Prof Andres Ruiz-Linares

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Personal Profile

Name: Andres Ruiz-Linares Email: a.ruizlin@ucl.ac.uk
Title: Prof Tel: 020 3108 4003
Department: Genetics, Evolution & Environment Fax: 020 7679 7193
Position: Professor of Human Genetics Address: Department of Genetics, Evolution and Environment, Gower Street , London, WC1E 6BT
Research Domain: Basic Life Sciences, Genetics (Frontier Disciplines), Global Health, Heritage, History & Cultures, Intercultural Interaction, Migration, Neuroscience, Origins, Populations & Lifelong Health Web Page: Personal Web Page

Profile

Research Description

We have been exploring patterns of diversity in Native Americans using autosomal, sex- chromosome and mtDNA markers in order to examine the process of initial settlement of the Americas, the pattern of population dispersal in the continent and the relationship of genetic data to other sources of historical information (1,2,4). We are also interested in probing the genetic history of recently established Latin American populations seeking to characterize the process of European, Native American and African admixture in the region (3,5).

1 Yang et al. (2010) Contrasting patterns of nuclear and mtDNA diversity in Native American populations. Annals of Human Genetics

2- Ray et al. (2010) A statistical evaluation of models for the initial settlement of the American continent emphasizes the importance of gene flow with Asia. Mol Biol Evol. 27:337-45.

3- Wang et al. (2008) Geographic patterns of genome admixture in Latin American Mestizos PLoS Genet 4: e1000037

4- Wang et al. (2007) Genetic variation and population structure in Native Americans. PLoS Genetics 3:185.

5- Bedoya (2006) Admixture dynamics in Hispanics: a shift in the nuclear genetic ancestry of a South American population isolate. Proc Natl.Acad.Sci.U.S.A 103, 7234-7239.

 

We have also been interested in exploiting properties of certain Latin American populations that could facilitate gene identifiation: geographic isolation, admixture and rapid demographic growth. This has led us to apply linkage and association approaches to both Mendelian (1) and complex disorders (3,5). We have been interested in the development and application of mapping genetic methods tailored to recently admixed populations (2,4). We recently initiated a large study aimed at identifying genes underlying the differentiated physical appearance of Native Americans and Europeans using a combined association/admixture mapping approach in admixed Latin American populations.

1- Kremeyer et al (2010) A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Neuron. 66:671-80.

2- Florez et al (2009) Strong association of socioeconomic status with genetic ancestry in Latinos: implications for admixture studies of type 2 diabetes. Diabetologia. 52: 1528-1536.

3- Jasinska et al. (2009) Narrow and Highly Significant Linkage Signal for Severe Bipolar Disorder in the Chromosome 5q33 Region in Latin American Pedigrees. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150:998-1006.

4- Price (2007) A genomewide admixture map for latino populations. Am.J.Hum.Genet. 80, 1024-1036.

5- Herzberg . (2006) Convergent linkage evidence from two Latin-American population isolates supports the presence of a susceptibility locus for bipolar disorder in 5q31-34. Hum.Mol.Genet. 15, 3146-3153.

 

 


Research Activities

Use of genetic variation in the study of demographic history

Evolutionary Genetics

Genetic Epidemiology

Genetic basis of neurological disease

Genetic polymorphism

Genetic studies of neurological disease

Genetics

Genetics of brain disorders

Human genetic variation affecting function

Molecular genetics

Molecular genetics of childhood inherited disorder

genetics of face and object perception

population genetics

Education Description

I co-organize UCL's MSc on the Genetics of Human Disease and organize two half-unit courses taken by undergraduate, intercalated, M.Sci and M.Sc. students: "Advanced Human Genetics 1: single gene disorders" in the first term and "Advanced Human Genetics 2: complex disorders." in the second term.

UCL Collaborators

Prof John Hardy; Prof Dallas Swallow; Prof Jim Mallet; Dr Nikolas Maniatis; Prof Ziheng Yang; Prof Michelle Saunders; Prof Steve Jones; Dr Andrew Mcquillin; Prof Robert Kleta; Dr Eddie Chung; Prof Francesco Muntoni; Prof David Joseph Balding

External Collaborators

Publications

    2014

    • Fears SC, Service SK, Kremeyer B, Araya C, Araya X, Bejarano J, Ramirez M, Castrillón G, Gomez-Franco J, Lopez MC, Montoya G, Montoya P, Aldana I, Teshiba TM, Abaryan Z, Al-Sharif NB, Ericson M, Jalbrzikowski M, Luykx JJ, Navarro L, Tishler TA, Altshuler L, Bartzokis G, Escobar J, Glahn DC, Ospina-Duque J, Risch N, Ruiz-Linares A, Thompson PM, Cantor RM, Lopez-Jaramillo C, Macaya G, Molina J, Reus VI, Sabatti C, Freimer NB, Bearden CE (2014). Multisystem Component Phenotypes of Bipolar Disorder for Genetic Investigations of Extended Pedigrees.. JAMA Psychiatry, , - . doi:10.1001/jamapsychiatry.2013.4100

