Prof Nigel Klein

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Personal Profile

Name: Nigel Klein Email: n.klein@ucl.ac.uk
Title: Prof Tel: 0207 905 2891
Department: ICH Infect, Imm, Infla. & Physio Med Fax: 0207 813 8494
Position: Professor of Infectious Disease and Immunology Address: 30 guilford street, , London, WC1N 1EH
Research Domain: Global Health, Infection, Immunology & Inflammation, Personalised Medicine, Populations & Lifelong Health Web Page:  

Profile

Research Description

Main research interests include pediatric sepsis, meningitis, HIV, the role of infection in vascular disease, hospital acquired infections.

Research Activities

Childhood global and focal ischaemia

Diarrhoea in Children

HIV

Investigation and prevention of perinatally acquired brain injury

Mechanisms regulating lymphocyte differentiation i

Paediatric and Developmental Pathology

Stroke and cerebrovascular disease in children

hospital acquired infections

meningitis

pediatric sepsis

the role of infection in vascular disease

Education Description

UCL Collaborators

Prof Dame Linda Partridge; Prof David Gems; Dr Chris Clark; Prof John Greenwood; Prof Faraneh Vargha-Khadem; Prof Peter Coveney; Prof Amanda Mocroft; Prof Alan Phillips; Prof Mala Maini; Prof Neil Sebire; Dr Vijeya Ganesan; Prof Donald Peebles; Prof Martin Brown; Dr Michelle De Haan; Prof Arne Akbar; Prof Dominic Withers; Prof Robin Callard; Dr Paul Brogan; Dr Alex Hogan; Prof Andrew Phillips; Prof Deenan Pillay; Dr Mona Bajaj-Elliot; Prof Fenella Kirkham; Prof Agostino Pierro; Prof David Gadian; Prof Surjit Kaila Singh Srai; Prof Greg Towers

External Collaborators

Publications

    2014

    • D'Arcy N, Cloutman-Green E, Klein N, Spratt DA (2014). Environmental viral contamination in a pediatric hospital outpatient waiting area: Implications for infection control.. Am J Infect Control, 42(8), 856 - 860. doi:10.1016/j.ajic.2014.04.014
    • James C, Bajaj-Elliott M, Syngelaki A, Klein N, Nicolaides K, Peebles D (2014). 8.4 Serum beta defensin concentration in the first trimester is related to genotype, and is higher in women who develop PPROM and deliver before 34 weeks.. Arch Dis Child Fetal Neonatal Ed, 99 Suppl 1, A12 - . doi:10.1136/archdischild-2014-306576.33
    • James C, Bajaj-Elliott M, Syngelaki A, Klein N, Nicolaides K, Peebles D (2014). Systemic innate immune response in the first trimester is related to DEFB1 genotype, and is distinct in women who develop PPROM and deliver before 34 weeks of gestation. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 121(7), E11 - E11.
    • Musiime V, Kayiwa J, Wavamunno P, Mirembe G, Kityo C, Cook A, Kenny J, Walker SA, Gibb DM, Zangata D, Kabamba D, Mulenga V, Nansubuga C, Komunyena J, Asiimwe AR, Kekitiinwa A, Arach B, Abongomera G, Klein N (2014). Anthropometric measurements and lipid profiles to detect early lipodystrophy in antiretroviral therapy experienced HIV-infected children in the CHAPAS-3 trial. Antiviral Therapy, 19(3), 269 - 276. doi:10.3851/IMP2695
    • D'Arcy N, Spratt DA, Cloutman-Green E, Klein N, Lai KM, Margaritis D (2014). Potential exposure of children to environmental microorganisms in indoor healthcare and educational settings. Indoor and Built Environment, 23(3), 467 - 473. doi:10.1177/1420326X14527018
    • Fisher J, Yan M, Heuijerjans J, Carter L, Abolhassani A, Frosch J, Wallace R, Flutter B, Hubank M, Klein N, Callard R, Gustafsson K, Anderson J (2014). Neuroblastoma killing properties of V-delta 2 and V-delta2 negative gamma delta T cells following expansion by artificial antigen presenting cells.. Clin Cancer Res, , - . doi:10.1158/1078-0432.CCR-13-3464
    • Eleftheriou D, Brogan PA, Levin M, Shingadia D, Klein NJ, Tulloh R (2014). Management of Kawasaki disease. Archives of Disease in Childhood, 99(1), 74 - 83. doi:10.1136/archdischild-2012-302841
    • Tann CJ, Nkurunziza P, Nakakeeto M, Oweka J, Kurinczuk JJ, Were J, Nyombi N, Hughes P, Willey BA, Elliott AM, Robertson NJ, Klein N, Harris KA (2014). Prevalence of Bloodstream Pathogens Is Higher in Neonatal Encephalopathy Cases vs. Controls Using a Novel Panel of Real-Time PCR Assays.. PLoS One, 9(5), e97259 - . doi:10.1371/journal.pone.0097259
    • Cloutman-Green E, Kalaycioglu O, Wojani H, Hartley JC, Guillas S, Malone D, Gant V, Grey C, Klein N (2014). The important role of sink location in handwashing compliance and microbial sink contamination.. Am J Infect Control, 42(5), 554 - 555. doi:10.1016/j.ajic.2013.12.020
    • Jones HE, Copland A, Klein N, Dixon G, Hamstra HJ, Van der Ley P, Cohen J, Brown J (2014). LOS oligosaccharide modification enhances dendritic cell responses to meningococcal native outer membrane vesicles expressing a non-toxic lipid A. Cellular Microbiology, 16(4), 519 - 534. doi:10.1111/cmi.12231
    • Sandgaard KS, Lewis J, Klein N, Callard R, Adams S (2014). Antiretroviral therapy increases thymic output in children with HIV. AIDS, 28(2), 209 - 214. doi:10.1097/QAD.0000000000000063
    • Epstein M, Barenco M, Klein N, Hubank M, Callard RE (2014). Revealing Individual Signatures of Human T Cell CDR3 Sequence Repertoires with Kidera Factors.. PLoS One, 9(1), e86986 - . doi:10.1371/journal.pone.0086986
    • Omoyinmi E, Melo Gomes S, Standing A, Rowczenio DM, Eleftheriou D, Klein N, Aróstegui JI, Lachmann HJ, Hawkins PN, Brogan PA (2014). Brief Report: Whole-Exome Sequencing Revealing Somatic NLRP3 Mosaicism in a Patient With Chronic Infantile Neurologic, Cutaneous, Articular Syndrome.. Arthritis Rheumatol, 66(1), 197 - 202. doi:10.1002/art.38217
    • James CP, Bajaj-Elliott M, Syngelaki A, Klein N, Nicolaides K, Peebles DM (2014). Systemic Innate Immune Response in the First Trimester Is Related to DEFB1 Genotype, and Is Distinct in Women Who Develop PPROM and Deliver before 34 Weeks of Gestation. REPRODUCTIVE SCIENCES, 21(3), 239A - 239A.

    2013

    • Nanthapisal S, Eleftheriou D, Hong Y, Klein N, Brogan PA (2013). Behcet's disease in children: The Great Ormond Street Hospital experience. PRESSE MEDICALE, 42(4), 691 - 691. doi:10.1016/j.lpm.2013.02.094
    • Dommett R, Chisholm J, Turner M, Bajaj-Elliott M, Klein NJ (2013). Mannose-binding lectin genotype influences frequency and duration of infectious complications in children with malignancy.. J Pediatr Hematol Oncol, 35(1), 69 - 75. doi:10.1097/MPH.0b013e31827076e5
    • James CP, Klein N, Bajaj-Elliott M, Peebles D (2013). Progesterone Modulates Cervical Antimicrobial Immunity..
    • James C, Bajaj-Elliott M, Syngelaki A, Klein N, Nicolaides K, Peebles D (2013). Association of human beta defensin-1 (DEFB1) polymorphisms and in vivo protein expression: first population-based analysis.
    • Gibbons DL, Fleming PF, Virasami A, Michel M-L, Sebire N, Costeloe K, Carr R, Klein N, Hayday AC (2013). Interleukin-8 (CXCL8) production is the major effector potential of T cells in human neonates.
    • (2013). 47th Annual Meeting of the Association for European Paediatric Cardiology,AEPC with joint sessions with the Japanese Society of Pediatric Cardiology and Cardiac Surgery and Asia–Pacific Pediatric Cardiac Society. doi:10.1017/S104795111300036X
    • Eaton S, Klein N, Ong E, Pierro A (2013). Authors' reply: Randomized clinical trial of glutamine-supplemented versus standard parenteral nutrition in infants with surgical gastrointestinal disease (Br J Surg 2012; 99: 929-938).. Br J Surg, 100(6), 841 - 842. doi:10.1002/bjs.9126
    • Songane MJ, Kuehne S, Hussain H, Klein N, Minton N, Allan E, Bajaj-Elliott M (2013). Mechanism(s) involved in Clostridium difficile-mediated Inflammasome activation.
    • Rosser EC, Tonon S, Doyle R, Bosma A, Carter NA, Harris KA, Klein N, Mauri C (2013). Gut-microbiota induced IL-1 beta and IL-6 control the differentiation of regulatory B cells.
    • Fitzgerald F, Doyle R, Klein N, Harris K, Alber D (2013). Short communication: Evidence that microbial translocation occurs in HIV-infected children in the united kingdom. AIDS Research and Human Retroviruses, 29(12), 1589 - 1593. doi:10.1089/aid.2013.0097
    • Klein N, Sefe D, Jacobsen M, Jones H, Mosconi I, Zanchetta M, De Rossi A, Castro H, Walker AS, Gibb DM, Bernardi S, Pillay D, Giaquinto C (2013). The Immunological and Virological Consequences of Planned Treatment Interruptions in Children with HIV Infection. PLoS ONE, 8(10), - . doi:10.1371/journal.pone.0076582
    • Gaudart J, Cloutman-Green E, Guillas S, D'Arcy N, Hartley JC, Gant V, Klein N (2013). Healthcare Environments and Spatial Variability of Healthcare Associated Infection Risk: Cross-Sectional Surveys. PLOS ONE, 8(9), - . doi:10.1371/journal.pone.0076249
    • Jones HE, Copland A, Hamstra HJ, Cohen J, Brown J, Klein N, Ley PV, Dixon G (2013). LOS oligosaccharide modification enhances dendritic cell responses to meningococcal native outer membrane vesicles expressing a non toxic lipid A.. Cell Microbiol, , - . doi:10.1111/cmi.12231
    • Eleftheriou D, Levin M, Shingadia D, Tulloh R, Klein N, Brogan P (2013). Management of Kawasaki disease.. Arch Dis Child, , - . doi:10.1136/archdischild-2012-302841
    • Sandgaard KS, Lewis J, Adams S, Klein N, Callard R (2013). Antiretroviral therapy increases thymic output in children with HIV.. AIDS, , - . doi:10.1097/QAD.0000000000000063
    • Eleftheriou D, Dillon MJ, Tullus K, Marks SD, Pilkington CA, Roebuck DJ, Klein NJ, Brogan PA (2013). Systemic Polyarteritis Nodosa in the Young: A Single-Center Experience Over Thirty-Two Years. ARTHRITIS AND RHEUMATISM, 65(9), 2476 - 2485. doi:10.1002/art.38024
    • Jacobsen MC, Manunta MDI, Pincott ES, Klein NJ, Burch M (2013). Cytomegalovirus Specific Immunity in Paediatric Cardiac Transplantation.
    • Kwan A, Hubank M, Rashid A, Klein N, Peters MJ (2013). Transcriptional instability during evolving sepsis may limit biomarker based risk stratification.. PLoS One, 8(3), e60501 - . doi:10.1371/journal.pone.0060501
    • Musiime V, Cook A, Bakeera-Kitaka S, Vhembo T, Lutakome J, Keishanyu R, Prendergast AJ, Lubwama S, Robertson V, Hughes P, Nathoo K, Munderi P, Klein N, Musoke P, Gibb DM, ARROW Trial Team (2013). Bacteremia, causative agents and antimicrobial susceptibility among HIV-1-infected children on antiretroviral therapy in Uganda and Zimbabwe.. Pediatr Infect Dis J, 32(8), 856 - 862. doi:10.1097/INF.0b013e31828c3991
    • James CP, Bajaj-Elliott M, Syngelaki A, Klein N, Nicolaides K, Peebles D (2013). Variation in Beta Defensin 1 Genotype Is Associated with Preterm Birth..

