Prof Michael Duchen

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Personal Profile

Name: Michael Duchen Email: m.duchen@ucl.ac.uk
Title: Prof Tel: 020 7679 3207
Department: Cell & Developmental Biology Fax:
Position: Professor of Physiology Address: Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT
Research Domain: Ageing, Basic Life Sciences, Biomedical Imaging (Frontier Disciplines), Cancer, Cardiometabolic Science, Neuroscience, Personalised Medicine Web Page: Personal Web Page

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Research Description

We are interested in a wide range of issues related to mitochondrial biology and cell signaling. Much of our current work is focused on interrelationships between calcium signaling, mitochondria and free radicals in cell physiology and pathophysiology. This work embraces questions about thecontributions of mitochondrial function to intracellular calcium signaling.

We are fascinated by the intimate dialogue between mitochondrial biology and cell signaling systems. How do cell signaling pathways impact on and regulate mitochondrial physiology? How do subtle changes in mitochondrial function affect the physiology of the cell? How are mitochondria in different cell types specialized to match the specialized differentiated function of the cells they inhabit? We are especially concerned to characterise the contributions of mitochondrial dysfunction to cell injury and cell death - by necrosis or apoptosis – that takes place in situations such as ischaemia, reperfusion injury and in the neurotoxicity mediated by glutamate or beta-amyloid. Another core theme again involving a complex dialogue is the mitochondrion as both a site and a target of oxidative stress and damage in disease models. Most of our work involves live cell fluorescence microscopy and imaging, including confocal, multiphoton and fast read-out cooled CCD instruments. All approaches have been adapted to allow the simultaneous or near simultaneous measurement of multiple variables - cytosolic calcium and mitochondrial potential, cytosolic calcium and mitochondrial calcium, NADH autofluorescence and cytosolic calcium or cytosolic magnesium and so on. 

We have a broad general interest in functional cellular imaging and in the development of new approaches to imaging aspects of cell function usingtargeted probes, GFP tagged proteins, FRET, FLIM and so on. 
Interests of the lab extend through a wide range of biological problems in which mitochondria are involved - in ischaemia reperfusion injury in the heart, in the role of mitochondrial function in fertility in the  mammalian egg (with John Carroll), in mitochondrial function and septic shock syndrome in liver, kidney and muscle, in mitochondrial biogenesis following exercise and training in muscle, and in mitochondrial dysfunction in beta cells in diabetes. This rather unusual breadth has had a positive influence on all our work, as resolving problems in one system invariably seems to illuminate problems with others. We have been astonished at the frequency with which a small number of basic principles are recapitulated in a wide and disparate array of models. 

For recent reviews, see: 






Research Activities

A systematic investigation into the pathogenesis and course of Parkinson's syndrome

Autonomic neuroscience

Calcium signalling and mitochondrial function in cell physiology and pathophysiology.

Cell signalling

Intracellular and intercellular signalling mechanisms in health and disease

Paediatric Neurology

Regulation and targeting of the hypoxia inducible factor (HIF) pathway

The central nervous system regulation of energy homeostasis

The neurogenetics of neurodegenerative disease

The role of mitochondria in cardioprotection

critical care

Education Description

UCL Collaborators

Dr Jonathan Gale; Prof Barbara Pedley; Prof David Gems; Prof Adrian Thrasher; Dr Geoffrey Bellingan; Prof Sir Salvador Moncada; Prof Dame Linda Partridge; Dr Eugene Schuster; Prof Tarek Yousry; Dr Sean Davidson; Dr Paola Pedarzani; Prof John Hardy; Dr Jose Tomas Bras; Dr Laura Silveira Moriyama; Prof Tony Segal; Dr James Moon; Dr Andrey Abramov; Dr Mark Cooper; Prof Andrew Lees; Dr Brian King; Dr Helen Ling; Prof Derek Gilroy; Dr Jan-Willem Taanman; Dr Daniel Pearce; Prof Sebastian Brandner; Prof Elizabeth Fisher; Prof Mervyn Singer; Prof Dominic Withers; Dr Derek Hausenloy; Prof Patrick Maxwell; Prof Michael Spyer; Dr Derralynn Hughes; Prof Kailash Bhatia; Prof Mary Reilly; Prof William Mckenna; Prof Steve Wilson; Prof Tony Schapira; Dr Sally Dawson; Dr Rita Louro Guerreiro; Prof Chris Boshoff; Prof Stephen Caddick; Prof Stephen Moss; Prof Lucie Clapp; Prof Mark Lythgoe; Prof Nicholas Wood; Prof Tamas Revesz; Prof Linda Greensmith; Prof Martin Koltzenburg; Dr Babis Rallis; Dr Lazaros Foukas; Prof Francesco Muntoni; Prof Perry Elliott; Prof Jenny Morgan; Dr Rachel Batterham; Dr Nicolas Daudet

External Collaborators

Dr Dario Alessi; Dr James Martin Staddon; Dr Alexander James Whitworth; Dr Atul Mehta

Publications

    2014

    • Corona JC, Duchen MR (2014). PPARγ and PGC-1α as Therapeutic Targets in Parkinson's.. Neurochem Res, , - . doi:10.1007/s11064-014-1377-0
    • Bain AJ (2014). Separating NADH and NADPH fluorescence in live cells and tissues using FLIM. Nature Communications, 5, - . doi:10.1038/ncomms4936
    • Ivanes F, Faccenda D, Gatliff J, Ahmed AA, Cocco S, Cheng CH, Allan E, Russell C, Duchen MR, Campanella M (2014). The compound BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase.. Br J Pharmacol, , - . doi:10.1111/bph.12638
    • Levine AP, Duchen MR, Segal AW (2014). The HVCN1 channel conducts protons across the phagocytic vacuole of neutrophils. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 44, 16 - 16.
    • Logan CV, Sharpe JA, De Stefani D, Raffaello A, Rizzuto R, Duchen MR, Muntoni F, Sheridan E, Szabadkai G (2014). Genetic defects in mitochondrial calcium handling cause neuromuscular disease. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 44, 47 - 47.

    2013

    • Sajic M, Mastrolia V, Trigo D, Sadeghian M, Mosley AJ, Gregson NA, Duchen MR, Smith KJ (2013). Impulse conduction increases mitochondrial transport in adult mammalian peripheral nerves in vivo. PLoS Biology, 11(12), - . doi:10.1371/journal.pbio.1001754
    • Chlystun M, Campanella M, Law AL, Duchen MR, Fatimathas L, Levine TP, Gerke V, Moss SE (2013). Regulation of mitochondrial morphogenesis by annexin A6.. PLoS One, 8(1), e53774 - . doi:10.1371/journal.pone.0053774
    • Galvao J, Davis B, Tilley M, Normando E, Duchen MR, Cordeiro MF (2013). Unexpected low-dose toxicity of the universal solvent DMSO.. FASEB J, , - . doi:10.1096/fj.13-235440
    • Kotiadis VN, Duchen MR, Osellame LD (2013). Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health.. Biochim Biophys Acta, , - . doi:10.1016/j.bbagen.2013.10.041
    • Osellame LD, Duchen MR (2013). Quality Control Gone Wrong: Mitochondria, Lysosomal Storage Disorders and Neurodegeneration.. Br J Pharmacol, , - . doi:10.1111/bph.12453
    • Alfieri A, Srivastava S, Siow RC, Cash D, Modo M, Duchen MR, Fraser PA, Williams SC, Mann GE (2013). Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke.. Free Radic Biol Med, , - . doi:10.1016/j.freeradbiomed.2013.08.190
    • Faccenda D, Tan CH, Seraphim A, Duchen MR, Campanella M (2013). IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling.. Cell Death Differ, 20(5), 686 - 697. doi:10.1038/cdd.2012.163
    • Sadeghian M, Haddad AR, Mastrolia V, Schiza D, Sajic M, Duchen M, Smith K (2013). Loss of mitochondrial function and impaired mitochondrial trafficking at the onset of neurological deficits in a neuroinflammatory model of multiple sclerosis (MS) studied by in vivo confocal imaging.
    • Alfieri A, Srivastava S, Siow R, Modo M, Duchen M, Fraser P, Mann G (2013). Sulforaphane pre-treatment reduces blood-brain barrier disruption in experimental stroke by inducing heme oxygenase-1 expression in the glio-vascular complex of the peri-infarct region.
    • Cleeter MW, Chau KY, Gluck C, Mehta A, Hughes DA, Duchen M, Wood NW, Hardy J, Mark Cooper J, Schapira AH (2013). Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage.. Neurochem Int, 62(1), 1 - 7. doi:10.1016/j.neuint.2012.10.010
    • Zhou H, Rokach O, Feng L, Munteanu I, Mamchaoui K, Wilmshurst JM, Sewry C, Manzur AY, Pillay K, Mouly V, Duchen M, Jungbluth H, Treves S, Muntoni F (2013). RyR1 deficiency in congenital myopathies disrupts excitation-contraction coupling.. Hum Mutat, 34(7), 986 - 996. doi:10.1002/humu.22326
    • Logan CV, Szabadkai G, Sharpe JA, Parry DA, Torelli S, Childs AM, Kriek M, Phadke R, Johnson CA, Roberts NY, Bonthron DT, Pysden KA, Whyte T, Munteanu I, Foley AR, Wheway G, Szymanska K, Natarajan S, Abdelhamed ZA, Morgan JE, Roper H, Santen GW, Niks EH, van der Pol WL, Lindhout D, Raffaello A, De Stefani D, den Dunnen JT, Sun Y, Ginjaar I, Sewry CA, Hurles M, Rizzuto R, UK10K Consortium , Duchen MR, Muntoni F, Sheridan E (2013). Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.. Nat Genet, , - . doi:10.1038/ng.2851
    • Faccenda D, Tan CH, Duchen MR, Campanella M (2013). Mitochondrial IF1 preserves cristae structure to limit apoptotic cell death signaling. CELL CYCLE, 12(16), 2530 - 2532. doi:10.4161/cc.25840
    • Osellame LD, Duchen MR (2013). Defective quality control mechanisms and accumulation of damaged mitochondria link Gaucher and Parkinson diseases.. Autophagy, 9(10), - .
    • Faccenda D, Tan CH, Duchen MR, Campanella M (2013). Mitochondrial IF 1 retains cristae composition to limit apoptotic cell death signaling.. Cell Cycle, 12(16), - .
    • Osellame LD, Duchen MR (2013). Lysosomal dysfunction caused by glucocerebrosidase loss causes mitochondrial dysfunction as a consequence of impaired autophagy.
    • Osellame LD, Rahim AA, Hargreaves IP, Gegg ME, Richard-Londt A, Brandner S, Waddington SN, Schapira AHV, Duchen MR (2013). Mitochondria and quality control defects in a mouse model of Gaucher disease - links to Parkinson’s Disease. Cell Metabolism, 17(6), 941-53. - 953.. doi:10.1016/j.cmet.2013.04.014
    • Corona JC, Duchen MR (2013). Rosiglitazone protects human neuron-like cells against complex I inhibition through improvement of mitochondrial function.
    • Corona JC, de Souza SC, Duchen MR (2013). PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1.. Exp Neurol, , - . doi:10.1016/j.expneurol.2013.12.012

