Prof Timothy Mchugh

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Personal Profile

Name: Timothy Mchugh Email: t.mchugh@ucl.ac.uk
Title: Prof Tel: 020 7472 6402
Department: Div of Infection & Immunity Fax: 020 7794 0433
Position: Professor of Medical Microbiology Address: Centre for Clinical Microbiology, Royal Free Campus, Rowland Hill Street, London, NW3 2QG
Research Domain: Global Health, Infection, Immunology & Inflammation, Personalised Medicine Web Page:  

Profile

Research Description


Research Activities

COPD exacerbations

Microorganisms and immunoregulation

Education Description

UCL Collaborators

Prof Tom Rademacher; Prof Graham Rook; Prof Ali Zumla; Dr Mahdad Noursadeghi

External Collaborators

Publications

    2014

    • Honeyborne I, Mtafya B, Phillips PP, Hoelscher M, Ntinginya EN, Kohlenberg A, Rachow A, Rojas-Ponce G, McHugh TD, Heinrich N, On behalf of the Pan African Consortium for the Evaluation of Anti-tuberculosis Antibiotics (PanACEA) (2014). The Molecular Bacterial Load Assay replaces solid culture for measuring early bactericidal response to anti-tuberculosis treatment.. J Clin Microbiol, , - . doi:10.1128/JCM.01128-14
    • Houben RM, Yates TA, Moore DA, McHugh TD, Lipman M, Vynnycky E (2014). RE: "ESTIMATED RATE OF REACTIVATION OF LATENT TUBERCULOSIS INFECTION IN THE UNITED STATES, OVERALL AND BY POPULATION SUBGROUP". Am J Epidemiol, , - . doi:10.1093/aje/kwu187
    • McGuigan C, Derudas M, Gonczy B, Hinsinger K, Kandil S, Pertusati F, Serpi M, Snoeck R, Andrei G, Balzarini J, McHugh TD, Maitra A, Akorli E, Evangelopoulos D, Bhakta S (2014). ProTides of N-(3-(5-(2'-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents.. Bioorg Med Chem, , - . doi:10.1016/j.bmc.2014.02.056
    • Zumla AI, Gillespie SH, Hoelscher M, Philips PP, Cole ST, Abubakar I, McHugh TD, Schito M, Maeurer M, Nunn AJ (2014). New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects.. Lancet Infect Dis, 14(4), 327 - 340. doi:10.1016/S1473-3099(13)70328-1
    • Gorton RL, Ramnarain P, Barker K, Stone N, Rattenbury S, McHugh TD, Kibbler CC (2014). Comparative analysis of Gram's stain, PNA-FISH and Sepsityper with MALDI-TOF MS for the identification of yeast direct from positive blood cultures.. Mycoses, , - . doi:10.1111/myc.12205
    • Bhatti M, McHugh TD, Milanesi L, Tomas S (2014). Self-assembled nanoparticles as multifunctional drugs for anti-microbial therapies.. Chem Commun (Camb), , - . doi:10.1039/c4cc00349g
    • Guzman JD, Mortazavi PN, Munshi T, Bhakta S, Gibbons S, Malkinson J, Evangelopoulos D, McHugh TD (2014). 2-Hydroxy-substituted cinnamic acids and acetanilides are selective growth inhibitors of Mycobacterium tuberculosis. MedChemComm, 5(1), 47 - 50. doi:10.1039/c3md00251a
    • Gorton RL, Seaton S, Ramnarain P, McHugh TD, Kibbler CC (2014). Evaluation of a short, on-plate formic acid (FA) extraction method for MALDI-TOF MS-based identification of clinically relevant yeast isolates.. J Clin Microbiol, , - . doi:10.1128/JCM.03489-13
    • Satta G, McHugh TD, Mountford J, Abubakar I, Lipman M (2014). Managing Pulmonary Nontuberculous Mycobacterial Infection. Time for a Patient-centered Approach.. Ann Am Thorac Soc, 11(1), 117 - 121. doi:10.1513/AnnalsATS.201308-278OT
    • Ling CL, Oravcova K, Beattie TF, Creer DD, Dilworth P, Fulton NL, Hardie A, Munro M, Pond M, Templeton K, Webster D, Workman S, McHugh TD, Gillespie SH (2014). Tools for detection of Mycoplasma amphoriforme; a primary respiratory pathogen?. J Clin Microbiol, , - . doi:10.1128/JCM.03049-13
    • McHugh TD (2014). World TB Day 2014: Reach the three million: a TB test, treatment and cure for all.. Trans R Soc Trop Med Hyg, 108(3), 119 - 120. doi:10.1093/trstmh/tru006