    2012

    • Pramanik N, Lucas M, Bryant C, Elliott MB, Klein N (2012). Enteropathogenic Escherichia coli engages in temporal regulation of the inflammasome by interaction with NLRC4 and NALP3.
    • Jones HE, Klein N, Dixon GL (2012). Human dendritic cell culture and bacterial infection.. Methods Mol Biol, 799, 217 - 235. doi:10.1007/978-1-61779-346-2_14
    • Ong EG, Eaton S, Wade AM, Horn V, Losty PD, Curry JI, Sugarman ID, Klein NJ, Pierro A, SIGN Trial Group (2012). Randomized clinical trial of glutamine-supplemented versus standard parenteral nutrition in infants with surgical gastrointestinal disease.. Br J Surg, 99(7), 929 - 938. doi:10.1002/bjs.8750
    • Azizia M, Lloyd J, Allen M, Klein N, Peebles D (2012). Immune status in very preterm neonates.. Pediatrics, 129(4), e967 - e974. doi:10.1542/peds.2011-1579
    • Lewis J, Walker AS, Castro H, De Rossi A, Gibb DM, Giaquinto C, Klein N, Callard R (2012). Age and CD4 Count at Initiation of Antiretroviral Therapy in HIV-Infected Children: Effects on Long-term T-Cell Reconstitution. JOURNAL OF INFECTIOUS DISEASES, 205(4), 548 - 556. doi:10.1093/infdis/jir787
    • van de Vijver E, Maddalena A, Sanal O, Holland SM, Uzel G, Madkaikar M, de Boer M, van Leeuwen K, Koker MY, Parvaneh N, Fischer A, Law SKA, Klein N, Tezcan FI, Unal E, Patiroglu T, Belohradsky BH, Schwartz K, Somech R, Kuijpers TW, Roos D (2012). Hematologically important mutations: Leukocyte adhesion deficiency (first update). BLOOD CELLS MOLECULES AND DISEASES, 48(1), 53 - 61. doi:10.1016/j.bcmd.2011.10.004
    • Bishay M, Retrosi G, Horn V, Cloutman-Green E, Harris K, de Coppi P, Klein N, Eaton S, Pierro A (2012). Septicaemia due to enteric organisms is a later event in surgical infants requiring parenteral nutrition.. Eur J Pediatr Surg, 22(1), 50 - 53. doi:10.1055/s-0031-1287853
    • Albar D, Alviani C, Harris K, Klein N, Peebles D (2012). Bacteria Identified by PCR in Fetal Membranes Following Preterm Labour Associated with Increased Toll Receptor Expression. REPRODUCTIVE SCIENCES, 19(S3), 121A - 121A.
    • Masi S, Klein N, Deanfield JE, D'Aiuto F, Salpea K, Humphries SE, Taddei S, Nightingale CM, Cook DG, Whincup PH, Day INM, Guthrie P, Rumley A, Lowe GDO, Von Zglinicki T (2012). Inflammation and not cardiovascular risk factors is associated with short leukocyte telomere length in 13-to 16-year-old adolescents. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(8), 2029 - 2034. doi:10.1161/ATVBAHA.112.250589
    • Eleftheriou D, Ganesan V, Hong Y, Klein NJ, Brogan PA (2012). Endothelial injury in childhood stroke with cerebral arteriopathy: a cross sectional study.. Neurology, , - .
    • Wojgani H, Kehsa C, Cloutman-Green E, Gray C, Gant V, Klein N (2012). Hospital Door Handle Design and Their Contamination with Bacteria: A Real Life Observational Study. Are We Pulling against Closed Doors?. PLOS ONE, 7(10), - . doi:10.1371/journal.pone.0040171
    • Milioris E, Iebba V, Klein NJ, Steevels T, Simmons A, Bajaj-Elliott M (2012). The impact of NOD2 3020insC mutation in microbial-driven host innate immunity.
    • Pramanik N, Lucas M, Klein N, Bryant C, Bajaj-Elliott M (2012). Enteropathogenic Escherichia coli engages in temporal regulation of the inflammasome by interaction with NLRC4 and NALP3.
    • Lewis J, Walker AS, Castro H, Rossi AD, Gibb DM, Giaquinto C, Klein N, Callard R (2012). Reply to Zhang, Poznansky and Crumpacker.. J Infect Dis, , - . doi:10.1093/infdis/jis388
    • Lewis J, Walker AS, Klein N, Callard R (2012). CD31+ cell percentage correlation with speed of CD4+ T-cell count recovery in HIV-infected adults is reversed in children: higher thymic output may be responsible.. Clin Infect Dis, 55(2), 304 - 307. doi:10.1093/cid/cis374
    • Masi S, Nightingale CM, Day IN, Guthrie P, Rumley A, Lowe GD, von Zglinicki T, D'Aiuto F, Taddei S, Klein N, Salpea K, Cook DG, Humphries SE, Whincup PH, Deanfield JE (2012). Inflammation and not cardiovascular risk factors is associated with short leukocyte telomere length in 13- to 16-year-old adolescents.. Arterioscler Thromb Vasc Biol, 32(8), 2029 - 2034. doi:10.1161/ATVBAHA.112.250589
    • Fabbri-Arrigoni FI, Clarke L, Wang G, Charakida M, Ellins E, Halliday N, Brogan PA, Deanfield JE, Halcox JP, Klein N (2012). Levels of circulating endothelial cells and colony-forming units are influenced by age and dyslipidemia.. Pediatr Res, 72(3), 299 - 304. doi:10.1038/pr.2012.76
    • Prendergast A, O'Callaghan M, Menson E, Hamadache D, Walters S, Klein N, Goulder P (2012). Factors Influencing T Cell Activation and Programmed Death 1 Expression in HIV-Infected Children. AIDS RESEARCH AND HUMAN RETROVIRUSES, 28(5), 465 - 468. doi:10.1089/aid.2011.0113
    • Hong Y, Eleftheriou D, Hussain AA, Price-Kuehne FE, Savage CO, Jayne D, Little MA, Salama AD, Klein NJ, Brogan PA (2012). Anti-neutrophil cytoplasmic antibodies stimulate release of neutrophil microparticles.. J Am Soc Nephrol, 23(1), 49 - 62. doi:10.1681/ASN.2011030298
    • Pryce JW, Weber MA, Heales S, Krywawych S, Ashworth MT, Klein NJ, Sebire NJ (2012). Postmortem tandem mass spectrometry profiling for detection of infection in unexpected infant death.. Forensic Sci Med Pathol, 8(3), 252 - 258. doi:10.1007/s12024-011-9308-8

    2011

    • Eleftheriou D, Yong Y, Klein NJ, Brogan PA (2011). Thromboembolic disease in systemic vasculitis is associated with an enhanced microparticle-mediated thrombin generation.
    • Welzen MEB, Brüggemann RJM, Burger DM, Warris A, Van Den Berg JM, Pajkrt D, Voogt HW, Gilissen JH, Klein N (2011). Nieuw schema voor tweemaal-daagse dosering van posaconazolprofylaxe bij kinderen met chronische granulomateuze ziekte resulteert in adequate blootstelling. Pharmaceutisch Weekblad, 146(50), 211 - 214.
    • Arrigoni FI, Matarin M, Thompson PJ, Michaelides M, McClements ME, Redmond E, Clarke L, Ellins E, Mohamed S, Pavord I, Klein N, Hunt DM, Moore AT, Halcox J, Sisodiya SM (2011). Extended extraocular phenotype of PROM1 mutation in kindreds with known autosomal dominant macular dystrophy.. Eur J Hum Genet, 19(2), 131 - 137. doi:10.1038/ejhg.2010.147
    • Bishay M, Retrosi G, Horn V, Cloutman-Green E, Harris K, De Coppi P, Klein N, Eaton S, Pierro A (2011). Chlorhexidine antisepsis significantly reduces the incidence of sepsis and septicemia during parenteral nutrition in surgical infants.. J Pediatr Surg, 46(6), 1064 - 1069. doi:10.1016/j.jpedsurg.2011.03.028
    • Edwards LA, Lucas M, Edwards EA, Torrente F, Heuschkel RB, Klein NJ, Murch SH, Bajaj-Elliott M, Phillips AD (2011). Aberrant response to commensal Bacteroides thetaiotaomicron in Crohn's disease: an ex vivo human organ culture study.. Inflamm Bowel Dis, 17(5), 1201 - 1208. doi:10.1002/ibd.21501
    • Pryce JW, Roberts SE, Weber MA, Klein NJ, Ashworth MT, Sebire NJ (2011). Microbiological findings in sudden unexpected death in infancy: comparison of immediate postmortem sampling in casualty departments and at autopsy.. J Clin Pathol, 64(5), 421 - 425. doi:10.1136/jcp.2011.089698
    • Klein N (2011). WHAT IS SEPSIS AND HOW SHOULD WE MANAGE IT?. PEDIATRIC RESEARCH, 70, 26 - 26. doi:10.1038/pr.2011.251
    • Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, Yeung RS, Tan DE, Sim KS, Wang JJ, Wong TY, Pang J, Mitchell P, Cimaz R, Dahdah N, Cheung YF, Huang GY, Yang W, Park IS, Lee JK, Wu JY, Levin M, Burns JC, Burgner D, Kuijpers TW, Hibberd ML, Hong Kong–Shanghai Kawasaki Disease Genetics Consortium , Korean Kawasaki Disease Genetics Consortium , Taiwan Kawasaki Disease Genetics Consortium , International Kawasaki Disease Genetics Consortium , US Kawasaki Disease Genetics Consortium , Blue Mountains Eye Study (2011). Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.. Nat Genet, 43(12), 1241 - 1246. doi:10.1038/ng.981
    • Edwards LA, Bajaj-Elliott M, Klein NJ, Murch SH, Phillips AD (2011). Bacterial-epithelial contact is a key determinant of host innate immune responses to enteropathogenic and enteroaggregative Escherichia coli.. PLoS One, 6(10), e27030 - . doi:10.1371/journal.pone.0027030
    • Hall SM, Davie N, Klein N, Haworth SG (2011). Endothelin receptor expression in idiopathic pulmonary arterial hypertension: effect of bosentan and epoprostenol treatment.. Eur Respir J, 38(4), 851 - 860. doi:10.1183/09031936.00167010
    • Welzen ME, Brüggemann RJ, Van Den Berg JM, Voogt HW, Gilissen JH, Pajkrt D, Klein N, Burger DM, Warris A (2011). A twice daily posaconazole dosing algorithm for children with chronic granulomatous disease.. Pediatr Infect Dis J, 30(9), 794 - 797. doi:10.1097/INF.0b013e3182195808
    • Weber MA, Hartley JC, Klein NJ, Risdon RA, Malone M, Sebire NJ (2011). Staphylococcal toxins in sudden unexpected death in infancy: experience from a single specialist centre.. Forensic Sci Med Pathol, 7(2), 141 - 147. doi:10.1007/s12024-010-9199-0

