Dr Simon Eaton

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Personal Profile

Name: Simon Eaton Email: s.eaton@ucl.ac.uk
Title: Dr Tel: 2079052158
Department: ICH Development Bio & Cancer Prog Fax: 2074046181
Position: Senior Lecturer Address: Institute of Child Health, 30 Guilford Street, London, WC1N 1EH
Research Domain: Personalised Medicine, Populations & Lifelong Health, Reproduction & Development Web Page: Personal Web Page

Profile

Research Description

My current research interests are centred on the biochemical and metabolic responses to surgery and critical illness in infants and children. To these ends, we have established an active research group in the Paediatric Surgery unit undertaking a variety of basic science and applied clinical investigations. Recently, we have run several multi-centre and single-centre randomised clinical trials in Paediatric Surgery. I have also established a stable-isotope facility in the Institute of Child Health to undertake nutritional and body composition studies.

Research Activities

Better understand normal and abnormal development of the neuromuscular components of the gastrointestinal tract.

Development of novel stem cell-based therapies for aganglionic gut disorders

Development of the enteric neuromusculature

Novel therapies for gut disorders/diseases

Education Description

UCL Collaborators

Dr Suwan Jayasinghe; Dr Richard Day; Dr Paolo De Coppi; Dr Steven Howe; Dr Nikhil Thapar; Dr Alan Burns

External Collaborators

Publications

    2014

    • Maghsoudlou P, Tyraskis A, Urbani L, Tommasini F, Alvarez M, Eaton S, De Coppi P (2014). A comparison of three techniques of decellularizing large skeletal muscle using an intravascular approach. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 452 - 452.
    • Svensson JF, Patkova B, Almström M, Naji H, Hall NJ, Eaton S, Pierro A, Wester T (2014). Nonoperative Treatment With Antibiotics Versus Surgery for Acute Nonperforated Appendicitis in Children: A Pilot Randomized Controlled Trial.. Ann Surg, , - . doi:10.1097/SLA.0000000000000835
    • Aldeiri B, Eaton S, Lombard R, Curry J, Hill S, Huertas-Ceballos A (2014). PC.70 Signs of feed intolerance in the premature infant: is it functional dysmotility or necrotizing enterocolitis (NEC)?. Arch Dis Child Fetal Neonatal Ed, 99 Suppl 1, A60 - . doi:10.1136/archdischild-2014-306576.171
    • Maghsoudlou P, Urbani L, Milan A, Tommasini F, Eaton S, De Coppi P (2014). PFM.57 Decellularization using the detergent enzymatic treatment creates a scaffold that preserves oesophageal microarchitecture.. Arch Dis Child Fetal Neonatal Ed, 99 Suppl 1, A101 - . doi:10.1136/archdischild-2014-306576.287
    • Maghsoudlou P, Eaton S, De Coppi P (2014). Tissue engineering of the esophagus.. Semin Pediatr Surg, 23(3), 127 - 134. doi:10.1053/j.sempedsurg.2014.04.003
    • Hall NJ, Eaton S, Seims A, Leys CM, Densmore JC, Calkins CM, Ostlie DJ, St Peter SD, Azizkhan RG, von Allmen D, Langer JC, Lapidus-Krol E, Bouchard S, Piché N, Bruch S, Drongowski R, MacKinlay GA, Clark C, Pierro A (2014). Risk of incomplete pyloromyotomy and mucosal perforation in open and laparoscopic pyloromyotomy.. J Pediatr Surg, 49(7), 1083 - 1086. doi:10.1016/j.jpedsurg.2013.10.014
    • Zani A, Cananzi M, Fascetti-Leon F, Lauriti G, Smith VV, Bollini S, Ghionzoli M, D'Arrigo A, Pozzobon M, Piccoli M, Hicks A, Wells J, Siow B, Sebire NJ, Bishop C, Leon A, Atala A, Lythgoe MF, Pierro A, Eaton S, De Coppi P (2014). Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism.. Gut, 63(2), 300 - 309. doi:10.1136/gutjnl-2012-303735
    • Carnaghan H, Pereira S, James CP, Charlesworth PB, Ghionzoli M, Mohamed E, Cross KM, Kiely E, Patel S, Desai A, Nicolaides K, Curry JI, Ade-Ajayi N, De Coppi P, Davenport M, David AL, Pierro A, Eaton S (2014). Is early delivery beneficial in gastroschisis?. J Pediatr Surg, 49(6), 928 - 933. doi:10.1016/j.jpedsurg.2014.01.027
    • Pacilli M, Eaton S, McHoney M, Kiely EM, Drake DP, Curry JI, Lindley KJ, Pierro A (2014). Four year follow-up of a randomised controlled trial comparing open and laparoscopic Nissen fundoplication in children.. Arch Dis Child, , - . doi:10.1136/archdischild-2013-304279
    • Hughes SD, Kanabus M, Anderson G, Hargreaves IP, Rutherford T, O'Donnell M, Cross JH, Rahman S, Eaton S, Heales SJ (2014). The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells.. J Neurochem, , - . doi:10.1111/jnc.12646
    • Mushtaq I, Garriboli M, Smeulders N, Cherian A, Desai D, Eaton S, Duffy P, Cuckow P (2014). Primary bladder exstrophy closure in neonates: challenging the traditions.. J Urol, 191(1), 193 - 198. doi:10.1016/j.juro.2013.07.020
    • Zani A, Cananzi M, Lauriti G, Fascetti-Leon F, Pierro A, Eaton S, De Coppi P, Wells J, Siow B, Lythgoe MF (2014). Amniotic fluid stem cells prevent development of ascites in a neonatal rat model of necrotizing enterocolitis. European Journal of Pediatric Surgery, 24(1), 57 - 60. doi:10.1055/s-0033-1350059
    • Evennett N, Cerigioni E, Hall NJ, Pierro A, Eaton S (2014). Smooth muscle actin as a novel serologic marker of severe intestinal damage in rat intestinal ischemia-reperfusion and human necrotising enterocolitis.. J Surg Res, , - . doi:10.1016/j.jss.2014.04.020

