Prof John Greenwood

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Personal Profile

Name: John Greenwood Email: j.greenwood@ucl.ac.uk
Title: Prof Tel: 020 7608 6858
Department: Inst Ophthalmology - Cell Biology Fax: 020 76086810
Position: Davson Professor of Biomedical Research Address: Institute of Ophthalmology, UCL, 11-43 Bath Street, London , EC1V 9EL
Research Domain: Basic Life Sciences, Cardiometabolic Science, Experimental Medicine, Infection, Immunology & Inflammation, Neuroscience, Personalised Medicine Web Page: Personal Web Page

Profile

Research Description

Research into the role the vascular endothelium plays in the pathogenesis of brain and retinal disease is a core component of the laboratory. Work from the Greenwood laboratory has been at the forefront of identifying and characterising novel endothelial cell mechanisms that facilitate the recruitment of leukocytes to the brain and retina, a critical step in the pathogenesis of diseases such as multiple sclerosis and posterior uveitis. Our understanding of these cellular mechanisms remains superficial and ongoing research is aimed at identifying key biochemical pathways that can be targeted through pharmacological intervention.

In recent years considerable effort has also been directed towards identifying novel drivers of vascular pathology in the brain and retina and in particular factors that contribute to the development of neovascularisation and vessel remodelling. This work has led to the identification of a number of secreted polypeptides that contribute to angiogenesis/remodelling including one that modifies TGFβ signalling. This work is currently leading to the development and testing of novel inhibitors that may prevent aberrant vascular development in diseases such as neovascular age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR) where new blood vessel growth is a major cause of vision loss. 

Understanding the role of retinal pigment epithelial (RPE) cells in the development of retinal diseases constitutes the other major focus of the Greenwood laboratory. Recently we have been investigating the ability of RPE cells to trans-differentiate towards a neuronal phenotype, to investigate the role of
RPE in innate immunity and in the development of AMD, and to understand at the molecular level the mechanism of phagocytosis.


Research Activities

Differentiation of polarised epithelia

Mechanisms regulating lymphocyte differentiation i

Signal Transduction in Vascular Endothelial Cells

Education Description





UCL Collaborators

Prof Dame Linda Partridge; Prof David Gems; Dr Virginia Calder; Prof Mala Maini; Prof Nigel Klein; Prof Philip Luthert; Prof Arne Akbar; Dr Patric Turowski; Prof Dominic Withers; Dr Marcus Fruttiger; Prof Robin Ali; Prof Karl Matter; Prof Maria Balda; Prof James Bainbridge

External Collaborators

Publications

    2014

    • Martinelli R, Zeiger AS, Withfield M, Van Vliet KJ, Greenwood J, Carman CV (2014). Cellular and biomechanical determinants of leukocyte diapedesis migration route. ANGIOGENESIS, 17(1), 299 - 299.

    2013

    • Martinelli R, Newton G, Carman CV, Greenwood J, Luscinskas FW (2013). Novel Role of CD47 in Rat Microvascular Endothelium: Signaling and Regulation of T-Cell Transendothelial Migration.. Arterioscler Thromb Vasc Biol, , - . doi:10.1161/ATVBAHA.113.301903
    • Williams JA, Greenwood J, Moss SE (2013). Retinal changes precede visual dysfunction in the complement factor h knockout mouse.. PLoS One, 8(7), e68616 - . doi:10.1371/journal.pone.0068616
    • Wang X, Abraham S, McKenzie JA, Jeffs N, Swire M, Tripathi VB, Luhmann UF, Lange CA, Zhai Z, Arthur HM, Bainbridge JW, Moss SE, Greenwood J (2013). LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.. Nature, 499(7458), 306 - 311. doi:10.1038/nature12345

