Prof Sir Salvador Moncada

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Personal Profile

Name: Salvador Moncada Email: s.moncada@ucl.ac.uk
Title: Prof Sir Tel: 0207 679 6666
Department: Wolfson Inst for Biomedical Research Fax: 0207 209 0470
Position: Emeritus Professor of Biology and Therapeutics Address: Wolfson Institute for Biomedical Research, Cruxiform Building, Gower Street, London, WC1E 6BT
Research Domain: Cardiometabolic Science, Personalised Medicine Web Page:  

Profile

Research Description


Research Activities

critical care

Education Description

UCL Collaborators

Dr Geoffrey Bellingan; Prof Derek Gilroy; Prof Mervyn Singer; Prof Michael Duchen; Prof Lucie Clapp

External Collaborators

Publications

    2014

    • Funes JM, Henderson S, Kaufman R, Flanagan JM, Robson M, Pedley B, Moncada S, Boshoff C (2014). Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival.. Mol Cancer, 13(1), 20 - . doi:10.1186/1476-4598-13-20

    2013

    • Moncada S (2013). 1st Andres Laguna Master Lecture. Metabolism of cell division: Discovery and perspectives. REVISTA CLINICA ESPANOLA, 213(8), 399 - 402. doi:10.1016/j.rce.2013.06.004

    2012

    • Garedew A, Henderson SO, Moncada S (2012). Retraction: Activated macrophages utilize glycolytic ATP to maintain mitochondrial membrane potential and prevent apoptotic cell death.. Cell Death Differ, , - . doi:10.1038/cdd.2012.103
    • Moncada S, Liew FY (2012). Recombinant Migration Inhibitory Factor Induces Nitric Oxide Synthase in Murine Macrophages (Retraction of vol 150, pg 1908, 1993). JOURNAL OF IMMUNOLOGY, 189(6), 3260 - 3260. doi:10.4049/jimmunol.1290047
    • Moncada S, Higgs EA, Colombo SL (2012). Fulfilling the metabolic requirements for cell proliferation.. Biochem J, 446(1), 1 - 7. doi:10.1042/BJ20120427

    2011

    • Tudzarova S, Colombo SL, Stoeber K, Carcamo S, Williams GH, Moncada S (2011). Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate glycolysis during the cell cycle.. Proc Natl Acad Sci U S A, 108(13), 5278 - 5283. doi:10.1073/pnas.1102247108
    • Colombo SL, Palacios-Callender M, Frakich N, Carcamo S, Kovacs I, Tudzarova S, Moncada S (2011). Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells.. Proc Natl Acad Sci U S A, 108(52), 21069 - 21074. doi:10.1073/pnas.1117500108
    • Moncada S (2011). THE HARNESSING OF GLYCOLYSIS AND GLUTAMINOLYSIS FOR CELL PROLIFERATION. BASIC CLIN PHARMACOL, 109, 2 - 2.

    2010

    • Moncada S (2010). Mitochondria as pharmacological targets.. Br J Pharmacol, 160(2), 217 - 219. doi:10.1111/j.1476-5381.2010.00706.x
    • Moncada S (2010). Nitric oxide and mitochondrial Interactions: physiology and pathophysiology. doi:10.1016/j.niox.2010.05.006
    • Galkin A, Frakich N, Moncada S (2010). Role of conformational changes in mitochondrial complex I in the hypoxic response. doi:10.1016/j.bbabio.2010.04.192
    • Garedew A, Moncada S (2010). Mitochondria of activated macrophages utilize glycolytic ATP to maintain membrane potential and prevent apoptosis. doi:10.1016/j.bbabio.2010.04.383
    • Colombo SL, Palacios-Callender M, Frakich N, De Leon J, Schmitt CA, Boorn L, Davis N, Moncada S (2010). Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes.. Proc Natl Acad Sci U S A, 107(44), 18868 - 18873. doi:10.1073/pnas.1012362107
    • De Palma C, Falcone S, Pisoni S, Cipolat S, Panzeri C, Pambianco S, Pisconti A, Allevi R, Bassi MT, Cossu G, Pozzan T, Moncada S, Scorrano L, Brunelli S, Clementi E (2010). Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation. CELL DEATH DIFFER, 17(11), 1684 - 1696. doi:10.1038/cdd.2010.48
    • Unitt DC, Hollis VS, Palacios-Callender M, Frakich N, Moncada S (2010). Inactivation of nitric oxide by cytochrome c oxidase under steady-state oxygen conditions. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1797, 371 - 377. doi:10.1016/j.bbabio.2009.12.002

