Dr Liz Sampson

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Personal Profile

Name: Liz Sampson Email: e.sampson@ucl.ac.uk
Title: Dr Tel: 020 7679 9730
Department: Division of Psychiatry Fax: 020 7679 9426
Position: Senior Clinical Lecturer Address: Charles Bell House, 67-73 Riding House Street, London, W1W 7EJ
Research Domain: Ageing, Neuroscience, Populations & Lifelong Health Web Page: Personal Web Page

Profile

Research Description

My work is suported by the Marie Curie Palliative Care Research Unit.

PALLIATIVE AND END OF LIFE CARE IN DEMENTIA
Epidemiology and health services research: to identify barriers to access to good quality palliative and end of life care for older people, complex interventions to improve care in a range of settings

-The CoMPASs:IOn Programme (Care Of Memory Problems in Advanced Stages: Improving Our kNowledge). A 3 year programme grant funded by Marie Curie Cancer Care UK to develop new interventions to improve end of life care forpeople with dementia

-Pain in Impaired Cognition. COST "European Cooperation in the Field of Scientific and Technical Research".  Action brings together leading researchers from a wide range of scientific disciplines. The major aim is the development of a comprehensive and internationally agreed-on assessment toolkit for older adults targeting the various subtypes of dementia and various aspects of pain, including pain diagnostics, cognitive examination and guidelines for proper assessment. http://www.cost-td1005.net/

-The SEED programme (PI Prof. L Robinson) This programme  aims to support professionals to deliver good quality, community-based end of life care in dementia. Firstly we will review current guidance and existing care pathways. We will also work with people with dementia, carers and professionals to examine how professionals deliver end of life care to people with dementia and their families, looking for examples of best practice and solutions to meet dementia-specific problems. Combining the above data, we will develop an intervention based on Individual Care Planning (ICP) and then see how the ICP fits into practice, if it is used by staff and whether it improves the quality of care provided. Finally we will create guidance for clinical commissioners on the provision of good quality end of life care in dementia. http://research.ncl.ac.uk/seed/

-The MARQUE study (PI  Prof. G Livingston) This study aims to increase knowledge of agitation, a distressing symptom which occurs in about 50 per cent of people with moderate or severe dementia. Indicators signify unmet need and can include restlessness, pacing, shouting or even verbal or physical aggression. The person with dementia may be in pain, hungry, thirsty, needing comfort or bored but unable to know or explain this.

The research team will develop, test and implement manuals to train staff about how best to reduce agitation and improve quality of life in care homes and for those people with dementia who are approaching the end of their lives. In addition, the team will mentor and train researchers to build capacity in dementia research.

LIASON PSYCHIATRY FOR OLDER PEOPLE
-The Behaviour and Pain (BepAid) Study
. The Impact of acute Hospitalisation on People with Dementia: -BUPA Foundation/Alzheimer's Society
-Dementia in the Acute Hospital.MRC funded fellowship to characterise epidemiology,outcomes, the impact of dementia and predictors of mortality
-Delirium: epidemiological studies in the acute hospital