    2012

    • Baruch N, Duchen M, Hanna MG (2012). Muscle degeneration in ion channel dysfunction.
    • Munteanu I, Zhou H, Hargreaves I, Yasukawa T, Duchen MR, Muntoni F (2012). Investigating mitochondria in cell culture models of core myopathies.
    • Osellame LD, Rahim A, Gegg ME, Waddington S, Schapira AHV, Duchen MR (2012). Accumulation of damaged mitochondria in neuropathic Gaucher disease, the most prevalent risk factor for Parkinson's disease, is due to defective cellular degradation machinery. doi:10.1016/j.bbabio.2012.06.217
    • Schwarzländer M, Murphy MP, Duchen MR, Logan DC, Fricker MD, Halestrap AP, Müller FL, Rizzuto R, Dick TP, Meyer AJ, Sweetlove LJ (2012). Mitochondrial 'flashes': a radical concept repHined.. Trends Cell Biol, 22(10), 503 - 508. doi:10.1016/j.tcb.2012.07.007
    • Abeti R, Duchen MR (2012). Activation of PARP by oxidative stress induced by β-amyloid: implications for Alzheimer's disease.. Neurochem Res, 37(11), 2589 - 2596. doi:10.1007/s11064-012-0895-x
    • Ding S, Riddoch-Contreras J, Abramov AY, Qi Z, Duchen MR (2012). Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca2+ transients and nitric oxide.. J Muscle Res Cell Motil, 33(5), 327 - 337. doi:10.1007/s10974-012-9318-5
    • Papkovskaia TD, Chau KY, Inesta-Vaquera F, Papkovsky DB, Healy DG, Nishio K, Staddon J, Duchen MR, Hardy J, Schapira AH, Cooper JM (2012). G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization.. Hum Mol Genet, 21(19), 4201 - 4213. doi:10.1093/hmg/dds244
    • Gandhi S, Vaarmann A, Yao Z, Duchen MR, Wood NW, Abramov AY (2012). Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease.. PLoS One, 7(5), e37564 - . doi:10.1371/journal.pone.0037564
    • Duchen MR (2012). Mitochondria, calcium-dependent neuronal death and neurodegenerative disease.. Pflugers Arch, 464(1), 111 - 121. doi:10.1007/s00424-012-1112-0
    • Girard M, Larivière R, Parfitt DA, Deane EC, Gaudet R, Nossova N, Blondeau F, Prenosil G, Vermeulen EG, Duchen MR, Richter A, Shoubridge EA, Gehring K, McKinney RA, Brais B, Chapple JP, McPherson PS (2012). Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS).. Proc Natl Acad Sci U S A, 109(5), 1661 - 1666. doi:10.1073/pnas.1113166109
    • Davidson SM, Yellon DM, Murphy MP, Duchen MR (2012). Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation.. Cardiovasc Res, 93(3), 445 - 453. doi:10.1093/cvr/cvr349
    • Davidson SM, Duchen MR (2012). Imaging mitochondrial calcium signalling with fluorescent probes and single or two photon confocal microscopy.. Methods Mol Biol, 810, 219 - 234. doi:10.1007/978-1-61779-382-0_14
    • Traba J, Del Arco A, Duchen MR, Szabadkai G, Satrústegui J (2012). SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering.. Cell Death Differ, 19(4), 650 - 660. doi:10.1038/cdd.2011.139
    • Sadeghian M, Mosely A, Mastrolia V, Mullali G, Bowen S, Sajic M, Duchen M, Smith K (2012). Mitochondrial fragmentation and loss of function at the onset of neurological deficit in a neuroinflammatory model of multiple sclerosis (MS) studied by in vivo imaging.
    • Zhou H, Feng L, Munteanu I, Duchen M, Treves S, Jungbluth H, Muntoni F (2012). RyR1 deficiency in congenital myopathies disrupts excitation-contraction coupling and induces the second calcium release system via IP3R.
    • Blacker TS, Mann ZF, Gale JE, Ziegler M, Bain AJ, Duchen MR (2012). Separation of NADPH and NADH Fluorescence Emission in Live Cells using Flim. BIOPHYSICAL JOURNAL, 102(3), 196A - 196A.
    • Osellame LD, Blacker TS, Duchen MR (2012). Cellular and molecular mechanisms of mitochondrial function.. Best Pract Res Clin Endocrinol Metab, 26(6), 711 - 723. doi:10.1016/j.beem.2012.05.003
    • Corona JC, Duchen MR (2012). Rosiglitazone protects differentiated SH-SY5Y cells against damage induced by rotenone through mitochondrial biogenesis and by anti-oxidative mechanisms. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1817, S68 - S68. doi:10.1016/j.bbabio.2012.06.192
    • Ding S, Riddoch-Contreras J, Abramov AY, Qi Z, Duchen MR (2012). Erratum to: Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca(2+) transients and nitric oxide.. J Muscle Res Cell Motil, 33(5), 339 - . doi:10.1007/s10974-012-9327-4
    • Davidson SM, Duchen MM, Yellon DM (2012). Slow calcium waves and redox changes precede mPTP opening occur during hypoxia and reoxygenation in the intact heart.

    2011

    • Abramov AY, Duchen MR (2011). Measurements of threshold of mitochondrial permeability transition pore opening in intact and permeabilized cells by flash photolysis of caged calcium.. Methods Mol Biol, 793, 299 - 309. doi:10.1007/978-1-61779-328-8_19
    • Hall AM, Crawford C, Unwin RJ, Duchen MR, Peppiatt-Wildman CM (2011). Multiphoton imaging of the functioning kidney.. J Am Soc Nephrol, 22(7), 1297 - 1304. doi:10.1681/ASN.2010101054
    • Duchen MR, Heath K, Baruch NB, Hanna MG, Muntoni F (2011). Dysregulation of calcium and mitochondrial function as potential therapeutic targets in muscle disease.
    • Girard M, Lariviere R, Parfitt D, Deane E, Gaudet R, Blondeau F, Prenosil G, Vermeulen E, Duchen M, Gehring K, McKinney A, Brais B, Chapple J, McPherson P (2011). Mitochondrial dysfunction and Purkinje cell loss in the human spastic ataxia ARSACS..
    • Abeti R, Abramov AY, Duchen MR (2011). Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death.. Brain, 134(Pt 6), 1658 - 1672. doi:10.1093/brain/awr104
    • Abramov AY, Ionov M, Pavlov E, Duchen MR (2011). Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer's disease.. Aging Cell, 10(4), 595 - 603. doi:10.1111/j.1474-9726.2011.00685.x