    2010

    • Agius E, Lacy K, Vukmanovic-Stejic M, Papageorgiou AP, Hall S, Reed JR, Curnow J, Taams LS, Jagger A, Fuentes-Duculan J, Buckley C, Salmon M, Krueger J, Greenwood J, Klein N, Rustin M, Akbar AN (2010). Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4(+) T cells during ageing.
    • Charakida M, Donald AE, Leary S, Halcox JP, Turner MW, Johnson M, Loukogeorgakis SP, Okorie MI, Davey Smith G, Deanfield JE, Klein NJ (2010). Endothelial response to childhood infection: the role of mannose-binding lectin (MBL).. Atherosclerosis, 208(1), 217 - 221. doi:10.1016/j.atherosclerosis.2009.07.055
    • Chan E, Schaller T, Klein N, Thrasher A, Towers G, Qasim W (2010). Lentiviral Delivery of TRIM-Cyclophilin Restriction Factors Against HIV-1.
    • Weber M, Hartley JC, Brooke I, Lock PE, Klein NJ, Malone M, Sebire NJ (2010). Post-mortem interval and bacteriological culture yield in sudden unexpected death in infancy (SUDI). Forensic Science International, 1998(1-3), 121 - 125.
    • Weber MA, Hartley JC, Brooke I, Lock PE, Klein NJ, Malone M, Sebire NJ (2010). Post-mortem interval and bacteriological culture yield in sudden unexpected death in infancy (SUDI).. Forensic Sci Int, 198(1-3), 121 - 125. doi:10.1016/j.forsciint.2010.02.002
    • Williams B, Neth O, Shingadia D, Dixon G, Jupp RS, Rosendahl K, Eastwood D, Klein N, Brogan P (2010). Mycobacterium kansasii causing septic arthritis and osteomyelitis in a child. Pediatr Infect Dis J, , - . doi:10.1097/INF.0b013e3181b78e8b
    • Edwards LA, Lucas M, Edwards EA, Torrente F, Heuschkel RB, Klein NJ, Murch SH, Bajaj-Elliott M, Phillips AD (2010). Aberrant response to commensal Bacteroides thetaiotaomicron in Crohn's disease: An ex vivo human organ culture study.. Inflamm Bowel Dis, , - . doi:10.1002/ibd.21501
    • Agbeko RS, Peters MJ, Allen ML, Fidler KJ, Klein NJ, Wilson P (2010). Genetic variability in complement activation modulates the systemic inflammatory response syndrome in children. Pediatric Critical Care Medicine, 11(5), 561 - 567. doi:10.1097/PCC.0b013e3181d900ba
    • Neth OW, Bacher U, Das P, Zabelina T, Kabisch H, Kroeger N, Ayuk F, Lioznov M, Waschke O, Fehse B, Thiébaut R, Haston RM, Klein N, Zander AR (2010). Influence of mannose-binding lectin genotypes and serostatus in allo-SCT: analysis of 131 recipients and donors.. Bone Marrow Transplant, 45(1), 13 - 19. doi:10.1038/bmt.2009.90
    • Gjelstrup LC, Boesen T, Kragstrup TW, Jorgensen A, Klein NJ, Thiel S, Deleuran BW, Vorup-Jensen T (2010). Shedding of Large Functionally Active CD11/CD18 Integrin Complexes from Leukocyte Membranes during Synovial Inflammation Distinguishes Three Types of Arthritis through Differential Epitope Exposure. J IMMUNOL, 185(7), 4154 - 4168. doi:10.4049/jimmunol.1000952
    • Ackland GL, Del Arroyo AG, Yao ST, Stephens RC, Dyson A, Klein NJ, Singer M, Gourine AV (2010). Low molecular weight polyethylene glycol improves survival in experimental sepsis.. Critical Care Medicine, 38, 629 - 636.
    • Walsh TJ, Driscoll T, Milligan PA, Wood ND, Schlamm H, Groll AH, Jafri H, Arrieta AC, Klein NJ, Lutsar I (2010). Pharmacokinetics, safety, and tolerability of voriconazole in immunocompromised children.. Antimicrob Agents Chemother, 54(10), 4116 - 4123. doi:10.1128/AAC.00896-10
    • Agbeko RS, Holloway JW, Allen ML, Ye S, Fidler KJ, Pappachan J, Goldman A, Pontefract D, Deanfield J, Klein NJ, Peters MJ (2010). Genetic polymorphisms in the endotoxin receptor may influence platelet count as part of the acute phase response in critically ill children.. Intensive Care Med, 36(6), 1023 - 1032. doi:10.1007/s00134-010-1857-x
    • Gjelstrup LC, Boesen T, Kragstrup TW, Jorgensen A, Klein NJ, Thiel S, Deleuran BW, Vorup-Jensen T (2010). Functionally Active CD11/CD18 Integrin Complexes are Shedded From the Leukocyte Membranes in Chronic Inflammation Disorders.
    • Agbeko RS, Holloway JW, Allen ML, Ye S, Fidler KJ, Pappachan J, Goldman A, Pontefract D, Deanfield J, Klein NJ (2010). Genetic polymorphisms in the endotoxin receptor may influence platelet count as part of the acute phase response in critically ill children. Intensive Care Medicine, 36(6), 1023 - 1032.
    • Eleftheriou D, Cox T, Saunders D, Klein NJ, Brogan PA, Ganesan V (2010). Investigation of childhood central nervous system vasculitis: magnetic resonance angiography versus catheter cerebral angiography.. Dev Med Child Neurol, 52(9), 863 - 867. doi:10.1111/j.1469-8749.2009.03591.x
    • Dixon G, Booth C, Price E, Westran R, Turner M, Klein N (2010). Fever as nature's engine Part of beneficial host response?. BRIT MED J, 340, - . doi:10.1136/bmj.c450
    • Clarke LA, Hong Y, Eleftheriou D, Shah V, Arrigoni F, Klein NJ, Brogan PA (2010). Endothelial injury and repair in systemic vasculitis of the young.. Arthritis Rheum, 62(6), 1770 - 1780. doi:10.1002/art.27418

    2009

    • Burgner D, Davila S, Breunis WB, Ng SB, Li Y, Bonnard C, Ling L, Wright VJ, Thalamuthu A, Odam M, Shimizu C, Burns JC, Levin M, Kuijpers TW, Hibberd ML, Consortium IKDG (2009). A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease.. PLoS Genetics, 5(1), - . doi:10.1371/journal.pgen.1000319
    • Neth OW, Bacher U, Das P, Zabelina T, Kabisch H, Kroeger N, Ayuk F, Lioznov M, Waschke O, Fehse B, Thiebaut R, Haston RM, Klein N, Zander AR (2009). Influence of mannose-binding lectin genotypes and serostatus in Allo-SCT: analysis of 131 recipients and donors. Bone Marrow Transplantation, , - .
    • Alexander N, Eaton S, Haston M, Wallace AS, Smith VV, Burns AJ, Salomon J, Shah N, Klein NJ, Pierro A, Thapar N (2009). Hirschsprung's disease associated enterocolitis is related to defects in innate immunity.
    • Jones HE, Harris KA, Azizia M, Bank L, Carpenter B, Hartley JC, Klein N, Peebles D (2009). Differing prevalence and diversity of bacterial species in fetal membranes from very preterm and term labor.. PLoS One, 4(12), e8205 - . doi:10.1371/journal.pone.0008205
    • Hall S, Brogan P, Haworth SG, Klein N (2009). Contribution of inflammation to the pathology of idiopathic pulmonary arterial hypertension in children. Thorax, 64(9), 778 - 783.
    • Agius E, Lacy KE, Vukmanovic-Stejic M, Jagger AL, Papageorgiou AP, Hall S, Reed JR, Curnow SJ, Fuentes-Duculan J, Buckley CD, Salmon M, Taams LS, Krueger J, Greenwood J, Klein N, Rustin MH, Akbar AN (2009). Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging. J.Exp.Med., 206(9), 1929 - 1940. doi:10.1084/jem.20090896
    • Eleftheriou D, Melo M, Marks SD, Tullus K, Sills J, Cleary G, Dolezalova P, Ozen S, Pilkington C, Woo P, Klein N, Dillon MJ, Brogan PA (2009). Biologic therapy in primary systemic vasculitis of the young. Rheumatology, 48(8), 978 - 986.
    • Garrett-Cox RG, Stefanutti G, Booth C, Klein NJ, Pierro A, Eaton S (2009). Glutamine decreases inflammation in infant rat endotoxemia. J Pediatr Surg, 44(3), 523 - 529.
    • Jones HE, Azizia M, Harris KA, Hartley JC, Klein N, Peebles D (2009). The Role of Infection in Preterm Labour: Broad-Range 16S rDNA PCR Identifies a Variety of Bacterial Candidates.
    • El-Radhi AS, Carroll J, Klein N (2009). Clinical manual of fever in children. Clinical Manual of Fever in Children, , 1 - 318. doi:10.1007/978-3-540-78598-9
    • Fidler KJ, Hilliard TN, Bush A, Johnson M, Geddes DM, Turner MW, Alton EW, Klein NJ, Davies JC (2009). Mannose-binding lectin is present in the infected airway: a possible pulmonary defence mechanism.. Thorax, 64(2), 150 - 155. doi:10.1136/thx.2008.100073
    • Brogan RJ, Eleftheriou D, Gnanapragasam J, Klein NJ, Brogan PA (2009). Infliximab for the treatment of intravenous immunoglobulin resistant Kawasaki disease complicated by coronary artery aneurysms: a case report. Pediatric Rheumatology, 7(1), 3 - .
    • Agius E, Lacy K, Vukmanovic-Stejic M, Papageorgiou P, Hall S, Reed JR, Curnow J, Taams LS, Jagger AL, Fuentes-Duculan J, Buckley C, Salmon M, Krueger J, Greenwood J, Klein N, Rustin M, Akbar AN (2009). Tumour necrosis factor-alpha synthesis by macrophages is impaired during secondary cutaneous immune responses in old subjects. British Journal of Dermatology, 160(4), 911 - 912.
    • Eleftheriou D, Hong Y, Clarke LA, Klein NJ, Brogan PA, Ganesan V (2009). Endothelial Injury And Repair In Childhood Cerebral Arteriopathy.
    • Jones HE, Azizia M, Harris KA, Hartley JC, Klein N, Peebles D (2009). The Role of Infection in Preterm Labour: Broad-Range 16S rDNA PCR Identifies a Variety of Bacterial Candidates. Reproductive Sciences, 16(3), 465 - .
    • Allen M, Klein N, Peters M (2009). The Immune System. In Helfaer M, Nichols D (Ed.), Rogers' Handbook of Pediatric Intensive Care (pp. 433 - 440). : Lippincott Williams & Wilkins.
    • Charakida M, Loukogeorgakis SP, Okorie MI, Masi S, Halcox JP, Deanfield JE, Klein NJ (2009). Increased arterial stiffness in HIV-infected children: risk factors and antiretroviral therapy. Antiviral Therapy, 14(8), 1075 - 1079.
    • Agius E, Lacy K, Vukmanovic-Stejic M, Papageorgiou P, Hall S, Reed JR, Curnow J, Taams LS, Jagger AL, Fuentes-Duculan J, Buckley C, Salmon M, Krueger J, Greenwood J, Klein N, Rustin M, Akbar AN (2009). Tumour necrosis factor-alpha synthesis by macrophages is impaired during secondary cutaneous immune responses in old subjects.
    • Williams B, Neth O, Shingadia D, Dixon G, Jupp RS, Rosendahl K, Eastwood D, Klein N, Brogan P (2009). MYCOBACTERIUM KANSASII CAUSING SEPTIC ARTHRITIS AND. Pediatr Infect Dis J, , - .
    • Haustein T, Ridout DA, Hartley JC, Thaker U, Shingadia D, Klein NJ, Novelli V, Dixon GL (2009). The Likelihood of an Indeterminate Test Result from a Whole-Blood Interferon-gamma Release Assay for the Diagnosis of Mycobacterium tuberculosis Infection in Children Correlates With Age and Immune Status. Pediatr Infect Dis J, 28(8), 669 - 673.
    • Garrett-Cox RG, Stefanutti G, Booth C, Klein NJ, Pierro A, Eaton S (2009). Glutamine decreases inflammation in infant rat endotoxemia.. J Pediatr Surg, 44(3), 523 - 529. doi:10.1016/j.jpedsurg.2008.09.007