    2009

    • Herrero-Mendez A, Almeida A, Fernandez E, Maestre C, Moncada S, Bolanos JP (2009). The bioenergetic and antioxidant status of neurons is regulated by continuous degradation of the key enzyme phosphofructokinase-2.
    • Galkin A, Abramov AY, Frakich N, Duchen MR, Moncada S (2009). Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?. J Biol Chem, 284(52), 36055 - 36061. doi:10.1074/jbc.M109.054346
    • Herrero Mendez A, Almeida A, Fernández E, Maestre C, Moncada S, Bolaños J (2009). The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.. Nature Cell Biology, 11(6), 747 - 752.
    • Victor VM, Nuñez C, D'Ocόn P, Taylor CT, Esplugues JV, Moncada S (2009). Regulation of oxygen distribution in tissues by endothelial nitric oxide.. Circulation Research, 104, 1178 - 1183.
    • Taylor CT, Moncada S (2009). Nitric oxide, cytochrome c oxidase and the cellular response to hypoxia.. Arteriosclerosis, Thrombosis, and Vascular Biology, , - . doi:10.1161/ATVBAHA.108.181628
    • Bolaños JP, Almeida A, Moncada S (2009). Glycolysis: a bioenergetic or a survival pathway?. Trends in Biochemical Sciences, , - . doi:10.1016/j.tibs.2009.10.006
    • Almeida A, Bolaños JP, Moncada S (2009). E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation.. Proceedings of the National Academy of Sciences of the United States of America, , - . doi:10.1073/pnas.0913668107
    • Colombo SL, Moncada S (2009). AMPK1 regulates the antioxidant status of vascular endothelial cells. Biochemical Journal, 421(2), 163 - 169. doi:10.1042/BJ20090613

    2008

    • Lafuente N, Matesanz N, Azcutia V, Romacho T, Nevado J, Rodríguez-Mañaz L, Moncada S, Peiró C, Sánchez-Ferrer CF (2008). The deleterious effect of high concentrations of D-glucose requires pro-inflammatory preconditioning.. Journal of Hypertension, 26, 478 - 485.

    2007

    • Funes JM, Quintero M, Henderson S, Martinez D, Qureshi U, Westwood C, Clements MO, Bourboulia D, Pedley RB, Moncada S, others (2007). Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proceedings of the National Academy of Sciences, 104, 6223 - 6228.
    • Palacios-Callender M, Hollis V, Mitchison M, Frakich N, Unitt D, Moncada S (2007). Cytochrome c oxidase resgulations endogenousnitric oxide availability in respiring cells: A possible explanation for hypoxic vasodilation.. Proceedings of the National Academy of Sciences of the United States of America, 104, 18508 - 18513.
    • Nisoli E, Clementi E, Carruba MO, Moncada S (2007). Defective mitochondrial biogenesis: A hallmark of the high cardiovascular risk in the metabolic syndrome?. Circulation Research, 100, 795 - 806.
    • Galkin A, Higgs A, Moncada S (2007). Nitric oxide and hypoxia.. Essays Biochem, 43, 29 - 42. doi:10.1042/BSE0430029
    • Galkin A, Moncada S (2007). S-Nitrosation of mitochondrial complex I depends on its structural conformation. Journal of Biological Chemistry, 282(52), 37448 - 37453.
    • Diaz Hernandez JL, Moncada S, Bolaños JP, Almeida A (2007). Poly(ADP-ribose) polymerase-1 protects neurons against apoptosis induced by oxidative stress.. Cell Death and Differentiation, 14, 1211 - 1221.
    • Erusalimsky J, Moncada S (2007). Nitric oxide and mitochondrial signaling. From physiology to pathophysiology.. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(12), 2524 - 2531.
    • Galkin A, Higgs EA, Moncada S (2007). Nitric oxide and hypoxia. In: Essays in Biochemistry - Oxygen sensing and hypoxia-induced responses..
    • Palacios-Callender M, Hollis V, Frakich N, Mateo J, Moncada S (2007). Cytochrome c oxidase maintains mitochondrial respiration during partial inhibition by nitric oxide. Journal of Cell Science, 120, 160 - 165.