Research Activities

End of life care in dementia: The implementation of an intervention

Pain and Impaired Cognition- EU Collaborative

Psychiatric and Supportive Care

Education Description

I teach on research methodology for the MSc in Psychiatric research

UCL Collaborators

Prof Gill Livingston; Dr Louise Jones; Prof Michael King; Dr Ingela Thune-Boyle

External Collaborators

Mrs Riitta Kukkastenvehmas; Dr Adrian Tookman

Publications

    2014

    • Elliot M, Harrington J, Moore K, Davis S, Kupeli N, Vickerstaff VH, Gola A, Candy B, Sampson EL, Jones L (2014). A protocol for an exploratory phase I mixed-methods study of enhanced integrated care for care home residents with advanced dementia: the Compassion Intervention. BMJ Open, , - . doi:10.1136/bmjopen-2014-005661
    • Perry J, Bell F, Shaw T, Fitzpatrick B, Sampson EL (2014). The use of PDSA methodology to evaluate and optimise an inner city memory clinic: a quality improvement project.. BMC Geriatr, 14, 4 - . doi:10.1186/1471-2318-14-4
    • Ritchie CW, Newman TH, Leurent B, Sampson EL (2014). The association between C-reactive protein and delirium in 710 acute elderly hospital admissions.. Int Psychogeriatr, , 1 - 8. doi:10.1017/S1041610213002433
    • Burbeck R, Low J, Sampson EL, Bravery R, Hill M, Morris S, Ockenden N, Payne S, Candy B (2014). Volunteers in Specialist Palliative Care: A Survey of Adult Services in the United Kingdom.. J Palliat Med, , - . doi:10.1089/jpm.2013.0157
    • Vickerstaff V, Sampson E, Scott S, Davis S, Lord K, Harrington J, Elliott M, Kupeli N, Jones L (2014). Satisfaction of carers of people with advanced dementia: their experiences at the of end of life.. BMJ Support Palliat Care, 4(1), 108 - . doi:10.1136/bmjspcare-2014-000653.9
    • Candy B, Elliott M, Jones L, Sampson E (2014). The evidence base of quality statements on advanced dementia: a systematic review.. BMJ Support Palliat Care, 4(1), 107 - . doi:10.1136/bmjspcare-2014-000653.6
    • Ahmed S, Leurent B, Sampson EL (2014). Risk factors for incident delirium among older people in acute hospital medical units: a systematic review and meta-analysis.. Age Ageing, , - . doi:10.1093/ageing/afu022
    • Round J, Sampson EL, Jones L (2014). A framework for understanding quality of life in individuals without capacity. Quality of Life Research, 23(2), 477 - 484. doi:10.1007/s11136-013-0500-z
    • Oosterman JM, Hendriks H, Scott S, Lord K, White N, Sampson EL (2014). When pain memories are lost: A pilot study of semantic knowledge of pain in dementia. Pain Medicine (United States), 15(5), 751 - 757. doi:10.1111/pme.12336
    • Sampson EL, White N, Leurent B, Scott S, Lord K, Round J, Jones L (2014). Behavioural and psychiatric symptoms in people with dementia admitted to the acute hospital: prospective cohort study.. Br J Psychiatry, , - . doi:10.1192/bjp.bp.113.130948

    2013

    • Burbeck R, Low J, Sampson EL, Scott R, Bravery R, Candy B (2013). Volunteer activity in specialist paediatric palliative care: a national survey. BMJ Supportive & Palliative Care, , - . doi:10.1136/bmjspcare-2012-000355
    • Livingston G, Barber J, Rapaport P, Knapp M, Griffin M, King D, Livingston D, Mummery C, Walker Z, Hoe J, Sampson EL, Cooper C (2013). Clinical effectiveness of a manual based coping strategy programme (START, STrAtegies for RelaTives) in promoting the mental health of carers of family members with dementia: pragmatic randomised controlled trial.. BMJ, 347, f6276 - .
    • Lord K, White N, Scott S, Sampson EL (2013). The behaviour and pain (bepaid) study: dementia patients who die in the acute hospital.. BMJ Support Palliat Care, 3(1), 124 - 125. doi:10.1136/bmjspcare-2013-000453a.2
    • Knapp M, King D, Romeo R, Schehl B, Barber J, Griffin M, Rapaport P, Livingston D, Mummery C, Walker Z, Hoe J, Sampson EL, Cooper C, Livingston G (2013). Cost effectiveness of a manual based coping strategy programme in promoting the mental health of family carers of people with dementia (the START (STrAtegies for RelaTives) study): a pragmatic randomised controlled trial.. BMJ, 347, f6342 - .
    • Chan D, Livingston G, Jones L, Sampson EL (2013). Grief reactions in dementia carers: a systematic review.. Int J Geriatr Psychiatry, 28(1), 1 - 17. doi:10.1002/gps.3795
    • Dening KH, Jones L, Sampson EL (2013). Preferences for end-of-life care: A nominal group study of people with dementia and their family carers. PALLIATIVE MEDICINE, 27(5), 409 - 417. doi:10.1177/0269216312464094
    • Abdulla A, Bone M, Adams N, Elliott AM, Jones D, Knaggs R, Martin D, Sampson EL, Schofield P (2013). Evidence-based clinical practice guidelines on management of pain in older people.. Age Ageing, 42(2), 151 - 153. doi:10.1093/ageing/afs199
    • Sampson EL, Burns A (2013). Planning a personalised future with dementia: 'the misleading simplicity of advance directives'.. Palliat Med, 27(5), 387 - 388. doi:10.1177/0269216313484426
    • Brown MA, Sampson EL, Jones L, Barron AM (2013). Prognostic indicators of 6-month mortality in elderly people with advanced dementia: A systematic review. PALLIATIVE MEDICINE, 27(5), 389 - 400. doi:10.1177/0269216312465649