    2008

    • Callard RE, Bains I, Sefe D, Klein N, Yates A, Thiebaut R (2008). T cell homeostasis and HIV infection.
    • Allen M, Klein N, Peters MJ (2008). The Immune System. In Nichols DG (Ed.), Rogers Textbook of Pediatric Intensive Care (pp. 1209 - 1225). : Lippincott Williams & Wilkins.
    • Eleftheriou D, Amin T, Hook CE, Auchterlonie I, Houlsby WT, Denison A, Rosendhal K, Davidson JE, Klein N, Brogan PA (2008). Castleman's disease in childhood: a surgically curable mimic of autoimmune disease. Rheumatology (Oxford), 47(9), 1435 - 1436. doi:10.1093/rheumatology/ken285
    • Steeghs L, Keestra AM, van Mourik A, Uronen-Hansson H, van der Ley P, Callard R, Klein N, van Putten JP (2008). Differential Activation of Human and Mouse Toll-Like Receptor 4 by the Adjuvant Candidate LpxL1 of Neisseria meningitidis. Infection and Immunity, 76(8), 3801 - 3807.
    • Simmonds J, Fenton M, Dewar C, Ellins E, Storry C, Cubitt D, Deanfield J, Klein N, Halcox J, Burch M (2008). Endothelial dysfunction and cytomegalovirus replication in pediatric heart transplantation. Circulation, 117(20):2657-61(20), 2657 - 2661.
    • Agius E, Lacy K, Vukmanovic-Stejic M, Hall S, Klein N, Rustin M, Akbar AN (2008). Endothelial activation is impaired in old skin secondary cutaneous memory immune responses in vivo.
    • Agius E, Lacy K, Vukmanovic-Stejic M, Papageorgiou AP, Curnow I, Greenwood J, Klein N, Rustin M, Akbar AN (2008). Decreased endothelial activation results in defective secondary T cell immunity in aging skin.
    • Plunkett A, Agbeko R, Li K, Humphries SE, Klein NJ, Peters MJ (2008). Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children. Intensive Care Medicine, 34(12), 2279 - 2283.
    • Lozanoska-Ochser B, Alvarez RA, Peakman M, Klein NJ, Huang GC (2008). Expression of CD86 on human islet endothelial cells facilitates T cell adhesion and migration. Journal of Immunology, 181(9), 6109 - 6116.
    • Jacobsen MC, Thiebaut R, Fisher C, Sefe D, Clapson M, Klein N, Baxendale H (2008). Pediatric Human Immunodeficiency Virus Infection and Circulating IgD(+) Memory B Cells. The Journal of Infectious Diseases, 198(4), 481 - 485.
    • Baxendale H, Johnson M, Stephens RCM, Yuste J, Klein N, Brown JS, Goldblatt D (2008). Natural human antibodies to pneumococcus have distinctive molecular characteristics and protect against pneumococcal disease. Clinical and Experimental Immunology, 151(1), 51 - 60.
    • Prendergast A, Walls T, Turner P, Cubitt D, Hartley J, Klein N, Novelli V (2008). Comment on: Antimicrobial policies in the neonatal units of the United Kingdom and Republic of Ireland. Journal of Antimicrobial Chemotherapy, 62(2), 429 - 430.
    • Agius E, Lacy K, Vukmanovic-Stejic M, Papageorgiou AP, Hall S, Reed JR, Curnow J, Salmon M, Greenwood J, Klein N, Rustin MHA, Akbar AN (2008). Decreased secondary cutaneous memory immune response in old skin due to lack of endothelial activation.
    • Clarke LA, Shah V, Arrigoni F, Eleftheriou D, Hong Y, Halcox J, Klein N, Brogan PA (2008). Quantitative detection of circulating endothelial cells in vasculitis: comparison of flow cytometry and immunomagnetic bead extraction.. J Thromb Haemost, 6(6), 1025 - 1032. doi:10.1111/j.1538-7836.2008.02953.x
    • Dzwonek AB, Neth OW, Thiebaut R, Gulczynska E, Chilton M, Hellwig T, Bajaj-Elliott M, Hawdon J, Klein NJ (2008). The role of mannose-binding lectin in susceptibility to infection in preterm neonates. Pediatr Res, 63(6), 680 - 685.
    • Weber M, Klein N, Hartley J, Lock P, Malone M, Sebire N (2008). Infection and sudden unexpected death in infancy: a systematic retrospective case review. The Lancet, 371(9627), 1848 - 1853.
    • Eisen S, Dzwonek A, Klein NJ (2008). Mannose-binding lectin in HIV infection. FUTURE VIROL, 3(3), 225 - 233. doi:10.2217/17460794.3.3.225
    • Jones HE, Strid J, Osman M, Uronen-Hansson H, Dixon G, Klein N, Wong SY, Callard RE (2008). The role of beta(2) integrins and lipopolysaccharide-binding protein in the phagocytosis of dead Neisseria meningitidis. Cellular Microbiology, Epub ahead of pr, - .
    • Brogan PA, Shah V, Clarke LA, Dillon MJ, Klein N (2008). T cell activation profiles in Kawasaki syndrome. Clinical and Experimental Immunology, 151(2), 267 - 274.
    • Weber MA, Hartley J, Klein N, Malone M, Sebire NJ (2008). The role of bacteriological investigations in determining the cause of infant death.
    • Agius E, Lacy K, Vukmanovic-Stejic M, Hall S, Klein N, Rustin M, Akbar AN (2008). Endothelial activation is impaired in old skin secondary cutaneous memory immune responses in vivo. British Journal of Dermatology, 158(4), 886 - 887.
    • Burns S, Hardy S, Bouma G, Klein N, Thrasher AJ (2008). Dendritic cells require CD18 for normal podosome formation.

    2007

    • Lloyd J, Aziza M, Allen M, Klein N, Peebles D (2007). Correlation between MHC class II expression on cord blood monocytes and outcome in term and preterm neonates. BJOG-INT J OBSTET GY, 114(8), 1035 - 1035.
    • Weber MA, Hartley J, Klein N, Lock P, Risdon RA, Malone M, Sebire NJ (2007). Role of Post-Mortem Bacteriological Investigations in SUDI: 10-Year Experience from a Single Specialist Centre.
    • Burns S, Hardy S, Klein N, Thrasher A (2007). CD18 is required for normal podosome formation during adhesion and migration of human dendritic cells.
    • Stefanutti G, Pierro A, Smith VV, Klein NJ, Eaton S (2007). Peroxynitrite decomposition catalyst FeTMPyP provides partial protection against intestinal ischemia and reperfusion injury in infant rats.. Pediatr Res, 62(1), 43 - 48. doi:10.1203/PDR.0b013e31806790c0
    • Zilbauer M, Dorrell N, Elmi A, Lindley KJ, Schuller S, Jones HE, Klein NJ, Nunez G, Wren BW, Bajaj-Elliott M (2007). A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni (vol 9, pg 2404, 2007). CELL MICROBIOL, 9(10), 2541 - 2541. doi:10.1111/j.1462-5822.2007.01008.x
    • Zilbauer M, Dorrell N, Elmi A, Lindley KJ, Schuller S, Jones HE, Klein NJ, Nunez G, Wren BW, Bajaj-Elliott M (2007). A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni.. Cellular Microbiology, 9(10), 2404 - 2416. doi:10.1111/j.1462-5822.2007.00969.x
    • Yates AJ, Stark J, Klein N, Antia R, Callard RE (2007). Understanding the slow depletion of memory CD4+ T cells in HIV infection. PLoS Medicine, 4(5), 177 - . doi:10.1371/journal.pmed.0040177
    • Simmond JD, Fenton MJ, Burch M, Klein NJ, Ellins EA, Storry C, O'Meagher S, Redmond EM, Donald AE, Scott CA, Halcox JPJ (2007). Cytomegalovirus replication is associated with endothelial dysfunction in pediatric heart transplant recipients.
    • Simmonds JD, Fenton MJ, Halcox JPJ, Klein NJ, Ellins LM, Storry C, Omeagher S, Redmond LM, Donald AE, Scott CA, Burch M (2007). Cytomegalovirus replication is associated with endothelial dysfunction in pediatric heart transplant recipients. J HEART LUNG TRANSPL, 26(2), S147 - S147.
    • Agbeko R, Fidler K, Wilson P, Klein N, Peters MJ (2007). The association of mannose binding lectin deficiency and systemic inflammatory response syndrome is unaffected by other complement and cytokine single nucleotide polymorphisms.
    • Agbeko R, Holloway J, Fidler K, Pappachan J, Wilson P, Stephens R, Klein N, Peters MJ (2007). Genetic variation in endotoxin recognition and the development of the systemic inflammatory response syndrome in critically ill children.
    • Allen ML, Klein NJ, Peters MJ (2007). The Immune System. In (Ed.), Rogers Textbook of Pediatric Intensive Care (pp. - ). : .
    • Zanone MM, Favaro E, Ferioli E, Huang GC, Klein NJ, Perin PC, Peakman M, Conaldi PG, Camussi G (2007). Human pancreatic islet endothelial cells express coxsackievirus and adenovirus receptor and are activated by coxsackie B virus infection. The FASEB Journal, , - .
    • Jones HE, Uronen-Hansson H, Callard RE, Klein N, Dixon GL (2007). The differential response of human dendritic cells to live and killed Neisseria meningitidis. Cellular Microbiology, 9(12), 2856 - 2869.
    • Jones SM, Weinstein JM, Cumberland P, Klein N, Nischal KK (2007). Visual outcome and corneal changes in children with chronic blepharokeratoconjunctivitis. Ophthalmology, 114(12), 2271 - 2280.
    • Lloyd J, Allen M, Azizia M, Klein N, Peebles D (2007). Monocyte major histocompatibility complex class II expression in term and preterm labor. Obstetrics and Gynecology, 110(6), 1335 - 1342.
    • Weber MA, Hartley J, Klein N, Malone M, Sebire NJ (2007). Effect of post mortem interval on bacteriological yield in sudden unexpected death in infancy.
    • Stefanutti G, Pierro A, Smith VV, Klein NJ, Eaton S (2007). Peroxynitrite decomposition catalyst FeTMPyP provides partial protection against intestinal ischaemia and reperfusion injury in infant rats. Pediatric Research, 62(1), 43 - 48. doi:10.1203/PDR.0b013e31806790c0

