Prof Gordon Stewart

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Personal Profile

Name: Gordon Stewart Email: g.stewart@ucl.ac.uk
Title: Prof Tel: 07776 188438
Department: Internal Medicine Fax:
Position: Professor of Experimental Medicine Address: Rayne Building, University Street, London, WC1E 6JJ
Research Domain: Personalised Medicine Web Page:  

Profile

Research Description

We aim to elucidate the pathophysiology underlying a series of congenital red cell disorders in which the membrane 'leaks' monovalent cations sodium and potassium.

Research Activities

Clinical Abnormalities of the Red Cell Membrane

Education Description

I am involved in the ward teaching of First Year Clinical students. I am Sub-dean for the MBPhD programme.

UCL Collaborators

External Collaborators

Publications

    2012

    • Bawazir WM, Gevers EF, Flatt JF, Ang AL, Jacobs B, Oren C, Grunewald S, Dattani M, Bruce LJ, Stewart GW (2012). An infant with pseudohyperkalemia, hemolysis, and seizures: cation-leaky GLUT1-deficiency syndrome due to a SLC2A1 mutation.. J Clin Endocrinol Metab, 97(6), E987 - E993. doi:10.1210/jc.2012-1399

    2011

    • Flatt JF, Guizouarn H, Burton N, Borgese F, Tomlinson RJ, Forsyth RJ, Baldwin SA, Levinson BE, Quittet P, Aguilar-Martinez P, Delaunay J, Stewart GW, Bruce LJ (2011). A haemato-neurological disease caused by mutations in SLC2A1, coding for the GLUT1 glucose transporter.
    • Guizouarn H, Borgese F, Gabillat N, Harrison P, Goede JS, McMahon C, Stewart GW, Bruce LJ (2011). South-east Asian ovalocytosis and the cryohydrocytosis form of hereditary stomatocytosis show virtually indistinguishable cation permeability defects.. Br J Haematol, 152(5), 655 - 664. doi:10.1111/j.1365-2141.2010.08454.x
    • Flatt JF, Guizouarn H, Burton NM, Borgese F, Tomlinson RJ, Forsyth RJ, Baldwin SA, Levinson BE, Quittet P, Aguilar-Martinez P, Delaunay J, Stewart GW, Bruce LJ (2011). Stomatin-deficient cryohydrocytosis results from mutations in SLC2A1: a novel form of GLUT1 deficiency syndrome. BLOOD, 118(19), 5267 - 5277. doi:10.1182/blood-2010-12-326645

    2010

    • Stewart GW (2010). Core Clinical Medicine. Clinical talk..
    • Walsh SB, Stewart GW (2010). Anion exchanger 1: Protean function and associations.. Int J Biochem Cell Biol, 42(12), 1919 - 1922. doi:10.1016/j.biocel.2010.08.016

    2009

    • Bruce LJ, Guizouarn H, Burton NM, Gabillat N, Poole J, Flatt JF, Brady RL, Borgese F, Delaunay J, Stewart GW (2009). The monovalent cation leak in overhydrated stomatocytic red blood cells results from amino acid substitutions in the Rh-associated glycoprotein. BLOOD, 113(6), 1350 - 1357. doi:10.1182/blood-2008-07-171140
    • Ellory JC, Guizouarn H, Borgese F, Bruce LJ, Wilkins RJ, Stewart GW (2009). Leaky Cl- -HCO3- exchangers: cation fluxes via modified AE1. PHILOS T R SOC B, 364(1514), 189 - 194. doi:10.1098/rstb.2008.0154

    2008

    • Wilkinson DK, Turner EJ, Parkin ET, Garner AE, Penny JH, Crawford M, Stewart GW, Hooper NM (2008). Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis. BBA-BIOMEMBRANES, 1778(1), 125 - 132. doi:10.1016/j.bbamem.2007.09.016