    2012

    • Connolly A, Sampson EL, Purandare N (2012). End-of-life care for people with dementia from ethnic minority groups: a systematic review.. J Am Geriatr Soc, 60(2), 351 - 360. doi:10.1111/j.1532-5415.2011.03754.x
    • Sampson EL, Leurent B, Jones L, Blanchard MR, King M (2012). Survival of people with dementia after unplanned acute hospital admission: A prospective cohort study. International Journal of Geriatric Psychiatry, , - . doi:10.1002/gps.3919
    • Jones L, Harrington J, Scott S, Davis S, Lord K, Vickerstaff V, Round J, Candy B, Sampson EL (2012). CoMPASs:IOn programme (Care of Memory Problems in Advanced Stages of dementia: Improving our Knowledge); protocol for a mixed methods study. BMJ Open, 2(6), - . doi:10.1136/bmjopen-2012-002265
    • Sampson EL (2012). Frailty and dementia: common but complex comorbidities.. Aging Ment Health, 16(3), 269 - 272. doi:10.1080/13607863.2012.657158
    • Sampson EL, Jenagaratnam L, McShane R (2012). Metal protein attenuating compounds for the treatment of Alzheimer's dementia.. Cochrane database of systematic reviews (Online), 5, - .
    • Scott S, Sampson EL, Jones L (2012). The Compassion programme: looking at improving end-of-life care for people with advanced dementia. International Journal Palliative Nursing, 18(5), 212 - 216.
    • Watkin L, Blanchard MR, Tookman A, Sampson EL (2012). Prospective cohort study of adverse events in older people admitted to the acute general hospital: Risk factors and the impact of dementia. International Journal of Geriatric Psychiatry, 27(1), 76 - 82. doi:10.1002/gps.2693

    2011

    • Mukadam N, Sampson EL (2011). A systematic review of the prevalence, associations and outcomes of dementia in older general hospital inpatients. International Psychogeriatrics, 23(3), 344 - 355. doi:10.1017/S1041610210001717
    • Sampson EL, Burns A, Richards M (2011). Improving end-of-life care for people with dementia.. Br J Psychiatry, 199(5), 357 - 359. doi:10.1192/bjp.bp.111.097030
    • Sampson EL (2011). A rapid participatory appraisal to improve end-of-life care for people with dementia: A whole-community study. INTERNATIONAL PSYCHOGERIATRICS, 23, S25 - S26.
    • Scott S, Jones L, Blanchard MR, Sampson EL (2011). Study protocol: the behaviour and pain in dementia study (BePAID).. BMC Geriatr, 11, 61 - . doi:10.1186/1471-2318-11-61
    • Dening KH, Jones L, Sampson EL (2011). Advance care planning for people with dementia: a review.. Int Psychogeriatr, 23(10), 1535 - 1551. doi:10.1017/S1041610211001608
    • Sampson EL, Harrison Dening K (2011). Palliative care and end of life care. In Dening T, Milne A (Ed.), Mental Health and Care Homes (pp. - ). : Oxford University Press.
    • Sampson EL, Jones L, Thuné-Boyle IC, Kukkastenvehmas R, King M, Leurent B, Tookman A, Blanchard MR (2011). Palliative assessment and advance care planning in severe dementia: an exploratory randomized controlled trial of a complex intervention.. Palliat Med, 25(3), 197 - 209. doi:10.1177/0269216310391691

