Dr Masazumi Tada


Personal Profile

Name: Masazumi Tada Email: m.tada@ucl.ac.uk
Title: Dr Tel: 020 7679 6531
Department: Cell & Developmental Biology Fax:
Position: Reader in Developmental and Cellular Biology Address: Department of Cell & Developmental Biology, UCL, Gower Street, London, WC1E 6BT
Research Domain: Neuroscience Web Page: Personal Web Page


Research Description

I am interested in cellular and molecular mechanisms underlying co-ordinated and directional cell movements. The primary focus is on morphogenetic movements occurring during gastrualtion using the zebrafish as a model system; epiboly, convergence/extension and anterior migration of mesodermal cells. Since we showed that Wnt11 is an important regulator of convergence/extension movements during gastrulation in vertebrates, it has been evident that this ligand acts in a pathway related to the planar cell polarity (PCP) pathway in Drosophila. Recently, the core PCP genes have been also implicated in regulating a variety of morphogenetic processes in vertebrates including neural tube closure, orientation of cochlear hair cells, migration of facial motorneurons and ciliogenesis. Current projects are a) Understanding mechanisms by which core PCP proteins regulate gastrulation movements in zebrafish; b) Identifying and characterising genetic pathways that act in or in parallel with the PCP pathway during gastrulation; c) Exploring other biological processes that are regulated by the PCP genes and their genetic modifiers.

Research Activities

Mechanisms underlying morphogenetic movements

Signalling Pathways from Cell-Cell Adhesions

Signalling by the RAS family of oncogenes

Education Description

UCL Collaborators

Dr Pablo Rodriguez-Viciana; Prof David Becker; Dr Stephen Price; Prof Philip Beales; Prof Steve Wilson; Dr Alexander Hergovich

External Collaborators



    • Kajita M, Sugimura K, Ohoka A, Burden J, Suganuma H, Ikegawa M, Shimada T, Kitamura T, Shindoh M, Ishikawa S, Yamamoto S, Saitoh S, Yako Y, Takahashi R, Okajima T, Kikuta J, Maijima Y, Ishii M, Tada M, Fujita Y (2014). Filamin acts as a key regulator in epithelial defence against transformed cells.. Nat Commun, 5, 4428 - . doi:10.1038/ncomms5428
    • Hori A, Ikebe C, Tada M, Toda T (2014). Msd1/SSX2IP-dependent microtubule anchorage ensures spindle orientation and primary cilia formation. EMBO REPORTS, 15(2), 175 - 184. doi:10.1002/embr.201337929
    • Lours-Calet C, Alvares LE, El-Hanfy AS, Gandesha S, Walters EH, Sobreira DR, Wotton KR, Jorge EC, Lawson JA, Kelsey Lewis A, Tada M, Sharpe C, Kardon G, Dietrich S (2014). Evolutionarily conserved morphogenetic movements at the vertebrate head-trunk interface coordinate the transport and assembly of hypopharyngeal structures.. Dev Biol, 390(2), 231 - 246. doi:10.1016/j.ydbio.2014.03.003
    • Lepage SE, Tada M, Bruce AEE (2014). Zebrafish Dynamin is required for maintenance of enveloping layer integrity and the progression of epiboly. DEVELOPMENTAL BIOLOGY, 385(1), 52 - 66. doi:10.1016/j.ydbio.2013.10.015


    • Norman M, Wisniewska KA, Lawrenson K, Garcia-Miranda P, Tada M, Kajita M, Mano H, Ishikawa S, Ikegawa M, Shimada T, Fujita Y (2012). Loss of Scribble causes cell competition in mammalian cells.. J Cell Sci, 125(Pt 1), 59 - 66. doi:10.1242/jcs.085803
    • Tada M, Heisenberg CP (2012). Convergent extension: using collective cell migration and cell intercalation to shape embryos.. Development, 139(21), 3897 - 3904. doi:10.1242/dev.073007
    • Lee O, Takesono A, Tada M, Tyler CR, Kudoh T (2012). Biosensor Zebrafish Provide New Insights into Potential Health Effects of Environmental Estrogens. ENVIRONMENTAL HEALTH PERSPECTIVES, 120(7), 990 - 996. doi:10.1289/ehp.1104433
    • Tada M, Kai M (2012). Planar cell polarity in coordinated and directed movements.. Curr Top Dev Biol, 101, 77 - 110. doi:10.1016/B978-0-12-394592-1.00004-1