    2006

    • Caterino M, Ruoppolo M, Orru S, Savoia M, Perrotta S, Del Vecchio L, Salvatore F, Stewart GW, Iolascon A (2006). Characterization of red cell membrane proteins as a function of red cell density: Annexin VII in different forms of hereditary spherocytosis. FEBS LETT, 580(28-29), 6527 - 6532. doi:10.1016/j.febslet.2006.10.070
    • Stewart GW, Lloyd J, Pegel K (2006). Mediterranean stomatocytosis/macrothrombocytopenia: Update from Adelaide, Australia. BRIT J HAEMATOL, 132(5), 660 - 661. doi:10.1111/j.1365-2141.2005.05943.x
    • Syfuss PY, Ciupea A, Brahimi S, Cynober T, Stewart GW, Grandchamp B, Beaumont C, Tchernia G, Delaunay J, Wagner JC (2006). Mild dehydrated hereditary stomatocytosis revealed by marked hepatosiderosis. CLIN LAB HAEMATOL, 28(4), 270 - 274. doi:10.1111/j.1365-2257.2006.00774.x

    2005

    • Fricke B, Parsons SF, Knopfle G, von During M, Stewart GW (2005). Stomatin is mis-trafficked in the erythrocytes of overhydrated hereditary stomatocytosis, and is absent from normal primitive yolk sac-derived erythrocytes.. British Journal of Haematology, Oct;131(2), 265 - 277.
    • Rees DC, Iolascon A, Carella M, O'Marcaigh AS, Kendra JR, Jowitt SN, Wales JK, Vora A, Makris M, Manning N, Nicolaou A, Fisher J, Mann A, Machin SJ, Clayton PT, Gasparini P, Stewart GW (2005). Stomatocytic haemolysis and macrothrombocytopenia (Mediterranean stomatocytosis/macrothrombocytopenia) is the haematological presentation of phytosterolaemia. British Journal of Haematology, 130(2), 297 - 309. doi:10.1111/j.1365-2141.2005.05599.x
    • Bruce LJ, Robinson HC, Guizouarn H, Borgese F, Harrison P, King MJ, Goede JS, Coles SE, Gore DM, Lutz HU, Ficarella R, Layton M, Iolascon A, Ellory JC, Stewart GW (2005). Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1.. Nature Genetics, 37(11), 1258 - 1263. doi:10.1038/ng1656
    • Rees DC, Iolascon A, Carella M, O'Marcaigh AS, Kendra JR, Jowitt SN, Wales JK, Vora A, Makris M, Manning N, Nicolaou A, Fisher J, Mann A, Machin SJ, Clayton PT, Gasparini P, Stewart GW (2005). Stomatocytic haemolysis and macrothrombocytopenia (Mediterranean stomatocytosis/macrothrombocytopenia) is the haematological presentation of phytosterolaemia. BRIT J HAEMATOL, 130(2), 297 - 309. doi:10.1111/j.1365-2141.2005.05599.x