    2013

    • Lawn SD, Mwaba P, Bates M, Piatek A, Alexander H, Marais BJ, Cuevas LE, McHugh TD, Zijenah L, Kapata N, Abubakar I, McNerney R, Hoelscher M, Memish ZA, Migliori GB, Kim P, Maeurer M, Schito M, Zumla A (2013). Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test.. Lancet Infect Dis, 13(4), 349 - 361. doi:10.1016/S1473-3099(13)70008-2
    • Abubakar I, Zignol M, Falzon D, Raviglione M, Ditiu L, Masham S, Adetifa I, Ford N, Cox H, Lawn SD, Marais BJ, McHugh TD, Mwaba P, Bates M, Lipman M, Zijenah L, Logan S, McNerney R, Zumla A, Sarda K, Nahid P, Hoelscher M, Pletschette M, Memish ZA, Kim P, Hafner R, Cole S, Migliori GB, Maeurer M, Schito M, Zumla A (2013). Drug-resistant tuberculosis: time for visionary political leadership.. Lancet Infect Dis, 13(6), 529 - 539. doi:10.1016/S1473-3099(13)70030-6
    • Kumar K, Shorten RJ, Capocci S, Solamalai A, Goodburn A, Cropley I, McHugh TD, Lipman M (2013). The value of "inform and advise" guidance in a case of extensive tuberculosis transmission.. J Infect, 67(2), 158 - 160. doi:10.1016/j.jinf.2013.04.005
    • (2013). Tuberculosis: Laboratory Diagnosis and Treatment Strategies.
    • Bryant JM, Harris SR, Parkhill J, Dawson R, Diacon AH, van Helden P, Pym A, Mahayiddin AA, Chuchottaworn C, Sanne IM, Louw C, Boeree MJ, Hoelscher M, McHugh TD, Bateson AL, Hunt RD, Mwaigwisya S, Wright L, Gillespie SH, Bentley SD (2013). Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study.. Lancet Respir Med, 1(10), 786 - 792. doi:10.1016/S2213-2600(13)70231-5
    • Honeyborne I, Eckold C, Gillespie SH, Lipman M, Pym A, McHugh TD (2013). DRAMATIC DECLINE IN PLASMA SMALL RNA CONCENTRATION IN HIV-INFECTED AND UNINFECTED INDIVIDUALS RECEIVING ANTI-TUBERCULOSIS THERAPY: A PUTATIVE BIOMARKER OF TREATMENT RESPONSE. doi:10.1136/thoraxjnl-2013-204457.66
    • Ling CL, McHugh TD (2013). Rapid detection of atypical respiratory bacterial pathogens by real-time PCR.. Methods Mol Biol, 943, 125 - 133. doi:10.1007/978-1-60327-353-4_8
    • Moreira JB, Mann J, Neidle S, McHugh TD, Taylor PW (2013). Antibacterial activity of head-to-head bis-benzimidazoles.. Int J Antimicrob Agents, , - . doi:10.1016/j.ijantimicag.2013.04.033
    • Friedrich SO, Rachow A, Saathoff E, Singh K, Mangu CD, Dawson R, Phillips PP, Venter A, Bateson A, Boehme CC, Heinrich N, Hunt RD, Boeree MJ, Zumla A, McHugh TD, Gillespie SH, Diacon AH, Hoelscher M (2013). Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment. The Lancet Respiratory Medicine, , - .
    • Moganeradj K, Abubakar I, McHugh TD, Sonnenberg P, Arnold C (2013). Insertion site mapping for repeated elements in Mycobacterium tuberculosis.. J Microbiol Methods, 92(2), 192 - 196. doi:10.1016/j.mimet.2012.12.005
    • Gorton R, Ozongwu C, Akhtar S, McHugh TD, Kibbler CC (2013). Evaluation of the Bruker MALDI BioTyper (TM) 3 database for the identification of filamentous fungi compared with conventional identification and ITS rRNA genotyping. MYCOSES, 56, 43 - 44.
    • Shorten RJ, McGregor AC, Platt S, Jenkins C, Lipman MC, Gillespie SH, Charalambous BM, McHugh TD (2013). When is an outbreak not an outbreak? Fit, divergent strains of Mycobacterium tuberculosis display independent evolution of drug resistance in a large London outbreak.. J Antimicrob Chemother, 68(3), 543 - 549. doi:10.1093/jac/dks430
    • Satta G, Ling CL, Cunningham ES, McHugh TD, Hopkins S (2013). Utility and limitations of Spa-typing in understanding the epidemiology of staphylococcus aureus bacteraemia isolates in a single University Hospital.. BMC Res Notes, 6(1), 398 - . doi:10.1186/1756-0500-6-398
    • Guzman JD, Evangelopoulos D, Gupta A, Birchall K, Mwaigwisya S, Saxty B, McHugh TD, Gibbons S, Malkinson J, Bhakta S (2013). Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay.. BMJ Open, 3(6), - . doi:10.1136/bmjopen-2013-002672