    2013

    • Totonelli G, Maghsoudlou P, Georgiades F, Garriboli M, Koshy K, Turmaine M, Ashworth M, Sebire NJ, Pierro A, Eaton S, De Coppi P (2013). Detergent enzymatic treatment for the development of a natural acellular matrix for oesophageal regeneration.. Pediatr Surg Int, 29(1), 87 - 95. doi:10.1007/s00383-012-3194-3
    • Gordon-smith SB, Eaton S, Ursu S, Wedderburn LR (2013). Lymphocytes from the inflamed joint of Juvenile Idiopathic Arthritis patients express reduced levels of CD73 and have a functional defect in adenosine production.
    • Franzin C, Piccoli M, Serena E, Bertin E, Urbani L, Luni C, Pasqualetto V, Eaton S, Elvassore N, De Coppi P, Pozzobon M (2013). Single cell PCR analysis of murine embryonic stem cells cultured on different substrates highlights heterogeneous expression of stem cell markers.. Biol Cell, , - . doi:10.1111/boc.201300034
    • Hall NJ, Eaton S, Pierro A (2013). Necrotizing enterocolitis: Prevention, treatment, and outcome.. J Pediatr Surg, 48(12), 2359 - 2367. doi:10.1016/j.jpedsurg.2013.08.006
    • Owino V, Kasonka L, Wells J, Eaton S, Sinkala M, Tomkins A, Darch T, Filteau S (2013). BREAST MILK INTAKE OF 9-MONTH OLD ZAMBIAN INFANTS GIVEN FORTIFIED COMPLEMENTARY FOODS. ANNALS OF NUTRITION AND METABOLISM, 63, 554 - 554.
    • Hallal PC, Reichert FF, Clark VL, Cordeira KL, Menezes AM, Eaton S, Ekelund U, Wells JC (2013). Energy expenditure compared to physical activity measured by accelerometry and self-report in adolescents: a validation study.. PLoS One, 8(11), e77036 - . doi:10.1371/journal.pone.0077036
    • Aylett SB, Neergheen V, Hargreaves IP, Eaton S, Land JM, Rahman S, Heales SJ (2013). Levels of 5-methyltetrahydrofolate and ascorbic acid in cerebrospinal fluid are correlated: Implications for the accelerated degradation of folate by reactive oxygen species. Neurochem.Int., , - . doi:10.1016/j.neuint.2013.10.002
    • Maghsoudlou P, Totonelli G, Loukogeorgakis SP, Eaton S, De Coppi P (2013). A decellularization methodology for the production of a natural acellular intestinal matrix.. J Vis Exp, (80), - . doi:10.3791/50658
    • Eaton S, Zani A, Pierro A, De Coppi P (2013). Stem cells as a potential therapy for necrotizing enterocolitis.. Expert Opin Biol Ther, , - . doi:10.1517/14712598.2013.849690
    • Carnaghan H, Roberts T, Savery D, Norris F, McCann CJ, Copp AJ, Scambler P, Lythgoe M, Greene NDE, DeCoppi P, Burns A, Pierro A, Eaton S (2013). Novel exomphalos genetic mouse model: the importance of accurate phenotypic characterisation.. Journal of Pediatric Surgery, 48(10), 2036 - 2042. doi:10.1016/j.jpedsurg.2013.04.010.
    • Eaton S, Hall NJ (2013). The potential of probiotics in the fight against necrotizing enterocolitis.. Expert Rev Gastroenterol Hepatol, 7(7), 581 - 583. doi:10.1586/17474124.2013.827480
    • Zani A, Eaton S, Hoellwarth M, Puri P, Tovar J, Fasching G, Bagolan P, Lukac M, Wijnen R, Kuebler J, Cecchetto G, Rintala R, Pierro A (2013). Management of Pediatric Inguinal Hernias in the Era of Laparoscopy: Results of an International Survey.. Eur J Pediatr Surg, , - . doi:10.1055/s-0033-1354586
    • Ghionzoli M, Repele A, Sartiani L, Costanzi G, Parenti A, Spinelli V, David AL, Garriboli M, Totonelli G, Tian J, Andreadis ST, Cerbai E, Mugelli A, Messineo A, Pierro A, Eaton S, De Coppi P (2013). Human amniotic fluid stem cell differentiation along smooth muscle lineage.. FASEB J, , - . doi:10.1096/fj.12-218578
    • Zani A, Eaton S, Hoellwarth ME, Puri P, Tovar J, Fasching G, Bagolan P, Lukac M, Wijnen R, Kuebler JF, Cecchetto G, Rintala R, Pierro A (2013). International Survey on the Management of Esophageal Atresia.. Eur J Pediatr Surg, , - . doi:10.1055/s-0033-1350058
    • Lauriti G, Zani A, Aufieri R, Cananzi M, Chiesa PL, Eaton S, Pierro A (2013). Incidence, Prevention, and Treatment of Parenteral Nutrition-Associated Cholestasis and Intestinal Failure-Associated Liver Disease in Infants and Children: A Systematic Review.. JPEN J Parenter Enteral Nutr, , - . doi:10.1177/0148607113496280