    2006

    • Quintero M, Brennan PA, Thomas GJ, Moncada S (2006). Nitric oxide is a factor in the stabilization of hypoxiay-inducible factor-1α in cancer: Role of free radical formation.. Cancer Research, 66, 770 - 774.
    • Moncada S, Higgs EA (2006). Nitric oxide and the vascular endothelium.. Handb Exp Pharmacol, (176 Pt 1), 213 - 254.
    • Quintero M, Colombo SL, Godfrey A, Moncada S (2006). Mitochondria as signaling organelles in the vascular endothelium.. Proceedings of the National Academy of Sciences of the United States of America, 103, 5379 - 5384. doi:10.1073/pnas.0601026103
    • Moncada S, Bolaños JP (2006). Nitric oxide, cell bioenergetics and neurodegeneration.. Journal of Neurochemistry, 97, 1676 - 1689.
    • Moncada S (2006). Adventures in vascular biology: a tale of two mediators.. Philosophical Transactions of the Royal Society B: Biological Sciences, 361(1469), 735 - 759.
    • Moncada S, Higgs EA (2006). Nitric oxide and the vascular endothelium.. In Moncada S, Higgs EA (Ed.), The Vascular Endothelium I (pp. 214 - 254). : Springer-Verlag.
    • Carré J, Singer M, Moncada S (2006). Nitric oxide.. In Abraham E, Singer M (Ed.), Mechanisms of sepsis-induced organ dysfunction and recovery (pp. 77 - 95). : Springer-Verlag.
    • Moncada S (2006). Sir John Robert Vane: 29 March 1927 - 19 November 2004.. Biogr Mem Fellows R Soc, 52, 401 - 411.
    • Valerio A, Cardile A, Cozzi V, Bracale R, Tedesco L, Pisconti A, Palomba L, Cantoni O, Clementi E, Moncada S, Carruba MO, Nisoli E (2006). TNF-α downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. Journal of Clinical Investigation, 116, 2791 - 2798.
    • Moncada S, Higgs EA (2006). The discovery of nitric oxide and its role in vascular biology.. British Journal of Pharmacology, 147(S1), S193 - S201.
    • D'Amico G, Lam F, Hagen T, Moncada S (2006). Inhibition of cellular respiration by endogenously produced carbon monoxide.. Journal of Cell Science, 119, 2291 - 2298.
    • Moncada S (2006). Sir John Robert Vane, a biographical memoir.. In (Ed.), Biographical Memoirs of Fellows of The Royal Society (pp. 401 - 411). : The Royal Society.

    2005

    • Núñez C, Víctor MV, Tur R, Alvarez-Barrientos A, Moncada S, Esplugues JV, D Ocón P (2005). Discrepancies between nitroglycerin and NO-releasing drugs on mitochondrial oxygen consumption, vasoactivity and the release of NO.. Circulation Research, (97), 1063 - 1069.
    • Scotland RS, Madhani M, Chauhan S, Moncada S, Andresen J, Nilsson H, Hobbs AJ, Ahluwalia A (2005). Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo.. Circulation, 111(6), 796 - 803. doi:10.1161/01.CIR.0000155238.70797.4E
    • Borutaite V, Moncada S, Brown GC (2005). Nitric oxide from inducible nitric oxide synthase sensitizes the inflamed aorta to hypoxic damage via respiratory inhibition. SHOCK, 23(4), 319 - 323. doi:10.1097/01.shk.0000156672.364369.2d
    • Herman AG, Moncada S (2005). Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis. EUR HEART J, 26(19), 1945 - 1955. doi:10.1093/eurheartj/ehi333
    • Frost MT, Wang Q, Moncada S, Singer M (2005). Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages.. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 288(2), R394 - R400.
    • Alderton WK, Angell ADR, Craig C, Dawson J, Garvey E, Moncada S, Monkhouse J, Rees D, Russell LJ, Russell RJ, Schwarz S, Waslidge N, Knowles RG (2005). GW274150 and GW273629 are potent and highly selective inhibitiors of inducible nitric oxide synthase in vitro and in vivo.. British Journal of Pharmacology, , - .
    • Herman AG, Moncada S (2005). Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis.. European Heart Journal, (26), 1949 - 1955.
    • Xu W, Charles IG, Moncada S (2005). Nitric Oxide: orchestrating hypoxia regulation through mitochondrial respiration and the endoplasmic reticulum stress response.. Cell Research, 15(1), 63 - 65. doi:10.1038/sj.cr.7290267
    • Mander P, Borutaite V, Moncada S, Brown GC (2005). Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death. doi:10.1002/jnr.20285
    • Scotland RS, Madhani M, Chauhan SD, Moncada S, Hobbs AJ, Ahluwalia A (2005). Investigation of vascular responses in endothelial nitric oxide synthase-cyclooxygenase-1 double-knockout mice. Circulation, 111, 796 - 803.
    • Moncada S (2005). Obituary: John R. Vane (1927-2004).. Nature, 433(7021), 28 - . doi:10.1038/433028a
    • Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L, Falcone S, Valerio A, Cantoni O, Clementi E, Moncada S, Carruba MO (2005). Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science, 310, 314 - 317.