    2012

    • Coxon GD, Cooper CB, Gillespie SH, McHugh TD (2012). Strategies and challenges involved in the discovery of new chemical entities during early-stage tuberculosis drug discovery.. J Infect Dis, 205 Suppl 2, S258 - S264. doi:10.1093/infdis/jis191
    • Zumla A, Abubakar I, Raviglione M, Hoelscher M, Ditiu L, McHugh TD, Squire SB, Cox H, Ford N, McNerney R, Marais B, Grobusch M, Lawn SD, Migliori GB, Mwaba P, O'Grady J, Pletschette M, Ramsay A, Chakaya J, Schito M, Swaminathan S, Memish Z, Maeurer M, Atun R (2012). Drug-resistant tuberculosis--current dilemmas, unanswered questions, challenges, and priority needs.. J Infect Dis, 205 Suppl 2, S228 - S240. doi:10.1093/infdis/jir858
    • McNerney R, Maeurer M, Abubakar I, Marais B, McHugh TD, Ford N, Weyer K, Lawn S, Grobusch MP, Memish Z, Squire SB, Pantaleo G, Chakaya J, Casenghi M, Migliori GB, Mwaba P, Zijenah L, Hoelscher M, Cox H, Swaminathan S, Kim PS, Schito M, Harari A, Bates M, Schwank S, O'Grady J, Pletschette M, Ditui L, Atun R, Zumla A (2012). Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities.. J Infect Dis, 205 Suppl 2, S147 - S158. doi:10.1093/infdis/jir860
    • Kottakota SK, Evangelopoulos D, Alnimr A, Bhakta S, McHugh TD, Gray M, Groundwater PW, Marrs EC, Perry JD, Spilling CD, Harburn JJ (2012). Synthesis and biological evaluation of purpurealidin E-derived marine sponge metabolites: aplysamine-2, aplyzanzine A, and suberedamines A and B.. J Nat Prod, 75(6), 1090 - 1101. doi:10.1021/np300102z
    • Garcha DS, Thurston SJ, Patel AR, Mackay AJ, Goldring JJ, Donaldson GC, McHugh TD, Wedzicha JA (2012). Changes in prevalence and load of airway bacteria using quantitative PCR in stable and exacerbated COPD.. Thorax, 67(12), 1075 - 1080. doi:10.1136/thoraxjnl-2012-201924
    • Markarian SA, Evangelopoulos D, Harutyunyan LR, Pepoyan EK, Guzman JD, McHugh TD, Bhakta S (2012). The Properties of Solutions of Isoniazid in Water and Dimethylsulfoxide. JOURNAL OF SOLUTION CHEMISTRY, 41(9), 1462 - 1476. doi:10.1007/s10953-012-9883-7
    • Kottakota SK, Benton M, Evangelopoulos D, Guzman JD, Bhakta S, McHugh TD, Gray M, Groundwater PW, Marrs EC, Perry JD, Harburn JJ (2012). Versatile routes to marine sponge metabolites through benzylidene rhodanines.. Org Lett, 14(24), 6310 - 6313. doi:10.1021/ol303057a
    • Thurston SJ, McHugh TD, Donaldson GC, Wedzicha JA (2012). PROFILE OF THE AIRWAY MICROBIOME IN COPD USING MALDI-TOF. doi:10.1136/thoraxjnl-2012-202678.030
    • Phillips PP, Gillespie SH, Boeree M, Heinrich N, Aarnoutse R, McHugh T, Pletschette M, Lienhardt C, Hafner R, Mgone C, Zumla A, Nunn AJ, Hoelscher M (2012). Innovative trial designs are practical solutions for improving the treatment of tuberculosis.. J Infect Dis, 205 Suppl 2, S250 - S257. doi:10.1093/infdis/jis041
    • Osman K, Evangelopoulos D, Basavannacharya C, Gupta A, McHugh TD, Bhakta S, Gibbons S (2012). An antibacterial from Hypericum acmosepalum inhibits ATP-dependent MurE ligase from Mycobacterium tuberculosis.. Int J Antimicrob Agents, 39(2), 124 - 129. doi:10.1016/j.ijantimicag.2011.09.018
    • Jenkins C, Ling CL, Ciesielczuk HL, Lockwood J, Hopkins S, McHugh TD, Gillespie SH, Kibbler CC (2012). Detection and identification of bacteria in clinical samples by 16S rRNA gene sequencing: comparison of two different approaches in clinical practice.. J Med Microbiol, 61(Pt 4), 483 - 488. doi:10.1099/jmm.0.030387-0

    2011

    • James C, Wey E, McHugh T, James E (2011). MICROBES: SHAPE, COLOUR AND PATTERN - A COMMUNITY ART PROJECT USING FAMILY LEARNING TO PROMOTE UNDERSTANDING OF BIOMEDICAL SCIENCECATEGORY: LESSON IN MICROBIOLOGY & INFECTION CONTROL. JOURNAL OF INFECTION, 63(6), E71 - E71.
    • Guzman JD, Wube A, Evangelopoulos D, Gupta A, H├╝fner A, Basavannacharya C, Rahman MM, Thomaschitz C, Bauer R, McHugh TD, Nobeli I, Prieto JM, Gibbons S, Bucar F, Bhakta S (2011). Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics.. J Antimicrob Chemother, 66(8), 1766 - 1772. doi:10.1093/jac/dkr203
    • Honeyborne I, McHugh TD, Phillips PP, Bannoo S, Bateson A, Carroll N, Perrin FM, Ronacher K, Wright L, van Helden PD, Walzl G, Gillespie SH (2011). Molecular bacterial load assay, a culture-free biomarker for rapid and accurate quantification of sputum Mycobacterium tuberculosis bacillary load during treatment.. J Clin Microbiol, 49(11), 3905 - 3911. doi:10.1128/JCM.00547-11
    • Gorton RL, Stone NARH, Ramnarain P, Barker K, Mchugh TD, Kibbler CC (2011). A comparison of three rapid identification techniques for the identification of yeasts from positive blood cultures: Gram's stain, PNA-FISH and MALDI-TOF. MYCOSES, 54, 78 - 78.
    • Ling C, Malloy A, Hopkins S, Ciesielczuk H, Lockwood J, McHugh T, Gillespie S (2011). IMPROVING THE DIAGNOSIS OF BACTERIAL RESPIRATORY TRACT INFECTIONS. JOURNAL OF INFECTION, 63(6), 490 - 491.
    • Garcha DS, Thurston SJ, Patel ARC, Mackay AJ, Goldring JJP, McHugh TD, Donaldson GC, Wedzicha JA (2011). A COMPARISON OF PREVALENCE AND LOAD OF AIRWAY BACTERIA IN COPD PATIENTS WITH PAIRED STABLE AND EXACERBATION STATE SAMPLES. doi:10.1136/thoraxjnl-2011-201054b.18
    • Thurston SJ, Donaldson GC, McHugh TD, Wedzicha JA (2011). IMPACT OF COPD SEVERITY AND SPUTUM PRODUCTION ON ANTIBIOTIC RESISTANCE. doi:10.1136/thoraxjnl-2011-201054b.17
    • Satta G, Ling C, McHugh TD, Hopkins S (2011). UTILITY OF SPA TYPING IN UNDERSTANDING EPIDEMIOLOGY OF STAPHYLOCOCCUS AUREUS BACTERAEMIA ISOLATES IN A SINGLE UNIVERSITY HOSPITALCATEGORY: SCIENTIFIC FREE PAPER. JOURNAL OF INFECTION, 63(6), E51 - E52.