    • Eaton S, Thyoka M, Pierro A, Sebire N (2013). Histologic and Immunohistochemical Features Associated with Outcome in Neonatal Necrotizing Enterocolitis. European Journal of Pediatric Surgery, , - . doi:10.1055/s-0033-1349716
    • Nielsen SB, Wells JC, Fewtrell MS, Eaton S, Grinham J, Reilly JJ (2013). Validation of energy requirement references for exclusively breast-fed infants.. Br J Nutr, 109(11), 2036 - 2043. doi:10.1017/S000711451200428X
    • Repele A, Lupi R, Eaton S, Urbani L, De Coppi P, Campanella M (2013). Cell metabolism sets the differences between subpopulations of satellite cells (SCs).. BMC Cell Biol, 14, 24 - . doi:10.1186/1471-2121-14-24
    • Maghsoudlou P, Georgiades F, Tyraskis A, Totonelli G, Loukogeorgakis SP, Orlando G, Shangaris P, Lange P, Delalande JM, Burns AJ, Cenedese A, Sebire NJ, Turmaine M, Guest BN, Alcorn JF, Atala A, Birchall MA, Elliott MJ, Eaton S, Pierro A, Gilbert TW, De Coppi P (2013). Preservation of micro-architecture and angiogenic potential in a pulmonary acellular matrix obtained using intermittent intra-tracheal flow of detergent enzymatic treatment.. Biomaterials, 34(28), 6638 - 6648. doi:10.1016/j.biomaterials.2013.05.015
    • Kubiak R, Eaton S, Andrews J, Grant HW (2013). Long-Term Catch-Up Weight Gain Following Fundoplication in Children. EUROPEAN JOURNAL OF PEDIATRIC SURGERY, 23(2), 121 - 126. doi:10.1055/s-0032-1324801
    • Bishay M, Giacomello L, Retrosi G, Thyoka M, Garriboli M, Brierley J, Harding L, Scuplak S, Cross KM, Curry JI, Kiely EM, De Coppi P, Eaton S, Pierro A (2013). Hypercapnia and acidosis during open and thoracoscopic repair of congenital diaphragmatic hernia and esophageal atresia: results of a pilot randomized controlled trial.. Ann Surg, 258(6), 895 - 900. doi:10.1097/SLA.0b013e31828fab55
    • Duberley KE, Hargreaves IP, Chaiwatanasirikul KA, Heales SJ, Land JM, Rahman S, Mills K, Eaton S (2013). Coenzyme Q10 quantification in muscle, fibroblasts and cerebrospinal fluid by liquid chromatography/tandem mass spectrometry using a novel deuterated internal standard.. Rapid Commun Mass Spectrom, 27(9), 924 - 930. doi:10.1002/rcm.6529
    • Eaton S, Klein N, Ong E, Pierro A (2013). Authors' reply: Randomized clinical trial of glutamine-supplemented versus standard parenteral nutrition in infants with surgical gastrointestinal disease (Br J Surg 2012; 99: 929-938).. Br J Surg, 100(6), 841 - 842. doi:10.1002/bjs.9126
    • Eaton S (2013). Combining data from multiple studies: an introduction to meta-analysis in paediatric surgery.. J Pediatr Surg, 48(2), 281 - 287. doi:10.1016/j.jpedsurg.2012.11.004
    • Bishay M, Lakshminarayanan B, Arnaud A, Garriboli M, Cross KM, Curry JI, Drake D, Kiely EM, De Coppi P, Pierro A, Eaton S (2013). The role of parenteral nutrition following surgery for duodenal atresia or stenosis.. Pediatr Surg Int, 29(2), 191 - 195. doi:10.1007/s00383-012-3200-9
    • Singh RR, Eaton S, Cross KM, Curry JI, De Coppi P, Kiely EM, Roebuck DJ, Pierro A (2013). Management of a complication of percutaneous gastrostomy in children.. Eur J Pediatr Surg, 23(1), 76 - 79. doi:10.1055/s-0032-1330844
    • Garriboli M, Bishay M, Kiely EM, Drake DP, Curry JI, Cross KM, Eaton S, De Coppi P, Pierro A (2013). Recurrence rate of Morgagni diaphragmatic hernia following laparoscopic repair.. Pediatr Surg Int, 29(2), 185 - 189. doi:10.1007/s00383-012-3199-y
    • Thyoka M, Barnacle A, Chippington S, Eaton S, Drake DP, Cross KM, De Coppi P, Kiely EM, Pierro A, Curry JI, Roebuck DJ (2013). Fluoroscopic Balloon Dilation of Esophageal Atresia Anastomotic Strictures in Children and Young Adults: Single-Center Study of 103 Consecutive Patients from 1999 to 2011.. Radiology, , 122184 - . doi:10.1148/radiol.13122184

