Dr Alan Burns

Photo

Personal Profile

Name: Alan Burns Email: alan.burns@ucl.ac.uk
Title: Dr Tel: 020 7905 2721
Department: ICH - Neural Development Unit Fax: 020 7831 4366
Position: Senior Lecturer Address: 30 Guildford Street, London, London, WC1N 1EH
Research Domain: Basic Life Sciences, Neuroscience, Personalised Medicine, Populations & Lifelong Health, Stem Cells & Regenerative Medicine (Frontier Disciplines) Web Page: Personal Web Page

Profile

Research Description

The overall aim of my work is to better understand, and establish novel treatments for, disorders/diseases resulting from abnormal development of the neuromuscular components of the gastrointestinal tract. Normal gut contraction and function requires the coordinated interaction of enteric neurons and glia, interstitial cells of Cajal, and smooth muscle cells. Defects in the development of these cell types results in a range of commonly occurring gut disorders/diseases including Hirschsprung disease (aganglionic hindgut), intestinal pseudo-obstruction, and other motility defects. We take a number of approaches, in collaboration with groups locally, nationally and internationally to:

(i) investigate the mechanisms controlling enteric nervous system (ENS) formation from neural crest-derived precursors

(ii) determine, by functional analysis, whether candidate genes identified in enteric neuropathies and myopathies, are actually disease causing genes

(iii) develop novel stem cell-based therapies for aganglionic gut disorders such as Hirschsprung disease

(iv) use tissue engineering approaches to manufacture replacements for diseased gut.


Research Activities

Biology and therapeutic potential of enteric nervous system stem cells for spinal cord repair

Normal and abnormal development of the neuromuscular components of the gut

Novel therapies for gut disorders/diseases

Education Description

I am co-director of the MRes in Biomedicine course which is based at UCL Institute of Child Health. This is a comprehensive, one year laboratory research orientated course designed to train and equip students prior to entering PhD or higher degree training.  Tasks involve organizing and helping to deliver a three month taught module. This is followed by placing and assessing students in a three month mini project and six month maxi project in areas such as birth defects research, stem cell research, infection and immunity, childhood development and metabolic defects and cancer. I also teach at post-graduate level on the  MSc in Molecular Medicine (UCL Institute of Child Health),  MSc in Prenatal Genetics and Fetal Medicine (UCL), MSc in Paediatric Gastroenterology (Barts and the London School of Medicine and Dentistry), and at undergraduate level for the BSc Cellular and Developmental Neurobiology (UCL).

UCL Collaborators

Dr Suwan Jayasinghe; Dr Vassilis Pachnis; Dr Richard Day; Prof Philip Beales; Dr Simon Eaton; Dr Paolo De Coppi; Prof Christiana Ruhrberg; Dr Steven Howe; Dr Nikhil Thapar

External Collaborators

Professor Robert Hofstra; Dr Allan Goldstein; Professor Wood Yee Chan

Publications

    2014

    • Burns AJ, Thapar N (2014). Neural stem cell therapies for enteric nervous system disorders. Nature Reviews Gastroenterology and Hepatology, 11, 317 - 328. doi:10.1038/nrgastro.2013.226
    • Delalande JM, Vernay B, Natarajan D, Finlay M, Ruhrberg C, Thapar N, Burns AJ (2014). Vascularisation is not necessary for gut colonisation by enteric neural crest cells. Developmental Biology, 385(2), 220 - 229. doi:10.1016/j.ydbio.2013.11.007