    2004

    • Almeida A, Moncada S, Bolanos JP (2004). Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nature Cell Biology, 6(1), 45 - 51.
    • Nisoli E, Falcone S, Tonello C, Cozzi V, Palomba L, Fiorani M, Pisconti A, Brunelli S, Cardile A, Francolini M, Cantoni O, Carruba MO, Moncada S, Clementi E (2004). Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals. P NATL ACAD SCI USA, 101(47), 16507 - 16512. doi:10.1073/pnas.0405432101
    • Hagen T, D'Amico G, Quintero M, Palacios-Callender M, Hollis V, Lam F, Moncada S (2004). Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol.. Biochem Biophys Res Commun, 322(3), 923 - 929. doi:10.1016/j.bbrc.2004.07.204
    • Palacios-Callender M, Quintero M, Hollis VS, Springett RJ, Moncada S (2004). Endogenous NO reulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase. Proceedings of the National Academy of Sciences of the United States of America, 101, 7630 - 7635.
    • Moncada S (2004). Adventures in pharmacology, aspirin, prostacyclin and nitric oxide.. Acta Cardiologica, 59(Suppl.1), 47 - 50.
    • Ahluwalia A, Foster P, Scotland R, McLean PG, Mathur A, Perretti M, Moncada S, Hobbs AJ (2004). Antiinflamatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocytes recruitment.. Proceedings of the National Academy of Sciences of the United States of America, 101(5), 1386 - 1391.
    • Hagen T, D'Amico G, Quintero M, Palacios-Callender M, Hollis VS, Lam F, Moncada S (2004). Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol. Biochemical and Biophysical Research Communications, 322, 923-929 - .
    • Nisoli E, Clementi E, Moncada S, Carruba MO (2004). Mitochondrial biogenesis as a cellular signalling framework. Biochemical Pharmacology, 67, 1 - 15.
    • Xu W, Liu L, Charles IG, Moncada S (2004). Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response. Nature Cell Biology, 6, 1129 - 1134. doi:10.1038/ncb1188
    • Cellek S, Qu W, Schmidt AM, Moncada S (2004). Synergistic action of advanced glycation end products and endogenous nitric oxide leads to neuronal apoptosis in vitro: A new insight into selective nitrergic neuropathy in diabetes. Diabetologia, 47, 331 - 339.

    2003

    • Hagen T, Taylor CT, Lam F, Moncada S (2003). Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1alpha. Science, 302, 1975 - 1978. doi:10.1126/science.1088805
    • Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonello C, Sciorati C, Bracale R, Valerio A, Francolini M, Moncada S, Carruba MO (2003). Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science, 299, 896 - 899. doi:10.1126/science.1079368
    • Gegg ME, Beltran B, Salas-Pino S, Bolanos JP, Clark JB, Moncada S, Heales SJR (2003). Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurones: implications for neuroprotection/neurodegeneration?. Journal of Neurochemistry, 86(1), 228 - 237.
    • Cellek S, Foxwell NA, Moncada S (2003). Two phases of nitrergic neuropathy in streptozotocin-induced diabetic rats. Diabetes, 52, 2353 - 2362.
    • Mateo J, Garcia-Lecea M, Cadenas S, Hernandez C, Moncada S (2003). Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways. Biochemical Journal, 376, 537 - 544.
    • Hollis VS, Palacios-Callender M, Springett RJ, Delpy DT, Moncada S (2003). Monitoring cytochrome redox changes in the mitochondria of intact cells using multi-wavelength visible light spectroscopy. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1607(2-3), 191 - 202.
    • Connelly L, Jacobs AT, Palacios-Callender M, Moncada S, Hobbs AJ (2003). Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression. Journal of Biological Chemistry, 278, 26480 - 26487.
    • Rees RW, Foxwell NA, Ralph DJ, Kell PD, Moncada S, Cellek S (2003). Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells. The Journal of Urology, 170(6 Pt 1), 2517 - 2522.
    • Barsacchi R, Perrotta C, Bulotta S, Moncada S, Borgese N, Clementi E (2003). Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: A novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3 ' kinase, and Akt. MOL PHARMACOL, 63(4), 886 - 895.
    • Kalsi JS, Rees RW, Hobbs AJ, Royle M, Kell PD, Ralph DJ, Moncada S, Cellek S (2003). BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro. The Journal of Urology, 169(2), 761 - 766.
    • Hobbs AJ, Moncada S (2003). Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272. Vascular Pharmacology, 40, 149 - 154.
    • Edmunds NJ, Moncada S, Marshall JM (2003). Does nitric oxide allow endothelial cells to sense hypoxia and mediate hypoxic vasodilatation? In vivo and in vitro studies. The Journal of Physiology, 546, 521 - 527.
    • Lobos E, Nutman TB, Hothersall JS, Moncada S (2003). Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with Bancroftian Filariasis: association with tropical pulmonary eosinophilia or putative immunity. Infection and Immunity, 71, 747 - 753.
    • Gegg ME, Beltran B, Salas-Pino S, Bolanos JP, Clark JB, Moncada S, Heales SJ (2003). Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurones: implications for neuroprotection/neurodegeneration?. J Neurochem, 86(1), 228 - 237.

