Dr Mahdad Noursadeghi

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Personal Profile

Name: Mahdad Noursadeghi Email: m.noursadeghi@ucl.ac.uk
Title: Dr Tel: 02031082128
Department: Div of Infection & Immunity Fax: 08701305270
Position: Clinical Research Fellow Address: Infection & Immunity, Cruciform Building, Gower Street, London, WC1E 6BT
Research Domain: Experimental Medicine, Global Health, Infection, Immunology & Inflammation, Personalised Medicine Web Page: Personal Web Page

Profile

Research Description

My group investigate host-pathogen interactions in order to increase our mechanistic understanding of protective and pathogenic immune responses in infectious diseases, and inform the development of novel therapies or approaches for patient stratification. We particularly focus on innate immunity by modelling host-pathogen interactions in human macrophages. Although macrophages are important sentinels of the immune system, which can sense and respond to danger, restrict pathogens by intracellular killing pathways and regulate wide-ranging immune responses, they also host a number of important human pathogens such as HIV-1 and Mycobacterium tuberculosis. Hence we are interested in the mechanisms by which these pathogens can either evade host defence mechanisms in macrophages or stimulate harmful immune responses. Our work extends from in vitro laboratory models to challenge experiments in humans and sampling of tissues at the site of disease in order to understand host-pathogen interactions in vivo. In view of the multivariate complexity of the immune response in infectious diseases, we use genome‑wide transcriptional profiling strategies in order to obtain a systems level view together with detailed molecular resolution. Within the Division of Infection & Immunity at UCL, we work closely with Professor Benny Chain’s group who focus on developing computational approaches to interrogate high dimensional data in immunology.


Research Activities

Antigen processing and presentation

Innate Immunity

Macrophages & HIV-1 infection

Microorganisms and immunoregulation

Education Description

I am programme director for the intercalated BSc in Immunology and Cell Pathology. I also teach within the MSc programme in Infection and Immunity, Phase 2 Medicine lecture programme and within the UCL MB/PhD programme.

UCL Collaborators

Prof Benny Chain; Prof Ali Zumla; Prof Timothy Mchugh; Prof David Katz; Prof Greg Towers

External Collaborators

Publications

    2014

    • Kim S, Becker J, Bechheim M, Kaiser V, Noursadeghi M, Fricker N, Beier E, Klaschik S, Boor P, Hess T, Hofmann A, Holdenrieder S, Wendland JR, Fröhlich H, Hartmann G, Nöthen MM, Müller-Myhsok B, Pütz B, Hornung V, Schumacher J (2014). Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes.. Nat Commun, 5, 5236 - . doi:10.1038/ncomms6236
    • Tomlinson G, Chimalapati S, Pollard T, Lapp T, Cohen J, Camberlein E, Stafford S, Periselneris J, Aldridge C, Vollmer W, Picard C, Casanova JL, Noursadeghi M, Brown J (2014). TLR-Mediated Inflammatory Responses to Streptococcus pneumoniae Are Highly Dependent on Surface Expression of Bacterial Lipoproteins.. J Immunol, , - . doi:10.4049/jimmunol.1401413
    • Kundu R, Chain BM, Coussens AK, Khoo B, Noursadeghi M (2014). Regulation of CYP27B1 and CYP24A1 hydroxylases limits cell-autonomous activation of vitamin D in dendritic cells.. Eur J Immunol, , - . doi:10.1002/eji.201344157
    • Mlcochova P, Watters SA, Towers GJ, Noursadeghi M, Gupta RK (2014). Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages.. Retrovirology, 11(1), 25 - . doi:10.1186/1742-4690-11-25
    • Towers GJ, Noursadeghi M (2014). Interactions between HIV-1 and the Cell-Autonomous Innate Immune System.. Cell Host Microbe, 16(1), 10 - 18. doi:10.1016/j.chom.2014.06.009