    2013

    • Fishman JM, Lowdell MW, Urbani L, Ansari T, Burns AJ, Turmaine M, North J, Sibbons P, Seifalian AM, Wood KJ, Birchall MJ, De Coppi P (2013). Immunomodulatory effect of a decellularized skeletal muscle scaffold in a discordant xenotransplantation model. Proc Natl Acad Sci USA, 110(35), 14360 - 14365. doi:10.1073/pnas.1213228110
    • Orlando G, Booth C, Wang Z, Totonelli G, Ross CL, Moran E, Salvatori M, Maghsoudlou P, Turmaine M, Delario G, Al-Shraideh Y, Farooq U, Farney AC, Rogers J, Iskandar SS, Burns A, Marini FC, De Coppi P, Stratta RJ, Soker S (2013). Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies. Biomaterials, 34(24), 5915 - 5925. doi:10.1016/j.biomaterials.2013.04.033
    • Goldstein AM, Hofstra RWM, Burns AJ (2013). Building a brain in the gut:development of the enteric nervous system. Clinical Genetics, 83(4), 307 - 316. doi:10.1111/cge.12054
    • Shamir R, James-Roberts IS, Di Lorenzo C, Burns AJ, Thapar N, Indrio F, Riezzo G, Raimondi F, Di Mauro A, Francavilla R, Leuchter RH, Darque A, Hüppi PS, Heine RG, Bellaïche M, Levy M, Jung C, Alvarez M, Hovish K (2013). Infant crying, colic, and gastrointestinal discomfort in early childhood: a review of the evidence and most plausible mechanisms.. J Pediatr Gastroenterol Nutr, 57 Suppl 1, S1 - . doi:10.1097/MPG.0b013e3182a154ff
    • Heanue T, Burns AJ (2013). Development of the enteric neuromuscular system. In Faure C, DiLorenzo C, Thapar N (Ed.), Pediatric Neurogastroenterology: Gastrointestinal Motility and Functional Disorders in Children (pp. 9 - 21). : Humana Press. doi:10.1007/978-1-60761-709-9_2
    • Hotta R, Natarajan D, Burns AJ, Thapar N (2013). Cellular-Based Therapies for Pediatric GI Motility Disorders. In Faure C, Di Lorenzo C, Thapar N (Ed.), Pediatric Neurogastroenterology: Gastrointestinal Motility and Functional Disorders in Children (pp. 493 - 505). : Humana Press. doi:10.1007/978-1-60761-709-9_45
    • Carnaghan H, Roberts T, Savery D, Norris F, McCann CJ, Copp AJ, Scambler P, Lythgoe M, Greene NDE, DeCoppi P, Burns A, Pierro A, Eaton S (2013). Novel exomphalos genetic mouse model: the importance of accurate phenotypic characterisation.. Journal of Pediatric Surgery, 48(10), 2036 - 2042. doi:10.1016/j.jpedsurg.2013.04.010.
    • Burns AJ, Thapar N (2013). Developmental and postnatal changes in the enteric nervous system. Journal of Pediatric Gastroenterology and Nutrition, , - . doi:10.1097/01.mpg.0000441925.75189.01
    • Maghsoudlou P, Georgiades F, Tyraskis A, Totonelli G, Loukogeorgakis SP, Orlando G, Shangaris P, Lange P, Delalande JM, Burns AJ, Cenedese A, Sebire NJ, Turmaine M, Guest BN, Alcorn JF, Atala A, Birchall MA, Elliott MJ, Eaton S, Pierro A, Gilbert TW, De Coppi P (2013). Preservation of micro-architecture and angiogenic potential in a pulmonary acellular matrix obtained using intermittent intra-tracheal flow of detergent enzymatic treatment.. Biomaterials, 34(28), 6638 - 6648. doi:10.1016/j.biomaterials.2013.05.015

