Prof Humphrey Hodgson

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Name: Humphrey Hodgson Email: h.hodgson@ucl.ac.uk
Title: Prof Tel:
Department: Div of Medicine Fax:
Position: Honorary Emeritus Address: , , ,
Research Domain: Basic Life Sciences, Experimental Medicine, Infection Immunology & Inflammation Web Page:  

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Research Description

Professor Humphrey Hodgson Sheila Sherlock Professor of Medicine Director of the Centre for Hepatology Vice-Dean and Campus Director Personal Details: Royal Free and University College Medical School ( University College London ) Hampstead Campus Centre for Hepatology, Department of Medicine Rowland Hill Street London NW3 2PF UK Phone: Fax: Email: +44 (0)20 7433 2850/1 +44 (0)20 7433 2852 h.hodgson@medsch.ucl.ac.uk Career Details: 1999-present: UCL Director of the Centre for Hepatology, Royal Free and University College Medical School Past appointments 1996-1999 Imperial College School of Medicine, London Professor of Medicine/Honorary Consultant Physician Hammersmith Hospital , London 1992-1995 Professor of Gastroenterology/Honorary Consultant Physician, Royal Postgraduate Medical School 1987-1991 Reader in Gastroenterology/Consultant Physician, Royal Postgraduate Medical School Hammersmith Hospital , London Qualifications B.A., Oxon, Animal Physiology (First Class) 1966, B.Sc., Oxon 1969 B.M., B.Ch., Oxon 1970, M.A., Oxon 1970, M.R.C.P., (UK) 1972 D.M., Oxon 1977, F.R.C.P. 1983 F Med Sci 2002 Research Interests: Exploiting liver cell biology for therapeutic ends. Current projects involve: * In vivo gene transfer to hepatocytes in animals, in particular using growth factors to induce hepatocyte DNA synthesis in intact liver to allow retroviral gene transfer * Use of growth factors to enhance size and function of intact liver in vitro, in particular investigating efficacy and mechanism of tri-iodothyronine as a primary mitogen * Identification of toxic factors in liver failure plasma * Development of liver cell culture techniques to provide biological component of a bio-artificial liver device * Investigation of pathophysiology of inflammatory disease affecting liver and gut.

Research Activities

Education Description

UCL Collaborators

External Collaborators

Publications

    2007

    • Selden C, Mellor N, Rees M, Laurson J, Kirwan M, Escors D, Collins M, Hodgson H (2007). Growth factors improve gene expression after lentiviral transduction in human adult and fetal hepatocytes. J Gene Med., 9(2), 67 - 76. doi:10.1002/jgm.1000
    • Mavri-Damelin D, Eaton S, Damelin LH, Rees M, Hodgson HJ, Selden C (2007). Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2. Int.J Biochem.Cell Biol., 39(3), 555 - 564. doi:10.1016/j.biocel.2006.10.007
    • Damelin LH, Coward S, Kirwan M, Collins P, Selden C, Hodgson HJ (2007). Fat-loaded HepG2 spheroids exhibit enhanced protection from Pro-oxidant and cytokine induced damage. J Cell Biochem., 101(3), 723 - 734.

    2005

    • Saich R, Collins P, Ala A, Standish R, Hodgson H (2005). Benign recurrent intrahepatic cholestasis with secondary renal impairment treated with extracorporeal albumin dialysis.. European Journal of Gastroenterology and Hepatology, 17(5), 585 - 588.
    • Malik R, Habib M, Tootle R, Hodgson H (2005). Exogenous thryoid hormone induces liver enlargement, whilst maintaining regenerative potential: a study relevant to donor preconditioning.. American Journal of Transplantation, 5(8), 1801 - 1807. doi:10.1111/j.1600-6143.2005.00949.x
    • Laurson J, Selden C, Hodgson HJ (2005). Hepatocyte progenitors in man and in rodents-multiple pathways, multiple candidates.. Int J Exp Pathol., 86(1), 1 - 18.
    • Rahman TM, Diakanov I, Selden C, Hodgson H (2005). Co-transplantation of encapsulated HepG2 and rat Sertoli cells improves outcome in a thioacetamide induced rat model of acute hepatic failure.. Transplant International, 18(8), 1001 - 1009. doi:10.1111/j.1432-2277.2005.00156.x
    • Habib MM, Selden C, Hodgson HFJ, Davidson BR (2005). Regeneration of the ischaemic liver remnant and effect of glycine.
    • Malik R, Bungay A, Riemann M, Schmid R, Brown D, Hubank M, Selden C, Hodgson H (2005). Stimulation of hepatocyte proliferation and liver growth by triodothyronine (T3) and it's relationship to Bcl-3 expression.
    • Hodgson H (2005). c-met—there when it's needed?. Journal of Hepatology, 43(3), 544 - 546.
    • Collins P, Jones C, Choudhury S, Damelin L, Hodgson H (2005). Increased expression of uncoupling protein 2 in HepG2 cells attenuates oxidative damage and apoptosis.. Liver International, 25(4), 880 - 7.
    • Habib MM, Selden C, Hodgson HFJ, Davidson BR (2005). Transient ischaemia and reperfusion impairs early regenerative response in the hepatic remnant.
    • Coward SM, Selden C, Mantalaris A, Hodgson HJ (2005). Proliferation rates of HepG2 cells encapsulated in alginate are increased in a microgravity environment compared with static cultures.. Artificial Organs, 29(2), 152 - 158.

