Prof Steve Humphries

Photo

Personal Profile

Name: Steve Humphries Email: steve.humphries@ucl.ac.uk
Title: Prof Tel: 020 7 679 6962
Department: Centre for Cardiovascular Genetics Fax: 020 7679 6212
Position: Professor of Cardiovascular Genetics Address: BHF Laboratories, The Rayne Building, 5 University Street, London, WC1E 6JJ
Research Domain: Cardiometabolic Science, Personalised Medicine Web Page: Personal Web Page

Profile

Research Description

A large part of your research activities focus on a monogenic paradigm of early heart disease called Familial hypercholestereolaemia. I have been a committee member of the Simon Broome UK FH register since 1991 and have co-authored a number of key papers from the Register documenting the natural history and the underlining molecular causes of the disease. We have developed and applyed high-throughput methods for mutation screening, and have established a clinical genetics service for FH and the DNA diagnostic laboratory in the Institute of Child Health London, which has been running since 1995 with over 900 referrals to-date. Recently, this has resulted in the commercial development of a simple, quick and cheap kit to test for 20 common FH-causing mutations that will detect the mutation in ~450% of patients. In 1996, we established a website database for all known LDLR mutations (http://www.ucl.ac.uk/fh) and this database, which was updated in July 2007, now contains 1000 different molecular causes of FH and is regularly receiving more than 1000 hits/month worldwide. We have developed assays to test both for sequence changes effecting promoter strength and splicing to determine causality of identified sequence changes. With colleagues at the LSHTM, we demonstrated convincingly the cost effectiveness of cascade testing for FH and with other colleagues at King's have examined the psychological impact of genetic testing in FH families. This influenced government thinking such that the White Paper in 2003 "Our inheritance our Future" included a commitment to a pilot project for cascade testing in the UK, and we headed the coordinating centre for this project. A report of this work was sent to the Department of Health in October 2007 and the data obtained has had a major impact on shaping the recommendations of the NICE guidelines for the identification and management of FH which was published in August 2008 and for which I was the lead clinical advisor. With the Royal College of Physicians I am currently developing an audit of the management of FH patients in the UK, and all these outputs taken together will have a significant beneficial impact on the management of this high risk group of subjects.both healthy men and women and of patients with heart disease collected through collaboration with clinical and epidemiological colleagues.

Research Activities

Cardiovascular Genetics

Cell stress proteins as extracellular signals

Critical Care Medicine

Disease of the oral mucosa, salivary glands and jaw bones

characterisation of the genetic and immunological

Education Description

KEY PERSONNEL: Philippa Talmud, Fotios Drenos, Steve Humphries.

The group has a strong commitment to offering high quality training in cardiovascular genetics. We see this as an important component of our work, as we are one of the only groups in the country able to offer training in the molecular biology, molecular genetics, cell biology, genetic epidemiology, and pathophysiology of cardiovascular disease. This is mainly at the post-graduate level, although the lecturers in the group (currently Prof. Talmud and Prof Humphries) each give 3-5 lectures in undergraduate courses every year. We usually have at least two BSc student projects being supervised every year, often medical students doing an intercalated year. We also offer one-two projects per year to MSc students, several of whom have gone on to apply for a PhD in the cardiovascular field. We aim to have at least two PhD students and one MD Fellow start in the group every year and over the last five years 7 PhD and 1 MD theses have been completed, with all students currently pursuing research or clinical careers, with 5 current PhD students and 3 MD students registered (see below).

I strongly believe that the training aspect of our activities is valuable and worthwhile in developing the intellectual base for continued excellence in cardiovascular research in the UK, and this will continue over the next five years.

UCL Collaborators

Dr Mike Grocott; Dr Geoffrey Bellingan; Prof Patricia Woo; Prof Mark Peters; Prof Philippa Talmud; Prof Brian Henderson; Prof Stephen Porter; Prof Hugh Montgomery; Prof John Martin; Prof Mervyn Singer; Prof David Isenberg; Prof Stan Newman; Prof Monty Mythen; Dr Daniel Swerdlow; Dr Stefano Fedele; Prof Timothy Arnett; Prof Lucy Wedderburn; Prof Andrew Steptoe; Prof Aroon Hingorani; Dr Ann Walker

External Collaborators

Publications

    2014

    • Boardman-Pretty FA, Smith AJP, Frankel P, Evans IM, Zachary IC, Hamsten A, Gertow K, Humphries SE (2014). FUNCTIONAL ANALYSIS OF THE BCAR1-CFDP1-TMEM170A LOCUS ASSOCIATED WITH CAROTID INTIMA-MEDIA THICKNESS AND PLAQUE.
    • Humphries SE (2014). Editor in Chief's report for Atherosclerosis for 2013.. Atherosclerosis, 232(1), 254 - 256. doi:10.1016/j.atherosclerosis.2013.12.001
    • Timpson NJ, Walter K, Min JL, Tachmazidou I, Malerba G, Shin SY, Chen L, Futema M, Southam L, Iotchkova V, Cocca M, Huang J, Memari Y, McCarthy S, Danecek P, Muddyman D, Mangino M, Menni C, Perry JR, Ring SM, Gaye A, Dedoussis G, Farmaki AE, Burton P, Talmud PJ, Gambaro G, Spector TD, Smith GD, Durbin R, Richards JB, Humphries SE, Zeggini E, Soranzo N, UK1OK consortium members , UK1OK consortium members (2014). A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans.. Nat Commun, 5, 4871 - . doi:10.1038/ncomms5871
    • Holmes MV, Frikke-Schmidt R, Melis D, Luben R, Asselbergs FW, Boer JM, Cooper J, Palmen J, Horvat P, Engmann J, Li KW, Onland-Moret NC, Hofker MH, Kumari M, Keating BJ, Hubacek JA, Adamkova V, Kubinova R, Bobak M, Khaw KT, Nordestgaard BG, Wareham N, Humphries SE, Langenberg C, Tybjaerg-Hansen A, Talmud PJ (2014). A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease.. Atherosclerosis, 237(1), 5 - 12. doi:10.1016/j.atherosclerosis.2014.07.038
    • Vimaleswaran KS, Cavadino A, Berry DJ, LifeLines Cohort Study investigators , Jorde R, Dieffenbach AK, Lu C, Alves AC, Heerspink HJ, Tikkanen E, Eriksson J, Wong A, Mangino M, Jablonski KA, Nolte IM, Houston DK, Ahluwalia TS, van der Most PJ, Pasko D, Zgaga L, Thiering E, Vitart V, Fraser RM, Huffman JE, de Boer RA, Schöttker B, Saum KU, McCarthy MI, Dupuis J, Herzig KH, Sebert S, Pouta A, Laitinen J, Kleber ME, Navis G, Lorentzon M, Jameson K, Arden N, Cooper JA, Acharya J, Hardy R, Raitakari O, Ripatti S, Billings LK, Lahti J, Osmond C, Penninx BW, Rejnmark L, Lohman KK, Paternoster L, Stolk RP, Hernandez DG, Byberg L, Hagström E, Melhus H, Ingelsson E, Mellström D, Ljunggren O, Tzoulaki I, McLachlan S, Theodoratou E, Tiesler CM, Jula A, Navarro P, Wright AF, Polasek O, International Consortium for Blood Pressure (ICBP) , Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium , Global Blood Pressure Genetics (Global BPGen) consortium , Caroline Hayward , Wilson JF, Rudan I, Salomaa V, Heinrich J, Campbell H, Price JF, Karlsson M, Lind L, Michaëlsson K, Bandinelli S, Frayling TM, Hartman CA, Sørensen TI, Kritchevsky SB, Langdahl BL, Eriksson JG, Florez JC, Spector TD, Lehtimäki T, Kuh D, Humphries SE, Cooper C, Ohlsson C, März W, de Borst MH, Kumari M, Kivimaki M, Wang TJ, Power C, Brenner H, Grimnes G, van der Harst P, Snieder H, Hingorani AD, Pilz S, Whittaker JC, Järvelin MR, Hyppönen E (2014). Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.. Lancet Diabetes Endocrinol, , - . doi:10.1016/S2213-8587(14)70113-5
    • Talmud PJ, Futema M, Humphries SE (2014). The genetic architecture of the familial hyperlipidaemia syndromes: rare mutations and common variants in multiple genes.. Curr Opin Lipidol, 25(4), 274 - 281. doi:10.1097/MOL.0000000000000090
    • Futema M, Plagnol V, Li K, Whittall RA, Neil HA, Seed M, on behalf of the Simon Broome Consortium , Bertolini S, Calandra S, Descamps OS, Graham CA, Hegele RA, Karpe F, Durst R, Leitersdorf E, Lench N, Nair DR, Soran H, Van Bockxmeer FM, UK10K Consortium , Humphries SE (2014). Whole exome sequencing of familial hypercholesterolaemia patients negative for LDLR/APOB/PCSK9 mutations.. J Med Genet, , - . doi:10.1136/jmedgenet-2014-102405
    • Holmes MV, Dale CE, Zuccolo L, Silverwood RJ, Guo Y, Ye Z, Prieto-Merino D, Dehghan A, Trompet S, Wong A, Cavadino A, Drogan D, Padmanabhan S, Li S, Yesupriya A, Leusink M, Sundstrom J, Hubacek JA, Pikhart H, Swerdlow DI, Panayiotou AG, Borinskaya SA, Finan C, Shah S, Kuchenbaecker KB, Shah T, Engmann J, Folkersen L, Eriksson P, Ricceri F, Melander O, Sacerdote C, Gamble DM, Rayaprolu S, Ross OA, McLachlan S, Vikhireva O, Sluijs I, Scott RA, Adamkova V, Flicker L, Bockxmeer FM, Power C, Marques-Vidal P, Meade T, Marmot MG, Ferro JM, Paulos-Pinheiro S, Humphries SE, Talmud PJ, Mateo Leach I, Verweij N, Linneberg A, Skaaby T, Doevendans PA, Cramer MJ, Harst PV, Klungel OH, Dowling NF, Dominiczak AF, Kumari M, Nicolaides AN, Weikert C, Boeing H, Ebrahim S, Gaunt TR, Price JF, Lannfelt L, Peasey A, Kubinova R, Pajak A, Malyutina S, Voevoda MI, Tamosiunas A, Maitland-van der Zee AH, Norman PE, Hankey GJ, Bergmann MM, Hofman A, Franco OH, Cooper J, Palmen J, Spiering W, Jong PA, Kuh D, Hardy R, Uitterlinden AG, Ikram MA, Ford I, Hyppönen E, Almeida OP, Wareham NJ, Khaw KT, Hamsten A, Husemoen LL, Tjønneland A, Tolstrup JS, Rimm E, Beulens JW, Verschuren WM, Onland-Moret NC, Hofker MH, Wannamethee SG, Whincup PH, Morris R, Vicente AM, Watkins H, Farrall M, Jukema JW, Meschia J, Cupples LA, Sharp SJ, Fornage M, Kooperberg C, LaCroix AZ, Dai JY, Lanktree MB, Siscovick DS, Jorgenson E, Spring B, Coresh J, Li YR, Buxbaum SG, Schreiner PJ, Ellison RC, Tsai MY, Patel SR, Redline S, Johnson AD, Hoogeveen RC, Hakonarson H, Rotter JI, Boerwinkle E, Bakker PI, Kivimaki M, Asselbergs FW, Sattar N, Lawlor DA, Whittaker J, Davey Smith G, Mukamal K, Psaty BM, Wilson JG, Lange LA, Hamidovic A, Hingorani AD, Nordestgaard BG, Bobak M, Leon DA, Langenberg C, Palmer TM, Reiner AP, Keating BJ, Dudbridge F, Casas JP, InterAct Consortium (2014). Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.. BMJ, 349, g4164 - .
    • Kassner U, Wühle-Demuth M, Missala I, Humphries SE, Steinhagen-Thiessen E, Demuth I (2014). Clinical utility gene card for: Hyperlipoproteinemia, TYPE II.. Eur J Hum Genet, 22(7), - . doi:10.1038/ejhg.2013.271
    • Skipworth JR, Nijmeijer RM, van Santvoort HC, Besselink MG, Schulz HU, Kivimaki M, Kumari M, Cooper JA, Acharya J, Shankar A, Malago M, Humphries SE, Olde Damink SW, Montgomery HE (2014). The Effect of Renin Angiotensin System Genetic Variants in Acute Pancreatitis.. Ann Surg, , - . doi:10.1097/SLA.0000000000000655
    • Holmes MV, Exeter HJ, Folkersen L, Nelson CP, Guardiola M, Cooper JA, Sofat R, Boekholdt SM, Khaw KT, Li KW, Smith AJ, Van't Hooft F, Eriksson P, Franco-Cereceda A, Asselbergs FW, Boer JM, Onland-Moret NC, Hofker M, Erdmann J, Kivimaki M, Kumari M, Reiner AP, Keating BJ, Humphries SE, Hingorani AD, Mallat Z, Samani NJ, Talmud PJ (2014). A Novel Genetic Approach to Investigate the Role of Plasma Secretory Phospholipase A2 (sPLA2)-V Isoenzyme in Coronary Heart Disease: A Modified Mendelian Randomization Analysis Using PLA2G5 Expression Levels.. Circ Cardiovasc Genet, , - . doi:10.1161/CIRCGENETICS.113.000271
    • Holmes MV, Asselbergs FW, Palmer TM, Drenos F, Lanktree MB, Nelson CP, Dale CE, Padmanabhan S, Finan C, Swerdlow DI, Tragante V, van Iperen EP, Sivapalaratnam S, Shah S, Elbers CC, Shah T, Engmann J, Giambartolomei C, White J, Zabaneh D, Sofat R, McLachlan S, on behalf of the UCLEB consortium , Doevendans PA, Balmforth AJ, Hall AS, North KE, Almoguera B, Hoogeveen RC, Cushman M, Fornage M, Patel SR, Redline S, Siscovick DS, Tsai MY, Karczewski KJ, Hofker MH, Verschuren WM, Bots ML, van der Schouw YT, Melander O, Dominiczak AF, Morris R, Ben-Shlomo Y, Price J, Kumari M, Baumert J, Peters A, Thorand B, Koenig W, Gaunt TR, Humphries SE, Clarke R, Watkins H, Farrall M, Wilson JG, Rich SS, de Bakker PI, Lange LA, Davey Smith G, Reiner AP, Talmud PJ, Kivimäki M, Lawlor DA, Dudbridge F, Samani NJ, Keating BJ, Hingorani AD, Casas JP (2014). Mendelian randomization of blood lipids for coronary heart disease.. Eur Heart J, , - . doi:10.1093/eurheartj/eht571
    • Leigh SEA, Lee YP, Whittall RA, Dawson N, Das S, Martin ACR, Orengo CA, Humphries SE (2014). UPDATE AND ANALYSIS OF THE UCL PRO-PROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE9 GENE (PCSK9) VARIANT DATABASE.
    • Cuchel M, Bruckert E, Ginsberg HN, Raal FJ, Santos RD, Hegele RA, Kuivenhoven JA, Nordestgaard BG, Descamps OS, Steinhagen-Thiessen E, Tybjrg-Hansen A, Watts GF, Averna M, Boileau C, Boren J, Catapano AL, Defesche JC, Hovingh GK, Humphries SE, Kovanen PT, Masana L, Pajukanta P, Parhofer KG, Ray KK, Stalenhoef AFH, Stroes E, Taskinen M-R, Wiegman A, Wiklund O, Chapman MJ, Conse EAS (2014). Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society. EUROPEAN HEART JOURNAL, 35(32), 2146 - U100. doi:10.1093/eurheartj/ehu274
    • Beaney KE, Li K, Cooper JA, Stephens JW, Humphries SE (2014). INVESTIGATING THE RELATIONSHIP BETWEEN RS10911021 AND OXIDATIVE STRESS.
    • Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, Fall T, Fehrmann R, Ferreira T, Jackson AU, Karjalainen J, Lo KS, Locke AE, Mägi R, Mihailov E, Porcu E, Randall JC, Scherag A, Vinkhuyzen AA, Westra HJ, Winkler TW, Workalemahu T, Zhao JH, Absher D, Albrecht E, Anderson D, Baron J, Beekman M, Demirkan A, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Fraser RM, Goel A, Gong J, Justice AE, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Lui JC, Mangino M, Leach IM, Medina-Gomez C, Nalls MA, Nyholt DR, Palmer CD, Pasko D, Pechlivanis S, Prokopenko I, Ried JS, Ripke S, Shungin D, Stancáková A, Strawbridge RJ, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Afzal U, Arnlöv J, Arscott GM, Bandinelli S, Barrett A, Bellis C, Bennett AJ, Berne C, Blüher M, Bolton JL, Böttcher Y, Boyd HA, Bruinenberg M, Buckley BM, Buyske S, Caspersen IH, Chines PS, Clarke R, Claudi-Boehm S, Cooper M, Daw EW, De Jong PA, Deelen J, Delgado G, Denny JC, Dhonukshe-Rutten R, Dimitriou M, Doney AS, Dörr M, Eklund N, Eury E, Folkersen L, Garcia ME, Geller F, Giedraitis V, Go AS, Grallert H, Grammer TB, Gräßler J, Grönberg H, de Groot LC, Groves CJ, Haessler J, Hall P, Haller T, Hallmans G, Hannemann A, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hemani G, Henders AK, Hillege HL, Hlatky MA, Hoffmann W, Hoffmann P, Holmen O, Houwing-Duistermaat JJ, Illig T, Isaacs A, James AL, Jeff J, Johansen B, Johansson A, Jolley J, Juliusdottir T, Junttila J, Kho AN, Kinnunen L, Klopp N, Kocher T, Kratzer W, Lichtner P, Lind L, Lindström J, Lobbens S, Lorentzon M, Lu Y, Lyssenko V, Magnusson PK, Mahajan A, Maillard M, McArdle WL, McKenzie CA, McLachlan S, McLaren PJ, Menni C, Merger S, Milani L, Moayyeri A, Monda KL, Morken MA, Müller G, Müller-Nurasyid M, Musk AW, Narisu N, Nauck M, Nolte IM, Nöthen MM, Oozageer L, Pilz S, Rayner NW, Renstrom F, Robertson NR, Rose LM, Roussel R, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Schunkert H, Scott RA, Sehmi J, Seufferlein T, Shi J, Silventoinen K, Smit JH, Smith AV, Smolonska J, Stanton AV, Stirrups K, Stott DJ, Stringham HM, Sundström J, Swertz MA, Syvänen AC, Tayo BO, Thorleifsson G, Tyrer JP, van Dijk S, van Schoor NM, van der Velde N, van Heemst D, van Oort FV, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Waldenberger M, Wennauer R, Wilkens LR, Willenborg C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q, Arveiler D, Bakker SJ, Beilby J, Bergman RN, Bergmann S, Biffar R, Blangero J, Boomsma DI, Bornstein SR, Bovet P, Brambilla P, Brown MJ, Campbell H, Caulfield MJ, Chakravarti A, Collins R, Collins FS, Crawford DC, Cupples LA, Danesh J, de Faire U, den Ruijter HM, Erbel R, Erdmann J, Eriksson JG, Farrall M, Ferrannini E, Ferrières J, Ford I, Forouhi NG, Forrester T, Gansevoort RT, Gejman PV, Gieger C, Golay A, Gottesman O, Gudnason V, Gyllensten U, Haas DW, Hall AS, Harris TB, Hattersley AT, Heath AC, Hengstenberg C, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Hovingh GK, Humphries SE, Hunt SC, Hypponen E, Jacobs KB, Jarvelin MR, Jousilahti P, Jula AM, Kaprio J, Kastelein JJ, Kayser M, Kee F, Keinanen-Kiukaanniemi SM, Kiemeney LA, Kooner JS, Kooperberg C, Koskinen S, Kovacs P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lupoli S, Madden PA, Männistö S, Manunta P, Marette A, Matise TC, McKnight B, Meitinger T, Moll FL, Montgomery GW, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Ouwehand WH, Pasterkamp G, Peters A, Pramstaller PP, Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ritchie M, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schwarz PE, Sebert S, Sev (2014). Defining the role of common variation in the genomic and biological architecture of adult human height.. Nat Genet, , - . doi:10.1038/ng.3097
    • Zain M, Cooper JA, Li KW, Palmen J, Acharya J, Howard P, Ireland H, Humphries SE, Awan FR, Baig SM, Elkeles RS, Stephens JW (2014). Association of TLL1 gene polymorphism (rs1503298, T > C) with coronary heart disease in PREDICT, UDACS and ED Cohorts. Journal of the College of Physicians and Surgeons Pakistan, 24(9), 615 - 619.
    • Khamis A, Palmen J, Lench N, Taylor A, Badmus E, Leigh S, Humphries SE (2014). Functional analysis of four LDLR 5'UTR and promoter variants in patients with familial hypercholesterolaemia.. Eur J Hum Genet, , - . doi:10.1038/ejhg.2014.199
    • Gigante B, Leander K, Vikström M, Baldassarre D, Veglia F, Strawbridge RJ, McLeod O, Gertow K, Sennblad B, Shah S, Zabaneh D, Humphries SE, Kauhanen J, Rauramaa R, Smit AJ, Mannarino E, Giral P, Tremoli E, Hamsten A, Frostegård J, de Faire U, on behalf of the IMPROVE Study Group (2014). Low levels of IgM antibodies against phosphorylcholine are associated with fast carotid intima media thickness progression and cardiovascular risk in men.. Atherosclerosis, 236(2), 394 - 399. doi:10.1016/j.atherosclerosis.2014.07.030
    • Saxena R, Bjonnes A, Lane J, Prescott J, Hunter DJ, De Vivo I, Dib P, Natt P, Salpea KD, Sanghera DK, Lerner M, Brackett D, Stowell D, Peyton M, Kraft P, Cooper JA, Li KW, Maubaret CG, Humphries SE, Ye Y, Gu J, Wu X, Codd V, Mangino M, Samani NJ, Spector TD, Mirabello L, Savage SA, Dinney CP, Ralhan S, Wander GS, Mehra NK (2014). Genome-Wide Association Study Identifies Variants in Casein Kinase II (CSNK2A2) to be Associated With Leukocyte Telomere Length in a Punjabi Sikh Diabetic Cohort. Circulation: Cardiovascular Genetics, 7(3), 287 - 295. doi:10.1161/CIRCGENETICS.113.000412
    • Sabater-Lleal M, Mälarstig A, Folkersen L, Soler Artigas M, Baldassarre D, Kavousi M, Almgren P, Veglia F, Brusselle G, Hofman A, Engström G, Franco OH, Melander O, Paulsson-Berne G, Watkins H, Eriksson P, Humphries SE, Tremoli E, de Faire U, Tobin MD, Hamsten A (2014). Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease.. PLoS One, 9(8), e104082 - . doi:10.1371/journal.pone.0104082
    • Söderström LA, Gertow K, Folkersen L, Sabater-Lleal M, Sundman E, Sheikine Y, Goel A, Baldassarre D, Humphries SE, De Faire U, Watkins H, Tremoli E, Veglia F, Hamsten A, Hansson GK, Olofsson PS (2014). Human genetic evidence for involvement of CD137 in atherosclerosis.. Mol Med, , - . doi:10.2119/molmed.2014.00004
    • Strawbridge RJ, Deleskog A, McLeod O, Folkersen L, Kavousi M, Gertow K, Baldassarre D, Veglia F, Leander K, Gigante B, Kauhanen J, Rauramaa R, Smit AJ, Mannarino E, Giral P, Dehghan A, Hofman A, Franco OH, Humphries SE, Tremoli E, de Faire U, Gustafsson S, Ostensson C-G, Eriksson P, Ohrvik J, Hamsten A (2014). A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima-media thickness). DIABETOLOGIA, 57(6), 1159 - 1172. doi:10.1007/s00125-014-3215-y
    • Versmissen J, Oosterveer DM, Yazdanpanah M, Dehghan A, Hólm H, Erdman J, Aulchenko YS, Thorleifsson G, Schunkert H, Huijgen R, Vongpromek R, Uitterlinden AG, Defesche JC, van Duijn CM, Mulder M, Dadd T, Karlsson HD, Ordovas J, Kindt I, Jarman A, Hofman A, van Vark-van der Zee L, Blommesteijn-Touw AC, Kwekkeboom J, Liem AH, van der Ouderaa FJ, Calandra S, Bertolini S, Averna M, Langslet G, Ose L, Ros E, Almagro F, de Leeuw PW, Civeira F, Masana L, Pintó X, Simoons ML, Schinkel AF, Green MR, Zwinderman AH, Johnson KJ, Schaefer A, Neil A, Witteman JC, Humphries SE, Kastelein JJ, Sijbrands EJ (2014). Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach.. Eur J Hum Genet, , - . doi:10.1038/ejhg.2014.101
    • Masi S, Gkranias N, Li K, Salpea KD, Parkar M, Orlandi M, Suvan JE, Eng HL, Taddei S, Patel K, Darbar U, Donos N, Deanfield JE, Hurel S, Humphries SE, D'Aiuto F (2014). Association between short leukocyte telomere length, endotoxemia, and severe periodontitis in people with diabetes: a cross-sectional survey.. Diabetes Care, 37(4), 1140 - 1147. doi:10.2337/dc13-2106
    • Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MCY, Prokopenko I, Saleheen D, Wang X, Zeggini E, Abecasis GR, Adair LS, Almgren P, Atalay M, Aung T, Baldassarre D, Balkau B, Bao Y, Barnett AH, Barroso I, Basit A, Been LF, Beilby J, Bell GI, Benediktsson R, Bergman RN, Boehm BO, Boerwinkle E, Bonnycastle LL, Burtt N, Cai Q, Campbell H, Carey J, Cauchi S, Caulfield M, Chan JCN, Chang L-C, Chang T-J, Chang Y-C, Charpentier G, Chen C-H, Chen H, Chen Y-T, Chia K-S, Chidambaram M, Chines PS, Cho NH, Cho YM, Chuang L-M, Collins FS, Cornelis MC, Couper DJ, Crenshaw AT, van Dam RM, Danesh J, Das D, de Faire U, Dedoussis G, Deloukas P, Dimas AS, Dina C, Doney ASF, Donnelly PJ, Dorkhan M, van Duijn C, Dupuis J, Edkins S, Elliott P, Emilsson V, Erbel R, Eriksson JG, Escobedo J, Esko T, Eury E, Florez JC, Fontanillas P, Forouhi NG, Forsen T, Fox C, Fraser RM, Frayling TM, Froguel P, Frossard P, Gao Y, Gertow K, Gieger C, Gigante B, Grallert H, Grant GB, Groop LC, Groves CJ, Grundberg E, Guiducci C, Hamsten A, Han B-G, Hara K, Hassanali N, Hattersley AT, Hayward C, Hedman AK, Herder C, Hofman A, Holmen OL, Hovingh K, Hreidarsson AB, Hu C, Hu FB, Hui J, Humphries SE, Hunt SE, Hunter DJ, Hveem K, Hydrie ZI, Ikegami H, Illig T, Ingelsson E, Islam M, Isomaa B, Jackson AU, Jafar T, James A, Jia W, Joeckel K-H, Jonsson A, Jowett JBM, Kadowaki T, Kang HM, Kanoni S, Kao WHL, Kathiresan S, Kato N, Katulanda P, Keinanen-Kiukaanniemi SM, Kelly AM, Khan H, Khaw K-T, Khor C-C, Kim H-L, Kim S, Kim YJ, Kinnunen L, Klopp N, Kong A, Korpi-Hyovalti E, Kowlessur S, Kraft P, Kravic J, Kristensen MM, Krithika S, Kumar A, Kumate J, Kuusisto J, Kwak SH, Laakso M, Lagou V, Lakka TA, Langenberg C, Langford C, Lawrence R, Leander K, Lee J-M, Lee NR, Li M, Li X, Li Y, Liang J, Liju S, Lim W-Y, Lind L, Lindgren CM, Lindholm E, Liu C-T, Liu JJ, Lobbens S, Long J, Loos RJF, Lu W, Luan J, Lyssenko V, Ma RCW, Maeda S, Maegi R, Mannisto S, Matthews DR, Meigs JB, Melander O, Metspalu A, Meyer J, Mirza G, Mihailov E, Moebus S, Mohan V, Mohlke KL, Morris AD, Muehleisen TW, Mueller-Nurasyid M, Musk B, Nakamura J, Nakashima E, Navarro P, Ng P-K, Nica AC, Nilsson PM, Njolstad I, Noethen MM, Ohnaka K, Ong TH, Owen KR, Palmer CNA, Pankow JS, Park KS, Parkin M, Pechlivanis S, Pedersen NL, Peltonen L, Perry JRB, Peters A, Pinidiyapathirage JM, Platou CGP, Potter S, Price JF, Qi L, Radha V, Rallidis L, Rasheed A, Rathmann W, Rauramaa R, Raychaudhuri S, Rayner NW, Rees SD, Rehnberg E, Ripatti S, Robertson N, Roden M, Rossin EJ, Rudan I, Rybin D, Saaristo TE, Salomaa V, Saltevo J, Samuel M, Sanghera DK, Saramies J, Scott J, Scott LJ, Scott RA, Segre AV, Sehmi J, Sennblad B, Shah N, Shah S, Shera AS, Shu XO, Shuldiner AR, Sigurdsson G, Sijbrands E, Silveira A, Sim X, Sivapalaratnam S, Small KS, So WY, Stancakova A, Stefansson K, Steinbach G, Steinthorsdottir V, Stirrups K, Strawbridge RJ, Stringham HM, Sun Q, Suo C, Syvanen A-C, Takayanagi R, Takeuchi F, Tay WT, Teslovich TM, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tikkanen E, Trakalo J, Tremoli E, Trip MD, Tsai FJ, Tuomi T, Tuomilehto J, Uitterlinden AG, Valladares-Salgado A, Vedantam S, Veglia F, Voight BF, Wang C, Wareham NJ, Wennauer R, Wickremasinghe AR, Wilsgaard T, Wilson JF, Wiltshire S, Winckler W, Wong TY, Wood AR, Wu J-Y, Wu Y, Yamamoto K, Yamauchi T, Yang M, Yengo L, Yokota M, Young R, Zabaneh D, Zhang F, Zhang R, Zheng W, Zimmet PZ, Altshuler D, Bowden DW, Cho YS, Cox NJ, Cruz M, Hanis CL, Kooner J, Lee J-Y, Seielstad M, Teo YY, Boehnke M, Parra EJ, Chambers JC, Tai ES, McCarthy MI, Morris AP, Meta DGR, Network AGE, Cons SATDS, Mexican AT2DMC, Exploration T2DG (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. NATURE GENETICS, 46(3), 234 - +. doi:10.1038/ng.2897
    • McLeod O, Silveira A, Fredrikson GN, Gertow K, Baldassarre D, Veglia F, Sennblad B, Strawbridge RJ, Larsson M, Leander K, Gigante B, Kauhanen J, Rauramaa R, Smit AJ, Mannarino E, Giral P, Humphries SE, Tremoli E, de Faire U, Ohrvik J, Nilsson J, Hamsten A (2014). Plasma autoantibodies against apolipoprotein B-100 peptide 210 in subclinical atherosclerosis.. Atherosclerosis, 232(1), 242 - 248. doi:10.1016/j.atherosclerosis.2013.11.041
    • Swerdlow DI, Preiss D, Kuchenbaecker KB, Holmes MV, Engmann JEL, Shah T, Sofat R, Stender S, Johnson PCD, Scott RA, Leusink M, Verweij N, Sharp SJ, Guo Y, Giambartolomei C, Chung C, Peasey A, Amuzu A, Li K, Palmen J, Howard P, Cooper JA, Drenos F, Li YR, Lowe G, Gallacher J, Stewart MCW, Tzoulaki I, Buxbaum SG, van der A DL, Forouhi NG, Onland-Moret NC, van der Schouw YT, Schnabel RB, Hubacek JA, Kubinova R, Baceviciene M, Tamosiunas A, Pajak A, Topor-Madry R, Stepaniak U, Malyutina S, Baldassarre D, Sennblad B, Tremoli E, de Faire U, Veglia F, Ford I, Jukema JW, Westendorp RGJ, de Borst GJ, de Jong PA, Algra A, Spiering W, der Zee AHM-V, Klungel OH, de Boer A, Doevendans PA, Eaton CB, Robinson JG, Duggan D, Kjekshus J, Downs JR, Gotto AM, Keech AC, Marchioli R, Tognoni G, Sever PS, Poulter NR, Waters DD, Pedersen TR, Amarenco P, Nakamura H, McMurray JJV, Lewsey JD, Chasman DI, Ridker PM, Maggioni AP, Tavazzi L, Ray KK, Seshasai SRK, Manson JE, Price JF, Whincup PH, Morris RW, Lawlor DA, Smith GD, Ben-Shlomo Y, Schreiner PJ, Fornage M, Siscovick DS, Cushman M, Kumari M, Wareham NJ, Verschuren WMM, Redline S, Patel SR, Whittaker JC, Hamsten A, Delaney JA, Dale C, Gaunt TR, Wong A, Kuh D, Hardy R, Kathiresan S, Castillo BA, van der Harst P, Brunner EJ, Tybjaerg-Hansen A, Marmot MG, Krauss RM, Tsai M, Coresh J, Hoogeveen RC, Psaty BM, Lange LA, Hakonarson H, Dudbridge F, Humphries SE, Talmud PJ, Kivimäki M, Timpson NJ, Langenberg C, Asselbergs FW, Voevoda M, Bobak M, Pikhart H, Wilson JG, Reiner AP, Keating BJ, Hingorani AD, Sattar N (2014). HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. The Lancet, , - . doi:10.1016/S0140-6736(14)61183-1