    2006

    • Lloyd J, Allen ML, Klein NJ, Peebles DM (2006). Correlation between MHC class II expression on cord blood monocytes and outcome in term and preterm neonates..
    • Pharoah DS, Varsani H, Tatham RW, Newton KR, de Jager W, Prakken BJ, Klein N, Wedderburn LR (2006). Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells. Arthritis Research and Therapy, 8(2), 50 - 60.
    • Stephens RC, Fidler K, Wilson P, Barclay GR, Mythen MG, Dixon GL, Turner MW, Klein NJ, Peters MJ (2006). Endotoxin immunity and the developmentof the systemic inflammatory responsesyndrome in critically ill children. Intensive Care Medicine, 32(2), 286 - 294.
    • Allen ML, Hoschtitzky JA, Peters MJ, Elliott M, Goldman A, James I, Klein NJ (2006). Interleukin-10 and its role in clinical immunoparalysis following pediatric cardiac surgery*. Crit Care Med, , - .
    • Inwald DP, Faust SN, Lister P, Peters MJ, Levin M, Heyderman R, Klein NJ (2006). Platelet and soluble CD40L in meningococcal sepsis. INTENSIVE CARE MED, 32(9), 1432 - 1437.
    • Dommett RM, Klein N, Turner MW (2006). Mannose-binding lectin in innate immunity: past, present and future. Tissue Antigens, 68(3), 193 - 209.
    • Charakida M, Halcox JP, Sangle SR, Donald AE, Mackworth-Young C, Klein N, Hughes GRV, D'Cruz DP, Deanfield JE (2006). Preclinical atherosclerotic phenotype in patients with primary antiphospholipid syndrome..
    • Boughan PK, Argent RH, Body-Malapel M, Park JH, Ewings KE, Bowie AG, Ong SJ, Cook SJ, Sorensen OE, Manzo BA, Klein NJ, Nunez G, Atherton JC, Bajaj-Elliott M (2006). Nucleotide-binding oligomerisation domain-1 (NOD-1) and epidermal growth factor receptor (EGFR): Critical regulators of beta -defensins during helicobacter pylori infection. Journal of Biological Chemistry, 281(17), 11637 - 11648. doi:10.1074/jbc.M510275200
    • Richards PG, Bertocci GE, Bonshek RE, Giangrande PL, Gregson RM, Jaspan T, Jenny C, Klein N, Lawler W, Peters M, Rorke-Adams LB, Vyas H, Wade A (2006). Shaken baby syndrome. Archives of Disease in Childhood, 91(3), 205 - 206.
    • Tully J, Viner RM, Coen PG, Stuart JM, Zambon M, Peckham C, Booth C, Klein N, Kaczmarski E, Booy R (2006). Risk and protective factors for meningococcal disease in adolescents. BMJ (Clinical Research Ed.), 332(7539), 445 - 450. doi:10.1136/bmj.38725.728472.BE
    • Lloyd J, Allen ML, Klein NJ, Peebles DN (2006). Effect of preterm and term labour on maternal monocyte MHC class II expression..
    • Gordon AC, Waheed U, Hansen TK, Hitman GA, Garrard CS, Turner MW, Klein NJ, Brett SJ, Hinds CJ (2006). Mannose-binding lectin polymorphisms in severe sepsis: Relationship to levels, incidence, and outcome. Shock, 25(1), 88 - 93.
    • Steeghs L, van Vliet SJ, Uronen-Hansson H, van Mourik A, Engering A, Sanchez-Hernandez M, Klein N, Callard R, van Putten JP, Van Der Ley P, van Kooyk Y, van de Winkel JG (2006). Neisseria meningitidis expressing lgtB lipopolysaccharide targets DC-SIGN and modulates dendritic cell function. Cellular Microbiology, 8(2), 316 - 325.
    • Dzwonek A, Novelli V, Bajaj-Elliott M, Turner M, Clapson M, Klein N (2006). Mannose-binding lectin in susceptibility and progression of HIV-1 infection in children. Antiviral Therapy, 11(4), 499 - 505.
    • Urquhart DS, Allen J, Elrayess M, Fidler K, Klein N, Jaffe A (2006). Modifier effect of the Toll-like receptor 4 D299G polymorphism in children with cystic fibrosis. Archivum Immunologiae et Therapiae Experimentalis, 54(4), 271 - 276.
    • Jack DL, Cole J, Naylor SC, Borrow R, Kaczmarski EB, Klein NJ, Read RC (2006). Genetic polymorphism of the binding domain of surfactant protein-A2 increases susceptibility to meningococcal disease. Clinical Infectious Diseases, 43(11), 1426 - 1433.
    • Neth O, Zabelina T, Das P, Waschke O, Ayuk F, Fehse B, Kroger N, Klein N, Zander A (2006). Mannose-binding lectin in allogeneic bone marrow transplantation. Bone Marrow Transplantation, 37, S168 - S168.
    • Agbeko R, Fidler K, Klein NJ, Peters MJ (2006). Incidence and severity of systemic inflammation in intensive care and mannose-binding lectin. British Journal of Intensive Care, 16(2), 52 - 57.
    • McHoney M, Klein NJ, Eaton S, Pierro A (2006). Decreased monocyte class II MHC expression following major abdominal surgery in children is related to operative stress. Pediatric Surgery International, 22(4), 330 - 334.

    2005

    • McHoney M, Eaton S, Wade A, Klein NJ, Stefanutti G, Booth C, Kiely EM, Curry JI, Drake DP, Pierro A (2005). Inflammatory response in children after laparoscopic vs open Nissen fundoplication: randomized controlled trial.. J Pediatr Surg, 40(6), 908 - 913. doi:10.1016/j.jpedsurg.2005.03.003
    • Zanone MM, Favaro E, Doublier S, Lozanoska-Ochser B, Deregibus MC, Greening J, Huang GC, Klein N, Perin PC, Peakman M, Camussi G (2005). Expression of nephrin by human pancreatic islet endothelial cells. Diabetologia, 48(9), 1789 - 1797.
    • Chowdhury M, Eaton S, Peters MJ, Klein NJ, Goldman A, Pierro A (2005). Promotion of monocyte HLA-DR expression and attenuation of cytokine response by glutamine supplementation in septic children. P NUTR SOC, 64, 16A - 16A.
    • Charakida M, Donald AE, Green H, Storry C, Clapson M, Caslake M, Dunn DT, Halcox JP, Gibb DM, Klein NJ, Deanfield JE (2005). Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy.. Circulation, 112(1), 103 - 109. doi:10.1161/CIRCULATIONAHA.104.517144
    • Zilbauer M, Dorrell N, Boughan PK, Harris A, Wren BW, Klein NJ, Bajaj-Elliott M (2005). Intestinal innate immunity to Campylobacter jejuni results in induction of bactericidal human beta-defensins 2 and 3. Infection and Immunity, 73(11), 7281 - 7289. doi:10.1128/IAI.73.11.7281-7289.2005
    • Hamvas RMJ, Johnson M, Vlieger AM, Ling C, Sherriff A, Wade A, Klein NJ, Turner MW, Webster ADB (2005). Role for mannose binding lectin in the prevention of mycoplasma infection. Infection and Immunity, 73(8), 5238 - 5240.
    • Charakida M, Donald AE, Green H, Storry C, Clapson M, Caslake M, Dunn DT, Halcox JP, Gibb DM, Klein NJ, Deanfield JE (2005). Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy. Circulation, 112(1), 103 - 109. doi:10.1161/CIRCULATIONAHA.104.517144
    • Neth OW, Bajaj-Elliott M, Turner MW, Klein NJ (2005). Susceptibility to infection in patients with neutropenia: the role of the innate immune system. British Journal of Haematology, 129(6), 713 - 722.
    • Stefanutti G, Lister P, Smith VV, Peters MJ, Klein NJ, Pierro A, Eaton S (2005). P-selectin expression, neutrophil infiltration, and histologic injury in neonates with necrotizing enterocolitis. Journal of Pediatric Surgery, 40(6), 942 - 947.
    • Charakida M, Donald AE, Terese M, Leary S, Halcox JP, Ness A, Davey Smith G, Golding J, Friberg P, Klein NJ, Deanfield JE (2005). Endothelial dysfunction in childhood infection. Circulation, 111(13), 1660 - 1665. doi:10.1161/01.CIR.0000160365.18879.1C
    • Jack DL, Lee ME, Turner MW, Klein NJ, Read RC (2005). Mannose-binding lectin enhances phagocytosis and killing of Neisseria meningitidis by human macrophages. Journal of Leukocyte Biology, 77(3), 328 - 336.
    • Mayilyan KR, Hajela K, Dommett R, Arnold JN, Soghoyan AF, Klein NJ, Sim RB (2005). MBL serum concentration and genotype in chronic schizophrenic patients in acute phase of the disease. Immunology, 116, 95 - 95.
    • McHoney M, Eaton S, Wade A, Klein NJ, Stefanutti G, Booth C, Kiely EM, Curry JI, Drake DP, Pierro A (2005). Inflammatory response in children after laparoscopic vs open Nissen fundoplication: randomized controlled trial. Journal of Pediatric Surgery, 40(6), 908 - 914.
    • Boughan PK, Argent RH, Bowie AG, Ong SJ, Cook SJ, Sorensen O, Klein NJ, Atherton JC, Bajaj-Elliott M (2005). Modulation of gastric epithelial human beta-defensins (HBD)-2 and -3 during Helicobacter pylori infection. Helicobacter, 10(5), 494 - 494.
    • De Rossi A, Walker AS, De Forni D, Klein N, Gibb DM (2005). Relationship between changes in thymic emigrants and cell-associated HIV-1 DNA in HIV-1-infected children initiating antiretroviral therapy. Antiviral Therapy, 10(1), 63 - 71.
    • Favaro E, Bottelli A, Lozanoska-Ochser B, Ferioli E, Huang GC, Klein N, Chiaravalli A, Perin PC, Camussi G, Peakman M, Conaldi PG, Zanone MM (2005). Primary and immortalised human pancreatic islet endothelial cells: phenotypic and immunological characterisation. Diabetologia, 48(12), 2552 - 2562.
    • Klein NJ (2005). Mannose-binding lectin: do we need it?. Molecular Immunology, 42(8), 919 - 924.
    • Stefanutti G, Lister P, Smith VV, Peters MJ, Klein NJ, Pierro A, Eaton S (2005). P-selectin expression, neutrophil infiltration, and histologic injury in neonates with necrotizing enterocolitis.. J Pediatr Surg, 40(6), 942 - 947. doi:10.1016/j.jpedsurg.2005.03.027