    2013

    • Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Cardona Silgado JC, Cath DC, Cavallini MC, Chavira DA, Chouinard S, Conti DV, Cook EH, Coric V, Cullen BA, Deforce D, Delorme R, Dion Y, Edlund CK, Egberts K, Falkai P, Fernandez TV, Gallagher PJ, Garrido H, Geller D, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Haddad S, Heiman GA, Hemmings SM, Hounie AG, Illmann C, Jankovic J, Jenike MA, Kennedy JL, King RA, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Macciardi F, McCracken JT, McGrath LM, Mesa Restrepo SC, Moessner R, Morgan J, Muller H, Murphy DL, Naarden AL, Ochoa WC, Ophoff RA, Osiecki L, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner TJ, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosàrio MC, Rosenberg D, Rouleau GA, Ruhrmann S, Ruiz-Linares A, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Valencia Duarte AV, Vallada H, Van Nieuwerburgh F, Veenstra-Vanderweele J, Walitza S, Wang Y, Wendland JR, Westenberg HG, Shugart YY, Miguel EC, McMahon W, Wagner M, Nicolini H, Posthuma D, Hanna GL, Heutink P, Denys D, Arnold PD, Oostra BA, Nestadt G, Freimer NB, Pauls DL, Wray NR, Stewart SE, Mathews CA, Knowles JA, Cox NJ, Scharf JM (2013). Partitioning the heritability of tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.. PLoS Genet, 9(10), e1003864 - . doi:10.1371/journal.pgen.1003864
    • Fernandes-Lima ZS, Paixão-Côrtes VR, de Andrade AK, Fernandes AS, Coronado BN, Monte Filho HP, Santos MJ, de Omena Filho RL, Biondi FC, Ruiz-Linares A, Ramallo V, Hünemeier T, Schuler-Faccini L, Monlleó IL (2013). Ocular And Craniofacial Phenotypes In A Large Brazilian Family With Congenital Aniridia.. Clin Genet, , - . doi:10.1111/cge.12329
    • Moreau C, Lefebvre JF, Jomphe M, Bhérer C, Ruiz-Linares A, Vézina H, Roy-Gagnon MH, Labuda D (2013). Native american admixture in the quebec founder population.. PLoS One, 8(6), e65507 - . doi:10.1371/journal.pone.0065507
    • Gravel S, Zakharia F, Moreno-Estrada A, Byrnes JK, Muzzio M, Rodriguez-Flores JL, Kenny EE, Gignoux CR, Maples BK, Guiblet W, Dutil J, Via M, Sandoval K, Bedoya G, 1000 Genomes Project , Oleksyk TK, Ruiz-Linares A, Burchard EG, Martinez-Cruzado JC, Bustamante CD (2013). Reconstructing native american migrations from whole-genome and whole-exome data.. PLoS Genet, 9(12), e1004023 - . doi:10.1371/journal.pgen.1004023
    • Caro-Gomez MA, Carrizosa J, Moreno JT, Cabrera D, Bedoya G, Ruiz-Linares A, Franco A, Gomez-Castillo C, Cornejo W, Pineda-Trujillo N (2013). Segregation of a haplotype encompassing FEB1 with genetic epilepsy with febrile seizures plus in a Colombian family.. Epileptic Disord, , - . doi:10.1684/epd.2013.0570
    • Nag A, Bochukova EG, Kremeyer B, Campbell DD, Muller H, Valencia-Duarte AV, Cardona J, Rivas IC, Mesa SC, Cuartas M, Garcia J, Bedoya G, Cornejo W, Herrera LD, Romero R, Fournier E, Reus VI, Lowe TL, Farooqi IS, Tourette Syndrome Association International Consortium for Genetics , Mathews CA, McGrath LM, Yu D, Cook E, Wang K, Scharf JM, Pauls DL, Freimer NB, Plagnol V, Ruiz-Linares A (2013). CNV analysis in Tourette syndrome implicates large genomic rearrangements in COL8A1 and NRXN1.. PLoS One, 8(3), e59061 - . doi:10.1371/journal.pone.0059061
    • Gómez-Valdés JA, Hünemeier T, Contini V, Acuña-Alonzo V, Macin G, Ballesteros-Romero M, Corral P, Ruiz-Linares A, Sánchez-Mejorada G, Canizales-Quinteros S, Martínez-Abadías N, Salzano FM, González-José R, Bortolini MC (2013). Fibroblast growth factor receptor 1 (FGFR1) variants and craniofacial variation in Amerindians and related populations.. Am J Hum Biol, 25(1), 12 - 19. doi:10.1002/ajhb.22331
    • Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrio GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, Hardy J, Strengman E, Ophoff RA, Wagner M, Moessner R, Mirel DB, Posthuma D, Sabatti C, Eskin E, Conti DV, Knowles JA, Ruiz-Linares A, Rouleau GA, Purcell S, Heutink P, Oostra BA, McMahon WM, Freimer NB, Cox NJ, Pauls DL, Expression NAB, Database UKHBE (2013). Genome-wide association study of Tourette's syndrome. MOLECULAR PSYCHIATRY, 18(6), 721 - 728. doi:10.1038/mp.2012.69