    2010

    • Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW (2010). The large-conductance Ca2+-activated K+ channel is essential for innate immunity (Retraction of vol 427, pg 853, 2004). NATURE, 468(7320), 122 - 122. doi:10.1038/nature09562
    • Duchen MR, Szabadkai G (2010). Roles of mitochondria in human disease.. Essays Biochem, 47, 115 - 137. doi:10.1042/bse0470115
    • Hall AM, Campanella M, Loesch A, Duchen MR, Unwin RJ (2010). Albumin uptake in OK cells exposed to rotenone: a model for studying the effects of mitochondrial dysfunction on endocytosis in the proximal tubule?. Nephron Physiol, 115(2), p9 - p19. doi:10.1159/000314540
    • Igosheva N, Abramov AY, Poston L, Eckert JJ, Fleming TP, Duchen MR, McConnell J (2010). Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes.. PLoS One, 5(4), e10074 - . doi:10.1371/journal.pone.0010074
    • Averaimo S, Milton RH, Duchen MR, Mazzanti M (2010). Chloride intracellular channel 1 (CLIC1): Sensor and effector during oxidative stress.. FEBS Lett, 584(10), 2076 - 2084. doi:10.1016/j.febslet.2010.02.073
    • Munteanu I, Yasukawa T, Duchen MR, Muntoni F (2010). Uncovering the role of mitochondria in the pathogenesis of core myopathies.
    • Ng KE, Schwarzer S, Duchen MR, Tinker A (2010). The intracellular localization and function of the ATP-sensitive K+ channel subunit Kir6.1.. J Membr Biol, 234(2), 137 - 147. doi:10.1007/s00232-010-9241-x
    • Abramov AY, Smulders-Srinivasan TK, Kirby DM, Acin-Perez R, Enriquez JA, Lightowlers RN, Duchen MR, Turnbull DM (2010). Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations.. Brain, 133(Pt 3), 797 - 807. doi:10.1093/brain/awq015
    • Abramov AY, Duchen MR (2010). Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons.. Biochimica et Biophysica Acta (BBA) - General Subjects, , - . doi:10.1016/j.bbagen.2009.08.002
    • Traba J, Amigo I, Rueda C, Szabadkai G, Duchen MR, Satrustegui J, del Arco A (2010). The Ca2+-dependent ATP-Mg/Pi carriers as novel regulators of the mitochondrial permeability transition pore. doi:10.1016/j.bbabio.2010.04.386
    • El-Kadi AM, Bros-Facer V, Deng W, Philpott A, Stoddart E, Banks G, Jackson GS, Fisher EM, Duchen MR, Greensmith L, Moore AL, Hafezparast M (2010). The legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease.. J Biol Chem, 285(24), 18627 - 18639. doi:10.1074/jbc.M110.129320

    2009

    • Dumollard R, Carroll J, Duchen MR, Campbell K, Swann K (2009). Mitochondrial function and redox state in mammalian embryos.. Seminars in Cell and Developmental Biology, 20(3), 346 - 353.
    • Szabadkai G, Duchen MR (2009). Mitochondria mediated cell death in diabetes.. Apoptosis, , - . doi:10.1007/s10495-009-0363-5
    • Campanella M, Seraphim A, Abeti R, Casswell E, Echave P, Duchen MR (2009). IF1, the endogenous regulator of the F(1)F(o)-ATPsynthase, defines mitochondrial volume fraction in HeLa cells by regulating autophagy.. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1787(5), 393 - 401. doi:10.1016/j.bbabio.2009.02.023
    • Zolfaghari P, Singer M, Duchen MR (2009). UNCOUPLING PROTEIN-3 MEDIATES THE LOSS OF MITOCHONDRIAL MEMBRANE POTENTIAL IN SEVERE SEPSIS.
    • Echave P, Machado-da-Silva G, Arkell RS, Duchen MR, Jacobson J, Mitter R, Lloyd AC (2009). Extracellular growth factors and mitogens cooperate to drive mitochondrial biogenesis.. Journal of Cell Science, 122(24), 4516 - 4525.
    • Gandhi S, Wood-Kaczmar A, Wood NW, Duchen MR, Abramov AY (2009). PINK1 associated Parkinson's disease is caused by neuronal vulnerability to calcium induced cell death.
    • Gandhi S, Wood-Kaczmar A, Yao Z, Plun-Favreau H, Deas E, Klupsch K, Downward J, Latchman DS, Tabrizi SJ, Wood NW, Duchen MR, Abramov AY (2009). PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Molecular Cell, 33(5), 627 - 638. doi:10.1016/j.molcel.2009.02.013
    • Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AY, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Downward J, Mansfield L, Jat P, Taylor J, Heales S, Duchen MR, Latchman D, Tabrizi SJ, Wood NW (2009). PINK1 is necessary for long term survival and mitochondrial function in primary human dopaminergic neurons.
    • Campanella M, Parker N, Tan CH, Hall AM, Duchen MR (2009). IF(1): setting the pace of the F(1)F(o)-ATP synthase.. Trends in Biochemical Sciences, , - .
    • Hall AM, Unwin RJ, Parker N, Duchen MR (2009). Multiphoton imaging reveals differences in mitochondrial function between nephron segments.. Journal of the American Society of Nephrology, 20(6), 1293 - 1302.
    • Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten SK, Asare-Anane H, Batterham RL, Herrera PL, Persaud SJ, Duchen MR, Maxwell PH, Withers DJ (2009). Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.. Journal of Clinical Investigation, 119(1), 125 - 135. doi:10.1172/JCI26934
    • Mann ZF, Duchen MR, Gale JE (2009). Mitochondria modulate the spatio-temporal properties of intra- and intercellular Ca2+ signals in cochlear supporting cells.. Cell Calcium, 46(2), 136 - 146. doi:10.1016/j.ceca.2009.06.005
    • Galkin A, Abramov AY, Frakich N, Duchen MR, Moncada S (2009). Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?. J Biol Chem, 284(52), 36055 - 36061. doi:10.1074/jbc.M109.054346

    2008

    • Duchen MR, Verkhratsky A M, S (2008). Mitochondria and calcium in health and disease. Cell Calcium, , - .
    • Szabadkai G, Duchen MR (2008). Mitochondria: the hub of cellular Ca2+ signaling.. Physiology (Bethesda), 23(2), 84 - 94.
    • Bilsland LG, Nirmalananthan N, Yip J, Greensmith L, Duchen MR (2008). Expression of mutant SOD1G93A in astrocytes induces functional deficits in motoneuron mitochondria. Journal of Neurochemistry, 107(5), 1271 - 1283. doi:10.1111/j.1471-4159.2008.05699.x
    • Abramov AY, Duchen MR (2008). Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1777(7-8), 953 - 964. doi:10.1016/j.bbabio.2008.04.017
    • Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov AY, Tinker A, Duchen MR (2008). Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1.. Cell Metabolism, 8(1), 13 - 25. doi:10.1016/j.cmet.2008.06.001
    • Hall AM, Unwin RJ, Hanna MG, Duchen MR (2008). Renal function and mitochondrial cytopathy (MC): more questions than answers?. QJM, 101(10), 755 - 766. doi:10.1093/qjmed/hcn060
    • Szabadkai G, Duchen MR (2008). Mitochondria: The hub of cellular Ca2+ signaling (vol 23, pg 84, 2008). PHYSIOLOGY, 23(4), 230 - 230. doi:10.1152/physiol.00101.2008
    • Tan CH, Campanella M, Seraphim A, Farah Z, Conte A, Duchen MR (2008). The inhibitory protein 1F(1) regulates cellular sensitivity to staurosporine-induced cell death. doi:10.1016/j.bbabio.2008.05.331
    • Milton RH, Abeti R, Averaimo S, DeBiasi S, Vitellaro L, Jiang L, Curmi PM, Breit SN, Duchen MR, Mazzanti M (2008). CLIC1 function is required for beta-amyloid-induced generation of reactive oxygen species by microglia.. J Neurosci, 28(45), 11488 - 11499. doi:10.1523/JNEUROSCI.2431-08.2008
    • Davidson SM, Duchen M, Yellon DM (2008). Using multiphoton microscopy to examine the response of the heart to ischaemia and reperfusion injury. doi:10.1016/j.yjmcc.2008.02.160
    • Campanella M, Tan C, Abramov A, Tinker A, Duchen M (2008). Mitochondria as ATP consumers: the cell biology of the endogenous inhibitory protein, IF1. doi:10.1016/j.bbabio.2008.05.299
    • Wood-Kaczmar A, Gandhi S, Yao Z, Abramov ASY, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Deas E, Downward J, Mansfield L, Jat P, Taylor J, Heales S, Duchen MR, Latchman DL, Tabrizi SJ, Wood NW (2008). PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS ONE, 3(6), e2455 - . doi:10.1371/journal.pone.0002455