    2004

    • Kotowicz K, Callard RE, Klein NJ, Jacobs MG (2004). Interleukin-4 increases the permeability of human endothelial cells in culture.. Clinical and Experimental Allergy, 34(3), 445 - 449.
    • Writer MJ, Marshall B, Pilkington-Miksa MA, Barker SE, Jacobsen M, Bell PC, Lester DH, Tabor AB, Hailes HC, Klein N, Hart SL (2004). Targeted Gene Delivery to Human Airway Epithelial Cells with Synthetic Vectors Incorporating Novel Targeting Peptides Selected by Phage Display. Journal of Drug Targeting, 12(4), 185 - 193.
    • Fidler KJ, Wilson P, Davies JC, Turner MW, Peters MJ, Klein NJ (2004). Increased incidence and severity of the systemic inflammatory response syndrome in patients deficient in mannose-binding lectin. INTENSIVE CARE MED, 30(7), 1438 - 1445.
    • Jack DL, Lee ME, Turner MW, Klein NJ, Read RC (2004). Mannose-binding lectin enhances phagocytosis and killing of Neisseria meningitidis by human macrophages.
    • Bode L, Rudloff S, Kunz C, Strobel S, Klein N (2004). Human milk oligosaccharides reduce platelet-neutrophil complex formation and suppress neutrophil beta 2 integrin expression.
    • Brogan PA, Shah V, Brachet C, Harnden A, Mant D, Klein N, Dillon MJ (2004). Endothelial and platelet microparticles in vasculitis of the young. Arthritis and Rheumatism, 50(3), 927 - 936. doi:10.1002/art.20199
    • Uronen-Hansson H, Allen J, Osman M, Squires G, Klein N, Callard RE (2004). Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response. Immunology, 111(2), 173 - 178.
    • Brogan PA, Shah V, Klein N, Dillon MJ (2004). Vbeta-restricted T cell adherence to endothelial cells: a mechanism for superantigen-dependent vascular injury. Arthritis and Rheumatism, 50(2), 589 - 597. doi:10.1002/art.20021
    • Uronen-Hansson H, Allen J, Osman M, Squires G, Klein N, Callard RE (2004). Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria. IMMUNOLOGY, 111(2), 173 - 178. doi:10.1111/j.1365-2567.2003.01803.x
    • Uronen-Hansson H, Steeghs L, Allen J, Dixon GLJ, Osman M, Van Der Ley P, Wong SYC, Callard R, Klein N (2004). Human dendritic cell activation by Neisseria meningitidis: phagocytosis depends on expression of lipooligosaccharide (LOS) by the bacteria and is required for optimal cytokine production. Cellular Microbiology, 6(7), 625 - 637.
    • Sprong T, Jack DL, Klein NJ, Turner MW, Van Der Ley P, Steeghs L, Jacobs L, van der Meer JW, Van Deuren M (2004). Mannose binding lectin enhances IL-1beta and IL-10 induction by non-lipopolysaccharide (LPS) components of Neisseria meningitidis. Cytokine, 28(2), 59 - 66.
    • Neth O, Klein N (2004). Febrile neutropenia: past, present and future. Advances in Experimental Medicine and Biology, 549, 119 - 124.
    • Lichtarowicz-Krynska EJ, Cole TJ, Camacho-H bner C, Britto J, Levin M, Klein N, Aynsley-Green A (2004). Circulating aldosterone levels are unexpectedly low in children with acute meningococcal disease. Journal of Clinical Endocrinology and Metabolism, 89(3), 1410 - 1414.
    • Klein NJ, Kilpatrick DC (2004). Is there a role for mannan/mannose-binding lectin (MBL) in defence against infection following chemotherapy for cancer?. Clinical and Experimental Immunology, 138(2), 202 - 204.
    • Estabrook MM, Jack DL, Klein NJ, Jarvis GA (2004). Mannose-binding lectin binds to two major outer membrane proteins, opacity protein and porin, of Neisseria meningitidis. The Journal of Immunology, 172(6), 3784 - 3792.
    • Dixon GL, Heyderman RS, Van Der Ley P, Klein NJ (2004). High-level endothelial E-selectin (CD62E) cell adhesion molecule expression by a lipopolysaccharide-deficient strain of Neisseria meningitidis despite poor activation of NF-kappaB transcription factor. Clinical and Experimental Immunology, 135(1), 85 - 93.
    • Davies JC, Turner MW, Klein N (2004). Impaired pulmonary status in cystic fibrosis adults with two mutated MBL-2 alleles. European Respiratory Journal, 24(5), 798 - 804.
    • Bode L, Rudloff S, Kunz C, Strobel S, Klein N (2004). Human milk oligosaccharides reduce platelet-neutrophil complex formation leading to a decrease in neutrophil beta 2 integrin expression. Journal of Leukocyte Biology, 76(4), 820 - 826.
    • Bethell D, Hall G, Goodman TR, Klein N, Pollard AJ (2004). Resolution of orbitocerebral aspergillosis during combination treatment with voriconazole and amphotericin plus adjunctive cytokine therapy. Journal of Pediatric Hematology/Oncology, 26(5), 304 - 307.
    • Jack DL, Lee ME, Turner MW, Klein NJ, Read RC (2004). Mannose-binding lectin enhances phagocytosis and killing of Neisseria meningitidis by human macrophages. Molecular Immunology, 41(2-3), 103 - .

    2003

    • Church AJ, Dale RC, Cardoso F, Candler PM, Chapman MD, Allen ML, Klein NJ, Lees AJ, Giovannoni G (2003). CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome?. Journal of Neuroimmunology, 136(1-2), 149 - 153.
    • Peters MJ, Heyderman RS, Faust S, Dixon GL, Inwald DP, Klein NJ (2003). 1. Severe meningococcal disease is characterized by early neutrophil but not platelet activation and increased formation and consumption of platelet-neutrophil complexes.. Journal of Leukocyte Biology, 73(6), 722 - 730.
    • Urquhart DS, Allen J, Elrayess M, Fidler K, Klein N, Jaffe A (2003). Toll-like receptor 4 (TLR4) D299G polymorphism: No modifier effect in children with cystic fibrosis.
    • Weatherstone KB, Franck LS, Klein NJ (2003). Are there opportunities to decrease nosocomial infection by choice of analgesic regimen? Evidence for immunity and pain interactions. Archives of Pediatrics and Adolescent Medicine, 157(11), 1108 - 1114. doi:10.1001/archpedi.157.11.1108
    • Inwald DP, McDowall A, Peters MJ, Callard RE, Klein NJ (2003). CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation. Circulation Research, 92(9), 1041 - 1048. doi:10.1161/01.RES.0000070111.98158.6C
    • Schappi MG, Klein NJ, Lindley KJ, Rampling D, Smith VV, Goldblatt D, Milla PJ (2003). The nature of colitis in chronic granulomatous disease. Journal of Pediatric Gastroenterology and Nutrition, 36(5), 623 - 631. doi:10.1097/00005176-200305000-00006
    • Turner MW, Johnson M, Booth C, Klein N, Rolland J, Davies J (2003). Assays for human mannose-binding lectin. J IMMUNOL METHODS, 276(1-2), 147 - 149. doi:10.1016/S0022-1759(03)00107-8
    • van Saene HK, Taylor N, Donnell SC, Glynn J, Magnall VL, Okada Y, Klein NJ, Pierro A, Lloyd DA (2003). Gut overgrowth with abnormal flora: the missing link in parenteral nutrition-related sepsis in surgical neonates. European Journal of Clinical Nutrition, 57(4), 548 - 553.
    • Brogan PA, Shah V, Bagga A, Klein N, Dillon MJ (2003). T cell Vbeta repertoires in childhood vasculitides. Clinical and Experimental Immunology, 131(3), 517 - 527. doi:10.1046/j.1365-2249.2003.02081.x
    • Cruccetti A, Pierro A, Uronen H, Klein N (2003). Surgical infants on total parenteral nutrition have impaired cytokine responses to microbial challenge. Journal of Pediatric Surgery, 38(1), 138 - 142.
    • Greening JE, Tree TI, Kotowicz KT, van Halteren AG, Roep BO, Klein NJ, Peakman M (2003). Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells. Diabetes, 52(3), 717 - 725.
    • McDowall A, Inwald D, Leitinger B, Jones A, Liesner R, Klein N, Hogg N (2003). A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins. Journal of Clinical Investigation, 111(1), 51 - 60. doi:10.1172/JCI200314076
    • Peters MJ, Pierce CM, Klein NJ (2003). Mechanisms of pulmonary hypertension in Bordetella pertussis. Archives of Disease in Childhood, 88(1), 92 - 93.
    • Peters MJ, Heyderman RS, Faust S, Dixon GL, Inwald DP, Klein NJ (2003). Severe meningococcal disease is characterized by early neutrophil but not platelet activation and increased formation and consumption of platelet-neutrophil complexes. Journal of Leukocyte Biology, 73(6), 722 - 730. doi:10.1189/jlb.1002509
    • Turner MW, Johnson M, Booth C, Klein N, Rolland J, Davies J (2003). Assays for human mannose-binding lectin. Journal of Immunological Methods, 276(1-2), 147 - 149.
    • Uronen-Hansson H, Allen ML, Lichtarowicz-Krynska E, Aynsley-Green A, Cole TJ, Hoiden-Guthenberg I, Fryklund L, Klein N (2003). Growth hormone enhances proinflammatory cytokine production by monocytes in whole blood. Growth Hormone and IGF Research, 13(5), 282 - 286.
    • Zanone MM, Favaro E, Conaldi PG, Greening J, Bottelli A, Perin PC, Klein NJ, Peakman M, Camussi G (2003). Persistent infection of human microvascular endothelial cells by coxsackie B viruses induces increased expression of adhesion molecules. The Journal of Immunology, 171(1), 438 - 446.
    • Peters MJ, Pierce CM, Klein NJ, Pons M, Casano P (2003). Mechanisms of pulmonary hypertension in Bordetella pertussis [12] (multiple letters). Archives of Disease in Childhood, 88(1), 92 - 93. doi:10.1136/adc.88.1.92

    2002

    • Sampson B, Fagerhol MK, Sunderkötter C, Roth J, Golden BE, Richmond P, Klein N, Kovar IZ, Beattie JH, Wolska-Kusnierz B, Saito Y (2002). Hyperzincaemia and hypercalprotectinaemia: A new disorder of zinc metabolism. Lancet, 360(9347), 1742 - 1745. doi:10.1016/S0140-6736(02)11683-7
    • (2002). Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus. The Journal of Immunology, 169(8), 4430 - 4436.
    • Davies JC, Johnson M, Booth C, Fidler K, Bush A, Geddes DM, Alton EWFW, Turner MW, Klein N (2002). Age-specific effect of the cystic fibrosis modifier gene, MBL-2.
    • (2002). Prevention of inflammation-induced endothelial dysfunction - A novel vasculo-protective action of aspirin. Circulation, 105(22), 2600 - 2604. doi:10.1161/01.CIR.0000017863.52347.6C
    • Allen ML, Peters MJ, Goldman A, Elliott M, James I, Callard R, Klein NJ (2002). Early postoperative monocyte deactivation predicts systemic inflammation and prolonged stay in pediatric cardiac intensive care. Crit Care Med, 30, 1140 - 1145.
    • Brogan PA, Bose A, Burgner D, Shingadia D, Tulloh R, Michie C, Klein N, Booy R, Levin M, Dillon MJ (2002). Kawasaki disease: an evidence based approach to diagnosis, treatment, and proposals for future research.. Arch Dis Child, 86(4), 286 - 290. doi:10.1136/adc.86.4.286
    • (2002). The link between rotavirus vaccination and intussusception: implications for vaccine strategies. Gut, 50(1), 11 - 12.
    • Cunningham S, Meng QH, Klein N, McAnulty RJ, Hart SL (2002). Evaluation of a porcine model for pulmonary gene transfer using a novel synthetic vector. The Journal of Gene Medicine, 4(4), 438 - 446.
    • (2002). Unique case of Helicobacter sp. osteomyelitis in an immunocompetent child diagnosed by broad-range 16S PCR. Journal of Clinical Microbiology, 40(8), 3100 - 3103.
    • (2002). Mannose-Binding Lectin Accelerates Complement Activation and Increases Serum Killing of Neisseria Meningitidis Serogroup C. The Journal of Infectious Diseases, 184, 836 - 845.