    2012

    • Hünemeier T, Amorim CE, Azevedo S, Contini V, Acuña-Alonzo V, Rothhammer F, Dugoujon JM, Mazières S, Barrantes R, Villarreal-Molina MT, Paixão-Côrtes VR, Salzano FM, Canizales-Quinteros S, Ruiz-Linares A, Bortolini MC (2012). Evolutionary responses to a constructed niche: ancient Mesoamericans as a model of gene-culture coevolution.. PLoS One, 7(6), e38862 - . doi:10.1371/journal.pone.0038862
    • Donnelly P, McVean GA, Lunter G, Marchini JL, Myers S, Gupta-Hinch A, Iqbal Z, Mathieson I, Rimmer A, Xifara DK, Kerasidou A, Churchhouse C, Delaneau O, Altshuler DM, Gabriel SB, Lander ES, Gupta N, Daly MJ, Depristo MA, Banks E, Bhatia G, Carneiro MO, Del Angel G, Genovese G, Handsaker RE, Hartl C, McCarroll SA, Nemesh JC, Poplin RE, Schaffner SF, Shakir K, Sabeti PC, Grossman SR, Tabrizi S, Tariyal R, Li H, Reich D, Durbin RM, Hurles ME, Balasubramaniam S, Burton J, Danecek P, Keane TM, Kolb-Kokocinski A, McCarthy S, Stalker J, Quail M, Tyler-Smith C, Ayub Q, Chen Y, Coffey AJ, Colonna V, Huang N, Jostins L, Scally A, Walter K, Xue Y, Zhang Y, Blackburne B, Lindsay SJ, Ning Z, Frankish A, Harrow J, Abecasis GR, Min Kang H, Anderson P, Blackwell T, Busonero F, Fuchsberger C, Jun G, Maschio A, Porcu E, Sidore C, Tan A, Kate Trost M, Bentley DR, Grocock R, Humphray S, James T, Kingsbury Z, Bauer M, Keira Cheetham R, Cox T, Eberle M, Kahn S, Murray L, Peden J, Shaw R, Chakravarti A, Clark AG, Keinan A, Rodriguez-Flores JL, De La Vega FM, Degenhardt J, Eichler EE, Flicek P, Clarke L, Leinonen R, Smith RE, Zheng-Bradley X, Beal K, Cunningham F, Herrero J, McLaren WM, Ritchie GRS, Barker J, Kelman G, Kulesha E, Radhakrishnan R, Roa A, Smirnov D, Streeter I, Toneva I, Vaughan B, Gibbs RA, Dinh H, Kovar C, Lee S, Lewis L, Muzny D, Reid J, Wang M, Yu F, Bainbridge M, Challis D, Evani US, Lu J, Nagaswamy U, Sabo A, Wang Y, Yu J, Fowler G, Hale W, Kalra D, Green ED, Knoppers BM, Korbel JO, Rausch T, Stütz AM, Lee C, Griffin L, Hsieh C-H, Mills RE, Shi X, Von Grotthuss M, Zhang C, Lehrach H, Sudbrak R, Amstislavskiy VS, Lienhard M, Mertes F, Sultan M, Timmermann B, Yaspo M-L, Herwig R, Mardis ER, Wilson RK, Fulton L, Fulton R, Weinstock GM, Chinwalla A, Ding L, Dooling D, Koboldt DC, McLellan MD, Wallis JW, Wendl MC, Zhang Q, Marth GT, Garrison EP, Kural D, Lee W-P, Fung Leong W, Ward AN, Wu J, Zhang M, Nickerson DA, Alkan C, Hormozdiari F, Ko A, Sudmant PH, Schmidt JP, Davies CJ, Gollub J, Webster T, Wong B, Zhan Y, Sherry ST, Xiao C, Church D, Ananiev V, Belaia Z, Beloslyudtsev D, Bouk N, Chen C, Cohen R, Cook C, Garner J, Hefferon T, Kimelman M, Liu C, Lopez J, Meric P, Ostapchuk Y, Phan L, Ponomarov S, Schneider V, Shekhtman E, Sirotkin K, Slotta D, Zhang H, Wang J, Fang X, Guo X, Jian M, Jiang H, Jin X, Li G, Li J, Li Y, Li Z, Liu X, Lu Y, Ma X, Su Z, Tai S, Tang M, Wang B, Wang G, Wu H, Wu R, Yin Y, Zhang W, Zhao J, Zhao M, Zheng X, Zhou Y, Coin LJM, Fang L, Li Q, Lin H, Liu B, Luo R, Qin N, Shao H, Xie Y, Ye C, Yu C, Zhang F, Zheng H, Zhu H, Cai H, Cao H, Su Y, Tian Z, Yang H, Yang L, Zhu J, Ming CZ, Albrecht MW, Borodina TA, Auton A, Yoon SC, Lihm J, Makarov V, Jin H, Kim W, Cheol Kim K, Gravel S, Gottipati S, Jones D, Cooper DN, Ball EV, Stenson PD, Barnes B, Ye K, Batzer MA, Konkel MK, Walker JA, MacArthur DG, Lek M, Shriver MD, Bustamante CD, Kenny EE, Kidd JM, Maples BK, Moreno-Estrada A, Zakharia F, Henn B, Sandoval K, Lacroute P, Byrnes JK, Halperin E, Baran Y, Craig DW, Christoforides A, Izatt T, Kurdoglu AA, Sinari SA, Homer N, Squire K, Sebat J, Bafna V, Burchard