    2013

    • Gil E, Noursadeghi M, Brown JS (2013). The clinical and ecological impact of childhood pneumococcal vaccination.. Br J Hosp Med (Lond), 74(4), 212 - 216.
    • Thomas N, Heather J, Pollara G, Simpson N, Matjeka T, Noursadeghi M, Chain B, Shawe-Taylor J (2013). The immune system as a biomonitor: Explorations in innate and adaptive immunity. Interface Focus, 3(2), - . doi:10.1098/rsfs.2012.0099
    • Hyams C, Trzcinski K, Camberlein E, Weinberger DM, Chimalapati S, Noursadeghi M, Lipsitch M, Brown JS (2013). Streptococcus pneumoniae capsular serotype invasiveness correlates with the degree of factor H binding and opsonization with C3b/iC3b.. Infect Immun, 81(1), 354 - 363. doi:10.1128/IAI.00862-12
    • Tomlinson GS, Hardavella G, Brown J, Succony L, Navani N, Thomas N, Chain BM, Janes SM, Noursadeghi M (2013). DIFFERENTIATION OF TUBERCULOSIS AND SARCOIDOSIS BY TRANSCRIPTIONAL PROFILING OF IMMUNE RESPONSES IN MEDIASTINAL LYMPH NODE SAMPLES. doi:10.1136/thoraxjnl-2013-204457.43
    • Tomlinson GS, Bell LC, Walker NF, Tsang J, Brown JS, Breen R, Lipman M, Katz DR, Miller RF, Chain BM, Elkington PT, Noursadeghi M (2013). HIV-1 infection of macrophages dysregulates innate immune responses to Mycobacterium tuberculosis by inhibition of interleukin 10.. J Infect Dis, , - . doi:10.1093/infdis/jit621
    • Rasaiyaah J, Tan CP, Fletcher AJ, Price AJ, Blondeau C, Hilditch L, Jacques DA, Selwood DL, James LC, Noursadeghi M, Towers GJ (2013). HIV-1 evades innate immune recognition through specific cofactor recruitment.. Nature, , - . doi:10.1038/nature12769
    • Marks M, Pollock E, Armstrong M, Morris-Jones S, Kidd M, Gothard P, Noursadeghi M, Doherty JF (2013). Needles and the damage done: reasons for admission and financial costs associated with injecting drug use in a Central London Teaching Hospital.. J Infect, 66(1), 95 - 102. doi:10.1016/j.jinf.2012.10.004

    2012

    • Matjeka T, Summerfield V, Noursadeghi M, Chain BM (2012). Chemical toxicity to keratinocytes triggers dendritic cell activation via an IL-1α path.. J Allergy Clin Immunol, 129(1), 247-50.e1-3 - . doi:10.1016/j.jaci.2011.08.018
    • Sayer RA, Cartledge JD, Whitehorn J, Shipley M, Noursadeghi M (2012). An unusual cause of fever in an HIV-positive patient. International Journal of STD and AIDS, 23(6), 453 - 454. doi:10.1258/ijsa.2009.009375
    • Tomlinson GS, Booth H, Petit SJ, Potton E, Towers GJ, Miller RF, Chain BM, Noursadesghi M (2012). Adherent human alveolar macrophages exhibit a transient pro-inflammatory profile that confounds responses to innate immune stimulation. PLoS One, 7, - .
    • Hughes R, Towers G, Noursadeghi M (2012). Innate immune interferon responses to human immunodeficiency virus-1 infection.. Rev Med Virol, 22(4), 257 - 266. doi:10.1002/rmv.1708
    • Guiliano DB, Lenart I, Evans R, Iwawaki T, Acord J, Noursadeghi M, Nesbeth D, Campbell EC, Gould K, Powis SJ, Antoniou AN (2012). HLA-B27 MISFOLDING AND CELLULAR STRESS INFLUENCE THE LIFECYCLE OF INFECTING SALMONELLA? A POTENTIAL MECHANISM FOR SALMONELLA SURVIVAL IN REACTIVE ARTHRITIS PATIENTS?. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 30(4), 637 - 637.

    2011

    • Evans R, Coussens AK, Kriston-Vizi J, Chain BJ, Noursadeghi M (2011). The effect of vitamin D on monocyte biology: a physiological perspective.
    • Sayer R, Paul J, Tuke PW, Hargreaves S, Noursadeghi M, Tedder RS, Grant P, Edwards SG, Miller RF (2011). Can plasma HHV8 viral load be used to differentiate multicentric Castleman disease from Kaposi sarcoma?. Int J STD AIDS, 22(10), 585 - 589. doi:10.1258/ijsa.2011.010464
    • Le Bert N, Chain BM, Rook G, Noursadeghi M (2011). DC priming by M. vaccae inhibits Th2 responses in contrast to specific TLR2 priming and is associated with selective activation of the CREB pathway.. PLoS One, 6(4), e18346 - . doi:10.1371/journal.pone.0018346
    • Shimizu A, Baratchian M, Takeuchi Y, Escors D, Macdonald D, Barrett T, Bagneris C, Collins M, Noursadeghi M (2011). Kaposi's sarcoma-associated herpesvirus vFLIP and human T cell lymphotropic virus type 1 Tax oncogenic proteins activate IkappaB kinase subunit gamma by different mechanisms independent of the physiological cytokine-induced pathways.. J Virol, 85(14), 7444 - 7448. doi:10.1128/JVI.02337-10
    • Tomlinson GS, Cashmore TJ, Elkington PT, Yates J, Lehloenya RJ, Tsang J, Brown M, Miller RF, Dheda K, Katz DR, Chain BM, Noursadeghi M (2011). Transcriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test.. Eur J Immunol, 41(11), 3253 - 3260. doi:10.1002/eji.201141841
    • Schaller T, Ocwieja KE, Rasaiyaah J, Price AJ, Brady TL, Roth SL, Hué S, Fletcher AJ, Lee K, KewalRamani VN, Noursadeghi M, Jenner RG, James LC, Bushman FD, Towers GJ (2011). HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency.. PLoS Pathog, 7(12), e1002439 - . doi:10.1371/journal.ppat.1002439
    • Tomlinson GS, Elkington PTG, Bell L, Walker NF, Tsang J, Brown J, Breen R, Lipman M, Katz DR, Miller RF, Chain BM, Noursadeghi M (2011). HIV-1 INFECTION OF MACROPHAGES DYSREGULATES PRO-INFLAMMATORY HOST RESPONSES TO MYCOBACTERIUM TUBERCULOSIS THROUGH INHIBITION OF INTERLEUKIN 10. doi:10.1136/thoraxjnl-2011-201054b.130