    2012

    • Martins T, Burgoyne T, Kenny BA, Hudson N, Futter CE, Ambrosio AF, Silva AP, Greenwood J, Turowski P (2012). Methamphetamine-induced nitric oxide promotes vesicular transport in blood-brain barrier endothelial cells.. Neuropharmacology, in press, - . doi:10.1016/j.neuropharm.2012.08.021
    • Faber C, Williams J, Juel HB, Greenwood J, Nissen MH, Moss SE (2012). Complement Factor H Deficiency Results in Decreased Neuroretinal Expression of Cd59a in Aged Mice. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 53(10), 6324 - 6330. doi:10.1167/iovs.12-10385
    • Chataway J, Alsanousi A, Chan D, MacManus D, Hunter K, Foster J, Bangham C, Wilkie D, Nicholas J, Clegg S, Nielsen C, Scheurer N, Calder V, Greenwood J, Frost C, Nicholas R (2012). The MS-STAT trial: high dose simvastatin demonstrates neuroprotection without immune-modulation in secondary progressive multiple sclerosis (SPMS) - a phase II trial.
    • McKenzie JA, Fruttiger M, Abraham S, Lange CA, Stone J, Gandhi P, Wang X, Bainbridge J, Moss SE, Greenwood J (2012). Apelin is required for non-neovascular remodeling in the retina.. Am J Pathol, 180(1), 399 - 409. doi:10.1016/j.ajpath.2011.09.035
    • Chataway J, Alsanousi A, Chan D, Macmanus D, Hunter K, Foster J, Bangham C, Wilkie D, Nicholas J, Calder V, Greenwood J, Frost C, Nicholas R (2012). The MS-STAT trial: a randomised placebo-controlled phase II trial of high dose simvastatin in secondary progressive multiple sclerosis (SPMS).

    2011

    • Alpizar YA, Chain B, Collins MK, Greenwood J, Katz D, Stauss HJ, Mitchison NA (2011). Ten years of progress in vaccination against cancer: the need to counteract cancer evasion by dual targeting in future therapies.. Cancer Immunol Immunother, 60(8), 1127 - 1135. doi:10.1007/s00262-011-0985-7
    • Lueck K, Wasmuth S, Williams J, Hughes TR, Morgan BP, Lommatzsch A, Greenwood J, Moss SE, Pauleikhoff D (2011). Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration. EYE, 25(8), 1074 - 1082. doi:10.1038/eye.2011.109
    • Carr AJ, Vugler AA, Yu L, Semo M, Coffey P, Moss SE, Greenwood J (2011). The expression of retinal cell markers in human retinal pigment epithelial cells and their augmentation by the synthetic retinoid fenretinide.. Mol Vis, 17, 1701 - 1715.
    • Greenwood J, Heasman SJ, Alvarez JI, Prat A, Lyck R, Engelhardt B (2011). Review: leucocyte-endothelial cell crosstalk at the blood-brain barrier: a prerequisite for successful immune cell entry to the brain.. Neuropathol Appl Neurobiol, 37(1), 24 - 39. doi:10.1111/j.1365-2990.2010.01140.x

    2010

    • Hasan SM, Vugler AA, Miljan EA, Sinden JD, Moss SE, Greenwood J (2010). Immortalized human fetal retinal cells retain progenitor characteristics and represent a potential source for the treatment of retinal degenerative disease.. Cell Transplant, 19(10), 1291 - 1306. doi:10.3727/096368910X505477
    • Tsapara A, Luthert P, Greenwood J, Hill CS, Matter K, Balda MS (2010). The RhoA Activator GEF-H1/Lfc Is a TGF-β Target Gene and Effector that Regulates α-Smooth Muscle Actin Expression and Cell Migration. Molecular Biology of the Cell, , - . doi:10.1091/mbc.E09-07-0567
    • Agius E, Lacy K, Vukmanovic-Stejic M, Papageorgiou AP, Hall S, Reed JR, Curnow J, Taams LS, Jagger A, Fuentes-Duculan J, Buckley C, Salmon M, Krueger J, Greenwood J, Klein N, Rustin M, Akbar AN (2010). Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4(+) T cells during ageing.
    • Parmalee NL, Schubert C, Merriam JE, Allikmets K, Bird AC, Gillies MC, Peto T, Figueroa M, Friedlander M, Fruttiger M, Greenwood J, Moss SE, Smith LEH, Toomes C, Inglehearn CF, Allikmets R (2010). Analysis of candidate genes for macular telangiectasia type 2. MOL VIS, 16(289-90), 2718 - 2726.