EG, Hernandez RD, Gignoux CR, Haussler D, Katzman SJ, James Kent W, Howie B, Ruiz-Linares A, Dermitzakis ET, Lappalainen T, Devine SE, Maroo A, Tallon LJ, Rosenfeld JA, Michelson LP, Angius A, Cucca F, Sanna S, Bigham A, Jones C, Reinier F, Lyons R, Schlessinger D, Awadalla P, Hodgkinson A, Oleksyk TK, Martinez-Cruzado JC, Fu Y, Xiong M, Jorde L, Witherspoon D, Xing J, Browning BL, Hajirasouliha I, Chen K, Albers CA, Gerstein MB, Abyzov A, Chen J, Habegger L, Harmanci AO, Jasmine Mu X, Sisu C, Balasubramanian S, Jin M, Khurana E, Mu XJ, Clarke D, Michaelson JJ, O'Sullivan C, Barnes KC, Beiswanger C, Gharani N, Toji LH, Kaye JS, Kent A, Mathias R, Ossorio PN, Parker M, Rotimi CN, Royal CD, Tishkoff S, Via M, Bodmer W, Bedoya G, Yang (2012). An integrated map of genetic variation from 1,092 human genomes. Nature, 491(7422), 56 - 65. doi:10.1038/nature11632
    • Scharf J, Yu D, Mathews C, Neale B, Stewart E, Fagerness J, Evans P, Gamazon E, Service S, Osiecki L, Illmann C, Cath D, King R, Dion Y, Sandor P, Barr C, Budman C, Lyon G, Grados M, Singer H, Jankovic J, Gilbert D, Hoekstra P, Heiman G, Tischfield J, State M, Robertson M, Kurlan R, Ophoff R, Gibbs JR, Cookson M, Hardy J, Singleton A, Ruiz-Linares A, Rouleau G, Heutink P, Oostra B, McMahon W, Freimer N, Cox N, Pauls D (2012). Genome-Wide Association Study of Gilles de la Tourette Syndrome.
    • Reich D, Patterson N, Campbell D, Tandon A, Mazieres S, Ray N, Parra MV, Rojas W, Duque C, Mesa N, Garc�a LF, Triana O, Blair S, Maestre A, Dib JC, Bravi CM, Bailliet G, Corach D, H�nemeier T, Bortolini MC, Salzano FM, Petzl-Erler ML, Acu�a-Alonzo V, Aguilar-Salinas C, Canizales-Quinteros S, Tusi�-Luna T, Riba L, Rodr�guez-Cruz M, Lopez-Alarc�n M, Coral-Vazquez R, Canto-Cetina T, Silva-Zolezzi I, Fernandez-Lopez JC, Contreras AV, Jimenez-Sanchez G, G�mez-V�zquez MJ, Molina J, Carracedo A, Salas A, Gallo C, Poletti G, Witonsky DB, Alkorta-Aranburu G, Sukernik RI, Osipova L, Fedorova SA, Vasquez R, Villena M, Moreau C, Barrantes R, Pauls D, Excoffier L, Bedoya G, Rothhammer F, Dugoujon JM, Larrouy G, Klitz W, Labuda D, Kidd J, Kidd K, Di Rienzo A, Freimer NB, Price AL, Ruiz-Linares A (2012). Reconstructing Native American population history. Nature, 488, 370 - 374. doi:10.1038/nature11258
    • Campbell DD, Parra MV, Duque C, Gallego N, Franco L, Tandon A, Hünemeier T, Bortolini C, Villegas A, Bedoya G, McCarthy MI, Price A, Reich D, Ruiz-Linares A (2012). Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population.. PLoS One, 7(4), e33570 - . doi:10.1371/journal.pone.0033570
    • Rojas W, Parra MV, Campo O, Caro MA, Lopera JG, Arias W, Duque C, Naranjo A, Garcia J, Vergara C, Lopera J, Hernandez E, Valencia A, Caicedo Y, Torres MM, Groot de Restrepo H, Cuartas M, Gutierrez J, Lopez S, Ruiz-Linares A, Bedoya G (2012). Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers (vol 143, pg 13, 2010). AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 147(1), 168 - 168. doi:10.1002/ajpa.21642
    • Pardo LM, Piras G, Asproni R, van der Gaag KJ, Gabbas A, Ruiz-Linares A, de Knijff P, Monne M, Rizzu P, Heutink P (2012). Dissecting the genetic make-up of North-East Sardinia using a large set of haploid and autosomal markers.. Eur J Hum Genet, 20(9), 956 - 964. doi:10.1038/ejhg.2012.22
    • Amorim CEG, Wang S, Ruiz-Linares A, Bortolini MC, Bonatto SL, Salzano FM (2012). X-chromosomal genetic diversity and linkage disequilibrium patterns in Native Americans and worldwide populations. AMERICAN JOURNAL OF HUMAN BIOLOGY, 24(2), 218 - 218.