    2010

    • Sage EK, Noursadeghi M, Evans HE, Parker SJ, Copas AJ, Edwards SG, Miller RF (2010). Prognostic value of C-reactive protein in HIV-infected patients with Pneumocystis jirovecii pneumonia.. Int J STD AIDS, 21(4), 288 - 292. doi:10.1258/ijsa.2010.009551
    • Paris M, Jagger A, Noursadeghi M, Akbar A, Taams L (2010). Modulation of human monocyte function by effector and regulatory CD4(+) T cells.
    • Chain B, Bowen H, Hammond J, Posch W, Rasaiyaah J, Tsang J, Noursadeghi M (2010). Error, reproducibility and sensitivity: a pipeline for data processing of Agilent oligonucleotide expression arrays.. BMC Bioinformatics, 11, 344 - . doi:10.1186/1471-2105-11-344
    • Raiber EA, Tulone C, Zhang Y, Martinez-Pomares L, Steed E, Sponaas AM, Langhorne J, Noursadeghi M, Chain BM, Tabor AB (2010). Targeted delivery of antigen processing inhibitors to antigen presenting cells via mannose receptors.. ACS Chem Biol, 5(5), 461 - 476. doi:10.1021/cb100008p
    • Guiliano DB, Nesbeth D, Gould K, Noursadeghi M, Antoniou AN (2010). The folding status of HLA-B27 influences the outcome S. typhimurium infection.
    • Collini P, Noursadeghi M, Sabroe I, Miller RF, Dockrell DH (2010). Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunity.. Curr Mol Med, 10(8), 727 - 740.
    • Tomlinson GS, Elkington PTG, Miller RF, Chain BM, Brown J, Noursadeghi M (2010). Macrophage inflammatory responses in pulmonary infection.
    • Tomlinson GS, Khandavilli S, Cohen J, Hyams C, Brown J, Noursadeghi M (2010). DETERMINANTS OF MACROPHAGE RESPONSES TO STREPTOCOCCUS PNEUMONIAE. doi:10.1136/thx.2010.150938.29
    • Tomlinson S, Elkington PTG, Noursadeghi M (2010). HIV-1 INFECTION OF MACROPHAGES MODULATES HOST RESPONSES TO MYCOBACTERIUM TUBERCULOSIS TO CONTRIBUTE TO IMMUNOPATHOGENESIS AND VIRAL PROPAGATION. doi:10.1136/thx.2010.150912.1

    2009

    • Ylinen LM, Schaller T, Price A, Fletcher AJ, Noursadeghi M, James LC, Towers GJ (2009). Cyclophilin A levels dictate infection efficiency of Human Immunodeficiency Virus Type 1 Capsid Escape Mutants A92E and G94D. Journal of Virology, 83, 2044 - 2047.
    • Tsang J, Chain BM, Miller RF, Webb BL, Barclay W, Towers GJ, Katz DR, Noursadeghi M (2009). HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation. AIDS, 23(17), 2255 - 2263. doi:10.1097/QAD.0b013e328331a4ce
    • Sage EK, Evans HE, Noursadeghi M, Edwards SG, Miller RF (2009). Prognostic Value of C-Reactive Protein in Pneumocystis Pneumonia.. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 179, - .
    • Hyams CJ, Camberlein E, Noursadeghi M, Weiser JN, Brown JS (2009). THE STREPTOCOCCUS PNEUMONIAE CAPSULE INHIBITS MACROPHAGE ACTIVATION THROUGH THE NF-KB AND NOT MAPK ACTIVATION PATHWAYS. doi:10.1136/thx.2009.127076m
    • Rasaiyaah J, Noursadeghi M, Kellam PACBM (2009). Transcriptional and functional defects of dendritic cells derived from the MUTZ-3 leukaemia line.. Immunology, , - .
    • Noursadeghi M, Tsang J, Miller RF, Straschewski S, Kellam P, Chain BM, Katz DR (2009). Genome wide innate immune responses in HIV 1 infected macrophages are preserved despite attenuation of the NF-κappa B activation pathway.. The Journal of Immunology, 182(1), 319 - 328.