    2004

    • Rahman TM, Selden C, Khalil M, Diakanov I, Hodgson HJ (2004). Alginate-encapsulated human hepatoblastoma cells in an extracorporeal perfusion system improve some systemic parameters of liver failure in a xenogeneic model.. Artificial Organs, 28(5), 476 - 482.
    • Mellor N, Themis M, Selden C, Jones M, Hodgson HJ (2004). Characteristics of murine histidinaemia and its potential for genetic manipulation.. Liver International, 24(4), 354 - 360.
    • Craig CE, Quaglia A, Selden C, Lowdell M, Hodgson H, Dhillon A (2004). The histopathology of regeneration in massive hepatic necrosis. SEMINARS IN LIVER DISEASE, 24(1), 49 - 64.
    • Selden C, Hodgson H (2004). Cellular therapies for liver replacement.. Transplant Immunology, 12(3), 273 - 288.
    • Damelin LH, Coward S, Choudhury SF, Chalmers SA, Cox IJ, Robertson NJ, Revial G, Miles M, Tootle R, Hodgson HJ, Selden C (2004). Altered mitochondrial function and cholesterol synthesis influences protein synthesis in extended HepG2 spheroid cultures.. Archives of Biochemistry and Biophysics, 432(2), 167 - 177.
    • Lindsay JO, Sandison A, Cohen P, Brennan FM, Hodgson HJ (2004). IL-10 gene therapy is therapeutic for dextran sodium sulfate-induced murine colitis.. Digestive Diseases and Sciences, 49(7), 1327 - 1334.

    2003

    • Ala A, Brown D, Stubbs M, Jacobs R, Hodgson H (2003). Mucosal cell adhesion molecule (MAdCAM-1) expression in chronic liver disease and development of an in vitro model to investigate therapeutic modulation.
    • Hodgson H (2003). Liver cells: biology to therapeutics. Clinical Medicine, 3(2), 161 - 165.
    • Lindsay JO, Ciesielski CJ, Scheinin T, Brennan FM, Hodgson HJ (2003). Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis. Gut, 52(7), 981 - 987.
    • Craig CEH, Quaglia A, Savage K, Lowdell MW, Selden C, Sim R, North J, Prentice HG, Hodgson H, Dhillon AP (2003). Hepatocyte progenitor cells in massive hepatic necrosis.
    • Malik R, Khan K, Rahma T, Hodgson H (2003). Mitogenic therapy administered after the induction of liver failure enhances the proliferative response of hepatocytes within the failing organ.
    • Alsowmely A, Grasso A, Hodgson H, Burroughs A, Davidson B, Quaglia A, Dhillon A, Rolles K (2003). Life-table analysis of survival after liver transplantation for hepatocellular carcinoma: A single centre study.
    • Ala A, Dhillon AP, Hodgson HJ (2003). Role of cell adhesion molecules in leukocyte recruitment in the liver and gut. International Journal of Experimental Pathology, 84(1), 1 - 16.
    • Lindsay JO, Ciesielski CJ, Scheinin T, Brennan FM, Hodgson HJ (2003). Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis. Gut, 52(3), 363 - 369. doi:10.1136/gut.52.3.363
    • Selden AC, Chalmers SA, Jones C, Standish R, Quaglia A, Rolando N, Burroughs AK, Rolles K, Dhillon AP, Hodgson HJF (2003). Epithelial colonies cultured from human explanted liver in subacute hepatic failure exhibit hepatocyte, biliary epithelial, and stem cell phenotypic markers. Stem Cells, 21(6), 624 - 631. doi:10.1634/stemcells.21-6-624
    • Selden C, Casbard A, Themis M, Hodgson HJ (2003). Characterization of long-term survival of syngeneic hepatocytes in rat peritoneum. Cell Transplantation, 12(6), 569 - 578.
    • Craig CEH, Quaglia A, Savage K, Lowdell MW, Seldon C, Sim R, North J, Prentice HG, Hodgson H, Dhillon AP (2003). Hepatocyte progenitor cells in massive hepatic necrosis.
    • Malik R, Mellor N, Selden C, Hodgson H (2003). Triiodothyronine enhances the regenerative capacity of the liver following partial hepatectomy. Hepatology, 37(1), 79 - 86. doi:10.1053/jhep.2003.50001
    • Rahman TM, Hodgson HJF (2003). The effects of early and late administration of inhibitors of inducible nitric oxide synthase in a thioacetamide-induced model of acute hepatic failure in the rat. Journal of Hepatology, 38(5), 583 - 590. doi:10.1016/S0168-8278(03)00050-3

