Dr Richard Milne


Personal Profile

Name: Richard Milne Email: richard.milne@ucl.ac.uk
Title: Dr Tel:
Department: Div of Infection & Immunity Fax:
Position: Senior Lecturer Address: Department of Virology, UCL Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2PF
Research Domain: Experimental Medicine, Infection, Immunology & Inflammation, Personalised Medicine Web Page:  


Research Description

Virus entry Virus receptor interactions Virus trafficking Immune response to herpes infection

Research Activities

CMV Pathogenesis and Development of Vaccines


Education Description

UCL Collaborators

Prof Paul Griffiths; Prof Richard Tedder; Prof Caroline Sabin; Prof Deenan Pillay; Prof Paul Kellam

External Collaborators



    • Blondeau C, Pelchen-Matthews A, Mlcochova P, Marsh M, Milne RS, Towers GJ (2013). Tetherin restricts herpes simplex virus 1 and is antagonized by glycoprotein M.. J Virol, 87(24), 13124 - 13133. doi:10.1128/JVI.02250-13


    • Atabani SF, Smith C, Atkinson C, Aldridge RW, Rodriguez-Perálvarez M, Rolando N, Harber M, Jones G, O'Riordan A, Burroughs AK, Thorburn D, O'Beirne J, Milne RS, Emery VC, Griffiths PD (2012). Cytomegalovirus replication kinetics in solid organ transplant recipients managed by preemptive therapy.. Am J Transplant, 12(9), 2457 - 2464. doi:10.1111/j.1600-6143.2012.04087.x
    • Marashi SM, Raeiszadeh M, Enright V, Tahami F, Workman S, Chee R, Webster AD, Milne RS, Emery VC (2012). Influence of cytomegalovirus infection on immune cell phenotypes in patients with common variable immunodeficiency.. J Allergy Clin Immunol, 129(5), 1349 - 1356.e3. doi:10.1016/j.jaci.2012.02.011


    • Emery VC, Milne RSB (2011). Recent developments in antiviral drugs for cytomegalovirus. FUTURE VIROL, 6(5), 633 - 651. doi:10.2217/FVL.11.30
    • Marashi SM, Raeiszadeh M, Workman S, Rahbar A, Soderberg-Naucler C, Klenerman P, Chee R, Webster AD, Milne RS, Emery VC (2011). Inflammation in common variable immunodeficiency is associated with a distinct CD8(+) response to cytomegalovirus.. J Allergy Clin Immunol, 127(6), 1385 - 93.e4. doi:10.1016/j.jaci.2011.04.001
    • Griffiths PD, Milne RSB (2011). Intracellular neutralisation of adenovirus by antibody. REV MED VIROL, 21(1), 1 - 2. doi:10.1002/rmv.675
    • Griffiths PD, Stanton A, McCarrell E, Smith C, Osman M, Harber M, Davenport A, Jones G, Wheeler DC, O'Beirne J, Thorburn D, Patch D, Atkinson CE, Pichon S, Sweny P, Lanzman M, Woodford E, Rothwell E, Old N, Kinyanjui R, Haque T, Atabani S, Luck S, Prideaux S, Milne RS, Emery VC, Burroughs AK (2011). Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial.. Lancet, 377(9773), 1256 - 1263. doi:10.1016/S0140-6736(11)60136-0


    • Lagos D, Pollara G, Henderson S, Gratrix F, Fabani M, Milne RS, Gotch F, Boshoff C (2010). miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator.. Nat Cell Biol, 12(5), 513 - 519. doi:10.1038/ncb2054


    • Stiles KM, Milne RS, Cohen GH, Eisenberg RJ, Krummenacher C (2008). The herpes simplex virus receptor nectin-1 is down-regulated after trans-interaction with glycoprotein D.. Virology, 373(1), 98 - 111.


    • Whitbeck JC, Zuo Y, Milne RS, Cohen GH, Eisenberg RJ (2006). Stable association of herpes simplex virus with target membranes is triggered by low pH in the presence of the gD receptor, HVEM.. Journal of Virology, 80(8), 3773 - 3780. doi:10.1128/JVI.79.11.6655-6663.2005
    • Whitbeck JC, Zuo Y, Milne RSB, Cohen GH, Eisenberg RJ (2006). Stable association of herpes simplex virus with target membranes is triggered by low pH in the presence of the gD receptor, HVEM. J VIROL, 80(8), 3773 - 3780. doi:10.1128/JVI.80.8.3773-3780.2006


    • Milne RS, Nicola AV, Whitbeck JC, Eisenberg RJ, Cohen GH (2005). Glycoprotein D receptor-dependent, low-pH-independent endocytic entry of herpes simplex virus type 1.. Journal of Virology, 79(11), 6655 - 6663. doi:10.1128/JVI.79.11.6655-6663-2005


    • Milne RS, Hanna SL, Rux AH, Willis SH, Cohen GH, Eisenberg RJ (2003). Function of herpes simplex virus type 1 gD mutants with different receptor-binding affinities in virus entry and fusion.. Journal of Virology, 77(16), 8962 - 8972. doi:10.1128/JVI.77.16.8962-8972.2003
    • Cairns TM, Milne RS, Ponce-de-Leon M, Tobin DK, Cohen GH, Eisenberg RJ (2003). Structure-function analysis of herpes simplex virus type 1 gD and gH-gL: clues from gDgH chimeras.. Journal of Virology, 77(12), 6731 - 6742.


    • Paterson DA, Dyer AP, Milne RSB, Sevilla-Reyes E, Gompels UA (2002). A role for human cytomegalovirus glycoprotein O (gO) in cell fusion and a new hypervariable locus. VIROLOGY, 293(2), 281 - 294. doi:10.1006/viro.2001.1274


    • Milne RSB, Connolly SA, Krummenacher C, Eisenberg RJ, Cohen GH (2001). Porcine HveC, a member of the highly conserved HveC/Nectin 1 family, is a functional alphaherpesvirus receptor. VIROLOGY, 281(2), 315 - 328. doi:10.1006/viro.2000.0798


    • Milne RSB, Mattick C, Nicholson L, Devaraj P, Alcami A, Gompels UA (2000). RANTES binding and down-regulation by a novel human herpesvirus-6 beta chemokine receptor. J IMMUNOL, 164(5), 2396 - 2404.
    • Zal B, Pinto-Basto J, Milne R, Jeeachee M, Baboonian C (2000). Immunological analysis of the tegument phosphoprotein ppUL83 of human cytomegalovirus. J Virol Methods, 85(1-2), 183 - 192.


    • Milne RSB, Paterson DA, Booth JC (1998). Human cytomegalovirus glycoprotein H glycoprotein L complex modulates fusion-from-without. J GEN VIROL, 79, 855 - 865.