    2008

    • Hyams CJ, Camberlein EM, Yuste J, Noursadeghi M, Michael C, Weiser JN, Brown JS (2008). THE STREPTOCOCCUS PNEUMONIAE CAPSULE IS ESSENTIAL FOR EVASION OF ALVEOLAR MACROPHAGE-MEDIATED PULMONARY IMMUNITY.
    • Tsang J, Chain B, Miller R, Katz D, Noursadeghi M (2008). HIV-1 INFECTION CAN INFECT AND REPLICATE IN HUMAN MACROPHAGES UNDETECTED BY THE HOST INNATE IMMUNE SYSTEM. J INFECTION, 57(5), 430 - 430.
    • Noursadeghi M, Tsang J, Miller R, Katz D (2008). Studying the effect of HIV infection in human macrophages. J INFECTION, 56(4), 298 - 299.
    • Efklidou S, Bailey R, Field N, Noursadeghi M, Collins MK (2008). vFLIP from KSHV inhibits anoikis of primary endothelial cells. Journal of Cell Science, 121, 450 - 457.
    • Noursadeghi M, Tsang J, Miller RF, Katz DR (2008). Comment on "Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages".. J Immunol, 180(12), 7783 - .
    • Chain B, M N, M G, M T, J W, E (2008). HIV blocking antibodies following immunisation with chimaeric peptides coding a short N-terminal sequence of the CCR5 receptor.. Vaccine, , - . doi:10.1016/j.vaccine.2008.08.025
    • Noursadeghi M, Tsang J, Haustein T, Miller RF, Chain BM, Katz DR (2008). Quantitative imaging assay for NF-kappaB nuclear translocation in primary human macrophages.. Journal of Immunological Methods, 329(1), 194 - 200.

    2007

    • Ng SC, Noursadeghi M, von Herbay A, Vaizey C, Pitcher MC, Flanagan KL (2007). Cytomegalovirus ileitis associated with goblet cell carcinoid tumour of the appendix.. Journal of Infection, 54(3), e153 - e156.

    2006

    • Noursadeghi M, Aqel N, Gibson P, Pasvol G (2006). Successful treatment of severe Kikuchi's disease with intravenous immunoglobulin. Rheumatology, 45(2), 235 - 237.
    • Noursadeghi M, Aqel N, Pasvol G (2006). Reply to angel-moreno et Al. Clinical Infectious Diseases, 42(4), 579 - 580.
    • Noursadeghi M, Katz DR, Miller RF (2006). HIV-1 infection of mononuclear phagocytic cells: the case for bacterial innate immune deficiency in AIDS.. The Lancet Infectious Diseases, 6(12), 794 - 804.
    • Tuladhar SM, Noursadeghi M, Boyle JJ, Friedland JS, Hornick P (2006). Tuberculous pericardial effusion after coronary artery bypass graft.. The Annals of Thoracic Surgery, 82(4), 1519 - 1521.
    • Noursadeghi M, Aqel N, Pasvol G (2006). Kikuchi's disease or Kikuchi's syndrome? Reply. CLIN INFECT DIS, 42(4), 579 - 580.
    • Noursadeghi M, Ustianowski A, Elgalib A, Miller RF (2006). Bacterial disease in HIV-infected patients: the blind spot of highly active antiretroviral therapy?. JAIDS: Journal of Acquired Immune Deficiency Syndromes, 41(4), 532 - 535.