    2007

    • Dumollard R, Ward Z, Carroll J, Duchen MR (2007). Regulation of redox metabolism in the mouse oocyte and embryo. Development, 134(3), 455 - 465.
    • Dumollard R, Duchen M, Carroll J (2007). The role of mitochondrial function in the oocyte and embryo.. Current Topics in Developmental Biology, 77, 21 - 49.
    • Abramov AY, Scorziello A, Duchen MR (2007). Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. Journal of Neuroscience, 27, 1129 - 1138. doi:10.1523/JNEUROSCI.4468-06.2007
    • Abramov A, Fraley C, Diao C, Winkfein R, Duchen M, French R, Pavlov E (2007). Polyphosphate in mitochondrial function..
    • Abramov AY, Fraley C, Diao CT, Winkfein R, Colicos MA, Duchen MR, French RJ, Pavlov E (2007). Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death.. Proceedings of the National Academy of Sciences of the United States of America, 104(46), 18091 - 18096.
    • Davidson SM, Duchen MR (2007). Endothelial mitochondria: contributing to vascular function and disease. Circ Res., 100(8), 1128 - 1141.
    • Davidson SM, Yellon D, Duchen MR (2007). Assessing mitochondrial potential, calcium, and redox state in isolated mammalian cells using confocal microscopy. Methods Mol.Biol, 372, 421 - 430.
    • Ogston N, Hosseinzadeh-Attar M, Duchen M, Horakova O, Kopecky J, Johnston S, Speakman J, Fry C, Mohamed-Ali V (2007). Prostacyclin synthase activity regulates the adipose depot specific IL-6 secretion.
    • Ogston NC, Sharpe MA, Flachs P, Ricquier D, Kopecky J, Duchen MR, Mohamed-Ali V (2007). Uncoupling protein-2 expression and activity in white adipocytes: modulation of mitochondrial membrane potential and cellular redox state in response to lipid load and reactive oxygen species. DIABETIC MED, 24, 41 - 41.
    • Campanella M, Tinker A, Duchen MR (2007). Studies of the endogenous inhibitor of the mitochondrial ATPase, IFt, in intact cells..
    • McKenzie M, Liolitsa D, Akinshina N, Campanella M, Sisodiya S, Hargreaves I, Nirmalananthan N, Sweeney MG, Abou-Sleiman PM, Wood NW, Hanna MG, Duchen MR (2007). Mitochondrial ND5 gene variation associated with encephalomyopathy and mitochondrial ATP consumption. Journal of Biological Chemistry, 282(51), 36845 - 36852. doi:10.1074/jbc.M704158200

    2006

    • Brennan JP, Berry RG, Baghai M, Duchen MR, Shattock MJ (2006). FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation.. Cardiovascular Research, 72(2), 322 - 330. doi:10.1016/j.cardiores.2006.08.006
    • Davidson SM, Duchen MR (2006). Effects of NO on mitochondrial function in cardiomyocytes: Pathophysiological relevance. Cardiovasc.Res., 71(1), 10 - 21.
    • Davidson SM, Duchen MR (2006). Calcium microdomains and oxidative stress.. Cell Calcium, 40(5), 561 - 574. doi:10.1016/j.ceca.2006.08.017
    • Davidson SM, Hausenloy D, Duchen MR, Yellon DM (2006). Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection. The International Journal of Biochemistry and Cell Biology, 38(3), 414 - 419. doi:10.1016/j.biocel.2005.09.017
    • Brennan JP, Southworth R, Medina RA, Davidson SM, Duchen MR, Shattock MJ (2006). Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation.. Cardiovascular Research, 72(2), 313 - 321. doi:10.1016/j.cardiores.2006.07.019
    • Smart N, Mojet MH, Latchman DS, Marber MS, Duchen MR, Heads RJ (2006). IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes. Cardiovascular Research, 69, 164 - 177.
    • Jia HY, Bagherzadeh A, Bicknell R, Duchen MR, Liu D, Zachary I (2006). Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells (vol 279, pg 36148, 2004). J BIOL CHEM, 281(8), 5328 - 5328.
    • Dumollard R, Duchen M, Sardet C (2006). Calcium signals and mitochondria at fertilisation.. Seminars in Cell and Developmental Biology, 17(2), 314 - 323. doi:10.1016/j.semcdb.2006.02.009
    • Dumollard R, Z C, J D, M R (2006). Regulation of redox metabolism in the mouse oocyte and embryo. Development, , - . doi:10.1242/dev.02744

    2005

    • Abramov AY, Jacobson J, Wientjes F, Hothersall J, Canevari L, Duchen MR (2005). Expression and modulation of an NADPH oxidase in mammalian astrocytes. Journal of Neuroscience, 25(40), 9176 - 9184. doi:10.1523/JNEUROSCI.1632-05.2005
    • Shanmuganathan S, Hausenloy DJ, Duchen MR, Yellon DM (2005). Inhibiting mitochondrial permeability transition pore as a target for cardioprotection in the human heart. American Journal of Physiology - Heart and Circulatory Physiology, 289(1), H237 - H242.
    • Abramov AY, Duchen MR (2005). The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides.. Philosophical Transactions of the Royal Society B: Biological Sciences, 360(1464), 2309 - 2314.
    • Pitter JG, Szanda G, Duchen MR, Spat A (2005). Prostaglandin F2alpha potentiates the calcium dependent activation of mitochondrial metabolism in luteal cells.. Cell Calcium, 37(1), 35 - 44.
    • Jacobson J, Duchen MR, Hothersall J, Clark JB, Heales SJ (2005). Induction of mitochondrial oxidative stress in astrocytes by nitric oxide precedes disruption of energy metabolism. Journal of Neurochemistry, 95(2), 388 - 395.
    • Abramov AY, Canevari L, Duchen MR (2005). Expression, function and modulation of an NADPH oxidase in mammalian astrocytes.
    • Liolitsa D, McKenzie M, Hargreaves I, Heales S, Land J, Sisodiya SM, Wood NW, Duchen MR, Hanna MG (2005). MELAS, a young-onset stroke disorder associated with a homoplasmic ND5 mitochondrial DNA mutation. EUR J NEUROL, 12, 158 - 159.
    • Kouri K, Duchen MR, Lemmens-Gruber R (2005). Effects of beauvericin on the metabolic state and ionic homeostasis of ventricular myocytes of the guinea pig.. Chemical Research in Toxicology, 18(11), 1661 - 1668.
    • Abrarnov AY, Wientjes F, Canevari L, Duchen MR (2005). An NADPH oxidase in astrocytes: Expression, function and pathophysiological role in the neurotoxicity of beta amyloid.
    • Abramov AY, Duchen MR (2005). Mechanisms underlying the loss of mitochondrial potential calcium homeostasis in neurons during glutamate excitotoxicity.

    2004

    • Canevari L, Abramov AY, Duchen MR (2004). Toxicity of amyloid beta peptide: tales of calcium, mitochondria, and oxidative stress.. Neurochemical Research, 29(3), 637 - 650.
    • Rizzuto R, Duchen MR, Pozzan T (2004). Flirting in little space: the ER/mitochondria Ca2+ liaison. Sci STKE, 215, re1, 13 - .
    • Jacobson J, Duchen MR (2004). Interplay between mitochondria and cellular calcium signalling.. Molecular and Cellular Biochemistry, 256-257(1-2), 209 - 218.
    • Hausenloy DJ, Yellon DM, Mani-Babu S, Duchen MR (2004). Preconditioning protects by inhibiting the mitochondrial permeability transition.. American Journal of Physiology - Heart and Circulatory Physiology, 287(2), H841 - H849.
    • Abramov AY, Canevari L, Duchen MR (2004). Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. Journal of Neuroscience, 24(2), 565 - 575. doi:10.1523/JNEUROSCI.4042-03.2004
    • Abramov AY, Canevari L, Duchen MR (2004). Calcium signals induced by amylold beta peptide and their consequences in neurons and astrocytes in culture. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1742(1-3), 81 - 87.
    • Jia H, Bagherzadeh A, Bicknell R, Duchen MR, Liu D, Zachary I (2004). Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells.. Journal of Biological Chemistry, 279(34), 36148 - 36157. doi:10.1074/jbc.M401538200
    • Hausenloy D, Wynne A, Yellon DM, Duchen M (2004). Does the mitochondrial permeability transition have a role in preconditioning? Response.
    • Shanmuganathan S, Hausenloy DJ, Duchen MR, Yellon DM (2004). Inhibiting mitochondrial permeability transition pore opening protects the human myocardium from ischemia-reperfusion injury.
    • Surin AM, Storozhevykh TP, Vinskaya NP, Pinelis VG, Duchen MR, Khodorov BI (2004). Does mitochondrial ATp synthase reversal play a crucial role in glutamate-induced deterioration of Ca2+ homeostasis in mature hippocampal cultured neurons?. BIOL MEMBRANY, 21(2), 157 - 159.
    • Rizzuto R, Duchen MR, Pozzan T (2004). Flirting in little space: the ER/mitochondria Ca2+ liaison.. Sci STKE, 2004(215), re1 - . doi:10.1126/stke.2152004re1
    • Davidson SM, Hausenloy D, Duchen MR, Yellon DM (2004). Insulin inhibits opening of the mitochondrial permeability transition pore via the reperfusion injury salvage kinase (RISK) pathway.
    • Abramov AY, Canevari L, Duchen MR (2004). Amyloid beta peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase..
    • Hausenloy DJ, Wynne A, Duchen M, Yellon DM (2004). Does the mitochondrial permeability transition pore have a role in preconditioning?-letter to editor.
    • McKenzie M, Liolitsa D, Sisodiya S, Wood N, Duchen M, Hanna M (2004). A homoplasmic ND5 mutation associated with MELAS: mitochondria as ATP consumers?.
    • Duchen MR (2004). Roles of mitochondria in health and disease. Diabetes, 53(1), S96 - S102.
    • Hausenloy D, Wynne A, Duchen M, Yellon D (2004). Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection.. Circulation, 109(14), 1714 - 1717. doi:10.1161/01.CIR.0000126294.81407.7D
    • Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW (2004). The large-conductance Ca2+-activated K channel is essential for innate immunity.. Nature, 427(6977), 853 - 858. doi:10.1038/nature02356
    • Dumollard R, Marangos P, Fitzharris G, Swann K, Duchen M, Carroll J (2004). Sperm-triggered [Ca2+] oscillations and Ca2+ homeostasis in the mouse egg have an absolute requirement for mitochondrial ATP production.. Development, 131(13), 3057 - 3067. doi:10.1242/dev.01181
    • Duchen MR (2004). Mitochondria in health and disease: perspectives on a new mitochondrial biology. Molecular Aspects in Medicine, 25(4), 365 - 451.