    2012

    • Totonelli G, Maghsoudlou P, Garriboli M, Georgiades F, Delalande JM, Thapar N, Pierro A, Eaton S, Burns AJ, De Coppi P (2012). Recellularization of a natural intestinal matrix using chicken chorioallantoic membrane as an in vivo bioreactor.
    • Mead EL, Mosley A, Eaton S, Dobson L, Heales SJ, Pocock JM (2012). Microglial neurotransmitter receptors trigger superoxide production in microglia; consequences for microglial-neuronal interactions.. J Neurochem, 121(2), 287 - 301. doi:10.1111/j.1471-4159.2012.07659.x
    • Hall NJ, Choi W, Pierro A, Eaton S (2012). Age-related probability of contralateral processus vaginalis patency in children with unilateral inguinal hernia.. Pediatr Surg Int, 28(11), 1085 - 1088. doi:10.1007/s00383-012-3174-7
    • Garriboli M, Eaton S, Pierro A, De Coppi P (2012). More patches or more lung in congenital diaphragmatic hernia?. Journal of Pediatric Surgery, 47(10), 1968 - 1969. doi:10.1016/j.jpedsurg.2012.06.025
    • Choi W, Hall NJ, Garriboli M, Ron O, Curry JI, Cross K, Drake DP, Kiely EM, Eaton S, De Coppi P, Pierro A (2012). Outcomes following laparoscopic inguinal hernia repair in infants compared with older children. Pediatric Surgery International, , 1 - 5.
    • Garriboli M, Duess JW, Ruttenstock E, Bishay M, Eaton S, De Coppi P, Puri P, Höllwarth ME, Pierro A (2012). Trends in the treatment and outcome of congenital diaphragmatic hernia over the last decade. Pediatric Surgery International, , 1 - 5.
    • Svensson JF, Hall NJ, Eaton S, Pierro A, Wester T (2012). A Review of Conservative Treatment of Acute Appendicitis. EUROPEAN JOURNAL OF PEDIATRIC SURGERY, 22(3), 185 - 194. doi:10.1055/s-0032-1320014
    • Duberley KEC, Hargreaves IP, Chaiwatanasirikul K, Heales SJ, Rahman S, Mills K, Eaton S (2012). DEVELOPMENT OF A MASS SPECTROMETRY METHOD (MS/MS) FOR QUANTIFICATION OF COENZYME Q10 IN CSF.
    • Heslegrave AJ, Kapoor RR, Eaton S, Chadefaux B, Akcay T, Simsek E, Flanagan SE, Ellard S, Hussain K (2012). Leucine-sensitive hyperinsulinaemic hypoglycaemia in patients with loss of function mutations in 3-Hydroxyacyl-CoA Dehydrogenase.. Orphanet J Rare Dis, 7(1), 25 - . doi:10.1186/1750-1172-7-25
    • Wells JC, Jonsdottir OH, Hibberd PL, Fewtrell MS, Thorsdottir I, Eaton S, Lucas A, Gunnlaugsson G, Kleinman RE (2012). Randomized controlled trial of 4 compared with 6 mo of exclusive breastfeeding in Iceland: differences in breast-milk intake by stable-isotope probe.. Am J Clin Nutr, 96(1), 73 - 79. doi:10.3945/ajcn.111.030403
    • Ghionzoli M, James CP, David AL, Shah D, Tan AW, Iskaros J, Drake DP, Curry JI, Kiely EM, Cross K, Eaton S, De Coppi P, Pierro A (2012). Gastroschisis with intestinal atresia--predictive value of antenatal diagnosis and outcome of postnatal treatment.. J Pediatr Surg, 47(2), 328 - 328. doi:10.1016/j.jpedsurg.2011.11.022
    • Pacilli M, Eaton S, Clarke A, Whitehead A, Nagy A, Brain JL (2012). Clinical significance of eosinophilia and chronic inflammatory infiltrate in children's rectal biopsies.. J Pediatr Gastroenterol Nutr, 55(5), 519 - 522. doi:10.1097/MPG.0b013e31825b3169
    • Heywood W, Wang D, Madgett TE, Avent ND, Eaton S, Chitty LS, Mills K (2012). The development of a peptide SRM-based tandem mass spectrometry assay for prenatal screening of Down syndrome.. J Proteomics, 75(11), 3248 - 3257. doi:10.1016/j.jprot.2012.03.037
    • Padidela R, Bennett K, Nessa A, Wells J, Aufieri R, James C, Smith VV, Brain C, Eaton S, Hussain K (2012). Severe resistance to weight gain, lack of stored triglycerides in adipose tissue, hypoglycaemia, and increased energy expenditure: a novel disorder of energy homeostasis.. Horm Res Paediatr, 77(4), 261 - 268. doi:10.1159/000337248
    • Ong EG, Eaton S, Wade AM, Horn V, Losty PD, Curry JI, Sugarman ID, Klein NJ, Pierro A, SIGN Trial Group (2012). Randomized clinical trial of glutamine-supplemented versus standard parenteral nutrition in infants with surgical gastrointestinal disease.. Br J Surg, 99(7), 929 - 938. doi:10.1002/bjs.8750
    • Carrington EV, Hall NJ, Pacilli M, Drake DP, Curry JI, Kiely EM, De Coppi P, Pierro A, Eaton S (2012). Cost-effectiveness of laparoscopic versus open pyloromyotomy.. J Surg Res, 178(1), 315 - 320. doi:10.1016/j.jss.2012.01.031
    • Macharia EW, Eaton S, de Coppi P, Curry J, Drake D, Cross K, Kiely E, Pierro A (2012). Fundoplication in ventilator-dependent infants with gastro-oesophageal reflux.. Eur J Pediatr Surg, 22(1), 91 - 96. doi:10.1055/s-0032-1306265
    • Thyoka M, Eaton S, Hall NJ, Drake D, Kiely E, Curry J, Cross K, de Coppi P, Pierro A (2012). Advanced necrotizing enterocolitis part 2: recurrence of necrotizing enterocolitis.. Eur J Pediatr Surg, 22(1), 13 - 16. doi:10.1055/s-0032-1306264
    • Thyoka M, de Coppi P, Eaton S, Khoo K, Hall NJ, Curry J, Kiely E, Drake D, Cross K, Pierro A (2012). Advanced necrotizing enterocolitis part 1: mortality.. Eur J Pediatr Surg, 22(1), 8 - 12. doi:10.1055/s-0032-1306263
    • Nah SA, de Coppi P, Kiely EM, Curry JI, Drake DP, Cross K, Spitz L, Eaton S, Pierro A (2012). Duhamel pull-through for Hirschsprung disease: a comparison of open and laparoscopic techniques.. J Pediatr Surg, 47(2), 308 - 312. doi:10.1016/j.jpedsurg.2011.11.025
    • Bishay M, Pichler J, Horn V, Macdonald S, Ellmer M, Eaton S, Hill S, Pierro A (2012). Intestinal failure-associated liver disease in surgical infants requiring long-term parenteral nutrition.. J Pediatr Surg, 47(2), 359 - 362. doi:10.1016/j.jpedsurg.2011.11.032
    • Ghionzoli M, James CP, David AL, Shah D, Tan AW, Iskaros J, Drake DP, Curry JI, Kiely EM, Cross K, Eaton S, De Coppi P, Pierro A (2012). Gastroschisis with intestinal atresia--predictive value of antenatal diagnosis and outcome of postnatal treatment.. J Pediatr Surg, 47(2), 322 - 328. doi:10.1016/j.jpedsurg.2011.11.022
    • Totonelli G, Maghsoudlou P, Garriboli M, Riegler J, Orlando G, Burns AJ, Sebire NJ, Smith VV, Fishman JM, Ghionzoli M (2012). A rat decellularized small bowel scaffold that preserves villus-crypt architecture for intestinal regeneration. Biomaterials, 33(12), 3401 - 3410. doi:10.1016/j.biomaterials.2012.01.012
    • Bishay M, Retrosi G, Horn V, Cloutman-Green E, Harris K, de Coppi P, Klein N, Eaton S, Pierro A (2012). Septicaemia due to enteric organisms is a later event in surgical infants requiring parenteral nutrition.. Eur J Pediatr Surg, 22(1), 50 - 53. doi:10.1055/s-0031-1287853
    • Carnaghan H, Johnson H, Eaton S, de Coppi P, Curry J, Morova M, Cross K, Drake D, Kiely E, Pierro A (2012). Effectiveness of the antegrade colonic enema stopper at preventing stomal stenosis: long-term follow-up.. Eur J Pediatr Surg, 22(1), 26 - 28. doi:10.1055/s-0031-1285874
    • Totonelli G, Maghsoudlou P, Fishman JM, Orlando G, Ansari T, Sibbons P, Birchall MA, Pierro A, Eaton S, De Coppi P (2012). Esophageal tissue engineering: a new approach for esophageal replacement.. World J Gastroenterol, 18(47), 6900 - 6907. doi:10.3748/wjg.v18.i47.6900
    • Sim R, Hall NJ, de Coppi P, Eaton S, Pierro A (2012). Core temperature falls during laparotomy in infants with necrotizing enterocolitis.. Eur J Pediatr Surg, 22(1), 45 - 49. doi:10.1055/s-0031-1284360
    • Aylett S-B, Neergheen V, Eaton S, Land JM, Rahman S, Heales SJ (2012). FACTORS AFFECTING 5-METHYLTETRAHYDROFOLATE (5MTHF) STABILITY: IMPLICATIONS FOR CEREBRAL 5MTHF DEFICIENCY.