    2009

    • Agius E, Lacy K, Vukmanovic-Stejic M, Papageorgiou P, Hall S, Reed JR, Curnow J, Taams LS, Jagger AL, Fuentes-Duculan J, Buckley C, Salmon M, Krueger J, Greenwood J, Klein N, Rustin M, Akbar AN (2009). Tumour necrosis factor-alpha synthesis by macrophages is impaired during secondary cutaneous immune responses in old subjects.
    • Martinelli R, Gegg M, Adamson P, Greenwood J, Turowski P (2009). ICAM-1–mediated Endothelial Nitric Oxide Synthase Activation via Calcium and AMP-activated Protein Kinase Is Required for Transendothelial Lymphocyte Migration. Molecular Biology of the Cell, 20, 995 - 1005.
    • Subileau EA, Rezaie P, Davies HA, Colyer FM, Greenwood J, Male DK, Romero IA (2009). Expression of chemokines and their receptors by human brain endothelium: implications for multiple sclerosis. J.Neuropathol.Exp.Neurol., 68(3), 227 - 240.
    • Law AL, Ling Q, Hajjar KA, Futter CE, Greenwood J, Adamson P, Wavre-Shapton ST, Moss SE, Hayes MJ (2009). Annexin A2 Regulates Phagocytosis of Photoreceptor Outer Segments in the Mouse Retina. Mol.Biol.Cell, , - .
    • Longbottom R, Fruttiger M, Douglas RH, Martinez-Barbera JP, Greenwood J, Moss SE (2009). Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors.. Proc Natl Acad Sci U S A, 106(44), 18728 - 18733. doi:10.1073/pnas.0902593106
    • Agius E, Lacy KE, Vukmanovic-Stejic M, Jagger AL, Papageorgiou AP, Hall S, Reed JR, Curnow SJ, Fuentes-Duculan J, Buckley CD, Salmon M, Taams LS, Krueger J, Greenwood J, Klein N, Rustin MH, Akbar AN (2009). Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging. J.Exp.Med., 206(9), 1929 - 1940. doi:10.1084/jem.20090896
    • Dodelet-Devillers A, Cayrol R, van Horssen J, Haqqani AS, de Vries HE, Engelhardt B, Greenwood J, Prat A (2009). Functions of lipid raft membrane microdomains at the blood-brain barrier. J.Mol.Med., 87(8), 765 - 774.

    2008

    • Turowski P, Martinelli R, Crawford R, Wateridge D, Papageorgiou A, Lampugnani MG, Gamp A, Vestweber D, Adamson P, Dejana E, Greenwood J (2008). Phosphorylation of Vascular Endothelial Cadherin Controls Lymphocyte Emigration.. Journal of Cell Science, 121(1), 29 - 37. doi:10.1242/10.1242/jcs.022681
    • Chataway J, Chan D, Anderson V, Polito B, Kallis C, Frost C, Calder V, Greenwood J, Nicholas R, MSTC (2008). The MS-STAT trial: a Phase II trial of high dose simvastatin in secondary progressive multiple sclerosis.
    • Turowski P, Martinelli R, Crawford R, Wateridge D, Papageorgiou AP, Lampugnani MG, Gamp AC, Vestweber D, Adamson P, Dejana E, Greenwood J (2008). Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration.. J Cell Sci, 121(Pt 1), 29 - 37. doi:10.1242/jcs.022681
    • Agius E, Lacy K, Vukmanovic-Stejic M, Papageorgiou AP, Curnow I, Greenwood J, Klein N, Rustin M, Akbar AN (2008). Decreased endothelial activation results in defective secondary T cell immunity in aging skin.
    • Agius E, Lacy K, Vukmanovic-Stejic M, Papageorgiou AP, Hall S, Reed JR, Curnow J, Salmon M, Greenwood J, Klein N, Rustin MHA, Akbar AN (2008). Decreased secondary cutaneous memory immune response in old skin due to lack of endothelial activation.