    2003

    • Hausenloy D, Duchen MR, Yellon DM (2003). Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury.. Cardiovascular Research, 60(3), 617 - 625. doi:10.1016/j.cardiores.2003.09.025
    • Abramov AY, Duchen MR (2003). Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells.. Cell Calcium, 33(2), 101 - 112.
    • Monastyrskaya EA, Andreeva LV, Duchen MR, Manukhina EB, Malyshev IY (2003). Direct and cross-protective effects of heat adaptation in cultured cells.. Bulletin of Experimental Biology and Medicine, 135(2), 127 - 129.
    • Abramov AY, Canevari L, Duchen MR (2003). Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. Journal of Neuroscience, 23(12), 5088 - 5095.
    • Abramov AY, Canevari L, Duchen MR (2003). Amyloid beta peptide causes [Ca2+](c) fluctuations and decreases [GSH] in rat astrocytes..
    • Monastyrskaya EA, Duchen MR, Andreeva LV, Viegant F, Manukhina EB, Malyshev IY (2003). Antiapoptotic effect of heat adaptation in cultured cells.. Bulletin of Experimental Biology and Medicine, 135(2), 123 - 126.
    • Duchen MR (2003). Mitochondria and calcium signalling; point counter point. In Berridge M (Ed.), Handbook of Cell Signalling (pp. 73 - 77). : Elsevier.
    • Hausenloy DJ, Wynne AM, Duchen MR, Yellon DM (2003). Transient mitochondrial permeability transition pore opening mediates ischemic preconditioning-induced protection.
    • Monastyrskaya EA, Andreeva LV, Duchen MR, Wiegant F, Bayda LA, Manukhina EB, Malyshev IY (2003). Adaptation to heat of cardiomyoblasts in culture protects them against heat shock: role of nitric oxide and heat shock proteins.. Biochemistry (Moscow), 68(7), 816 - 821.
    • Duchen MR, Surin A, Jacobson J (2003). Imaging mitochondrial function in intact cells.. Biophotonics, Methods in Enzymology, 361(17), 353 - 389.

    2002

    • Krieger C, Duchen MR (2002). Mitochondria, Ca2+ and neurodegenerative disease.. European Journal of Pharmacology, 447(2-3), 177 - 188. doi:10.1016/S0014-2999(02)01842-3
    • Jacobson J, Duchen MR (2002). Mitochondrial oxidative stress and cell death in astrocytes--requirement for stored Ca2+ and sustained opening of the permeability transition pore. Journal of Cell Science, 115(6), 1175 - 1188.
    • Casley CS, Land JM, Sharpe MA, Clark JB, Duchen MR, Canevari L (2002). Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons. Neurobiology of Disease, 10(3), 258 - 267.
    • Robb SJ, Goss A, Duchen MR, Singer M (2002). Nitric oxide independent inhibition of the mitochondrial respiratory chain in HepG2 cells.
    • Brennan JP, Duchen MR, Shattock MJ (2002). The anti-ischemic effect of low-dose FCCP involves mitochondrial oxidation without detectable depolarisation. J MOL CELL CARDIOL, 34(6), A13 - A13.
    • Duchen MR, Surin AL (2002). On the roles of mitochondria and calcium in glutamate induced neurotoxicity in hippocampal neurons in culture. Membrane Cell Biology, 19, 4 - 16.
    • Duchen MR (2002). Roles of mitochondria, calcium and NO in glutamate excitotoxicity.
    • Robb SJ, Brealey D, Karyampudi S, Duchen MR, Bellingan G, Singer M (2002). Decrease in VO2 in renal tubules from septic rats relates to clinical severity and nitric oxide.
    • Mohamed-Ali V, Goodrick SJ, Erusalimsky JD, Mathur A, Sharpe M, Duchen MR (2002). Redox state, mitochondrial membrane potential and UCP expression in relation to lipid content in adipocytes. BIOPHYS J, 82(1), 344A - 344A.
    • Song G, Harding SE, Duchen MR, Tunwell R, O'Gara P, Hawkins TE, Moss SE (2002). Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice. The FASEB Journal, 16(6), 622 - 624.
    • Jacobson J, Duchen MR, Heales SJR (2002). Intracellular distribution of the fluorescent dye nonyl acridine orange responds to the mitochondrial membrane potential: implications for assays of cardiolipin and mitochondrial mass. Journal of Neurochemistry, 82(2), 224 - 233.
    • Hausenloy DJ, Mani-Babu S, Duchen MR, Yellon DM (2002). Mitochondrial KATP channel activation protects the myocyte against oxidative stress by inhibiting mitochondrial permeability transition pore opening.

    2001

    • Rakhit RD, Mojet MH, Marber MS, Duchen MR (2001). Mitochondria as targets for nitric oxide-induced protection during simulated ischemia and reoxygenation in isolated neonatal cardiomyocytes. Circulation, 103(21), 2617 - 2623.
    • Jacobson J, Duchen MR (2001). 'What nourishes me, destroys me': towards a new mitochondrial biology. Cell Death and Differentiation, 8(10), 963 - 966.
    • Duchen M, Mojet M, Jacobson DJ, Keelan J, Vergun O (2001). Imaging mitochondrial function in single cells. In Periasamy A (Ed.), Methods in Cellular Imaging (pp. 88 - 111). : American Physiological Society, Oxford University Press.
    • Keelan J, Allen NJ, Antcliffe D, Pal S, Duchen MR (2001). Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane. Journal of Neuroscience Research, 66(5), 873 - 884.
    • Jacobson J, Duchen MR, Clark JB, Heales SJR (2001). Assay of mitochondrial cardiolipin content in cortical astrocytes. J NEUROCHEM, 78, 25 - 25.
    • Vergun O, Sobolevsky AI, Yelshansky MV, Keelan J, Khodorov BI, Duchen MR (2001). Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture. The Journal of Physiology, 531, 147 - 163.
    • Duchen M, Abramov A (2001). Actions of Ca(2+) ionophores on mitochondria in intact cells.. BIOPHYSICAL JOURNAL, 80(1), 614A - 615A.

    2000

    • Beltran B, Mathur A, Duchen MR, Erusalimsky JD, Moncada S (2000). The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death. Proceedings of the National Academy of Sciences of the United States of America, 97(26), 14602 - 14607.
    • Duchen MR (2000). Mitochondria and calcium: from cell signalling to cell death. The Journal of Physiology, 529, 57 - 68.
    • Mojet M, Jacobson DJ, Keelan J, Vergun O, Duchen MR (2000). Monitoring mitochondrial function in single cells. In Tepikin A (Ed.), Calcium Signalling (pp. 79 - 110). : IRL Press,OUP.
    • Duchen MR (2000). Mitochondria and Ca2+ in cell physiology and pathophysiology . Cell Calcium, 28(5), 339 - 348.
    • Duchen MR (2000). Mitochondria and Ca(2+)in cell physiology and pathophysiology.. Cell Calcium, 28(5-6), 339 - 348. doi:10.1054/ceca.2000.0170
    • Keelan J, Allen NJ, Antcliffe D, Pal S, Heales S, Duchen MR (2000). Quantitative confocal microscopic measurement of glutathione levels in mixed hippocampal cultures. J PHYSIOL-LONDON, 525, 68P - 69P.
    • Duchen MR (2000). Symposium overview. The Journal of Physiology, 529, 2 - .