    2011

    • Hall NJ, Ron O, Eaton S, Pierro A (2011). Surgery for hydrocele in children-an avoidable excess?. J Pediatr Surg, 46(12), 2401 - 2405. doi:10.1016/j.jpedsurg.2011.07.029
    • Zani A, Nah SA, Ron O, Totonelli G, Ismail D, Smith VV, Ashworth M, Blankenstein O, Mohnike W, De Coppi P, Eaton S, Hussain K, Pierro A (2011). The predictive value of preoperative fluorine-18-L-3,4-dihydroxyphenylalanine positron emission tomography-computed tomography scans in children with congenital hyperinsulinism of infancy.. J Pediatr Surg, 46(1), 204 - 208. doi:10.1016/j.jpedsurg.2010.09.093
    • McHoney M, Wade AM, Eaton S, Howard RF, Kiely EM, Drake DP, Curry JI, Pierro A (2011). Clinical outcome of a randomized controlled blinded trial of open versus laparoscopic Nissen fundoplication in infants and children.. Ann Surg, 254(2), 209 - 216. doi:10.1097/SLA.0b013e318226727f
    • Retrosi G, Sebire NJ, Bishay M, Kiely EM, Anderson J, De Coppi P, Resca E, Rampling D, Bier N, Mills K, Eaton S, Pierro A (2011). Brain lipid-binding protein: a marker of differentiation in neuroblastic tumors.. J Pediatr Surg, 46(6), 1197 - 1200. doi:10.1016/j.jpedsurg.2011.03.053
    • Bishay M, Retrosi G, Horn V, Cloutman-Green E, Harris K, De Coppi P, Klein N, Eaton S, Pierro A (2011). Chlorhexidine antisepsis significantly reduces the incidence of sepsis and septicemia during parenteral nutrition in surgical infants.. J Pediatr Surg, 46(6), 1064 - 1069. doi:10.1016/j.jpedsurg.2011.03.028
    • Moncrieffe H, Nistala K, Eaton S, Wedderburn LR (2011). A novel defect: CD39+T cells are enriched in the inflamed joint but do not suppress. CLIN EXP RHEUMATOL, 29(2), 376 - 376.
    • Wells JC, Haroun D, Williams JE, Darch T, Eaton S, Viner R, Fewtrell MS (2011). Evaluation of lean tissue density for use in air displacement plethysmography in obese children and adolescents.. Eur J Clin Nutr, 65(10), 1094 - 1101. doi:10.1038/ejcn.2011.76
    • Hall NJ, Jones CE, Eaton S, Stanton MP, Burge DM (2011). Is interval appendicectomy justified after successful nonoperative treatment of an appendix mass in children? A systematic review.. J Pediatr Surg, 46(4), 767 - 771. doi:10.1016/j.jpedsurg.2011.01.019
    • Hall NJ, Eaton S, Pierro A (2011). Editorial on "Open versus laparoscopic pyloromyotomy for pyloric stenosis: a meta-analysis of randomized controlled trials" by Jia et al.. Eur J Pediatr Surg, 21(2), 75 - 76. doi:10.1055/s-0031-1275323
    • Pacilli M, Eaton S, Fell JM, Rawat D, Clarke S, Haddad MJ (2011). Surgery in children with Crohn disease refractory to medical therapy.. J Pediatr Gastroenterol Nutr, 52(3), 286 - 290. doi:10.1097/MPG.0b013e3181e999af
    • Retrosi G, Bishay M, Kiely EM, Sebire NJ, Anderson J, Elliott M, Drake DP, Coppi PD, Eaton S, Pierro A (2011). Morbidity after ganglioneuroma excision: is surgery necessary?. Eur J Pediatr Surg, 21(1), 33 - 37. doi:10.1055/s-0030-1263195
    • Nah SA, Giacomello L, Eaton S, de Coppi P, Curry JI, Drake DP, Kiely EM, Pierro A (2011). Surgical repair of incarcerated inguinal hernia in children: laparoscopic or open?. Eur J Pediatr Surg, 21(1), 8 - 11. doi:10.1055/s-0030-1262793
    • Eaton S (2011). Protecting the bowel of premature infants.. Br J Nutr, 106(6), 793 - 794. doi:10.1017/S0007114511001280
    • Thyoka M, Eaton S, Kiely EM, Curry JI, Drake DP, Cross KM, Hall NJ, Khoo AK, De Coppi P, Pierro A (2011). Outcomes of diverting jejunostomy for severe necrotizing enterocolitis.. J Pediatr Surg, 46(6), 1041 - 1044. doi:10.1016/j.jpedsurg.2011.03.024
    • Bishay M, Giacomello L, Retrosi G, Thyoka M, Nah SA, McHoney M, De Coppi P, Brierley J, Scuplak S, Kiely EM, Curry JI, Drake DP, Cross KM, Eaton S, Pierro A (2011). Decreased cerebral oxygen saturation during thoracoscopic repair of congenital diaphragmatic hernia and esophageal atresia in infants.. J Pediatr Surg, 46(1), 47 - 51. doi:10.1016/j.jpedsurg.2010.09.062
    • Nielsen SB, Reilly JJ, Fewtrell MS, Eaton S, Grinham J, Wells JC (2011). Adequacy of milk intake during exclusive breastfeeding: a longitudinal study.. Pediatrics, 128(4), e907 - e914. doi:10.1542/peds.2011-0914