    2013

    • Gaunt TR, Zabaneh D, Shah S, Guyatt A, Ladroue C, Kumari M, Drenos F, Shah T, Talmud PJ, Casas JP, Lowe G, Rumley A, Lawlor DA, Kivimaki M, Whittaker J, Hingorani AD, Humphries SE, Day IN (2013). Gene-centric association signals for haemostasis and thrombosis traits identified with the HumanCVD BeadChip.. Thromb Haemost, 110(5), 995 - 1003. doi:10.1160/TH13-02-0087
    • Shah S, Casas JP, Gaunt TR, Cooper J, Drenos F, Zabaneh D, Swerdlow DI, Shah T, Sofat R, Palmen J, Kumari M, Kivimaki M, Ebrahim S, Smith GD, Lawlor DA, Talmud PJ, Whittaker J, Day IN, Hingorani AD, Humphries SE (2013). Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies.. Eur Heart J, 34(13), 972 - 981. doi:10.1093/eurheartj/ehs243
    • Global Lipids Genetics Consortium , Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkilä K, Hyppönen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikäinen LP, Magnusson PK, Mangino M, Mihailov E, Montasser ME, Müller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney AS, Döring A, Elliott P, Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJ, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimäki T, Lin SY, Lindström J, Loos RJ, Mach F, McArdle WL, Meisinger C, Mitchell BD, Müller G, Nagaraja R, Narisu N, Nieminen TV, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stancáková A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YD, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrières J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Järvelin MR, Jula A, Kähönen M, Kaprio J, Kesäniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, März W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njølstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PE, Sheu WH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BH, Ordovas JM, Boerwinkle E, Palmer CN, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Kathiresan S, Mohlke KL, Ingelsson E, Abecasis GR (2013). Discovery and refinement of loci associated with lipid levels.. Nat Genet, , - . doi:10.1038/ng.2797
    • Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Croteau-Chonka DC, Day FR, Fall T, Ferreira T, Gustafsson S, Locke AE, Mathieson I, Scherag A, Vedantam S, Wood AR, Liang L, Steinthorsdottir V, Thorleifsson G, Dermitzakis ET, Dimas AS, Karpe F, Min JL, Nicholson G, Clegg DJ, Person T, Krohn JP, Bauer S, Buechler C, Eisinger K, DIAGRAM Consortium , Bonnefond A, Froguel P, MAGIC Investigators , Hottenga JJ, Prokopenko I, Waite LL, Harris TB, Smith AV, Shuldiner AR, McArdle WL, Caulfield MJ, Munroe PB, Grönberg H, Chen YD, Li G, Beckmann JS, Johnson T, Thorsteinsdottir U, Teder-Laving M, Khaw KT, Wareham NJ, Zhao JH, Amin N, Oostra BA, Kraja AT, Province MA, Cupples LA, Heard-Costa NL, Kaprio J, Ripatti S, Surakka I, Collins FS, Saramies J, Tuomilehto J, Jula A, Salomaa V, Erdmann J, Hengstenberg C, Loley C, Schunkert H, Lamina C, Wichmann HE, Albrecht E, Gieger C, Hicks AA, Johansson A, Pramstaller PP, Kathiresan S, Speliotes EK, Penninx B, Hartikainen AL, Jarvelin MR, Gyllensten U, Boomsma DI, Campbell H, Wilson JF, Chanock SJ, Farrall M, Goel A, Medina-Gomez C, Rivadeneira F, Estrada K, Uitterlinden AG, Hofman A, Zillikens MC, den Heijer M, Kiemeney LA, Maschio A, Hall P, Tyrer J, Teumer A, Völzke H, Kovacs P, Tönjes A, Mangino M, Spector TD, Hayward C, Rudan I, Hall AS, Samani NJ, Attwood AP, Sambrook JG, Hung J, Palmer LJ, Lokki ML, Sinisalo J, Boucher G, Huikuri H, Lorentzon M, Ohlsson C, Eklund N, Eriksson JG, Barlassina C, Rivolta C, Nolte IM, Snieder H, Van der Klauw MM, Van Vliet-Ostaptchouk JV, Gejman PV, Shi J, Jacobs KB, Wang Z, Bakker SJ, Mateo Leach I, Navis G, van der Harst P, Martin NG, Medland SE, Montgomery GW, Yang J, Chasman DI, Ridker PM, Rose LM, Lehtimäki T, Raitakari O, Absher D, Iribarren C, Basart H, Hovingh KG, Hyppönen E, Power C, Anderson D, Beilby JP, Hui J, Jolley J, Sager H, Bornstein SR, Schwarz PE, Kristiansson K, Perola M, Lindström J, Swift AJ, Uusitupa M, Atalay M, Lakka TA, Rauramaa R, Bolton JL, Fowkes G, Fraser RM, Price JF, Fischer K, Krjutå Kov K, Metspalu A, Mihailov E, Langenberg C, Luan J, Ong KK, Chines PS, Keinanen-Kiukaanniemi SM, Saaristo TE, Edkins S, Franks PW, Hallmans G, Shungin D, Morris AD, Palmer CN, Erbel R, Moebus S, Nöthen MM, Pechlivanis S, Hveem K, Narisu N, Hamsten A, Humphries SE, Strawbridge RJ, Tremoli E, Grallert H, Thorand B, Illig T, Koenig W, Müller-Nurasyid M, Peters A, Boehm BO, Kleber ME, März W, Winkelmann BR, Kuusisto J, Laakso M, Arveiler D, Cesana G, Kuulasmaa K, Virtamo J, Yarnell JW, Kuh D, Wong A, Lind L, de Faire U, Gigante B, Magnusson PK, Pedersen NL, Dedoussis G, Dimitriou M, Kolovou G, Kanoni S, Stirrups K, Bonnycastle LL, Njølstad I, Wilsgaard T, Ganna A, Rehnberg E, Hingorani A, Kivimaki M, Kumari M, Assimes TL, Barroso I, Boehnke M, Borecki IB, Deloukas P, Fox CS, Frayling T, Groop LC, Haritunians T, Hunter D, Ingelsson E, Kaplan R, Mohlke KL, O'Connell JR, Schlessinger D, Strachan DP, Stefansson K, van Duijn CM, Abecasis GR, McCarthy MI, Hirschhorn JN, Qi L, Loos RJ, Lindgren CM, North KE, Heid IM (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits.. PLoS Genet, 9(6), e1003500 - . doi:10.1371/journal.pgen.1003500
    • Shah T, Engmann J, Finan C, Holmes MV, Kumari M, Kivimaki M, Casas JP, Hingorani AD, Dale C, Amuzu A, Warren H, Ebrahim S, Dudbridge F, Shah S, White J, Giambartolomei C, Zabaneh D, Plagnol V, McLachlan S, Price J, Cavadino A, Power C, Hypponen E, Wong A, Ong K, Richards M, Hardy R, Kuh D, Wareham N, Gaunt T, Davies T-L, Lawlor DA, Day IN, Drenos F, Cooper J, Talmud PJ, Humphries SE, Sofat R, Caulfield M, Ben-Shlomo Y, Whincup P, Morris R, Strachan MWJ, Whittaker JC (2013). Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. PLoS ONE, 8(8), - . doi:10.1371/journal.pone.0071345
    • Holmes MV, Simon T, Exeter HJ, Folkersen L, Asselbergs FW, Guardiola M, Cooper JA, Palmen J, Hubacek JA, Carruthers KF, Horne BD, Brunisholz KD, Mega JL, van Iperen EP, Li M, Leusink M, Trompet S, Verschuren JJ, Hovingh GK, Dehghan A, Nelson CP, Kotti S, Danchin N, Scholz M, Haase CL, Rothenbacher D, Swerdlow DI, Kuchenbaecker KB, Staines-Urias E, Goel A, Hooft FV, Gertow K, de Faire U, Panayiotou AG, Tremoli E, Baldassarre D, Veglia F, Holdt LM, Beutner F, Gansevoort RT, Navis GJ, Leach IM, Breitling LP, Brenner H, Dallmeier D, Franco-Cereceda A, Boer J, Stephens JW, Hofker MH, Tedgui A, Hofman A, Uitterlinden AG, Adamkova V, Pitha J, Onland-Moret NC, Cramer MJ, Nathoe HM, Spiering W, Klungel OH, Kumari M, Whincup PH, Morrow DA, Braund PS, Hall AS, Olsson AG, Doevendans PA, Trip MD, Tobin MD, Hamsten A, Watkins H, Koenig W, Nicolaides AN, Teupser D, Day IN, Carlquist JF, Gaunt TR, Ford I, Sattar N, Tsimikas S, Schwartz GG, Lawlor DA, Morris RW, Sandhu MS, Poledne R, Maitland-van der Zee AH, Khaw KT, Keating BJ, van der Harst P, Price JF, Mehta SR, Yusuf S, Witteman JC, Franco OH, Jukema JW, de Knijff P, Tybjaerg-Hansen A, Rader DJ, Farrall M, Samani J, Kivimaki M, Fox KA, Humphries SE, Anderson JL, Boekholdt SM, Palmer TM, Eriksson P, Paré G, Hingorani AD, Sabatine MS, Mallat Z, Casas JP, Talmud PJ (2013). Secretory Phospholipase A2-IIA and Cardiovascular Disease: a Mendelian randomization study.. J Am Coll Cardiol, , - . doi:10.1016/j.jacc.2013.06.044
    • Harrison SC, Holmes MV, Asselbergs FW, Bown MJ, Baas AF, Grettarsdottir S, Jones GT, Humphries SE, Study SMART, Consortium A, Study U, Study I, Study NZ (2013). High-density lipoprotein cholesterol and abdominal aortic aneurysm a mendelian randomisation study.
    • Khan TA, Shah T, Prieto D, Zhang W, Price J, Fowkes GR, Cooper J, Talmud PJ, Humphries SE, Sundstrom J, Hubacek JA, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Abdollahi MR, Slooter AJ, Szolnoki Z, Sandhu M, Wareham N, Frikke-Schmidt R, Tybjærg-Hansen A, Fillenbaum G, Heijmans BT, Katsuya T, Gromadzka G, Singleton A, Ferrucci L, Hardy J, Worrall B, Rich SS, Matarin M, Whittaker J, Gaunt TR, Whincup P, Morris R, Deanfield J, Donald A, Davey Smith G, Kivimaki M, Kumari M, Smeeth L, Khaw KT, Nalls M, Meschia J, Sun K, Hui R, Day I, Hingorani AD, Casas JP (2013). Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals.. Int J Epidemiol, 42(2), 475 - 492. doi:10.1093/ije/dyt034
    • Shah T, Zabaneh D, Gaunt T, Swerdlow DI, Shah S, Talmud PJ, Day IN, Whittaker J, Holmes MV, Sofat R, Humphries SE, Kivimaki M, Kumari M, Hingorani AD, Casas JP (2013). Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.. Circ Cardiovasc Genet, 6(2), 163 - 170. doi:10.1161/CIRCGENETICS.112.964254
    • Talmud PJ, Shah S, Whittall R, Futema M, Howard P, Cooper JA, Harrison SC, Li K, Drenos F, Karpe F, Neil HA, Descamps OS, Langenberg C, Lench N, Kivimaki M, Whittaker J, Hingorani AD, Kumari M, Humphries SE (2013). Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study.. Lancet, 381(9874), 1293 - 1301. doi:10.1016/S0140-6736(12)62127-8
    • Shah S, Casas JP, Drenos F, Whittaker J, Deanfield J, Swerdlow DI, Holmes MV, Kivimaki M, Langenberg C, Wareham N, Gertow K, Sennblad B, Strawbridge RJ, Baldassarre D, Veglia F, Tremoli E, Gigante B, de Faire U, Kumari M, Talmud PJ, Hamsten A, Humphries SE, Hingorani AD (2013). Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis.. Circ Cardiovasc Genet, 6(1), 63 - 72. doi:10.1161/CIRCGENETICS.112.963140
    • Harrison SC, Smith AJ, Jones GT, Swerdlow DI, Rampuri R, Bown MJ, Aneurysm Consortium , Folkersen L, Baas AF, de Borst GJ, Blankensteijn JD, Price JF, van der Graaf Y, McLachlan S, Agu O, Hofman A, Uitterlinden AG, Franco-Cereceda A, Ruigrok YM, van't Hof FN, Powell JT, van Rij AM, Casas JP, Eriksson P, Holmes MV, Asselbergs FW, Hingorani AD, Humphries SE (2013). Interleukin-6 receptor pathways in abdominal aortic aneurysm.. Eur Heart J, 34(48), 3707 - 3716. doi:10.1093/eurheartj/ehs354
    • Pang DX, Smith AJ, Humphries SE (2013). Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes.. Nutr Metab Cardiovasc Dis, 23(6), 550 - 556. doi:10.1016/j.numecd.2011.12.012
    • Hegele RA, Ginsberg HN, Chapman MJ, Nordestgaard BG, Kuivenhoven JA, Averna M, Borén J, Bruckert E, Catapano AL, Descamps OS, Hovingh GK, Humphries SE, Kovanen PT, Masana L, Pajukanta P, Parhofer KG, Raal FJ, Ray KK, Santos RD, Stalenhoef AF, Stroes E, Taskinen MR, Tybjærg-Hansen A, Watts GF, Wiklund O, on behalf of the European Atherosclerosis Society Consensus Panel (2013). The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management.. Lancet Diabetes Endocrinol, , - . doi:10.1016/S2213-8587(13)70191-8
    • Bradley DT, Hughes AE, Badger SA, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, Gretarsdottir S, Burnand K, Child AH, Clough RE, Cockerill G, Hafez H, Scott DJ, Ariëns RA, Johnson A, Sohrabi S, Smith A, Thompson MM, van Bockxmeer FM, Waltham M, Matthiasson SE, Thorleifsson G, Thorsteinsdottir U, Blankensteijn JD, Teijink JA, Wijmenga C, de Graaf J, Kiemeney LA, Wild JB, Edkins S, Gwilliam R, Hunt SE, Potter S, Lindholt JS, Golledge J, Norman PE, van Rij A, Powell JT, Eriksson P, Stefansson K, Thompson JR, Humphries SE, Sayers RD, Deloukas P, Samani NJ, Bown MJ (2013). A Variant in LDLR is Associated with Abdominal Aortic Aneurysm.. Circ Cardiovasc Genet, , - . doi:10.1161/CIRCGENETICS.113.000165
    • Nordestgaard BG, Chapman MJ, Humphries SE, Ginsberg HN, Masana L, Descamps OS, Wiklund O, Hegele RA, Raal FJ, Defesche JC, Wiegman A, Santos RD, Watts GF, Parhofer KG, Hovingh GK, Kovanen PT, Boileau C, Averna M, Boren J, Bruckert E, Catapano AL, Kuivenhoven JA, Pajukanta P, Ray K, Stalenhoef AFH, Stroes E, Taskinen M-R, Tybjaerg-Hansen A, Conse EAS (2013). Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease. EUROPEAN HEART JOURNAL, 34(45), 3478 - +. doi:10.1093/eurheartj/eht273
    • Brice P, Burton H, Edwards CW, Humphries SE, Aitman TJ (2013). Familial hypercholesterolaemia: A pressing issue for European health care. ATHEROSCLEROSIS, 231(2), 223 - 226. doi:10.1016/j.atherosclerosis.2013.09.019
    • Wright CF, Middleton A, Burton H, Cunningham F, Humphries SE, Hurst J, Birney E, Firth HV (2013). Policy challenges of clinical genome sequencing. BMJ-BRITISH MEDICAL JOURNAL, 347, - . doi:10.1136/bmj.f6845
    • Maubaret CG, Salpea KD, Romanoski CE, Folkersen L, Cooper JA, Stephanou C, Wah Li K, Palmen J, Hamsten A, Neil A, Stephens JW, Lusis AJ, Eriksson P, Talmud PJ, Humphries SE, Simon Broome Research Group , the EARSII consortium (2013). Association of TERC and OBFC1 Haplotypes with Mean Leukocyte Telomere Length and Risk for Coronary Heart Disease.. PLoS One, 8(12), e83122 - . doi:10.1371/journal.pone.0083122
    • Panayiotou AG, Griffin MB, Tyllis T, Georgiou N, Bond D, Humphries SE, Nicolaides AN (2013). Association of genotypes at the matrix metalloproteinase (MMP) loci with carotid IMT and presence of carotid and femoral atherosclerotic plaques. VASCULAR MEDICINE, 18(5), 298 - 306. doi:10.1177/1358863X13502698
    • Dweck MR, Lee PT, Prasher S, Shah AS, Humphries SE, Pennell DJ, Montgomery H, Payne J (2013). Response to Letter About Article, "Left Ventricular Wall Thickness and the Presence of Asymmetric Hypertrophy in Healthy Young Army Recruits: Data From the LARGE Heart Study". CIRCULATION-CARDIOVASCULAR IMAGING, 6(5), E29 - E29. doi:10.1161/CIRCIMAGING.113.000773
    • Deleskog A, Piksasova O, Silveira A, Gertow K, Baldassarre D, Veglia F, Sennblad B, Strawbridge RJ, Larsson M, Leander K, Gigante B, Kauhanen J, Rauramaa R, Smit AJ, Mannarino E, Giral P, Gustafsson S, Ostenson CG, Humphries SE, Tremoli E, de Faire U, Ohrvik J, Hamsten A (2013). Serum 25-Hydroxyvitamin D Concentration in Subclinical Carotid Atherosclerosis.. Arterioscler Thromb Vasc Biol, , - . doi:10.1161/ATVBAHA.113.301593
    • Salpea KD, Maubaret CG, Kathagen A, Ken-Dror G, Gilroy DW, Humphries SE (2013). The Effect of Pro-Inflammatory Conditioning and/or High Glucose on Telomere Shortening of Aging Fibroblasts.. PLoS One, 8(9), e73756 - . doi:10.1371/journal.pone.0073756
    • Baldassarre D, Veglia F, Hamsten A, Humphries SE, Rauramaa R, de Faire U, Smit AJ, Giral P, Kurl S, Mannarino E, Grossi E, Paoletti R, Tremoli E, Grp IMPROVES (2013). Progression of Carotid Intima-Media Thickness as Predictor of Vascular Events Results from the IMPROVE Study. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(9), 2273 - 2279. doi:10.1161/ATVBAHA.113.301844
    • Lee PT, Dweck MR, Prasher S, Shah A, Humphries SE, Pennell DJ, Montgomery HE, Payne JR (2013). Left Ventricular Wall Thickness and the Presence of Asymmetric Hypertrophy in Healthy Young Army Recruits Data From the LARGE Heart Study. CIRCULATION-CARDIOVASCULAR IMAGING, 6(2), 262 - 267. doi:10.1161/CIRCIMAGING.112.979294
    • Futema M, Whittall RA, Kiley A, Steel LK, Cooper JA, Badmus E, Leigh SE, Karpe F, Neil HA, Simon Broome Register Group , Humphries SE (2013). Analysis of the frequency and spectrum of mutations recognised to cause familial hypercholesterolaemia in routine clinical practice in a UK specialist hospital lipid clinic.. Atherosclerosis, 229(1), 161 - 168. doi:10.1016/j.atherosclerosis.2013.04.011
    • Woo P, Humphries SE (2013). IL-6 polymorphisms: a useful genetic tool for inflammation research?. JOURNAL OF CLINICAL INVESTIGATION, 123(4), 1413 - 1414. doi:10.1172/JCI67221
    • Harrison SC, Holmes MV, Bown MJ, Jones GT, Grettarsdottir S, Agu O, Van Rij A, Asselbergs FW, Baas AF, Humphries SE (2013). High-density lipoprotein cholesterol and abdominal aortic aneurysm - a Mendelian randomisation study.
    • Dieckmann M, Beil FT, Mueller B, Bartelt A, Marshall RP, Koehne T, Amling M, Ruether W, Cooper JA, Humphries SE, Herz J, Niemeier A (2013). Human Apolipoprotein E Isoforms Differentially Affect Bone Mass and Turnover In Vivo. JOURNAL OF BONE AND MINERAL RESEARCH, 28(2), 236 - 245. doi:10.1002/jbmr.1757
    • Ahmed W, Whittall R, Riaz M, Ajmal M, Sadeque A, Ayub H, Qamar R, Humphries SE (2013). The genetic spectrum of familial hypercholesterolemia in Pakistan.. Clin Chim Acta, 421, 219 - 225. doi:10.1016/j.cca.2013.03.017
    • Cambridge G, Acharya J, Cooper JA, Edwards JC, Humphries SE (2013). Antibodies to citrullinated peptides and risk of coronary heart disease.. Atherosclerosis, 228(1), 243 - 246. doi:10.1016/j.atherosclerosis.2013.02.009
    • Humphries SE (2013). Out with print in with e publication: editor in chief's report for Atherosclerosis for 2012.. Atherosclerosis, 226(1), 1 - 2. doi:10.1016/j.atherosclerosis.2012.12.004
    • Eleftheriou KI, Rawal JS, James LE, Payne JR, Loosemore M, Pennell DJ, World M, Drenos F, Haddad FS, Humphries SE, Sanders J, Montgomery HE (2013). Bone structure and geometry in young men: the influence of smoking, alcohol intake and physical activity.. Bone, 52(1), 17 - 26. doi:10.1016/j.bone.2012.09.003
    • Do R, Gao C, Kathiresan S, Saxena R, Altshuler D, Peloso GM, Fontanillas P, Daly MJ, Neale BM, Willer CJ, Schmidt EM, Sengupta S, Chen J, Bragg-Gresham JL, Jackson AU, Teslovich TM, Boehnke M, Abecasis GR, Gustafsson S, Ganna A, Song C, Siegbahn A, Ingelsson E, Kanoni S, Stirrups K, Deloukas P, Magnusson PKE, Pedersen NL, Buchkovich ML, Wu Y, Mohlke KL, Mora S, Ridker PM, Chasman DI, Beckmann JS, Chang H-Y, Demirkan A, Den Hertog HM, Van den Herik EG, Koudstaal PJ, Donnelly LA, Doney ASF, Morris AD, Palmer CNA, Ehret GB, Chakravarti A, Esko T, Palmer CD, Vedantam S, Hirschhorn JN, Fischer K, Mihailov E, Metspalu A, Feitosa MF, Borecki IB, Ferreira T, Lindgren CM, Fraser RM, Bolton JL, Rudan I, Wild SH, Wilson JF, Campbell H, Price JF, Freitag DF, Gurdasani D, Papamarkou T, Pomilla C, Wainwright N, Young EH, Danesh J, Sandhu MS, Barroso I, Ripatti S, Heikkilä K, Hyppönen E, Power C, Isaacs A, van Duijn CM, Johansson A, Johnson T, Munroe PB, Kaakinen M, Järvelin M-R, Kettunen J, Surakka I, Palotie A, Silander K, Perola M, Kleber ME, Li X, Kim E, Rotter JI, Luan J, Langenberg C, Zhao JH, Wareham NJ, Lyytikäinen L-P, Lehtimäki T, Mangino M, Spector TD, Montasser ME, O'Connell JR, Mitchell BD, Müller-Nurasyid M, Nolte IM, Kaprio J, Petersen A-K, Gieger C, Sanna S, Sidore C, Service SK, Shah S, Kumari M, Hingorani A, Kivimaki M, Shungin D, Franks PW, Strawbridge RJ, Hamsten A, Tanaka T, Ferrucci L, Thorleifsson G, Holm H, Voight BF, Volcik KA, Boerwinkle E, Waite LL, Absher D, Wong A, Ong KK, Kuh D, Zhang W, Chambers JC, Asiki G, Kaleebu P, Nsubuga RN, Been LF, Gravito ML, Sanghera DK, Bonnycastle LL, Narisu N, Swift AJ, Collins FS, Brambilla P, Burnett MS, Epstein SE, Cesana G, Dimitriou M, Dedoussis G, Döring A, Elliott P, Eyjolfsson GI, Gigante B, de Faire U, Goodarzi MO, Jones MR, Grallert H, Groves CJ, McCarthy MI, Hallmans G, Hartikainen A-L, Hayward C, Hernandez D, Hicks AA, Hung Y-J, Illig T, Klopp N, Kastelein JJP, Hovingh GK, Khaw K-T, Komulainen P, Lin S-Y, Lindström J, Loos RJF, Mach F, McArdle WL, Meisinger C, Müller G, Nagaraja R, Nieminen TVM, Olafsson I, Pouta A, Rader DJ, Reilly MP, Rivadeneira F, Uitterlinden AG, Hofman A, Ruokonen A, Samani N, Scharnagl H, März W, Seeley J, Stančáková A, Kuusisto J, Laakso M, Tiret L, van Pelt LJ, Wijmenga C, Wolffenbuttel BHR, Willemsen G, Boomsma DI, Wilsgaard T, Njølstad I, Adair LS, Arveiler D, Assimes TL, Quertermous T, Bandinelli S, Bennett F, Bochud M, Boehm BO, Bornstein SR, Bovet P, Burnier M, Kooner JS, Chen Y-DI, Cooper RS, Tayo BO, Feranil AB, Ferrières J, Freimer NB, Groop LC, Gudnason V, Gyllensten U, Harris TB, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Jula A, Kähönen M, Kesäniemi A, Krauss RM, Kyvik KO, Lakka TA, Rauramaa R, Lind L, Wallentin L, Martin NG, Whitfield JB, McKenzie CA, Meneton P, Moilanen L, Pramstaller PP, Psaty BM, Saleheen D, Salomaa V, Saramies J, Schwarz PEH, Sheu WH-H, Shuldiner AR, Stefansson K, Thorsteinsdottir U, Strachan DP, Tremoli E, Tuomilehto J, Uusitupa M, Vollenweider P, Ordovas JM, Cupples LA, Rich SS (2013). Common variants associated with plasma triglycerides and risk for coronary artery disease. Nature Genetics, , - . doi:10.1038/ng.2795