    1999

    • Song GJ, Harding SE, Duchen M, O'Gara P, Hawkins T, Moss SE (1999). Altered cardiomyocyte dynamics in annexin VI knockout mice. CIRCULATION, 100(18), 762 - 763.
    • Rakhit RD, Mojet MH, Duchen MR (1999). Mitochondrial depolarisation by nitric oxide protects against calcium overload injury during simulated ischemia-reperfusion.
    • Boitier E, Rea R, Duchen MR (1999). Mitochondria exert a negative feedback control on the propagation of intracellular [Ca2+]i waves in adult rat cortical astrocytes. The Journal of Cell Biology, 145, 795 - 808.
    • Duchen MR (1999). Mitochondrial contributions to animal physiology: from homeostatic sensor to calcium signalling and cell death. The Journal of Physiology, 516, 1 - 17.
    • Vergun O, Keelan J, Duchen MR (1999). Contribution of reactive oxygen species (ROS) to the mitochondrial depolarization and perturbation of calcium homeostasis associated with glutamate toxicity.
    • Rakhit RD, Mojet MH, Edwards RJ, Aldous A, Duchen MR, Marber MS (1999). Nitric oxide modulates mitochondrial function in neonatal cardiocytes by reversible inhibition of respiration.
    • Boitier E, Rea R, Duchen MR (1999). Modulation of the propagation of calcium waves by mitochondria in rat cortical astrocytes.
    • Keelan J, Vergun O, Duchen MR (1999). The synergistic action of calcium and nitric oxide causes mitochondrial depolarisation during toxic glutamate exposure in hippocampal neurones. The Journal of Physiology, 520(3), 797 - 813.
    • Mojet MH, Duchen MR (1999). Imaging transmission spectroscopy in the isolated carotid body (with simultaneous recordings of carotid sinus nerve activity).
    • Vergun O, Keelan J, Khodorov BI, Duchen MR (1999). Glutamate-induced mitochondrial depolarization and perturbation of calcium homeostasis in cultured rat hippocampal neurons. The Journal of Physiology, 519(1), 451 - 467.
    • Keelan J, Vergun O, Duchen MR (1999). Dynamics of intracellular calcium and mitochondrial potential during excitotoxicity in hippocampal neurons.
    • Duchen MR, Boitier E, Jacobson D, Keelan J, Vergun O (1999). Imaging mitochondrial function and cytosolic calcium in single mammalian cells.
    • Ashmore JF, Bolsover SR, Cockcroft S, Duchen MR, Koffer A, Moss SE, Swann K (1999). Imaging as applied to cell signalling: work from the Physiology Imaging Consortium (UCL.PIC).
    • Ibarreta D, Duchén M, Ma D, Qiao L, Kozikowski AP, Etcheberrigaray R (1999). Benzolactam (BL) enhances sAPP secretion in fibroblasts and in PC12 cells.. Neuroreport, 10(5), 1035 - 1040.
    • Keelan J, Vergun O, Duchen MR (1999). Excitotoxic mitochondrial depolarisation requires both calcium and nitric oxide in rat hippocampal neurons.. J Physiol, 520 Pt 3, 797 - 813.
    • Boitier E, Rea R, Duchen MR (1999). Mitochondria exert a negative feedback on the propagation of intracellular Ca2+ waves in rat cortical astrocytes.. J Cell Biol, 145(4), 795 - 808.
    • Duchen MR (1999). Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death.. J Physiol, 516 ( Pt 1), 1 - 17.

    1998

    • Morris SH, Keelan J, Patterson DL, Duchen MR, Bindman LJ (1998). Group I metabotropic glutamate receptor (mGluR) agonists raise intracellular [Ca2+] in medial frontal cortical neurones of the rat.
    • Nowicky AV, Duchen MR (1998). Changes in [Ca2+]i and membrane currents in response to impaired mitochondrial metabolism in dissociated rat hippocampal neurons. The Journal of Physiology, 507, 131 - 146.
    • Nowicky AV, Duchen MR (1998). Changes in [Ca2+]i and membrane currents during impaired mitochondrial metabolism in dissociated rat hippocampal neurons.. J Physiol, 507 ( Pt 1), 131 - 145.
    • Keelan J, Hersson-Ringskog J, Sioftanos G, Sritharan K, Vergun O, Duchen MR (1998). Nitric oxide contributes to glutamate-induced mitochondrial dysfunction in rat hippocampal neurones in culture. J PHYSIOL-LONDON, 511P, 122P - 123P.
    • Keelan J, Vergun O, Duchen MR (1998). Is there a role for the mitochondrial permeability transition in the initial stages of glutamate excitotoxicity?.
    • Vergun O, Khodorov B, Duchen MR (1998). Does mitochondrial function underlie the glutamate induced deterioration of neuronal calcium homeostasis?.
    • Duchen MR, Leyssens A, Crompton M (1998). Transient Mitochondrial Depolarizations Reflect Focal Sarcoplasmic Reticular Calcium Release in Single Rat Cardiomyocytes. The Journal of Cell Biology, 142(4), 975 - 988.
    • Keelan J, Vergun O, Khodorov B, Duchen MR (1998). Calcium-dependent mitochondrial depolarisation specific to toxic glutamate stimulation in cultured rat hippocampal neurones.
    • Keelan J, Vergun O, Hersson-Ringskog J, Sritharan K, Sioftanos G, Duchen MR (1998). Nitric oxide contributes to glutamate-induced mitochondrial dysfunction in rat hippocampal neurons in culture.
    • Duchen MR, Leyssens A, Crompton M (1998). Transient mitochondrial depolarisations in response to focal SR calcium release in single rat cardiomyocytes. The Journal of Cell Biology, 142, 975 - 988.
    • Jacobson D, Duchen MR (1998). Fluorescence imaging of the mitochondrial permeability transition in rat cortical astrocytes in culture.

    1997

    • Jacobsen D, Duchen MR (1997). Fluorescence imaging of the mitochondrial permeability transition in rat cortical astrocytes in culture.
    • Mojet MH, Mills E, Duchen MR (1997). Hypoxia-induced catecholamine secretion in isolated newborn rat adrenal chromaffin cells is mimicked by inhibition of mitochondrial respiration. The Journal of Physiology, 504(1), 175 - 189.
    • Duchen MR, Boitier E, Jacobsen D, Leyssens A, Peuchen S (1997). Mitochondria, free radicals and intracellular calcium in cell injury studied in single mammalian cells.
    • Peuchen S, Bolanos JP, Heales SJR, Almeida A, Duchen MR, Clark JB (1997). Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system. Progress in Neurobiology, 52(4), 261 - 281. doi:10.1016/S0301-0082(97)00010-5
    • Peuchen S, Duchen MR, Clark JB (1997). Modulation of gluthathione redox state in adult astrocytes.
    • Keelan J, Vergun O, Patterson DL, Duchen MR (1997). Excitotoxicity, cellular calcium signalling and mitochondrial (dys)function in cultured hippocampal neurons.
    • Peuchen S, Bolanos JP, Heales S, Duchen MR, Clark JB (1997). Interrelationships between astrocyte function, oxidative stress and antioxidant status in the CNS. Progress in Neurobiology, 52, 261 - 281.
    • Keelan J, Vergun O, Khodorov B, Duchen MR (1997). Calcium-dependent mitochondrial depolarisation specific to toxic glutamate stimulation in cultured rat hippocampal neurones.

    1996

    • Leyssens A, Crompton M, Duchen MR (1996). A role of the mitochondrial permeability transition pore in cell injury by reactive oxygen species in isolated rat cardiomyocytes.
    • Mojet MH, Mills E, Duchen MR (1996). Hypoxia-induced catecholamine secretion by adrenal chromaffin cells isolated from newborn rat is mediated by a fall in [ATP](i) and influx of extracellular Ca2+.
    • Duchen MR, Leyssens A, Mojet MH, Peuchen S (1996). Properties of rhod-2 as an indicator of intra-mitochondrial calcium.
    • Peuchen S, Duchen MR, Clark JB (1996). Modulation of the glutathione redox state in adult astrocytes.. Biochem Soc Trans, 24(3), 449S - .
    • Peuchen S, Duchen MR, Clark JB (1996). Energy metabolism of adult astrocytes in vitro.. Neuroscience, 71(3), 855 - 870.
    • Mojet MH, Mills E, Duchen MR (1996). Hypoxia-induced catecholamine secretion in adrenal chromaffin cells isolated from newborn rat. PROG BIOPHYS MOL BIO, 65, PC101 - PC101.
    • Peuchen S, Duchen MR, Clark JB (1996). Modulation of the glutathione redox state in adult astrocytes..
    • Duchen MR (1996). Raised intramitochondrial calcium stimulates ATP depletion by the mitochondrial F1F0-ATPase during metabolic inhibition in single mouse sensory neurons in culture. J PHYSIOL-LONDON, 491P, P134 - P134.
    • Leyssens A, Nowicky AV, Patterson L, Crompton M, Duchen MR (1996). The relationship between mitochondrial state, ATP hydrolysis, [Mg2+]i and [Ca2+]i studied in isolated rat cardiomyocytes.. J Physiol, 496 ( Pt 1), 111 - 128.
    • Peuchen S, Clark JB, Duchen MR (1996). Mechanisms of intracellular calcium regulation in adult astrocytes.. Neuroscience, 71(3), 871 - 883.

