antigen by axon-Schwann cell signals and cyclic AMP.. Development, 109(1), 105 - 116.
    • Eccleston PA, Collarini EJ, Jessen KR, Mirsky R, Richardson WD (1990). Schwann Cells Secrete a PDGF-like Factor: Evidence for an Autocrine Growth Mechanism involving PDGF.. Eur J Neurosci, 2(11), 985 - 992.

    1989

    • Clemence A, Mirsky R, Jessen KR (1989). Non-myelin-forming Schwann cells proliferate rapidly during Wallerian degeneration in the rat sciatic nerve.. J Neurocytol, 18(2), 185 - 192.
    • Eccleston PA, Bannerman PG, Pleasure DE, Winter J, Mirsky R, Jessen KR (1989). Control of peripheral glial cell proliferation: enteric neurons exert an inhibitory influence on Schwann cell and enteric glial cell DNA synthesis in culture.. Development, 107(1), 107 - 112.
    • Eccleston PA, Mirsky R, Jessen KR (1989). Type I collagen preparations inhibit DNA synthesis in glial cells of the peripheral nervous system.. Exp Cell Res, 182(1), 173 - 185.
    • Eccleston PA, Jessen KR, Mirsky R (1989). Transforming growth factor-beta and gamma-interferon have dual effects on growth of peripheral glia.. J Neurosci Res, 24(4), 524 - 530. doi:10.1002/jnr.490240410

    1988

    • Burnstock G, Mirsky R, Belai A (1988). Reversal of nerve damage in streptozotocin-diabetic rats by acute application of insulin in vitro.. Clin Sci (Lond), 75(6), 629 - 635.

    1987

    • Eccleston PA, Jessen KR, Mirsky R (1987). Control of peripheral glial cell proliferation: a comparison of the division rates of enteric glia and Schwann cells and their response to mitogens.. Dev Biol, 124(2), 409 - 417.
    • Jessen KR, Mirsky R, Morgan L (1987). Axonal signals regulate the differentiation of non-myelin-forming Schwann cells: an immunohistochemical study of galactocerebroside in transected and regenerating nerves.. J Neurosci, 7(10), 3362 - 3369.
    • Eccleston PA, Mirsky R, Jessen KR, Sommer I, Schachner M (1987). Postnatal development of rat peripheral nerves: an immunohistochemical study of membrane lipids common to non-myelin forming Schwann cells, myelin forming Schwann cells and oligodendrocytes.. Brain Res, 432(2), 249 - 256.
    • HILLS JM, JESSEN KR, MIRSKY R (1987). AN IMMUNOHISTOCHEMICAL STUDY OF THE DISTRIBUTION OF ENTERIC GABA-CONTAINING NEURONS IN THE RAT AND GUINEA-PIG INTESTINE. NEUROSCIENCE, 22(1), 301 - 312.
    • Jessen KR, Mirsky R, Morgan L (1987). Myelinated, but not unmyelinated axons, reversibly down-regulate N-CAM in Schwann cells.. J Neurocytol, 16(5), 681 - 688.

    1984

    • MIRSKY R, JESSEN KR (1984). A CELL-SURFACE PROTEIN OF ASTROCYTES, RAN-2, DISTINGUISHES NON-MYELIN-FORMING SCHWANN-CELLS FROM MYELIN-FORMING SCHWANN-CELLS. DEV NEUROSCI-BASEL, 6(6), 304 - 316.

    1981

    • Pruss RM, Mirsky R, Raff MC, Thorpe R, Dowding AJ, Anderton BH (1981). All classes of intermediate filaments share a common antigenic determinant defined by a monoclonal antibody.. Cell, 27(3 Pt 2), 419 - 428.

    1979

    • JESSEN KR, MIRSKY R, DENNISON ME, BURNSTOCK G (1979). GABA MAY BE A NEUROTRANSMITTER IN THE VERTEBRATE PERIPHERAL NERVOUS-SYSTEM. NATURE, 281(5726), 71 - 74.

    1978

    • Raff MC, Mirsky R, Fields KL, Lisak RP, Dorfman SH, Silberberg DH, Gregson NA, Leibowitz S, Kennedy MC (1978). Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture.. Nature, 274(5673), 813 - 816.
    • Fields KL, Brockes JP, Mirsky R, Wendon LM (1978). Cell surface markers for distinguishing different types of rat dorsal root ganglion cells in culture.. Cell, 14(1), 43 - 51.
    • MIRSKY R, WENDON LMB, BLACK P, STOLKIN C, BRAY D (1978). TETANUS TOXIN - CELL-SURFACE MARKER FOR NEURONS IN CULTURE. BRAIN RES, 148(1), 251 - 259.

    1975

    • MIRSKY R, THOMPSON EJ (1975). THY 1 (THETA) ANTIGEN ON SURFACE OF MORPHOLOGICALLY DISTINCT BRAIN CELL-TYPES. CELL, 4(2), 95 - 101.

    • Mirsky R, Jessen KR (). Development of Schwann cells. In (Ed.), The New Encyclopedia of Neuroscience (pp. - ). : Elsevier.