    2010

    • Garcha DS, Thurston SJ, Patel ARC, Goldring JJP, McHugh TD, Donaldson GC, Wedzicha JA (2010). QUANTITATIVE PCR-BASED DETECTION AND QUANTIFICATION OF ATYPICAL BACTERIA AT BASELINE AND EXACERBATION OF COPD. doi:10.1136/thx.2010.150987.11
    • Perrin FM, Woodward N, Phillips PP, McHugh TD, Nunn AJ, Lipman MC, Gillespie SH (2010). Radiological cavitation, sputum mycobacterial load and treatment response in pulmonary tuberculosis.. Int J Tuberc Lung Dis, 14(12), 1596 - 1602.
    • O'Sullivan DM, McHugh TD, Gillespie SH (2010). Mapping the fitness of Mycobacterium tuberculosis strains: a complex picture.. J Med Microbiol, 59(Pt 12), 1533 - 1535. doi:10.1099/jmm.0.019091-0
    • Pope CF, Gillespie SH, Moore JE, McHugh TD (2010). Approaches to measure the fitness of Burkholderia cepacia complex isolates.. J Med Microbiol, 59(Pt 6), 679 - 686. doi:10.1099/jmm.0.017830-0
    • Pope CF, McHugh TD, Gillespie SH (2010). Methods to determine fitness in bacteria.. Methods Mol Biol, 642, 113 - 121. doi:10.1007/978-1-60327-279-7_9
    • Breathnach A, McHugh TD, Butcher PD (2010). Prevalence and clinical correlations of genetic subtypes of Giardia lamblia in an urban setting. Epidemiology and Infection, 138(10), 1459 - 1467. doi:10.1017/S0950268810000208
    • (2010). Antibiotic Resistance Protocols, Second edition.
    • Charalambous BM, McHugh TD (2010). Immunological principles of vaccination (Theory). In Jong EC, Zuckerman JD (Ed.), Travelers' Vaccines. (pp. - ). : BC Decker Inc.

    2009

    • McHugh TD (2009). How to Look Sensible When Requesting a Molecular Microbiological Diagnosis. Bugs & Drugs, 13(2), - .
    • McHugh TD (2009). Molecular diagnosis of antibiotic resistance.
    • Perrin FM, Breen RA, McHugh TD, Gillespie SH, Lipman MC (2009). Are patients on treatment for pulmonary TB who stop expectorating sputum genuinely culture negative?. Thorax, 64(11), 1009 - 1010.
    • Jenkins C, Bacon J, Allnutt J, Hatch KA, Bose A, O Sullivan DM, Arnold C, Gillespie SH, McHugh TD (2009). Enhanced heterogeneity of rpoB in Mycobacterium tuberculosis found at low pH. Journal of Antimicrobial Chemotherapy, , - .
    • Al-Balas Q, Anthony NG, Al-Jaidi1 B, Alnmir A, Abbott G, Brown AK, Taylor RC, Besra GS, McHugh TD, Gillespie SH, Johnston BF, Mackay SP, Coxon GD (2009). Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the b-Ketoacyl-ACP Synthase mtFabH. PLoS ONE, 4(5), e5617 - .
    • Naqvi SM, Jenkins C, McHugh TD, Balakrishnan I (2009). Identification of the qnr family in Enterobacteriaceae in clinical practice.. Journal of Antimicrobial Chemotherapy, 63(4), 830 - 832.
    • Pope CF, O'Sullivan DM, McHugh TD, Gillespie SH (2009). A Practical Guide to Measuring Mutation Rates in Antibiotic Resistance (vol 52, pg 1209, 2008). ANTIMICROB AGENTS CH, 53(1), 339 - 339. doi:10.1128/AAC.01441-08