    1995

    • NOWICKY AV, DUCHEN MR (1995). INHIBITION OF MITOCHONDRIAL-FUNCTION INDUCES A CALCIUM-DEPENDENT POTASSIUM CURRENT IN DISSOCIATED RAT CA1 HIPPOCAMPAL-NEURONS. J PHYSIOL-LONDON, 487P, P60 - P60.
    • LEYSSENS A, NOWICKY AV, PATTERSON L, CROMPTON M, DUCHEN MR (1995). CHANGES IN INTRACELLULAR MAGNESIUM AND ATP-REGULATED K+ CHANNEL ACTIVITY WITH CHANGING METABOLIC STATE IN ISOLATED RAT CARDIOMYOCYTES. J PHYSIOL-LONDON, 483P, P9 - P10.
    • Smith PA, Duchen MR, Ashcroft FM (1995). A fluorimetric and amperometric study of calcium and secretion in isolated mouse pancreatic beta-cells.. Pflugers Arch, 430(5), 808 - 818.
    • Pearce RJ, Duchen MR (1995). Electrophysiological and metabolic effects of a convulsant barbiturate on dissociated mouse primary sensory neurons.. J Physiol, 483 ( Pt 2), 407 - 420.
    • TERAKAWA S, KUMAKURA K, DUCHEN MR (1995). SPATIOTEMPORAL ANALYSIS OF QUANTAL SECRETORY EVENTS FROM SINGLE BOVINE ADRENAL CHROMAFFIN CELLS IN CULTURE. J PHYSIOL-LONDON, 487P, P59 - P60.
    • MOJET MH, MILLS E, DUCHEN MR (1995). CHANGES IN MITOCHONDRIAL-FUNCTION, [CA2+](I) AND CATECHOLAMINE SECRETION IN RESPONSE TO HYPOXIA IN CHROMAFFIN CELLS DISSOCIATED FROM THE NEWBORN RAT ADRENAL. J PHYSIOL-LONDON, 487P, P59 - P59.
    • LEYSSENS A, RASTOGHI R, CRASKE M, CROMPTON M, DUCHEN MR (1995). TRANSIENT DEPOLARIZATIONS OF MITOCHONDRIA LOCALIZED TO DISCRETE AREAS OF SINGLE-RAT CARDIOMYOCYTES CAUSED BY FREE-RADICALS AND LOCAL CALCIUM-RELEASE - A MODEL FOR FREE RADICAL-INDUCED CELL INJURY. J PHYSIOL-LONDON, 487P, P123 - P124.

    1994

    • SMITH P, DUCHEN M, ASHCROFT FM (1994). VOLTAMMETRIC MONITORING OF 5-HT SECRETION FROM ISOLATED MOUSE PANCREATIC BETA-CELLS. J PHYSIOL-LONDON, 475P, P157 - P157.
    • LEYSSENS A, DUCHEN MR (1994). CHANGES IN INTRACELLULAR FREE MAGNESIUM WITH ATP DEPLETION IN SINGLE ISOLATED RAT CARDIOMYOCYTES. J PHYSIOL-LONDON, 480P, P90 - P90.
    • DUCHEN MR, PEUCHEN S, LEYSSENS A, NOWICKY AV, CLARK JB (1994). IMAGING MITOCHONDRIAL-FUNCTION IN SINGLE ISOLATED MAMMALIAN-CELLS. J PHYSIOL-LONDON, 475P, P7 - P8.
    • PEUCHEN S, CLARK JB, DUCHEN MR (1994). CHARACTERIZATION OF [CA2+](I) TRANSIENTS INDUCED BY NUCLEOTIDE RECEPTOR ACTIVATION IN ASTROCYTES CULTURED FROM THE FOREBRAIN OF THE ADULT-RAT. J PHYSIOL-LONDON, 475P, P106 - P106.
    • DUCHEN MR, NOWICKY AV, LEYSSENS A (1994). SIMULTANEOUS MEASUREMENTS OF MITOCHONDRIAL POTENTIAL AND NAD(P)H AUTOFLUORESCENCE FROM SINGLE ISOLATED MAMMALIAN-CELLS. J PHYSIOL-LONDON, 476P, P2 - P3.
    • NOWICKY AV, DUCHEN MR (1994). RELATIONSHIP BETWEEN MITOCHONDRIAL POTENTIAL AND INTRACELLULAR CALCIUM IN DISSOCIATED RAT HIPPOCAMPAL-NEURONS. J PHYSIOL-LONDON, 475P, P148 - P148.
    • Pearce RJ, Duchen MR (1994). Differential expression of membrane currents in dissociated mouse primary sensory neurons.. Neuroscience, 63(4), 1041 - 1056.

    1993

    • DUCHEN MR, CROMPTON M, PEUCHEN S, NOWICKY AV (1993). THE USE OF A CARBOCYANINE DYE, JC-1, TO MONITOR CHANGES OF MITOCHONDRIAL POTENTIAL IN ISOLATED MAMMALIAN-CELLS. J PHYSIOL-LONDON, 473, P7 - P7.
    • DUCHEN MR (1993). VOLTAMMETRIC DETECTION OF QUANTAL SECRETORY EVENTS FROM ISOLATED RAT PERITONEAL MAST-CELLS. J PHYSIOL-LONDON, 467, P2 - P2.
    • PEUCHEN S, CLARK JB, DUCHEN MR (1993). CHANGES IN [CA2+](I) IN RESPONSE TO ATP IN ASTROCYTES CULTURED FROM THE FOREBRAIN OF THE ADULT-RAT. J PHYSIOL-LONDON, 473, P42 - P42.
    • NOWICKY AV, PEUCHEN S, CLARK JB, DUCHEN MR (1993). SIMULTANEOUS MEASUREMENTS OF INTRACELLULAR CALCIUM AND MITOCHONDRIAL POTENTIAL IN ISOLATED MAMMALIAN-CELLS. J PHYSIOL-LONDON, 473, P10 - P10.
    • Duchen MR, McGuinness O, Brown LA, Crompton M (1993). On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury.. Cardiovasc Res, 27(10), 1790 - 1794.
    • PEUCHEN S, DUCHEN MR, CLARK JB (1993). MODULATION OF INTRACELLULAR CALCIUM IN CULTURED ADULT MAMMALIAN ASTROCYTES. J NEUROCHEM, 61, S44 - S44.
    • DUCHEN MR, SMITH PA, ASHCROFT FM (1993). SUBSTRATE-DEPENDENT CHANGES IN MITOCHONDRIAL-FUNCTION, [CA-2+]I AND KATP CHANNELS IN MOUSE PANCREATIC BETA-CELLS INVITRO. J PHYSIOL-LONDON, 459, P266 - P266.
    • Duchen MR, Smith PA, Ashcroft FM (1993). Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells.. Biochem J, 294 ( Pt 1), 35 - 42.
    • DUCHEN MR, PEUCHEN S, NOWICKY A (1993). CHANGES IN MITOCHONDRIAL-FUNCTION IN RESPONSE TO CHANGES IN CYTOSOLIC CA-2+ CONCENTRATION.

    1992

    • Duchen MR, Biscoe TJ (1992). Relative mitochondrial membrane potential and [Ca2+]i in type I cells isolated from the rabbit carotid body.. J Physiol, 450, 33 - 61.
    • PEARCE RJ, DUCHEN MR (1992). ACTIONS OF THE CONVULSANT BARBITURATE 5-(2-CYCLOHEXYLIDINE-ETHYL)-5-ETHYL BARBITURIC-ACID (CHEB) ON DISSOCIATED MOUSE SENSORY NEURONS. J PHYSIOL-LONDON, 446, P136 - P136.
    • Duchen MR (1992). Ca(2+)-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons.. Biochem J, 283 ( Pt 1), 41 - 50.
    • Duchen MR, Biscoe TJ (1992). Mitochondrial function in type I cells isolated from rabbit arterial chemoreceptors.. J Physiol, 450, 13 - 31.

    1991

    • Tatham PE, Duchen MR, Millar J (1991). Monitoring exocytosis from single mast cells by fast voltammetry.. Pflugers Arch, 419(3-4), 409 - 414.
    • DUCHEN MR (1991). CALCIUM-INDUCED CHANGES IN MITOCHONDRIAL-FUNCTION IN SINGLE DISSOCIATED MOUSE NEURONS. J PHYSIOL-LONDON, 438, P206 - P206.
    • FARQUHARSON D, DUCHEN MR, PEARCE RJ, BISCOE TJ (1991). APPARATUS FOR SIMULTANEOUS FLASH-PHOTOLYSIS AND MICROFLUORIMETRY. J PHYSIOL-LONDON, 438, P142 - P142.