    2010

    • Sampson EL (2010). Hospital admissions in dementia. In Hughes J, Lloyd-Williams M, Sachs G (Ed.), Supportive Care for the Person with Dementia (pp. - ). : Oxford Univ Pr.
    • Collins N, Blanchard MR, Tookman A, Sampson EL (2010). Detection of delirium in the acute hospital. Age and Ageing, 39(1), 131 - 135.
    • Sampson EL (2010). Palliative care for people with dementia. British Medical Bulletin, , - .
    • Goodman C, Evans C, Wilcock J, Froggatt K, Sampson EL, Drennan V, Blanchard M, Bissett M, Iliffe S (2010). End of life care for community dwelling older people with dementia: an integrated review. International Journal of Geriatric Psychiatry, 25(4), 329 - 337.
    • Thuné-Boyle ICV, King M, Blanchard MR, Sampson EL, Jones L, Lee DR (2010). Challenges to improving end of life care of people with advanced dementia in the UK. Dementia, 9(2), 259 - 284. doi:10.1177/1471301209354026
    • Livingston G, Leavey G, Manela M, Livingston D, Rait G, Sampson E, Bavishi S, Shahriyarmolki K, Cooper C (2010). Making decisions for people with dementia who lack capacity: qualitative study of family carers in UK.. BMJ, 341, c4184 - .

    2009

    • Sampson EL, Blanchard MR, Jones L, Tookman A, King M (2009). Dementia in the acute hospital: prospective cohort study of prevalence and mortality. British Journal of Psychiatry, 195(1), 61 - 66.
    • Sampson EL, Harrison-Dening K, Greenish W, Mandal U, Holman A, Jones L (2009). End of life care for people with dementia.
    • Sampson EL, Robinson L (2009). End of life care in dementia: Building bridges for effective multidisciplinary care. Dementia: The International Journal of Social Research and Practice, 8, 331 - 334.
    • Robinson L, Sampson E, L (2009). End of life care in dementia: Research needed urgently to determine the acceptability and effectiveness of innovative approaches. Dementia: The International Journal of Social Research and Practice, 8, 417 - 419.
    • Sampson EL, Candy B, Jones L (2009). Enteral tube feeding for older people with advanced dementia. Cochrane Database of Systematic Reviews, (2), CD007209 - . doi:10.1002/14651858.CD007209.pub2
    • Sampson EL, Candy B, Jones L (2009). Enteral tube feeding for older people with advanced dementia.. Cochrane database of systematic reviews (Online), (2), - .
    • Candy B, Sampson EL, Jones , L (2009). Enteral tube feeding in older people with advanced dementia: Findings from a Cochrane systematic review. International Journal of Palliative Nursing, 15(8), 396 - 404.
    • Sampson EL, Bulpitt CJ, Fletcher AE (2009). Survival of community-dwelling older people: The effect of cognitive impairment and social engagement. Journal of the American Geriatrics Society, 57(6), 985 - 991.