    2012

    • Totonelli G, Maghsoudlou P, Garriboli M, Riegler J, Orlando G, Burns AJ, Sebire NJ, Smith VV, Fishman JM, Ghionzoli M (2012). A rat decellularized small bowel scaffold that preserves villus-crypt architecture for intestinal regeneration. Biomaterials, 33(12), 3401 - 3410. doi:10.1016/j.biomaterials.2012.01.012
    • Thapar N, Burns AJ (2012). Use of enteric nervous system stem cells to treat motility disorders: ready for prime time?. doi:10.1111/j.1365-2982.2012.01995.x
    • Nagy N, Burns AJ, Goldstein AM (2012). Immunophenotypic characterization of enteric neural crest cells in the developing avian colorectum. Developmental Dynamics, 241(5), 842 - 851. doi:10.1002/dvdy.23767
    • Freem LJ, Delalande JM, Campbell AM, Thapar N, Burns AJ (2012). Lack of organ specific commitment of vagal neural crest cell derivatives as shown by back-transplantation of GFP chicken tissues. The International Journal of Developmental Biology, 56, 245 - 254. doi:10.1387/ijdb.113438lf
    • Totonelli G, Maghsoudlou P, Garriboli M, Georgiades F, Delalande JM, Thapar N, Pierro A, Eaton S, Burns AJ, De Coppi P (2012). Recellularization of a natural intestinal matrix using chicken chorioallantoic membrane as an in vivo bioreactor.
    • Panza E, Knowles CH, Graziano C, Thapar N, Burns AJ, Seri M, Stanghellini V, De Giorgio R (2012). Genetics of human enteric neuropathies.. Prog Neurobiol, 96(2), 176 - 189. doi:10.1016/j.pneurobio.2012.01.001
    • Sasselli V, Pachnis V, Burns AJ (2012). The enteric nervous system. DEVELOPMENTAL BIOLOGY, 366(1), 64 - 73. doi:10.1016/j.ydbio.2012.01.012
    • Fotis L, Burns AJ, Thapar N (2012). Gastrointestinal Tract: Congenital Abnormalities. In (Ed.), Encyclopedia of Life Sciences (eLS) (pp. - ). : John Wiley & Sons Ltd.. doi:10.1002/9780470015902.a0002138.pub2
    • Burns AJ (2012). Ongoing development of the enteric nervous system. doi:10.1111/j.1365-2982.2012.01995.x

    2011

    • Calmont A, Thapar N, Scambler PJ, Burns AJ (2011). Absence of the vagus nerve in the stomach of Tbx1-/- mutant mice. Neurogastroenterology And Motility, 23(2), 125 - 130. doi:10.1111/j.1365-2982.2010.01615.x
    • Hotta R, Natarajan D, Burns AJ, Thapar N (2011). Stem cells for GI motility disorders.. Curr Opin Pharmacol, 11(6), 617 - 623. doi:10.1016/j.coph.2011.09.004
    • Sribudiani Y, Metzger M, Osinga J, Rey A, Burns AJ, Thapar N, Hofstra RM (2011). Variants in RET associated with Hirschsprung disease affect binding of transcription factors and gene expression. Gastroenterology, 140(2), 572 - 582. doi:10.1053/j.gastro.2010.10.044
    • Wang X, Chan AK, Sham MH, Burns AJ, Chan WY (2011). Analysis of the sacral neural crest cell contribution to the hindgut enteric nervous system in the mouse embryo. Gastroenterology, 141(3), 992 - 1002. doi:10.1053/j.gastro.2011.06.002
    • Chen J-L, Wang X, Enomoto H, Sham M-H, Burns AJ, Chan WY (2011). Dynamic migratory behaviors of neural crest cells in the mouse hindgut.
    • Freem, LJ , Tannahill, D , Thapar, N , Burns, AJ (2011). Colonisation of the developing mouse lung by neural crest cells as demonstrated by Optical Projection Tomography.
    • Rooryck C, Diaz-Font A, Osborn DP, Chabchoub E, Hernandez-Hernandez V, Shamseldin H, Kenny J, Waters A, Jenkins D, Kaissi AA, Leal GF, Dallapiccola B, Carnevale F, Bitner-Glindzicz M, Lees M, Hennekam R, Stanier P, Burns AJ, Peeters H, Alkuraya FS, Beales PL (2011). Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome. Nat.Genet., 43, 197 - 203. doi:10.1038/ng.757