    • Carmona-Fontaine C, Theveneau E, Tzekou A, Tada M, Woods M, Page KM, Parsons M, Lambris JD, Mayor R (2011). Complement fragment C3a controls mutual cell attraction during collective cell migration.. Dev Cell, 21(6), 1026 - 1037. doi:10.1016/j.devcel.2011.10.012
    • Mapp OM, Walsh GS, Moens CB, Tada M, Prince VE (2011). Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity. DEVELOPMENT, 138(10), 2121 - 2132. doi:10.1242/dev.060442
    • Trichas G, Joyce B, Crompton LA, Wilkins V, Clements M, Tada M, Rodriguez TA, Srinivas S (2011). Nodal Dependent Differential Localisation of Dishevelled-2 Demarcates Regions of Differing Cell Behaviour in the Visceral Endoderm. PLOS BIOL, 9(2), - . doi:10.1371/journal.pbio.1001019
    • Clark MD, Guryev V, de Bruijn E, Nijman IJ, Tada M, Wilson C, Deloukas P, Postlethwait JH, Cuppen E, Stemple DL (2011). Single Nucleotide Polymorphism (SNP) Panels for Rapid Positional Cloning in Zebrafish. METHOD CELL BIOL, 104, 221 - 235. doi:10.1016/B978-0-12-374814-0.00013-6


    • Kajita M, Hogan C, Harris AR, Dupre-Crochet S, Itasaki N, Kawakami K, Charras G, Tada M, Fujita Y (2010). Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells. J CELL SCI, 123(2), 171 - 180. doi:10.1242/jcs.057976
    • Oteiza P, Koppen M, Krieg M, Pulgar E, Farias C, Melo C, Preibisch S, Muller D, Tada M, Hartel S, Heisenberg CP, Concha ML (2010). Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ. DEVELOPMENT, 137(20), 3459 - 3468. doi:10.1242/dev.049981
    • May-Simera HL, Kai M, Hernandez V, Osborn DP, Tada M, Beales PL (2010). Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish.. Dev Biol, 345(2), 215 - 225. doi:10.1016/j.ydbio.2010.07.013


    • Tada M, Kai M (2009). Noncanonical Wnt/PCP Signaling During Vertebrate Gastrulation. Zebrafish, 6(1), 29 - 40. doi:10.1089/zeb.2008.0566
    • Carreira-Barbosa F, Kajita M, Morel V, Wada H, Okamoto H, Martinez Arias A, Fujita Y, Wilson SW, Tada M (2009). Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation. Development, 136, 383 - 392. doi:10.1242/dev.026542


    • Tobin JL, Di Franco M, Eichers E, May-Simera H, Garcia M, Yan J, Quinlan R, Justice MJ, Hennekam RC, Briscoe J, Tada M, Mayor R, Burns AJ, Lupski JR, Hammond P, Beales PL (2008). Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome.. Proc Natl Acad Sci U S A, 105(18), 6714 - 6719. doi:10.1073/pnas.0707057105
    • Kai M, Heisenberg C-P, Tada M (2008). Sphingosine-1-phosphate receptors regulate individual cell behaviours underlying the directed migration of prechordal plate progenitor cells during zebrafish gastrulation. Development, 135(18), 3043 - 3051. doi:10.1242/dev.020396


    • Tawk M, Araya C, Lyons DA, Reugels AM, Girdler GC, Bayley PR, Hyde DR, Tada M, Clarke JDW (2007). A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature, 446, 797 - 800. doi:10.1038/nature05722
    • Caneparo L, Huang YL, Staudt N, Tada M, Ahrendt R, Kazanskaya O, Niehrs C, Houart C (2007). Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/βcatenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek. Genes and Development, 21(4), 465 - 480.
    • Beales PL, Bland E, Tobin JL, Bacchelli C, Tuysuz B, Hill J, Rix S, Pearson CG, Kai M, Hartley J, Johnson C, Irving M, Elcioglu N, Winey M, Tada M, Scambler PJ (2007). IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy. Nature Genetics, 39(6), 727 - 729. doi:10.1038/ng2038
    • Blanco MJ, Barrallo-Gimeno A, Acloque H, Reyes AE, Tada M, Allende ML, Mayor R, Nieto MA (2007). Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo. Development, 134(22), 4073 - 4081. doi:10.1242/10.1242/dev.006858