    2010

    • McHoney M, Eaton S, Wade A, Carnielli V, Kiely E, Drake D, Curry J, Pierro A (2010). Effect of laparoscopy and laparotomy on energy and protein metabolism in children: a randomized controlled trial.. J Pediatr, 157(3), 439 - 444.e2. doi:10.1016/j.jpeds.2010.02.067
    • Rees CM, Eaton S, Pierro A (2010). National prospective surveillance study of necrotizing enterocolitis in neonatal intensive care units.. J Pediatr Surg, 45(7), 1391 - 1397. doi:10.1016/j.jpedsurg.2009.12.002
    • Barry SP, Lawrence KM, McCormick J, Soond SM, Hubank M, Eaton S, Sivarajah A, Scarabelli TM, Knight RA, Thiemermann C, Latchman DS, Townsend PA, Stephanou A (2010). New targets of urocortin-mediated cardioprotection.. J Mol Endocrinol, 45(2), 69 - 85. doi:10.1677/JME-09-0148
    • Moncrieffe H, Nistala K, Kamhieh Y, Evans J, Eddaoudi A, Eaton S, Wedderburn LR (2010). High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population.. J Immunol, 185(1), 134 - 143. doi:10.4049/jimmunol.0803474
    • Evennett NJ, Hall NJ, Pierro A, Eaton S (2010). Urinary intestinal fatty acid-binding protein concentration predicts extent of disease in necrotizing enterocolitis.. J Pediatr Surg, 45(4), 735 - 740. doi:10.1016/j.jpedsurg.2009.09.024
    • Hall NJ, Eaton S, Peters MJ, Hiorns MP, Alexander N, Azzopardi DV, Pierro A (2010). Mild controlled hypothermia in preterm neonates with advanced necrotizing enterocolitis.. Pediatrics, 125(2), e300 - e308. doi:10.1542/peds.2008-3211
    • Pierro A, Eaton S, Rees CM, De Coppi P, Kiely EM, Peters MJ, Brierley J (2010). Is there a benefit of peritoneal drainage for necrotizing enterocolitis in newborn infants?. J Pediatr Surg, 45(11), 2117 - 2118. doi:10.1016/j.jpedsurg.2010.09.001
    • McHoney M, Giacomello L, Nah SA, De Coppi P, Kiely EM, Curry JI, Drake DP, Eaton S, Pierro A (2010). Thoracoscopic repair of congenital diaphragmatic hernia: intraoperative ventilation and recurrence.. J Pediatr Surg, 45(2), 355 - 359. doi:10.1016/j.jpedsurg.2009.10.072
    • Zani A, Ghionzoli M, Lauriti G, Cananzi M, Smith VV, Pierro A, De Coppi P, Eaton S (2010). Does intestinal permeability lead to organ failure in experimental necrotizing enterocolitis?. Pediatr Surg Int, 26(1), 85 - 89. doi:10.1007/s00383-009-2507-7
    • Ghionzoli M, Cananzi M, Zani A, Rossi CA, Leon FF, Pierro A, Eaton S, De Coppi P (2010). Amniotic fluid stem cell migration after intraperitoneal injection in pup rats: implication for therapy.. Pediatr Surg Int, 26(1), 79 - 84. doi:10.1007/s00383-009-2504-x
    • Haroun D, Taylor SJ, Viner RM, Hayward RS, Darch TS, Eaton S, Cole TJ, Wells JC (2010). Validation of bio-electrical impedance analysis in adolescents across different ethnic groups. Obesity, 18, 1252 - 1259.
    • Wells JC, Williams JE, Wilson C, Darch T, Viner RM, Eaton S, Fewtrell MS (2010). Evaluation of DXA against the four-component model of body composition in obese children and adolescents aged 5 to 21 years. International Journal of Obesity, 34(4), 649 - 655.
    • Rees CM, Eaton S, Khoo AK, Kiely EM, Members of NET Trial Group , Pierro A (2010). Peritoneal drainage does not stabilize extremely low birth weight infants with perforated bowel: data from the NET Trial.. J Pediatr Surg, 45(2), 324 - 328. doi:10.1016/j.jpedsurg.2009.10.066

    2009

    • Eaton S, McHoney M, Giacomello L, Pacilli M, Bishay M, De Coppi P, Wood J, Cohen R, Pierro A (2009). Carbon dioxide absorption and elimination in breath during minimally invasive surgery. J BREATH RES, 3(4), - . doi:10.1088/1752-7155/3/4/047005
    • Evennett N, Alexander N, Petrov M, Pierro A, Eaton S (2009). A systematic review of serologic tests in the diagnosis of necrotizing enterocolitis.. J Pediatr Surg, 44(11), 2192 - 2201. doi:10.1016/j.jpedsurg.2009.07.028
    • Eaton S, Hall NJ, Pierro A (2009). Zero-total event trials and incomplete pyloromyotomy. J PEDIATR SURG, 44(12), 2434 - 2435. doi:10.1016/j.jpedsurg.2009.08.028
    • Hall NJ, Eaton S, Pierro A (2009). The evidence base for neonatal surgery. Early Human Development, 85(11), 713 - 718.
    • McHoney M, Eaton S, Pierro A (2009). Metabolic response to surgery in infants and children. European Journal of Pediatric Surgery, 19(5), 275 - 285.
    • Haroun D, Croker H, Viner RM, Williams JE, Darch TS, Fewtrell MS, Eaton S, Wells JC (2009). Validation of BIA in Obese Children and Adolescents and Re-evaluation in a Longitudinal Study. Obesity (Silver.Spring), 17(12), 2245 - 2250.
    • Garrett-Cox RG, Stefanutti G, Booth C, Klein NJ, Pierro A, Eaton S (2009). Glutamine decreases inflammation in infant rat endotoxemia. J Pediatr Surg, 44(3), 523 - 529.
    • Garrett-Cox RG, Stefanutti G, Booth C, Klein NJ, Pierro A, Eaton S (2009). Glutamine decreases inflammation in infant rat endotoxemia.. J Pediatr Surg, 44(3), 523 - 529. doi:10.1016/j.jpedsurg.2008.09.007
    • Kimura Y, Pierro A, Eaton S (2009). Glutathione synthesis in intestinal ischaemia-reperfusion injury: effects of moderate hypothermia. J Pediatr Surg, 44(2), 353 - 357.
    • Hall NJ, Pacilli M, Eaton S, Reblock K, Gaines BA, Pastor A, Langer JC, Koivusalo AI, Pakarinen MP, Stroedter L, Beyerlein S, Haddad M, Clarke S, Ford H, Pierro A (2009). Recovery after open versus laparoscopic pyloromyotomy for pyloric stenosis: a double-blind multicentre randomised controlled trial. Lancet, 373(9661), 390 - 398.
    • Alexander N, Eaton S, Haston M, Wallace AS, Smith VV, Burns AJ, Salomon J, Shah N, Klein NJ, Pierro A, Thapar N (2009). Hirschsprung's disease associated enterocolitis is related to defects in innate immunity.
    • Kapoor RR, James C, Flanagan SE, Ellard S, Eaton S, Hussain K (2009). 3-Hydroxyacyl-Coenzyme A Dehydrogenase Deficiency and Hyperinsulinemic Hypoglycemia: Characterization of a Novel Mutation and Severe Dietary Protein Sensitivity. Journal of Clinical Endocrinology and Metabolism, 94(7), 2221 - 2225.
    • Zani A, Cananzi M, Eaton S, Pierro A, De Coppi P (2009). Stem cells as a potential treatment of necrotizing enterocolitis. Journal of Pediatric Surgery, 44(3), 659 - 660.
    • Lauriti G, Cananzi M, Pierro A, Eaton S, De Coppi P (2009). Intestinal Ischemia-reperfusion Injury Causes Activation of Bone Marrow-derived Progenitor Cells. European Journal of Pediatric Surgery, 19(6), 366 - 369.
    • Lauriti G, Cananzi M, Pierro A, Eaton S, de CP (2009). Intestinal ischemia-reperfusion injury causes activation of. Eur J Pediatr Surg, 19(6), 366 - 369.