    2010

    • Keshaw H, Thapar N, Burns AJ, Knowles J, Forbes A, Day RM (2010). Microporous collagen spheres produced via thermally induced phase separation for tissue regeneration. Acta Biomaterialia, 6(3), 1158 - 1166. doi:10.1016/j.actbio.2009.08.044
    • Binder E, Cananzi M, Burns AJ, Thapar N (2010). ENTERIC NERVOUS SYSTEM STEM CELL-CONTAINING NEUROSPHERES: ALL THAT GLITTERS IS NOT GOLD?. doi:10.1136/gut.2009.209049g
    • Calmont A, Thapar N, Scambler PJ, Burns AJ (2010). Absence of the vagus nerve in the stomach of Tbx1 mutant mice. doi:10.1111/j.1365-2982.2010.01549.x
    • Baiguera S, Jungebluth P, Burns A, Mavilia C, Haag J, De Coppi P, Macchiarini P (2010). Tissue engineered human tracheas for in vivo implantation. Biomaterials, 31(34), 8931 - 8938. doi:10.1016/j.biomaterials.2010.08.005
    • Ahmadi R, Burns AJ, de Bruijn JD (2010). Chitosan-based hydrogels do not induce angiogenesis.. J Tissue Eng Regen Med, 4(4), 309 - 315. doi:10.1002/term.247
    • Freem LJ, Escot S, Tannahill D, Druckenbrod NR, Thapar N, Burns AJ (2010). The intrinsic innervation of the lung is derived from neural crest cells as shown by optical projection tomography in Wnt1-Cre;YFP reporter mice.. J Anat, 217(6), 651 - 664. doi:10.1111/j.1469-7580.2010.01295.x

    2009

    • Alexander N, Eaton S, Haston M, Wallace AS, Smith VV, Burns AJ, Salomon J, Shah N, Klein NJ, Pierro A, Thapar N (2009). Hirschsprung's disease associated enterocolitis is related to defects in innate immunity.
    • Burns AJ, Bradshaw L, Freem LJ, Davey MG, Thapar N (2009). Analysis of talpid3 mutant chicken embryos reveals defects in gut and enteric nervous system development.
    • Freem LJ, Thapar N, Burns AJ (2009). Investigation of the embryological origin and development of intrinsic nerve ganglia within the mouse and human lung.
    • Freem LJ, Escot S, Thapar N, Burns AJ (2009). Colonisation of the developing lungs by tangential migration of foregut-derived vagal neural crest cells.
    • Wang X, Bao LH, Li M, Burns AJ, Chan WY (2009). Migration of mouse sacral neural crest cells from their origin to the hindgut.
    • Burns AJ, Pachnis V (2009). Development of the enteric nervous system: bringing together cells, signals and genes. Neurogastroenterology and Motility, 21, 100 - 102. doi:10.1111/j.1365-2982.2008.01255.x
    • Burns AJ, Roberts RR, Bornstein JC, Young HM (2009). Development of the enteric nervous system and its role in intestinal motility during fetal and early post-natal stages. Seminars in Pediatric Surgery, 18(4), 196 - 205. doi:10.1053/j.sempedsurg.2009.07.001
    • Metzger M, Caldwell C, Barlow AJ, Burns AJ, Thapar N (2009). Therapeutic potential of human enteric nervous system stem cells derived from endoscopic gut mucosal biopsies.
    • Wallace AS, Barlow AJ, Navaratne L, Delalande JM, Tauszig-Delamasure S, Corset V, Thapar N, Burns AJ (2009). Inhibition of cell death results in hyperganglionosis: implications for enteric nervous system development. Neurogastroenterology and Motility, 21(7), 768 - e49. doi:10.1111/j.1365-2982.2009.01309.x
    • Freem L, J T, N B, A J (2009). Development of intrinsic lung neurons from foregut-derived neural crest cells. doi:10.1016/j.mod.2009.06.878
    • Burns AJ, Bradshaw L, Davey MG, Thapar N (2009). Defects in gut and enteric nervous system development in Talpid3 mutant chicken. doi:10.1016/j.mod.2009.06.566
    • Wang X, Burns AJ, Chan WY (2009). Pre-enteric migration of sacral neural crest cells is affected in Dominant megacolon embryos. doi:10.1016/j.mod.2009.06.835
    • Metzger M, Caldwell C, Barlow AJ, Burns AJ, Thapar N (2009). Enteric nervous system stem cells derived from human gut mucosa for the treatment of aganglionic gut disorders.. Gastroenterology, 136(7), 2214 - 2225. doi:10.1053/j.gastro.2009.02.048
    • Metzger M, Wallace AS, Schaefer KH, Burns AJ, Thapar N (2009). Development of the mucosal plexus of the human enteric nervous system.
    • Schaefer KH, Maas-Omlor S, Burns AJ, Rauch U (2009). Correlated expression of S100 and GFAP in enteric glia in rodent and human gut.
    • Burns AJ (2009). Enteric nervous system developmental potential of vagal and sacral neural crest cells.