    2002

    • Alsowmely AM, Hodgson HJ (2002). Non-surgical treatment of hepatocellular carcinoma. Alimentary Pharmacology and Therapeutics, 16(1), 1 - 15.
    • Rahman TM, Selden AC, Hodgson HJ (2002). A novel model of acetaminophen-induced acute hepatic failure in rabbits. Journal Of Surgical Research, 106(2), 264 - 272.
    • Hodgson H, Rahman TM, Selden C (2002). Co-transplantation of hepatocytes and non-parenchymal cells. Hepatocyte Transplantation. In Gupta S, Jansen P, Klempnauer J, Manns M (Ed.), (pp. 51 - 59). : Kluwer Ac Publishers.
    • Hodgson HJF (2002). Biomarkers in gastrointestinal disease. In Trull A, Demers L, Holt D, Johnston A, Tredger JM (Ed.), Biomarkers of Disease: An Evidence-Based Approach (pp. 265 - 271). : Cambridge University Press.
    • Hodgson H (2002). Sheila Sherlock's legacy. The Lancet, 359(9305), 460 - .
    • Alsowmely AM, Hodgson HJF (2002). Review article: non-surgical treatment of hepatocellular carcinoma. Alimentary Pharmacology and Therapeutics, 16(1), 1 - 15.
    • Malik R, Hodgson H (2002). The relationship between the thyroid gland and the liver. QJM, 95(9), 559 - 569.
    • Selden C, Hodgson HJF (2002). Engineering the liver. In Polak JM, Hench L, Kemp P (Ed.), Future strategies for tissue and organ replacement (pp. 141 - 182). : Imperial College Press.
    • Hodgson H (2002). Hormonal therapy for gastrointestinal angiodysplasia. The Lancet, 359(9318), 1630 - 1631.
    • Ala A, Standish R, Khan K, Stubbs M, Hillan K, Dhillon AP, Hodgson HJF (2002). Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and podoplanin localisation in primary sclerosing cholangitis (PSC) & primary biliary cirrhosis (PBC). Gut, 50, 202 - .
    • McCloskey P, Tootle R, Selden C, Larsen F, Roberts E, Hodgson HJ (2002). Modulation of hepatocyte function in an immortalized human hepatocyte cell line following exposure to liver-failure plasma. Artificial Organs, 26(4), 340 - 348.
    • Hodgson HJF (2002). Carcinoid tumours and the carcinoid syndrome. In Wass JAH, Shalet SM (Ed.), Oxford Textbook of Endocrinology and Diabetes (pp. 871 - 876). : .
    • Lindsay J, Van Montfrans C, Brennan F, Van Deventer S, Drillenburg P, Hodgson H, Te VA, Sol Rodriguez PM (2002). IL-10 gene therapy prevents TNBS-induced colitis. Gene Therapy, 9(24), 1715 - 1721.
    • Malik R, Selden C, Hodgson H (2002). The role of non-parenchymal cells in liver growth. Seminars in Cell and Developmental Biology, 13(6), 425 - 431.
    • Ala A, Standish R, Khan K, Hillan K, Dhillon A, Hodgson H (2002). Podoplanin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) localisation in primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Journal of Hepatology, 36, 501 - .