    2004

    • Stewart GW (2004). Hemolytic disease due to membrane ion channel disorders.. Current Opinion in Hematology, Jul;11(4), 244 - 250.
    • Barnes K, Ingram JC, Bennett MD, Stewart GW, Baldwin SA (2004). Methyl-beta-cyclodextrin stimulates glucose uptake in Clone 9 cells: a possible role for lipid rafts.. Biochemical Journal, Mar 1;378(Pt 2), 343 - 351.
    • Carella M, d'Adamo AP, Grootenboer-Mignot S, Vantyghem MC, Esposito L, D'Eustacchio A, Ficarella R, Stewart GW, Gasparini P, Delaunay J, Iolascon A (2004). A second locus mapping to 2q35-36 for familial pseudohyperkalaemia. European Journal of Human Genetics, Dec;12(12), 1073 - 1076.
    • Rees DC, Portmann B, Ball C, Mieli-Vergani G, Nicolaou A, Chetty MC, Stewart GW (2004). Dehydrated hereditary stomatocytosis is associated with neonatal hepatitis.. British Journal of Haematology, Jul;126(2), 272 - 276.
    • Stewart GW, Delaunay J (2004). Disorders of the Red Cell Membrane. In Runge MS, Paterson C, Thien SL (Ed.), Principles of Molecular Medicine (pp. - ). : Humana.
    • Gore DM, Layton M, Sinha AK, Williamson PJ, Vaidya B, Connolly V, Mannix P, Chetty MC, Nicolaou A, Stewart GW (2004). Four pedigrees of the cation-leaky hereditary stomatocytosis class presenting with pseudohyperkalaemia. Novel profile of temperature dependence of Na+-K+ leak in a xerocytic form.. British Journal of Haematology, 125(4), 521 - 527. doi:10.1111/j.1365-2141.2004.04944.x
    • Argent AC, Chetty MC, Fricke B, Bertrand Y, Philippe N, Khogali S, von During M, Delaunay J, Stewart GW (2004). A family showing recessively inherited multisystem pathology with aberrant splicing of the erythrocyte Band 7.2b ('stomatin') gene.. Journal of Inherited Metabolic Disease, 27(1), 29 - 46.
    • Fricke B, Jarvis HG, Reid CD, Aguilar-Martinez P, Robert A, Quittet P, Chetty M, Pizzey A, Cynober T, Lande WF, Mentzer WC, During M, Winter S, Delaunay J, Stewart GW (2004). Four new cases of stomatin-deficient hereditary stomatocytosis syndrome: association of the stomatin-deficient cryohydrocytosis variant with neurological dysfunction.. , , - .
    • Green JB, Fricke B, Chetty MC, von During M, Preston GF, Stewart GW (2004). Eukaryotic and prokaryotic stomatins: the proteolytic link.. Blood Cells, Molecules, and Diseases, May-Jun;32(3), 411 - 422.

    2003

    • Jarvis HG, Gore DM, Briggs C, Chetty MC, Stewart GW (2003). Cold storage of 'cryohydrocytosis' red cells: the osmotic susceptibility of the cold-stored erythrocyte.. British Journal of Haematology, 122(5), 859 - 868.
    • Stewart GW (2003). The Hereditary Stomatocytoses and Allied Conditions’: inherited disorders Na and K transport across the red cell membrane.. In Ellory JC, Bernhardt I (Ed.), The Red Cell Membrane, (pp. 511 - 524). : Karger.
    • Stewart GW, Fricke B (2003). The curious genomic path from leaky red cell to nephrotic kidney.. Nephron Physiol, 93(2), p29 - p33.
    • Basu AP, Carey P, Cynober T, Chetty M, Delaunay J, Stewart GW, Richmond S (2003). Dehydrated hereditary stomatocytosis with transient perinatal ascites.. Archives of Disease in Childhood - Fetal and Neonatal Edition, 88(5), F438 - F439.
    • Fricke B, Stewart GW, Treharne KJ, Mehta A, Knopfle G, Friedrichs N, Muller KM, von During M (2003). Stomatin immunoreactivity in ciliated cells of the human airway epithelium.. Anatomy and Embryology, 207(1), 1 - 7.
    • Turner EJ, Jarvis HG, Chetty MC, Landon G, Rowley PS, Ho MM, Stewart GW (2003). ATP-dependent vesiculation in red cell membranes from different hereditary stomatocytosis variants.. British Journal of Haematology, 120(5), 894 - 902.
    • Iolascon A, Perrotta S, Stewart GW (2003). Red blood cell membrane defects.. Reviews in Clinical and Experimental Hematology, 7(1), 22 - 56.
    • Fricke B, Argent AC, Chetty MC, Pizzey AR, Turner EJ HOMM, Iolascon A, von During M, Stewart GW (2003). The "stomatin" gene and protein in overhydrated hereditary stomatocytosis.. Blood, 102(6), 2268 - 2277. doi:10.1182/blood-2002-06-1705
    • Bergheim J, Ernst P, Brinch L, Gore DM, Chetty MC, Stewart GW (2003). Allogeneic bone marrow transplantation for severe post-splenectomy thrombophilic state in leaky red cell membrane haemolytic anaemia of the stomatocytosis class.. British Journal of Haematology, 121(1), 119 - 122.