    2012

    • Humphries SE (2012). Out with print in with e publication: Editor in Chief's Report for Atherosclerosis for 2012.. Atherosclerosis, , - . doi:10.1016/j.atherosclerosis.2012.12.004
    • Harrison SC, Cooper JA, Li K, Talmud PJ, Sofat R, Stephens JW, Hamsten A, HIFMECH Consortium , Sanders J, Montgomery H, Neil A, Simon Broome Research Consortium , Humphries SE (2012). Association of a sequence variant in DAB2IP with coronary heart disease.. Eur Heart J, 33(7), 881 - 888. doi:10.1093/eurheartj/ehr075
    • Costelloe SJ, El-Sayed Moustafa JS, Drenos F, Palmen J, Li Q, Whiting S, Thomas M, Kivimaki M, Kumari M, Hingorani AD, Tzoulaki I, Järvelin MR, Ruokonen A, Hartikainen AL, Pouta A, Walters RG, Blakemore AI, Humphries SE, Coin LJ, Talmud PJ (2012). Gene-targeted analysis of copy number variants identifies 3 novel associations with coronary heart disease traits.. Circ Cardiovasc Genet, 5(5), 555 - 560. doi:10.1161/CIRCGENETICS.111.961037
    • Futema M, Plagnol V, Whittall RA, Neil HA, Simon Broome Register Group , Humphries SE, UK10K (2012). Use of targeted exome sequencing as a diagnostic tool for Familial Hypercholesterolaemia.. J Med Genet, 49(10), 644 - 649. doi:10.1136/jmedgenet-2012-101189
    • Masi S, Nightingale CM, Day IN, Guthrie P, Rumley A, Lowe GD, von Zglinicki T, D'Aiuto F, Taddei S, Klein N, Salpea K, Cook DG, Humphries SE, Whincup PH, Deanfield JE (2012). Inflammation and not cardiovascular risk factors is associated with short leukocyte telomere length in 13- to 16-year-old adolescents.. Arterioscler Thromb Vasc Biol, 32(8), 2029 - 2034. doi:10.1161/ATVBAHA.112.250589
    • Harrison SC, Holmes MV, Humphries SE (2012). Mendelian randomisation, lipids, and cardiovascular disease.. Lancet, 380(9841), 543 - 545. doi:10.1016/S0140-6736(12)60481-4
    • Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium , Hingorani AD, Casas JP (2012). The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.. Lancet, 379(9822), 1214 - 1224. doi:10.1016/S0140-6736(12)60110-X
    • Ken-Dror G, Humphries SE, Kumari M, Kivimaki M, Drenos F (2012). A genetic instrument for Mendelian randomization of fibrinogen.. Eur J Epidemiol, 27(4), 267 - 279. doi:10.1007/s10654-012-9666-x
    • Harrison SC, Zabaneh D, Drenos F, Bown MJ, Gertow K, Baldassare D, Asselbergs FW, Jones GT, Baas AF, Kumari M, Fowkes FG, Eriksson P, Hamsten A, Humphries SE (2012). Genetic determinants of vascular diameter and the risk of abdominal aortic aneurysm.
    • Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA, Li YR, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight BF, Balasubramanyam A, Barnard J, Bauer F, Baumert J, Bhangale T, Böhm BO, Braund PS, Burton PR, Chandrupatla HR, Clarke R, Cooper-DeHoff RM, Crook ED, Davey-Smith G, Day IN, de Boer A, de Groot MC, Drenos F, Ferguson J, Fox CS, Furlong CE, Gibson Q, Gieger C, Gilhuijs-Pederson LA, Glessner JT, Goel A, Gong Y, Grant SF, Grobbee DE, Hastie C, Humphries SE, Kim CE, Kivimaki M, Kleber M, Meisinger C, Kumari M, Langaee TY, Lawlor DA, Li M, Lobmeyer MT, Maitland-van der Zee AH, Meijs MF, Molony CM, Morrow DA, Murugesan G, Musani SK, Nelson CP, Newhouse SJ, O'Connell JR, Padmanabhan S, Palmen J, Patel SR, Pepine CJ, Pettinger M, Price TS, Rafelt S, Ranchalis J, Rasheed A, Rosenthal E, Ruczinski I, Shah S, Shen H, Silbernagel G, Smith EN, Spijkerman AW, Stanton A, Steffes MW, Thorand B, Trip M, van der Harst P, van der A DL, van Iperen EP, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Wolffenbuttel BH, Young T, Zafarmand MH, Zmuda JM, Look AHEAD Research Group , DIAGRAM consortium , Boehnke M, Altshuler D, McCarthy M, Kao WH, Pankow JS, Cappola TP, Sever P, Poulter N, Caulfield M, Dominiczak A, Shields DC, Bhatt DL, Zhang L, Curtis SP, Danesh J, Casas JP, van der Schouw YT, Onland-Moret NC, Doevendans PA, Dorn GW, Farrall M, FitzGerald GA, Hamsten A, Hegele R, Hingorani AD, Hofker MH, Huggins GS, Illig T, Jarvik GP, Johnson JA, Klungel OH, Knowler WC, Koenig W, März W, Meigs JB, Melander O, Munroe PB, Mitchell BD, Bielinski SJ, Rader DJ, Reilly MP, Rich SS, Rotter JI, Saleheen D, Samani NJ, Schadt EE, Shuldiner AR, Silverstein R, Kottke-Marchant K, Talmud PJ, Watkins H, Asselbergs FW, de Bakker PI, McCaffery J, Wijmenga C, Sabatine MS, Wilson JG, Reiner A, Bowden DW, Hakonarson H, Siscovick DS, Keating BJ (2012). Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.. Am J Hum Genet, 90(3), 410 - 425. doi:10.1016/j.ajhg.2011.12.022
    • Harrison SC, Zabaneh D, Asselbergs FW, Drenos F, Jones GT, Shah S, Gertow K, Sennblad B, Strawbridge RJ, Gigante B, Holewijn S, De Graaf J, Vermeulen S, Folkersen L, van Rij AM, Baldassarre D, Veglia F, Talmud PJ, Deanfield JE, Agu O, Kivimaki M, Kumari M, Bown MJ, Nyyssönen K, Rauramaa R, Smit AJ, Franco-Cereceda A, Giral P, Mannarino E, Silveira A, Syvänen A-C, de Borst GJ, van der Graaf Y, de Faire U, Baas AF, Blankensteijn JD, Wareham NJ, Fowkes G, Tzoulaki I, Price JF, Tremoli E, Hingorani AD, Eriksson P, Hamsten A, Humphries SE (2012). A gene-centric study of common carotid artery remodelling. Atherosclerosis, , - .
    • Papp AC, Pinsonneault JK, Wang D, Newman LC, Gong Y, Johnson JA, Pepine CJ, Kumari M, Hingorani AD, Talmud PJ, Shah S, Humphries SE, Sadee W (2012). Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk.. PLoS One, 7(3), e31930 - . doi:10.1371/journal.pone.0031930
    • Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni S, Kumar A, Lagou V, Langenberg C, Luan J, Lindgren CM, Müller-Nurasyid M, Pechlivanis S, Rayner NW, Scott LJ, Wiltshire S, Yengo L, Kinnunen L, Rossin EJ, Raychaudhuri S, Johnson AD, Dimas AS, Loos RJF, Vedantam S, Chen H, Florez JC, Fox C, Liu C-T, Rybin D, Couper DJ, Kao WHL, Li M, Cornelis MC, Kraft P, Sun Q, Van Dam RM, Stringham HM, Chines PS, Fischer K, Fontanillas P, Holmen OL, Hunt SE, Jackson AU, Kong A, Lawrence R, Meyer J, Perry JRB, Platou CGP, Potter S, Rehnberg E, Robertson N, Sivapalaratnam S, Stančáková A, Stirrups K, Thorleifsson G, Tikkanen E, Wood AR, Almgren P, Atalay M, Benediktsson R, Bonnycastle LL, Burtt N, Carey J, Charpentier G, Crenshaw AT, Doney ASF, Dorkhan M, Edkins S, Emilsson V, Eury E, Forsen T, Gertow K, Gigante B, Grant GB, Groves CJ, Guiducci C, Herder C, Hreidarsson AB, Hui J, James A, Jonsson A, Rathmann W, Klopp N, Kravic J, Krjutškov K, Langford C, Leander K, Lindholm E, Lobbens S, MäNnistö S, Mirza G, MüHleisen TW, Musk B, Parkin M, Rallidis L, Saramies J, Sennblad B, Shah S, Sigursson G, Silveira A, Steinbach G, Thorand B, Trakalo J, Veglia F, Wennauer R, Winckler W, Zabaneh D, Campbell H, Van Duijn C, Uitterlinden AG, Hofman A, Sijbrands E, Abecasis GR, Owen KR, Zeggini E, Trip MD, Forouhi NG, Syvänen A-C, Eriksson JG, Peltonen L, Nöthen MM, Balkau B, Palmer CNA, Lyssenko V, Tuomi T, Isomaa B, Hunter DJ, Qi L, Shuldiner AR, Roden M, Barroso I, Wilsgaard T, Beilby J, Hovingh K, Price JF, Wilson JF, Rauramaa R, Lakka TA, Lind L, Dedoussis G, NjøLstad I, Pedersen NL, Khaw K-T, Wareham NJ, Keinanen-Kiukaanniemi SM, Saaristo TE, Korpi-HyöVäLti E, Saltevo J, Laakso M, Kuusisto J, Metspalu A, Collins FS, Mohlke KL, Bergman RN, Tuomilehto J, Boehm BO, Gieger C, Hveem K, Cauchi S, Froguel P, Baldassarre D, Tremoli E, Humphries SE, Saleheen D, Danesh J, Ingelsson E, Ripatti S, Salomaa V, Erbel R, JöCkel K-H, Moebus S, Peters A, Illig T, Faire UD, Hamsten A, Morris AD, Donnelly PJ, Frayling TM, Hattersley AT, Boerwinkle E, Melander O, Kathiresan S, Nilsson PM, Deloukas P, Thorsteinsdottir U, Groop LC, Stefansson K, Hu F, Pankow JS, Dupuis J, Meigs JB, Altshuler D, Boehnke M, McCarthy MI (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 44(9), 981 - 990.
    • Asselbergs F, Guo Y, van Iperen EA, Sivapalaratnam S, Tragante V, Lanktree M, Lange L, Almoguera B, Appelman Y, Barnard J, Baumert J, Beitelshees A, Bhangale T, Chen Y-D, Gaunt T, Gong Y, Hopewell J, Johnson T, Kleber M, Langaee T, Li M, Li Y, Liu K, McDonough C, Meijs ML, Middelberg RS, Musunuru K, Nelson C, O'Connell J, Padmanabhan S, Pankow J, Pankratz N, Rafelt S, Rajagopalan R, Romaine SR, Schork N, Shaffer J, Shen H, Smith E, Tischfield S, van der Most P, van Vliet-Ostaptchouk J, Verweij N, Volcik K, Zhang L, Bailey K, Bailey K, Bauer F, Boer JA, Braund P, Burt A, Burton P, Buxbaum S, Chen W, Cooper-DeHoff R, Cupples L, deJong J, Delles C, Duggan D, Fornage M, Furlong C, Glazer N, Gums J, Hastie C, Holmes M, Illig T, Kirkland S, Kivimaki M, Klein R, Klein B, Kooperberg C, Kottke-Marchant K, Kumari M, LaCroix A, Mallela L, Murugesan G, Ordovas J, Ouwehand W, Post W, Saxena R, Scharnagl H, Schreiner P, Shah T, Shields D, Shimbo D, Srinivasan S, Stolk R, Swerdlow D, Taylor Jr H, Topol E, Toskala E, van Pelt J, van Setten J, Yusuf S, Whittaker J, Zwinderman AH, Anand S, Balmforth A, Berenson G, Bezzina C, Boehm B, Boerwinkle E, Casas J, Caulfield M, Clarke R, Connell J, Cruickshanks K, Davidson K, Day IM, de Bakker PW, Doevendans P, Dominiczak A, Hall A, Hartman C, Hengstenberg C, Hillege H, Hofker M, Humphries S, Jarvik G, Johnson J, Kaess B, Kathiresan S, Koenig W, Lawlor D, März W, Melander O, Mitchell B, Montgomery G, Munroe P, Murray S, Newhouse S, Onland-Moret N, Poulter N, Psaty B, Redline S, Rich S, Rotter J, Schunkert H, Sever P, Shuldiner A, Silverstein R, Stanton A, Thorand B, Trip M, Tsai M, van der Harst P, van der Schoot E, van der Schouw Y, Verschuren WM, Watkins H, Wilde AM, Wolffenbuttel BR, Whitfield J, Hovingh G, Ballantyne C, Wijmenga C, Reilly M, Martin N, Wilson J, Rader D, Samani N, Reiner A, Hegele R, Kastelein JP, Hingorani A, Talmud P, Hakonarson H, Elbers C, Keating B, Drenos F (2012). Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. American Journal of Human Genetics, , - .
    • Smith AJP, Howard P, Palmen J, Talmud PJ, Humphries SE, Shah S, Giambartolomei C, Eriksson P, Folkersen L, Stender S, Tybjærg-Hansen A, Kumari M, Hingorani AD (2012). Use of Allele-Specific FAIRE to Determine Functional Regulatory Polymorphism Using Large-Scale Genotyping Arrays. PLoS Genetics, 8(8), - . doi:10.1371/journal.pgen.1002908
    • Yiannakouris N, Cooper JA, Shah S, Drenos F, Ireland HA, Stephens JW, Li KW, Elkeles R, Godsland IF, Kivimaki M, Hingorani AD, Kumari M, Talmud PJ, Humphries SE (2012). IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.. Nutr Metab Cardiovasc Dis, 22(12), 1024 - 1030. doi:10.1016/j.numecd.2011.05.009
    • Angelakopoulou A, Shah T, Sofat R, Shah S, Berry DJ, Cooper J, Palmen J, Tzoulaki I, Wong A, Jefferis BJ, Maniatis N, Drenos F, Gigante B, Hardy R, Laxton RC, Leander K, Motterle A, Simpson IA, Smeeth L, Thomson A, Verzilli C, Kuh D, Ireland H, Deanfield J, Caulfield M, Wallace C, Samani N, Munroe PB, Lathrop M, Fowkes FG, Marmot M, Whincup PH, Whittaker JC, de Faire U, Kivimaki M, Kumari M, Hypponen E, Power C, Humphries SE, Talmud PJ, Price J, Morris RW, Ye S, Casas JP, Hingorani AD (2012). Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.. Eur Heart J, 33(3), 393 - 407. doi:10.1093/eurheartj/ehr225
    • Dhamrait SS, Williams AG, Day SH, Skipworth J, Payne JR, World M, Humphries SE, Montgomery HE (2012). Variation in the uncoupling protein 2 and 3 genes and human performance.. J Appl Physiol (1985), 112(7), 1122 - 1127. doi:10.1152/japplphysiol.00766.2011
    • Humphries SE (2012). Out with print in with e publication: Editor in Chief's Report for Atherosclerosis for 2012.. Atherosclerosis, , - . doi:10.1016/j.atherosclerosis.2012.12.004
    • Baldassarre D, Hamsten A, Veglia F, de Faire U, Humphries SE, Smit AJ, Giral P, Kurl S, Rauramaa R, Mannarino E, Grossi E, Paoletti R, Tremoli E, Grp IMPROVES (2012). Measurements of Carotid Intima-Media Thickness and of Interadventitia Common Carotid Diameter Improve Prediction of Cardiovascular Events Results of the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) Study. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 60(16), 1489 - 1499. doi:10.1016/j.jacc.2012.06.034
    • Smith AJ, Zheng D, Palmen J, Pang DX, Woo P, Humphries SE (2012). Effects of genetic variation on chromatin structure and the transcriptional machinery: analysis of the IL6 gene locus.. Genes Immun, 13(7), 583 - 586. doi:10.1038/gene.2012.32
    • Walker AP, Fowkes RC, Saleh F, Kim SH, Wilkinson P, Cabrera-Sharp V, Talmud PJ, Humphries SE, Looijenga LH, Bouloux PM (2012). Genetic analysis of NR0B1 in congenital adrenal hypoplasia patients: identification of a rare regulatory variant resulting in congenital adrenal hypoplasia and hypogonadal hypogonadism without testicular carcinoma in situ.. Sex Dev, 6(6), 284 - 291. doi:10.1159/000342295
    • Futema M, Plagnol V, Whittall RA, Neil HAW, Hurles ME, Humphries SE (2012). Exome sequencing as a diagnostic tool for Familial Hypercholesterolaemia (FH).
    • Nyyssönen K, Kurl S, Karppi J, Nurmi T, Baldassarre D, Veglia F, Rauramaa R, de Faire U, Hamsten A, Smit AJ, Mannarino E, Humphries SE, Giral P, Grossi E, Tremoli E (2012). LDL oxidative modification and carotid atherosclerosis: results of a multicenter study.. Atherosclerosis, 225(1), 231 - 236. doi:10.1016/j.atherosclerosis.2012.08.030
    • Dweck M, Lee PT, Prasher S, World M, Humphries SE, Pennell DJ, Montgomery HE, Payne JR (2012). A normal range for left ventricular wall thickness and the development of asymmetric thickening in response to exercise.
    • Gigante B, Leander K, Strawbridge R, Sennblad B, Veglia F, Baldassarre D, Tremoli E, Humphries SE, Frostegard J, De Faire U, Grp IMPROVES (2012). Low levels of IgM antibodies against phosphorylcholine (anti-PC) increase the risk of ischemic cardiovascular events among European men at high risk of cardiovascular events.
    • Swerdlow DI, Holmes MV, Harrison S, Humphries SE (2012). The genetics of coronary heart disease.. Br Med Bull, 102, 59 - 77. doi:10.1093/bmb/lds009
    • Tang TS, Prior SL, Li KW, Ireland HA, Bain SC, Hurel SJ, Cooper JA, Humphries SE, Stephens JW (2012). Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 22(5), 417 - 425. doi:10.1016/j.numecd.2010.08.001
    • Ahmed W, Ajmal M, Sadeque A, Whittall RA, Rafiq S, Putt W, Khawaja A, Imtiaz F, Ahmed N, Azam M, Humphries SE, Qamar R (2012). Novel and recurrent LDLR gene mutations in Pakistani hypercholesterolemia patients.. Mol Biol Rep, 39(7), 7365 - 7372. doi:10.1007/s11033-012-1568-1
    • Helgadottir A, Gretarsdottir S, Thorleifsson G, Holm H, Gudbjartsson DF, Thorsteinsdottir U, Stefansson K, Magnusson MK, Onundarson PT, Thorgeirsson G, Patel RS, Eapen DJ, Levey AI, Quyyumi AA, Gudnason T, Jones GT, Van Rij AM, Baas AF, Tregouet D-A, Morange P-E, Emmerich J, Lindblad B, Gottster A, Kiemeny LA, Lindholt JS, Sakalihasan N, Ferrell RE, Carey DJ, Tromp G, Kuivaniemi H, Elmore JR, Tsao PS, Grarup N, Hansen T, Pedersen O, Jørgensen T, Witte DR, Pola R, Gaetani E, Magnadottir HB, Wijmenga C, Ronkainen A, Ruigrok YM, Blankensteijn JD, Mueller T, Wells PS, Corral J, Soria JM, Souto JC, Peden JF, Jalilzadeh S, Watkins H, Farrall M, Mayosi BM, Keavney B, Strawbridge RJ, Sabater-Lleal M, Gertow K, Hamsten A, Baldassarre D, Tremoli E, Nyyssnen K, Rauramaa R, Smit AJ, Mannarino E, Giral P, De Faire U, Humphries SE, Haraldsdottir V, Olafsson I, Samani NJ, Markus HS, Kostulas K, Dichgans M, Berger K, Kuhlenbumer G, Ringelstein EB, Stoll M, Seedorf U, Rothwell PM, Powell JT, Valdimarsson E, Matthiasson SE (2012). Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism. Journal of the American College of Cardiology, 60(8), 722 - 729. doi:10.1016/j.jacc.2012.01.078
    • Prior SL, Clark AR, Jones DA, Bain SC, Stephens JW, Hurel SJ, Humphries SE (2012). Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus. Disease Markers, 32(6), 363 - 369. doi:10.3233/DMA-2012-0894
    • Exeter HJ, Folkersen L, Palmen J, Franco-Cereceda A, Cooper JA, Kalea AZ, Hooft FV, Eriksson P, Humphries SE, Talmud PJ (2012). Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels.. PLoS One, 7(7), e41139 - . doi:10.1371/journal.pone.0041139
    • Harrison SC, Kalea AZ, Holmes MV, Agu O, Humphries SE (2012). Genomic research to identify novel pathways in the development of abdominal aortic aneurysm.. Cardiol Res Pract, 2012, 852829 - . doi:10.1155/2012/852829
    • Usifo E, Leigh SE, Whittall RA, Lench N, Taylor A, Yeats C, Orengo CA, Martin AC, Celli J, Humphries SE (2012). Low-density lipoprotein receptor gene familial hypercholesterolemia variant database: update and pathological assessment. Ann Hum Genet, 76, 387-401+ - 387-401+. doi:10.1111/j.1469-1809.2012.00724.x%20%5Bdoi%5D
    • Thompson SR, Humphries SE, Thomas MG, Ekong R, Tarekegn A, Bekele E, Creemer O, Bradman N, Veeramah KR (2012). The frequency of an IL-18-associated haplotype in Africans. Eur J Hum Genet, , - . doi:10.1038/ejhg.2012.184
    • Eleftheriou KI, Rawal JS, Kehoe A, James LE, Payne JR, Skipworth JR, Puthucheary ZA, Drenos F, Pennell DJ, Loosemore M, World M, Humphries SE, Haddad FS, Montgomery HE (2012). The Lichfield bone study: the skeletal response to exercise in healthy young men.. J Appl Physiol (1985), 112(4), 615 - 626. doi:10.1152/japplphysiol.00788.2011
    • Humphries SE (2012). Editor in Chief's Report for Atherosclerosis for 2011.. Atherosclerosis, 220(1), 1 - 2. doi:10.1016/j.atherosclerosis.2011.11.004
    • Martin NG, Li KW, Murray H, Putt W, Packard CJ, Humphries SE (2012). The effects of a single nucleotide polymorphism in SLCO1B1 on the pharmacodynamics of pravastatin.. Br J Clin Pharmacol, 73(2), 303 - 306. doi:10.1111/j.1365-2125.2011.04090.x
    • Sanders JS, Skipworth JR, Cooper JA, Brull DJ, Humphries SE, Mythen M, Montgomery HE (2012). Duration of preceding hypertension is associated with prolonged length of ICU stay.. Int J Cardiol, 157(2), 180 - 184. doi:10.1016/j.ijcard.2010.12.011
    • Gaunt TR, Shah S, Nelson CP, Drenos F, Braund PS, Adeniran I, Folkersen L, Lawlor DA, Casas JP, Amuzu A, Kivimaki M, Whittaker J, Eriksson P, Zhang H, Hancox JC, Tomaszewski M, Burton PR, Tobin MD, Humphries SE, Talmud PJ, Macfarlane PW, Hingorani AD, Samani NJ, Kumari M, Day IN (2012). Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip.. Circ Cardiovasc Genet, 5(6), 630 - 638. doi:10.1161/CIRCGENETICS.112.962852

    2011

    • Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I, O'Brien ET, Poulter NR, Sever P, Shields DC, Thom S, Wannamethee SG, Whincup PH, Brown MJ, Connell JM, Dobson RJ, Howard PJ, Mein CA, Onipinla A, Shaw-Hawkins S, Zhang Y, Davey Smith G, Day IN, Lawlor DA, Goodall AH, Cardiogenics Consortium , Fowkes FG, Abecasis GR, Elliott P, Gateva V, Global BPgen Consortium , Braund PS, Burton PR, Nelson CP, Tobin MD, van der Harst P, Glorioso N, Neuvrith H, Salvi E, Staessen JA, Stucchi A, Devos N, Jeunemaitre X, Plouin PF, Tichet J, Juhanson P, Org E, Putku M, Sõber S, Veldre G, Viigimaa M, Levinsson A, Rosengren A, Thelle DS, Hastie CE, Hedner T, Lee WK, Melander O, Wahlstrand B, Hardy R, Wong A, Cooper JA, Palmen J, Chen L, Stewart AF, Wells GA, Westra HJ, Wolfs MG, Clarke R, Franzosi MG, Goel A, Hamsten A, Lathrop M, Peden JF, Seedorf U, Watkins H, Ouwehand WH, Sambrook J, Stephens J, Casas JP, Drenos F, Holmes MV, Kivimaki M, Shah S, Shah T, Talmud PJ, Whittaker J, Wallace C, Delles C, Laan M, Kuh D, Humphries SE, Nyberg F, Cusi D, Roberts R, Newton-Cheh C, Franke L, Stanton AV, Dominiczak AF, Farrall M, Hingorani AD, Samani NJ, Caulfield MJ, Munroe PB (2011). Blood pressure loci identified with a gene-centric array.. Am J Hum Genet, 89(6), 688 - 700. doi:10.1016/j.ajhg.2011.10.013
    • Holmes MV, Harrison S, Talmud PJ, Hingorani AD, Humphries SE (2011). Utility of genetic determinants of lipids and cardiovascular events in assessing risk.. Nat Rev Cardiol, 8(4), 207 - 221. doi:10.1038/nrcardio.2011.6
    • Futema M, Whittall R, Wood G, Curtis M, McEwan J, Humphries SE (2011). Identification of patients with familial hypercholesterolaemia (FH) through the application of genetic testing in young mi patients from the MINAP register. doi:10.1016/j.atherosclerosis.2011.07.071
    • Shah S, Nelson CP, Gaunt TR, van der Harst P, Barnes T, Braund PS, Lawlor DA, Casas JP, Padmanabhan S, Drenos F, Kivimaki M, Talmud PJ, Humphries SE, Whittaker J, Morris RW, Whincup PH, Dominiczak A, Munroe PB, Johnson T, Goodall AH, Cambien F, Diemert P, Hengstenberg C, Ouwehand WH, Felix JF, Glazer NL, Tomaszewski M, Burton PR, Tobin MD, van Veldhuisen DJ, de Boer RA, Navis G, van Gilst WH, Mayosi BM, Thompson JR, Kumari M, MacFarlane PW, Day IN, Hingorani AD, Samani NJ (2011). Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy.. Circ Cardiovasc Genet, 4(6), 626 - 635. doi:10.1161/CIRCGENETICS.111.960203
    • Holmes MV, Newcombe P, Hubacek JA, Sofat R, Ricketts SL, Cooper J, Breteler MM, Bautista LE, Sharma P, Whittaker JC, Smeeth L, Fowkes FG, Algra A, Shmeleva V, Szolnoki Z, Roest M, Linnebank M, Zacho J, Nalls MA, Singleton AB, Ferrucci L, Hardy J, Worrall BB, Rich SS, Matarin M, Norman PE, Flicker L, Almeida OP, van Bockxmeer FM, Shimokata H, Khaw KT, Wareham NJ, Bobak M, Sterne JA, Smith GD, Talmud PJ, van Duijn C, Humphries SE, Price JF, Ebrahim S, Lawlor DA, Hankey GJ, Meschia JF, Sandhu MS, Hingorani AD, Casas JP (2011). Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials.. Lancet, 378(9791), 584 - 594. doi:10.1016/S0140-6736(11)60872-6
    • Nherera L, Marks D, Minhas R, Thorogood M, Humphries SE (2011). Probabilistic cost-effectiveness analysis of cascade screening for familial hypercholesterolaemia using alternative diagnostic and identification strategies.. Heart, 97(14), 1175 - 1181. doi:10.1136/hrt.2010.213975
    • Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U, Zhou Y, Smith AV, Zhao JH, Amin N, Vedantam S, Shin SY, Haritunians T, Fu M, Feitosa MF, Kumari M, Halldorsson BV, Tikkanen E, Mangino M, Hayward C, Song C, Arnold AM, Aulchenko YS, Oostra BA, Campbell H, Cupples LA, Davis KE, Döring A, Eiriksdottir G, Estrada K, Fernández-Real JM, Garcia M, Gieger C, Glazer NL, Guiducci C, Hofman A, Humphries SE, Isomaa B, Jacobs LC, Jula A, Karasik D, Karlsson MK, Khaw KT, Kim LJ, Kivimäki M, Klopp N, Kühnel B, Kuusisto J, Liu Y, Ljunggren O, Lorentzon M, Luben RN, McKnight B, Mellström D, Mitchell BD, Mooser V, Moreno JM, Männistö S, O'Connell JR, Pascoe L, Peltonen L, Peral B, Perola M, Psaty BM, Salomaa V, Savage DB, Semple RK, Skaric-Juric T, Sigurdsson G, Song KS, Spector TD, Syvänen AC, Talmud PJ, Thorleifsson G, Thorsteinsdottir U, Uitterlinden AG, van Duijn CM, Vidal-Puig A, Wild SH, Wright AF, Clegg DJ, Schadt E, Wilson JF, Rudan I, Ripatti S, Borecki IB, Shuldiner AR, Ingelsson E, Jansson JO, Kaplan RC, Gudnason V, Harris TB, Groop L, Kiel DP, Rivadeneira F, Walker M, Barroso I, Vollenweider P, Waeber G, Chambers JC, Kooner JS, Soranzo N, Hirschhorn JN, Stefansson K, Wichmann HE, Ohlsson C, O'Rahilly S, Wareham NJ, Speliotes EK, Fox CS, Laakso M, Loos RJ (2011). Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.. Nat Genet, 43(8), 753 - 760. doi:10.1038/ng.866
    • Taylor KC, Lange LA, Zabaneh D, Lange E, Keating BJ, Tang W, Smith NL, Delaney JA, Kumari M, Hingorani A, North KE, Kivimaki M, Tracy RP, O'Donnell CJ, Folsom AR, Green D, Humphries SE, Reiner AP (2011). A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium.. Hum Mol Genet, 20(17), 3525 - 3534. doi:10.1093/hmg/ddr264
    • Zabaneh D, Gaunt TR, Kumari M, Drenos F, Shah S, Berry D, Power C, Hypponen E, Shah T, Palmen J, Pallas J, Talmud PJ, Casas JP, Sofat R, Lowe G, Rumley A, Morris RW, Whincup PH, Rodriguez S, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Kivimaki M, Whittaker J, Hingorani AD, Day IN, Humphries SE (2011). Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChip.. Ann Hum Genet, 75(4), 456 - 467. doi:10.1111/j.1469-1809.2011.00654.x
    • Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, van Iperen EP, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, Burton PR, Carty C, Chandrupatla HR, Chen W, Connell J, Dalgeorgou C, Boer AD, Drenos F, Elbers CC, Fang JC, Fox CS, Frackelton EC, Fuchs B, Furlong CE, Gibson Q, Gieger C, Goel A, Grobbee DE, Hastie C, Howard PJ, Huang GH, Johnson WC, Li Q, Kleber ME, Klein BE, Klein R, Kooperberg C, Ky B, Lacroix A, Lanken P, Lathrop M, Li M, Marshall V, Melander O, Mentch FD, Meyer NJ, Monda KL, Montpetit A, Murugesan G, Nakayama K, Nondahl D, Onipinla A, Rafelt S, Newhouse SJ, Otieno FG, Patel SR, Putt ME, Rodriguez S, Safa RN, Sawyer DB, Schreiner PJ, Simpson C, Sivapalaratnam S, Srinivasan SR, Suver C, Swergold G, Sweitzer NK, Thomas KA, Thorand B, Timpson NJ, Tischfield S, Tobin M, Tomaszewski M, Verschuren WM, Wallace C, Winkelmann B, Zhang H, Zheng D, Zhang L, Zmuda JM, Clarke R, Balmforth AJ, Danesh J, Day IN, Schork NJ, de Bakker PI, Delles C, Duggan D, Hingorani AD, Hirschhorn JN, Hofker MH, Humphries SE, Kivimaki M, Lawlor DA, Kottke-Marchant K, Mega JL, Mitchell BD, Morrow DA, Palmen J, Redline S, Shields DC, Shuldiner AR, Sleiman PM, Smith GD, Farrall M, Jamshidi Y, Christiani DC, Casas JP, Hall AS, Doevendans PA, Christie JD, Berenson GS, Murray SS, Illig T, Dorn GW, Cappola TP, Boerwinkle E, Sever P, Rader DJ, Reilly MP, Caulfield M, Talmud PJ, Topol E, Engert JC, Wang K, Dominiczak A, Hamsten A, Curtis SP, Silverstein RL, Lange LA, Sabatine MS, Trip M, Saleheen D, Peden JF, Cruickshanks KJ, März W, O'Connell JR, Klungel OH, Wijmenga C, Maitland-van der Zee AH, Schadt EE, Johnson JA, Jarvik GP, Papanicolaou GJ, Hugh Watkins on behalf of PROCARDIS , Grant SF, Munroe PB, North KE, Samani NJ, Koenig W, Gaunt TR, Anand SS, van der Schouw YT, Meena Kumari on behalf of the Whitehall II Study and the WHII 50K Group , Soranzo N, Fitzgerald GA, Reiner A, Hegele RA, Hakonarson H, Keating BJ (2011). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.. Am J Hum Genet, 88(1), 6 - 18. doi:10.1016/j.ajhg.2010.11.007
    • Wensley F, Gao P, Burgess S, Kaptoge S, Di Angelantonio E, Shah T, Engert JC, Clarke R, Davey-Smith G, Nordestgaard BG, Saleheen D, Samani NJ, Sandhu M, Anand S, Pepys MB, Smeeth L, Whittaker J, Casas JP, Thompson SG, Hingorani AD, Danesh J, Eiriksdottir G, Harris TB, Launer LJ, Gudnason V, Folsom AR, Andrews G, Ballantyne CM, Samani NJ, Hall AS, Braund PS, Balmforth AJ, Whincup PH, Morris R, Lawlor DA, Lowe GDO, Timpson N, Ebrahim S, Ben-Shlomo Y, Davey-Smith G, Timpson N, Nordestgaard BG, Tybjaerg-Hansen A, Zacho J, Brown M, Sandhu M, Ricketts SL, Ashford S, Lange L, Reiner A, Cushman M, Tracy R, Wu C, Ge J, Zou Y, Sun A, Hung J, McQuillan B, Thompson P, Beilby J, Warrington N, Palmer LJ, Wanner C, Drechsler C, Hoffmann MM, Fowkes FGR, Lowe GDO, Tzoulaki I, Kumari M, Miller M, Marmot M, Onland-Moret C, van der Schouw YT, Boer JM, Wijmenga C, Ricketts L, Ashford S, Sandhu M, Khaw KT, Vasan RS, Schnabel RB, Yamamoto JF, Benjamin EJ, Schunkert H, Erdmann J, Konig IR, Hengstenberg C, Chiodini B, Franzosi MG, Pietri S, Gori F, Rudock M, Liu Y, Lohman K, Harris TB, Humphries SE, Hamsten A, Norman PE, Hankey GJ, Jamrozik K, Palmer LJ, Rimm EB, Pai JK, Psaty BM, Heckbert SR, Bis JC, Yusuf S, Anand S, Engert JC, Xie C, Collins R, Clarke R, Bennett D, Kooner J, Chambers J, Elliott P, Marz W, Kleber ME, Bohm BO, Winkelmann BR, Melander O, Berglund G, Koenig W, Thorand B, Baumert J, Peters A, Rimm EB, Manson J, Pai JK, Humphries SE, Cooper JA, Talmud PJ, Ladenvall P, Johansson L, Jansson JH, Hallmans G, Reilly MP, Qu L, Li M, Rader DJ, Watkins H, Clarke R, Hopewell J, Saleheen D, Danesh J, Frossard P, Sattar N, Robertson M, Shepherd J, Schaefer E, Hofman A, Witteman JCM, Kardys I, Dehghan A, de Faire U, Bennet A, Gigante B, Leander K, Ben-Shlomo Y, Davey-Smith G, Timpson N, Peters B, Maitland-van der Zee AH, de Boer A, Klungel O, Reiner A, Manson J, Greenland P, Dai J, Liu S, Kumari M, Brunner E, Kivimaki M, Marmot M, Sattar N, O'Reilly D, Ford I, Packard CJ, C Reactive Prot Coronary Heart Dis , AGES , ARIC , BHF-FHS , BRHS , BWHHS , CAPS , CCHS CGPS CIHDS , CHAOS , CHS , CRPHANS , CUDAS CUPID , 4D , EAS , ELSA , EPICNL , EPICNOR , FRAMOFF , GERMIFS , GISSI-P , HEALTHABC , HIFMECH , HIMS , HPFS , HVHS , INTERHEART , ISIS , LOLIPOP , LURIC , MALMO , MONICAKORA , NHS , NPHSII , NSC , PENNCATH , PROCARDIS , PROMIS , PROSPER , ROTTERDAM , SHEEP , SPEED , UCP , WHIOS , WHITEII , WOSCOPS (2011). Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. BRIT MED J, 342, - . doi:10.1136/bmj.d548
    • Zabaneh D, Kumari M, Sandhu M, Wareham N, Wainwright N, Papamarkou T, Hopewell J, Clarke R, Li K, Palmen J, Talmud PJ, Kronenberg F, Lamina C, Summerer M, Paulweber B, Price J, Fowkes G, Stewart M, Drenos F, Shah S, Shah T, Casas JP, Kivimaki M, Whittaker J, Hingorani AD, Humphries SE (2011). Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts.. Atherosclerosis, 217(2), 447 - 451. doi:10.1016/j.atherosclerosis.2011.04.015
    • Talmud PJ, Cooper JA, Gaunt T, Holmes MV, Shah S, Palmen J, Drenos F, Shah T, Kumari M, Kivimaki M, Whittaker J, Lawlor DA, Day IN, Hingorani AD, Casas JP, Humphries SE (2011). Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies.. Diabetologia, 54(7), 1710 - 1719. doi:10.1007/s00125-011-2108-6
    • Masi S, Salpea KD, Li K, Parkar M, Nibali L, Donos N, Patel K, Taddei S, Deanfield JE, D'Aiuto F, Humphries SE (2011). Oxidative stress, chronic inflammation, and telomere length in patients with periodontitis.. Free Radic Biol Med, 50(6), 730 - 735. doi:10.1016/j.freeradbiomed.2010.12.031
    • Harrison SC, Holmes MV, Agu O, Humphries SE (2011). Genome wide association studies of abdominal aortic aneurysms-biological insights and potential translation applications.. Atherosclerosis, 217(1), 47 - 56. doi:10.1016/j.atherosclerosis.2011.02.045
    • Jefferis BJMH, Papacosta O, Owen CG, Wannamethee SG, Humphries SE, Woodward M, Lennon LT, Thomson A, Welsh P, Rumley A, Lowe GDO, Whincup PH (2011). Interleukin 18 and coronary heart disease: Prospective study and systematic review (vol 217, pg 227, 2011). ATHEROSCLEROSIS, 219(2), 970 - 970. doi:10.1016/j.atherosclerosis.2011.08.010
    • Bown MJ, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, Gretarsdottir S, Badger SA, Bradley DT, Burnand K, Child AH, Clough RE, Cockerill G, Hafez H, Scott DJ, Futers S, Johnson A, Sohrabi S, Smith A, Thompson MM, van Bockxmeer FM, Waltham M, Matthiasson SE, Thorleifsson G, Thorsteinsdottir U, Blankensteijn JD, Teijink JA, Wijmenga C, de Graaf J, Kiemeney LA, Assimes TL, McPherson R, CARDIoGRAM Consortium , Global BPgen Consortium , DIAGRAM Consortium , VRCNZ Consortium , Folkersen L, Franco-Cereceda A, Palmen J, Smith AJ, Sylvius N, Wild JB, Refstrup M, Edkins S, Gwilliam R, Hunt SE, Potter S, Lindholt JS, Frikke-Schmidt R, Tybjærg-Hansen A, Hughes AE, Golledge J, Norman PE, van Rij A, Powell JT, Eriksson P, Stefansson K, Thompson JR, Humphries SE, Sayers RD, Deloukas P, Samani NJ (2011). Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.. Am J Hum Genet, 89(5), 619 - 627. doi:10.1016/j.ajhg.2011.10.002
    • Humphries SE (2011). Guidelines for the identification and management of patients with familial hypercholesterolaemia (FH): Are we coming to a consensus?. ATHEROSCLEROSIS SUPPLEMENTS, 12(2), 217 - 220. doi:10.1016/S1567-5688(11)00037-7
    • Skipworth JR, Szabadkai G, Olde Damink SW, Leung PS, Humphries SE, Montgomery HE (2011). Review article: pancreatic renin-angiotensin systems in health and disease.. Aliment Pharmacol Ther, 34(8), 840 - 852. doi:10.1111/j.1365-2036.2011.04810.x
    • Calabresi L, Baldassarre D, Simonelli S, Gomaraschi M, Amato M, Castelnuovo S, Frigerio B, Ravani A, Sansaro D, Kauhanen J, Rauramaa R, de Faire U, Hamsten A, Smit AJ, Mannarino E, Humphries SE, Giral P, Veglia F, Sirtori CR, Franceschini G, Tremoli E (2011). Plasma lecithin: cholesterol acyltransferase and carotid intima-media thickness in European individuals at high cardiovascular risk. J LIPID RES, 52(8), 1569 - 1574. doi:10.1194/jlr.P014977
    • Seed M, Roughton M, Nair D, Pederson K, Wang T, Neil AHW, Humphries SE (2011). CURRENT STATIN TREATMENT OF PATIENTS WITH FAMILIAL HYPERCHOLESTEROLAEMIA (FH): RESULTS FROM THE ROYAL COLLEGE OF PHYSICIANS UK NATIONAL AUDIT.
    • Humphries SE (2011). Editor in Chief's report for atherosclerosis for 2010.. Atherosclerosis, 214(1), 1 - 2. doi:10.1016/j.atherosclerosis.2010.12.003
    • Talmud PJ, Yiannakouris N, Humphries SE (2011). Lipoprotein association studies: taking stock and moving forward.. Curr Opin Lipidol, 22(2), 106 - 112. doi:10.1097/MOL.0b013e3283423f81
    • Smart MC, Dedoussis G, Yiannakouris N, Grisoni ML, Dror GK, Yannakoulia M, Papoutsakis C, Louizou E, Mantzoros CS, Melistas L, Kontogianni MD, Cooper JA, Humphries SE, Talmud PJ, EARSII Consortium (2011). Genetic variation within IL18 is associated with insulin levels, insulin resistance and postprandial measures.. Nutr Metab Cardiovasc Dis, 21(7), 476 - 484. doi:10.1016/j.numecd.2009.12.004
    • Jefferis BJ, Papacosta O, Owen CG, Wannamethee SG, Humphries SE, Woodward M, Lennon LT, Thomson A, Welsh P, Rumley A, Lowe GD, Whincup PH (2011). Interleukin 18 and coronary heart disease: prospective study and systematic review.. Atherosclerosis, 217(1), 227 - 233. doi:10.1016/j.atherosclerosis.2011.03.015
    • Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH, Aulchenko Y, Heath S, Sober S, Parsa A, Luan JA, Arora P, Dehghan A, Zhang F, Lucas G, Hicks AA, Jackson AU, Peden JF, Tanaka T, Wild SH, Rudan I, Igl W, Milaneschi Y, Parker AN, Fava C, Chambers JC, Fox ER, Kumari M, Go MJ, van der Harst P, Kao WHL, Sjogren M, Vinay DG, Alexander M, Tabara Y, Shaw-Hawkins S, Whincup PH, Liu YM, Shi G, Kuusisto J, Tayo B, Seielstad M, Sim X, Nguyen KDH, Lehtimaki T, Matullo G, Wu Y, Gaunt TR, Onland-Moret NC, Cooper MN, Platou CGP, Org E, Hardy R, Dahgam S, Palmen J, Vitart V, Braund PS, Kuznetsova T, Uiterwaal CSPM, Adeyemo A, Palmas W, Campbell H, Ludwig B, Tomaszewski M, Tzoulaki I, Palmer ND, Aspelund T, Garcia M, Chang YPC, O'Connell JR, Steinle NI, Grobbee DE, Arking DE, Kardia SL, Morrison AC, Hernandez D, Najjar S, McArdle WL, Hadley D, Brown MJ, Connell JM, Hingorani AD, Day INM, Lawlor DA, Beilby JP, Lawrence RW, Clarke R, Hopewell JC, Ongen H, Dreisbach AW, Li YL, Young JH, Bis JC, Kahonen M, Viikari J, Adair LS, Lee NR, Chen MH, Olden M, Pattaro C, Bolton JAH, Kottgen A, Bergmann S, Mooser V, Chaturvedi N, Frayling TM, Islam M, Jafar TH, Erdmann J, Kulkarni SR, Bornstein SR, Grassler J, Groop L, Voight BF, Kettunen J, Howard P, Taylor A, Guarrera S, Ricceri F, Emilsson V, Plump A, Barroso IS, Khaw KT, Weder AB, Hunt SC, Sun YV, Bergman RN, Collins FS, Bonnycastle LL, Scott LJ, Stringham HM, Peltonen L, Perola M, Vartiainen E, Brand SM, Staessen JA, Wang TJ, Burton PR, Artigas MS, Dong YB, Snieder H, Wang XL, Zhu HD, Lohman KK, Rudock ME, Heckbert SR, Smith NL, Wiggins KL, Doumatey A, Shriner D, Veldre G, Viigimaa M, Kinra S, Prabhakaran D, Tripathy V, Langefeld CD, Rosengren A, Thelle DS, Corsi AM, Singleton A, Forrester T, Hilton G, McKenzie CA, Salako T, Iwai N, Kita Y, Ogihara T, Ohkubo T, Okamura T, Ueshima H, Umemura S, Eyheramendy S, Meitinger T, Wichmann HE, Cho YS, Kim HL, Lee JY, Scott J, Sehmi JS, Zhang WH, Hedblad B, Nilsson P, Smith GD, Wong A, Narisu N, Stancakova A, Raffel LJ, Yao J, Kathiresan S, O'Donnell CJ, Schwartz SM, Ikram MA, Longstreth WT, Mosley TH, Seshadri S, Shrine NRG, Wain LV, Morken MA, Swift AJ, Laitinen J, Prokopenko I, Zitting P, Cooper JA, Humphries SE, Danesh J, Rasheed A, Goel A, Hamsten A, Watkins H, Bakker SJL, van Gilst WH, Janipalli CS, Mani KR, Yajnik CS, Hofman A, Mattace-Raso FUS, Oostra BA, Demirkan A, Isaacs A, Rivadeneira F, Lakatta EG, Orru M, Scuteri A, Ala-Korpela M, Kangas AJ, Lyytikainen LP, Soininen P, Tukiainen T, Wurtz P, Ong RTH, Dorr M, Kroemer HK, Volker U, Volzke H, Galan P, Hercberg S, Lathrop M, Zelenika D, Deloukas P, Mangino M, Spector TD, Zhai GJ, Meschia JF, Nalls MA, Sharma P, Terzic J, Kumar MVK, Denniff M, Zukowska-Szczechowska E, Wagenknecht LE, Fowkes FGR, Charchar FJ, Schwarz PEH, Hayward C, Guo XQ, Rotimi C, Bots ML, Brand E, Samani NJ, Polasek O, Talmud PJ, Nyberg F, Kuh D, Laan M, Hveem K, Palmer LJ, van der Schouw YT, Casas JP, Mohlke KL, Vineis P, Raitakari O, Ganesh SK, Wong TY, Tai ES, Cooper RS, Laakso M, Rao DC, Harris TB, Morris RW, Dominiczak AF, Kivimaki M, Marmot MG, Miki T, Saleheen D, Chandak GR, Coresh J, Navis G, Salomaa V, Han BG, Zhu XF, Kooner JS, Melander O, Ridker PM, Bandinelli S, Gyllensten UB, Wright AF, Wilson JF, Ferrucci L, Farrall M, Tuomilehto J, Pramstaller PP, Elosua R, Soranzo N, Sijbrands EJG, Altshuler D, Loos RJF, Shuldiner AR, Gieger C, Meneton P, Uitterlinden AG, Wareham NJ, Gudnason V, Rotter JI, Rettig R, Uda M, Strachan DP, Witteman JCM, Hartikainen AL, Beckmann JS, Boerwinkle E, Vasan RS, Boehnke M, Larson MG, Jarvelin MR, Psaty BM, Abecasis GR, Chakravarti A, Elliott P, van Duijn CM, Newton-Cheh C, Levy D, Caul (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. NATURE, 478(7367), 103 - 109. doi:10.1038/nature10405