    2008

    • Zani A, Cordischi L, Cananzi M, De Coppi P, Smith VV, Eaton S, Pierro A (2008). Assessment of a neonatal rat model of necrotizing enterocolitis.. Eur J Pediatr Surg, 18(6), 423 - 426. doi:10.1055/s-2008-1038951
    • Chandarana KA, Eaton SJ, Morgan MY (2008). Slow-release carbohydrates: A rational, patientacceptable approach for the nutritional management of patients with cirrhosis?.
    • Pacilli M, Pierro A, Lindley KJ, Curry JI, Eaton S (2008). Gastric emptying is accelerated following laparoscopic Nissen fundoplication.. Eur J Pediatr Surg, 18(6), 395 - 397. doi:10.1055/s-2008-1038919
    • Pierro A, Eaton S (2008). Metabolism and nutrition in the surgical neonate.. Semin Pediatr Surg, 17(4), 276 - 284. doi:10.1053/j.sempedsurg.2008.07.006
    • Hall NJ, Hiorns M, Tighe H, Peters M, Khoo AK, Eaton S, Pierro A (2008). Is Necrotizing Enterocolitis Associated with Development or Progression of Intraventricular Hemorrhage?. Am J Perinatol., , - .
    • Eaton S, Pacilli M, Wood J, McHoney M, Corizia L, Kingsley C, Curry JI, Herod J, Cohen R, Pierro A (2008). Factors affecting 13C-natural abundance measurement of breath carbon dioxide during surgery: absorption of carbon dioxide during endoscopic procedures.. Rapid Commun Mass Spectrom, 22(11), 1759 - 1762. doi:10.1002/rcm.3572
    • Stefanutti G, Pierro A, Parkinson EJ, Smith VV, Eaton S (2008). Moderate hypothermia as a rescue therapy against intestinal ischemia and reperfusion injury in the rat.. Crit Care Med, 36(5), 1564 - 1572. doi:10.1097/CCM.0b013e3181709e9f
    • Mavri-Damelin D, Damelin LH, Eaton S, Rees M, Selden C, Hodgson HJF (2008). Cells for bioartificial liver devices: The human hepatoma-derived cell line C3A produces urea but does not detoxify ammonia. BIOTECHNOL BIOENG, 99(3), 644 - 651. doi:10.1002/bit.21599
    • Zani A, Eaton S, Leon FF, Malerba A, Hall NJ, De CP, Smith VV, Pierro A (2008). Captopril reduces the severity of bowel damage in a neonatal rat model of necrotizing enterocolitis. J Pediatr Surg., 43(2), 308 - 314.
    • Zani A, Eaton S, Leon FF, Malerba A, Hall NJ, De Coppi P, Smith VV, Pierro A (2008). Captopril reduces the severity of bowel damage in a neonatal rat model of necrotizing enterocolitis.. J Pediatr Surg, 43(2), 308 - 314. doi:10.1016/j.jpedsurg.2007.10.022
    • Mavri-Damelin D, Damelin LH, Eaton S, Rees M, Selden C, Hodgson HJF (2008). Cells for bioartificial liver devices: The human hepatoma-derived cell line C3A produces urea but does not detoxify ammonia. Biotechnology and Bioengineering, 99(3), 644 - 651.
    • Rees CM, Eaton S, Kiely EM, Wade AM, McHugh K, Pierro A (2008). Peritoneal drainage or laparotomy in neonatal bowel perforation? A randomised controlled trial. Ann.Surg., 248(1), 44 - 51.
    • Zani A, Eaton S, Rees CM, Pierro A (2008). Incidentally detected Meckel diverticulum - To resect or not to resect?. Annals of Surgery, 247(2), 276 - 281.
    • Piastra M, Di Rocco C, Caresta E, Zorzi G, De Luca D, Caldarelli M, La Torre G, Conti G, Antonelli M, Eaton S, Pietrini D (2008). Blood loss and short-term outcome of infants undergoing brain tumour removal. Journal of Neuro-Oncology, 90(2), 191 - 200.
    • Khoo AK, Hall NJ, Alexander N, Evennett NJ, Pierro A, Eaton S (2008). Plasma soluble e-selectin in necrotising enterocolitis.. Eur J Pediatr Surg, 18(6), 419 - 422. doi:10.1055/s-2008-1038908