    2002

    • Gore DM, Chetty MC, Fisher J, Nicolaou A, Stewart GW (2002). Familial pseudohyperkalaemia Cardiff: a mild version of cryohydrocytosis.. British Journal of Haematology, 117(1), 212 - 214.
    • Latham T, Stewart GW, Horn EH (2002). Recurrent thromboembolism in a familial pseudohyperkalaemia patient with an intact spleen.. British Journal of Haematology, 119(4), 1141 - .
    • Bruce LJ, Ghosh S, King MJ, Layton DM, Mawby WJ, Stewart GW, Oldenborg PA, Delaunay J, Tanner MJ (2002). Absence of CD47 in protein 4.2-deficient hereditary spherocytosis in man: an interaction between the Rh complex and the band 3 complex.. Blood, 100(5), 1878 - 1885.

    2001

    • Haines PG, Jarvis HG, King S, Noormohamed FH, Chetty MC, Fisher J, Hill P, Nicolaou A, Stewart GW (2001). Two further British families with the 'cryohydrocytosis' form of hereditary stomatocytosis. British Journal of Haematology, 113(4), 932 - 937.
    • Chetty MC, Stewart GW (2001). Pseudohyperkalaemia and pseudomacrocytosis caused by inherited red-cell disorders of the 'hereditary stomatocytosis' group. British Journal of Biomedical Science, 58(1), 48 - 55.
    • Jarvis HG, Chetty MC, Nicolaou A, Fisher J, Miller A, Stewart GW (2001). A novel stomatocytosis variant showing marked abnormalities in intracellular [Na] and [K] with minimal haemolysis. European Journal of Haematology, 66(6), 412 - 414.
    • Haines PG, Crawley C, Chetty MC, Jarvis H, Coles SE, Fisher J, Nicolaou A, Stewart GW (2001). Familial pseudohyperkalaemia Chiswick: a novel congenital thermotropic variant of K and Na transport across the human red cell membrane. British Journal of Haematology, 112(2), 469 - 474.

    2000

    • Grootenboer S, Schischmanoff PO, Laurendeau I, Cynober T, Tchernia G, Dommergues JP, Dhermy D, Bost M, Varet B, Snyder M, Ballas SK, Ducot B, Babron MC, Stewart GW, Gasparini P, Iolascon A, Delaunay J (2000). Pleiotropic syndrome of dehydrated hereditary stomatocytosis, pseudohyperkalemia, and perinatal edema maps to 16q23-q24.. Blood, 96(7), 2599 - 2605.
    • Gibson JS, Stewart GW, Ellory JC (2000). Effect of dimethyl adipimidate on K+ transport and shape change in red blood cells from sickle cell patients.. FEBS Letters, 480(2), 179 - 183.
    • Haines PG, Crawley C, Chetty MC, Coles SE, Stewart GW (2000). A novel congenital thermotropic anomaly of K+ transport across the human red cell membrane. J PHYSIOL-LONDON, 523, 232P - 232P.

    1999

    • Coles SE, Chetty MC, Ho MM, Nicolaou A, Kearney JW, Wright SD, Stewart GW (1999). Two British families with variants of the 'cryohydrocytosis' form of hereditary stomatocytosis. British Journal of Haematology, 105(4), 1055 - 1065.
    • Stewart GW, Turner EJ (1999). The hereditary stomatocytoses and allied disorders: congenital disorders of erythrocyte membrane permeability to Na and K.. Best Practice and Research Clinical Haematology, 12(4), 707 - 727.
    • Iolascon A, Stewart GW, Ajetunmobi JF, Perrotta S, Delaunay J, Carella M, Zelante L, Gasparini P (1999). Familial pseudohyperkalemia maps to the same locus as dehydrated hereditary stomatocytosis (hereditary xerocytosis). Blood, 93(9), 3120 - 3123.
    • Coles SE, Stewart GW (1999). Temperature effects on cation transport in hereditary stomatocytosis and allied disorders. International Journal of Experimental Pathology, 80(5), 251 - 258.
    • Coles SE, Ho MM, Chetty MC, Nicolaou A, Stewart GW (1999). A variant of hereditary stomatocytosis with marked pseudohyperkalaemia. British Journal of Haematology, 104(2), 275 - 283.
    • Carella M, Stewart GW, Ajetunmobi JF, Schettini Jr F, Delaunay J, Iolascon A (1999). Genetic heterogeneity of hereditary stomatocytosis syndromes showing pseudohyperkalemia [letter]. Haematologica, 84(9), 862 - 863.
    • Delaunay J, Stewart G, Iolascon A (1999). Hereditary dehydrated and overhydrated stomatocytosis: recent advances. Current Opinion in Hematology, 6(2), 110 - 114.