    2001

    • Dale RC, Church AJ, Cardoso F, Goddard E, Cox TC, Chong WK, Williams A, Klein NJ, Neville BG, Thompson EJ, Giovannoni G (2001). Poststreptococcal acute disseminated encephalomyelitis with basal ganglia involvement and auto-reactive antibasal ganglia antibodies. Annals of Neurology, 50(5), 588 - 595. doi:10.1002/ana.1250
    • Wong CHL, Kharbanda R, Klein N, MacAlister L, Peters MJ (2001). Pro-inflammation effect of IIb-IIIa inhibition via platelet-induced neutrophil activation.
    • (2001). Characterisation of four CD18 mutants in leucocyte adhesion deficient (LAD) patients with differential capacities to support expression and function of the CD11/CD18 integrins LFA-1, Mac-1 and p150,95. Clinical and Experimental Immunology, 126, 311 - 318.
    • (2001). Contributions of Neisseria meningitidis LPS and non-LPS to proinflammatory cytokine response. Journal of Leukocyte Biology, 70, 283 - 288.
    • (2001). Dendritic cell activation and cytokine production induced by group B Neisseria meningitis: IL-12 production requires lipopolysaccharide to be expressed in intact bacteria. Infection and Immunity, 69, 4351 - 4357.
    • Jack DL, Klein NJ, Turner MW (2001). Mannose-binding lectin: targeting the microbial world for complement attack and opsonophagocytosis. Immunological Reviews, 180, 86 - 99.
    • Estabrook MM, Jack DL, Klein NJ, Jarvis GA (2001). Mannose-binding lectin (MBL) binds to two major outer membrane proteins, opacity protein and porin, of Neisseria meningitidis but not to lipooligosaccharide (LOS). CLIN INFECT DIS, 33(7), 1189 - 1189.
    • Neth O, Hann I, Turner MW, Klein NJ (2001). Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective study. The Lancet, 358(9282), 614 - 618. doi:10.1016/S0140-6736(01)05776-2
    • Dixon GL, Newton PJ, Chain BM, Katz D, Andersen SR, Wong S, van der Ley P, Klein N, Callard RE (2001). Dendritic cell activation and cytokine production induced by group B Neisseria meningitidis: interleukin-12 production depends on lipopolysaccharide expression in intact bacteria. Infection and Immunity, 69(7), 4351 - 4357. doi:10.1128/IAI.69.7.4351-4357.2001
    • Peters MJ, Ross-Russell RI, White D, Kerr SJ, Eaton FE, Keengwe IN, Tasker RC, Wade AM, Klein NJ (2001). Early severe neutropenia and thrombocytopenia identifies the highest risk cases of severe meningococcal disease. Pediatr.Crit Care Med., 2(3), 225 - 231.
    • Kharbanda RK, Peters M, Walton B, Kattenhorn M, Mullen M, Klein N, Vallance P, Deanfield J, MacAllister R (2001). Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 103(12), 1624 - 1630.
    • (2001). The link between rotavirus vaccination and intussusception: implications for vaccine strategies. Gut, 50(1), 11 - 12.
    • Heyderman RS, Peters MJ, Ison CA, Inwald DP, Faust SN, Levin M, Klein N (2001). Mechanisms of platelet-neutrophil complex formation in fulminant meningococcal disease.
    • Inwald D, Davies EG, Klein N (2001). Demystified...adhesion molecule deficiencies. Mol.Pathol., 54(1), 1 - 7.
    • (2001). Mannose-Binding Lectin Regulates the Inflammaory REsponse of Human Professional Phagocytes to Neisseria meningitidis Serogroup B. The Journal of Infectious Diseases, 184, 1152 - 1162.
    • (2001). Differential recognition of obligate anarobic bacteria by human mannose-binding lectin. Clinical and Experimental Immunology, 124, 223 - 228.
    • Inwald DP, Peters MJ, Banfield RE, Callard R, Klein N (2001). Human platelets express functional CD40: a novel mechanism for platelet activation.

    2000

    • Mok Q, Papp E, Inwald D, Peters MJ, Klein NJ (2000). Does haemofiltration clear the right cytokines?. Pediatric Critical Care Medicine, 1, 99 - .
    • Pierce C, Klein N, Peters M (2000). Is leukocytosis a predictor of mortality in severe pertussis infection?. Intensive Care Medicine, 26(10), 1512 - 1514.
    • Davies J, Alton E, Neth O, Klein N, Turner M (2000). Differential binding of mannose-binding lectin to respiratory pathogens in cystic fibrosis. Lancet, 355(9218), 1885 - 1886.
    • Inwald DP, Peters MJ, Lane R, Klein NJ, Kirkham FJ, Wade A, Evans JP (2000). Expression of interleukin 3 and granulocyte-macrophage colony-stimulating factor receptor common chain βc, β in normal haematopoiesis: Lineage specificity and proliferation-independent induction. British Journal of Haematology, 111(2), 441 - 451. doi:10.1046/j.1365-2141.2000.02348.x
    • Cale CM, Klein NJ, Winyard PJ, Woolf AS (2000). Inflammatory mediators in human renal dysplasia. Nephrology Dialysis Transplantation, 15(2), 173 - 183.
    • Ghiadoni L, Donald AE, Cropley M, Mullen MJ, Oakley G, Taylor M, O'Connor G, Betteridge J, Klein NJ, Steptoe A, Deanfield JE (2000). Mental stress induces transient endothelial dysfunction in humans. Circulation, 102(20), 2473 - 2478.
    • Inward DP, Peters MJ, Walshe D, Jones A, Davies EG, Klein NJ (2000). Absence of platelet CD40L identifies patients with X-linked hyper IgM syndrome. Clin.Exp.Immunol., 120, 499 - 502.
    • (2000). Immunomodulatory effects of breast milk oligosaccharides. Advances in Experimental Medicine and Biology, 478, 251 - 259.
    • Okada Y, Klein NJ, van Saene HKF, Webb G, Holzel H, Pierro A (2000). Bactericidal activity against coagulase-negative staphylococci is impaired in infants receiving long-term parenteral nutrition. Annals of Surgery, 231(2), 276 - 281.
    • (2000). The lipopolysaccharide structures of Salmonella typhimurium and Neisseria gonorrhoeae determine the attachment of human mannose-binding lectin to the intact organisms. Infection and Immunity, 68(1), 61 - 68.
    • Devyatyarova-Johnson M, Rees IH, Robertson BD, Turner MW, Klein NJ, Jack DL (2000). The lipopolysaccharide structures of Salmonella enterica serovar Typhimurium and Neisseria gonorrhoeae determine the attachment of human mannose-binding lectin to intact organisms.. Infect Immun, 68(7), 3894 - 3899.
    • Kotowicz K, Dixon GLJ, Klein NJ, Peters MJ, Callard RE (2000). Biological function of CD40 on human endothelial cells: costimulation with CD40 ligand and interleukin-4 selectively induces expression of vascular cell adhesion molecule-1 and P- selectin resulting in preferential adhesion of lymphocytes. Immunology, 100(4), 441 - 448.
    • Neth O, Jack DL, Dodds AW, Holzel H, Klein NJ, Turner MW (2000). Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infection and Immunity, 68(2), 688 - 693.
    • Kelly P, Jack DL, Naeem A, Mandanda B, Pollok RCG, Klein NJ, Turner MW, Farthing MJG (2000). Mannose-binding lectin is a component of innate mucosal defense against Cryptosporidium parvum in AIDS. Gastroenterology, 119(5), 1236 - 1242.
    • Uronen H, Williams AJ, Dixon G, Andersen SR, Van Der Ley P, Van Deuren M, Callard RE, Klein N (2000). Gram-negative bacteria induce proinflammatory cytokine production by monocytes in the absence of lipopolysaccharide (LPS). Clinical and Experimental Immunology, 122(3), 312 - 315.
    • Kharbanda RK, Walton BI, Peters MJ, Kattenhorn M, Mullen MJ, Klein NJ, Vallance PJ, Deanfield JE, Macallister RJ (2000). Ischemic preconditioning prevents endothelial injury and immune cell activation during ischemia-reperfusion in humans in vivo.. CIRCULATION, 102(18), 119 - 119.
    • Davies J, Neth O, Alton E, Klein N, Turner MW (2000). Differential binding of mannose-binding lectin to cystic fibrosis respiratory pathogens. The Lancet, 355, 1885 - 1886.
    • Gibb DM, Newberry A, Klein N, De Rossi A, Grosch-Woerner I, Babiker A (2000). Immune repopulation after HAART in previously untreated HIV-1- infected children. The Lancet, 355(9212), 1331 - 1332.
    • (2000). Emergency Management of meningitis. Social Medicine, 93, 225 - 229.
    • Inwald DP, Kirkham FJ, Peters MJ, Lane R, Wade A, Evans JP, Klein NJ (2000). Platelet and leucocyte activation in childhood sickle cell disease: association with nocturnal hypoxaemia. British Journal of Haematology, 111(2), 474 - 481.
    • (2000). Oligosaccharides in human milk: structural, functional and metabolic aspects. Annual Review of Nutrition, 20, 699 - 722.

    1999

    • Okada Y, Klein NJ, Pierro A (1999). Peter Paul Rickham Prize--1998. Neutrophil dysfunction the cellular mechanism of impaired immunity during total parenteral nutrition in infancy. Journal of Pediatric Surgery, 34(2), 242 - 245.
    • Murch SH, Fertleman CR, Rodrigues C, Morgan G, Klein NJ, Meadows N, Savidge TC, Phillips AD, Walker-Smith JA (1999). Autoimmune enteropathy with distinct mucosal features in T-cell activation deficiency: the contribution of T cells to the mucosal lesion. Journal of Pediatric Gastroenterology and Nutrition, 28(4), 393 - 399.
    • Dixon GLJ, Heyderman RS, Kotovicz K, Jack DL, Andersen SR, Vogel U, Frosch M, Klein N (1999). Endothelial adhesion molecule expression and its inhibition by recombinant bactericidal/permeability-increasing protein are influenced by the capsulation and lipooligosaccharide structure of Neisseria meningitidis. Infection and Immunity, 67(11), 5626 - 5633.
    • Dobbie MS, Hurst RD, Klein NJ, Surtees RAH (1999). Upregulation of intercellular adhesion molecule-1 expression on human endothelial cells by tumour necrosis factor - … in an in vitro model of the blood-brain barrier. Brain Research, 830, 330 - 336.
    • Heyderman RS, Ison CA, Peakman M, Levin M, Klein NJ (1999). Neutrophil response to Neisseria meningitidis: Inhibition of adhesion molecule expression and phagocytosis by recombinant bactericidal permeability-increasing protein (rBPI(21)). The Journal of Infectious Diseases, 179, 1288 - 1292.
    • Hogg N, Stewart MP, Scarth SL, Newton R, Shaw JM, Law SKA, Klein N (1999). A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta 2 integrins Mac-1 and LFA-1. Journal of Clinical Investigation, 103, 97 - 106.
    • Klein N, Jack D (1999). Immunodeficiency and the gut: clues to the role of the immune system in gastrointestinal disease. Italian Journal of Gastroenterology and Hepatology, 31(8), 802 - 806.
    • Peters M, Petros A, Dixon G, Inwald D, Klein NJ (1999). Acquired immunoparalysis in paediatric intensive care: prospective observational study. BMJ (Clinical Research Ed.), 400, 609 - 610.
    • Peters MJ, Kotowicz K, Klein NJ (1999). The vascular endothelium in sepsis. Current Medical Literature: infectious diseases, 13(1), 1 - 9.
    • Okada Y, Klein NJ, Pierro A (1999). Neutrophil dysfunction: The cellular mechanism of impaired immunity during total parenteral nutrition in infancy.
    • Peters MJ, Dixon G, Kotowicz KT, Hatch DJ, Heyderman RS, Klein NJ (1999). Circulating platelet-neutrophil complexes represent a subpopulation of activated neutrophils primed for adhesion, phagocytosis and intracellular killing.. Br J Haematol, 106(2), 391 - 399.
    • Klein N, Jack D (1999). Immunodeficiency and the gut: Clues to the role of the immune system in gastrointestinal disease. Italian Journal of Gastroenterology and Hepatology, 31(8), 794 - 801.
    • Peters MJ, Dixon G, Kotowicz KT, Hatch DJ, Heyderman RS, Klein NJ (1999). Circulating platelet-neutrophil complexes represent a subpopulation of activated neutrophils primed for adhesion, phagocytosis and intracellular killing. British Journal of Haematology, 106, 391 - 399.
    • Okada Y, Papp E, Klein NJ, Pierro A (1999). Total parenteral nutrition directly impairs cytokine production after bacterial challenge. Journal of Pediatric Surgery, 34(2), 277 - 280.
    • Cale CM, Klein NJ, Woolf AS (1999). Inflammatory cytokines and adhesion molecules in human renal dysplasia. Kidney International, 55, 2579 - .
    • Basu R, Muller DPR, Papp E, Merryweather I, Eaton S, Klein N, Pierro A (1999). Free radical formation in infants: The effect of critical illness, parenteral nutrition, and enteral feeding. Journal of Pediatric Surgery, 34, 1091 - 1095.
    • Kozarek RA, Klein N (1999). Basic research in endoscopy. Italian Journal of Gastroenterology and Hepatology, 31(8), 743 - 748.