    2008

    • Burns AJ, Thapar N, Barlow AJ (2008). Development of the Neural Crest-derived Intrinsic Innervation of the Human Lung. American Journal of Respiratory Cell and Molecular Biology, 38(3), 269 - 275. doi:10.1165/rcmb.2007-0246OC
    • O'Keeffe MB, Devlin AH, Burns AJ, Gardiner TA, Logan ID, Hirst DG, McKeown SR (2008). Investigation of pericytes, hypoxia, and vascularity in bladder tumors: association with clinical outcomes. Oncology Research, 17(3), 93 - 101.
    • Dong M, Wang X, Chan AK, Burns AJ, Chan WY (2008). Early migration of sacral neural crest cells in mouse embryos. Neuroembryology and Aging, 4(4), 189 - 201. doi:10.1159/000118929
    • Tobin JL, Di Franco M, Eichers E, May-Simera H, Garcia M, Yan J, Quinlan R, Justice MJ, Hennekam RC, Briscoe J, Tada M, Mayor R, Burns AJ, Lupski JR, Hammond P, Beales PL (2008). Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome.. Proc Natl Acad Sci U S A, 105(18), 6714 - 6719. doi:10.1073/pnas.0707057105
    • Barlow AJ, Wallace AS, Thapar N, Burns AJ (2008). Critical numbers of neural crest cells are required in the pathways from the neural tube to the foregut to ensure complete enteric nervous system formation. Development, 135(9), 1681 - 1691. doi:10.1242/dev.017418
    • Delalande JM, Barlow AJ, Thomas AJ, Wallace AS, Thapar N, Erickson CA, Burns AJ (2008). The receptor tyrosine kinase RET regulates hindgut colonization by sacral neural crest cells.. Developmental Biology, 313(1), 279 - 292. doi:10.1016/j.ydbio.2007.10.028

    2007

    • Burns AJ (2007). Colonisation of the gut by neural crest-derived enteric nervous system precursors: migration pathways and developmental potentials.
    • Andoniadou CL, Signore M, Sajedi E, Gaston-Massuet C, Kelberman D, Burns AJ, Itasaki N, Dattani M, Martinez-Barbera JP (2007). Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development, 134(8), 1499 - 1508. doi:10.1242/dev.02829
    • Cananzi M, Metzger M, Malerba A, Burns AJ, Pierro A, Thapar N, de Coppi P (2007). Amniotic fluid stem cells participate in intestinal organogenesis in a model of gut development on chick chorioallantoic membrane..
    • Metzger M, Just L, Caldwell C, Burns AJ, Thapar N (2007). Isolation and biological potential of enteric nervous system precursors derived from human gut.
    • Caldwell, C , Burns AJ, Thapar, N (2007). Isolation, characterisation and transplantation of human enteric nervous system stem cells.
    • Burns AJ (2007). Disorders of interstitial cells of Cajal.. J Pediatr Gastroenterol Nutr, 45 Suppl 2, S103 - S106. doi:10.1097/MPG.0b013e31812e65e0
    • Caldwell C, Burns AJ, Barlow A, Thapar N (2007). Isolation and transplantation of human enteric nervous system stem cells.