    2010

    • Tremoli E, Nyyssonen K, Rauramaa R, de Faire U, Hamsten A, Smit AJ, Mannarino E, Humphries SE, Giral P, Grossi E, Veglia F, Paoletti R, Baldassarre D, IMPROVE Study Grp (2010). Interadventitia Common Carotid Artery Diameter Improves Carotid IMT Ability to Predict Coronary Events: Data from the IMPROVE Study: Carotid Intima Media Thickness (IMT) and IMT Progression as Predictors of Vascular Events in a High-Risk European Population.
    • Thompson AR, Cooper JA, Jones GT, Drenos F, van Bockxmeer FM, Biros E, Walker PJ, van Rij AM, Golledge J, Norman PE, Hafez H, Humphries SE (2010). Assessment of the association between genetic polymorphisms in transforming growth factor beta, and its binding protein (LTBP), and the presence, and expansion, of Abdominal Aortic Aneurysm.. Atherosclerosis, 209(2), 367 - 373. doi:10.1016/j.atherosclerosis.2009.09.073
    • Smart-Halajko MC, Robciuc MR, Cooper JA, Jauhiainen M, Kumari M, Kivimaki M, Khaw KT, Boekholdt SM, Wareham NJ, Gaunt TR, Day IN, Braund PS, Nelson CP, Hall AS, Samani NJ, Humphries SE, Ehnholm C, Talmud PJ (2010). The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk.. Arterioscler Thromb Vasc Biol, 30(11), 2277 - 2282. doi:10.1161/ATVBAHA.110.212209
    • Ken-Dror G, Drenos F, Humphries SE, Talmud PJ, Hingorani AD, Kivimäki M, Kumari M, Bauer KA, Morrissey JH, Ireland HA (2010). Haplotype and genotype effects of the F7 gene on circulating factor VII, coagulation activation markers and incident coronary heart disease in UK men.. J Thromb Haemost, 8(11), 2394 - 2403. doi:10.1111/j.1538-7836.2010.04035.x
    • Humphries SE, Neil HAW (2010). Developing and applying clinically useful approaches to identify individuals with familial hypercholesterolemia in the UK. CLIN LIPIDOL, 5(4), 497 - 507. doi:10.2217/CLP.10.39
    • Sofat R, Casas JP, Kumari M, Talmud PJ, Ireland H, Kivimaki M, Marmot M, Hughes AD, Thom S, Ebrahim S, Whittaker JC, Smeeth L, Lawlor DA, Humphries SE, Hingorani AD (2010). Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals.. Atherosclerosis, 213(1), 184 - 190. doi:10.1016/j.atherosclerosis.2010.07.021
    • Maubaret CG, Salpea KD, Jain A, Cooper JA, Hamsten A, Sanders J, Montgomery H, Neil A, Nair D, Humphries SE, HIFMECH Consortium , Simon Broome Res Grp (2010). TELOMERES ARE SHORTER IN PATIENTS WITH POLYGENIC AND MONOGENIC FORMS OF CORONARY HEART DISEASE.
    • Casas JP, Ninio E, Panayiotou A, Palmen J, Cooper JA, Ricketts SL, Sofat R, Nicolaides AN, Corsetti JP, Fowkes FG, Tzoulaki I, Kumari M, Brunner EJ, Kivimaki M, Marmot MG, Hoffmann MM, Winkler K, März W, Ye S, Stirnadel HA, Boekholdt SM, Khaw KT, Humphries SE, Sandhu MS, Hingorani AD, Talmud PJ (2010). PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry.. Circulation, 121(21), 2284 - 2293. doi:10.1161/CIRCULATIONAHA.109.923383
    • Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration , Sarwar N, Sandhu MS, Ricketts SL, Butterworth AS, Di Angelantonio E, Boekholdt SM, Ouwehand W, Watkins H, Samani NJ, Saleheen D, Lawlor D, Reilly MP, Hingorani AD, Talmud PJ, Danesh J (2010). Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.. Lancet, 375(9726), 1634 - 1639. doi:10.1016/S0140-6736(10)60545-4
    • Salpea KD, Humphries SE (2010). Telomere length in atherosclerosis and diabetes.. Atherosclerosis, 209(1), 35 - 38. doi:10.1016/j.atherosclerosis.2009.12.021
    • Sanderson SC, Waller J, Humphries S, Wardle J (2010). Public awareness of genetic influence on chronic disease risk: are genetic and lifestyle causal beliefs compatible?. Public Health Genomics, , - .
    • Sofat R, Hingorani AD, Smeeth L, Humphries SE, Talmud PJ, Cooper J, Shah T, Sandhu MS, Ricketts SL, Boekholdt SM, Wareham N, Khaw KT, Kumari M, Kivimaki M, Marmot M, Asselbergs FW, van der Harst P, Dullaart RP, Navis G, van Veldhuisen DJ, Van Gilst WH, Thompson JF, McCaskie P, Palmer LJ, Arca M, Quagliarini F, Gaudio C, Cambien F, Nicaud V, Poirer O, Gudnason V, Isaacs A, Witteman JC, van Duijn CM, Pencina M, Vasan RS, D'Agostino RB, Ordovas J, Li TY, Kakko S, Kauma H, Savolainen MJ, Kesaniemi YA, Sandhofer A, Paulweber B, Sorli JV, Goto A, Yokoyama S, Okumura K, Horne BD, Packard C, Freeman D, Ford I, Sattar N, McCormack V, Lawlor DA, Ebrahim S, Smith GD, Kastelein JJ, Deanfield J, Casas JP (2010). Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. Circulation, 121, 52 - 62.
    • Jones DA, Prior SL, Tang TS, Bain SC, Hurel SJ, Humphries SE, Stephens JW (2010). Association between the rs4880 superoxide dismutase 2 (C > T) gene variant and coronary heart disease in diabetes mellitus. DIABETES RES CLIN PR, 90(2), 196 - 201. doi:10.1016/j.diabres.2010.07.009
    • Mann JJ, Payne JR, Shah T, Pennell DJ, Humphries SE, Montgomery HE (2010). C-Reactive Protein Gene Variant and the Human Left Ventricular Growth Response to Exercise: Data From the LARGE Heart Study. J CARDIOVASC PHARM, 55(1), 26 - 29.
    • Taylor A, Bayly G, Patel K, Yarram L, Williams M, Hamilton-Shield J, Humphries SE, Norbury G (2010). A double heterozygote for familial hypercholesterolaemia and familial defective apolipoprotein B-100. ANN CLIN BIOCHEM, 47, 487 - 490. doi:10.1258/acb.2010.010089
    • Smith AJ, Palmen J, Putt W, Talmud PJ, Humphries SE, Drenos F (2010). Application of statistical and functional methodologies for the investigation of genetic determinants of coronary heart disease biomarkers: lipoprotein lipase genotype and plasma triglycerides as an exemplar.. Hum Mol Genet, 19(20), 3936 - 3947. doi:10.1093/hmg/ddq308
    • Thompson A, Cooper JA, Fabricius M, Humphries SE, Ashton HA, Hafez H (2010). An analysis of drug modulation of abdominal aortic aneurysm growth through 25 years of surveillance. J VASC SURG, 52(1), 55 - 61. doi:10.1016/j.jvs.2010.02.012
    • Guardiola M, Exeter HJ, Palmen J, Perret C, Li K, Cooper JA, Khaw KT, Sandhu MS, Ricketts S, Tedgui A, Humphries SE, Ninio E, Karabina SA, Boekhold SM, Mallat Z, Talmud PJ (2010). PLA2G2A, PLA2G5 AND PLA2G10 VARIANTS, SPLA2 ACTIVITY AND MASS AND CHD RISK: RESULTS FROM GRACE AND EPIC-NORFOLK.
    • Leigh S, Jakubcova T, Whittall RA, Humphries SE (2010). THE UCL LDLR, PCSK9 & LDLRAP1 VARIANT DATABASES: UPDATE, ANALYSIS & OVERVIEW OF THREE PUBLICLY AVAILABLE FAMILIAL HYPERCHOLESTEROLEMIA GENE DATABASES.
    • Humphries SE, Drenos F, Ken-Dror G, Talmud PJ (2010). Coronary heart disease risk prediction in the era of genome-wide association studies: current status and what the future holds.. Circulation, 121(20), 2235 - 2248. doi:10.1161/CIRCULATIONAHA.109.914192
    • Maubaret CG, Salpea KD, Jain A, Cooper JA, Hamsten A, Sanders J, Montgomery H, Neil A, Nair D, Humphries SE, HIFMECH consortium, Simon Broome Research Group (2010). Telomeres are shorter in myocardial infarction patients compared to healthy subjects: correlation with environmental risk factors.. J Mol Med (Berl), 88(8), 785 - 794. doi:10.1007/s00109-010-0624-3
    • Salpea KD, Talmud PJ, Cooper JA, Maubaret CG, Stephens JW, Abelak K, Humphries SE (2010). Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation.. Atherosclerosis, 209(1), 42 - 50. doi:10.1016/j.atherosclerosis.2009.09.070
    • Baldassarre D, Nyyssonen K, Rauramaa R, de Faire U, Hamsten A, Smit AJ, Mannarino E, Humphries SE, Giral P, Grossi E, Veglia F, Paoletti R, Tremoli E, IMPROVE Study Grp (2010). Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European population: the IMPROVE study. EUR HEART J, 31(5), 614 - 622. doi:10.1093/eurheartj/ehp496
    • Panayiotou AG, Nicolaides AN, Griffin M, Tyllis T, Georgiou N, Bond D, Martin RM, Hoppensteadt D, Fareed J, Humphries SE (2010). Leukocyte telomere length is associated with measures of subclinical atherosclerosis.. Atherosclerosis, 211(1), 176 - 181. doi:10.1016/j.atherosclerosis.2010.01.037
    • Smart MC, Dedoussis G, Louizou E, Yannakoulia M, Drenos F, Papoutsakis C, Maniatis N, Humphries SE, Talmud PJ (2010). APOE, CETP and LPL genes show strong association with lipid levels in Greek children.. Nutr Metab Cardiovasc Dis, 20(1), 26 - 33. doi:10.1016/j.numecd.2009.02.005
    • Whittall RA, Scartezini M, Li K, Hubbart C, Reiner Z, Abraha A, Neil HA, Dedoussis G, Humphries SE (2010). Development of a high-resolution melting method for mutation detection in familial hypercholesterolaemia patients.. Ann Clin Biochem, 47(Pt 1), 44 - 55. doi:10.1258/acb.2009.009076
    • Yiannakouris N, Cooper JA, Shah S, Ireland H, Stephens JW, Li KW, Elkeles R, Godsland I, Kivimaki M, Hingorani AD, Talmud PJ, Kumari M, Humphries SE (2010). Genetic variants near IRS1 and their association with type 2 diabetes, hyperinsulinemia and insulin resistance. DIABETES OBES METAB, 12, 46 - 46.

    2009

    • Humphries SE, Talmud PJ, Drenos F, Shah S, Palmen S, Shah T, Kumari M, Kivimaki M, Pallas J, Casas JP, Whittaker J, Hingorani A (2009). EXPLORING THE GENETIC ARCHITECTURE OF LIPID TRAITS IN WHITEHALL II HEALTHY MEN AND WOMEN USING THE 50K-SNP CARDIO-METABOLIC CHIP. doi:10.1016/j.atherosclerosis.2009.07.002
    • Salpea KD, Gable DR, Cooper JA, Stephens JW, Hurel SJ, Ireland HA, Feher MD, Godsland IF, Humphries SE (2009). The effect of WNT5B IVS3C>G on the susceptibility to type 2 diabetes in UK Caucasian subjects. Nutrition Metabolism and Cardiovascular Diseases, 19(2), 140 - 145.
    • Hingorani AD, Shah T, Casas JP, Humphries SE, Talmud PJ (2009). C-reactive protein and coronary heart disease: predictive test or therapeutic target?. Clin Chem, 55(2), 239 - 255. doi:10.1373/clinchem.2008.115923
    • Shah T, Casas JP, Cooper JA, Tzoulaki I, Sofat R, McCormack V, Smeeth L, Deanfield JE, Lowe GD, Rumley A, Fowkes FG, Humphries SE, Hingorani AD (2009). Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts.. Int J Epidemiol, 38(1), 217 - 231. doi:10.1093/ije/dyn217
    • Sanderson SC, Kumari M, Brunner E, Miller M, Lowe G, Rumley A, Marmot M, Humphries SE (2009). Association between IL6 gene variants -174G>C and -572G>C and plasma IL-6 levels in healthy adults: interactions with social position in the Whitehall II cohort.. Atherosclerosis, , - .
    • Salpea KD, Cooper JA, Talmud PJ, Humphries SE (2009). ANGPTL3 VARIATION IN TYPE 2 DIABETES. doi:10.1016/j.atherosclerosis.2009.09.065
    • Smart MC, Ehnholm C, Jauhiainen M, Robciuc M, Cooper JA, Drenos F, Humphries SE, Talmud PJ (2009). ANGPTL4 E40K AND T266M: EFFECTS ON PLASMA TRIGLYCERIDE AND HDL LEVELS, ANGPTL4 LEVELS AND CHD RISK. doi:10.1016/j.atherosclerosis.2009.09.044
    • Smart MC, Ehnholm C, Jauhiainen M, Robciuc M, Cooper JA, Drenos F, Humphries SE, Talmud PJ (2009). ASSOCIATION OF TELOMERE LENGTH WITH TYPE 2 DIABETES, OXIDATIVE STRESS AND UCP2 GENE VARIATION. doi:10.1016/j.atherosclerosis.2009.09.043
    • Smith AJ, Humphries SE (2009). Characterization of DNA-binding proteins using multiplexed competitor EMSA.. J Mol Biol, 385(3), 714 - 717. doi:10.1016/j.jmb.2008.11.035
    • Humphries SE, Neely RD, Whittall RA, Troutt JS, Konrad RJ, Scartezini M, Li KW, Cooper JA, Acharya J, Neil A (2009). Healthy individuals carrying the PCSK9 p.R46L variant and familial hypercholesterolemia patients carrying PCSK9 p.D374Y exhibit lower plasma concentrations of PCSK9.. Clin Chem, 55(12), 2153 - 2161. doi:10.1373/clinchem.2009.129759
    • Maubaret CG, Salpea KD, Jain A, Cooper JA, Sanders J, Montgomery H, Nair D, Humphries SE, HIFMECH Consortium (2009). TELOMERES ARE SHORTER IN MYOCARDIAL INFARCTION PATIENTS COMPARED TO HEALTHY SUBJECTS; CORRELATION WITH ENVIRONMENTAL AND GENETIC RISK FACTORS. doi:10.1136/hrt.2009.178137v
    • Maubaret CG, Heads R, Dhamrait S, Montgomery H, Humphries SE (2009). DOWN-REGULATION OF ACE EXPRESSION IN HUVECS USING siRNA RESULTS IN DOWN-REGULATION OF UCP2 EXPRESSION: A POTENTIAL MECHANISM OF THE CLINICAL BENEFIT OF ACE-INHIBITORS?. doi:10.1016/j.atherosclerosis.2009.09.055
    • Smith AJP, Drenos F, Palmen J, Putt W, Talmud PJ, Humphries SE (2009). FUNCTIONAL ANALYSIS OF REGULATORY LPL SNPS. doi:10.1016/j.atherosclerosis.2009.09.037
    • Panayiotou A, Georgiou N, Griffin M, Bond D, Tyllis T, Humphries SE, Nicolaides AN (2009). GENOTYPES AT MATRIX METALLOPROTINASE (MMP) LOCI FOR MMP7, MMP9 AND MMP12 ARE ASSOCIATED WITH CAROTID IMT AND PRESENCE OF PLAQUES. doi:10.1016/j.atherosclerosis.2009.09.057
    • Guardiola M, Ken-Dror G, Humphries SE, Talmud PJ (2009). LRP5 VARIANTS ARE ASSOCIATED WITH TRIGLYCERIDE LEVELS AND TYPE 2 DIABETES. doi:10.1016/j.atherosclerosis.2009.09.049
    • Humphries SE, Neely D, Whittall RA, Troutt J, Konrad RJ, Scartezini M, Li KW, Cooper JA, Acharya J, Neil HAW (2009). PLASMA PCSK9 LEVELS ARE LOW IN HEALTHY SUBJECTS CARRYING THE PCSK9 P.R46L VARIANT AND IN P.D374Y FAMILIAL HYPERCHOLESTEROL-EMIA PATIENTS. doi:10.1016/j.atherosclerosis.2009.07.005
    • Drenos F, Talmud PJ, Casas JP, Smeeth L, Palmen J, Humphries SE, Hingorani AD (2009). Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. HUM MOL GENET, 18(12), 2305 - 2316. doi:10.1093/hmg/ddp159
    • Prior SL, Gable DR, Cooper JA, Bain SC, Hurel SJ, Humphries SE, Stephens JW (2009). Association between the adiponectin promoter rs266729 gene variant and oxidative stress in patients with diabetes mellitus. EUR HEART J, 30(10), 1263 - 1269. doi:10.1093/eurheartj/ehp090
    • Sanders J, Hawe E, Brull DJ, Hubbart C, Lowe GD, Rumley A, Humphries SE, Montgomery HE (2009). Higher IL-6 levels but not IL6 -174G>C or -572G>C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery.. Atherosclerosis, 204(1), 196 - 201. doi:10.1016/j.atherosclerosis.2008.08.032
    • Thompson AR, Golledge J, Cooper JA, Hafez H, Norman PE, Humphries SE (2009). Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion.. Eur J Hum Genet, 17(3), 391 - 394. doi:10.1038/ejhg.2008.196
    • Smith AJ, Humphries SE (2009). Cytokine and cytokine receptor gene polymorphisms and their functionality.. Cytokine Growth Factor Rev, 20(1), 43 - 59. doi:10.1016/j.cytogfr.2008.11.006
    • Sanderson SC, Waller J, Jarvis MJ, Humphries SE, Wardle J (2009). Awareness of lifestyle risk factors for cancer and heart disease among adults in the UK. Patient Education and Counseling, 74, 221 - 227. doi:10.1016/j.pec.2008.08.003
    • Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. American Journal of Human Genetics, 85, 628 - 642.
    • Nibali L, D'Aiuto F, Donos N, Griffiths GS, Parkar M, Tonetti MS, Humphries SE, Brett PM (2009). Association between periodontitis and common variants in the promoter of the interleukin-6 gene.. Cytokine, 45(1), 50 - 54. doi:10.1016/j.cyto.2008.10.016
    • Hadfield SG, Horara S, Starr BJ, Yazdgerdi S, Marks D, Bhatnagar D, Cramb R, Egan S, Everdell R, Ferns G, Jones A, Marenah CB, Marples J, Prinsloo P, Sneyd A, Stewart MF, Sandle L, Wang T, Watson MS, Humphries SE, Steering Grp Dept Hlth Familial Hy (2009). Family tracing to identify patients with Familial Hypercholesterolaemia: the Second Audit of the Department of Health Familial Hypercholesterolaemia Cascade Testing Project. ANN CLIN BIOCHEM, 46, 24 - 32. doi:10.1258/acb.2008.008094
    • Ireland HA, Cooper JA, Drenos F, Acharya J, Mitchell JP, Bauer KA, Morrissey JH, Esnouf MP, Humphries SE (2009). FVII, FVIIa and downstream markers of extrinsic pathway activation differ by EPCR Ser219Gly variant in healthy men. ATVB, , - .
    • Shah S, Drenos F, Shah T, Palmen J, Vezzili C, Sofat R, Kumari M, Kivamaki M, Pallas J, MacFarlane P, Whittaker J, Talmud PJ, Humphries SE, Hingorani AD (2009). IDENTIFICATION OF GENES ASSOCIATED WITH QT INTERVAL USING THE 50K CARDIO-METABOLIC SNP CHIP: RESULTS FROM THE WHITEHALL II STUDY. doi:10.1016/j.atherosclerosis.2009.09.058

    2008

    • Talmud PJ, Smart M, Presswood E, Cooper JA, Drenos F, Nicaud V, Humphries SE (2008). ANGPTL4 VARIANTS ARE ASSOCIATED WITH LOWER PLASMA TRIGLYCERIDE LEVELS AND IMPROVED POSTPRANDIAL RESPONSES. ATHEROSCLEROSIS SUPP, 9(1), 7 - 7.
    • Muthumala A, Drenos F, Elliott PM, Humphries SE (2008). Role of beta adrenergic receptor polymorphisms in heart failure: Systematic review and meta-analysis. EUR J HEART FAIL, 10(1), 3 - 13. doi:10.1016/j.ejheart.2007.11.008
    • Leigh SE, Whittall RA, Hubbart CS, Humphries SE (2008). UPDATE AND ANALYSIS OF THE UCL LOW DENSITY LIPOPROTEIN RECEPTOR GENE (LDLR) FAMILIAL HYPERCHOLESTEROLEMIA (FH) DATABASE. ATHEROSCLEROSIS SUPP, 9(1), 107 - 108.
    • Humphries SE, Yiannakouris N, Talmud PJ (2008). Cardiovascular disease risk prediction using genetic information (gene scores): is it really informative?. Curr Opin Lipidol, 19(2), 128 - 132. doi:10.1097/MOL.0b013e3282f5283e
    • Thompson AR, Cooper JA, Ashton H, Druce S, Humphries SE, Hafez H (2008). The use of ACE inhibitors and angiotensin-II receptor antagonists is associated with a significant reduction in AAA growth rate, independent of arterial pressure.
    • Talmud PJ, Smart M, Presswood E, Cooper JA, Nicaud V, Drenos F, Palmen J, Marmot MG, Khaw KT, Kumari M, Humphries SEOBOTEARSIICATHIFMECHC (2008). ANGPTL4 E40K and T266M: effects on plasma Triglyceride and HDL levels, postprandial responses and CHD risk. Arteriosclerosis, Thrombosis, and Vascular Biology, , - .
    • Plunkett A, Agbeko R, Li K, Humphries SE, Klein NJ, Peters MJ (2008). Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children. Intensive Care Medicine, 34(12), 2279 - 2283.
    • Hosseini-Khalili AR, Thompson J, Kehoe A, Hopkinson NS, Khoshbaten A, Soroush MR, Humphries SE, Montgomery H, Ghanei M (2008). Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure.. BMC Pulm Med, 8, 15 - . doi:10.1186/1471-2466-8-15
    • Kivimaki M, Lawlor DA, Smith GD, Kumari M, Donald A, Britton A, Casas JP, Shah T, Brunner E, Timpson NJ, Halcox JP, Miller MA, Humphries SE, Deanfield J, Marmot MG, Hingorani AD (2008). Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study. , 3, e3013 - .
    • Samuel JM, Kelberman D, Smith AJP, Humphries SE, Woo P (2008). Identification of a novel region in the interleikin-6 gene promoter.. , 42(2), 256 - 264.
    • Brunner EJ, Kivimäki M, Witte DR, Lawlor DA, Smith GD, Cooper JA, Miller M, Lowe GD, Rumley A C, J P S, T H, S E H, A D M, M G T, N J K, M (2008). Inflammation, Insulin Resistance, and Diabetes -Mendelian Randomization Using CRP Haplotypes Points Upstream.. PLoS Medicine, 5(8), e155 - .
    • Sanderson SC, Humphries SE, Hubbart C, Hughes E, Jarvis MJ, Wardle J (2008). Psychological and behavioural impact of genetic testing smokers for lung cancer risk - A phase II exploratory trial. Journal of Health Psychology, 13(4), 481 - 494.
    • Miller GJ, Ireland HA, Cooper JA, Bauer KA, Morrissey JH, Humphries SE, Esnouf MP (2008). Relationship between markers of activated coagulation, their correlation with inflammation, and association with coronary heart disease (NPHSII). Journal of Thrombosis and Haemostasis, 6(2), 259 - 267.
    • Ozsait B, Komurcue-Bayrak E, Poda M, Can G, Hergenc G, Onat A, Humphries SE, Erginel-Unaltuna N (2008). CETP TaqIB polymorphism in Turkish adults: association with dyslipidemia and metabolic syndrome. ANADOLU KARDIYOL DER, 8(5), 324 - 330.
    • Dorfmeister B, Zeng WW, Dichlberger A, Nilsson SK, Schaap FG, Hubacek JA, Merkel M, Cooper JA, Lookene A, Putt W, Whittall R, Lee PJ, Lins L, Delsaux N, Nierman M, Kuivenhoven JA, Kastelein JJ, Vrablik M, Olivecrona G, Schneider WJ, Heeren J, Humphries SE, Talmud PJ (2008). Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.. Arterioscler Thromb Vasc Biol, 28(10), 1866 - 1871. doi:10.1161/ATVBAHA.108.172866
    • Elkeles RS, Godsland IF, Feher MD, Rubens MB, Roughton M, Nugara F, Humphries SE, Richmond W, Flather MD, PREDICT Study Grp (2008). Coronary calcium measurement improves prediction of cardiovascular events in asymptomatic patients with type 2 diabetes: the PREDICT study. EUR HEART J, 29(18), 2244 - 2251. doi:10.1093/eurheartj/ehn279
    • Wierzbicki AS, Humphries SE, Minhas R, Guideline Dev Grp (2008). Guidelines - Familial hypercholesterolaemia: summary of NICE guidance. BRIT MED J, 337(7668), - . doi:10.1136/bmj.a1095
    • Humphries SE, Norbury G, Leigh S, Hadfield SG, Nair D (2008). What is the clinical utility of DNA testing in patients with familial hypercholesterolaemia?. Curr Opin Lipidol, 19(4), 362 - 368. doi:10.1097/MOL.0b013e32830636e5
    • Humphries SE, Taylor A, Wang D, Whittall R, Neely D, Nair D, Barbir M, Egan S, Lolin Y, Hadfield G, Norbury G (2008). Mutation detection rate and spectrum in definite (DFH) and possible (PFH) patients from the department of health (DH) pilot project. doi:10.1016/j.atherosclerosis.2008.04.030
    • Salpea KD, Nicaud V, Tiret L, Talmud PJ, Humphries SE, EARS II group (2008). The association of telomere length with paternal history of premature myocardial infarction in the European Atherosclerosis Research Study II.. J Mol Med (Berl), 86(7), 815 - 824. doi:10.1007/s00109-008-0347-x
    • Palmen J, Smith AJ, Dorfmeister B, Putt W, Humphries SE, Talmud PJ (2008). The functional interaction on in vitro gene expression of APOA5 SNPs, defining haplotype APOA52, and their paradoxical association with plasma triglyceride but not plasma apoAV levels.. Biochim Biophys Acta, 1782(7-8), 447 - 452. doi:10.1016/j.bbadis.2008.03.003
    • Humphries SE (2008). Untitled. ATHEROSCLEROSIS, 199(1), 1 - 2. doi:10.1016/j.atherosclerosis.2008.02.018
    • Samuel JM, Kelberman D, Smith AJ, Humphries SE, Woo P (2008). Identification of a novel regulatory region in the interleukin-6 gene promoter.. Cytokine, 42(2), 256 - 264. doi:10.1016/j.cyto.2008.02.008
    • Leigh SE, Foster AH, Whittall RA, Hubbart CS, Humphries SE (2008). Update and analysis of the University College London low density lipoprotein receptor familial hypercholesterolemia database.. Ann Hum Genet, 72(Pt 4), 485 - 498. doi:10.1111/j.1469-1809.2008.00436.x
    • Humphries SE, Hadfield G (2008). Identifying patients with familial hypercholesterolaemia in primary care. HEART, 94(6), 695 - 696. doi:10.1136/hrt.2007.126292
    • Panayiotou A, Georgiou N, Nicolaides AN, Tyllis T, Griffin M, Bond D, Ninio E, Talmud PJ, Humphries SE (2008). ASSOCIATION OF LP-PLA2 ACTIVITY AND PAF-AH ALA379VAL GENOTYPE AND EARLY ATHEROSCLEROSIS. RESULTS FROM THE CYPRUS STUDY. ATHEROSCLEROSIS SUPP, 9(1), 112 - 112.
    • Smith AJ, D'Aiuto F, Palmen J, Cooper JA, Samuel J, Thompson S, Sanders J, Donos N, Nibali L, Brull D, Woo P, Humphries SE (2008). Association of serum interleukin-6 concentration with a functional IL6 -6331T>C polymorphism. Clin.Chem., 54(5), 841 - 850.
    • Verzilli C, Shah T, Casas JP, Chapman J, Sandhu M, Debenham SL, Boekholdt MS, Khaw KT, Wareham NJ, Judson R, Benjamin EJ, Kathiresan S, Larson MG, Rong J, Sofat R, Humphries SE, Smeeth L, Cavalleri G, Whittaker JC, Hingorani AD (2008). Bayesian meta-analysis of genetic association studies with different sets of markers. AM J HUM GENET, 82(4), 859 - 872. doi:10.1016/j.ajhg.2008.01.016
    • Humphries SE, Sofat R, Hingorani A, Smeeeth L, Talmud PJ, Cooper J, Shah T, Casas JP, CETP Collaborat Grp (2008). Use of Genetic Variation to Examine Mechanism-Based and Off-Target Actions of Pharmacological Agents : CETP SNPs, Torcetrapib, Lipids and Blood Pressure as an Example. J NUTRIGENET NUTRIGE, 1(6), 275 - 275.
    • Hadfield SG, Horara S, Starr BJ, Yazdgerdi S, Bhatnagar D, Cramb R, Egan S, Everdell R, Ferns G, Jones A, Marenah CB, Marples J, Prinsloo P, Sneyd A, Stewart MF, Sandle L, Wang T, Watson MS, Humphries SE (2008). Are patients with familial hypercholesterolaemia well managed in lipid clinics? An audit of eleven clinics from the Department of Health Familial Hypercholesterolaemia Cascade Testing project. ANN CLIN BIOCHEM, 45, 199 - 205. doi:10.1258/acb.2007.007078
    • Talmud PJ, Cooper JA, Palmen J, Lovering R, Drenos F, Hingorani AD, Humphries SE (2008). Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men.. Clin Chem, 54(3), 467 - 474. doi:10.1373/clinchem.2007.095489
    • Thompson AR, Cooper JA, Druce S, Ashton H, Hafez H, Humphries SE (2008). TGF3 and LTBP4 are associated with altered AAA growth: a candidate gene study. BRIT J SURG, 95(2), 265 - 266.
    • Smart M, Presswood E, Cooper JA, Drenos F, Palmen J, Humphries SE, Talmud PJ (2008). ANGPTL4 Variants are Associated with Lower Plasma Triglyceride Levels and Improved Postprandial Responses, but Increased CHD Risk, Independent of Triglycerides. J NUTRIGENET NUTRIGE, 1(1-2), 85 - 86.
    • Talmud PJ, Cooper JA, Humphries SE (2008). Gene: Environment Interaction on Coronary Heart Disease (CHD) Risk. J NUTRIGENET NUTRIGE, 1(1-2), 62 - 62.
    • Hopkinson NS, Li KW, Kehoe A, Humphries SE, Roughton M, Moxham J, Montgomery H, Polkey MI (2008). Vitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary disease. AM J CLIN NUTR, 87(2), 385 - 390.
    • Thompson AR, Drenos F, Hafez H, Humphries SE (2008). Candidate gene association studies in abdominal aortic aneurysm disease: a review and meta-analysis.. Eur J Vasc Endovasc Surg, 35(1), 19 - 30. doi:10.1016/j.ejvs.2007.07.022
    • Starr B, Hadfield SG, Hutten BA, Lansberg PJ, Leren TP, Damgaard D, Neil HAW, Humphries SE (2008). Development of sensitive and specific age- and gender-specific low-density lipoprotein cholesterol cutoffs for diagnosis of first-degree relatives with familial hypercholesterolaemia in cascade testing. CLIN CHEM LAB MED, 46(6), 791 - 803. doi:10.1515/CCLM.2008.135
    • Komurcu-Bayrak E, Onat A, Poda M, Humphries SE, Palmen J, Guclu F, Can G, Erginel-Unaltuna N (2008). Gender-modulated impact of apolipoprotein A5 gene (APOA5)-1131T > C and c.56C > G polymorphisms on lipids, dyslipidernia and metabolic syndrome in Turkish adults. CLIN CHEM LAB MED, 46(6), 778 - 784. doi:10.1515/CCLM.2008.161
    • Stephens JW, Dhamrait SS, Mani AR, Acharya J, Moore K, Hurel SJ, Humphries SE (2008). Interaction between the uncoupling protein 2 -866G > A gene variant and cigarette smoking to increase oxidative stress in subjects with diabetes. NUTR METAB CARDIOVAS, 18(1), 7 - 14. doi:10.1016/j.numecd.2007.01.010
    • Sanderson SC, Wardle J, Humphries SE (2008). Public Health Genomics and Genetic Test Evaluation: The Challenge of Conducting Behavioural Research on the Utility of Lifestyle-Genetic Tests. J NUTRIGENET NUTRIGE, 1(5), 224 - 231. doi:10.1159/000149826
    • Shah T, Casas JP, Cooper JA, Tzoulaki I, Sofat R, Smeeth L, Deanfield JE, Lowe GD, Rumley A, Fowkes FGR, Humphries SE, Hingorani AD (2008). CRITICAL APPRAISAL OF THE UTILITY OF CRP MEASUREMENT IN THE PREDICTION OF CARDIOVASCULAR EVENTS. ATHEROSCLEROSIS SUPP, 9(1), 10 - 10.