    2002

    • Beltran B, Quintero M, Garcia-Zaragoza E, O'Connor E, Esplugues JV, Moncada S (2002). Inhibition of mitochondrial respiration by endogenous nitric oxide: A critical step in Fas signaling. Proceedings of the National Academy of Sciences of the United States of America, 99, 8892 - 8897.
    • Fiorucci S, Mencarelli A, Mannucci R, Distrutti E, Morelli A, Del Soldato P, Moncada S (2002). NCX-4016, a nitric oxide-releasing aspirin, protects endothelial cells against apoptosis by modulating mitochondrial function. The FASEB Journal, 16, 1645 - 1647.
    • Barsacchi R, Perrotta C, Sestili P, Cantoni O, Moncada S, Clementi E (2002). Cyclic GMP-dependent inhibition of acid sphingomyelinase by nitric oxide: an early step in protection against apoptosis. Cell Death and Differentiation, 9, 1248 - 1255.
    • Ziessen T, Moncada S, Cellek S (2002). Characterization of the non-nitrergic NANC relaxation responses in the rabbit vaginal wall. British Journal of Pharmacology, 135, 546 - 554.
    • Rees RW, Ziessen T, Ralph DJ, Kell P, Moncada S, Cellek S (2002). Human and rabbit cavernosal smooth muscle cells express Rho-kinase. INT J IMPOT RES, 14(1), 1 - 7. doi:10.1038/sj/ijir/3900814
    • Rees RW, Ziessen T, Ralph DJ, Kell P, Moncada S, Cellek S (2002). Human and Rabbit cavernosal smooth muscle cells express Rho-kinase.
    • Moncada S, Erusalimsky JD (2002). Does nitric oxide modulate mitochondrial energy generation and apoptosis?. Nature Reviews Molecular Cell Biology, 3(3), 214 - 220.

    2001

    • Riobo NA, Clementi E, Melani M, Boveris A, Cadenas E, Moncada S, Poderoso JJ (2001). Nitric oxide inhibits mitochondrial NADH: ubiquinone reductase activity through peroxynitrite formation.
    • Almeida A, Almeida J, Bolanos JP, Moncada S (2001). Different responses of astrocytes and neurons to nitric oxide: The role of glycolytically generated ATP in astrocyte protection. Proceedings of the National Academy of Sciences of the United States of America, 98, 15294 - 15299.
    • Connelly L, Palacios-Callender M, Ameixa C, Moncada S, Hobbs AJ (2001). Biphasic regulation of NF-kB activity underlies the pro- and anti-inflammatory actions of nitric oxide. The Journal of Immunology, 166, 3873 - 3881.
    • Rees RW, Ralph DJ, Royle M, Moncada S, Cellek S (2001). Y-27632, an inhibitor of Rho-kinase, antagonizes noradrenergic contracts in the rabbit and human penile corpus cavernosum. British Journal of Pharmacology, 133, 455 - 458.
    • Borutaite V, Matthias A, Harris H, Moncada S, Brown GC (2001). Reversible inhibition of cellular respiration by nitric oxide in vascular inflammation. American Journal of Physiology, 281, H2256 - H2260.
    • Gounni AS, Spanel-Borowski K, Palacios M, Heusser C, Moncada S, Lobos E (2001). Pulmonary inflammation induced by a recombinant Brugia malayi gamma-glutamyl transpeptidase Homolog: Involvement of humoral autoimmune responses. Molecular Medicine, 7, 344 - 354.