    2008

    • Pope CF, O Sullivan DM, McHugh TD, Gillespie SH (2008). Measuring Mutation Rates in Antibiotic Resistance: A Practical Guide. Antimicrobial Agents and Chemotherapy, 52(4), 1209 - 1214.
    • Breen RA, Barry SM, Smith CJ, Shorten RJ, Dilworth JP, Cropley I, McHugh TD, Gillespie SH, Janossy G, Lipman MC (2008). The Clinical Application of a Rapid Lung-Orientated TB Immunoassay in Individuals with Possible Tuberculosis.. Thorax, 63(1), 67 - 71.
    • Pope CF, Gillespie SH, Pratten J, McHugh TD (2008). Fluoroquinolone-resistant mutants of Burkholderia cepacia. Antimicrobial Agents and Chemotherapy, 52(3), 1201 - 1203.
    • Pope CF, O'Sullivan DM, McHugh TD, Gillespie SH (2008). A practical guide to measuring mutation rates in antibiotic resistance. ANTIMICROB AGENTS CH, 52(4), 1209 - 1214. doi:10.1128/AAC.01152-07
    • Davies AP, Dhillon AP, Young M, Henderson B, McHugh TD, Gillespie SH (2008). Resuscitation-promoting factors are expressed in Mycobacterium tuberculosis-infected human tissue. Tuberculosis, 88(5), 462 - 468.
    • Perrin FMR, Breen RAM, McHugh TD, Gillespie SH, Lipman MCI (2008). IF PATIENTS WITH PULMONARY TUBERCULOSIS ON TREATMENT STOP EXPECTORATING SPUTUM, ARE THEY GENUINELY CULTURE NEGATIVE?.
    • O'Sullivan DM, McHugh TD, Gillespie SH (2008). The effect of oxidative stress on the mutation rate of Mycobacterium tuberculosis with impaired catalase/peroxidase function.. Journal of Antimicrobial Chemotherapy, , - .
    • O'Sullivan DM, Hinds J, Butcher PD, Gillespie SH, McHugh TD (2008). Mycobacterium tuberculosis DNA repair in response to subinhibitory concentrations of ciprofloxacin. Journal of Antimicrobial Chemotherapy, , - .

    2007

    • Breen RAM, Dunleavy A, Perrin F, Mchugh TD, Gillespie S, Cropley I, Lipman MCI (2007). Rapid immuno-diagnosis active extrapulmonary tuberculosis.
    • O'Sullivan DM, Sander C, Shorten RJ, Gillespie SH, Hill AV, McHugh TD, McShane H, Tchilian EZ (2007). Evaluation of liquid culture for quantitation of Mycobacterium tuberculosis in murine models.. Vaccine, 25(49), 8203 - 8205.
    • Pope CF, McHugh TD, Pratten J, Gillespie SH (2007). Measuring bacterial fitness.
    • Williams KJ, Ling CL, Jenkins C, Gillespie SH, McHugh TD (2007). A paradigm for the molecular identification of Mycobacterium species in a routine diagnostic laboratory. Journal of Medical Microbiology, 56(part 5), 598 - 602.
    • Perrin FM, Lipman MC, McHugh TD, Gillespie SH (2007). Biomarkers of treatment response in clinical trials of novel antituberculosis agents.. Lancet Infect Dis, 7(7), 481 - 490.
    • Perrin FMR, Lipman MCI, McHugh TD, Gillespie SH (2007). Biomarkers of treatment response in clinical trials of novel anti-TB agents. The Lancet Infectious Diseases, 7, 481 - 490.

    2006

    • Paterson PJ, Seaton S, McHugh TD, McLaughlin J, Potter M, Prentice HG, Kibbler CC (2006). Validation and clinical application of molecular methods for the identification of molds in tissue. Clinical Infectious Diseases, 42(1), 51 - 56.
    • Creer DD, Dilworth JP, Gillespie SH, Johnston AR, Johnston SL, Ling C, Patel S, Sanderson G, Wallace PG, McHugh TD (2006). Aetiological role of viral and bacterial infections in acute adult lower respiratory tract infection (LRTI) in primary care. Thorax, 61(1), 75 - 79. doi:10.1136/thx.2004.027441
    • Uriyo J, Gosling RD, Maddox V, Sam NE, Schimana W, Gillespie SH, McHugh TD (2006). Prevalences of Pneumocystis jiroveci, Mycobacterium tuberculosis and Streptococcus pneumoniae infection in children with severe pneumonia, in a tertiary referral hospital in northern Tanzania.. Annals of Tropical Medicine and Parasitology, 100(3), 245 - 249.
    • Cullen MM, Sam NE, Kanduma EG, McHugh TD, Gillespie SH (2006). Direct detection of heteroresistance in Mycobacterium tuberculosis using molecular techniques.. Journal of Medical Microbiology, 55(8), 1157 - 1158.
    • McHugh TD, Pope CF (2006). Strand displacement amplification. In Jurgen Fuchs MP (Ed.), Encyclopedia of Medical Genomics and Proteomics (pp. - ). : Taylor Francis.
    • Paterson PJ, Seaton S, McHugh TD, McLaughlin J, Potter M, Prentice HG, Kibbler CC (2006). Validation and clinical application of molecular methods for the identification of molds in tissue.. Clin Infect Dis, 42(1), 51 - 56. doi:10.1086/498111