    2007

    • Shamaei-Tousi A, Steptoe A, O'Donnell K, Palmen J, Stephens JW, Hurel SJ, Marmot M, Homer K, D'Aiuto F, Coates ARM, Humphries SE, Henderson B (2007). Plasma heat shock protein 60 and cardiovascular disease risk: the role of psychosocial, genetic, and biological factors. Cell Stress and Chaperones, 12(4), 384 - 392.
    • Wootton PTE, Arora NL, Drenos F, Thompson SR, Cooper JA, Stephens JW, Hurel SJ, Hurt-Camejo E, Wiklund O, Humphries SE, Talmud PJ (2007). Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study. HUM MOL GENET, 16(12), 1437 - 1444. doi:10.1093/hmg/ddm094
    • Smith AJP, Cooper J, Palmen J, Saumel J, Thompson S, Woo P, Humphries SE (2007). Functional IL6 polymorphism is associated with IL-6 serum levels but not CVD.
    • Salpea KD, Gable DR, Cooper JA, Hurel SJ, Humphries SE (2007). The effect of the WNT5b IVS3C > G variation on the susceptibility to type 2 diabetes in UK caucasian subjects.
    • Drenos F, Miller GJ, Humphries SE (2007). Increase of plasma fibrinogen levels and variability with age in a sample of middle aged healthy men.. Ann Hum Genet, 71(Pt 1), 43 - 53. doi:10.1111/j.1469-1809.2006.00302.x
    • Dorfmeister B, Cooper JA, Stephens JW, Ireland H, Hurel SJ, Humphries SE, Talmud PJ (2007). The effect of APOA5 and APOC3 variants on lipid parameters in European Whites, Indian Asians and Afro-Caribbeans with type 2 diabetes. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1772(3), 355 - 363. doi:10.1016/j.bbadis.2006.11.008
    • Thompson SR, McCaskie PA, Beilby JP, Hung J, Jennens M, Chapman C, Thompson P, Humphries SE (2007). IL18 haplotypes are associated with serum IL-18 concentrations in a population-based study and a cohort of individuals with premature coronary heart disease.. Clin Chem, 53(12), 2078 - 2085. doi:10.1373/clinchem.2007.092692
    • Muthumala A, Gable DR, Palmen J, Cooper JA, Stephens JW, Miller GJ, Humphries SE (2007). Is the influence of variation in the ACE gene on the prospective risk of Type 2 diabetes in middle-aged men modified by obesity?. Clin Sci (Lond), 113(12), 467 - 472. doi:10.1042/CS20070158
    • Hadfield SG, Humphries SE (2007). Familial hypercholesterolaemia - Cascade testing is tried and tested and cost effective. BRIT MED J, 335(7622), 683 - 683.
    • Smith AJ, Ahmed F, Nair D, Whittall R, Wang D, Taylor A, Norbury G, Humphries SE (2007). A functional mutation in the LDLR promoter (-139C>G) in a patient with familial hypercholesterolemia.. Eur J Hum Genet, 15(11), 1186 - 1189. doi:10.1038/sj.ejhg.5201897
    • Smith AJ, Cooper JA, Li LK, Humphries SE (2007). INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects.. Int J Obes (Lond), 31(11), 1753 - 1755. doi:10.1038/sj.ijo.0803645
    • Hall R, Saukko PM, Evans PH, Qureshi N, Humphries SE (2007). Assessing family history of heart disease in primary care consultations: a qualitative study. FAM PRACT, 24(5), 435 - 442. doi:10.1093/fampra/cmm037
    • Thompson AR, Cooper JA, Humphries SE, Dasmohpatra M, Hafez H, Jones G, VanRij A (2007). Arterial wall remodelling and the ras. Implicated in AAA disease.
    • Erginel-Unaltuna N, Kormurcu-Bayrak E, Poda M, Becer E, Onat A, Humphries SE (2007). Endothelial nitric oxide synthase G894T gene poly morphism, blood pressure and hypertension in the Turkish adult risk factor study.
    • Komurcu-Bayrak E, Ozsait B, Poda M, Onat A, Can G, Humphries SE, Erginel-Unaltuna N (2007). Genes and HDL-C association in the adult Turkish population.
    • Descamps OS, Humphries SE (2007). How does the prevalence of family history of early cardiovascular disease compare in patients with and without familial hypercholesterolemia?.
    • Taylor A, Tabrah S, Wang D, Sozen M, Duxbury N, Whittall R, Humphries SE, Norbury G (2007). Multiplex ARMS analysis to detect 13 common mutations in familial hypercholesterolaemia. CLIN GENET, 71(6), 561 - 568. doi:10.1111/j.1399-004.2007.00807.x
    • Talmud PJ, Dorfmeister B, Cooper JA, Stephens JW, Ireland H, Humphries SE (2007). The effect of APOA5 and APOC3 variants on lipid parameters in European whites, Indian Asians and Afro-Caribbeans with type 2 diabetes.
    • Talmud PJ, Flavell DM, Alfakih K, Cooper JA, Balmforth AJ, Sivananthan M, Montgomery HE, Hall AS, Humphries SE (2007). The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart disease.. Clin Sci (Lond), 112(12), 617 - 624. doi:10.1042/CS20060344
    • Scartezini M, Whittall RA, Cooper JA, Humphries SE (2007). The R46L variant in the PCSK9 gene is associated with plasma lipid levels and lower cardiovascular risk in UK men.
    • Gable DR, Stephens JW, Dhamrait SS, Hawe E, Humphries SE, Himfech Study Grp (2007). European differences in the association between the UCP2-866G > A common gene variant and markers of body mass and fasting plasma insulin. DIABETES OBES METAB, 9(1), 130 - 131. doi:10.1111/j.1463-1326.2006.00573.x
    • Poda M, Komurcu-Bayrak E, Sansoy V, Onat A, Can G, Hergenc G, Humphries SE, Erginel-Unaltuna N (2007). The UCP3-55C/T polymorphism effects blood pressure levels in the Turkish adult risk factor (TARF) study.
    • Thompson SR, Novick D, Stock C, Rubinstein M, Woo P, Humphries SE, Sanders J (2007). Variation within IL18 but not IL18BP influences free IL-18 levels at baseline and during post-operative stress.
    • Hothi DK, Bass P, Morgan M, Acharya J, Humphries SE, Gilbert RD (2007). Acute renal failure in a patient with paroxysmal cold hemoglobinuria. PEDIATR NEPHROL, 22(4), 593 - 596. doi:10.1007/s00467-006-0352-7
    • Stephens JW, Hurel SJ, Lowe GDO, Rumley A, Humphries SE (2007). Association between plasma IL-6, the IL6-174G > C gene variant and the metabolic syndrome in type 2 diabetes mellitus. MOL GENET METAB, 90(4), 422 - 428. doi:10.1016/j.ymgme.2006.10.004
    • Harding DR, Humphries SE, Whitelaw A, Marlow N, Montgomery HE (2007). Cognitive outcome and cyclo-oxygenase-2 gene (-765 G/C) variation in the preterm infant. ARCH DIS CHILD-FETAL, 92(2), F108 - F112. doi:10.1136/adc.2006.099499
    • Tzoulaki I, Shah T, Ireland H, Casas JP, Hingorani AD, Humphries SE, Fowkes FGR (2007). C-reactive protein and interleukin-6 polymorphisms in relation to subclinical atherosclerotic disease.
    • Humphries SE, Cooper JA, Talmud PJ, Miller GJ (2007). Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men.. Clinical Chemistry, Jan; 53(1), 8 - 16.
    • Thompson SR, Novick D, Stock CJ, Sanders J, Brull D, Cooper J, Woo P, Miller G, Rubinstein M, Humphries SE (2007). Free Interleukin (IL)-18 levels, and the impact of IL18 and IL18BP genetic variation, in CHD patients and healthy men. Arterioscler Thromb Vasc Biol, 27(12), 2743 - 2749.
    • Gable D, Sanderson SC, Humphries SE (2007). Genotypes, obesity and type 2 diabetes - can genetic information motivate weight loss? A review. doi:10.1515/CCLM.2007.070
    • Wootton PT, Flavell DM, Montgomery HE, World M, Humphries SE, Talmud PJ (2007). Lipoprotein-associated phospholipase A2 A379V variant is associated with body composition changes in response to exercise training.. Nutr Metab Cardiovasc Dis, 17(1), 24 - 31. doi:10.1016/j.numecd.2005.11.008
    • Konstantoulas CJ, Cooper JA, Ohlin AK, Humphries SE, Goodall AH, Toh CH, Mather H, Ireland H (2007). Low soluble thrombomodulin activity and antigen is associated with a family history of heart disease while a high level is associated with a personal history of heart disease in type 2 diabetes.. Thrombosis and Haemostasis, 97(1), 161 - 164. doi:10.1160/TH06-03-0160
    • Payne JR, Dhamrait SS, Gohlke P, Cooper J, Scott RA, Pitsiladis YP, Humphries SE, Rayner B, Montgomery HE (2007). The impact of ACE genotype on serum ACE activity in a black South African male population.. Ann Hum Genet, 71(Pt 1), 1 - 7. doi:10.1111/j.1469-1809.2006.00300.x
    • Morange PE, Saut N, Alessi MC, Yudkin JS, Margaglione M, Di Minno G, Hamsten A, Humphries SE, Tregouet DA, Juhan-Vague I (2007). Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters - The HIFMECH study. ARTERIOSCL THROM VAS, 27(10), 2250 - 2257. doi:10.1161/ATVBAHA.107.149468
    • Whittall R, Jones G, Marshall K, Gijsbers E, Hubbart C, Humphries SE (2007). An in vitro assay for pre-mRNA splicing to test the functional impact of LDLR exonic and intronic sequence changes in patients with familial hypercholesterolaemia. doi:10.1016/j.atherosclerosis.2007.04.034
    • Hubbart C, Whittall R, Scartezini M, Humphries SE (2007). Development of an affordable, sensitive and rapid screening method for mutation detection in UKFH subjects. doi:10.1016/j.atherosclerosis.2007.04.032
    • Dorfmeister B, Heeren J, Merkel M, Talmud PJ, Humphries SE (2007). Amino acids 140-148 of APOAV play a crucial role in LPL activation.
    • Drenos F, Whittaker JC, Humphries SE (2007). The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk.. Ann Hum Genet, 71(Pt 5), 611 - 619. doi:10.1111/j.1469-1809.2007.00359.x
    • Leigh SEA, Whittall RA, Humphries SE (2007). Update and analysis of the UCL low density lipoprotein receptor gene familial hypercholesterolernia database. doi:10.1016/j.atherosclerosis.2007.04.036
    • Muthumala A, Montgomery H, Palmen J, Cooper JA, Humphries SE (2007). Angiotensin-converting enzyme genotype interacts with systolic blood pressure to determine coronary heart disease risk in healthy middle-aged men.. Hypertension, 50(2), 348 - 353. doi:10.1161/HYPERTENSIONAHA.107.086843
    • Payne JR, James LE, Eleftheriou KI, Hawe E, Mann J, Stronge A, Banham K, World M, Humphries SE, Pennell DJ, Montgomery HE (2007). The association of left ventricular mass with blood pressure, cigarette smoking and alcohol consumption; data from the LARGE heart study. INT J CARDIOL, 120(1), 52 - 58. doi:10.1016/j.ijcard.2006.08.043
    • Komurcu-Bayrak E, Onat A, Poda M, Humphries SE, Acharya J, Hergenc G, Coban N, Can G, Erginel-Unaltuna N (2007). The S447X variant of lipoprotein lipase gene is associated with metabolic syndrome and lipid levels among Turks. CLIN CHIM ACTA, 383(1-2), 110 - 115. doi:10.1016/j.cca.2007.05.007
    • Gable DR, Matin J, Whittall R, Cakmak H, Li KW, Cooper J, Miller GJ, Humphries SE, HIFMECH investigators (2007). Common adiponectin gene variants show different effects on risk of cardiovascular disease and type 2 diabetes in European subjects.. Ann Hum Genet, 71(Pt 4), 453 - 466. doi:10.1111/j.1469-1809.2006.00340.x
    • Scartezini M, Hubbart C, Whittall RA, Cooper JA, Neil AHW, Humphries SE (2007). The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy UK men. CLIN SCI, 113(11-12), 435 - 441. doi:10.1042/CS20070150

    2006

    • Thompson SR, Sanders J, Stephens JW, Lowe GD, Humphries SE (2006). An interleukin-18 (IL-18) haplotype is associated with higher BMI and inflammatory markers in subjects with diabetes and coronary heart disease.
    • Sanders J, Harris J, Cooper J, Gohlke P, Humphries SE, Montgomery HE, Woods DR (2006). Lack of change in serum angiotensin-converting enzyme activity during the menstrual cycle.. Journal of the Renin-Angiotensin-Aldosterone System, 7(4), 231 - 235.
    • Humphries SE, Hingorani A (2006). Pharmacogenetics: Progress, pitfalls and clinical potential for coronary heart disease.. Vascular Pharmacology, 44(2), 119 - 125.
    • Muthumala A, Cooper J, Humphries SE, HIFMECH Study Grp (2006). European differences in the association between ACE I/D polymorphism and incidence of MI may be explained by gene-lipid interaction. ATHEROSCLEROSIS, 189(2), 474 - 477. doi:10.1016/j.atherosclerosis.2006.05.008
    • Humphries SE, Whittall RA, Hubbart CS, Maplebeck S, Cooper JA, Soutar AK, Naoumova R, Thompson GR, Seed M, Durrington PN, Miller JP, Betteridge DJ, Neil HASBFHRGASSC (2006). Genetic causes of Familial Hypercholesterolaemia in UK patients: relation to plasma lipid levels and coronary heart disease risk.. Journal of Medical Genetics, 43(12), 943 - 949. doi:10.1136/jmg.2006.038356
    • Panayiotou A, Griffin M, Georgiou N, Bond D, Tyllis T, Humphries SE, Nicolaides AN (2006). Genotypes at the matrix metalloproteinase (MMP) loci for MMP9 and MMP12 are associated with carotid IMT measures of plaque stability.
    • Payne JR, Eleftheriou KI, James LE, Hawe E, Mann J, Stronge A, Kotwinski P, World M, Humphries SE, Pennell DJ, Montgomery HE (2006). Left ventricular growth response to exercise and cigarette smoking: data from LARGE Heart. HEART, 92(12), 1784 - 1788. doi:10.1136/hrt.2006.088294
    • Casas JP, Cavalleri GL, Bautista LE, Smeeth L, Humphries SE, Hingorani AD (2006). Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review.. Am J Epidemiol, 164(10), 921 - 935. doi:10.1093/aje/kwj302
    • Wootton PT, Stephens JW, Hurel SJ, Durand H, Cooper J, Ninio E, Humphries SE, Talmud PJ (2006). Lp-PLA2 activity and PLA2G7 A379V genotype in patients with diabetes mellitus.. Atherosclerosis, 189(1), 149 - 156. doi:10.1016/j.atherosclerosis.2005.12.009
    • Vieira JRS, Whittall RA, Cooper JA, Miller GJ, Humphries SE (2006). The A370T variant (Stul polymorphism) in the LDL receptor gene is not associated with plasma lipid levels or cardiovascular risk in UK men. ANN HUM GENET, 70, 697 - 704. doi:10.1111/j.1469-1809.2006.00294.x
    • Hindmarsh PC, Rodeck CH, Humphries SE (2006). Polymorphisms in the Angiotensin Converting Enzyme Gene and Growth in the First Year of Life. Ann.Hum.Genet., , - .
    • Gable DR, Hurel SJ, Humphries SE (2006). Adiponectin and its gene variants as risk factors for insulin resistance, the metabolic syndrome and cardiovascular disease.. Atherosclerosis, 188(2), 231 - 244. doi:10.1016/j.atherosclerosis.2006.02.010
    • Huth C, Heid IM, Vollmert C, Gieger C, Grallert H, Wolford JK, Langer B, Thorand B, Klopp N, Hamid YH, Pedersen O, Hansen T, Lyssenko V, Groop L, Meisinger C, Doring A, Lowel H, Lieb W, Hengstenberg C, Rathmann W, Martin S, Stephens JW, Ireland H, Mather H, Miller GJ, Stringham HM, Boehnke M, Tuomilehto J, Boeing H, Mohlig M, Spranger J, Pfeiffer A, Wernstedt I, Niklason A, Lopez-Bermejo A, Fernandez-Real JM, Hanson RL, Gallart L, Vendrell J, Tsiavou A, Hatziagelaki E, Humphries SE, Wichmann HE, Herder C, Illig T (2006). IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies. DIABETES, 55(10), 2915 - 2921. doi:10.2337/db06-0600
    • Talmud PJ, Cooper JA, Hattori H, Miller IP, Miller GJ, Humphries SE (2006). The apolipoprotein A-V genotype and plasma apolipoprotein A-V and triglyceride levels: prospective risk of type 2 diabetes. Results from the Northwick Park Heart Study II.. Diabetologia, 49(10), 2337 - 2340.
    • Barter PJ, Ballantyne CM, Carmena R, Castro Cabezas M, Chapman MJ, Couture P, de Graaf J, Durrington PN, Faergeman O, Frohlich J, Furberg CD, Gagne C, Haffner SM, Humphries SE, Jungner I, Krauss RM, Kwiterovich P, Marcovina S, Packard CJ, Pearson TA, Reddy KS, Rosenson R, Sarrafzadegan N, Sniderman AD, Stalenhoef AF, Stein E, Talmud PJ, Tonkin AM, Walldius G, Williams KM (2006). Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person/ten-country panel.. Journal of Internal Medicine, 259(3), 247 - 258.
    • Stephens JW, Dhamrait SS, Acharya J, Humphries SE, Hurel SJ (2006). A common variant in the ACE gene is associated with peripheral neuropathy in women with type 2 diabetes mellitus.. J Diabetes Complications, 20(5), 317 - 321. doi:10.1016/j.jdiacomp.2005.07.010
    • Vaessen SF, Schaap FG, Kuivenhoven JA, Groen AK, Hutten BA, Boekholdt SM, Hattori H, Sandhu MS, Bingham SA, Luben R, Palmen JA, Wareham NJ, Humphries SE, Kastelein JJ, Talmud PJ, Khaw KT (2006). Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study.. The Journal of Lipid Research, 47(9), 2064 - 2070.
    • Humphries SE, Starr B, Hadfield SG, Defesche J, Landsberg P, Ose L, Leren TP, Damgaard D, Neil HAW (2006). Development of sensitive and specific age- and gender-specific LDL-cholsterol cut-offs for diagnosis of relatives with FH in cascade testing.
    • Casas JP, Shah T, Cooper J, Hawe E, McMahon AD, Gaffney D, Packard CJ, O'Reilly DS, Juhan-Vague I, Yudkin JS, Tremoli E, Margaglione M, Di Minno G, Hamsten A, Kooistra T, Stephens JW, Hurel SJ, Livingstone S, Colhoun HM, Miller GJ, Bautista LE, Meade T, Sattar N, Humphries SE, Hingorani AD (2006). Insight into the nature of the CRP-coronary event association using Mendelian randomization.. Int J Epidemiol, 35(4), 922 - 931. doi:10.1093/ije/dyl041
    • Morgan L, Cooper J, Montgomery H, Kitchen N, Humphries SE (2006). The interleukin-6 gene –174G>C and –572G>C promoter polymorphisms are related to cerebral aneurysms. Journal of Neurology, Neurosurgery and Psychiatry, 77(8), 915 - 917. doi:10.1136/jnnp.2005.081976
    • Shamaei-Tousi A, Stephens JW, Bin R, Cooper JA, Steptoe A, Coates ARM, Henderson B, Humphries SE (2006). Association between plasma levels of heat shock protein 60 and cardiovascular disease in patients with diabetes mellitus. European Heart Journal, 27(13), 1565 - 1570. doi:10.1093/eurheartj/ehl081
    • Aitken WAE, Chisholm AWAH, Duncan AW, Harper MJ, Humphries SE, Mann JI, Skeaff CM, Sutherland WHF, Wallace AJ, Williams SM (2006). Variation in the cholesteryl ester transfer protein (CETP) gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat. NUTR METAB CARDIOVAS, 16(5), 353 - 363. doi:10.1016/j.numecd.2005.06.007
    • Konstantoulas CJ, Cooper J, Grizenkova J, Miller GJ, Humphries SE, Ireland H (2006). A variant in the thrombomodulin promoter leads to impaired expression in response to inflammatory cytokines; previous CHD-risk association explained.
    • Muthumala A, Cooper J, Humphries SE (2006). Ace iinsertion/deletion polymorphism interaction associated with regional incidence of myocardial infarction (MI) in Europe.
    • Humphries SE, Cooper JA, Talmud PJ, Miller GJ (2006). Can candidate gene genotypes improve estimation of CHD risk over-and above conventional risk factors in healthy UK men?.
    • Shah T, Cooper JA, Casas JP, Pearce K, Tinworth L, Hingorani AD, Miller GJ, Humphries SE (2006). CRP in the prediction and pathogenesis of cardiovascular events in middle-aged men; Results from the NPHSII study.
    • Gable DR, Stephens JW, Cooper JA, Miller G, Humphries SE (2006). The association of UCP2-866G > A with prospective risk of type 2 diabetes is due to reduced insulin secretion from the pancreas.
    • Dorfmeister B, Zeng WW, Schaap F, Nierman M, Kuivenhoven JA, Kastelein J, Hubacek JA, Vrablik M, Humphries SE, Talmud PJ (2006). Two novel APOA5 missense mutations in patients with severe hypertriglyceridemia.
    • Stephens JW, Gable DR, Hurel SJ, Miller GJ, Cooper JA, Humphries SE (2006). Increased plasma markers of oxidative stress are associated with coronary heart disease in males with diabetes mellitus and with 10-year risk in a prospective sample of males.. Clinical Chemistry, 52(3), 446 - 452. doi:10.1373/clinchem.2005.060194
    • Casas JP, Cooper J, Miller GJ, Hingorani AD, Humphries SE (2006). Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studies. , 70, 145 - 169.
    • Humphries SE, Cranston T, Allen M, Middleton-Price H, Fernandez MC, Senior V, Hawe E, Iversen A, Wray R, Crook MA, Wierzbicki AS (2006). Mutational analysis in UK patients with a clinical diagnosis of familial hypercholesterolaemia: relationship with plasma lipid traits, heart disease risk and utility in relative tracing.. J Mol Med (Berl), 84(3), 203 - 214. doi:10.1007/s00109-005-0019-z
    • Hayek T, Stephens JW, Hubbart CS, Acharya J, Caslake MJ, Hawe E, Miller GJ, Hurel SJ, Humphries SE (2006). A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitus.. Atherosclerosis, 184(2), 404 - 412.
    • Shearman AM, Cooper JA, Kotwinski PJ, Humphries SE, Mendelsohn ME, Housman DE, Miller GJ (2006). Estrogen receptor alpha gene variation is associated with risk of stroke in the Second Northwick Park Heart Study.
    • Flavell DM, Wootton PT, Myerson SG, World MJ, Pennell DJ, Humphries SE, Talmud PJ, Montgomery HE (2006). Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth.. Journal of Molecular Medicine, 84(2), 126 - 131.
    • Wootton PT, Drenos F, Cooper JA, Thompson SR, Stephens JW, Hurt-Camejo E, Wiklund O, Humphries SE, Talmud PJ (2006). Tagging-SNP haplotype analysis of the secretory PLA2IIa gene PLA2G2A shows strong association with serum levels of sPLA2IIa: results from the UDACS study.. Human Molecular Genetics, 15(2), 355 - 361.
    • Marks D, Thorogood M, Neil SM, Humphries SE, Neil HAW (2006). Cascade screening for familial hypercholesterolaemia: implications of a pilot study for national screening programmes. J MED SCREEN, 13(3), 156 - 159.
    • Humphries SE, Gable D, Cooper JA, Ireland H, Stephens JW, Hurel S, Li KW, Palmen J, Miller MA, Cappuccio FP, Elkeles R, Godsland I, Miller GJ, Talmud PJ (2006). Common variants in the TCF7L2 gene and predisposition to Type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women.. Journal of Molecular Medicine, 84(12), 1005 - 1014.
    • Wong WM, Gerry AB, Putt W, Roberts JL, Weinberg RB, Humphries SE, Leake DS, Talmud PJ (2006). Common variants of apolipoprotein A-IV differ in their ability to inhibit low density lipoprotein oxidation.. Atherosclerosis, , - .
    • Shearman AM, Cooper JA, Kotwinski PJ, Miller GJ, Humphries SE, Ardlie KG, Jordan B, Irenze K, Lunetta KL, Schuit SCE, Uitterlinden AG, Pols HAP, Demissie S, Cupples LA, Mendelsohn ME, Levy D, Housman DE (2006). Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts. Circulation Research, 98(5), 590 - 592.
    • Gable DR, Stephens JW, Cooper JA, Miller GJ, Humphries SE (2006). Variation in the UCP2-UCP3 gene cluster predicts the development of type 2 diabetes in healthy middle-aged men.. Diabetes, 55(5), 1504 - 1511. doi:10.2337/db05-1645

    2005

    • Talmud PJ, Stephens JW, Hawe E, Demissie S, Cupples LA, Hurel SJ, Humphries SE, Ordovas JM (2005). The significant increase in cardiovascular disease risk in APOEepsilon4 carriers is evident only in men who smoke: potential relationship between reduced antioxidant status and ApoE4.. Ann Hum Genet, 69(Pt 6), 613 - 622. doi:10.1111/j.1529-8817.2005.00205.x
    • Reiner AP, Diehr P, Browner WS, Humphries SE, Jenny NS, Cushman M, Tracy RP, Walston J, Lumley T, Newman AB, Kuller LH, Psaty BM (2005). Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: The cardiovascular health study.. Atherosclerosis, 181(1), 175 - 183.
    • Bashiardes E, Bhonagiri V, Bashiardes S, Pantzaris M, Angelides N, Cariolou MA, Nicolaides AN, Humphries SE, Lovett M (2005). Gene expression in atherosclerotic plaques categorised by their echodensity.
    • Morgan L, Humphries SE (2005). The genetics of stroke.. Current Opinion in Lipidology, 16(2), 193 - 199.
    • Flavell D, Ireland HA, Stephens J, Hawe E, Acharya J, Mather H, Hurel S, Humphries S (2005). Peroxisome Proliferator-activated receptor alpha gene variation influences age of onset and progression of type 2 diabetes. Diabetes, 54(2), 582 - 586. doi:10.2337/diabetes.54.2.582
    • Tabrah S, Tabrah S, Taylor A, Humphries SE, Norbury G (2005). A strategy for molecular genetic mutation screening for familial hypercholesterolaemia. Journal of Medical Genetics, 42, S110 - S110.
    • Zhao JH, Brunner EJ, Kumari M, Singh-Manoux A, Hawe E, Talmud PJ, Marmot MG, Humphries SE (2005). APOE polymorphism, socioeconomic status and cognitive function in late mid-life: the Whitehall II study. Social Psychiatry and Psychiatric Epidemiology, 40, 557 - 563.
    • Zhao JH, Brunner EJ, Kumari M, Singh-Manoux A, Hawe E, Talmud PJ, Marmot MG, Humphries SE (2005). APOE polymorphism, socioeconomic status and cognitive function in mid-life The Whitehall II longitudinal study.. Social Psychiatry and Psychiatric Epidemiology, 40(7), 557 - 563.
    • D'Aiuto F, Casas JP, Shah T, Humphries SE, Hingorani AD, Tonetti MS (2005). C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulus.. Atherosclerosis, 179(2), 413 - 417. doi:10.1016/j.atherosclerosis.2004.10.036
    • Li P, Sanders J, Hawe E, Brull D, Montgomery H, Humphries S (2005). Inflammatory response to coronary artery bypass surgery: does the heme-oxygenase-1 gene microsatellite polymorphism play a role?. Chinese Medical Journal (English Edition), 118(15), 1285 - 1290.
    • Palmen J, Colhoun HM, Van Tol A, Hattori H, Humphries SE (2005). A novel common variant -181 G insertion in the promoter of the gene for phospholipid transfer protein.. Atherosclerosis, 180(1), 211 - 213.
    • Cooper JA, Miller GJ, Humphries SE (2005). A comparison of the PROCAM and Framingham point-scoring systems for estimation of individual risk of coronary heart disease in the Second Northwick Park Heart Study.. Atherosclerosis, 181(1), 93 - 100.
    • Shearman AM, Cooper JA, Kotwinski PJ, Humphries SE, Mendelsohn ME, Housman DE, Miller GJ (2005). Estrogen receptor alpha gene variation and the risk of stroke.. Stroke, 36(10), 2281 - 2282.
    • Li P, Elrayess MA, Gomma AH, Palmen J, Hawe E, Fox KM, Humphries SE (2005). The microsatellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting.. Chinese Medical Journal (English Edition), 118(18), 1525 - 1532.
    • Talmud P, Palmen J, Putt W, Lins L, Humphries SE (2005). Determination of the functionality of common APOA5 polmorphisms. Journal of Biological Chemistry, 280(31), 28215 - 28220. doi:10.1074/jbc.M502144200
    • Hadfield SG, Humphries SE (2005). Implementation of cascade testing for the detection of familial hypercholesterolaemia.. Current Opinion in Lipidology, 16(4), 428 - 433.
    • Morgan L, Hawe E, Palmen J, Montgomery H, Humphries SE, Kitchen N (2005). Polymorphism of the heme oxygenase-1 gene and cerebral aneurysms.. British Journal of Neurosurgery, 19(4), 317 - 321.
    • Alharbi KK, Aldahmesh MA, Spanakis E, Haddad L, Whittall RA, Chen XH, Rassoulian H, Smith MJ, Sillibourne J, Ball NJ, Graham NJ, Briggs PJ, Simpson IA, Phillips DI, Lawlor DA, Ye S, Humphries SE, Cooper C, Smith GD, Ebrahim S, Eccles DM, Day IN (2005). Mutation scanning by meltMADGE: validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare, and paucimorphic mutations in the general population.. Genome Research, 15(7), 967 - 977.
    • Ireland H, Konstantoulas CJ, Humphries SE, Ohlin AK, Mather H, Goodall AH, Hogwood J, Stearns-Kurosawa DJ, Kurosawa S, Esmon CT (2005). Novel genetic predisposition to coronary heart disease associated with the protein C pathway.
    • Payne JR, World M, Humphries SE, Pennell DJ, Montgomery HE (2005). The effect of smoking and other lifestyle factors on the left ventricular growth response to exercise in 312 young healthy men assessed using cardiovascular magnetic resonance.
    • Harding D, Brull D, Humphries SE, Whitelaw A, Montgomery H, Marlow N (2005). Variation in the interleukin-6 gene is associated with impaired cognitive development in children born prematurely: A preliminary study. , , 117 - 120.
    • Waterworth DM, Jansen H, Nicaud V, Humphries SE, Talmud PJOBOTEARSIIS, g ROUP (2005). Interaction between insulin (VNTR) and hepatic lipase (LIPC-514C>T) variants on the response to an oral glucose tolerance test in the EARSII group of young healthy men.. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1740(3), 375 - 381.
    • Fife MS, Ogilvie EM, Kelberman D, Samuel J, Gutierrez A, Humphries SE, Woo P (2005). Novel IL-6 haplotypes and disease association. Genes Immun, 6(4), 367 - 370.
    • Younis J, Cooper JA, Miller GJ, Humphries SE, Talmud PJ (2005). Genetic variation in alcohol dehydrogenase 1C and the beneficial effect of alcohol intake on coronary heart disease risk in the Second Northwick Park Heart Study.. Atherosclerosis, 180(2), 225 - 232.
    • Sozen MM, Whittall R, Oner C, Tokatli AE, Kalkanoglu HS, Dursun A, Coskun T, Oner R, Humphries SE (2005). The molecular basis of familial hypercholesterolaemia in Turkish patients. ATHEROSCLEROSIS, 180(1), 63 - 71. doi:10.1016/j.athersclerosis.2004.12.042
    • Sozen MM, Whittall R, Oner C, Tokatli A, Kalkanoglu HS, Dursun A, Coskun T, Oner R, Humphries SE (2005). The molecular basis of familial hypercholesterolaemia in Turkish patients.. Atherosclerosis, 180(1), 63 - 71.
    • Newson AJ, Humphries SE (2005). Cascade testing in familial hypercholesterolaemia: how should family members be contacted?. European Journal of Human Genetics, 13(4), 401 - 408.
    • Morange PE, Saut N, Alessi MC, Frere C, Hawe E, Yudkin JS, Tremoli E, Margaglione M, Di Minno G, Hamsten A, Humphries SE, Juhan-Vague I HIFMECH Study GROUP (2005). Interaction between the C-260T polymorphism of the CD14 gene and the plasma IL-6 concentration on the risk of myocardial infarction: the HIFMECH study.. Atherosclerosis, 179(2), 317 - 323.
    • Neil HA, Hawkins MM, Durrington PN, Betteridge DJ, Capps NE, Humphries SESBFHRGASS, C OMMITTEE (2005). Non-coronary heart disease mortality and risk of fatal cancer in patients with treated heterozygous familial hypercholesterolaemia: a prospective registry study.. Atherosclerosis, 179(2), 293 - 297.
    • Humphries SE (2005). Pharmacogenetics: Progress, pitfalls and clinical potential.
    • Talmud PJ, Palmen J, Putt W, Humphries SE (2005). Resolution of the functionality of APOA5 common variants.
    • Harding DR, Dhamrait S, Devadason D, Humphries SE, Whitelaw A, Marlow N, Montgomery HE (2005). Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth?. J NEUROINFLAMMATION, 2(1), 6 - .
    • Eriksson-Berg M, Deguchi H, Hawe E, Scanavini D, Orth-Gomer K, Schenck-Gustafsson K, Humphries SE, Silveira A, Hamsten A (2005). Influence of factor VII gene polymorphisms and environmental factors on plasma coagulation factor VII concentrations in middle-aged women with and without manifest coronary heart disease.. Thrombosis and Haemostasis, 93(2), 351 - 358.
    • Boekholdt SM, Sacks FM, Jukema JW, Shepherd J, Freeman DJ, McMahon AD, Cambien F, Nicaud V, de Grooth GJ, Talmud PJ, Humphries SE, Miller GJ, Eiriksdottir G, Gudnason V, Kauma H, Kakko S, Savolainen MJ, Arca M, Montali A, Liu S, Lanz HJ, Zwinderman AH, Kuivenhoven JA, Kastelein JJ (2005). Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects.. Circulation, 111(3), 278 - 287.
    • Ireland H, Konstantoulas CJ, Cooper JA, Hawe E, Humphries SE, Mather HG, A H H, J Juhan-Vague I, Yudkin JS, Di Minno G, Margaglione M, Hamsten A, Miller GJ, Bauer KAK, Y T Stearns-Kurosawa DJ, Kurosawa S (2005). EPCR Ser219Gly: elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitro. Atherosclerosis, 183, 283 - 292.
    • Hunter A, Humphries SE (2005). Family history of breast cancer and cost of life assurance: a test case comparison of current UK industry practice. BMJ (Clinical Research Ed.), 331(7530), 1438 - 1439.
    • Gable DR, Stephens JW, Humphries SE, Hurel SJ (2005). The +276G > T adiponectin gene SNP is associated with cardiovascular disease in patients with type 2 diabetes mellitus.
    • Stephens JW, Dhamrait SS, Cooper JA, Acharya J, Miller GJ, Hurel SJ, Humphries SE (2005). The D allele of the ACE I/D common gene variant is associated with Type 2 diabetes mellitus in Caucasian subjects.. Mol Genet Metab, 84(1), 83 - 89. doi:10.1016/j.ymgme.2004.09.002
    • Stephens JW, Sozen MM, Whittall RA, Caslake MJ, Bedford D, Acharya J, Hurel SJ, Humphries SE (2005). Three novel mutations in the apolipoprotein E gene in a sample of individuals with type 2 diabetes mellitus. CLIN CHEM, 51(1), 119 - 124. doi:10.1373/j.clinchem.2004.040121
    • Stephens JW, Sozen MM, Whittall RA, Caslake MJ, Bedford D, Acharya J, Hurel SJ, Humphries SE (2005). Three novel mutations in the apolipoprotein E gene in a sample of individuals with type 2 diabetes mellitus.. Clinical Chemistry, 51(1), 119 - 124.