    1998

    • Ellory JC, Gibson JS, Stewart GW (1998). Pathophysiology of abnormal cell volume in human red cells.. Contributions to Nephrology, 123, 220 - 239.
    • Sinard JH, Stewart GW, Stabach PR, Argent AC, Gilligan DM, Morrow JS (1998). Utilization of an 86 bp exon generates a novel adducin isoform (beta 4) lacking the MARCKS homology domain. BIOCHIM BIOPHYS ACTA, 1396(1), 57 - 66.
    • Carella M, Stewart G, Ajetunmobi JF, Perrotta S, Grootenboer S, Tchernia G, Delaunay J, Totaro A, Zelante L, Gasparini P, Iolascon A (1998). Genomewide search for dehydrated hereditary stomatocytosis (hereditary xerocytosis): mapping of locus to chromosome 16 (16q23-qter). The American Journal of Human Genetics, 63(3), 810 - 816.

    1997

    • Stewart GW (1997). Stomatin. INT J BIOCHEM CELL BIOL, 29(2), 271 - 274.
    • Ho MM, Nicolaou A, Argent AC, Stewart GW (1997). Trans-bilayer phospholipid movements in human red blood cells deficient in the 32 kDa Band-7.2b membrane protein, 'stomatin'. Biochemical Society Transactions, 25(3), 492S - .

    1996

    • Stewart GW, Amess JA, Eber SW, Kingswood C, Lane PA, Smith BD, Mentzer WC (1996). Thrombo-embolic disease after splenectomy for hereditary stomatocytosis.. British Journal of Haematology, 93(2), 303 - 310.

    1995

    • SINARD JH, STEWART GW, ARGENT AC, GILLIGAN DM, MORROW JS (1995). A NOVEL ISOFORM OF BETA-ADDUCIN UTILIZES AN ALTERNATIVELY SPLICED EXON NEAR THE C-TERMINUS. MOL BIOL CELL, 6, 1562 - 1562.

    1993

    • Stewart GW, Argent AC, Dash BC (1993). Stomatin: a putative cation transport regulator in the red cell membrane.. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1225(1), 15 - 25.
    • Stewart GW (1993). The membrane defect in hereditary stomatocytosis.. Baillière's Clinical Haematology, 6(2), 371 - 399.
    • Stewart GW (1993). The membrane defect in hereditary stomatocytosis. In Tanner MJA, Anstee DJ (Ed.), Red cell membrane antigens (pp. 371 - 400). : Bailliere-Tyndall.

    1992

    • Stewart GW, Hepworth-Jones BE, Keen JN, Dash BC, Argent AC, Casimir CM (1992). Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes.. Blood, 79(6), 1593 - 1601.
    • Stewart GW, Argent AC (1992). Integral band 7 protein of the human erythrocyte membrane.. Biochemical Society Transactions, 20(4), 785 - 790.

    1991

    • Stewart GW (1991). 'Physiological membrane stabilisation': a possible explanation for the K(+)-H+ and K(+)-Mg2+ relations in disease.. Miner Electrolyte Metab, 17(5), 345 - 352.