    2011

    • Cuartas Arias JM, Palacio Acosta CA, Valencia JG, Montoya GJ, Arango Viana JC, Nieto OC, Flórez AF, Camarena Medellin BE, Montoya WR, Lopez Jaramillo CA, Achury JG, Fuentes CC, Berrio GB, Ruiz-Linares A (2011). Exploring epistasis in candidate genes for antisocial personality disorder.. Psychiatr Genet, 21(3), 115 - 124. doi:10.1097/YPG.0b013e3283437175
    • Amorim CE, Wang S, Marrero AR, Salzano FM, Ruiz-Linares A, Bortolini MC (2011). X-chromosomal genetic diversity and linkage disequilibrium patterns in Amerindians and non-Amerindian populations.. Am J Hum Biol, 23(3), 299 - 304. doi:10.1002/ajhb.21110

    2010

    • Wang S, Bedoya G, Labuda D, Ruiz-Linares A (2010). Brief communication: patterns of linkage disequilibrium and haplotype diversity at Xq13 in six Native American populations.. Am J Phys Anthropol, 142(3), 476 - 480. doi:10.1002/ajpa.21234
    • Hünemeier T, Ruiz-Linares A, Silveira A, Paixão-Côrtes VR, Salzano FM, Bortolini MC (2010). Brief communication: Population data support the adaptive nature of HACNS1 sapiens/neandertal-chimpanzee differences in a limb expression domain.. Am J Phys Anthropol, 143(3), 478 - 481. doi:10.1002/ajpa.21378
    • Ray N, Wegmann D, Fagundes NJ, Wang S, Ruiz-Linares A, Excoffier L (2010). A statistical evaluation of models for the initial settlement of the american continent emphasizes the importance of gene flow with Asia.. Mol Biol Evol, 27(2), 337 - 345. doi:10.1093/molbev/msp238
    • Herzberg I, Valencia-Duarte AV, Kay VA, White DJ, Müller H, Rivas IC, Mesa SC, Cuartas M, García J, Bedoya G, Cornejo W, Ruiz-Linares A, Kremeyer B (2010). Association of DRD2 variants and Gilles de la Tourette syndrome in a family-based sample from a South American population isolate.. Psychiatr Genet, 20(4), 179 - 183. doi:10.1097/YPG.0b013e32833a215a
    • Kremeyer B, Lopera F, Cox JJ, Momin A, Rugiero F, Marsh S, Woods CG, Jones NG, Paterson KJ, Fricker FR, Villegas A, Acosta N, Pineda-Trujillo NG, Ramírez JD, Zea J, Burley MW, Bedoya G, Bennett DL, Wood JN, Ruiz-Linares A (2010). A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome.. Neuron, 66(5), 671 - 680. doi:10.1016/j.neuron.2010.04.030
    • Yang NN, Mazières S, Bravi C, Ray N, Wang S, Burley MW, Bedoya G, Rojas W, Parra MV, Molina JA, Gallo C, Poletti G, Hill K, Hurtado AM, Petzl-Erler ML, Tsuneto LT, Klitz W, Barrantes R, Llop E, Rothhammer F, Labuda D, Salzano FM, Bortolini MC, Excoffier L, Dugoujon JM, Ruiz-Linares A (2010). Contrasting patterns of nuclear and mtDNA diversity in Native American populations.. Ann Hum Genet, 74(6), 525 - 538. doi:10.1111/j.1469-1809.2010.00608.x
    • Kremeyer B, García J, Müller H, Burley MW, Herzberg I, Parra MV, Duque C, Vega J, Montoya P, López MC, Bedoya G, Reus V, Palacio C, López C, Ospina-Duque J, Freimer NB, Ruiz-Linares A (2010). Genome-wide linkage scan of bipolar disorder in a Colombian population isolate replicates Loci on chromosomes 7p21-22, 1p31, 16p12 and 21q21-22 and identifies a novel locus on chromosome 12q.. Hum Hered, 70(4), 255 - 268. doi:10.1159/000320914
    • Rojas W, Parra MV, Campo O, Caro MA, Lopera JG, Arias W, Duque C, Naranjo A, García J, Vergara C, Lopera J, Hernandez E, Valencia A, Caicedo Y, Cuartas M, Gutiérrez J, López S, Ruiz-Linares A, Bedoya G (2010). Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers.. Am J Phys Anthropol, 143(1), 13 - 20. doi:10.1002/ajpa.21270

    2009

    • Bourgeois S, Yotova V, Wang S, Bourtoumieu S, Moreau C, Michalski R, Moisan JP, Hill K, Hurtado AM, Ruiz-Linares A, Labuda D (2009). X-chromosome lineages and the settlement of the Americas.. Am J Phys Anthropol, 140(3), 417 - 428. doi:10.1002/ajpa.21084
    • Jasinska AJ, Service S, Jawaheer D, DeYoung J, Levinson M, Zhang Z, Kremeyer B, Muller H, Aldana I, Garcia J, Restrepo G, Lopez C, Palacio C, Duque C, Parra M, Vega J, Ortiz D, Bedoya G, Mathews C, Davanzo P, Fournier E, Bejarano J, Ramirez M, Araya Ortiz C, Araya X, Molina J, Sabatti C, Reus V, Ospina J, Macaya G, Ruiz-Linares A, Freimer NB (2009). A narrow and highly significant linkage signal for severe bipolar disorder in the chromosome 5q33 region in Latin American pedigrees.. Am J Med Genet B Neuropsychiatr Genet, 150B(7), 998 - 1006. doi:10.1002/ajmg.b.30956
    • Florez JC, Price AL, Campbell D, Riba L, Parra MV, Yu F, Duque C, Saxena R, Gallego N, Tello-Ruiz M, Franco L, Rodríguez-Torres M, Villegas A, Bedoya G, Aguilar-Salinas CA, Tusié-Luna MT, Ruiz-Linares A, Reich D (2009). Strong association of socioeconomic status with genetic ancestry in Latinos: implications for admixture studies of type 2 diabetes.. Diabetologia, 52(8), 1528 - 1536. doi:10.1007/s00125-009-1412-x
    • Vergara C, Caraballo L, Mercado D, Jimenez S, Rojas W, Rafaels N, Hand T, Campbell M, Tsai YJ, Gao L, Duque C, Lopez S, Bedoya G, Ruiz-Linares A, Barnes KC (2009). African ancestry is associated with risk of asthma and high total serum IgE in a population from the Caribbean Coast of Colombia.. Hum Genet, 125(5-6), 565 - 579. doi:10.1007/s00439-009-0649-2
    • Kremeyer B, García J, Kymäläinen H, Wratten N, Restrepo G, Palacio C, Miranda AL, López C, Restrepo M, Bedoya G, Brzustowicz LM, Ospina-Duque J, Arbeláez MP, Ruiz-Linares A (2009). Evidence for a role of the NOS1AP (CAPON) gene in schizophrenia and its clinical dimensions: an association study in a South American population isolate.. Hum Hered, 67(3), 163 - 173. doi:10.1159/000181154