    2004

    • Stephens JW, Ambler G, Vallance P, Betteridge DJ, Humphries SE, Hurel SJ (2004). Cardiovascular risk and diabetes. Are the methods of risk prediction satisfactory?. Eur J Cardiovasc Prev Rehabil, 11(6), 521 - 528.
    • Payne J, Dhamrait SS, Cooper J, Jones A, Miller GJ, Humphries SE, Montgomery HE (2004). The -344T>C promoter variant of the gene for aldosterone synthase (CYP11B2) is not associated with cardiovascular risk in a prospective study of UK healthy men. Atherosclerosis, 174(1), 81 - 86.
    • Miller GJ, Bauer KA, Howarth DJ, Cooper JA, Humphries SE, Rosenberg RD (2004). Increased incidence of neoplasia of the digestive tract in men with persistent activation of the coagulant pathway.. Journal of Thrombosis and Haemostasis, 2(12), 2107 - 2114.
    • Miller GJ, Bauer KA, Howarth DJ, Cooper JA, Humphries SE, Rosenberg RD (2004). Increased incidence of neoplasia with persistent activation of the of the digestive tract in men coagulant pathway. J THROMB HAEMOST, 2(12), 2107 - 2114.
    • Mannila MN, Silveira A, Hawe E, Eriksson P, Aillaud MF, Juhan-Vague I, Yudkin J, Margaglione M, di Minno G, Mussoni L, Tremoli E, Humphries S, Hamsten A The HIFMECH Study GROUP (2004). Plasma fibrinogen concentration predicts the risk of myocardial infarction differently in various parts of Europe: effects of beta-fibrinogen genotype and environmental factors. The HIFMECH Study.. Thrombosis and Haemostasis, 92(6), 1240 - 1249.
    • Foucher C, Rattier S, Flavell DM, Talmud PJ, Humphries SE, Kastelein JJ, Ayyobi A, Pimstone S, Frohlich J, Ansquer JC, Steiner G DAIS INVESTIGATORS (2004). Response to micronized fenofibrate treatment is associated with the peroxisome-proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetes.. Pharmacogenetics, 14(12), 823 - 829.
    • Konstantoulas CJ, Cooper J, Warnock G, Miller GJ, Humphries SE, Ireland H (2004). A combination of two common thrombomodulin gene variants (-1208-1209TTdelTT and A455V) influence risk of coronary heart disease: a prospective study in men.. Atherosclerosis, 177(1), 97 - 104.
    • Kelberman D, Fife M, Rockman MV, Brull DJ, Woo P, Humphries SE (2004). Analysis of common IL-6 promoter SNP variants and the AnTn tract in humans and primates and effects on plasma IL-6 levels following coronary artery bypass graft surgery. Biochim Biophys Acta, 1688(2), 160 - 167.
    • Kelberman D, Hawe E, Luong LA, Mohamed-Ali V, Lundman P, Tornvall P, Aillaud MF, Juhan-Vague I, Yudkin JS, Margaglione M, di Minno G, Tremoli E, Humphries SE, HIFMECH study grp (2004). Effect of interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe. THROMB HAEMOSTASIS, 92(5), 1122 - 1128. doi:10.1160/TH04-04-0202
    • Kelberman D, Hawe E, Luong LA, Mohamed-Ali V, Lundman P, Tornvall P, Aillaud MF, Juhan-Vague I, Yudkin JS, Margaglione M, di Minno G, Tremoli E, Humphries SE, HIFMECH study group (2004). Effect of Interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe. The HIFMECH Study.. Thromb Haemost, 92(5), 1122 - 1128. doi:10.1267/THRO04051122
    • Elrayess MA, Webb KE, Bellingan GJ, Whittall RA, Kabir J, Hawe E, Syvanne M, Taskinen MR, Frick MH, Nieminen MS, Kesaniemi YA, Pasternack A, Miller GJ, Humphries SE (2004). R643G polymorphism in PECAM-1 influences transendothelial migration of monocytes and is associated with progression of CHD and CHD events.. Atherosclerosis, 177(1), 127 - 135.
    • Ireland H, Miller GJ, Webb KE, Cooper JA, Humphries SE (2004). The factor VII activating protease G511E (Marburg) variant and cardiovascular risk.. Thromb Haemost, 92(5), 986 - 992. doi:10.1267/THRO04050986
    • Sanders J, Hawe E, Brull DJ, Hubbart C, Lowe GD, Rumley A, Humphries SE, Montgomery HE (2004). Higher IL-6 levels but not IL-6-174G > C or-572G > C genotype are associated with postoperative complication following coronary artery bypass surgery (CABG).
    • Austin MA, Hutter CM, Zimmern RL, Humphries SE (2004). Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review.. American Journal of Epidemiology, 160(5), 407 - 420.
    • Sanderson SC, Wardle J, Jarvis MJ, Humphries SE (2004). Public interest in genetic testing for susceptibility to heart disease and cancer: a population-based survey in the UK. Preventive Medicine, 39(3), 458 - 464.
    • Sanderson SC, Wardle J, Jarvis MJ, Humphries SE (2004). Public interest in genetic testing for susceptibility to heart diseaseand cancer: a population-based survey in the UK. Preventive Medicine, 39(3), 458 - 464.
    • Wong WMR, Stephens JW, Acharya J, Hurel SJ, Humphries SE, Talmud PJ (2004). The APOA4 T347S variant is associated with reduced plasma TAOS in subjects with diabetes mellitus and cardiovascular disease. J LIPID RES, 45(8), 1565 - 1571. doi:10.1194/jlr.M400130
    • Wong WM, Stephens JW, Acharya J, Hurel SJ, Humphries SE, Talmud PJ (2004). The APOA4 T347S variant is associated with reduced plasma TAOS in subjects with diabetes mellitus and cardiovascular disease.. The Journal of Lipid Research, 45(8), 1565 - 1571.
    • Putt W, Palmen J, Nicaud V, Tregouet DA, Tahri-Daizadeh N, Flavell DM, Humphries SE, Talmud PJ, EARSII GROUP (2004). Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II.. Human Molecular Genetics, 13(15), 1587 - 1597. doi:10.1093/hmg/ddh168
    • Marteau T, Senior V, Humphries SE, Bobrow M, Cranston T, Crook MA, Day L, Fernandez M, Horne R, Iversen A, Jackson Z, Lynas J, Middleton-Price H, Savine R, Sikorski J, Watson M, Weinman J, Wierzbicki AS, Wray R (2004). Psychological impact of genetic testing for familial hypercholesterolemia within a previously aware population: a randomized controlled trial.. American Journal of Medical Genetics. Part A, 128A(3), 285 - 293. doi:10.1002/ajmg.a.30102
    • Yudkin JS, Juhan-Vague I, Hawe E, Humphries SE, di Minno G, Margaglione M, Tremoli E, Kooistra T, Morange PE, Lundman P, Mohamed-Ali V, Hamsten A The HIFMECH Study GROUP (2004). Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH study.. Metabolism, 53(7), 852 - 857.
    • Austin MA, Zhang C, Humphries SE, Chandler WL, Talmud PJ, Edwards KL, Leonetti DL, McNeely MJ, Fujimoto WY (2004). Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans.. Annals of Human Genetics, 68(3), 179 - 188.
    • Humphries SE, Morgan L (2004). Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches.. The Lancet Neurology, 3(4), 227 - 235.
    • Humphries SE, Ridker PM, Talmud PJ (2004). Genetic testing for cardiovascular disease susceptibility: a useful clinical management tool or possible misinformation?. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(4), 628 - 636.
    • Rodriguez S, Gaunt TR, O'Dell SD, Chen XH, Gu D, Hawe E, Miller GJ, Humphries SE, Day IN (2004). Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits.. Human Molecular Genetics, 13(7), 715 - 725.
    • Austin MA, Edwards KL, McNeely MJ, Chandler WL, Leonetti DL, Talmud PJ, Humphries SE, Fujimoto WY (2004). Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese americans.. Diabetes, 53(4), 1166 - 1169.
    • Theobald HE, Chowienczyk PJ, Whittall R, Humphries SE, Sanders TA (2004). LDL cholesterol-raising effect of low-dose docosahexaenoic acid in middle-aged men and women.. American Journal of Clinical Nutrition, 79(4), 558 - 563.
    • Williams AG, Dhamrait S, Wootton PT, Day SH, Hawe E, Payne JR, Myerson SG, World M, Budgett R, Humphries SE, Montgomery HE (2004). A bradykinin receptor gene variant and human physical performance. Journal of Applied Physiology, 96, 938 - 942.
    • Talmud PJ, Lewis SJ, Hawe E, Martin S, Acharya J, Marmot MG, Humphries SE, Brunner EJ (2004). No APOE epsilon 4 effect on coronary heart disease risk in a cohort with low smoking prevalence: the Whitehall II study. ATHEROSCLEROSIS, 177(1), 105 - 112. doi:10.1016/j.athersclerosis.2004.06.008
    • Harding DR, Dhamrait S, Whitelaw A, Humphries SE, Marlow N, Montgomery HE (2004). Does interleukin-6 genotype influence cerebral injury or developmental progress after preterm birth?. , , 941 - 947.
    • Casas JP, Hingorani AD, Humphries SE, Smeeth L, Bautista LE (2004). Do meta-analyses of association studies of endothelial nitric oxide synthase variants and ischemic heart disease provide conclusive answers? Response. CIRCULATION, 110(11), E305 - E306.
    • Harding D, Montgomery HE, Humphries SE, Marlow N, Whitelaw A (2004). Does common variation in the Cylcooxygenase-2 gene affect neurocognitive outcome after premature birth?.
    • Stephens JW, Hurel SJ, Cooper JA, Acharya J, Miller GJ, Humphries SE (2004). A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus.. Molecular Genetics and Metabolism, 82(2), 180 - 186.
    • Naoumova RP, Neuwirth C, Pottinger B, Whittal R, Humphries SE, Soutar AK (2004). Genetic diagnosis of familial hypercholesterolaemia: a mutation and a rare non-pathogenic amino acid variant in the same family.. Atherosclerosis, 174(1), 67 - 71.
    • Talmud PJ, Martin S, Taskinen MR, Frick MH, Nieminen MS, Kesaniemi YA, Pasternack A, Humphries SE, Syvanne M (2004). APOA5 gene variants, lipoprotein particle distribution, and progression of coronary heart disease: results from the LOCAT study.. The Journal of Lipid Research, 45(4), 750 - 756.
    • Sanders TA, de Grassi T, Acharya J, Miller GJ, Humphries SE (2004). Postprandial variations in fibrinolytic activity in middle-aged men are modulated by plasminogen activator inhibitor I 4G-675/5G genotype but not by the fat content of a meal.. American Journal of Clinical Nutrition, 79(4), 577 - 581.
    • Casas JP, Bautista LE, Humphries SE, Hingorani AD (2004). Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects.. Circulation, 109(11), 1359 - 1365. doi:10.1161/01.CIR.0000121357.76910.A3
    • Alharbi KK, Haddad L, Ye S, Lawlor DA, Whittall RA, Spanakis E, Chen X, Rassoulian H, Simpson I, Phillips DIW, Cooper C, Smith GD, Humphries SE, Ebrahim S, Day INM (2004). Mutation scanning of LDLR in the whole population.
    • Stephens JW, Hurel SJ, Acharya J, Humphries SE (2004). An interaction between the interleukin-6 -174G>C gene variant and urinary protein excretion influences plasma oxidative stress in subjects with type 2 diabetes.. Cardiovascular Diabetology, 3(1), 2 - .
    • Konstantoulas C, Hawe E, Saut N, Yudkin JS, di Minno G, Margaglione M, Hamsten A, Humphries SE, Juhan-Vague I, Ireland H, HIFMECH SGROUP (2004). Common variants in the thrombomodulin gene as a risk for myocardial infarction in the north of Europe (HIFMECH Study).. Thrombosis and Haemostasis, 91(3), 628 - 630. doi:10.1267/THRO04030628
    • Neil HA, Hammond T, Mant D, Humphries SE (2004). Effect of statin treatment for familial hypercholesterolaemia on life assurance: results of consecutive surveys in 1990 and 2002.. BMJ (Clinical Research Ed.), 328(7438), 500 - 501.
    • Hendriksz CJ, Norbury G, Tabrah S, Taylor A, Humphries SE (2004). Homozygous hypercholesterolaemia and ezetimibe: a case report.. Acta Paediatrica, 93(2), 280 - 282.
    • Syvanne M, Whittall RA, Turpeinen U, Nieminen MS, Frick MH, Kesaniemi YA, Pasternack A, Humphries SE, Taskinen MR (2004). Serum homocysteine concentrations, gemfibrozil treatment, and progression of coronary atherosclerosis.. Atherosclerosis, 172(2), 267 - 272.
    • Talmud PJ, Lewis SJ, Hawe E, Martin S, Acharya J, Marmot MG, Humphries SE, Brunner EJ (2004). No APOE epsilon 4 effect on coronary heart disease risk in a cohort with low smoking prevalence: the Whitehall II study. Atherosclerosis, 177, 105 - 112.
    • Tsianos G, Sanders J, Dhamrait S, Humphries S, Grant S, Montgomery H (2004). The ACE gene insertion/deletion polymorphism and elite endurance swimming. European Journal of Applied Physiology, 92(3), 360 - 362. doi:10.1007/s00421-004-1120-7
    • Ireland H, Miller G, Webb K, Cooper J, Humphries SE (2004). The Factor VII activating protease G511E (Marburg) variant and cardiovascular risk.. Thrombosis and Haemostasis, 92(5), 986 - 992. doi:10.1160/TH04-05-0275
    • Woods D, Sanders J, Jones A, Hawe E, Gohlke P, Humphries SE, Payne J, Montgomery H (2004). The serum angiotensin-converting enzyme and angiotensin II response to altered posture and acute exercise, and the influence of ACE genotype.. European Journal of Applied Physiology, 91(2-3), 342 - 348. doi:10.1007/s00421-003-0993-1
    • Stephens JW, Humphries SE, Cooper J, Hurel SJ (2004). What are the clinical manifestations of cardiovascular disease in diabetes? Ten year analysis from a clinic based population. The British Journal of Diabetes and Vascular Disease, 4, 190 - 194.
    • Austin MA, Talmud PJ, Farin FM, Nickerson DA, Edwards KL, Leonetti D, McNeely MJ, Viernes HM, Humphries SE, Fujimoto WY (2004). Association of apolipoprotein A5 variants with LDL particle size and triglyceride in Japanese Americans.. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1688(1), 1 - 9.
    • Talmud PJ, Hawe E, Miller GJ, Humphries SE (2004). Are plasma triglycerides a good predictor of CHD risk.. International Congress Series, 1262, 207 - 210.
    • Williams AG, Dhamrait SS, Wootton PT, Day SH, Hawe E, Payne JR, Myerson SG, World M, Budgett R, Humphries SE, Montgomery HE (2004). Bradykinin receptor gene variant and human physical performance.. Journal of Applied Physiology, 96(3), 938 - 942. doi:10.1152/japplphysiol.00865.2003
    • Dhamrait SS, Stephens JW, Cooper JA, Acharya J, Mani AR, Moore K, Miller GJ, Humphries SE, Hurel SJ, Montgomerty HE (2004). Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2.. European Heart Journal, 25, 468 - 475.
    • Marks D, Thorogood M, Farrer JM, Humphries SE (2004). Census of clinics providing specialist lipid services in the United Kingdom. Journal of Public Health, 26(4), 353 - 354.
    • Neil HAW, Hammond T, Humphries SE (2004). Effect of statin treatment for familial hypercholesterolaemia on life assurance: results of consecutive surveys in 1990 and 2002. BMJ (Clinical Research Ed.), 328, 163 - 183.
    • Chen XH, Rodriguez S, Hawe E, Talmud PJ, Miller GJ, Underhill P, Humphries SE, Day INM (2004). Evidence of admixture from haplotyping in an epidemiological study of UK Caucasian males: Implications for association analyses. HUM HERED, 57(3), 142 - 155. doi:10.1159/000079245
    • Austin M, Hutter C, Zimmern R, Humphries SE (2004). Familial hypercholesterolemia and coronary heart disease: a HuGE association review. American Journal of Epidemiology, 160, 421 - 429.
    • Hutter C, Austin M, Humphries SE (2004). Familial hypercholesterolemia, peripheral arterial disease and stroke: a HuGE mini-review. American Journal of Epidemiology, 160, 430 - 435.
    • Talmud PJ, Humphries SE (2004). Gene: environment interactions and coronary heart disease risk.. World Review of Nutrition and Dietetics, 93, 29 - 40.
    • Austin M, Hutter C, Zimmern R, Humphries SE (2004). Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review. American Journal of Epidemiology, 160, 421 - 429.
    • Humphries SE, Morgan L (2004). Genetic risk factors for stroke: insights into patho-physiology from candidate gene approaches. International Congress Series, 1262, 482 - 485.
    • Sozen M, Whittal R, Humphries SE (2004). Mutation detection in patients with familial hypercholesterolaemia using heteroduplex and single strand conformation polymorphism analysis by capillary electrophoresis. Atherosclerosis, S5, 7 - 11.
    • James L, Onambele G, Woledge R, Skelton D, Woods D, Eleftheriou K, Hawe E, Humphries SE, Haddad F, Montgomery H (2004). IL-6-174G/C Genotype is Associated With the Bone Mineral Density Response to Oestrogen Replacement Therapy in Post-Menopausal Women. European Journal of Applied Physiology, 92(1-2), 227 - 230. doi:10.1007/s00421-004-1092-7
    • Sanderson SC, Wardle J, Jarvis M, Humphries SE (2004). Public interest in genetic testing for susceptibility to heart disease: a population-based survey in the UK. Preventive Medicine, 3, 458 - 464.
    • Neil HA, Seagroatt V, Betteridge DJ, Cooper MP, Durrington PN, Miller JP, Seed M, Naoumova RP, Thompson GR, Huxley R, Humphries SE (2004). Established and emerging coronary risk factors in patients with heterozygous familial hypercholesterolaemia.. Heart, 90(12), 1431 - 1437.

    2003

    • Chapman CM, Beilby JP, Humphries SE, Palmer LJ, Thompson PL, Hung J (2003). Association of an allelic variant of interleukin-6 with subclinical carotid atherosclerosis in an Australian community population. European Heart Journal, 24(16), 1494 - 1499.
    • Dhamrait SS, Payne JR, Li P, Jones A, Toor IS, Cooper JA, Hawe E, Palmen JM, Wootton PT, Miller GJ, Humphries SE, Montgomery HE (2003). Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension. European Heart Journal, 24(18), 1672 - 1680.
    • Abuzeid AM, Hawe E, Humphries SE, Talmud PJ (2003). Association between the Ala379Val variant of the lipoprotein associated phospholipase A2 and risk of myocardial infarction in the north and south of Europe. Atherosclerosis, 168(2), 283 - 288.
    • Panahloo A, Mohamed-Ali V, Gray RP, Humphries SE, Yudkin JS (2003). Plasminogen activator inhibitor-1 (PAI-1) activity post myocardial infarction: the role of acute phase reactants, insulin-like molecules and promoter (4G/5G) polymorphism in the PAI-1 gene. Atherosclerosis, 168(2), 297 - 304.
    • Hubacek JA, Pitha J, Skodova Z, Poledne R, Lanska V, Waterworth DM, Humphries SE, Talmud PJ (2003). Polymorphisms in CYP-7A1, not APOE, influence the change in plasma lipids in response to population dietary change in an 8 year follow-up; results from the Czech MONICA study. Clinical Biochemistry, 36(4), 263 - 267.
    • Montgomery H, Humphries SE, Leung PS (2003). Renin-angiotensin systems: the new frontier. INT J BIOCHEM CELL B, 35(6), 758 - 758. doi:10.1016/S1357-2725(03)00003-7
    • Webb KE, Martin JF, Cotton J, Erusalimsky JD, Humphries SE (2003). The 4830C>A polymorphism within intron 5 affects the pattern of alternative splicing occurring within exon 6 of the thrombopoietin gene. Experimental Hematology, 31(6), 488 - 494.
    • Humphries SE, Hawe E, Dhamrait S, Miller GJ, Talmud PJ (2003). In search of genetic precision. The Lancet, 361(9372), 1908 - 1909.
    • Dhamrait SS, Payne JR, Li P, Jones A, Toor IS, Cooper J, Hawe E, Palmen J, Wootton P, Miller G, Humphries SE, Montgomery HE (2003). Variation in the human kinin receptor genes increases hypertensive cardiovascular risk.
    • Wong WM, Hawe E, Li LK, Miller GJ, Nicaud V, Pennacchio LA, Humphries SE, Talmud PJ (2003). Apolipoprotein AIV gene variant S347 is associated with increased risk of coronary heart disease and lower plasma apolipoprotein AIV levels. Circulation Research, 92(9), 969 - 975. doi:10.1161/01.RES.0000069688.94567.7A
    • Elrayess MA, Webb KE, Flavell DM, Syvanne M, Taskinen MR, Frick MH, Nieminen MS, Kesaniemi YA, Pasternack A, Jukema JW, Kastelein JJ, Zwinderman AH, Humphries SE (2003). A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies. Atherosclerosis, 168(1), 131 - 138.
    • Friedlander Y, Kark JD, Sinnreich R, Basso F, Humphries SE (2003). Combined segregation and linkage analysis of fibrinogen variability in Israeli families: evidence for two quantitative-trait loci, one of which is linked to a functional variant (-58G > A) in the promoter of the alpha-fibrinogen gene. Annals of Human Genetics, 67(Pt 3), 228 - 241.
    • Dhamrait SS, Payne JR, Li P, Jones A, Toor IS, Cooper JA, Hawe E, Palmen J, Wootton P, Miller G, Humphries SE, Montgomery HE (2003). Variation in the bradykinin receptor B1 and B2 genes alters the cardiovascular risk associated with hypertension.
    • Martin S, Nicaud V, Humphries SE, Talmud PJ (2003). Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1637(3), 217 - 225. doi:10.1016/S0925-4439(03)00033-4
    • Waterworth DM, Talmud PJ, Luan J, Flavell DM, Byrne CD, Humphries SE, Wareham NJ (2003). Variants in the APOC3 promoter insulin responsive element modulate insulin secretion and lipids in middle-aged men. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1637(3), 200 - 206. doi:10.1016/S0925-4439(03)00021-8
    • Stephens JW, Palmen JM, Hurel SJ, Humphries SE (2003). A long-range PCR method for genotyping promoter variants in the interleukin-6 gene. Thrombosis and Haemostasis, 89(4), 765 - 767.
    • Harding D, Dhamrait S, Humphries SE, Montgomery H, Whitelaw A, Marlow N (2003). Is interleukin-6 genotype associated with outcome after preterm birth?.
    • Harding D, Dhamrait S, Marlow N, Whitelaw A, Gupta S, Humphries S, Montgomery H (2003). IL-6 -572 genotype and outcome after premature birth. Pediatrics, 112(114), 800 - 803.
    • Talmud PJ, Martin S, Steiner G, Flavell DM, Whitehouse DB, Nagl S, Jackson R, Taskinen MR, Frick MH, Nieminen MS, Kesaniemi YA, Pasternack A, Humphries SE, Syvanne M (2003). Progression of atherosclerosis is associated with variation in the alpha1-antitrypsin gene. Arteriosclerosis, Thrombosis, and Vascular Biology, 23(4), 644 - 649.
    • Marks D, Thorogood M, Neil HA, Wonderling D, Humphries SE (2003). Comparing costs and benefits over a 10 year period of strategies for familial hypercholesterolaemia screening. Journal of Public Health Medicine, 25(1), 47 - 52.
    • Dhamrait SS, James L, Brull DJ, Myerson S, Hawe E, Pennell DJ, World M, Humphries SE, Haddad F, Montgomery HE (2003). Cortical Bone Resorption During Exercise is Interleukin-6 Genotype-Dependent. European Journal of Applied Physiology, 89(1), 21 - 25.
    • Hawe E, Talmud PJ, Miller GJ, Humphries SE (2003). Family history is a coronary heart disease risk factor in the Second Northwick Park Heart Study. Annals of Human Genetics, 67(Pt 2), 97 - 106.
    • Camilleri RS, MacKie IJ, Humphries SE, MacHin SJ, Cohen H (2003). Lack of association of beta2-glycoprotein I polymorphisms Val247Leu and Trp316Ser with antiphospholipid antibodies in patients with thrombosis and pregnancy complications. British Journal of Haematology, 120(6), 1066 - 1072.
    • Cotton JM, Hong Y, Hawe E, Mathur A, Humphries SE, Brown AS, Martin JF, Erusalimsky JD (2003). Rise of circulating thrombopoietin following cardiothoracic surgery is potentiated in patients with coronary atherosclerosis: correlation with a preceding increase in levels of interleukin-6. Thrombosis and Haemostasis, 89(3), 538 - 543.
    • Fisher RM, Benhizia F, Schreiber R, Makoveichuk E, Putt W, Al Haideri M, Deckelbaum RJ, Olivecrona G, Humphries SE, Talmud PJ (2003). Enhanced bridging function and augmented monocyte adhesion by lipoprotein lipase N9: insights into increased risk of coronary artery disease in N9 carriers. Atherosclerosis, 166(2), 243 - 251.
    • Stephens JW, Humphries SE (2003). The molecular genetics of cardiovascular disease: clinical implications. Journal of Internal Medicine, 253(2), 120 - 127.
    • Harding D, Dhamrait S, Millar A, Humphries S, Marlow N, Whitelaw A, Montgomery H (2003). Is interleukin-6-174 genotype associated with the development of septicemia in preterm infants?. , , 800 - 803.
    • Panahloo A, Mohamed-Ali V, Gray RP, Humphries SE, Yudkin JS (2003). PAI-1 activity post myocardial infarction: the role of acute phase reactants, insulin-like molecules and promoter (4G/5G) polymorphism in the PAI-1 gene.. Atherosclerosis, 168, 297 - 304.
    • Huxley RR, Hawkins MH, Humphries SE, Karpe F, Neil HA (2003). Risk of fatal stroke in patients with treated familial hypercholesterolemia: a prospective registry study. Stroke, 34(1), 22 - 25.
    • Jones A, Sanders J, Hurret S, Goldstone J, Gohlke R, Humphries S, Montgomery H (2003). The angiotensin II response to an acute exercise stimulus and the angiotensin converting enzyme genotype.
    • Ferrari SL, Ahn-Luong L, Garnero P, Humphries SE, Greenspan SL (2003). Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women. Journal of Clinical Endocrinology and Metabolism, 88(1), 255 - 259.
    • Talmud PJ, Hawe E, Miller GJ, Humphries SE (2003). Genetic determinants of plasma triglycerides and CHD risk.
    • Humphries SE (2003). Genetic risk factors for stroke: Insights into patho-physiology from candidate gene approaches.
    • Marks D, Thorogood M, Neil HA, Humphries SE (2003). A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia. Atherosclerosis, 168(1), 1 - 14.
    • Harding D, Dhamrait S, Marlow N, Whitelaw A, Gupta S, Humphries S, Montgomery H (2003). Angiotensin Converting Enzyme (ACE) DD genotype is associated with worse perinatal cardio-respiratory adaptation in preterm infants. The Journal of Pediatrics, 143(6), 746 - 749.
    • Hopkinson I, Humphries SE (2003). Family History of Coronary Heart Disease.
    • Harding D, Dhamrait S, Marlow N, Whitelaw A, Gupta S, Humphries S, Montgomery H (2003). Angiotensin-converting enzyme DD genotype is associated with worse perinatal cardiorespiratory adaptation in preterm infants. , , 746 - 749.
    • Robertson KS, Hawe E, Miller GJ, Talmud PJ, Humphries SE (2003). Human paraoxonase gene cluster polymorphisms as predictors of coronary heart disease risk in the prospective Northwick Park Heart Study II. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1639(3), 203 - 212. doi:10.1016/j.bbadis.2003.09.008
    • Stygall J, Newman SP, Fitzgerald G, Steed L, Mulligan K, Arrowsmith JE, Pugsley W, Humphries S, Harrison MJ (2003). Cognitive change 5 years after coronary artery bypass surgery. Health Psychology, 22(6), 579 - 586. doi:10.1037/0278-6133.22.6.579
    • Dedoussis GV, Pitsavos C, Kelberman D, Skoumas J, Prassa ME, Choumerianou DM, Stefanadis C, Humphries SE, Toutouzas P (2003). FH-Pyrgos: a novel mutation in the promoter (-45delT) of the low-density lipoprotein receptor gene associated with familial hypercholesterolemia. Clinical Genetics, 64(5), 414 - 419.
    • Brull DJ, Serrano N, Zito F, Jones L, Montgomery HE, Rumley A, Sharma P, Lowe GD, World MJ, Humphries SE, Hingorani AD (2003). Human CRP gene polymorphism influences CRP levels: implications for the prediction and pathogenesis of coronary heart disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 23(11), 2063 - 2069.
    • Talmud PJ, Wright R, Steiner G, Syvanne M, Humphries SE (2003). Risk of ischemic heart and ischemic cerebrovascular disease is not increased in S, Z, and 11478A alpha(1)-antitrypsin - Carriers of the Copenhagen City Heart Study - Response. ARTERIOSCL THROM VAS, 23(11), - .
    • Juhan-Vague I, Morange PE, Frere C, Aillaud MF, Alessi MC, Hawe E, Boquist S, Tornvall P, Yudkin JS, Tremoli E, Margaglione M, Di Minno G, Hamsten A, Humphries SE (2003). The plasminogen activator inhibitor-1 -675 4G/5G genotype influences the risk of myocardial infarction associated with elevated plasma proinsulin and insulin concentrations in men from Europe: the HIFMECH study. Journal of Thrombosis and Haemostasis, 1(11), 2322 - 2329.
    • Carew JA, Basso F, Miller GJ, Hawe E, Jackson AA, Humphries SE, Bauer KA (2003). A functional haplotype in the 5' flanking region of the factor VII gene is associated with an increased risk of coronary heart disease. Journal of Thrombosis and Haemostasis, 1(10), 2179 - 2185.
    • Jones A, Dhamrait SS, Payne JR, Hawe E, Li P, Toor IS, Luong L, Wootton PT, Miller GJ, Humphries SE, Montgomery HE (2003). Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension. Hypertension, 42(4), 500 - 506.
    • Neil HA, Huxley RR, Hawkins MM, Durrington PN, Betteridge DJ, Humphries SE (2003). Comparison of the risk of fatal coronary heart disease in treated xanthomatous and non-xanthomatous heterozygous familial hypercholesterolaemia: a prospective registry study. Atherosclerosis, 170(1), 73 - 78.
    • Kelberman D, Fife M, Rockman MV, Brull DJ, Woo P, Humphries SE (2003). Functional and evolutionary analysis of the IL-6 AnTn tract promoter polymorphism.
    • Humphries SE (2003). The stromelysin-1 (MMP-3) gene and risk of coronary artery disease: a candidate gene that has won the election?. Thrombosis and Haemostasis, 90(1), 3 - 6.