    • Ross A, May-Simera H, Eichers E, Kai M, Hill J, Jagger D, Leitch C, Chapple JP, Munro P, Fisher S, Tan P, Phillips H, Leroux M, Henderson D, Murdoch J, Copp A, Eliot MM, Lupski J, Kemp D, Dollfus H, Tada M, Katsanis N, Forge A, Beales P (2006). Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates.
    • Witzel S, Zimyanin V, Carreira-Barbosa F, Tada M, Heisenberg C-P (2006). Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane. The Journal of Cell Biology, 175, 791 - 802. doi:10.1083/jcb.200606017


    • Tada M (2005). Notochord morphogenesis: a prickly subject for ascidians. Current Biology, 15(1), R14 - 16.
    • Ross AJ, May-Simera H, Eichers ER, Kai M, Hill J, Jagger DJ, Leitch CC, Chapple JP, Munro PM, Fisher S, Tan PL, Phillips HM, Leroux MR, Henderson DJ, Murdoch JN, Copp AJ, Eliot MM, Lupski JR, Kemp DT, Dollfus H, Tada M, Katsanis N, Forge A, Beales PL (2005). Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nature Genetics, 37(10), 1135 - 1140. doi:10.1038/ng1644
    • Cavodeassi F, Carreira-Barbosa F, Young RM, Concha ML, Allende ML, Houart C, Tada M, Wilson SW (2005). Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/β-catenin pathway. Neuron, 47(1), 43 - 56. doi:10.1016/j.neuron.2005.05.026


    • Ohkawara B, Yamamoto TS, Tada M, Ueno N (2003). Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis.. Development, 130, 2129 - 2138.
    • Trindade M, Messenger N, Papin C, Grimmer D, Fairclough L, Tada M, Smith JC (2003). Regulation of apoptosis in the Xenopus embryo by Bix3. Development, 130, 4611 - 4622.
    • Carreira-Barbosa F, Concha ML, Takeuchi M, Ueno N, Wilson SW, Tada M (2003). Prickle1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Development, 130, 4037 - 4046. doi:10.1242/dev.00567
    • Kilian B, Mansukoski H, Carreira-Barbosa F, Ulrich F, Tada M, Heisenberg C-P (2003). The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mechanisms of Development, 120, 467 - 476.
    • Ulrich F, Concha ML, Heid PJ, Voss E, Witzel S, Roehl H, Tada M, Wilson SW, Adams RJ, Soll DR, Heisenberg CP (2003). Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation. Development, 130, 5375 - 5384. doi:10.1242/dev.00758


    • Tada M, Concha ML, Heisenberg C-P (2002). Non-canonical Wnt signalling and regulation of gastrulation movements. Seminars in Cell and Developmental Biology, 13, 251 - 260.
    • Heisenberg C-P, Tada M (2002). Zebrafish gastrulation movements: Bridging cell and developmental biology. Seminars in Cell and Developmental Biology, 137(471), 479 - .
    • Heisenberg C-P, Tada M (2002). Wnt signalling: A moving picture emerges from van gogh. Current Biology, 12, R126 - R128.
    • Heisenberg CP, Tada M (2002). Zebrafish gastrulation movements: bridging cell and developmental biology. SEMIN CELL DEV BIOL, 13(6), 471 - 479. doi:10.1016/S1084-9521(02)00100-3


    • Tada M, Smith JC (2001). T-targets: clues to understanding the functions of T-box proteins.. Dev Growth Differ, 43(1), 1 - 11.
    • Tada M, Concha ML (2001). Vertebrate gastrulation: Calcium waves orchestrate cell movements. Current Biology, 11, R470 - R472.


    • Heisenberg CP, Tada M, Rauch GJ, Saúde L, Concha ML, Geisler R, Stemple DL, Smith JC, Wilson SW (2000). Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation.. Nature, 405(6782), 76 - 81. doi:10.1038/35011068
    • Tada M, Smith JC (2000). Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway.. Development, 127(10), 2227 - 2238.