    2007

    • Vugler AA, Redgrave P, Hewson-Stoate NJ, Greenwood J, and Coffey PJ (2007). Constant illumination causes spatially discrete dopamine depletion in the normal and degenerate retina.. Journal of Chemical Neuroanatomy, 33(1), 9 - 22.
    • Gias C, Jones M, Keegan D, Adamson P, Greenwood J, Lund R, Martindale J, Johnston D, Berwick J, Mayhew J, and Coffey P (2007). Preservation of visual cortical function following retinal pigment epithelium transplantation in the RCS rat using optical imaging techniques.. European Journal of Neuroscience, 25(7), 1940 - 1948.
    • da Cruz L, Chen FK, Ahmado A, Greenwood J, Coffey P (2007). RPE transplantation and its role in retinal disease.. Progress in Retinal and Eye Research, 26(6), 598 - 635.
    • Couty JP, Rampon C, Leveque M, Laran-Chich MP, Bourdoulous S, Greenwood J, Couraud PO (2007). PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells. J.Neurochem., 103(2), 793 - 801.
    • Vugler AA, Redgrave P, Semo M, Lawrence J, Greenwood J, Coffey PJ (2007). Dopamine neurones form a discrete plexus with melanopsin cells in normal and degenerating retina. Experimental Neurology, 205(1), 26 - 35. doi:10.1016/j.expneurol.2007.01.032
    • Gias C, Jones M, Keegan D, Adamson P, Greenwood J, Lund R, Martindale J, Johnston D, Berwick J, Mayhew J, Coffey P (2007). Preservation of visual cortical function following retinal pigment epithelium transplantation in the RCS rat using optical imaging techniques.. Eur J Neurosci, 25(7), 1940 - 1948. doi:10.1111/j.1460-9568.2007.05459.x
    • Greenwood J, Mason JC (2007). Statins and the vascular endothelial inflammatory response. Trends Immunol., 28(2), 88 - 98.
    • Coffey PJ, Gias C, McDermott CJ, Lundh P, Pickering MC, Sethi C, Bird A, Fitzke FW, Maass A, Chen LL, Holder GE, Luthert PJ, Salt TE, Moss SE, Greenwood J (2007). Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction. Proceedings of the National Academy of Sciences of the United States of America, 104(42), 16651 - 16656. doi:10.1073/pnas.0705079104

    2006

    • Weber MS, Youssef S, Dunn SE, Prod'homme T, Neuhaus O, Stuve O, Greenwood J, Steinman L, Zamvil SS (2006). Statins in the treatment of central nervous system autoimmune disease. Journal of Neuroimmunology, 178(1-2), 140 - 148.
    • Greenwood J, Steinman L, Zamvil SS (2006). Statin therapy and autoimmune disease: from protein prenylation to immunomodulation. Nature Reviews Immunology, 6(5), 358 - 370.
    • Zambarakji HJ, Keegan DJ, Holmes TM, Halfyard AS, Villegas-Perez MP, Charteris DG, Fitzke FW, Greenwood J, Lund RD (2006). High resolution imaging of fluorescein patterns in RCS rat retinae and their direct correlation with histology.. Experimental Eye Research, 82(1), 164 - 171.