    2008

    • Price AL, Butler J, Patterson N, Capelli C, Pascali VL, Scarnicci F, Ruiz-Linares A, Groop L, Saetta AA, Korkolopoulou P, Seligsohn U, Waliszewska A, Schirmer C, Ardlie K, Ramos A, Nemesh J, Arbeitman L, Goldstein DB, Reich D, Hirschhorn JN (2008). Discerning the ancestry of European Americans in genetic association studies.. PLoS Genet, 4(1), e236 - . doi:10.1371/journal.pgen.0030236
    • Wang S, Ray N, Rojas W, Parra MV, Bedoya G, Gallo C, Poletti G, Mazzotti G, Hill K, Hurtado AM, Camrena B, Nicolini H, Klitz W, Barrantes R, Molina JA, Freimer NB, Bortolini MC, Salzano FM, Petzl-Erler ML, Tsuneto LT, Dipierri JE, Alfaro EL, Bailliet G, Bianchi NO, Llop E, Rothhammer F, Excoffier L, Ruiz-Linares A (2008). Geographic patterns of genome admixture in Latin American Mestizos.. PLoS Genet, 4(3), e1000037 - . doi:10.1371/journal.pgen.1000037
    • Nikali K, Vanegas JJ, Burley MW, Martinez J, Lopez LM, Bedoya G, Wrong OM, Povey S, Unwin RJ, Ruiz-Linares A (2008). Extensive founder effect for distal renal tubular acidosis (dRTA) with sensorineural deafness in an isolated South American population.. Am J Med Genet A, 146A(20), 2709 - 2712. doi:10.1002/ajmg.a.32495

    2007

    • Wang S, Lewis CM, Jakobsson M, Ramachandran S, Ray N, Bedoya G, Rojas W, Parra MV, Molina JA, Gallo C, Mazzotti G, Poletti G, Hill K, Hurtado AM, Labuda D, Klitz W, Barrantes R, Bortolini MC, Salzano FM, Petzl-Erler ML, Tsuneto LT, Llop E, Rothhammer F, Excoffier L, Feldman MW, Rosenberg NA, Ruiz-Linares A (2007). Genetic variation and population structure in native Americans.. PLoS Genet, 3(11), e185 - . doi:10.1371/journal.pgen.0030185
    • Price AL, Patterson N, Yu F, Cox DR, Waliszewska A, McDonald GJ, Tandon A, Schirmer C, Neubauer J, Bedoya G, Duque C, Villegas A, Bortolini MC, Salzano FM, Gallo C, Mazzotti G, Tello-Ruiz M, Riba L, Aguilar-Salinas CA, Canizales-Quinteros S, Menjivar M, Klitz W, Henderson B, Haiman CA, Winkler C, Tusie-Luna T, Ruiz-Linares A, Reich D (2007). A genomewide admixture map for Latino populations.. The American Journal of Human Genetics, 80, 1024 - 1036. doi:10.1086/518313
    • Marrero AR, Bravi C, Stuart S, Long JC, Pereira das Neves Leite F, Kommers T, Carvalho CM, Pena SD, Ruiz-Linares A, Salzano FM, Cátira Bortolini M (2007). Pre- and post-Columbian gene and cultural continuity: the case of the Gaucho from southern Brazil.. Hum Hered, 64(3), 160 - 171. doi:10.1159/000102989
    • Marrero AR, Silva-Junior WA, Bravi CM, Hutz MH, Petzl-Erler ML, Ruiz-Linares A, Salzano FM, Bortolini MC (2007). Demographic and evolutionary trajectories of the Guarani and Kaingang natives of Brazil.. Am J Phys Anthropol, 132(2), 301 - 310. doi:10.1002/ajpa.20515

    2006

    • Miranda A, García J, López C, Gordon D, Palacio C, Restrepo G, Ortiz J, Montoya G, Cardeño C, Calle J, López M, Campo O, Bedoya G, Ruiz-Linares A, Ospina-Duque J (2006). Putative association of the carboxy-terminal PDZ ligand of neuronal nitric oxide synthase gene (CAPON) with schizophrenia in a Colombian population.. Schizophr Res, 82(2-3), 283 - 285. doi:10.1016/j.schres.2005.10.018
    • Pineda-Trujillo N, Apergi M, Moreno S, Arias W, Lesage S, Franco A, Sepulveda-Falla D, Cano D, Buritica O, Pineda D, Uribe CS, de Yebenes JG, Lees AJ, Brice A, Bedoya G, Lopera F, Ruiz-Linares A (2006). A genetic cluster of early onset Parkinson's disease in a Colombian population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141(8), 885 - 889. doi:10.1002/ajmg.b.30375
    • Service S, DeYoung J, Karayiorgou M, Roos JL, Pretorious H, Bedoya G, Ospina J, Ruiz-Linares A, Macedo A, Palha JA, Heutink P, Aulchenko Y, Oostra B, van Duijn C, Jarvelin M-J, Varilo T, Peddle L, Rahman P, Piras G, Monne M, Murray S, Galver L, Peltonen L, Sabatti C, Collins A, Freimer N (2006). Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies. Nature Genetics, 38(5), 556 - 560. doi:10.1038/ng1770
    • Pereira TV, Salzano FM, Mostowska A, Trzeciak WH, Ruiz-Linares A, Chies JA, Saavedra C, Nagamachi C, Hurtado AM, Hill K, Castro-de-Guerra D, Silva-Júnior WA, Bortolini MC (2006). Natural selection and molecular evolution in primate PAX9 gene, a major determinant of tooth development.. Proc Natl Acad Sci U S A, 103(15), 5676 - 5681. doi:10.1073/pnas.0509562103
    • Torres MM, Bravi CM, Bortolini MC, Duque C, Callegari-Jacques S, Ortiz D, Bedoya G, Groot de Restrepo H, Ruiz-Linares A (2006). A revertant of the major founder Native American haplogroup C common in populations from northern South America.. Am J Hum Biol, 18(1), 59 - 65. doi:10.1002/ajhb.20461
    • Bedoya G, Montoya P, Garcia J, Soto I, Bourgeois S, Carvajal L, Labuda V, Alvarez J, Ospina P, Hedrick W, Ruiz-Linares A (2006). Admixture dynamics in Hispanics: a shift in the nuclear genetic ancestry of a South American population isolate. Proceedings of the National Academy of Sciences of the United States of America, 103(19), 7234 - 7239. doi:10.1073/pnas.0508716103
    • Herzberg I, Jasinska A, García J, Jawaheer D, Service S, Kremeyer B, Duque C, Parra MV, Vega J, Ortiz D, Carvajal L, Polanco G, Restrepo GJ, López C, Palacio C, Levinson M, Aldana I, Mathews C, Davanzo P, Molina J, Fournier E, Bejarano J, Ramírez M, Ortiz CA, Araya X, Sabatti C, Reus V, Macaya G, Bedoya G, Ospina J, Freimer N, Ruiz-Linares A (2006). Convergent linkage evidence from two Latin-American population isolates supports the presence of a susceptibility locus for bipolar disorder in 5q31-34.. Hum Mol Genet, 15(21), 3146 - 3153. doi:10.1093/hmg/ddl254
    • Choo KE, Nicoli TK, Bruce LJ, Tanner MJ, Ruiz-Linares A, Wrong OM (2006). Recessive distal renal tubular acidosis in Sarawak caused by AE1 mutations.. Pediatr Nephrol, 21(2), 212 - 217. doi:10.1007/s00467-005-2061-z
    • Glatt CE, Wahner AD, White DJ, Ruiz-Linares A, Ritz B (2006). Gain-of-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in women.. Hum Mol Genet, 15(2), 299 - 305. doi:10.1093/hmg/ddi445
    • Kremeyer B, Herzberg I, Garcia J, Kerr E, Duque C, Parra V, Vega J, Lopez C, Palacio C, Bedoya G, Ospina J, Ruiz-Linares A (2006). Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate.. Am J Med Genet B Neuropsychiatr Genet, 141B(5), 435 - 439. doi:10.1002/ajmg.b.30354