    2006

    • Burns AJ, Thapar N (2006). Advances in ontogeny of the enteric nervous system. Neurogastroenterol Motil, 18(10), 876 - 887. doi:10.1111/j.1365-2982.2006.00806.x
    • Thapar N, Natarajan D, Caldwell C, Burns AJ, Pachnis V (2006). Isolation of enteric nervous system progenitors from Hirschsprung’s-like gut.
    • Young HM, Newgreen DF, Burns AJ (2006). Development of the enteric nervous system in relation to Hirschsprung’s Disease. In Ferretti P, Copp A, Tickle C, Moore G (Ed.), Embryos, Genes and Birth Defects, 2nd Edition (pp. 263 - 300). : John Wiley and Sons Ltd.
    • Dong M, Yip FP, Burns AJ, Chan WY (2006). Early migration of the mouse sacral neural crest.
    • Chan AK, Burns AJ, Chan WY (2006). The early migratory pathways of mouse sacral neural crest cells. doi:10.1016/j.ijdevneu.2006.09.096

    2005

    • Burns AJ, Wallace AS, Delalande JM, Tauszig-Delamasure S, Mehlen P (2005). Analysis of the role of RET as a dependence receptor during development of the enteric nervous system in the chick embryo.
    • Burns AJ (2005). Migration of neural crest-derived enteric nervous system precursor cells to and within the gastrointestinal tract. International Journal of Developmental Biology, 49(2-3), 143 - 150.
    • Burns AJ, Wallace AS, Delalande JM, Tauszig-Delamasure S, Mehlen P (2005). Analysis of the role of RET as a dependence receptor during development of the enteric nervous system in the chick embryo. MECH DEVELOP, 122, S118 - S118.
    • Burns AJ, Delalande JM (2005). Neural crest cell origin for intrinsic ganglia of the developing chicken lung. Developmental Biology, 277(1), 63 - 79. doi:10.1016/j.ydbio.2004.09.006
    • Wallace AS, Burns AJ (2005). Development of the enteric nervous system, smooth muscle and interstitial cells of Cajal in the human gastrointestinal tract. Cell and Tissue Research, 319(3), 367 - 382. doi:10.1007/s00441-004-1023-2

    2004

    • Burns AJ, Pasricha PJ, Young HM (2004). Enteric neural crest-derived cells and neural stem cells: biology and therapeutic potential. Neurogastroenterology and Motility, 16(1), 3 - 7. doi:10.1111/j.1365-2982.2003.00492.x
    • Delalande JM, Milla PJ, Burns AJ (2004). Hepatic nervous system development. ANAT REC A DISCOV MOL CELL EVOL BIOL, 280(1), 848 - 853. doi:10.1002/ar.a.20090

    2003

    • Delalande JM, Cooper J, Burns AJ (2003). Investigation of the signalling mechanisms involved in the development of sacral neural crest-derived enteric nervous system precursors.
    • Burns AJ, Wallace AS, Delalande JM (2003). Murine neural crest cells form the enteric nervous system in chick embryos following interspecies grafting.
    • Wallace AS, Burns AJ (2003). Spatiotemporal migration of neural crest cells within the human gastrointestinal tract.

    2002

    • Burns AJ, Delalande JM, Le Douarin NM (2002). In ovo transplantation of enteric nervous system precursors from vagal to sacral neural crest results in extensive hindgut colonisation. Development, 129, 2785 - 2796.

    2001

    • Burns AJ, Le Douarin NM (2001). Enteric nervous system development: analysis of the selective developmental potentialities of vagal and sacral neural crest cells using quail-chick chimeras. The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, 262(1), 16 - 28. doi:10.1002/1097-0185(20010101)262:1<16::AID-AR1007>3.0.CO;2-O

    2000

    • Burns AJ, Le Douarin NM (2000). Transplantation of enteric nervous system precursors from the vagal to the sacral neural crest region results in extensive hindgut colonisation..
    • Burns AJ, Champeval D, Le Douarin NM (2000). Sacral neural crest cells colonise aganglionic hindgut in vivo but fail to compensate for lack of enteric ganglia. Developmental Biology, 219(1), 30 - 43.

