Dr Yoshiyuki Yamamoto


Personal Profile

Name: Yoshiyuki Yamamoto Email: yoshiyuki.yamamoto@ucl.ac.uk
Title: Dr Tel:
Department: Cell & Developmental Biology Fax:
Position: Lecturer Address: Anatomy Building, UCL, Gower Street, London, WC1E 6BT
Research Domain: Basic Life Sciences, Neuroscience Web Page: Personal Web Page


Research Description

My research goal is to understand the molecular mechanisms underlying the generation of morphological novelties during evolution. I am currently using the Mexican characin Astyanax Mexicanus as a model system for studying micro- and macroevolution and development.

Research Activities

Circadian rhythms. Light detection. Cell cycle timing.

Developmental Mechanisms of Evolutionary Morphology

Education Description

UCL Collaborators

Prof David Whitmore; Prof David Becker; Dr Manlio Vinciguerra

External Collaborators



    • Yoshizawa M, Yamamoto Y, O'Quin KE, Jeffery WR (2012). Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish. BMC BIOLOGY, 10, - . doi:10.1186/1741-7007-10-108


    • Yamamoto Y, Byerly MS, Jackman WR, Jeffery WR (2009). Pleiotropic functions of embryonic sonic hedgehog expression link jaw and taste bud amplification with eye loss during cavefish evolution. DEV BIOL, 330(1), 200 - 211. doi:10.1016/j.ydbio.2009.03.003


    • Strickler AG, Yamamoto Y, Jeffery WR (2007). The lens controls cell survival in the retina: Evidence from the blind cavefish Astyanax. DEV BIOL, 311(2), 512 - 523. doi:10.1016/j.ydbio.2007.08.050


    • Yamamoto Y, Jeffery W (2006). Why cavefish lost their eyes? Natural selection or neutral theory". INTEGR COMP BIOL, 46, E158 - E158.


    • Vihtelic TS, Yamamoto Y, Springer S, Jeffery WR, Hyde DR (2005). Lens opacity and photoreceptor degeneration in the zebrafish lens opaque mutant. Developmental Dynamics, 233(1), 52 - 65.
    • Trapani J, Yamamoto Y, Stock DW (2005). Ontogenetic transition from unicuspid to multicuspid oral dentition in a teleost fish: Astyanax mexicanus, the Mexican tetra (Ostariophysi : Characidae). ZOOL J LINN SOC-LOND, 145(4), 523 - 538.
    • Evans TG, Yamamoto Y, Jeffery WR, Krone PH (2005). Zebrafish Hsp70 is required for embryonic lens formation. Cell Stress and Chaperones, 10(1), 66 - 78. doi:10.1379/CSC-79R.1
    • Espinasa L, Yamamoto Y, Jeffery WR (2005). Non-optical releasers for aggressive behavior in blind and blinded Astyanax (Teleostei, Characidae).. Behavioural Processes, 70(2), 144 - 148.


    • Hooven T, Yamamoto Y, Jeffery WR (2004). Blind cavefish and heat shock protein chaperones: a novel role for hsp90alpha in lens apoptosis. International Journal of Developmental Biology, 48(8-9), 731 - 738. doi:10.1387/ijdb.041874th
    • Soares D, Yamamoto Y, Strickler AG, Jeffery WR (2004). The lens has a specific influence on optic nerve and tectum development in the blind cavefish Astyanax.. Developmental Neuroscience, 26(5-6), 308 - 317.
    • Yamamoto Y (2004). Cavefish. Current Biology, 14(22), R943 - . doi:10.1016/j.cub.2004.10.035
    • Yamamoto Y, Stock DW, Jeffery WR (2004). Hedgehog signalling controls eye degeneration in blind cavefish. Nature, 431(7010), 844 - 847. doi:10.1038/nature02864
    • Jeffery WR, Strickler AG, Yamamoto Y (2004). Migratory neural crest-like cells form body pigmentation in a urochordate embryo. Nature, 431(7009), 696 - 699. doi:10.1038/nature02975


    • Yamamoto Y, Espinasa L, Stock DW, Jeffery WR (2003). Development and evolution of craniofacial patterning is mediated by eye-dependent and -independent processes in the cavefish Astyanax.. Evolution and Development, 5(5), 435 - 446. doi:10.1046/j.1525-142X.2003.03050.x