    1989

    • Stewart GW, Blackstock EJ, Hall AC, Ellory JC (1989). Potassium transport in monkey erythrocytes.. Experimental Biology, 48(3), 167 - 172.
    • Stewart GW, Blackstock EJ (1989). Potassium transport in rabbit erythrocytes.. Experimental Biology, 48(3), 161 - 165.
    • Stewart GW, Ellory JC (1989). Chloride-dependent K and Na Transport in human red cells.. In Raes B (Ed.), The Red Cell Membrane (pp. 281 - 302). : Humana Press.

    1988

    • Stewart GW (1988). Co-ordinated variations in chloride-dependent potassium transport and cell water in normal human erythrocytes.. The Journal of Physiology, 401, 1 - 16.

    1987

    • Stewart GW, O'Brien H, Morris SA, Owen JS, Lloyd JK, Ames JA (1987). Stomatocytosis, abnormal platelets and pseudo-homozygous hypercholesterolaemia.. European Journal of Haematology, 38(4), 376 - 380.

    1986

    • Stewart GW, Freegard SP, Keeling DH, Perrett AD (1986). Cyanosis attributable to right to left shunt in carcinoid syndrome.. British Medical Journal (Clinical Research Ed.), 292(6520), 589 - 590.
    • Blackstock EJ, Stewart GW (1986). The dependence on external cation of sodium and potassium fluxes across the human red cell membrane at low temperatures.. The Journal of Physiology, 375, 403 - 420.

    1985

    • Stewart GW (1985). Inherited disorders of red cell cation transport.. In Belton NR, Toothill C (Ed.), Transport and Inherited Disease (pp. 333 - 346). : MTP.
    • Stewart GW, Ellory JC (1985). Volume-sensitive passive potassium fluxes in red cells.. In Gilles R (Ed.), (pp. 400 - 410). : Springer-verlag.
    • Stewart GW, Ellory JC (1985). A family with mild hereditary xerocytosis showing high membrane cation permeability at low temperatures.. Clinical Science, 69(3), 309 - 319.

    1983

    • Ellory JC, Flatman PW, Stewart GW (1983). Inhibition of human red cell sodium and potassium transport by divalent cations.. The Journal of Physiology, 340, 1 - 17.

    1982

    • Ellory JC, Dunham PB, Logue PJ, Stewart GW (1982). Anion-dependent cation transport in erythrocytes.. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences, 299(1097), 483 - 495.
    • Ellory JC, Stewart GW (1982). The human erythrocyte Cl-dependent Na-K cotransport system as a possible model for studying the action of loop diuretics.. British Journal of Pharmacology, 75(1), 183 - 188.

    1981

    • Stewart GW, Peart WS, Boylston AW (1981). Obstructive jaundice, pancytophenia and hydralazine.. The Lancet, 1(8231), 1207 - .

    1980

    • Dunham PB, Stewart GW, Ellory JC (1980). Chloride-activated passive potassium transport in human erythrocytes.. Proceedings of the National Academy of Sciences of the United States of America, 77(3), 1711 - 1715.
    • Stewart GW, Ellory JC, Klein RA (1980). Increased human red cell cation passive permeability below 12 degrees C.. Nature, 286(5771), 403 - 404.
    • Brooks AP, Stewart GW, Baird JD (1980). Spontaneous hypoglycaemia in active acromegaly and its response to bromocriptine.. British Medical Journal, 280(6221), 1070 - .

    1979

    • Corrall RJ, Stewart GW, Ratcliffe JG (1979). Acute adrenal insufficiency due to isolated corticotrophin deficiency.. Journal of the Royal Society of Medicine, 72(7), 530 - 532.
    • Stewart GW, Corrall RJ, Fyffe JA, Stockdill G, Strong JA (1979). Familial pseudohyperkalaemia. A new syndrome.. The Lancet, 2(8135), 175 - 177.

    • Stewart GW, Wilmore SMS (). Questions of cell shape. In Walker R, Saiki S, Danek A (Ed.), Neuroacanthocytosis Syndromes II. (pp. 115 - 132). : Springer.
    • Stewart GW, Ellory JC, Gibson J (). Pathophysiology of abnormal cell volume in human red cells. In (Ed.), Cell Volume Regulation (pp. 120 - 139). : Karger.