    2000

    • Riobo NA, Clementi E, Melani M, Boveris A, Moncada S, Poderoso JJ (2000). Inhibition of NADH-ubiquinone reductase by nitric oxide is mediated by intramitochondrial peroxynitrite. In Moncada S, Gustafsson LE, Wiklund NP, Higgs EA (Ed.), The Biology of Nitric Oxide, Part 7 (pp. 221 - 221). : Portland Press.
    • Moncada S (2000). Introduction. In Mayer B (Ed.), Nitric Oxide. Handbook of Experimental Pharmacology (pp. 1 - 3). : Springer-Verlag.
    • Hallen K, Wiklund NP, Moncada S, Feelisch M (2000). Detection of S-nitrosothiols in biological fluids. In Moncada S, Gustafsson LE, Wiklund NP, Higgs EA (Ed.), The Biology of Nitric Oxide, Part 7 (pp. 109 - 109). : Portland Press.
    • Knowles R, Dawson J, Waslidge N, Russell R, Angell A, Craig C, Schwartz S, Evans S, Whittle B, Garvey E, Monkhouse J, Moncada S, Rees D (2000). GW273629 is a highly selective, short-acting iNOS (NOS-2) inhibitor both in vitro and in vivo: beneficial effects in endotoxin shock. In Moncada S, Gustafsson LE, Wiklund NP, Higgs EA (Ed.), The Biology of Nitric Oxide, Part 7 (pp. 21 - 21). : Portland Press.
    • Alderton W, Angell A, Clayton N, Craig C, Dawson J, Frend A, McGill J, Mangel S, Moncada S, Rees D, Russell L, Schwartz S, Waslidge N, Knowles R (2000). GW274150 is a potent, long-acting, highly selective inhibitor of inducible nitric oxide synthase (NOS-2) with therapeutic potential in post-operative ileus. In Moncada S, Gustaffson LE, Wiklund NP, Higgs EA (Ed.), The Biology of Nitric Oxide, Part 7 (pp. 22 - 22). : Portland Press.
    • Cellek S, Moncada S (2000). Nitrergic-noradrenergic interaction in the penile corpus cavernosum of diabetic rabbits. In Moncada S, Gustafsson LE, Wiklund NP, Higgs EA (Ed.), The Biology of Nitric Oxide, Part 7 (pp. 219 - 219). : Portland Press.
    • Beltran B, Orsi A, Clementi E, Moncada S (2000). Oxidative stress and S-nitrosylation of proteins in cells. British Journal of Pharmacology, 129, 953 - 960.
    • Teran E, Feelisch M, Sazanov L, Moncada S (2000). Nitric oxide reacts with ubiquinone to prevent the activity of purified complex I. In Moncada S, Gustafsson LE, Wiklund NP, Higgs EA (Ed.), The Biology of Nitric Oxide, Part 7 (pp. 7 - 7). : Portland Press.
    • Rees DD, Higgs EA, Moncada S (2000). Nitric oxide and the vessel wall. In Colman RW, Hirsh J, Marder VJ, Clowes AW, George JN (Ed.), Hemostasis and Thrombosis (pp. 673 - 682). : Lippincott Williams & Wilkins.
    • Moncada S (2000). Nitric oxide and cell respiration: physiology and pathology. Verh K Acad Geneeskd Belg, 3, 171 - 181.
    • Moncada S, Higgs EA (2000). Nitric oxide in cardiovascular function and disease. In Stemme S, Olsson AG (Ed.), Atherosclerosis XII, Proceedings of the XIIth International Symposium on Atherosclerosis, Stockholm, June 2000 (pp. 81 - 89). : Elsevier.
    • Beltran B, Orsi A, Clementi E, Moncada S (2000). Inhibition of complex I and GAPDH enzymes by NO is preceded by a decrease in GSH concentrations in several cell lines. In Moncada S, Gustafsson LE, Wiklund NP, Higgs EA (Ed.), The Biology of Nitric Oxide, Part 7 (pp. 8 - 8). : Portland Press.
    • Cellek S, Moncada S (2000). Nitrergic neurotransmission in the physiology of penile erection and pathophysiology of erectile dysfunction. In Toda N, Moncada S, Furchgott R, Higgs EA (Ed.), Nitric oxide and the peripheral nervous system (pp. 61 - 76). : Portland Press.
    • De Nadai C, Sestili P, Cantoni O, Lievremont JP, Sciorati C, Barsacchi R, Moncada S, Meldolesi J, Clementi E (2000). Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. P NATL ACAD SCI USA, 97(10), 5480 - 5485.
    • Orsi A, Beltran B, Clementi E, Hallen K, Feelisch M, Moncada S (2000). Continuous exposure to high concentrations of nitric oxide leads to persistent inhibition of oxygen consumption by J774 cells as well as extraction of oxygen by the extracellular medium. Biochemical Journal, 346, 407 - 412.
    • Vallance P, Rees D, Moncada S (2000). Therapeutic potential of NOS inhibitors in septic shock. In Mayer B (Ed.), Nitric oxide. Handbook of Experimental Pharmacology (pp. 385 - 397). : Springer-Verlag.
    • Orsi A, Rees DD, Beltran B, Moncada S (2000). Physiological regulation and pathological inhibition of tissue respiration by nitric oxide in vivo. In Moncada S, Gustaffson LE, Wiklund NP, Higgs EA (Ed.), The Biology of Nitric Oxide, Part 7 (pp. 35 - 35). : Portland Press.
    • Beltran B, Mathur A, Duchen MR, Erusalimsky JD, Moncada S (2000). The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death. Proceedings of the National Academy of Sciences of the United States of America, 97(26), 14602 - 14607.