    2002

    • Jenny NS, Tracy RP, Ogg MS, Luong LA, Kuller LH, Arnold AM, Sharrett AR, Humphries SE (2002). In the elderly, interleukin-6 plasma levels and the -174G>C polymorphism are associated with the development of cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 22(12), 2066 - 2071.
    • Brull DJ, Leeson CP, Montgomery HE, Mullen M, deDivitiis M, Humphries SE, Deanfield JE, Lesson CP (2002). The effect of the Interleukin-6-174G > C promoter gene polymorphism on endothelial function in healthy volunteers. European Journal of Clinical Investigation, 32(3), 153 - 157.
    • Gomma AH, Elrayess MA, Knight CJ, Hawe E, Fox KM, Humphries SE (2002). The endothelial nitric oxide synthase (Glu298Asp and -786T>C) gene polymorphisms are associated with coronary in-stent restenosis. European Heart Journal, 23(24), 1955 - 1962.
    • Talmud P, Hawe E, Martin S, Olivier M, Miller GJ, Rubin EM, Pennacchio LA, Humphries SE (2002). Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. Human Molecular Genetics, 11(24), 3039 - 3046. doi:10.1093/hmg/11.24.3039
    • Dhamrait SS, Jones A, Brull DJ, Myerson S, World M, Pennell D, Humphries SE (2002). A variant in the gene for a human mitochondrial uncoupling protein is associated with left ventricular mass after training.
    • Woods DR, Jones A, Sanders J, Hawe E, Hurel S, Hindmarsh P, Pringle J, Humphries SE, Montgomery HE (2002). Exercise-induced rise in insulin-like growth factor-1 is angiotensin converting enzyme genotype dependent.
    • Flavell D, Wootton P, Montgomery H, Humphries SE, Talmud PJ (2002). Lipoprotein lipase genotype influences exercise-induced cardiac growth.
    • Zito F, Lowe GD, Rumley A, McMahon AD, Humphries SE (2002). Association of the factor XII 46C>T polymorphism with risk of coronary heart disease (CHD) in the WOSCOPS study. Atherosclerosis, 165(1), 153 - 158.
    • Harding D, Baines PB, Brull D, Vassiliou V, Ellis I, Hart A, Thomson AP, Humphries SE, Montgomery HE (2002). Severity of meningococcal disease in children and the angiotensin- converting enzyme insertion/deletion polymorphism. American Journal of Respiratory and Critical Care Medicine, 165(8), 1103 - 1106. doi:10.1164/rccm.2108089
    • Talmud PJ, Hawe E, Miller GJ, Humphries SE (2002). Nonfasting apolipoprotein B and triglyceride levels as a useful predictor of coronary heart disease risk in middle-aged UK men. Arteriosclerosis, Thrombosis, and Vascular Biology, 22(11), 1918 - 1923.
    • Talmud PJ, Humphries SE (2002). Gene:environment interaction in lipid metabolism and effect on coronary heart disease risk. Current Opinion in Lipidology, 13(2), 149 - 154.
    • Basso F, Lowe GD, Rumley A, McMahon AD, Humphries SE (2002). Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS). Arteriosclerosis, Thrombosis, and Vascular Biology, 22(4), 599 - 604.
    • Flavell DM, Jamshidi Y, Hawe E, Pineda T, I T, M R F, M H N, M S K, Y A P, A S, B M, G H, S E T, P J S, M (2002). Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease. Circulation, 105(12), 1440 - 1445.
    • Jamshidi Y, Montgomery HE, Hense HW, Myerson SG, Torra IP, Staels B, World MJ, Doering A, Erdmann J, Hengstenberg C, Humphries SE, Schunkert H, Flavell DM (2002). Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension. Circulation, 105(8), 950 - 955.
    • Sniderman AD, Castro CM, Ribalta J, Carmena R, de Bruin TW, de Graaf J, Erkelens DW, Humphries SE, Masana L, Real JT, Talmud PJ, Taskinen MR (2002). A proposal to redefine familial combined hyperlipidaemia -- third workshop on FCHL held in Barcelona from 3 to 5 May 2001, during the scientific sessions of the European Society for Clinical Investigation. European Journal of Clinical Investigation, 32(2), 71 - 73.
    • Humphries SE, Donati MB (2002). Analysis of gene-environment interaction in coronary artery disease. Italian Heart Journal, 3(1), 3 - 5.
    • Montgomery H, Brull D, Humphries SE (2002). Analysis of gene-environment interactions by "stressing-the-genotype" studies: the angiotensin converting enzyme and exercise-induced left ventricular hypertrophy as an example. Italian Heart Journal, 3(1), 10 - 14.
    • Woods DR, World M, Rayson MP, Williams AG, Jubb M, Jamshidi Y, Hayward M, Mary DA, Humphries SE, Montgomery HE (2002). Endurance enhancement related to the human angiotensin I-converting enzyme I-D polymorphism is not due to differences in the cardiorespiratory response to training. European Journal of Applied Physiology and Occupational Physiology, 86(3), 240 - 244.
    • Whittall RA, Matheus S, Cranston T, Miller GJ, Humphries SE (2002). The intron 14 2140+5G>A variant in the low density lipoprotein receptor gene has no effect on plasma cholesterol levels. Journal of Medical Genetics, 39(9), e57 - .
    • Woods DR, Pollard AJ, Collier DJ, Jamshidi Y, Vassiliou V, Hawe E, Humphries SE, Montgomery HE (2002). Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene and arterial oxygen saturation at high altitude. American Journal of Respiratory and Critical Care Medicine, 166(3), 362 - 366. doi:10.1164/rccm.2103060
    • Humphries SE, Berglund L, Isasi CR, Otvos JD, Kaluski D, Deckelbaum RJ, Shea S, Talmud PJ (2002). Loci for CETP, LPL, LIPC, and APOC3 affect plasma lipoprotein size and sub-population distribution in Hispanic and non-Hispanic white subjects: the Columbia University BioMarkers Study. Nutrition, Metabolism and Cardiovascular Diseases, 12(4), 163 - 172.
    • Gomma A, Elrayess MA, Hawe E, Humphries SE, Fox KM (2002). The endothelial nitric oxide synthase (eNOS) gene polymorphism (Glu298Asp) is associated with coronary in-stent restenosis.
    • Jamshidi Y, Flavell DM, Hawe E, MacCallum PK, Meade TW, Humphries SE (2002). Genetic determinants of the response to bezafibrate treatment in the lower extremity arterial disease event reduction (LEADER) trial. Atherosclerosis, 163(1), 183 - 192.
    • Austin MA, Zimmern RL, Humphries SE (2002). High "population attributable fraction" for coronary heart disease mortality among relatives in monogenic familial hypercholesterolemia. Genetics in Medicine, 4(4), 275 - 278.
    • Montgomery H, Humphries S, Danilov S (2002). Is genotype or phenotype the better tool for investigating the role of ACE in human cardiovascular disease?. European Heart Journal, 23(14), 1083 - 1086.
    • Marks D, Wonderling D, Thorogood M, Lambert H, Humphries SE, Neil HA (2002). Cost effectiveness analysis of different approaches of screening for familial hypercholesterolaemia. BMJ (Clinical Research Ed.), 324(7349), 1303 - .
    • Rundek T, Elkind MS, Pittman J, Boden-Albala B, Martin S, Humphries SE, Juo SH, Sacco RL (2002). Carotid intima-media thickness is associated with allelic variants of stromelysin-1, interleukin-6, and hepatic lipase genes: the Northern Manhattan Prospective Cohort Study. Stroke, 33(5), 1420 - 1423.
    • Humphries S, Bauters C, Meirhaeghe A, Luong L, Bertrand M, Amouyel P (2002). The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis. European Heart Journal, 23(9), 721 - 725.
    • Brull DJ, Sanders J, Rumley A, Lowe GD, Humphries SE, Montgomery HE (2002). Impact of angiotensin converting enzyme inhibition on post-coronary artery bypass interleukin 6 release. Heart, 87(3), 252 - 255.
    • Brull DJ, Dhamrait S, Moulding R, Rumley A, Lowe GD, World MJ, Humphries SE, Montgomery HE (2002). The effect of fibrinogen genotype on fibrinogen levels after strenuous physical exercise. Thrombosis and Haemostasis, 87(1), 37 - 41.
    • Humphries SE, Martin S, Cooper J, Miller G (2002). Interaction between smoking and the stromelysin-1 (MMP3) gene 5A/6A promoter polymorphism and risk of coronary heart disease in healthy men. Annals of Human Genetics, 66(Pt 6), 343 - 352.
    • Talmud PJ, Hawe E, Robertson K, Miller GJ, Miller NE, Humphries SE (2002). Genetic and environmental determinants of plasma high density lipoprotein cholesterol and apolipoprotein AI concentrations in healthy middle-aged men. Annals of Human Genetics, 66(Pt 2), 111 - 124.
    • Marshall RP, Webb S, Hill MR, Humphries SE, Laurent GJ (2002). Genetic polymorphisms associated with susceptibility and outcome in ARDS. Chest, 121(3 Supp), 68S - 69S.
    • Papafili A, Hill MR, Brull DJ, McAnulty RJ, Marshall RP, Humphries SE, Laurent GJ (2002). Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response. Arteriosclerosis, Thrombosis, and Vascular Biology, 22(10), 1631 - 1636. doi:10.1161/01.ATV.0000030340.80207.C5
    • Marshall RP, Webb S, Bellingan GJ, Montgomery HE, Chaudhari B, McAnulty RJ, Humphries SE, Hill MR, Laurent GJ (2002). Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine, 166(5), 646 - 650. doi:10.1164/rccm.2108086
    • Colhoun HM, Zito F, Norman CN, Rubens MB, Fuller JH, Humphries SE (2002). Activated factor XII levels and factor XII 46C>T genotype in relation to coronary artery calcification in patients with type 1 diabetes and healthy subjects. Atherosclerosis, 163(2), 363 - 369.
    • Leeson CP, Hingorani AD, Mullen MJ, Jeerooburkhan N, Kattenhorn M, Cole TJ, Muller DP, Lucas A, Humphries SE, Deanfield JE (2002). Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function. Circulation Research, 90(11), 1153 - 1158. doi:10.1161/01.RES.0000020562.07492.D4
    • Juhan-Vague I, Morange PE, Aubert H, Henry M, Aillaud MF, Alessi MC, Samnegard A, Hawe E, Yudkin J, Margaglione M, Di Minno G, Hamsten A, Humphries SE (2002). Plasma thrombin-activatable fibrinolysis inhibitor antigen concentration and genotype in relation to myocardial infarction in the north and south of Europe. Arteriosclerosis, Thrombosis, and Vascular Biology, 22(5), 867 - 873.
    • Li LK, Humphries SE, Wood N (2002). Simultaneous determination of apolipoprotein AIV T347S and Q360H genotypes using a heteroduplex generator. Atherosclerosis, 165(2), 385 - 388.

    2001

    • Eiriksdottir G, Bolla MK, Thorsson B, Sigurdsson G, Humphries SE, Gudnason V (2001). The -629C>A polymorphism in the CETP gene does not explain the association of TaqIB polymorphism with risk and age of myocardial infarction in Icelandic men. Atherosclerosis, 159(1), 187 - 192.
    • Brull D, Dhamrait S, Myerson S, Erdmann J, Woods D, World M, Pennell D, Humphries S, Regitz-Zagrosek V, Montgomery H (2001). Bradykinin B2BKR receptor polymorphism and left-ventricular growth response. The Lancet, 358(9288), 1155 - 1156. doi:10.1016/S0140-6736(01)06273-0
    • Talmud PJ, Berglund L, Hawe EM, Waterworth DM, Isasi CR, Deckelbaum RE, Starc T, Ginsberg HN, Humphries SE, Shea S (2001). Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study. Pediatrics, 108(3), E50 - .
    • Brull DJ, Murray LJ, Boreham CA, Ralston SH, Montgomery HE, Gallagher AM, McGuigan FE, Davey SG, Savage M, Humphries SE, Young IS (2001). Effect of a COL1A1 Sp1 binding site polymorphism on arterial pulse wave velocity: an index of compliance. Hypertension, 38(3), 444 - 448.
    • Flavell D, Talmud PJ, Day INM, Miller G, Humphries SE (2001). Gene : environment interactions in determination of risk of coronary artery disease. J MED GENET, 38, S12 - S12.
    • Talmud PJ, Humphries SE (2001). Genetic polymorphisms, lipoproteins and coronary artery disease risk. CURRENT OPINIONS IN LIPIDOLOGY, 12(4), 405 - 409.
    • Humphries SE, Talmud PJ, Hawe E, Bolla M, Day IN, Miller GJ (2001). Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study. The Lancet, 358(9276), 115 - 119. doi:10.1016/S0140-6736(01)05330-2
    • Curran JM, Fatah-Ardalani K, Tornvall P, Humphries SE, Green FR (2001). A hypothesis to explain the reported association of the alpha- fibrinogen A312 allele with thromboembolic disease. Thrombosis and Haemostasis, 85(6), 1122 - 1123.
    • Jones KG, Brull DJ, Brown LC, Sian M, Greenhalgh RM, Humphries SE, Powell JT (2001). Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. Circulation, 103, 2260 - 2265.
    • Benhizia F, Ginsberg HN, Humphries SE, Talmud PJ (2001). Variation in the human ApoB signal peptide modulates ApoB17 translocation. Biochemical and Biophysical Research Communications, 283(1), 149 - 157.
    • Cook DG, Cappuccio FP, Atkinson RW, Wicks PD, Chitolie A, Nakandakare ER, Sagnella GA, Humphries SE (2001). Ethnic differences in fibrinogen levels: the role of environmental factors and the beta-fibrinogen gene. American Journal of Epidemiology, 153(8), 799 - 806.
    • Jones KG, Brown LC, Brull DJ, Humphries SE, Greenhalgh RM, Powell JT (2001). Interleukin 6 and the prognosis of abdominal aortic aneurysms. BRIT J SURG, 88(4), 601 - 602.
    • Hubacek JA, Waterworth DM, Poledne R, Pitha J, Skodova Z, Humphries SE, Talmud PJ (2001). Genetic determination of plasma lipids and insulin in the Czech population. Clinical Biochemistry, 34(2), 113 - 118.
    • Steed L, Kong R, Stygall J, Acharya J, Bolla M, Harrison MJ, Humphries SE, Newman SP (2001). The role of apolipoprotein E in cognitive decline after cardiac operation. The Annals of Thoracic Surgery, 71(3), 823 - 826.
    • Waterworth DM, Talmud PJ, Humphries SE, Wicks PD, Sagnella GA, Strazzullo P, Alberti KG, Cook DG, Cappuccio FP (2001). Variable effects of the APOC3-482C > T variant on insulin, glucose and triglyceride concentrations in different ethnic groups. Diabetologia, 44(2), 245 - 248.
    • Webb KE, Martin JF, Hamsten A, Eriksson P, Iacoviello L, Gattone M, Donati MB, Di Castelnuovo A, Erusalimsky J, Humphries SE (2001). Polymorphisms in the thrombopoietin gene are associated with risk of myocardial infarction at a young age. Atherosclerosis, 154(3), 703 - 711.
    • Dekou V, Whincup P, Papacosta O, Ebrahim S, Lennon L, Ueland PM, Refsum H, Humphries SE, Gudnason V (2001). The effect of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase gene on homocysteine levels in elderly men and women from the British regional heart study. Atherosclerosis, 154(3), 659 - 666.
    • Ferrari SL, Garnero P, Emond S, Montgomery H, Humphries SE, Greenspan SL (2001). A functional polymorphic variant in the interleukin-6 gene promoter associated with low bone resorption in postmenopausal women. Arthritis and Rheumatism, 44(1), 196 - 201.
    • Heath KE, Humphries SE, Middleton-Price H, Boxer M (2001). A molecular genetic service for diagnosing individuals with familial hypercholesterolaemia (FH) in the United Kingdom. European Journal of Human Genetics, 9(4), 244 - 252.
    • Woods D, Onambele G, Woledge R, Skelton D, Bruce S, Humphries SE, Montgomery H (2001). Angiotensin-I converting enzyme genotype-dependent benefit from hormone replacement therapy in isometric muscle strength and bone mineral density. Journal of Clinical Endocrinology and Metabolism, 86(5), 2200 - 2204.
    • Talmud PJ, Waterworth DM, Humphries SE (2001). Effect of genetic variation on the postprandial response. Results from the European Atherosclerosis Research Study II. WORLD REVIEW OF NUTRITION AND DIET, 89, 53 - 60.
    • Woods D, Hickman M, Jamshidi Y, Brull D, Vassiliou V, Jones A, Humphries S, Montgomery H (2001). Elite swimmers and the D allele of the ACE I/D polymorphism. Human Genetics, 108(3), 230 - 232.
    • Dekou V, Gudnason V, Hawe E, Miller GJ, Stansbie D, Humphries SE (2001). Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged men. Thrombosis and Haemostasis, 85(1), 67 - 74.
    • Brull DJ, Montgomery HE, Sanders J, Dhamrait S, Luong L, Rumley A, Lowe GD, Humphries SE (2001). Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arteriosclerosis, Thrombosis, and Vascular Biology, 21(9), 1458 - 1463.
    • Myerson SG, Montgomery HE, Whittingham M, Jubb M, World MJ, Humphries SE, Pennell DJ (2001). Left Ventricular Hypertrophy With Exercise and ACE Gene Insertion/Deletion Polymorphism : A Randomized Controlled Trial With Losartan. Circulation, 103(2), 226 - 230.
    • Seed M, Ayres KL, Humphries SE, Miller GJ (2001). Lipoprotein (a) as a predictor of myocardial infarction in middle-aged men. The American Journal of Medicine, 110(1), 22 - 27.
    • Heath KE, Gahan M, Whittall RA, Humphries SE (2001). Low-density lipoprotein receptor gene (LDLR) world-wide website in familial hypercholesterolaemia: update, new features and mutation analysis. Atherosclerosis, 154(1), 243 - 246.
    • Hubacek JA, Waterworth DM, Pitha J, Humphries SE, Talmud PJ, Poledne R (2001). Polymorphisms in the lipoprotein lipase and hepatic lipase genes and plasma lipid values in the Czech population. PHYSIOLOGICAL RESEARCH, 50(4), 345 - 351.
    • Humphries SE, Montgomery HE, Talmud PJ (2001). Predisposing genes, high-risk environments and coronary artery disease: LPL and fibrinogen as examples. WORLD REVIEW OF NUTRITION AND DIET, 89, 61 - 67.
    • Rundek S, Elkind MS, Boden-Albala B, Humphries SE, Sacco RL (2001). The association of carotid artery intimal-medial thickness and allelic variants of stromelysin-1, interleukin-6 and hepatic lipase genes: A pilot study from the Northern Manhattan Stroke Study. STROKE, 32(1), 336 - 336.
    • Dekou V, Whincup P, Papacosta O, Ebrahim S, Lennon L, Ueland PM, Refsum H, Humphries SE, Gudnason V (2001). The effect of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase gene on homocysteine levels in elderly men and women from the British regional heart study. Atherosclerosis, 154(3), 659 - 666.
    • (2001). The role of Apolipoprotein E in cognitive decline following cardiac surgery. The Annals of Thoracic Surgery, 71, 823 - 826.
    • Mohamed-Ali V, Flower L, Sethi J, Hotamisligil G, Gray R, Humphries SE, York DA, Pinkney J (2001). beta-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies. Journal of Clinical Endocrinology and Metabolism, 86(12), 5864 - 5869. doi:10.1210/jc.86.12.5864
    • Humphries SE, Luong LA, Ogg MS, Hawe E, Miller GJ (2001). The interleukin-6 -174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men. European Heart Journal, 22(24), 2243 - 2252.
    • Jeerooburkhan N, Jones LC, Bujac S, Cooper JA, Miller GJ, Vallance P, Humphries SE, Hingorani AD (2001). Genetic and environmental determinants of plasma nitrogen oxides and risk of ischemic heart disease. Hypertension, 38(5), 1054 - 1061.
    • Humphries SE, Ordovas JM (2001). Genetics and atherosclerosis: broadening the horizon. Atherosclerosis, 154(3), 517 - 519.
    • Brull DJ, Leeson P, Mullen M, deDiviitis M, Montgomery HE, Deanfield JE, Humphries SE (2001). The effect of the interleukin-6-174G > C promoter gene polymorphism on endothelial function. Journal of the American College of Cardiology, 37(2), 276A - +.
    • (2001). The Glu298-Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function Leeson CP,. Circulation, 102(18), 1366 - .
    • Brull DJ, Sanders J, Rumley A, Lowe GD, Humphries SE, Montgomery HE (2001). Statin therapy and the acute inflammatory response after coronary artery bypass grafting. The American Journal of Cardiology, 88(4), 431 - 433.

    2000

    • Hamsten A, Syvanne M, Silveira A, Luong LA, Nieminen MS, Humphries S, Frick MH, Taskinen MR (2000). Fibrinolytic proteins and progression of coronary artery disease in relation to gemfibrozil therapy. Thrombosis and Haemostasis, 83(3), 397 - 403.
    • Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V (2000). Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?. Atherosclerosis, 148(2), 209 - 214.
    • Talmud PJ, Bujac SR, Hall S, Miller GJ, Humphries SE (2000). Substitution of asparagine for aspartic acid at residue 9 (D9N) of lipoprotein lipase markedly augments risk of ischaemic heart disease in male smokers. Atherosclerosis, 149(1), 75 - 81.
    • Williams AG, Rayson MP, Jubb M, World M, Woods DR, Hayward M, Martin J, Humphries SE, Montgomery HE (2000). The ACE gene and muscle performance. Nature, 403(6770), 614 - .
    • Minihane AM, Talmund PJ, Humphries SE, Murphy MC, Griffin BA, Williams CM (2000). An adverse low density lipoprotein-cholesterol response to fish oil supplementation is observed in subjects with an apoE4 genotype.. P NUTR SOC, 59, 67A - 67A.
    • Marks D, Wonderling D, Thorogood M, Lambert H, Humphries SE, Neil HA (2000). Screening for hypercholesterolaemia versus case finding for familial hypercholesterolaemia: a systematic review and cost-effectiveness analysis. Health Technology Assessment, 4(29), 1 - 123.
    • Rauramaa R, Vaisanen SB, Luong LA, Schmidt-Trucksass A, Penttila IM, Bouchard C, Toyry J, Humphries SE (2000). Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 20(12), 2657 - 2662.
    • Woods DR, Humphries SE, Montgomery HE (2000). The ACE I/D polymorphism and human physical performance. Trends in Endocrinology and Metabolism, 11(10), 416 - 420.
    • Flower L, Ahuja RH, Humphries SE, Mohamed-Ali V (2000). Effects of sample handling on the stability of interleukin 6, tumour necrosis factor-alpha and leptin. Cytokine, 12(11), 1712 - 1716.
    • Cotton JM, Webb KE, Mathur A, Martin JF, Humphries SE (2000). Impact of the -455G>A promoter polymorphism in the B fibrinogen gene on stimulated fibrinogen production following bypass surgery. Thrombosis and Haemostasis, 84(5), 926 - 927.
    • Rauramaa R, Vaisanen SB, Luong LA, Schmidt-Trucksass A, Penttila IM, Bouchard C, Toyry J, Humphries SE (2000). Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis. CIRCULATION, 102(18), 50 - 50.
    • Zito F, Drummond F, Bujac SR, Esnouf MP, Morrissey JH, Humphries SE, Miller GJ (2000). Epidemiological and genetic associations of activated factor XII concentration with factor VII activity, fibrinopeptide A concentration, and risk of coronary heart disease in men. Circulation, 102(17), 2058 - 2062.
    • Woods A, Brull DJ, Humphries SE, Montgomery HE (2000). Genetics of inflammation and risk of coronary artery disease: the central role of interleukin-6. European Heart Journal, 21(19), 1574 - 1583.
    • Wallace AJ, Mann JI, Sutherland WH, Williams S, Chisholm A, Skeaff CM, Gudnason V, Talmud PJ, Humphries SE (2000). Variants in the cholesterol ester transfer protein and lipoprotein lipase genes are predictors of plasma cholesterol response to dietary change. Atherosclerosis, 152(2), 327 - 336.
    • Heath KE, Whittal RA, Miller GJ, Humphries S (2000). I705 variant in the low denisty lipoprotein receptor gene has no effect on plasma cholesterol levels. Journal of Medical Genetics, 37(9), 713 - 715.
    • Bauer KA, Humphries S, Smillie B, Li L, Cooper JA, Barzegar S, Rosenberg RD, Miller GJ (2000). Prothrombin activation is increased among asymptomatic carriers of the prothrombin G20210A and factor V Arg506Gln mutations. Thrombosis and Haemostasis, 84(3), 396 - 400.
    • Friedlander Y, Talmud PJ, Edwards KL, Humphries SE, Austin MA (2000). Sib-pair linkage analysis of longitudinal changes in lipoprotein risk factors and lipase genes in women twins. The Journal of Lipid Research, 41(8), 1302 - 1309.
    • Xu W, Humphries S, Tomita M, Okuyama T, Matsuki M, Burgner D, Kwiatkowski D, Liu L, Charles IG (2000). Survey of the allelic frequency of a NOS2A promoter microsatellite in human populations: assessment of the NOS2A gene and predisposition to infectious disease. Nitric Oxide, 4(4), 379 - 383.
    • Neil HA, Hammond T, Huxley R, Matthews DR, Humphries SE (2000). Extent of underdiagnosis of familial hypercholesterolaemia in routine practice: prospective registry study. BMJ (Clinical Research Ed.), 321(7254), 148 - .
    • Talmud PJ, Palmen J, Miller G, Humphries SE (2000). Effect of microsomal triglyceride transfer protein gene variants (-493G > T, Q95H and H297Q) on plasma lipid levels in healthy middle-aged UK men. Annals of Human Genetics, 64(Pt 4), 269 - 276.
    • Waterworth DM, Hubacek JA, Pitha J, Kovar J, Poledne R, Humphries SE, Talmud PJ (2000). Plasma levels of remnant particles are determined in part by variation in the APOC3 gene insulin response element and the APOCI-APOE cluster. The Journal of Lipid Research, 41(7), 1103 - 1109.
    • Talmud PJ, Edwards KL, Turner CM, Newman B, Palmen JM, Humphries SE, Austin MA (2000). Linkage of the cholesteryl ester transfer protein (CETP) gene to LDL particle size: use of a novel tetranucleotide repeat within the CETP promoter. Circulation, 101(21), 2461 - 2466.
    • Bolla MK, Martin SG, Wood NA, Humphries SE (2000). Genotyping of the stromelysin-1 5A/6A promoter polymorphism using a heteroduplex generator. Thrombosis and Haemostasis, 83(5), 790 - 792.
    • Flavell DM, Pineda T, I J, Y E, D D, J R E, R S B, S R M, G T, P J S, B H, S E (2000). Variation in the PPARalpha gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects. Diabetologia, 43(5), 673 - 680.
    • Wallace AJ, Humphries SE, Fisher RM, Mann JI, Chisholm A, Sutherland WH (2000). Genetic factors associated with response of LDL subfractions to change in the nature of dietary fat. Atherosclerosis, 149(2), 387 - 394.
    • Heath KE, Day IN, Humphries SE (2000). Universal primer quantitative fluorescent multiplex (UPQFM) PCR: a method to detect major and minor rearrangements of the low density lipoprotein receptor gene. Journal of Medical Genetics, 37(4), 272 - 280.
    • Waterworth DM, Talmud PJ, Bujac SR, Fisher RM, Miller GJ, Humphries SE (2000). Contribution of apolipoprotein C-III gene variants to determination of triglyceride levels and interaction with smoking in middle-aged men. Arteriosclerosis, Thrombosis, and Vascular Biology, 20(12), 2663 - 2669.
    • Liu H, Labeur C, Xu CF, Ferrell R, Lins L, Brasseur R, Rosseneu M, Weiss KM, Humphries SE, Talmud PJ (2000). Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr. The Journal of Lipid Research, 41(11), 1760 - 1771.
    • Leeson CP, Hingorani AD, Mullen MJ, Jeerooburkhan N, Kattenhorn M, Muller DP, Lucas A, Humphries SE, Deanfield JE (2000). The Glu298-Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function. CIRCULATION, 102(18), 279 - 279.
    • Cotton J, Webb KE, Mathur A, Martin JF, Humphries SE (2000). -455G/A polymorphism of the beta-fibrinogen gene is associated with marked alterations in the fibrinogen response following cardiopulmonary bypass surgery. EUR HEART J, 21, 279 - 279.
    • Watts GF, Riches FM, Humphries SE, Talmud PJ, van Bockxmeer FM (2000). Genotypic associations of the hepatic secretion of VLDL apolipoprotein B-100 in obesity. The Journal of Lipid Research, 41(3), 481 - 488.

    1999

    • Heath K, Rickard SJ, Day INM, Humphries SE, Boxer M (1999). Molecular analysis of patients with familial hypercholesterolaemia (FH): evaluation of two high-throughput mutation analysis systems. J MED GENET, 36, S92 - S92.
    • Dallongeville J, Tiret L, Visvikis S, O'Reilly DSJ, Saava M, Tsitouris G, Rosseneu M, DeBacker G, Humphries SE, Beisiegel U, EARS Grp (1999). Effect of apo E phenotype on plasma postprandial triglyceride levels in young male adults with and without a familial history of myocardial infarction: the EARS II study. ATHEROSCLEROSIS, 145(2), 381 - 388.
    • Ogg MS, Brennan P, Meade T, Humphries SE (1999). CYP2C9*3 allelic variant and bleeding complications. LANCET, 354(9184), 1124 - 1124.
    • Ogg MS, Luong LA, Bujac SR, Miller GJ, Humphries SE (1999). The interleukin-6-174 G/C promoter polymorphism is associated with systolic blood pressure in healthy men in the Northwick Park Heart Study II (NPHSII). ATHEROSCLEROSIS, 147(1), 208 - 208.
    • Myerson SG, Montgomery HE, Whittingham M, Jubb M, World MJ, Humphries SE, Pennell DJ (1999). Losartan does not prevent the excess left ventricular growth response to exercise seen in normal subjects of angiotensin converting enzyme DD genotype. CIRCULATION, 100(18), 161 - 161.
    • Haddad L, Day IN, Hunt S, Williams RR, Humphries SE, Hopkins PN (1999). Evidence for a third genetic locus causing familial hypercholesterolemia. A non-LDLR, non-APOB kindred. The Journal of Lipid Research, 40(6), 1113 - 1122.
    • Ogg MS, Brennan P, Meade T, Humphries SE (1999). CYP2C9*3 allelic variant and bleeding complications [letter]. The Lancet, 354(9184), 1124 - 1124.
    • Fisher RM, Burke H, Nicaud V, Enholm C, Humphries SE (1999). Effect of variation in the apoA-IV gene on body mass index and fasting and postprandial lipids in the European Atherosclerosis Research Study II. The Journal of Lipid Research, 40, 287 - 294.
    • Heath KE, Gudnason V, Humphries SE, Seed M (1999). The type of mutation in the low density lipoprotein receptor gene influences the cholesterol-lowering response of the HMG-CoA reductase inhibitor simvastatin in patients with heterozygous familial hypercholesterolaemia. Atherosclerosis, 143(1), 41 - 54.
    • Humphries SE, Henry JA, Montgomery HE (1999). Gene-environment interaction in the determination of levels of haemostatic variables involved in thrombosis and fibrinolysis. Blood Coagulation and Fibrinolysis, 10 Sup, S17 - S21.
    • Dollery CM, Humphries SE, McClelland A, Latchman DS, McEwan JR (1999). Expression of tissue inhibitor of matrix metalloproteinases 1 by use of an adenoviral vector inhibits smooth muscle cell migration and reduces neointimal hyperplasia in the rat model of vascular balloon injury. Circulation, 99(24), 3199 - 3205.
    • de Maat MP, Jukema JW, Ye S, Zwinderman AH, Moghaddam PH, Beekman M, Kastelein JJ, van Boven AJ, Bruschke AV, Humphries SE, Kluft C, Henney AM (1999). Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis. The American Journal of Cardiology, 83(6), 852 - 856.
    • Dallongeville J, Tiret L, Visvikis S, O'Reilly DS, Saava M, Tsitouris G, Rosseneu M, DeBacker G, Humphries SE, Beisiegel U (1999). Effect of apo E phenotype on plasma postprandial triglyceride levels in young male adults with and without a familial history of myocardial infarction: the EARS II study. European Atherosclerosis Research Study. ATHEROSCLEROSIS, 145(2), 381 - 388.
    • Sanders TA, de Grassi T, Miller GJ, Humphries SE (1999). Dietary oleic and palmitic acids and postprandial factor VII in middle-aged men heterozygous and homozygous for factor VII R353Q polymorphism. American Journal of Clinical Nutrition, 69(2), 220 - 225.
    • Montgomery H, Clarkson P, Barnard M, Bell J, Brynes A, Dollery C, Hajnal J, Hemingway H, Mercer D, Jarman P, Marshall R, Prasad K, Rayson M, Saeed N, Talmud P, Thomas L, Jubb M, World M, Humphries S (1999). Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training [see comments]. The Lancet, 353(9152), 541 - 545.
    • Montgomery H, Clarkson P, Barnard M, Bell J, Brynes A, Dollery C, Hajnal J, Hemingway H, Mercer D, Jarman P, Marshall R, Prasad K, Rayson M, Saeed N, Talmud P, Thomas L, Jubb M, World M, Humphries S (1999). Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training. LANCET, 353(9152), 541 - 545.
    • Gudnason V, Kakko S, Nicaud V, Savolainen MJ, Kesaniemi YA, Tahvanainen E, Humphries S (1999). Cholesteryl ester transfer protein gene effect on CETP activity and plasma high-density lipoprotein in European populations. The EARS Group. European Journal of Clinical Investigation, 29(2), 116 - 128.
    • Gudnason V, Humphries SE (1999). Hyperhomocysteinaemia, genetics and cardiovascular disease risk. EUR HEART J, 20(8), 552 - 553.
    • Waterworth DM, Ribalta J, Nicaud V, Dallongeville J, Humphries SE, Talmud P (1999). ApoCIII gene variants modulate postprandial response to both glucose and fat tolerance tests.. Circulation, 99(14), 1872 - 1877.
    • Talmud PJ, Waterworth DM, Humphries SE (1999). The contribution of genetic variation to the postprandial response: Results from the European atherosclerosis research study (EARSII). ATHEROSCLEROSIS, 144, 81 - 81.
    • Watts GF, Riches FM, Humphries SE, Talmud PJ, van Bockxmeer FM (1999). Role of microsomal triglyceride transfer protein, apoB signal peptide and apoe genes in determining the hepatic secretion of apolipoprotein B-100 in obesity. ATHEROSCLEROSIS, 144, 4 - 4.
    • Bolla MK, Wood N, Humphries SE (1999). Rapid determination of apolipoprotein E genotype using a heteroduplex generator. The Journal of Lipid Research, 40(12), 2340 - 2345.
    • Heath KE, Humphries SE (1999). Rapid detection of polymorphisms in exons 10, 11 and 12 of the low density lipoprotein receptor gene (LDLR) and their use in a clinical genetic diagnostic setting [letter]. CLIN GENET, 55(3), 212 - 214.
    • Dollery CM, Humphries SE, McClelland A, Latchman DS, McEwan JR (1999). In vivo adenoviral gene transfer of TIMP-1 after vascular injury reduces neointimal formation. Annals of the New York Academy of Sciences, 878, 742 - 743.
    • Gudnason V, Humphries SE (1999). Hyperhomocysteinaemia, genetics and cardiovascular disease risk [editorial; comment]. European Heart Journal, 20(8), 552 - 553.
    • Myerson S, Hemingway H, Budget R, Martin J, Humphries S, Montgomery H (1999). Human angiotensin I-converting enzyme gene and endurance performance. Journal of Applied Physiology, 87(4), 1313 - 1316.
    • Humphries SE, Luong LA, Montgomery HE, Day IN, Mohamed Ali V, Yudkin JS (1999). Gene-environment interaction in the determination of levels of plasma fibrinogen. Thrombosis and Haemostasis, 82(2), 818 - 825.
    • Grant PJ, Humphries SE (1999). Genetic determinants of arterial thrombosis. BEST PRACT RES CL HA, 12(3), 505 - 532.