    2005

    • Pineda-Trujillo N, Cornejo W, Carrizosa J, Wheeler RB, Munera S, Valencia A, Agudelo-Arango J, Cogollo A, Anderson G, Bedoya G, Mole SE, Ruiz-Linares A (2005). A CLN5 mutation causing an atypical neuronal ceroid lipofuscinosis of juvenile onset. Neurology, 64(4), 740 - 742.
    • Marrero AR, Das Neves Leite FP, De Almeida Carvalho B, Peres LM, Kommers TC, Da Cruz IM, Salzano FM, Ruiz-Linares A, Da Silva Júnior WA, Bortolini MC (2005). Heterogeneity of the genome ancestry of individuals classified as White in the state of Rio Grande do Sul, Brazil.. Am J Hum Biol, 17(4), 496 - 506. doi:10.1002/ajhb.20404
    • Pineda-Trujillo N, Carrizosa J, Cornejo W, Arias W, Franco C, Cabrera C, Bedoya G, Ruíz-Linares A (2005). A novel SCN1A mutation associated with severe GEFS+ in a large South American pedigree.. Epilepsy, 14, 123 - 128.

    2004

    • Bortolini MC, Thomas MG, Chikhi L, Aguilar JA, Castro-De-Guerra D, Salzano FM, Ruiz-Linare A (2004). Ribeiro’s typology, genomes, and Spanish colonialism, as viewed from Gran Canaria and Colombia. Genetics and Molecular Biology, 27(1), 1 - 8. doi:10.1590/S1415-47572004000100001
    • Ruiz-Linares A (2004). Juvenile Parkinson's Disease and the C212Y mutation of parkin. Archives of Neurology, 61(3), 444 - 444.
    • Bortolini MC, Thomas MG, Chikhi L, Ruiz-Linares A (2004). Ribeiro's typology genomes and Spanish colonialism. Genetics and Molecular Biology, 27(1), 1 - 8.

    2003

    • Bortolini MC, Salzano FM, Thomas MG, Bau CHD, Layrisse Z, Petzl-Erler ML, Tsuneto LT, Hill K, Hurtado AM, Castro-de-Guerra D, Torres MM, Groot H, Michalski R, Nymadawa P, Bedoya G, Bradman N, Labuda D, Ruiz-Linares A (2003). Y-chromosome evidence for differing ancient demographic histories in the Americas. The American Journal of Human Genetics, 73, 524 - 539. doi:10.1086/377588
    • Carvajal-Carmona LG, Bermudez N, Olivera-Angel M, Estrada L, Ossa J, Bedoya G, Ruiz Linares A (2003). Abundant mtDNA diversity and ancestral admixture in Colombian criollo cattle (Bos taurus). Genetics, 165, 1457 - 1463.
    • Carvajal-Carmona LG, Ophoff R, Jaana Hartiala SS, Molina J, Leon P, Ospina J, Bedoya G, Freimer N, Ruiz-Linares A (2003). Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica. Human Genetics, 112, 534 - 541.

    2002

    • Ramírez-Castro JL, Pineda-Trujillo N, Valencia AV, Muñetón CM, Botero O, Trujillo O, Vásquez G, Mora BE, Durango N, Bedoya G, Ruiz-Linares A (2002). Mutations in FOXL2 underlying BPES (types 1 and 2) in Colombian families.. Am J Med Genet, 113(1), 47 - 51. doi:10.1002/ajmg.10741
    • Bortolini MC, Salzano FM, Bau CH, Layrisse Z, Petzl-Erler ML, Tsuneto LT, Hill K, Hurtado AM, Castro-De-Guerra D, Bedoya G, Ruiz-Linares A (2002). Y-chromosome biallelic polymorphisms and Native American population structure.. Ann Hum Genet, 66(Pt 4), 255 - 259. doi:10.1017/S0003480002001148