    1999

    • Wiklund NP, Iversen HH, Leone AM, Cellek S, Brundin L, Gustafsson LE, Moncada S (1999). Visualization of nitric oxide formation in cell cultures and living tissue.. Acta Physiologica Scandinavica, 167, 161 - 166.
    • Chabrier P, Auguet M, Spinnewyn B, Auvin S, Cornet S, Demerle-Pallardy C, Guilmard-Favre C, Marin J, Pignol B, Gillard-Roubert V, Roussillot-Charnet C, Schulz J, Viossat I, Bigg D, Moncada S (1999). BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: A promising neuroprotective strategy. Proceedings of the National Academy of Sciences of the United States of America, 96, 10824 - 10829.
    • Wolzt M, MacAllister RJ, Davis D, Feelisch M, Moncada S, Vallance P, Hobbs AJ (1999). Biochemical characterization of S-nitrosohaemoglobin: mechanisms underlying synthesis, NO release, and biological activity. Journal of Biological Chemistry, 274, 28983 - 28990.
    • Moncada S, Higgs EA (1999). Discovery of Biological Roles of Nitric Oxide in the Cardiovascular System. In Panza JA, Cannon ROI (Ed.), Endothelium, Nitric Oxide and Atherosclerosis (pp. 13 - 27). : Futura Publishing Co Inc.
    • Robinson NMK, Zhang HY, Bevan AL, de Belder AJ, Moncada S, Martin J, Archard LC (1999). Induction of myocardial nitric oxide synthase by Coxsackie B3 virus in mice. European Journal of Clinical Investigation, 29, 700 - 707.
    • Moncada S (1999). The biology of nitric oxide. In Day P (Ed.), Proceedings of The Royal Institution (pp. 235 - 248). : Oxford University Press.
    • Moilanen E, Whittle B, Moncada S (1999). Nitric oxide as a factor in inflammation. In Gallin JI, Snyderman R (Ed.), Inflammation, Basic Principles and Clinical Correlates (pp. 787 - 800). : Lippincott Williams & Wilkins.
    • Moncada S (1999). Nitric oxide: discovery and impact on clinical medicine. Journal of the Royal Society of Medicine, 92, 164 - 169.
    • Cellek S, Ziessen T, Moncada S (1999). Non-adrenergic non-cholinergic responses in the rabbit vaginal wall are mediated by nitrergic neurotransmission. British Journal of Pharmacology, 126, 98P - 98P.
    • Clementi E, Brown GC, Foxwell N, Moncada S (1999). On the mechanism by which vascular endothelial cells regulate their oxygen consumption. Proceedings of the National Academy of Sciences of the United States of America, 96, 1559 - 1562.
    • Cellek S, Rodrigo J, Lobos E, Fernandez P, Serrano J, Moncada S (1999). Selective nitrergic neurodegeneration in diabetes mellitus - a nitric oxide-dependent phenomenon. British Journal of Pharmacology, 128, 1804 - 1812.
    • Hobbs AJ, Higgs A, Moncada S (1999). Inhibition of nitric oxide synthase as a potential therapeutic target. Annual Review of Pharmacology and Toxicology, 39, 191 - 220.

    1998

    • Moncada S (1998). Collaborative research and development. Journal of the Royal Society of Medicine, 91(36), 21 - 22.
    • Cellek S, Moncada S (1998). Nitrergic neurotransmission mediates the non-adrenergic non-cholinergic responses in the clitoral corpus cavernosum of the rabbit. British Journal of Pharmacology, 125, 1627 - 1629.
    • Hobbs AJ, Moncada S (1998). Inducible nitric oxide synthase and inflammation. In Willoughby DA, Tomlinson A (Ed.), Inducible enzymes in the inflammatory response (pp. 31 - 54). : Birkhauser Verlag.
    • Zaragoza C, Ocampo C, Saura M, Leppo M, Wei XQ, Quick R, Moncada S, Liew FY, Lowenstein CJ (1998). The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis. Proceedings of the National Academy of Sciences of the United States of America, 95(5), 2469 - 2474.
    • Rees DD, Monkhouse JE, Cambridge D, Moncada S (1998). Nitric oxide and the haemodynamic profile of endotoxin shock in the conscious mouse. BR J PHARMACOL, 124(3), 540 - 546.
    • Lamas S, Perez-Sala D, Moncada S (1998). Nitric oxide: from discovery to the clinic. Trends in Pharmacological Sciences, 19, 436 - 438.
    • Moncada S (1998). Papel del oxido nitrico en la respiracion celular. Medicina, Buenos Aires, 58, 357 - 360.
    • Clementi E, Brown GC, Feelisch M, Moncada S (1998). Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proceedings of the National Academy of Sciences of the United States of America, 95(13), 7631 - 7636.
    • Dugas N, Palacios-Callender M, Dugas B, Riveros-Moreno V, Delfraissy JF, Kolb JP, Moncada S (1998). Regulation by endogenous interleukin-10 of the expression of nitric oxide synthase induced after ligation of CD23 in human monocytes.. Cytokine, 10(9), 680 - 689.
    • Brown GC, Foxwell N, Moncada S (1998). Transcellular regulation of cell respiration by nitric oxide generated by activated macrophages. FEBS Letters, 439(3), 321 - 324.
    • Moilanen E, Thomsen LL, Miles DW, Happerfield DW, Knowles RG, Moncada S (1998). Persistent induction of nitric oxide synthase in tumours from mice treated with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid. British Journal of Cancer, 77(3), 426 - 433.
    • Salas E, Langford EJ, Marrinan MT, Martin JF, Moncada S, de Belder AJ (1998). S-nitrosoglutathione inhibits platelet activation and deposition in coronary artery saphenous vein grafts in vitro and in vivo. HEART, 80(2), 146 - 150.
    • Lopez J, Ruano C, Rivera J, Teran E, Salazar I, Esplugues JV, Moncada S (1998). Treatment of cutaneous leishmaniasis with nitric-oxide donor. The Lancet, 351(9110), 1176 - 1177.