    1990

    • Duchen MR, Valdeolmillos M, O'Neill SC, Eisner DA (1990). Effects of metabolic blockade on the regulation of intracellular calcium in dissociated mouse sensory neurones.. J Physiol, 424, 411 - 426.
    • Duchen MR (1990). Effects of metabolic inhibition on the membrane properties of isolated mouse primary sensory neurones.. J Physiol, 424, 387 - 409.
    • Biscoe TJ, Duchen MR (1990). Responses of type I cells dissociated from the rabbit carotid body to hypoxia.. J Physiol, 428, 39 - 59.
    • Biscoe TJ, Duchen MR (1990). Cellular basis of transduction in carotid chemoreceptors.. Am J Physiol, 258(6 Pt 1), L271 - L278.
    • DUCHEN MR, BISCOE TJ, VALDEOLMILLOS M (1990). BIOPHYSICAL STUDIES OF CELLS FROM THE CAROTID-BODY OF THE RABBIT.
    • PEARCE RJ, DUCHEN MR (1990). DIFFERENTIAL EXPRESSION OF MEMBRANE CURRENTS IN ISOLATED MOUSE PRIMARY SENSORY NEURONS. J PHYSIOL-LONDON, 425, P70 - P70.
    • DUCHEN MR, BISCOE TJ (1990). CHANGES IN MITOCHONDRIAL-MEMBRANE POTENTIAL AND [CA-2+]I WITH HYPOXIA IN TYPE-I CELLS ISOLATED FROM THE RABBIT CAROTID-BODY. J PHYSIOL-LONDON, 426, P65 - P65.
    • DUCHEN MR, MILLAR J, BISCOE TJ (1990). VOLTAMMETRIC MEASUREMENT OF CATECHOLAMINE RELEASE FROM ISOLATED RAT CHROMAFFIN CELLS. J PHYSIOL-LONDON, 426, P5 - P5.
    • DUCHEN MR, PEARCE RJ, BISCOE TJ (1990). USE OF MICROFLUORIMETRY TO MONITOR MITOCHONDRIAL-MEMBRANE POTENTIAL IN SINGLE DISSOCIATED MAMMALIAN-CELLS. J PHYSIOL-LONDON, 426, P2 - P2.
    • BISCOE TJ, DUCHEN MR (1990). MONITORING PO2 BY THE CAROTID CHEMORECEPTOR. NEWS PHYSIOL SCI, 5, 229 - 233.

    1989

    • Biscoe TJ, Duchen MR, Eisner DA, O'Neill SC, Valdeolmillos M (1989). Measurements of intracellular Ca2+ in dissociated type I cells of the rabbit carotid body.. J Physiol, 416, 421 - 434.
    • Biscoe TJ, Duchen MR (1989). Electrophysiological responses of dissociated type I cells of the rabbit carotid body to cyanide.. J Physiol, 413, 447 - 468.
    • DUCHEN MR, PEARCE RJ (1989). A PREPARATION OF NEURONS FRESHLY DISSOCIATED FROM MOUSE DORSAL-ROOT GANGLIA FOR ELECTROPHYSIOLOGICAL STUDY. J PHYSIOL-LONDON, 415, P6 - P6.
    • BISCOE TJ, DUCHEN MR, FRY JP, RICKETS C (1989). PURIFICATION AND ACTIONS OF ENDOGENOUS BENZODIAZEPINE-LIKE IMMUNOREACTIVITY ISOLATED FROM THE BRAIN OF THE MOUSE. J PHYSIOL-LONDON, 415, P50 - P50.
    • BISCOE TJ, DUCHEN MR (1989). HYPOXIA RAISES INTRACELLULAR CALCIUM IN TYPE-I CELLS ISOLATED FROM THE RABBIT CAROTID-BODY. J PHYSIOL-LONDON, 418, P128 - P128.
    • DUCHEN MR (1989). GABAA RESPONSES OF DISSOCIATED MOUSE NEURONS ARE ATTENUATED BY METABOLIC BLOCKADE. J PHYSIOL-LONDON, 415, P48 - P48.

    1988

    • Duchen MR, Caddy KW, Kirby GC, Patterson DL, Ponte J, Biscoe TJ (1988). Biophysical studies of the cellular elements of the rabbit carotid body.. Neuroscience, 26(1), 291 - 311.
    • DUCHEN MR, SOMJEN GG (1988). EFFECTS OF CYANIDE AND LOW GLUCOSE ON THE MEMBRANE CURRENTS OF DISSOCIATED MOUSE PRIMARY SENSORY NEURONS. J PHYSIOL-LONDON, 401, P61 - P61.
    • BISCOE TJ, DUCHEN MR, EISNER DA, ONEILL SC, VALDEOLMILLOS M (1988). CYANIDE INCREASES [CA-2+]I IN ISOLATED TYPE-I CELLS FROM THE RABBIT CAROTID-BODY. J PHYSIOL-LONDON, 396, P99 - P99.
    • BISCOE TJ, DUCHEN MR, KIRBY GC, PATTERSON DL, PONTE J (1988). VOLTAGE-CLAMP STUDY OF THE EFFECTS OF CYANIDE ON DISSOCIATED TYPE-I CELLS OF THE RABBIT CAROTID-BODY. J PHYSIOL-LONDON, 396, P178 - P178.
    • BISCOE TJ, DUCHEN MR, EISNER DA, ONEILL SC, VALDEOLMILLOS M (1988). THE EFFECTS OF GLUCOSE REMOVAL AND CYANIDE ON INTRACELLULAR CA-2+ IN ISOLATED, SINGLE-MOUSE DORSAL-ROOT GANGLION-CELLS. J PHYSIOL-LONDON, 401, P60 - P60.

    1987

    • Yu YB, Duchen MR, Biscoe TJ (1987). Primary afferent terminal excitability in the normal and spastic mutant mouse spinal cord.. Eur J Pharmacol, 141(3), 371 - 382.
    • BISCOE TJ, DUCHEN MR, PATTERSON DL (1987). DUAL ACTIONS OF GLYCINE ON DISSOCIATED MOUSE SPINAL NEURONS. J PHYSIOL-LONDON, 382, P133 - P133.
    • BISCOE TJ, CADDY KWT, DUCHEN MR, KIRBY GC, PATTERSON DL, PONTE J (1987). PREPARATION AND IDENTIFICATION OF FRESHLY DISSOCIATED CELLS FROM THE RABBIT CAROTID-BODY FOR ELECTROPHYSIOLOGICAL STUDY. J PHYSIOL-LONDON, 392, P11 - P11.
    • BISCOE TJ, DUCHEN MR, KIRBY GC, PATTERSON DL, PONTE J (1987). ELECTROPHYSIOLOGICAL CHARACTERIZATION OF FRESHLY DISSOCIATED TYPE-I CELLS FROM THE RABBIT CAROTID-BODY. J PHYSIOL-LONDON, 392, P36 - P36.

    1986

    • Biscoe TJ, Duchen MR (1986). Synaptic physiology of spinal motoneurones of normal and spastic mice: an in vitro study.. J Physiol, 379, 275 - 292.
    • Duchen MR (1986). Excitation of mouse motoneurones by GABA-mediated primary afferent depolarization.. Brain Res, 379(1), 182 - 187.
    • BISCOE TJ, DUCHEN MR, PATTERSON L (1986). VOLTAGE-CLAMP STUDY OF ACUTELY DISSOCIATED MOUSE SPINAL NEURONS. J PHYSIOL-LONDON, 377, P10 - P10.

    1985

    • Biscoe TJ, Duchen MR (1985). An intracellular study of dentate, CA1 and CA3 neurones in the mouse hippocampal slice.. Q J Exp Physiol, 70(2), 189 - 202.
    • Biscoe TJ, Duchen MR (1985). Actions and interactions of GABA and benzodiazepines in the mouse hippocampal slice.. Q J Exp Physiol, 70(3), 313 - 328.
    • DUCHEN MR (1985). EXCITATION OF MOTONEURONES BY GABA-MEDIATED PRIMARY AFFERENT DEPOLARIZATION IN THE MOUSE SPINAL-CORD INVITRO. J PHYSIOL-LONDON, 364(JUL), P45 - P45.
    • BISCOE TJ, DUCHEN MR, WILSON MGA (1985). USE OF THE RML MICROCOMPUTER 380Z FOR ONLINE TESTING OF PRIMARY AFFERENT TERMINAL EXCITABILITY IN THE MOUSE SPINAL-CORD INVITRO. J PHYSIOL-LONDON, 365(AUG), P2 - P2.
    • Duchen MR, Burton NR, Biscoe TJ (1985). An intracellular study of the interactions of N-methyl-DL-aspartate with ketamine in the mouse hippocampal slice.. Brain Res, 342(1), 149 - 153.
    • Biscoe TJ, Duchen MR (1985). The anion selectivity of GABA-mediated post-synaptic potentials in mouse hippocampal cells.. Q J Exp Physiol, 70(3), 305 - 312.

    1983

    • BISCOE TJ, DUCHEN MR, PASCOE JE (1983). USE OF THE RML-380Z MICROCOMPUTER FOR ONLINE MEASUREMENT OF INPUT RESISTANCE OF CELLS IN THE MOUSE HIPPOCAMPAL SLICE. J PHYSIOL-LONDON, 341(AUG), P2 - P3.
    • BISCOE TJ, DUCHEN MR, PASCOE JE (1983). GABA BENZODIAZEPINE INTERACTIONS IN THE MOUSE HIPPOCAMPAL SLICE. J PHYSIOL-LONDON, 341(AUG), P8 - P9.

    1982

    • BISCOE TJ, CRUNELLI V, DUCHEN MR, FORDA S (1982). THE MOUSE HIPPOCAMPAL SLICE - INTRACELLULAR-RECORDINGS FROM PYRAMIDAL NEURONS AND DENTATE GRANULE CELLS. J PHYSIOL-LONDON, 328(JUL), P5 - P5.

    1980

    • Duchen MR, McNeilly AS (1980). Hyperprolactinaemia and long-term lactational amenorrhoea.. Clin Endocrinol (Oxf), 12(6), 621 - 627.