    2008

    • Namnyak M, Tufton N, Szekely R, Toal M, Worboys S, Sampson EL (2008). Stockholm Syndrome: psychiatric diagnosis or urban myth?. Acta Psychiatrica Scandinavica, 117(1), 4 - 11. doi:10.1111/j.1600-0447.2007.01112.x
    • McShane R, Jenagaratnam L, Sampson EL (2008). Metal Protein Attenuating Compounds (MPACs) for the Treatment of Alzheimer's Disease. Cochrane Database of Systematic Reviews, 1, - .
    • Jolley D, Hughes J, Greaves I, Jordan A, Sampson EL (2008). Seeing patients with dementia through to the end of life. Geriatric Medicine, (Sept), 461 - 464.
    • Sampson EL, Simard M (2008). Cholinesterase inhibitors for the treatment of dementia. In Tyrer P, Silk K (Ed.), Cambridge Handbook of Effective Treatments in Psychiatry (pp. 217 - 243). : Cambridge University Press.
    • Dartington T, Coupe K, Malloy L, Brennan M, Sampson EL (2008). Dying from dementia - a patient’s journey. British Medical Journal, 337:a1712, - .
    • Sampson E, Thuné-Boyle I, Kukkastenvehmas R, Jones L, Tookman A, King M, Blanchard M (2008). Palliative care in advanced dementia:a mixed methods approach for the development of a complex intervention. BMC Palliative Care, 7, - .
    • Bourne RS, Borthwick M, Sampson EL (2008). Drug treatment of delirium:Past,present and future. Journal of Psychosomatic Research, 65(3), 273 - 282.
    • Mukadam N, Ritchie CW, Sampson EL (2008). Cholinesterase inhibitors for delirium: what is the evidence?. International Psychogeriatrics, 20(2), 209 - 218. doi:10.1017/S1041610207006205

    2007

    • Sampson EL, Dover D, Mandell M, Pant A, Blanchard MR (2007). Personal identification (PIN) numbers: a new cause of financial exclusion in older people.. International Journal of Geriatric Psychiatry, 22(5), 492 - 493. doi:10.1002/gps.1708
    • Whitwell JL, Sampson EL, Loy CT, Warren JE, Rossor MN, Fox NC, Warren JD (2007). VBM signatures of abnormal eating behaviours in frontotemporal lobar degeneration. NeuroImage, 35(1), 207 - 213. doi:10.1016/j.neuroimage.2006.12.006
    • Sampson EL, Raven PR, Ndhlovu PN, Vallance A, Garlick N, Watts J, Blanchard MR, Bruce A, Blizard R, Ritchie CW (2007). A randomized, double-blind, placebo-controlled trial of donepezil hydrochloride (Aricept) for reducing the incidence of postoperative delirium after elective total hip replacement.. International Journal of Geriatric Psychiatry, 22(4), 343 - 349. doi:10.1002/gps.1679
    • Hughes JC, Jolley D, Jordan A, Sampson EL (2007). Palliative care in dementia: issues and evidence. Advances in Psychiatric Treatment, 13, 251 - 260.

    2006

    • Sampson EL, Warren JD, Rossor MN (2006). Young onset dementia. In Morris H (Ed.), Neurology update: reviews for continuing professional development (pp. 215 - 248). : Radcliffe Publishing.
    • Sampson EL (2006). Differences in end of life care in patients who died with dementia during acute hospital admissions - Reply. AGE AGEING, 35(4), 452 - 452. doi:10.1093/ageing/afl035
    • Sampson E (2006). Counselling older people: A systematic review. BRIT J PSYCHIAT, 188, 589 - 590.
    • Sampson EL, Gould V, Lee D, Blanchard MR (2006). Differences in care received by patients with and without dementia who died during acute hospital admission: a retrospective case note study. Age and Ageing, 35(2), 187 - 189. doi:10.1093/ageing/afj025

    2005

    • Sampson EL, Ritchie CW, Lai R, Raven PW, Blanchard MR (2005). A systematic review of the scientific evidence for the efficacy of a palliative care approach in advanced dementia. International Psychogeriatrics, 17(1), 31 - 40. doi:10.1017/S1041610205001018
    • Whitwell JL, Sampson EL, Watt HC, Harvey RJ, Rossor MN, Fox NC (2005). A volumetric magnetic resonance imaging study of the amygdala in frontotemporal lobar degeneration and Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 20(4), 238 - 244. doi:10.1159/000087343
    • Sampson EL (2005). Psychiatry. In Kalra PA (Ed.), Essential Revision Notes for MRCP (pp. 611 - 640). : Pastest.