    1997

    • Cellek S, Moncada S (1997). Nitrergic modulation of cholinergic responses in the opossum lower oesophageal sphincter. BR J PHARMACOL, 122(6), 1043 - 1046.
    • Cellek S, Moncada S (1997). Nitrergic control of peripheral sympathetic responses in the human corpus cavernosum: A comparison with other species. PROC NATL ACAD SCI USA, 94(15), 8226 - 8231.
    • Jewell T, Green R, Tomlinson S, Lane D, Vallance P, Khaw K, Radda G, Radford T, Moncada S, Savill J (1997). National Health under new management. The Lancet, 350, 48 - 58.
    • Smith REA, Robinson NMK, McPeake JR, Baylis SA, Charles IG, Heaton ND, Moncada S, Williams R, Martin JF (1997). Induction and role of NO synthase in hypotensive hepatic failure. ARTERIOSCLER THROMB VASC BIOL, 17, 3079 - 3082.
    • Cellek S, Moncada S (1997). Modulation of noradrenergic responses by nitric oxide from inducible nitric oxide synthase. NITRIC OXIDE: BIOL CHEM, 1(3), 204 - 210.
    • de Belder A, Robinson N, Richardson P, Martin J, Moncada S (1997). Expression of inducible nitric oxide synthase in human heart failure. Circulation, 95(6), 1672 - 1673.
    • Moncada S (1997). Commentary on "Prostacyclin" (PGI2) inhibits the formation of platelet thrombi in arterioles and venules of the hamster cheek pouch".. British Journal of Pharmacology, 120(4), 437 - 438.
    • Moncada S (1997). Commentary on "Bioassay of prostacyclin and endothelium-derived relaxing factor (EDRF) from porcine aortic endothelial cells.. British Journal of Pharmacology, 120(4), 491 - 493.
    • Moncada S (1997). Aventuras en farmacologia: veinte anos de casualidad y diseno. Revista Hondurena de Neurociencias, 1, 41 - 74.
    • Moncada S (1997). Adventures in pharmacology, aspirin, prostacyclin and nitric oxide. METHODS FIND EXP CLIN PHARMACOL, 19, 3 - 5.
    • Moncada S (1997). "Ottorino Rossi" Award 1997. The biology of nitric oxide. FUNCT NEUROL, 12, 135 - 140.
    • Moncada S (1997). The biology of nitric oxide. FUNCT NEUROL, 12(3-4), 135 - 140.
    • Moncada S (1997). "Ottorino Rossi" Award 1997. The biology of nitric oxide.. Funct Neurol, 12(3-4), 134 - 140.
    • Moncada S, Higgs A, Furchgott R (1997). XIV International Union of Pharmacology: Nomenclature in Nitric Oxide Research. PHARMACOL REVS, 49(2), 137 - 142.
    • Rodrigo J, Riveros-Moreno V, Bentura ML, Uttenthal LO, Higgs EA, Fernandez AP, Polak JM, Moncada S, Martinez-Murillo R (1997). Subcellular localization of nitric oxide synthase in the cerebral ventricular system, subfornical organ, area postrema, and blood vessels of the rat brain. J COMPARAT NEUROL, 378, 522 - 534.
    • Martin GR, Robertson AD, MacLennan SJ, Prentice DJ, Barrett VJ, Buckingham J, Honey AC, Giles H, Moncada S (1997). Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT 1B/1D receptor partial agonist, 311C90 (zolmitriptan). BR J PHARMACOL, 121(2), 157 - 164.
    • Wiklund NP, Cellek S, Leone AM, Iversen HH, Gustafsson LE, Brundin L, Furst VW, Flock A, Moncada S (1997). Visualisation of nitric oxide released by nerve stimulation. Journal of Neuroscience Research, 47, 224 - 232.
    • Moilanen E, Moilanen T, Knowles R, Charles I, Kadoya Y, Al-Saffar N, Revell PA, Moncada S (1997). Nitric oxide synthase is expressed in human macrophages during foreign body inflammation. American Journal of Pathology, 150(3), 881 - 887.
    • Vallance P, Moncada S (1997). Nitric oxide and hypertension: physiology and pathophysiology.. In Webb D, Vallance P (Ed.), Endothelial Function in Hypertension (pp. - ). : Springer Verlag.
    • Moncada S (1997). Nitric oxide in the vasculature: Physiology and Pathophysiology. ANNALS OF THE NEW YORK ACAD SCI, 811, 60 - 69.

    1995

    • Dugas B, Debre P, Moncada S (1995). Nitric oxide, a vital poison inside the immune and inflammatory network. RES IMMUNOL, 146(9), 664 - 670.

    1994

    • Cleeter MW, Cooper JM, Darley-Usmar VM, Moncada S, Schapira AH (1994). Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett., 345(1), 50 - 54.