    2005

    • Gegg ME, Harry R, Hankey D, Zamabarakji H, Pryce G, Baker D, Adamson P, Calder V, Greenwood J (2005). Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction. The Journal of Immunology, 174(4), 2327 - 2335.
    • Weksler BB, Subileau EA, Perriere N, Charneau P, Holloway K, Leveque M, Tricoire-Leignel H, Nicotra A, Bourdoulous S, Turowski P, Male DK, Roux F, Greenwood J, Romero IA, Couraud PO (2005). Blood-brain barrier-specific properties of a human adult brain endothelial cell line. The FASEB Journal, 19(13), 1872 - 1874. doi:10.1096/fj.04-3458fje
    • Gegg ME, Harry R, Hankey D, Zambarakji H, Pryce G, Baker D, Adamson P, Calder V, Greenwood J (2005). Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction.. J Immunol, 174(4), 2327 - 2335.
    • Turowski P, Adamson P, Greenwood J (2005). Pharmacological targeting of ICAM-1 signaling in brain endothelial cells: potential for treating neuroinflammation. Cellular and Molecular Neurobiology, 25(1), 153 - 170. doi:10.1007/s10571-004-1380-0
    • Greenwood J, Wateridge DJ, Turowski P (2005). Endothelial ICAM-1- mediated signaling and its role during lymphocyte migration to the CNS parenchyma. In De Vries HE, Prat A (Ed.), The Blood-Brain Barrier and Its Microenvironment (pp. 243 - 265). : Taylor and Francis.

    2004

    • Amin S, Chong NH, Bailey TA, Zhang J, Knupp C, Cheetham ME, Greenwood J, Luthert PJ (2004). Modulation of Sub-RPE deposits in vitro: a potential model for age-related macular degeneration.. Investigative Ophthalmology and Visual Science, 45(5), 1281 - 1288. doi:10.1167/iovs.03-0671
    • Prieto P, Blaauboer BJ, de Boer AG, Boveri M, Cecchelli R, Clemedson C, Coecke S, Forsby A, Galla HJ, Garberg P, Greenwood J, Price A, Tahti H (2004). Blood-brain barrier in vitro models and their application in toxicology. The report and recommendations of ECVAM workshop 49.
    • Turowski P, Ockrim ZK, Adamson P, Hykin P, Greenwood J (2004). Mechanisms controlling permeability and junctional architecture of primary retinal endothelial cells in vitro.
    • Turowski P, Adamson P, Sathia J, Zhang JJ, Moss SE, Aylward GW, Hayes MJ, Kanuga N, Greenwood J (2004). Basement membrane-dependent modification of phenotype and gene expression in human retinal pigment epithelial ARPE-19 cells.. Investigative Ophthalmology and Visual Science, 45(8), 2786 - 2794. doi:10.1167/iovs.03-0943
    • Subileau EA, Davies H, Colyer F, Greenwood J, Male D, Romero I (2004). CXCL10 promotes the secretion of CXCL8 and CCL2 by human astrocytes and brain endothelial cells.
    • Bailey TA, Kanuga N, Romero IA, Greenwood J, Luthert PJ, Cheetham ME (2004). Oxidative stress affects the junctional integrity of retinal pigment epithelial cells.. Investigative Ophthalmology and Visual Science, 45(2), 675 - 684.

    2003

    • Balda MS, Greenwood J, Adamson P, Matter K (2003). Differentiation of retinal pigment epithelium: The role of the tight junction associated transcription factor ZONAB.
    • Romero IA, Radewicz K, Jubin E, Michel CC, Greenwood J, Couraud PO, Adamson P (2003). Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells. Neuroscience Letters, 344(2), 112 - 116.
    • Lyck R, Reiss Y, Gerwin N, Greenwood J, Adamson P, Engelhardt B (2003). T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells. BLOOD, 102(10), 3675 - 3683.
    • Greenwood J, Walters CE, Pryce G, Kanuga N, Beraud E, Baker D, Adamson P (2003). Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis. The FASEB Journal, 17(8), 905 - 907. doi:10.1096/fj.02-1014fje
    • Couraud PO, Greenwood J, Roux F, Adamson P (2003). Development and characterization of immortalized cerebral endothelial cell lines. In Nag S (Ed.), The blood-brain barrier: Biology and research protocols (pp. 351 - 366). : Humana Press.
    • Couraud PO, Greenwood J, Roux F, Adamson P (2003). Development and characterization of immortalized cerebral endothelial cell lines. Methods in Molecular Medicine, 89, 349 - 364.
    • Baker D, Adamson P, Greenwood J (2003). Potential of statins for the treatment of multiple sclerosis. The Lancet Neurology, 2(1), 9 - 10.
    • Adamson P, Greenwood J (2003). How do statins control neuroinflammation?. Inflammation Research, 52(10), 399 - 403.
    • Greenwood J, Amos CL, Walters CE, Couraud PO, Lyck R, Engelhardt B, Adamson P (2003). Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration. The Journal of Immunology, 171(4), 2099 - 2108.
    • Harkness KA, Sussman JD, Davies-Jones GA, Greenwood J, Woodroofe MN (2003). Cytokine regulation of MCP-1 expression in brain and retinal microvascular endothelial cells. Journal of Neuroimmunology, 142(1-2), 1 - 9.