    2005

    • Bacon CM, Miller RF, Noursadeghi M, McNamara C, Du MQ, Dogan A (2005). Bone marrow pathology in Human Herpes Virus 8 (HHV8)-associated multicentric Castleman disease.
    • Bacon CM, Miller RF, Noursadeghi M, McNamara C, Du MQ, Dogan A (2005). Bone marrow pathology in human herpes virus 8 (HHV8) - Associated multicentric Castleman disease.
    • Brown M, Noursadeghi M, Boyle J, Davidson RN (2005). Successful liposomal amphotericin B treatment of Leishmania braziliensis cutaneous leishmaniasis. British Journal of Dermatology, 153(1), 203 - 205.
    • Dave SS, Noursadeghi M, Rickards D, Cartledge JD, Miller RF (2005). Atypical presentation of lobar nephronia in an adult co-infected with HIV and hepatitis C. Sexually Transmitted Infections, 81(2), 183 - .
    • Noursadeghi M, Pepys MB, Gallimore R, Cohen J (2005). Relationship of granulocyte colony stimulating factor with other acute phase reactants in man. Clin Exp Immunol, 140(1), 97 - 100.
    • Noursadeghi M, Miller RF (2005). Clinical value of C-reactive protein measurements in HIV positive patients.. International Journal of STD and AIDS, 16, 438 - 441.
    • Noursadeghi M, Aqel N, Pasvol G (2005). Kikuchi's disease: a rare cause of meningitis?. Clinical Infectious Diseases, 41(8), E80 - E82.
    • Llewelyn MJ, Noursadeghi M, Dogan A, Edwards SG, Miller RF (2005). Diagnostic utility of bone marrow sampling in HIV-infected patients since the advent of highly active antiretroviral therapy.. International Journal of STD and AIDS, , - .
    • Booth H, Noursadeghi M, Boparai N, Goodburn A, Scott G, Miller R (2005). Offering HIV tests in the tuberculosis clinic: Improving clinical practice using a continuous quality improvement programme.

    2004

    • Bacon CM, Miller RF, Noursadeghi M, mc Namara C, Du MQ, Dogan A (2004). Pathology of bone marrow in human herpes virus 8 (HHV8)-associated Multicentric Castleman's disease. British Journal of Haematology, 127, 585 - 591.
    • Noursadeghi M, Miller RF (2004). AIDS and the Lung. Medicine, 31, 134 - 139.
    • Bacon CM, Miller RF, Noursadeghi M, McNamara C, Du MQ, Dogan A (2004). Pathology of bone marrow in human Herpes virus 8 (HHV8) associated multicentric Castleman's disease..

    2003

    • Pearl D, Noursadeghi M, Manji H, Edwards S, Miller R (2003). Lower motor neuron syndrome and HIV infection. Sexually Transmitted Infections, 79, 351 - .

    2002

    • Noursadeghi M, Bickerstaff MCM, Herbert J, Moyes D, Cohen J, Pepys MB (2002). Production of granulocyte colony-stimulating factor in the nonspecific acute phase response enhances host resistance to bacterial infection. J Immunol, 169(2), 913 - 919.
    • Warren J, Mastroeni P, Dougan G, Noursadeghi M, Cohen J, Walport MJ, Botto M (2002). Increased susceptibility of C1q-deficient mice to Salmonella enterica serovar Typhimurium infection.. Infection and Immunity, 70(2), 551 - 557.

    2001

    • Salcedo SP, Noursadeghi M, Cohen J, Holden DW (2001). Intracellular replication of Salmonella typhimurium strains in specific subsets of splenic macrophages in vivo. Cellular Microbiology, 3, 587 - 597. doi:10.1046/j.1462-5822.2001.00137.x

    2000

    • Noursadeghi M, Cohen J (2000). Immunopathogenesis of severe sepsis.. Journal of the Royal College of Physicians of London, 34(5), 432 - 436.
    • Noursadeghi M, Bickerstaff MCM, Gallimore JR, Herbert J, Cohen J, Pepys MB (2000). Role of serum amyloid P component in bacterial infection: protection of the host or protection of the pathogen. Proc Natl Acad Sci U S A, 97(26), 14584 - 14589.

    1998

    • Hanna MG, Davis MB, Sweeney MG, Noursadeghi M, Ellis C, Elliott P, Wood NW (1998). Generalised chorea in two patients harbouring Friedrich's ataxia trinucleotide repeat expansion. Movement Disorders, 13, 339 - 340.

    1993

    • Noursadeghi M, Walsh FS, Heiman-Patterson T, Dickson G (1993). Trans-activation of the murine dystrophin gene in human-mouse hybrid myotubes.. FEBS Letters, 320(2), 155 - 159.

    1992

    • Dickson G, Azad A, Morris GE, Simon H, Noursadeghi M, Walsh FS (1992). Co-localization and molecular association of dystrophin with laminin at the surface of mouse and human myotubes.. Journal of Cell Science, 103(4), 1223 - 1233.

    • Evans , Coussens , Kriston-Vizi J, Chain , Noursadeghi (). The effect of vitamin D on monocyte biology: a physiological perspective.