    2005

    • Gillespie SH, Basu S, Dickens AL, O'Sullivan DM, McHugh TD (2005). Effect of subinhibitory concentrations of ciprofloxacin on Mycobacterium fortuitum mutation rates. Journal of Antimicrobial Chemotherapy, 56(2), 344 - 348. doi:10.1093/jac/dki191
    • Shorten RJ, Gillespie SH, Sule O, Lipman M, McHugh TD (2005). Molecular strain typing of M. tuberculosis isolates from a suspected outbreak involving a faulty bronchoscope. J HOSP INFECT, 61(1), 86 - 87. doi:10.1016/j.jhin.2004.12.013
    • Perrin FMR, Parsons YN, Breen RAM, Islam J, McHugh TD, Lipman MCI, Gillespie SH (2005). Messenger RNA as a marker of treatment response in pulmonary tuberculosis.
    • Jenkins C, Claxton AP, Shorten RJ, McHugh TD, Gillespie SH (2005). Rifampicin resistance in tuberculosis outbreak, London, England.. Emerging Infectious Diseases, 11(6), 931 - 934.
    • O'Sullivan DM, McHugh TD, Gillespie SH (2005). Analysis of rpoB and pncA mutations in the published literature:an insight into the role of oxidative stress inMycobacterium tuberculosis evolution?. Journal of Antimicrobial Chemotherapy, 55(5), 674 - 679.
    • Shorten RJ, Gillespie SH, Sule O, Lipman M, McHugh TD (2005). Molecular strain typing of M. tuberculosis isolates from a suspected outbreak involving a faulty bronchoscope. Journal of Hospital Infection, 61(1), 86 - 87. doi:10.1016/jhin.2004.12.013
    • Dale JW, Bothamley GH, Drobniewski F, Gillespie SH, McHugh TD, Pitman R (2005). Origins and properties of Mycobacteriumtuberculosis isolates in London. Journal of Medical Microbiology, 54(6), 575 - 582.
    • Gillespie SH, Gosling RD, Uiso L, Sam NE, Kanduma EG, McHugh TD (2005). Early bactericidal activity of a moxifloxacin and isoniazid combination in smear-positive pulmonary tuberculosis. Journal of Antimicrobial Chemotherapy, 56(6), 1169 - 1171.
    • Paterson PJ, Seaton S, Yeghen T, McHugh TD, McLaughlin J, Hoffbrand AV, Kibbler CC (2005). Molecular confirmation of invasive infection caused by Chaetomium globosum.. J Clin Pathol, 58(3), 334 - .
    • Paterson PJ, Seaton S, Yeghen T, McHugh TD, McLaughlin J, Hoffbrand AV, Kibbler CC (2005). Molecular confirmation of invasive infection caused byChaetomium globosum. Journal of Clinical Pathology, 58(3), 334 - 334.
    • McHugh TD, Batt SL, Shorten RJ, Gosling RD, Uiso L, Gillespie SH (2005). Mycobacterium tuberculosis lineage: a naming of the parts.. Tuberculosis, 85(3), 127 - 136. doi:10.1016/j.tube.2004.06.002
    • Batt SL, Charalambous BM, McHugh TD, Martin S, Gillespie SH (2005). Novel PCR-restriction fragement length polymorphism method to determine serotypes or serogroups of Streptococcus pneumoniae isolates. Journal of Clinical Microbiology, 43(6), 2656 - 2661. doi:10.1128/JCM.43.6.2656-2661.2005
    • Perrin FM, Breen RA, Lipman MC, Shorten RJ, Gillespie SH, McHugh TD (2005). Is there a relationship between Mycobacterium tuberculosis strain type and TB paradoxical reaction?. Thorax, 60(8), 706 - 707. doi:10.1136/thx.2005.044321

    2004

    • Perrin FMR, Shorten RJ, Breen RAM, McHugh TD, Lipman MCI (2004). Is there an association between paradoxical reactions and mycobacterium tuberculosis strain type?.
    • McHugh TD, Pope CF, Ling CL, Patel P, Billington OJ, Gosling RD, Lipman MC, Gillespie SH (2004). Prospective evaluation of BDProbeTec strand displacement amplification (SDA) system for diagnosis of tuberculosis in non-respiratory and respiratory samples. Journal of Medical Microbiology, 53(12), 1215 - 1219. doi:10.1099/jmm.0.45780-0
    • Charalambous BM, McHugh TD (2004). Immunological principles of vaccination (Theory). In Jong EC, Zuckerman JD (Ed.), Travelers' Vaccines. Section 1: Vaccine Immunology (pp. 1 - 19). : BC Decker Inc.