    2002

    • Rezaie P, Trillo-Pazos G, Greenwood J, Everall IP, Male DK (2002). Motility and ramification of human fetal microglia in culture: an investigation using time-lapse video microscopy and image analysis. Experimental Cell Research, 274(1), 68 - 82.
    • Moss SE, Rubin G, Greenwood J, Sillito A (2002). UK government closes its eyes to medical needs. Nature, 420(6913), 268 - .
    • Gias C, Jones M, Keegan D, Adamson P, Greenwood J, Lund RD, Martindale J, Johnston D, Mayhew J, Coffey P (2002). Optical imagine demonstrates amelioration of cortical visual function in dystrophic rats following transplantation of human immortalised RPE cells.
    • Coffey PJ, Girman S, Wang SM, Hetherington L, Keegan DJ, Adamson P, Greenwood J, Lund RD (2002). Long-term preservation of cortically dependent visual function in RCS rats by transplantation. Nature Neuroscience, 5(1), 53 - 56. doi:10.1038/nn782
    • Walters CE, Pryce G, Hankey DJR, Sebti SM, Hamilton AD, Baker D, Greenwood J, Adamson P (2002). Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis. The Journal of Immunology, 168(8), 4087 - 4094.
    • Kanuga N, Winton HL, Beauchene L, Koman A, Zerbib A, Halford S, Couraud PO, Keegan D, Coffey P, Lund RD, Adamson P, Greenwood J (2002). Characterization of genetically modified human retinal pigment epithelial cells developed for in vitro and transplantation studies. Investigative Ophthalmology and Visual Science, 43(2), 546 - 555.
    • Kis B, Kaiya H, Nishi R, Deli MA, Abraham CS, Yanagita T, Isse T, Gotoh S, Kobayashi H, Wada A, Niwa M, Kangawa K, Greenwood J, Yamashita H, Ueta Y (2002). Cerebral endothelial cells are a major source of adrenomedullin. Journal of Neuroendocrinology, 14(4), 283 - 293.
    • Zerbib A, Porte S, Puel G, David A, Neuner-Jehle M, Paisant S, Martin F, Degeorges A, Greenwood J, Crouzet J (2002). Cell therapy: New genetically "immortalized" human RPE cell lines.
    • Greenwood J, Etienne-Manneville S, Adamson P, Couraud PO (2002). Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood-brain barrier. Vascular Pharmacology, 38(6), 315 - 322.
    • Adamson P, Wilbourn B, Etienne-Manneville S, Calder V, Beraud E, Milligan G, Couraud PO, Greenwood J (2002). Lymphocyte trafficking through the blood-brain barrier is dependent on endothelial cell heterotrimeric G-protein signaling. The FASEB Journal, 16(10), 1185 - 1194.
    • Galea E, Santizo R, Feinstein DL, Adamsom P, Greenwood J, Koenig HM, Pelligrino DA (2002). Estrogen inhibits NF kappa B-dependent inflammation in brain endothelium without interfering with I kappa B degradation. NeuroReport, 13(11), 1469 - 1472.
    • Romero IA, Amos CL, Greenwood J, Adamson P (2002). Ezrin and moesin co-localise with ICAM-1 in brain endothelial cells but are not directly associated. Molecular Brain Research, 105(1-2), 47 - 59.