    1998

    • Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, Woo P (1998). The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest, 102(7), 1369 - 1376.
    • Fishman D, Faulds G, Jeffery R, Mohamed A, Yudkin JS, Humphries S, Woo P (1998). The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J CLIN INVEST, 102(7), 1369 - 1376.
    • Curran JM, Evans A, Arveiler D, Luc G, Ruidavets JB, Humphries SE, Green FR (1998). The alpha fibrinogen T/A312 polymorphism in the ECTIM study [letter]. THROMB HAEMOST, 79(5), 1057 - 1058.
    • Humphries SE, Luong LA, Talmud PJ, Frick MH, Kesaniemi YA, Pasternack A, Taskinen MR, Syvanne M (1998). The 5A/6A polymorphism in the promoter of the stromelysin-1 (MMP-3) gene predicts progression of angiographically determined coronary artery disease in men in the LOCAT gemfibrozil study. Lopid Coronary Angiography Trial. ATHEROSCLEROSIS, 139(1), 49 - 56.
    • Wenham PR, Haddad L, Panarelli M, Ashby JP, Day IN, Giles PD, Humphries SE, Penney MD, Rae PW, Walker SW (1998). Simplified detection of a mutation causing familial hypercholesterolaemia throughout Britain: evidence for an origin in a common distant ancestor. ANN CLIN BIOCHEM, 35(Pt 2), 226 - 235.
    • Ye S, Humphries S, Henney A (1998). Matrix metalloproteinases: implication in vascular matrix remodelling during atherogenesis. CLIN SCI COLCH, 94(2), 103 - 110.
    • Talmud PJ, Hall S, Holleran S, Ramakrishnan R, Ginsberg HN, Humphries SE (1998). LPL promoter -93T/G transition influences fasting and postprandial plasma triglycerides response in African-Americans and Hispanics. J LIPID RES, 39(6), 1189 - 1196.
    • Humphries SE, Nicaud V, Margalef J, Tiret L, Talmud PJ (1998). Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS). ARTERIOSCLER THROMB VASC BIOL, 18(4), 526 - 534.
    • Byrne CD, Wareham NJ, Martensz ND, Humphries SE, Metcalfe JC, Grainger DJ (1998). Increased PAI activity and PAI-1 antigen occurring with an oral fat load: associations with PAI-1 genotype and plasma active TGF-beta levels. ATHEROSCLEROSIS, 140(1), 45 - 53.
    • Lee WK, Haddad L, Macleod MJ, Dorrance AM, Wilson DJ, Gaffney D, Dominiczak MH, Packard CJ, Day IN, Humphries SE, Dominiczak AF (1998). Identification of a common low density lipoprotein receptor mutation (C163Y) in the west of Scotland. Journal of Medical Genetics, 35(7), 573 - 578.
    • Gudnason V, Zhou T, Thormar K, Baehring S, Cooper J, Miller G, Humphries SE, Schuster H (1998). Detection of the low density lipoprotein receptor gene PvuII intron 15 polymorphism using the polymerase chain reaction: association with plasma lipid traits in healthy men and women. DIS MARKERS, 13(4), 209 - 220.
    • Traeger S, Mavroidis N, Kanavakis E, Drogari E, Humphries SE, Day IN, Kattamis C, Matsaniotis N (1998). Analysis of low density lipoprotein receptor gene mutations and microsatellite haplotypes in Greek FH heterozygous children: six independent ancestors account for 60% of probands. HUM GENET, 102(3), 343 - 347.
    • Wilson DJ, Gahan M, Haddad L, Heath K, Whittall RA, Williams RR, Humphries SE, Day IN (1998). A World Wide Web site for low-density lipoprotein receptor gene mutations in familial hypercholesterolemia: sequence-based, tabular, and direct submission data handling. AM J CARDIOL, 81(12), 1509 - 1511.
    • Montgomery HE, Marshall R, Hemingway H, Myerson S, Clarkson P, Dollery C, Hayward M, Holliman DE, Jubb M, World M, Thomas EL, Brynes AE, Saeed N, Barnard M, Bell JD, Prasad K, Rayson M, Talmud PJ, Humphries SE (1998). Human gene for physical performance [letter]. NATURE, 393(6682), 221 - 222.
    • Montgomery HE, Marshall R, Hemingway H, Myerson S, Clarkson P, Dollery C, Hayward M, Holliman DE, Jubb M, World M, Thomas EL, Brynes AE, Saeed N, Barnard M, Bell JD, Prasad K, Rayson M, Talmud PJ, Humphries SE (1998). Human gene for physical performance. NATURE, 393(6682), 221 - 222.
    • Flavell DM, Pineda-Torra I, Jamshidi Y, Evans D, Syvanne M, Taskinen MR, Humphries SE, Talmud PJ, Staels B (1998). Variation in the peroxisome proliferator activated receptor alpha gene is associated with plasma lipid concentrations, response to gemfibrozil and progression of atherosclerosis in coronary artery bypass graft patients.. CIRCULATION, 98(17), 532 - 532.
    • Talmud PJ, Martin SG, Humphries SE, Taskinen MR, Sturley SL, Syvanne M (1998). Genetic variation in the 3 ' flanking sequence of the alpha(1)-antitrypsin gene is associated with increased progression of atherosclerosis in the lopid coronary angiography trial (LOCAT).. CIRCULATION, 98(17), 459 - 459.
    • Webb KE, Hamsten A, Eriksson P, Humphries SE, Martin JF (1998). A C -> A polymorphism at position 6390 within intron 6 of the thrombopoietin gene is associated with myocardial infarction in young Swedish men. CIRCULATION, 98(17), 524 - 524.
    • Talmud PJ, Bujac SR, Hall S, Humphries SE, Miller GJ (1998). LPL gene: Smoking interaction in the determination of ischaemic heart disease risk. ATHEROSCLEROSIS, 141(1), 182 - 182.
    • De Stefano V, Dekou V, Nicaud V, Chasse JF, London J, Stansbie D, Humphries SE, Gudnason V (1998). Linkage disequilibrium at the cystathionine beta synthase (CBS) locus and the association between genetic variation at the CBS locus and plasma levels of homocysteine. The Ears II Group. European Atherosclerosis Research Study.. Ann Hum Genet, 62(Pt 6), 481 - 490. doi:10.1046/j.1469-1809.1998.6260481.x
    • De Stefano V, Dekou V, Nicaud V, Chasse JP, London J, Stansbie D, Humphries SE, Gudnason V, EARS II Grp (1998). Linkage disequilibrium at the cystathionine beta synthase (CBS) locus and the association between genetic variation at the CBS locus and plasma levels of homocysteine. ANN HUM GENET, 62, 481 - 490.
    • Nissen H, Day LB, Horder M, Humphries SE, Day IN (1998). Denaturing gradient gel electrophoretic analysis of codons 3456-3553 of the apolipoprotein-B gene in 106 type 11a hyperlipoproteinaemic individuals. ANN CLIN BIOCHEM, 35(Pt 1), 137 - 139.
    • O'Dell SD, Bolla MK, Miller GJ, Cooper JA, Humphries SE, Day IN (1998). W64R mutation in beta-3-adrenergic receptor gene and weight in a large population sample. INT J OBES RELAT METAB DISORD, 22(4), 377 - 379.
    • Austin MA, Talmud PJ, Luong LA, Haddad L, Day IN, Newman B, Edwards KL, Krauss RM, Humphries SE (1998). Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib-pair linkage analysis of DZ women twins. The American Journal of Human Genetics, 62(2), 406 - 419.
    • Gudnason V, Stansbie D, Scott J, Bowron A, Nicaud V, Humphries S (1998). C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations. EARS group. ATHEROSCLEROSIS, 136(2), 347 - 354.
    • Bolla MK, Miller GJ, Yellon DM, Evans A, Luc G, Cambou JP, Arveiler D, Cambien F, Latchman DS, Humphries SE, Day IN (1998). Analysis of the association of a heat shock protein70-1 gene promoter polymorphism with myocardial infarction and coronary risk traits. DIS MARKERS, 13(4), 227 - 235.
    • Sumeray MS, Montgomery HE, Humphries SE (1998). Beyond coagulation: fibrinogen as a cause of cardiovascular surgical disease. CARDIOVASC DRUGS THER, 12(3), 261 - 265.
    • De O, Haddad L, Kwiterovich PO, Jr H, S E D, I N (1998). Applicability of LDLR flanking microsatellite polymorphisms for prenatal diagnosis of homozygous state for familial hypercholesterolemia. CLIN GENET, 53(5), 375 - 378.
    • Riches FM, Watts GF, van Bockxmeer FM, Hua J, Song S, Humphries SE, Talmud PJ (1998). Apolipoprotein B signal peptide and apolipoprotein E genotypes as determinants of the hepatic secretion of VLDL apoB in obese men. J LIPID RES, 39(9), 1752 - 1758.
    • O'Dell SD, Wilson DJ, Durrington PN, Humphries SE, Day IN (1998). CpG-PCR combined with sample pooling and mutant enrichment for CpG mutation screening in population studies. CLIN CHEM, 44(1), 183 - 185.

    1997

    • Day IN, Whittall RA, O'Dell SD, Haddad L, Bolla MK, Gudnason V, Humphries SE (1997). Spectrum of LDL receptor gene mutations in heterozygous familial hypercholesterolemia. HUM MUTAT, 10(2), 116 - 127.
    • Temple A, Luong LA, Cruickshank K, Humphries SE (1997). The 10-base-pair insertion in the promoter of the factor VII gene is not associated with lower levels of factor VIIc in Afrocarribeans [letter]. THROMB HAEMOST, 77(1), 213 - 214.
    • Yudkin JS, Andres C, Mohamed A, Gould M, Panahloo A, Haines AP, Humphries S, Talmud P (1997). The angiotensin-converting enzyme gene and the angiotensin II type I receptor gene as candidate genes for microalbuminuria. A study in nondiabetic and non-insulin-dependent diabetic subjects. ARTERIOSCLER THROMB VASC BIOL, 17(10), 2188 - 2191.
    • Henry JA, Bolla M, Osmond C, Fall C, Barker DJ, Humphries SE (1997). The effects of genotype and infant weight on adult plasma levels of fibrinogen, factor VII, and LDL cholesterol are additive. Journal of Medical Genetics, 34(7), 553 - 558.
    • Heath KE, Luong LA, Leonard JV, Chester A, Shoulders CC, Scott J, Middleton P, Humphries SE, Talmud PJ (1997). The use of a highly informative CA repeat polymorphism within the abetalipoproteinaemia locus (4q22-24). PRENAT DIAGN, 17(12), 1181 - 1186.
    • Peacock RE, Temple A, Gudnason V, Rosseneu M, Humphries SE (1997). Variation at the lipoprotein lipase and apolipoprotein AI-CIII gene loci are associated with fasting lipid and lipoprotein traits in a population sample from Iceland: interaction between genotype, gender, and smoking status. GENET EPIDEMIOL, 14(3), 265 - 282.
    • Montgomery HE, Clarkson P, Dollery CM, Prasad K, Losi MM, Hemingway H, Statters D, Jubb M, Girvain M, Varnava A, World M, Deanfield J, Talmud P, McEwan JR, McKenna WJ, Humphries S (1997). Association of angiotensin converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training. Circulation, 96, 741 - 747.
    • Humphries SE, Galton D, Nicholls P (1997). Genetic testing for familial hypercholesterolaemia: practical and ethical issues. QJM, 90(3), 169 - 181.
    • Day IN, Haddad L, O'Dell SD, Day LB, Whittall RA, Humphries SE (1997). Identification of a common low density lipoprotein receptor mutation (R329X) in the south of England: complete linkage disequilibrium with an allele of microsatellite D19S394. Journal of Medical Genetics, 34(2), 111 - 116.
    • Mavroidis N, Traeger S, Kanavakis E, Drogari E, Matsaniotis N, Humphries SE, Day IN, Kattamis C (1997). A high incidence of mutations in exon 6 of the low-density lipoprotein receptor gene in Greek familial hypercholesterolemia patients, including a novel mutation. HUM MUTAT, 9(3), 274 - 276.
    • Fisher RM, Humphries SE, Talmud PJ (1997). Common variation in the lipoprotein lipase gene: effects on plasma lipids and risk of atherosclerosis.. Atherosclerosis, 135(2), 145 - 159.
    • Byrne CD, Wareham NJ, Clark PMS, Martensz ND, Humphries SE, Metcalfe JC, Grainger DJ (1997). PAI activity and PAI-1 antigen both increase during a fat tolerance test: Associations with PAI-1 genotype and TGF-beta levels. ATHEROSCLEROSIS, 135(1), 21 - 21.
    • Fisher RM, Rawesh A, Talmud PJ, Coppack SW, Humphries SE (1997). Use of an intra-venous fat tolerance test to study in vivo the effect of common mutations in the lipoprotein lipase gene. ATHEROSCLEROSIS, 135(1), 16 - 16.
    • Dollery CM, McClelland A, Latchman DS, Henney AM, Humphries SE, McEwan JR (1997). Adenoviral gene transfer of human TIMP-1 inhibits smooth muscle cell migration and neointima formation in injured rat carotid arteries..
    • Jukema JW, deMaat MP, Ye S, Zwinderman AH, Beekman M, Kastelein JJP, vanBoven AJ, Bruschke AVG, Humphries SE, Kluft C, Henney AM (1997). Risk of clinical restenosis after PTCA is influenced by a common functional variant in the human stromelysin-1 gene promoter. CIRCULATION, 96(8), 593 - 593.
    • Jones L, Seed M, Heath K, Gudnason V, Humphries SE (1997). Is there an effect of defined molecular defect on therapeutic response to HMG Co A reductase inhibitors in patients with familial hypercholesterolaemia?. ATHEROSCLEROSIS, 134(1-2), 126 - 126.
    • Talmud PJ, Hall S, Ramakrishnan S, Hollera S, Ginsberg H, Humphries SE (1997). LPL-93G promoter mutation influences both baseline plasma triglycerides and postprandial response in Black and Hispanics. ATHEROSCLEROSIS, 134(1-2), 72 - 73.
    • Fisher RM, Burke H, Nicaud V, Humphries SE (1997). No effect of apolipoprotein AIV polymorphisms T347S and Q360H on fasting and postprandial lipids in the European Atherosclerosis Research Study II. ATHEROSCLEROSIS, 134(1-2), 339 - 339.
    • Talmud PJ, Margalef J, Turner P, Tiret L, Nicaud V, Humphries SE (1997). Variation in the LPL gene is associated with plasma TG concentrations and MI in the European Atherosclerosis Research Study (EARS). ATHEROSCLEROSIS, 134(1-2), 73 - 73.
    • Webb KE, Henney AM, Anglin S, Humphries SE, McEwan JR (1997). Expression of matrix metalloproteinases and their inhibitor TIMP-1 in the rat carotid artery after balloon injury. Arteriosclerosis, Thrombosis, and Vascular Biology, 17(9), 1837 - 1844.
    • Humphries SE, Thomas A, Montgomery HE, Green F, Winder A, Miller G (1997). Gene-environment interaction in the determination of plasma levels of fibrinogen.
    • Tybjaerg H, Agerholm L, Humphries SE, Abildgaard S, Schnohr P, Nordestgaard BG (1997). A common mutation (G-455--> A) in the beta-fibrinogen promoter is an independent predictor of plasma fibrinogen, but not of ischemic heart disease. A study of 9,127 individuals based on the Copenhagen City Heart Study. J CLIN INVEST, 99(12), 3034 - 3039.
    • Hall S, Chu G, Miller G, Cruickshank K, Cooper JA, Humphries SE, Talmud PJ (1997). A common mutation in the lipoprotein lipase gene promoter, -93T/G, is associated with lower plasma triglyceride levels and increased promoter activity in vitro. ARTERIOSCLER THROMB VASC BIOL, 17(10), 1969 - 1976.
    • O'Dell SD, Miller GJ, Cooper JA, Hindmarsh PC, Pringle PJ, Ford H, Humphries SE, Day IN (1997). Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males. INT J OBES RELAT METAB DISORD, 21(9), 822 - 825.
    • Ribalta J, La Ville AE, Vallve JC, Humphries S, Turner PR, Masana L (1997). A variation in the apolipoprotein C-III gene is associated with an increased number of circulating VLDL and IDL particles in familial combined hyperlipidemia. J LIPID RES, 38(6), 1061 - 1069.
    • Powell JT, Turner RJ, Henney AM, Miller GJ, Humphries SE (1997). An association between arterial pulse pressure and variation in the fibrillin-1 gene. HEART, 78(4), 396 - 398.
    • Talmud PJ, Humphries SE (1997). Apolipoprotein C-III gene variation and dyslipidaemia. CURR OPIN LIPIDOL, 8(3), 154 - 158.
    • Gudnason V, Sigurdsson G, Nissen H, Humphries SE (1997). Common founder mutation in the LDL receptor gene causing familial hypercholesterolaemia in the Icelandic population. HUM MUTAT, 10(1), 36 - 44.
    • Syvanne M, Talmud PJ, Humphries SE, Fisher RM, Rosseneu M, Hilden H, Taskinen MR (1997). Determinants of postprandial lipemia in men with coronary artery disease and low levels of HDL cholesterol. J LIPID RES, 38(7), 1463 - 1472.
    • Haddad L, Day LB, Attwood J, Povey S, Humphries SE, Day INM (1997). Development of a microsatellite-based approach to co-segregation analysis of familial hypercholerterolaemic kindreds. ANN HUM GENET, 61, 497 - 506.
    • Mailly F, Palmen J, Muller DP, Gibbs T, Lloyd J, Brunzell J, Durrington P, Mitropoulos K, Betteridge J, Watts G, Lithell H, Angelico F, Humphries SE, Talmud PJ (1997). Familial lipoprotein lipase (LPL) deficiency: a catalogue of LPL gene mutations identified in 20 patients from the UK, Sweden, and Italy. HUM MUTAT, 10(6), 465 - 473.
    • Humphries SE, Panahloo A, Montgomery HE, Green F, Yudkin J (1997). Gene-environment interaction in the determination of levels of haemostatic variables involved in thrombosis and fibrinolysis. THROMB HAEMOST, 78(1), 457 - 461.
    • Gudnason V, Thormar K, Humphries SE (1997). Interaction of the cholesteryl ester transfer protein I405V polymorphism with alcohol consumption in smoking and non-smoking healthy men, and the effect on plasma HDL cholesterol and apoAI concentration. CLIN GENET, 51(1), 15 - 21.
    • Gerdes C, Fisher RM, Nicaud V, Boer J, Humphries SE, Talmud PJ, Faergeman O (1997). Lipoprotein lipase variants D9N and N291S are associated with increased plasma triglyceride and lower high-density lipoprotein cholesterol concentrations: studies in the fasting and postprandial states: the European Atherosclerosis Research Studies. CIRCULATION, 96(3), 733 - 740.
    • Humphries SE, Gudnason V, Whittall R, Day IN (1997). Single-strand conformation polymorphism analysis with high throughput modifications, and its use in mutation detection in familial hypercholesterolemia. International Federation of Clinical Chemistry Scientific Division: Committee on Molecular Biology Tec. CLIN CHEM, 43(3), 427 - 435.

    1996

    • Montgomery HE, Clarkson P, Nwose OM, Mikailidis DP, Jagroop IA, Dollery C, Moult J, Benhizia F, Deanfield J, Jubb M, World M, McEwan JR, Winder A, Humphries S (1996). The acute rise in plasma fibrinogen concentration with exercise is influenced by the G-453-A polymorphism of the beta-fibrinogen gene. ARTERIOSCLER THROMB VASC BIOL, 16(3), 386 - 391.
    • Saha N, Talmud PJ, Tay JSH, Humphries SE, Basair J (1996). Lack of association of angiotensin-converting enzyme (ACE). Gene insertion/deletion polymorphism with CAD in two Asian populations. CLIN GENET, 50(3), 121 - 125.
    • Humphries SE, Talmud PJ, Cox C, Sutherland W, Mann J (1996). Genetic factors affecting the consistency and magnitude of changes in plasma cholesterol in response to dietary challenge.. QJM, 89(9), 671 - 680.
    • Talmud PJ, Hall S, Chu G, Ginsberg HN, Ramakrishnan R, Miller G, Humphries SE (1996). Lipoprotein lipase -93T/G transition is associated with lower plasma triglyceride levels and increases promoter activity in vitro. CIRCULATION, 94(8), 1587 - 1587.
    • TybjaergHansen A, Reeler S, AgerholmLarsen B, Humphries SE, Schnohr P, Nordestgaard BG (1996). A mutation in the beta-fibrinogen promoter raises plasma fibrinogen, an independent risk factor for ischemic heart disease in men and women in the Copenhagen City Heart Study. CIRCULATION, 94(8), 4337 - 4337.
    • Byrne CD, Wareham NJ, Mistry PK, Phillips DIW, Martensz ND, Halsall D, Talmud PJ, Humphries SE, Hales CN (1996). The association between free fatty acid concentrations and triglyceride-rich lipoproteins in the post-prandial state is altered by a common deletion polymorphism of the apo B signal peptide. ATHEROSCLEROSIS, 127(1), 35 - 42.
    • Day IN, Bolla M, Haddad L, O'Dell S, Humphries SE (1996). Microtiter Array Diagonal Gel Electrophoresis (MADGE) for Population Scale Genotype Analyses.. Methods Mol Med, 5, 269 - 281. doi:10.1385/0-89603-346-5:269
    • Humphries SE, Gudnason V, Whittall RE, Day IN (1996). High throughput modifications of single-strand conformation polymorphism analysis : mutation detection in familial hypercholesterolemia.. Methods Mol Med, 5, 321 - 340. doi:10.1385/0-89603-346-5:321
    • Mailly F, Fisher RM, Nicaud V, Luong LA, Evans AE, Marques-Vidal P, Luc G, Arveiler D, Bard JM, Poirier O, Talmud PJ, Humphries SE (1996). Association between the LPL-D9N mutation in the lipoprotein lipase gene and plasma lipid traits in myocardial infarction survivors from the ECTIM Study.. Atherosclerosis, 122(1), 21 - 28.
    • Ye S, Eriksson P, Hamsten A, Kurkinen M, Humphries SE, Henney AM (1996). Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression.. J Biol Chem, 271(22), 13055 - 13060.
    • O'Dell SD, Humphries SE, Day IN (1996). PCR induction of a TaqI restriction site at any CpG dinucleotide using two mismatched primers (CpG-PCR).. Genome Res, 6(6), 558 - 568.
    • Talmud PJ, Tamplin OJ, Heath K, Gaffney D, Day INM, Humphries SE (1996). Rapid testing for three mutations causing familial defective apolipoprotein B100 in 562 patients with familial hypercholesterolaemia. ATHEROSCLEROSIS, 125(1), 135 - 137.

    1995

    • Fisher RM, Mailly F, Peacock RE, Hamsten A, Seed M, Yudkin JS, Beisiegel U, Feussner G, Miller G, Humphries SE, et AL (1995). Interaction of the lipoprotein lipase asparagine 291-->serine mutation with body mass index determines elevated plasma triacylglycerol concentrations: a study in hyperlipidemic subjects, myocardial infarction survivors, and healthy adults.. The Journal of Lipid Research, 36(10), 2104 - 2112.
    • Panahloo A, Andres C, Mohamed-Ali V, Gould MM, Talmud P, Humphries SE, Yudkin JS (1995). The insertion allele of the ACE gene I/D polymorphism. A candidate gene for insulin resistance?. Circulation, 92(12), 3390 - 3393.
    • Panahloo A, Mohamed-Ali V, Lane A, Green F, Humphries SE, Yudkin JS (1995). Determinants of plasminogen activator inhibitor 1 activity in treated NIDDM and its relation to a polymorphism in the plasminogen activator inhibitor 1 gene.. Diabetes, 44(1), 37 - 42.
    • Humphries SE, Talmud PJ (1995). Hyperlipidaemia associated with genetic variation in the apolipoprotein B gene.. Curr Opin Lipidol, 6(4), 215 - 222.
    • Day IN, O'Dell SD, Cash ID, Humphries SE, Weavind GP (1995). Electrophoresis for genotyping: temporal thermal gradient gel electrophoresis for profiling of oligonucleotide dissociation.. Nucleic Acids Res, 23(13), 2404 - 2412.
    • Peacock RE, Karpe F, Talmud PJ, Hamsten A, Humphries SE (1995). Common variation in the gene for apolipoprotein B modulates postprandial lipoprotein metabolism: a hypothesis generating study.. Atherosclerosis, 116(1), 135 - 145.
    • Day IN, Whittall R, Gudnason V, Humphries SE (1995). Dried template DNA, dried PCR oligonucleotides and mailing in 96-well plates: LDL receptor gene mutation screening.. Biotechniques, 18(6), 981 - 984.
    • MONTGOMERY HE, KEELING PJ, GOLDMAN JH, HUMPHRIES SE, TALMUD PJ, MCKENNA WJ (1995). LACK OF ASSOCIATION BETWEEN THE INSERTION DELETION POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING ENZYME GENE AND IDIOPATHIC DILATED CARDIOMYOPATHY. J AM COLL CARDIOL, 25(7), 1627 - 1631.
    • O'Dell SD, Humphries SE, Day IN (1995). Rapid methods for population-scale analysis for gene polymorphisms: the ACE gene as an example.. Br Heart J, 73(4), 368 - 371.
    • Humphries SE (1995). Genetic regulation of fibrinogen.. Eur Heart J, 16 Suppl A, 16 - 19.
    • Ye S, Watts GF, Mandalia S, Humphries SE, Henney AM (1995). Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis.. Br Heart J, 73(3), 209 - 215.
    • Gudnason V, Muller DPR, Lloyd JK, Humphries SE (1995). Response to drugs and diet in a compound heterozygote for familial hypercholesterolaemia. ARCH DIS CHILD, 73(6), 538 - 540.
    • Day IN, Humphries SE, Richards S, Norton D, Reid M (1995). High-throughput genotyping using horizontal polyacrylamide gels with wells arranged for microplate array diagonal gel electrophoresis (MADGE).. Biotechniques, 19(5), 830 - 835.
    • BOLLA MK, HADDAD L, HUMPHRIES SE, WINDER AF, DAY INM (1995). HIGH-THROUGHPUT METHOD FOR DETERMINATION OF APOLIPOPROTEIN-E GENOTYPES WITH USE OF RESTRICTION DIGESTION ANALYSIS BY MICROPLATE ARRAY DIAGONAL GEL-ELECTROPHORESIS. CLIN CHEM, 41(11), 1599 - 1604.
    • Ye S, Green FR, Scarabin PY, Nicaud V, Bara L, Dawson SJ, Humphries SE, Evans A, Luc G, Cambou JP (1995). The 4G/5G genetic polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene is associated with differences in plasma PAI-1 activity but not with risk of myocardial infarction in the ECTIM study. Etude CasTemoins de I'nfarctus du Mycocarde.. Thromb Haemost, 74(3), 837 - 841.
    • Humphries SE, Peacock RE, Talmud PJ (1995). The genetic determinants of plasma cholesterol and response to diet.. Baillieres Clin Endocrinol Metab, 9(4), 797 - 823.

    1994

    • Day IN, Humphries SE (1994). Electrophoresis for genotyping: microtiter array diagonal gel electrophoresis on horizontal polyacrylamide gels, hydrolink, or agarose.. Anal Biochem, 222(2), 389 - 395. doi:10.1006/abio.1994.1507
    • SAHA N, TAY JSH, LOW PS, HUMPHRIES SE (1994). GUANIDINE TO ADENINE (G/A) SUBSTITUTION IN THE PROMOTER REGION OF THE APOLIPOPROTEIN AI GENE IS ASSOCIATED WITH ELEVATED SERUM APOLIPOPROTEIN AI LEVELS IN CHINESE NONSMOKERS. GENET EPIDEMIOL, 11(3), 255 - 264.
    • STURLEY SL, TALMUD PJ, BRASSEUR R, CULBERTSON MR, HUMPHRIES SE, ATTIE AD (1994). HUMAN APOLIPOPROTEIN-B SIGNAL SEQUENCE VARIANTS CONFER A SECRETION-DEFECTIVE PHENOTYPE WHEN EXPRESSED IN YEAST. J BIOL CHEM, 269(34), 21670 - 21675.
    • Talmud PJ, Ye S, Humphries SE (1994). Polymorphism in the promoter region of the apolipoprotein AI gene associated with differences in apolipoprotein AI levels: the European Atherosclerosis Research Study.. Genet Epidemiol, 11(3), 265 - 280. doi:10.1002/gepi.1370110305
    • SEED M, MAILLY F, VALLANCE D, DOHERTY E, WINDER A, TALMUD P, HUMPHRIES SE (1994). LIPOPROTEIN-LIPASE ACTIVITY IN PATIENTS WITH COMBINED HYPERLIPEMIA. CLIN INVESTIGATOR, 72(2), 100 - 106.
    • Laywood A, Whittall R, Gudnason V, Humphries SE, Day IN (1994). Handling of large (300 x 400 mm), thin (0.4 mm) polyacrylamide gels and recovery as dried gels.. Biotechniques, 17(5), 850 - 854.
    • HUMPHRIES SE (1994). THE GENETIC CONTRIBUTION TO THE RISK OF THROMBOSIS AND CARDIOVASCULAR-DISEASE. TRENDS CARDIOVAS MED, 4(1), 8 - 17.
    • Humphries SE, Lane A, Green FR, Cooper J, Miller GJ (1994). Factor VII coagulant activity and antigen levels in healthy men are determined by interaction between factor VII genotype and plasma triglyceride concentration.. Arterioscler Thromb, 14(2), 193 - 198.
    • Talmud PJ, Krul ES, Pessah M, Gay G, Schonfeld G, Humphries SE, Infante R (1994). Donor splice mutation generates a lipid-associated apolipoprotein B-27.6 in a patient with homozygous hypobetalipoproteinemia.. J Lipid Res, 35(3), 468 - 477.

    1993

    • TAN K, BETTERIDGE DJ, MARMOT MG, TALMUD P, HUMPHRIES SE, YUDKIN JS (1993). HYPERTRIGLYCERIDEMIA AND VASCULAR RISK - REPORT OF A MEETING OF PHYSICIANS AND SCIENTISTS, UNIVERSITY-COLLEGE-LONDON MEDICAL-SCHOOL. LANCET, 342(8874), 781 - 787.
    • Foster K, Ferrell R, King-Underwood L, Povey S, Attwood J, Rennick R, Humphries SE, Henney AM (1993). Description of a dinucleotide repeat polymorphism in the human elastin gene and its use to confirm assignment of the gene to chromosome 7.. Ann Hum Genet, 57(Pt 2), 87 - 96.

    • Talmud PJ, Hingorani AD, Cooper JA, Marmot MG, Brunner EJ, Kumari M, Kivimäki M, Humphries SE (). Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.. British Medical Journal, , - .
    • Woo P, Humphries SE, Faulds G, Montgomery HE, Mohammed V, Fishman D, Hamsten A, Miller G, Yudkin J (). Gene-environment interaction in the determination of plasma and vessel wall cardiovascular risk factors.
    • Gertow K, Sennblad B, Strawbridge R, Ohrvik J, Zabeneh D, Shah S, Veglia F, Fava C, Kavousi M, Kivimaki M, Bolton J, Fokersen L, Gigante B, Leander K, Vikstrom M, Larsson , Silveira A, Deanfield J, Voight BF, Fontanillas P, Sabater-Lleal M, Colombo G, Kumari M, Langenberg C, Wareham N, Uitterlinder A, Gabrielsen A, Hedin U, Franco-Cereceda A, Nyyssoen K, Rauramaa R, Tuomainen T, Savonen K, Smit A, Giral P, Mannarino E, Robertson C, Talmud PJ, Hedblad B, Hofman A, Erdmann J, Reilly MP, Grazia Franzosi MG, Seedorf U, Syvanen AC, Hansson GK, Eriksson P, Samani NJ, Watkins H, Price JF, Hingorani AD, Melander O, Witterman JCM, Baldassaree D, Tremoli E, de Faire U, Hamsten A, Humphries SE (). Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-medial thickness and coronary artery disease. Circulation: Cardiovascular Genetics, , - .
    • Talmud PJ, Shah S, Futema M, Howard P, Cooper JA, Harrison SC, Li KW, Karpe F, Neil HAW, on behalf of Simon Broome Registry Group , Langenberg C, Lench N, Kivimaki M, Hingorani AD, Kumari M (). Familial hypercholesterolaemia: a monogenic and polygenic disorder?. Lancet, , - .
    • Vaessen SF, Schaap FG, Kuivenhoven JA, Groen AK, Hutten BA, Boekholdt SM, Hattori H, Sandhu MS, Bingham SA, Luben R, Palmen JA, Wareham NJ, Humphries SE, Kastelein JJ, Talmud PJ, Khaw KT (). Apolipoprotein av, triglycerides and risk of future coronary artery disease in apparently healthy men and women; the prospective epic-norfolk population study.. The Journal of Lipid Research, , - .
    • Nibali L, D'Aiuto F, Donos N, Griffiths G, Parkar M, Tonetti M, Humphries S, Brett P (). Association between periodontitis and common Variants in the promoter of the Interleukin-6 gene Corresponding Author. Cytokine, , - .
    • Harrison SC, Smith AJP, Jones GT, Swerdlow DI, Rampuri R, Bown MK, Folkersen L, Baas AF, de Borst GJ, Blankensteijn JD, Price JF, van der Graaf Y, McLachlan S, Agu O, Hofman A, Uitterlinden AG, Franco-Cereceda A, Ruigrok YM, Van't Hof FN, Powell JT, van Rij AM, Casas JP, Eriksson P, Holmes MV, Asselbergs FW, Hingorani AD, Humphries SE (). Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1.. European Heart Journal, , - .