    1998

    • Okada Y, Klein N, van Saene HK, Pierro A (1998). Small volumes of enteral feedings normalise immune function in infants receiving parenteral nutrition.. J Pediatr Surg, 33(1), 16 - 19.
    • Kotecha S, Silverman M, Shaw RJ, Klein N (1998). Soluble L-selectin concentration in bronchoalveolar lavage fluid obtained from infants who develop chronic lung disease of prematurity. Archives of Disease in Childhood: Fetal and Neonatal Edition, 78(2), - .
    • Peters M, Heyderman RS, Klein NJ, Shahab N, Evans ML (1998). Platelet satellitism [5] (multiple letters). New England Journal of Medicine, 339(2), 131 - 132. doi:10.1056/NEJM199807093390218
    • Peters M, Heyderman RS, Klein NJ (1998). Platelet satellitism. N.Engl.J.Med., 339(2), 131 - 132.
    • Klein N, Sen A, Rusby J, Ratip S, Modell B, Olivieri NF (1998). The psychosocial burden of Cooley's anaemia in affected children and their parents. Annals of the New York Academy of Sciences, 850, 512 - 513.
    • Cale CM, Klein NJ, Morgan G, Woolf AS (1998). Tumor necrosis factor-alpha inhibits epithelial differentiation and morphogenesis in the mouse metanephric kidney in vitro.. Int J Dev Biol, 42(5), 663 - 674.
    • Morrison JJ, Klein N, Chitty LS, Kocjan G, Walshe D, Goulding M, Geary MP, Pierro A, Rodeck CH (1998). Intra-amniotic inflammation in human gastroschisis: possible aetiology of postnatal bowel dysfunction. Br.J.Obstet.Gynaecol., 105(11), 1200 - 1204.
    • Jack DL, Dodds AW, Anwar N, Ison CA, Law A, Frosch M, Turner MW, Klein NJ (1998). Activation of complement by mannose-binding lectin on isogenic mutants of Neisseria meningitidis serogroup B.. J Immunol, 160(3), 1346 - 1353.

    1997

    • Gibb DM, Masters J, Shingadia D, Trickett S, Klein N, Duggan C, Novelli V, Mercey D (1997). A family clinic-optimising care for HIV infected children and their families. Archives of Disease in Childhood, 77, 478 - 482.
    • Cale CM, Klein NJ, Novelli V, Veys P, Jones AM, Morgan G (1997). Severe combined immunodeficiency with abnormalities in expression of the common leucocyte antigen, CD45. Archives of Disease in Childhood, 76, 163 - 164.
    • Gibb DM, Masters J, Shingadia D, Trickett S, Klein N, Duggan C, Novelli V, Mercey D (1997). A family clinic - optimising care for HIV infected children and their families. ARCH DIS CHILD, 77(6), 478 - 482.
    • Morrison J, Klein N, Kocjan G, Geary M, Chitty LS, Rodeck CH (1997). Flow cytometry and cytology of human amniotic fluid in fetal gastroshisis: increased CD15, CD11B and polymorph infiltration may alter outcome.
    • Peters MJ, Heyderman RS, Hatch DJ, Klein NJ (1997). Investigation of platelet-neutrophil interactions in whole blood by flow cytometry. J.Immunol.Methods, 209(2), 125 - 135.
    • Morrison J, Chitty LS, Klein N, Kockjan J, Geary M, Rodeck CH (1997). Flow cytometry and cytology of human anmiotic fluid in fetal gastroschisis: increased CD15, CD11B and polymorph infiltration may alter outcome.
    • Heyderman RS, Daramola OA, Levin M, Robertson BD, Ison CA, Klein NJ, Hammerschmidt S, Frosch M (1997). Induction of human endothelial tissue factor expression by Neisseria meningitidis: The influence of bacterial killing and adherence to the endothelium. Microbial Pathogenesis, 22(5), 265 - 274. doi:10.1006/mpat.1996.0112
    • Daramola OA, Heyderman RS, Shennan GI, Levin M, Klein NJ (1997). Detection of fibronectin expression by human endothelial cells using an enzyme-linked immunosorbent assay (ELISA): Enzymatic degradation by activated plasminogen. Journal of Immunological Methods, 202(1), 67 - 75. doi:10.1016/S0022-1759(96)00237-2

    1996

    • Dos Santos WLC, Rahman J, Male DK, Klein N (1996). Control of lymphocyte adhesion to brain and aortic endothelium: ICAM-1, VCAM-1 and negative charge. Journal of Neuroimmunology, 66(1-2), 125 - 134. doi:10.1016/0165-5728(96)00037-9
    • Murch SH, Costeloe K, MacDonald TT, Klein NJ (1996). Early production of macrophage inflammatory protein-1α occurs in respiratory distress syndrome and is associated with poor outcome. Pediatric Research, 40(3), 490 - 497.
    • Murch SH, Costeloe K, MacDonald TT, Rees H, Klein NJ, McIntosh N, Keeling JW (1996). Mucosal tumor necrosis factor-α production and extensive disruption of sulfated glycosaminoglycans begin within hours of birth in neonatal respiratory distress syndrome. Pediatric Research, 40(3), 484 - 489.
    • Kotowicz K, Callard RE, Friedrich K, Matthews DJ, Klein N (1996). Biological activity of IL-4 and IL-13 on human endothelial cells: functional evidence that both cytokines act through the same receptor.. Int Immunol, 8(12), 1915 - 1925.
    • Ade-Ajayi N, Spitz L, Kiely E, Drake D, Klein N (1996). Intestinal glycosaminoglycans in neonatal necrotizing enterocolitis. British Journal of Surgery, 83(3), 415 - 418. doi:10.1002/bjs.1800830339
    • Klein NJ, Ison CA, Peakman M, Levin M, Hammerschmidt S, Frosch M, Heyderman RS (1996). The influence of capsulation and lipooligosaccharide structure on neutrophil adhesion molecule expression and endothelial injury by Neisseria meningitidis.. J Infect Dis, 173(1), 172 - 179.
    • Murch SH, Winyard PJ, Koletzko S, Wehner B, Cheema HA, Risdon RA, Phillips AD, Meadows N, Klein NJ, Walker-Smith JA (1996). Congenital enterocyte heparan sulphate deficiency with massive albumin loss, secretory diarrhoea, and malnutrition. The Lancet, 347(9011), 1299 - 1301.

    1995

    • Ison CA, Heyderman RS, Levin M, Klein NJ, Peakman M (1995). Whole blood model of meningococcal bacteraemia - A method for exploring host-bacterial interactions. Microbial Pathogenesis, 18(2), 97 - 107. doi:10.1016/S0882-4010(95)90093-4
    • LEVIN M, NEWPORT MJ, DSOUZA S, KALABALIKIS P, BROWN IN, LENICKER HM, AGIUS PV, DAVIES EG, THRASHER A, KLEIN N, BLACKWELL JM (1995). FAMILIAL DISSEMINATED ATYPICAL MYCOBACTERIAL INFECTION IN CHILDHOOD - A HUMAN MYCOBACTERIAL SUSCEPTIBILITY GENE. LANCET, 345(8942), 79 - 83.
    • SHINGADIA D, HOWARD MR, BRINK NS, GIBB D, KLEIN N, TEDDER R, NOVELLI V (1995). KAPOSIS-SARCOMA AND KSHV. LANCET, 346(8986), 1359 - 1360.

    1993

    • Klein NJ, Rigley KP, Callard RE (1993). IL-4 regulates the morphology, cytoskeleton, and proliferation of human umbilical vein endothelial cells: relationship between vimentin and CD23.. Int Immunol, 5(3), 293 - 301.
    • Finn A, Naik S, Klein N, Levinsky RJ, Strobel S, Elliott M (1993). Interleukin-8 release and neutrophil degranulation after pediatric cardiopulmonary bypass. J Thorac Cardiovasc Surg, 105, 234 - 241.
    • Finn A, Moat N, Rebuck N, Klein N, Strobel S, Elliott M (1993). Changes in neutrophil CD11b/CD18 and L-selectin expression and release of interleukin 8 and elastase in paediatric cardiopulmonary bypass. Agents Actions, 38 Spec No, C44 - C46.

    1991

    • KIRKHAM F, KLEIN N, HEYDERMAN R (1991). PEDIATRIC CENTRAL-NERVOUS-SYSTEM INFECTIONS. CURRENT OPINION IN NEUROLOGY AND NEUROSURGERY, 4(3), 417 - 422.

    • picat M, lewis J, musiime V, prendergast A, nathoo K, kekitiinwa A, Nahirya Ntege P, Gibb DM, Thiebaut R, Walker AS, Klein N, Callard R (). Predicting patterns of long-term CD4 reconstitution in HIV-infected children starting antiretroviral therapy. PLoS Medicine, , - .
    • Agbeko RS, Holloway J, Fidler KJ, Allen M, Goldman AP, Pappachan J, Wilson P, Stephens R, Klein NJ, Peters MJ (). Alterations In Endotoxin Recognition Influence Platelet Count But Not Systemic Inflammatory Response Syndrome.. Intensive Care Medicine, , - .
    • Bunupuradah T, Duong T, Compagnucci A, McMaster P, Bernardi S, Kanjanavanit S, Rampon O, Faye A, Saïdi Y, Riault Y, De Rossi A, Klein N, Ananworanich J, Gibb D (). Outcomes after reinitiating antiretroviral therapy in children randomized to planned treatment interruptions. AIDS, 27(4), 579 - 589. doi:10.1097/QAD.0b013e32835c1181
    • Agbeko RS, Holloway J, Fidler KJ, Allen MA, Pappachan J, Wilson P, Klein NJ, Peters MJ (). Genetic Variability In Complement Activation Modulates The Systemic Inflammatory Response Syndrome In Children. Pediatric Critical Care Medicine, , - .