    2001

    • Amos C, Romero IA, Schultze C, Rousell J, Pearson JD, Greenwood J, Adamson P (2001). Cross-linking of brain endothelial intercellular adhesion molecule (ICAM)-1 induces association of ICAM-1 with detergent-insoluble cytoskeletal fraction. Arteriosclerosis, thrombosis, and vascular biology, 21(5), 810 - 816.
    • Van der GA, Wouters D, Van Der Pol SM, Huizinga R, Ronken E, Adamson P, Greenwood J, Dijkstra CD, De Vries HE (2001). Reactive oxygen species enhance the migration of monocytes across the blood-brain barrier in vitro. The FASEB Journal, 15(10), 1852 - 1854.
    • Lund RD, Adamson P, Girman SV, Keegan D, Winton H, Kwan A, Beauchene L, Zerbib A, Hetherington L, Couraud PO, Coffey P, Greenwood J (2001). Subretinal transplantation of a genetically engineered human RPE cell line prevents visual loss in the RCS rat. Proceedings of the National Academy of Sciences of the United States of America, 98, 9942 - 9947. doi:10.1073/pnas.171266298
    • Kis B, Deli MA, Kobayashi H, Abraham CS, Yanagita T, Kaiya H, Isse T, Nishi R, Gotoh S, Kangawa K, Wada A, Greenwood J, Niwa M, Yamashita H, Ueta Y (2001). Adrenomedullin regulates blood-brain barrier functions in vitro. NeuroReport, 12(18), 4139 - 4142.
    • Coffey PJ, Hetherington L, Girman S, Wang S, Lund RD, Keegan D, Kanuga N, Adamson P, Greenwood J (2001). Visual acuity in RCS rats after Transplantation of Human Immortalised RPE Cells..

    2000

    • (2000). Interactions between brain endothelial cells and human T-cell leukemia virus type 1-infected lymphocytes:mechanisms of viral entry into the central nervous system. Journal of Virology, 74(13), 6021 - 6030.
    • (2000). ICAM-1-coupled cytoskeletal rearrangements and transendothelial lymphocyte migration involve intracellular calcium signaling in brain endothelial cell lines. The Journal of Immunology, 165(6), 3375 - 3383.
    • (2000). Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium. Brain, 123(4), 698 - 709.
    • (2000). Cyclic adenosine monophosphate regulates the expression of the intercellular adhesion molecule and the inducible nitric oxide synthase in brain endothelial cells. Journal of Cerebral Blood Flow and Metabolism, 20(4), 688 - 699.
    • (2000). Assignment of claudin-1 (CLDN1) to human chromosome 3q28-->q29 with somatic cell hybrids. Cytogenetics and Cell Genetics, 88(3-4), 217 - .
    • Coffey PJ, Hetherington L, Keegan D, Greenwood J, Lund RD (2000). Deterioration of visual tracking in RCS rats and effect of immortalised human RPE cell transplantation..

    1999

    • Regina A, Romero IA, Greenwood J, Adamson P, Bourre JM, Couraud PO, Roux F (1999). Dexamethasone regulation of P-glycoprotein activity in an immortalized rat brain endothelial cell line, GPNT. J NEUROCHEM, 73(5), 1954 - 1963.
    • (1999). Dexamethasone regulation of P-glycoprotein activity in rat brain endothelial cells. Journal of Neurochemistry, 73, 1954 - 1963.
    • Adamson P, Etienne S, Couraud PO, Calder V, Greenwood J (1999). Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a Rho-dependent pathway. The Journal of Immunology, 162, 2964 - 2973.