    2004

    • Sampson E, Harvey R (2004). Measures of severity and functional ability in FTD.
    • Cagnin A, Rosser M, Sampson EL, MacKinnon T, Banati RB (2004). In vivo detection of microglial activation in frontotemporal dementia. Annals of Neurology, 56(6), 894 - 897.
    • Sampson E, Mukherjee S, Ukoumunne OC, Mullan N, Bullock T (2004). History of deliberate self-harm and its association with mood fluctuation.. J Affect Disord, 79(1-3), 223 - 227. doi:10.1016/S0165-0327(02)00337-3
    • Chan D, Walters RJ, Sampson EL, Schott JM, Smith SJ, Rossor MN (2004). EEG abnormalities in frontotemporal lobar degeneration. Neurology, 62(9), 1628 - 1630.
    • Bashir N, Ahmed N, Singh A, Zhi Tang Y, Young M, Abba A, Sampson EL (2004). A precious case from Middle Earth. BMJ (Clinical Research Ed.), 329, 1435 - 1436.
    • Sampson EL, Warren JD, Rossor MN (2004). Young onset dementia. Postgraduate Medical Journal, 80(941), 125 - 139. doi:10.1136/pgmj.2003.011171

    2003

    • Ritchie CW, Sampson E (2003). How to treat confusion in the elderly. Health and Ageing, 12, 18 - 21.
    • Pijnenburg YAL, Sampson EL, Harvey RJ, Fox NC, Rossor MN (2003). Vulnerability to neuroleptic side effects in frontotemporal lobar degeneration. International Journal of Geriatric Psychiatry, 18(1), 67 - 72.
    • Chan D, Anderson V, Sampson EL, Scahill RI, Whitwell JL, Stevens JM, Fox NC, Rossor MN (2003). The clinical and behavioural correlates of right temporal lobe atrophy.

    2002

    • Sampson EL, Whitwell J, Fox NC (2002). Aggressive behaviour in frontotemporal lobar degeneration. Neurobiology of Aging, 23, S133 - .
    • Whitwell J, Sampson E, Fox NC (2002). A volumetric MRI analysis of the amygdala in Alzheimer's disease and frontotemporal lobar degeneration. Neurobiology of Aging, 23, S354 - .

    2001

    • Sampson E (2001). Practising evidence-based mental health. BRIT J PSYCHIAT, 178, 288 - 288.

    2000

    • Sampson E, Conran J, Harvey RJ (2000). Understanding and managing fronto-temporal dementia. CPD Bulletin Old Age Psychiatry, 2(2), 31 - 36.

    1999

    • Sampson E, Warner JP (1999). Serotonin syndrome: potentially fatal but difficult to recognize.. British Journal of General Practice, 49(448), 867 - 868.

    1998

    • Sikdar S, Ayonrinde O, Sampson E (1998). Physical dependence on zopiclone (multiple letters) [3]. British Medical Journal, 317(7151), 146 - 146.
    • Ayonrinde O, Sampson E (1998). Physical dependence on zopiclone. Risk of dependence may be greater in those with dependent personalities.. BMJ, 317(7151), 146 - .

    • Sampson EL, Mandal U, Holman A, Greenish W, Harrison-Dening K, Jones L (). Improving end of life care for people with dementia: a rapid participatory appraisal. BMJ Supportive and Palliative Care, 2012, - . doi:10.1136/bmjspcare-2011-000177
    • Harrison-Dening K, Greenish W, Jones L, Mandal U, Sampson EL (). Barriers to providing end-of-life care for people with dementia: a whole-system qualitative study. BMJ Supportive and Palliative Care, 2012, - . doi:10.1136/bmjspcare-2011-000178