    2001

    • Ala A, Standish R, Khan K, Prasad N, Hillan K, Dhillon AP, Hodgson H (2001). Immmunohistochemical study of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) expression in primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Hepatology, 34(4), 1404 - .
    • Khalil M, Shariat-Panahi A, Tootle R, Ryder T, McCloskey P, Roberts E, Hodgson H, Selden C (2001). Human hepatocyte cell lines proliferating as cohesive spheroid colonies in alginate markedly upregulate both synthetic and detoxificatory liver function. Journal of Hepatology, 34(1), 68 - 77. doi:10.1016/S0168-8278(00)00080-5
    • Rahman T, Hodgson H (2001). Clinical management of acute hepatic failure. Intensive Care Medicine, 27(3), 467 - 476.
    • Lindsay JO, Hodgson HJ (2001). Review article: the immunoregulatory cytokine interleukin-10--a therapy for Crohn's disease?. Alimentary Pharmacology and Therapeutics, 15(11), 1709 - 1716.
    • Elsheikh M, Hodgson HJ, Wass JA, Conway GS (2001). Hormone replacement therapy may improve hepatic function in women with Turner's syndrome. Clinical Endocrinology, 55(2), 227 - 231.
    • (2001). Immortalization of human hepatocytes by temperature-sensitive SV40 large-T antigen. In Vitro Cellular and Developmental Biology - Animal, 37(3), 166 - 168.
    • Gordon FH, Watkinson A, Hodgson H (2001). Vascular malformations of the gastrointestinal tract. Best Practice and Research Clinical Gastroenterology, 15(1), 41 - 58.
    • Lindsay JO, Ciesielski CJ, Scheinin T, Hodgson HJ, Brennan FM (2001). The prevention and treatment of murine colitis using gene therapy with adenoviral vectors encoding IL-10. The Journal of Immunology, 166(12), 7625 - 7633.

    2000

    • Khalil M, Hodgson HJF, Ryder T, Selden C (2000). Enhancement of proliferation and function in 3-D spheroids of human hepatocyte cell lines by human extracellular matrix, but not chemical differentiating agents.
    • Rahman TM, Hodgson HJF (2000). Artificial liver support - [double prime] Bridge to transplantation? [double prime]. Clinical Intensive Care, 11(5), 227 - 237.
    • Selden C, Khalil M, Hodgson HJF (2000). Three dimensional culture upregulates extracellular matrix protein expression in human liver cell lines: A step towards mimicking the liver in vivo?. International Journal of Artificial Organs, 23(8), 535 - .
    • Forbes SJ, Themis M, Alison MR, Shiota A, Kobayashi T, Coutelle C, Hodgson HJF (2000). Tri-iodothyronine and a deleted form of hepatocyte growth factor act synergistically to enhance liver proliferation and enable in vivo retroviral gene transfer via the peripheral venous system. Gene Therapy, 7(9), 784 - 789.
    • Hodgson HJF (2000). Azathioprine: effectiveness, action and use. In Modigliani R (Ed.), Inflammatory Bowel Disease (pp. 46 - ). : John Libbey Eurotext.
    • Mellor N, Themis M, Selden C, Jones M, Hodgson HJ (2000). Amelioration of murine histidinaemia using retroviral gene transfer.
    • Rahman TM, Hodgson HJF (2000). L-NAME and aminoguanidine (AMG): Selectivity and temporal differences in iNOS inhibition in a rat model of acute hepatic failure (AHF). Hepatology, 32(4 Pt 2), 395A - .
    • Hodgson HJF (2000). Whipple's disease. (Trophyrema Whippelii Infection). In Ledingham JGG, Warrell DA (Ed.), Concise Oxford Textbook of Medicine (pp. 554 - 555). : Oxford University Press.
    • McCloskey PG, Tootle RA, Larsen S, Selden C, Roberts E, Hodgson HJF (2000). Modulation of hepatocyte function in a hepatocyte cell line following exposure to liver failure plasma.
    • Hodgson HJF (2000). Short Gut Syndrome. In Ledingham JGG, Warrell DA (Ed.), Concise Oxford Textbook of Medicine (pp. 555 - 556). : Oxford University Press.
    • Selden C, Khalil M, Hodgson H (2000). Three dimensional culture upregulates extracellular matrix protein expression in human liver cell lines--a step towards mimicking the liver in vivo?. International Journal of Artificial Organs, 23(11), 774 - 781.
    • Rahman TM, Hodgson HJF (2000). Low dose pentoxifylline (PTX) reduces mortality in a thioacetamide induced rat model of acute hepatic failure (AHF). Hepatology, 32(4 Pt 2), 395A - .
    • Forbes SJ, Themis M, Alison MR, Sarosi I, Coutelle C, Hodgson HJF (2000). Synergistic growth factors enhance rat liver proliferation and enable retroviral gene transfer via a peripheral vein. Gastroenterology, 118(3), 591 - 598.
    • Rahman TM, Hodgson HJ (2000). Animal models of acute hepatic failure. International Journal of Experimental Pathology, 81(2), 145 - 157.
    • McCloskey PG, Selden C, Roberts E, Hodgson HJF (2000). Inhibition of tert-butylhydroperoxide (t-BH) induced oxidative stress in three human hepatocyte cell lines by pretreatment with 1,2:5,6- Dibenzylanthracence (DBA).