    1998

    • Fabian G, Szabo CA, Bozo B, Greenwood J, Adamson P, Deli MA, Joo F, Krizbai IA, Szucs M (1998). Expression of G-protein subtypes in cultured cerebral endothelial cells. NEUROCHEM INT, 33(2), 179 - 185.
    • Linke AT, Greenwood J, Campbell I, Luthert P, Male DK (1998). Strain specific variation in IFN-gamma inducible lymphocyte adhesion to rat brain endothelial cells. J NEUROIMMUNOL, 91(1-2), 28 - 32.
    • Etienne S, Adamson P, Greenwood J, Strosberg AD, Cazaubon S, Couraud PO (1998). ICAM-1 signaling pathways associated with Rho activation in microvascular brain endothelial cells. J IMMUNOL, 161(10), 5755 - 5761.

    1997

    • Bamforth SD, Lightman SL, Greenwood J (1997). Ultrastructural analysis of interleukin-1 beta-induced leukocyte recruitment to the rat retina.. Invest Ophthalmol Vis Sci, 38(1), 25 - 35.
    • Bamforth SD, Lightman SL, Greenwood J (1997). Interleukin-1 beta-induced disruption of the retinal vascular barrier of the central nervous system is mediated through leukocyte recruitment and histamine.. Am J Pathol, 150(1), 329 - 340.
    • Pryce G, Male D, Campbell I, Greenwood J (1997). Factors controlling T-cell migration across rat cerebral endothelium in vitro.. J Neuroimmunol, 75(1-2), 84 - 94.

    1996

    • Greenwood J, Pryce G, Devine L, Male DK, dos Santos WL, Calder VL, Adamson P (1996). SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics.. J Neuroimmunol, 71(1-2), 51 - 63.
    • Devine L, Lightman S, Greenwood J (1996). Lymphocyte migration across the anterior and posterior blood-retinal barrier in vitro.. Cell Immunol, 168(2), 267 - 275. doi:10.1006/cimm.1996.0075
    • Greenwood J, Bamforth SD, Jao F, Luthert PJ (1996). Intraocular glutamic acid injections lead to increased permeability of the blood-retinal barrier in rats..
    • Devine L, Lightman SL, Greenwood J (1996). Role of LFA-1, ICAM-1, VLA-4 and VCAM-1 in lymphocyte migration across retinal pigment epithelial monolayers in vitro.. Immunology, 88(3), 456 - 462.
    • Bamforth SD, Lightman S, Greenwood J (1996). The effect of TNF-alpha and IL-6 on the permeability of the rat blood-retinal barrier in vivo.. Acta Neuropathol, 91(6), 624 - 632.

    1995

    • Greenwood J, Wang Y, Calder VL (1995). Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off.. Immunology, 86(3), 408 - 415.

    1994

    • Luthert PJ, Greenwood J (1994). Selective closure of the vascular bed of an experimental glioma model during in situ saline perfusion.. Neuropathol Appl Neurobiol, 20(5), 448 - 453.

    1989

    • Greenwood J, Hazell AS, Luthert PJ (1989). The effect of a low pH saline perfusate upon the integrity of the energy-depleted rat blood-brain barrier.. J Cereb Blood Flow Metab, 9(2), 234 - 242. doi:10.1038/jcbfm.1989.34
    • Greenwood J, Hazell AS, Pratt OE (1989). The transport of leucine and aminocyclopentanecarboxylate across the intact, energy-depleted rat blood-brain barrier.. J Cereb Blood Flow Metab, 9(2), 226 - 233. doi:10.1038/jcbfm.1989.33

    1988

    • Greenwood J, Luthert PJ, Pratt OE, Lantos PL (1988). Hyperosmolar opening of the blood-brain barrier in the energy-depleted rat brain. Part 1. Permeability studies.. J Cereb Blood Flow Metab, 8(1), 9 - 15. doi:10.1038/jcbfm.1988.2

    • Turowski P, Hudson N, Blaber R, McKenzie JA, Martinelli R, Gill Y, Adamson P, Greenwood J (). MAP Kinases Direct ICAM-1 Signalling to Divergent Functions in Brain Microvascular Endothelium.. , , - .