    2003

    • Huggett JF, McHugh TD, Zumla A (2003). Tuberculosis: amplification-based clinical diagnostic techniques. The International Journal of Biochemistry and Cell Biology, 35(10), 1407 - 1412.
    • Dale JW, Al Ghusein H, Butcher P, Dickens A, Drobniewski F, Forbes KJ, Gillespie SH, Lamprecht D, McHugh TD, Pitman R, Rastogi N, Smith AT, Sola C, Yesilkaya H (2003). Evolutionary relationships among strains of Mycobacterium tuberculosis with few copies of IS6110. Journal of Applied Microbiology, 185, 2555 - 2562.
    • Gillespie SH, McHugh TD (2003). Criteria for identification of cross-contamination of cultures of Mycobacterium tuberculosis in routine microbiology laboratories - Authors' reply (reference 4). J CLIN MICROBIOL, 41(5), 2269 - 2270.
    • Maguire H, Dale JW, McHugh TD, Butcher PD, Gillespie SH, Costetsos A, Al-Ghusein H, Holland R, Dickens A, Marston L, Wilson P, Pitman R, Strachan D, Drobniewski FA, Banerjee DK (2003). Molecular epidemiology of tuberculosis in London 1995-7 showing low rate of active transmission. J CLIN PATHOL-MOL PA, 56(2), 121 - 126.
    • Gillespie SH, McHugh TD (2003). Criteria for identification of cross-contamination of cultures of Mycobacterium tuberculosis in routine microbiology laboratories (letter). Journal of Clinical Microbiology, 41(5), 2269 - 2270.
    • Kanduma E, McHugh TD, Gillespie SH (2003). Molecular methods for Mycobacterium tuberculosis strain typing: a users guide. Journal of Applied Microbiology, 94(5), 781 - 791.

    2002

    • Ruddy M, McHugh TD, Dale JW, Banerjee D, Maguire H, Wilson P, Drobniewski F, Butcher P, Gillespie SH (2002). Examination of the rate of unrecognized cross-contamination with Mycobacterium tuberculosis in London microbiology laboratories. Journal of Clinical Microbiology, 40(11), 4100 - 4104.
    • Maguire H, Dale JW, McHugh TD, Butcher PD, Gillespie SH, Costetsos A, Al Ghusein H, Holland R, Dickens A, Marston L, Wilson P, Pitman R, Strachan D, Drobniewski FA, Banerjee DK (2002). Molecular epidemiology of tuberculosis in London 1995-7 showing low rate of active transmission. THORAX, 57(7), 617 - 622.
    • Gillespie SH, Billington OJ, Breathnach A, McHugh TD (2002). Multiple drug resistant tuberculosis: evidence for changing fitness on passage through human hosts. Microbial Drug Resistance, 8, 1 - 7.
    • Gillespie SH, Billington OJ, Breathnach A, McHugh TD (2002). Multiple drug-resistant Mycobacterium tuberculosis: evidence for changing fitness following passage through human hosts.. Microb Drug Resist, 8(4), 273 - 279. doi:10.1089/10766290260469534
    • Melzer M, Brown TJ, French GL, Dickens A, McHugh TD, Bagg LR, Storring RA, Lacey S (2002). Molecular analysis of drug resistant TB. THORAX, 57(6), 562 - 563.

    2000

    • McHugh TD (2000). Application of SSCP to identification of resistance mutations. In Gillespie SH (Ed.), Antibiotic Resistance Methods and Protocols (pp. - ). : The Humana Press Inc.
    • Gillespie SH, Dickens A, McHugh TD (2000). False molecular clusters due to non-random association of IS6110 with Mycobacterium tuberculosis. Journal of Clinical Microbiology, 38(6), 2081 - 2086.
    • Davies AP, Billington OJ, Bannister BA, Weir WRC, McHugh TD, Gillespie SH (2000). Comparison of fitness of two isolates of Mycobacterium tuberculosis, one of which had developed mulit-drug resistance during the course of treatment. Journal of Infection, 41(2), 184 - 187.
    • Davies AP, Billington OJ, McHugh TD, Mitchison DA, Gillespie SH (2000). Comparison of phenotypic and genotypic methods for pyrazinamide susceptibility testing with Mycobacterium tuberculosis. Journal of Clinical Microbiology, 38(10), 3686 - 3688.
    • Creer DD, McHugh TD, Laqueur S, Wallace PG, Dilworth JP (2000). The relationship of antibiotics in acute adult lower respiratory tract infection (LRTI) to clinical presentation and outcome. THORAX, 55, A71 - A71.

    1999

    • Billington OJ, McHugh TD, Gillespie SH (1999). Physiological cost of rifampin resistance induced in vitro in Mycobacterium tuberculosis.. Antimicrobial Agents and Chemotherapy, 43(8), 1866 - 1869.

    1998

    • Gillespie SH, Newport LE, McHugh TD (1998). IS6110 homologs are present in multiple copies in mycobacteria other than tuberculosis-causing mycobacteria - Authors' reply. J CLIN MICROBIOL, 36(3), 854 - 854.
    • McHugh TD, Gillespie SH (1998). Nonrandom association of IS6110 and Mycobacterium tuberculosis: implications for molecular epidemiological studies.. Journal of Clinical Microbiology, 36(5), 1410 - 1413.