    1998

    • Burns AJ, Allen JM, McKerr G (1998). The spatial organisation of the central nervous system of Mesocestoides corti as revealed by microinjection of carbocyanine dye. International Journal for Parasitology, 28(2), 363 - 368.
    • Burns AJ, Le Douarin NM (1998). The sacral neural crest contributes neurons and glia to the post-umbilical gut: spatiotemporal analysis of the development of the enteric nervous system. Development, 125(21), 4335 - 4347.

    1997

    • Burns AJ, Le Douarin NM (1997). Colonisation of the avian hindgut by neural crest-derived cells occurs along two migration fronts.
    • Burns AJ, Herbert TM, Ward SM, Sanders KM (1997). Interstitial cells of Cajal in the guinea-pig gastrointestinal tract as revealed by c-Kit immunohistochemistry. Cell and Tissue Research, 290(1), 11 - 20.

    1996

    • Burns AJ, Lomax AEJ, Torihashi S, Sanders KM, Ward SM (1996). The role of interstitial cells of cajal in inhibitory neurotransmission within the gastric fundus.
    • Burns AJ, Lomax AEJ, Torihashi S, Sanders KM, Ward SM (1996). Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach. Proceedings of the National Academy of Sciences of the United States of America, 93(21), 12008 - 12013.
    • Ward SM, Bayguinov J, Stratton CJ, Burns AJ, Sanders KM (1996). Developmental changes in interstitial cells of Cajal in the murine oesophagus.

    1995

    • Shuttleworth CWR, Burns AJ, Ward SM, O'Brien WE, Sanders KM (1995). Recycling of L-citrulline to sustain nitric oxide-dependent enteric neurotransmission. Neuroscience, 68(4), 1295 - 1304.
    • Burns AJ, Torihashi S, Harney SC, Sanders KM, Ward SM (1995). Regulation of the development of interstitial cells of Cajal in the gastrointestinal tract.
    • Burns AJ, Howard CV, Allen JM, VanVelsen D, McKerr G (1995). Stereological estimation of gap junction surface area per neuron in the developing nervous system of the invertebrate Mesocestoides corti. Parasitology, 111(505), 513 - .
    • Harney SC, Burns AJ, Bayguinov YR, Sanders KM, Ward SM (1995). In vivo and in vitro development of electrical rhythmicity in the murine small intestine.
    • Ward SM, Burns AJ, Torihashi S, Harney SC, Sanders KM (1995). Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants. American Journal of Physiology - Cell Physiology, 269(6), C1577 - C1585.
    • Sanders KM, Torihashi S, Burns AJ, Ward SM (1995). Morphological, physiological, and genetic evidence for a role of interstitial cells as intestinal pacemakers. doi:10.1159/000317862
    • Burns AJ, Torihashi S, Harney SH, Sanders KM, Ward SM (1995). The effect of the c-kit mutation on the development of the interstitial cell network in the murine stomach and colon.
    • Torihashi S, Kobayshi S, Ward SM, Burns AJ, Sanders KM (1995). Development of the c-kit receptor presenting cells in the mouse small intestine and their pacemaker activity.

    1994

    • Ward SM, Torihashi S, Burns AJ, Sanders KM (1994). Loss of intestinal electrical rhythmicity when tyrosine kinase function of c-kit protein is impaired.
    • Ward SM, Burns AJ, Torihashi S, Sanders KM (1994). Mutation in the proto-oncogene c-kit blocks development of the interstitial cells and electrical rhythmicity in murine intestine. The Journal of Physiology, 480(1), 91 - 97.

    1993

    • Yaegashi H, Howard CV, McKerr G, Burns AJ (1993). Stereological estimation of the total number of neurons in the asexually dividing tetrathyridium of Mesocestoides Corti. Parasitology, 106(2), 177 - 183.

    • Burns AJ, Thapar N (). Neural stem cell therapies for enteric nervous system disorders. Nature Reviews Gastroenterology and Hepatology, , - .
    • Burns AJ, Thapar N (). Neural stem cell therapies for enteric nervous system disorders. Nature Reviews Gastroenterology and Hepatology, , - .