    2001

    • Pineda-Trujillo N, Carvajal-Carmona LG, Buritica O, Moreno S, Uribe CS, Pineda D, Toro ME, Garcia F, Arias W, Bedoya G, Lopera F, Ruiz-Linares A (2001). A novel Cys212Tyr founder mutation in parkin and allelic heterogeneity of juvenile Parkinsonism in a population from North West Colombia. Neuroscience Letters, 298(2), 87 - 90. doi:10.1016/S0304-3940(00)01733-X
    • Bortolini M, Salzano F, Bau C, Layrisse Z, Petzl-Erler M, Tsuneto L, Hill K, Hurtado A, Castro-de-Guerra D, Bedoya G, Ruiz-Linares A (2001). Y-chromosome biallelic polymorphisms and Native American population structure.. AM J HUM GENET, 69(4), 423 - 423.
    • Bourgeois S, Zietkiewicz E, Yotova V, Michalski R, Ruiz-Linares A, Labuda D (2001). Founder effects and the peopling of the New World.. AM J HUM GENET, 69(4), 398 - 398.

    2000

    • Carvajal-Carmona L, Soto I, Pineda N, Ortiz-Barrientos D, Duque C, Ospina-Duque J, McCarthy M, Montoya P, Alvarez VM, Bedoya G, Ruiz-Linares A (2000). Strong Amerind/Caucasoid gender bias and a possible Sephardic contribution among the founders of population in North West Colombia. The American Journal of Human Genetics, 67, 1287 - 1295.
    • Cu'llar-Ambrosi F, Mondrag n MC, Figueroa M, Pr'hu C, Galact'ros F, Ruiz-Linares A (2000). Sickle Cell Anemia and -Globin Gene Cluster Haplotypes in Colombia. Hemoglobin, 24, 221 - 225.
    • Ospina-Duque J, Duque C, Carvajal-Carmona L, Ortiz-Barrientos D, Soto I, Pineda N, Cuartas M, Calle J, L pez C, Ochoa L, Ruiz-Linares A (2000). An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a population isolate from Colombia. Neuroscience Letters, 292, 199 - 202.
    • Mesa NR, Mondrag n MC, Soto ID, Parra MV, Duque C, Ort z-Barrientos D, Garc a LF, Velez ID, Bravo ML, M nera JG, Bedoya G, Bortolini MC, Ruiz-Linares A (2000). Autosomal, mtDNA and Y-chromosome diversity in Amerinds: pre and post-Colombian patterns of gene flow in South America. The American Journal of Human Genetics, 67, 1277 - 1286.

    1999

    • Ruiz-Linares A, Ortíz-Barrientos D, Figueroa M, Mesa N, Múnera JG, Bedoya G, Vélez ID, García LF, Pérez-Lezaun A, Bertranpetit J, Feldman MW, Goldstein DB (1999). Microsatellites provide evidence for Y chromosome diversity among the founders of the New World.. Proc Natl Acad Sci U S A, 96(11), 6312 - 6317.

    1997

    • Lopera F, Ardilla A, Martínez A, Madrigal L, Arango-Viana JC, Lemere CA, Arango-Lasprilla JC, Hincapíe L, Arcos-Burgos M, Ossa JE, Behrens IM, Norton J, Lendon C, Goate AM, Ruiz-Linares A, Rosselli M, Kosik KS (1997). Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation.. JAMA, 277(10), 793 - 799.

    1996

    • Ruiz Linares A, Nayar K, Goldstein DB, Hebert JM, Seielstad MT, Underhill PA, Lin AA, Feldman MW, Cavalli Sforza LL (1996). Geographic clustering of human Y-chromosome haplotypes.. Ann Hum Genet, 60(Pt 5), 401 - 408.

    1995

    • Goldstein DB, Ruiz Linares A, Cavalli-Sforza LL, Feldman MW (1995). Genetic absolute dating based on microsatellites and the origin of modern humans.. Proc Natl Acad Sci U S A, 92(15), 6723 - 6727.
    • Goldstein DB, Ruiz Linares A, Cavalli-Sforza LL, Feldman MW (1995). An evaluation of genetic distances for use with microsatellite loci.. Genetics, 139(1), 463 - 471.

    1994

    • Bowcock AM, Ruiz-Linares A, Tomfohrde J, Minch E, Kidd JR, Cavalli-Sforza LL (1994). High resolution of human evolutionary trees with polymorphic microsatellites.. Nature, 368(6470), 455 - 457. doi:10.1038/368455a0

    1993

    • Ruiz-Linares A (1993). Dinucleotide repeat polymorphism in the interferon-gamma (IFNG) gene.. Hum Mol Genet, 2(9), 1508 - .

    1991

    • Ruiz Linares A, Hancock JM, Dover GA (1991). Secondary structure constraints on the evolution of Drosophila 28 S ribosomal RNA expansion segments.. J Mol Biol, 219(3), 381 - 390.

    1990

    • Desprès P, Ruiz-Linarès A, Cahour A, Girard M, Wychowski C, Bouloy M (1990). The 15 amino acid residues preceding the amino terminus of the envelope protein in the yellow fever virus polyprotein precursor act as a signal peptide.. Virus Res, 16(1), 59 - 75.

    1989

    • Ruiz-Linares A, Cahour A, Després P, Girard M, Bouloy M (1989). Processing of yellow fever virus polyprotein: role of cellular proteases in maturation of the structural proteins.. J Virol, 63(10), 4199 - 4209.
    • Ruiz-Linares A, Bouloy M, Girard M, Cahour A (1989). Modulations of the in vitro translational efficiencies of Yellow Fever virus mRNAs: interactions between coding and noncoding regions.. Nucleic Acids Res, 17(7), 2463 - 2476.