    1997

    • Gillespie SH, McHugh TD, Newport LE (1997). Specificity of IS6110-based amplification assays for Mycobacterium tuberculosis complex.. Journal of Clinical Microbiology, 35(3), 799 - 801.
    • Gillespie SH, McHugh TD, Hughes JE, Dickens A, Kyi MS, Kelsey M (1997). An outbreak of penicillin resistant Streptococcus pneumoniae investigated by a polymerase chain reaction based genotyping method.. Journal of Clinical Pathology, 50(10), 847 - 851.
    • Gillespie SH, McHugh TD (1997). Monitoring the therapy of pulmonary tuberculosis by nested polymerase chain reaction.. Journal of Infection, 35(5), 324 - 325.
    • Gillespie SH, McHugh TD, Ayres H, Dickens A, Efstratiou A, Whiting GC (1997). Allelic variation in Streptococcus pneumoniae autolysin (N-acetyl muramoyl-L-alanine amidase).. Infection and Immunity, 65(9), 3936 - 3938.
    • Gillespie SH, McHugh TD (1997). The genus mycobacteria. In Emmerson AM, Hawkey PM, Gillespie SH (Ed.), Principles and practice of Clinical Bacteriology (pp. - ). : John Wiley.
    • McHugh TD, Newport LE, Gillespie SH (1997). IS6110 homologs are present in multiple copies in mycobacteria other than tuberculosis-causing mycobacteria.. Journal of Clinical Microbiology, 35(7), 1769 - 1771.
    • Gillespie SH, McHugh TD (1997). The biological cost of antimicrobial resistance.. Trends in Microbiology, 5(9), 337 - 339.
    • McHugh TD, Bathgate T, Mangan J, Johnson JD, Holliman RE, Butcher PD (1997). Recognition of tissue cyst-specific antigens in reactivating toxoplasmosis.. Journal of Medical Microbiology, 46(7), 587 - 595.

    1995

    • KENT L, MCHUGH TD, BILLINGTON O, DALE JW, GILLESPIE SH (1995). DEMONSTRATION OF HOMOLOGY BETWEEN IS6110 OF MYCOBACTERIUM-TUBERCULOSIS AND DNAS OF OTHER MYCOBACTERIUM SPP (VOL 33, PG 2290, 1995). J CLIN MICROBIOL, 33(11), 3082 - 3082.
    • McHugh TD, Ramsay AR, James EA, Mognie R, Gillespie SH (1995). Pitfalls of PCR: misdiagnosis of cerebral nocardia infection.. The Lancet, 346, 1436 - .
    • Kent L, McHugh TD, Billington O, Dale JW, Gillespie SH (1995). Demonstration of homology between IS6110 of Mycobacterium tuberculosis and DNAs of other Mycobacterium spp.?. Journal of Clinical Microbiology, 33(9), 2290 - 2293.

    1994

    • McHugh TD, Jenkins T, Greenwood R, McLaren DJ (1994). The migration and attrition of Strongyloides ratti in naive and sensitized rats. Journal of Helminthology, 68(2), 143 - 148.
    • McHugh TD, Holliman RE, Butcher PD (1994). The in vitro model of tissue cyst formation in Toxoplasma gondii.. Parasitology Today, 10(7), 281 - 285.

    1993

    • McHugh TD, Gbewonyo A, Johnson JD, Holliman RE, Butcher PD (1993). Development of an in vitro model of Toxoplasma gondii cyst formation.. FEMS Microbiology Letters, 114(3), 325 - 332.

    1991

    • KATELARIS PH, MCHUGH TD, CARNABY S, CEVALLOS AM, CHAR S, FARTHING MJG (1991). BILE MODULATES GENOTYPIC AND PHENOTYPIC CHARACTERISTICS OF GIARDIA-LAMBLIA. GUT, 32(10), A1260 - A1260.
    • CARNABY S, MCHUGH TD, FARTHING MJG (1991). DNA FINGERPRINTING OF GIARDIA-LAMBLIA WITH THE M13 BACTERIOPHAGE GENOME. GUT, 32(5), A596 - A597.
    • CARNABY S, MCHUGH TD, KATELARIS PH, FARTHING MJG (1991). GENOMIC EVIDENCE FOR MULTIPLE STRAIN INVOLVEMENT IN GIARDIA-LAMBLIA INFECTION. GUT, 32(5), A563 - A563.
    • CEVALLOS AM, MCHUGH TD, CARNABY S, FARTHING MJG (1991). PHENOTYPIC AND GENOTYPIC VARIATION IN GIARDIA-LAMBLIA. SAUDI MED J, 12(4), 285 - 289.

    1990

    • MORRISON AM, MCHUGH TD, BUTCHER PD, CEVALLOS AM, FARTHING MJG (1990). HEAT-SHOCK PROTEINS IN HUMAN AND ANIMAL GIARDIA LAMBLIA ISOLATES. CLIN SCI, 78(4), P38 - P38.
    • FARTHING MJG, BUTCHER PD, CEVALLOS AM, MORRISON AM, MCHUGH TD (1990). PHENOTYPIC AND GENOTYPIC VARIATION IN GIARDIA-LAMBLIA. PEDIATR RES, 27(5), 537 - 537.
    • MCHUGH TD, YAMSON PP, FARTHING MJG (1990). GIARDIA LAMBLIA - TEMPORAL ANALYSIS OF ANTIGEN RECOGNITION. GUT, 31(5), A610 - A610.

    1989

    • McHugh TD, Jenkins T, McLaren DJ (1989). Strongyloides ratti: studies of cutaneous reactions elicited in naive and sensitized rats and of changes in surface antigenicity of skin-penetrating larvae.. Parasitology, 98(1), 95 - 103.

    • Perrin FMR, Breen RAM, McHugh TD, Gillespie SH, Lipman MCI (). Are patients on treatment for pulmonary TB who stop expectorating sputum genuinely culture negative?. Thorax, , - .