    2007

    • Piastra M, Caresta E, Zorzi G, De Luca D, Pietrini D, Conti G, Pierro A, Di Rocco C, Eaton S (2007). Early increase of lipid peroxidation in surgically induced brain injury: a possible target for neuroprotection?. ACTA PAEDIATR, 96, 124 - 124.
    • Stefanutti G, Pierro A, Smith VV, Klein NJ, Eaton S (2007). Peroxynitrite decomposition catalyst FeTMPyP provides partial protection against intestinal ischaemia and reperfusion injury in infant rats. Pediatric Research, 62(1), 43 - 48. doi:10.1203/PDR.0b013e31806790c0
    • Ron O, Eaton S, Pierro A (2007). Systematic review of the risk of developing a metachronous contralateral inguinal hernia in children. British Journal of Surgery, 94(7), 804 - 811. doi:10.1002/bjs.5856
    • Stefanutti G, Pierro A, Smith VV, Klein NJ, Eaton S (2007). Peroxynitrite decomposition catalyst FeTMPyP provides partial protection against intestinal ischemia and reperfusion injury in infant rats.. Pediatr Res, 62(1), 43 - 48. doi:10.1203/PDR.0b013e31806790c0
    • Ron O, Eaton S, Pierro A (2007). Systematic review of the risk of developing a metachronous contralateral inguinal hernia in children.. Br J Surg, 94(7), 804 - 811. doi:10.1002/bjs.5856
    • Bhattacharya K, Orton RC, Qi X, Mundy H, Morley DW, Champion MP, Eaton S, Tester RF, Lee PJ (2007). A novel starch for the treatment of glycogen storage diseases. J INHERIT METAB DIS, 30(3), 350 - 357. doi:10.1007/s10545-007-0479-0
    • Pacilli M, Eaton S, Maritsi D, Lopez PJ, Spitz L, Kiely EM, Drake DP, Curry JI, Pierro A (2007). Factors predicting failure of redo Nissen fundoplication in children. Pediatr.Surg.Int., 23(5), 499 - 503.
    • Caresta E, Pierro A, Chowdhury M, Peters MJ, Piastra M, Eaton S (2007). Oxidation of intravenous lipid in infants and children with systemic inflammatory response syndrome and sepsis. Pediatric Research, 61(2), 228 - 232. doi:10.1203/01.pdr.0000252441.91671.e5
    • Coelho R, Wells J, Smyth J, Semple R, O'Rahilly S, Eaton S, Hussain K (2007). Severe hypoinsulinaemic hypoglycaemia in a premature infant associated with poor weight gain and reduced adipose tissue. Hormone Research, 68, 91 - 98.
    • Owino VO, Kasonka LM, Sinkala MM, Wells JK, Eaton S, Darch T, Coward A, Tomkins AM, Filteau SM (2007). Fortified complementary foods with or without {alpha}-amylase treatment increase hemoglobin but do not reduce breast milk intake of 9 month old Zambian infants. American Journal of Clinical Nutrition, 86, 1094 - 1103.
    • Mavri-Damelin D, Eaton S, Damelin LH, Rees M, Hodgson HJ, Selden C (2007). Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2.. Int J Biochem Cell Biol, 39(3), 555 - 564. doi:10.1016/j.biocel.2006.10.007

    2006

    • Pacilli M, Pierro A, Kingsley C, Curry JI, Herod J, Eaton S (2006). Absorption of carbon dioxide during laparoscopy in children measured using a novel mass spectrometric technique. British Journal of Anaesthesia, 97 (2), 215 - 219.
    • McHoney M, Klein NJ, Eaton S, Pierro A (2006). Decreased monocyte class II MHC expression following major abdominal surgery in children is related to operative stress. Pediatric Surgery International, 22(4), 330 - 334.
    • Mavri-Damelin D, Eaton S, Coward S, Damelin L, Rees M, Selden C, Hodgson HJF (2006). Restoring urea cycle function in HepG2 cells by multiple gene transfer; A cell source for a bio-artificial liver device. Journal of Hepatology, 44, S144 - S144.
    • Geoghegan M, McAuley D, Eaton S, Powell-Tuck J (2006). Selenium in critical illness. Current Opinion in Critical Care, 12(2), 136 - 141.
    • McHoney MC, Corizia L, Eaton S, Wade A, Spitz L, Drake DP, Kiely EM, Tan HL, Pierro A (2006). Laparoscopic surgery in children is associated with an intraoperative hypermetabolic response. SURG ENDOSC, 20(3), 452 - 457.
    • Pierro A, Eaton S, Ong E (2006). Neonatal Physiology and Metabolic Considerations. In Grosveld JL, O'Neill JA, Fonkalsrud EW, Coran AG (Ed.), Pediatric Surgery (pp. 89 - 113). : Mosby Elsevier.
    • Hussain K, Clayton PT, Krywawych S, Chatziandreou I, Mills P, Ginbey DW, Geboers AJ, Berger R, van D, Eaton S (2006). RP408.
    • McCormick J, Barry SP, Sivarajah A, Stefanutti G, Townsend PA, Lawrence KM, Eaton S, Knight RA, Thiemermann C, Latchman DS, Stephanou A (2006). Free radical scavening inhibits STAT phosphorylation following in vivo ischaemia/reperfusion injury. The FASEB Journal, 20(12), 2115 - 2117. doi:10.1096/fj.06-6188fje
    • Rees CM, Pierro A, Eaton S (2006). Neurodevelopmental outcomes of neonates with medically and surgically treated necrotizing enterocolitis. Arch.Dis.Child Fetal Neonatal Ed, , - .
    • Muller WG, Morini F, Eaton S, Peters M, Jaffe A (2006). Safety and feasibility of exhaled breath condensate collection in ventilated infants and children. EUR RESPIR J, 28(3), 479 - 485.
    • Pacilli M, Pierro A, Kingsley C, Curry JI, Herod J, Eaton S (2006). Absorption of carbon dioxide during laparoscopy in children measured using a novel mass spectrometric technique.. Br J Anaesth, 97(2), 215 - 219. doi:10.1093/bja/ael134
    • Eaton S (2006). The biochemical basis of antioxidant therapy in critical illness.. Proc Nutr Soc, 65(3), 242 - 249.
    • Mavri-Damelin D, Eaton S, Coward S, Damelin L, Rees M, Selden C, Hodgson HJF (2006). Restoring urea cycle function in HepG2 cells by multiple gene transfer; A cell source for a bio-artificial liver device.
    • Pierro A, Eaton S (2006). Nutrition in the neonatal surgical patient. In Thureen P, Hay W (Ed.), Neonatal Nutrition and Metabolism (pp. 569 - 585). : Cambridge University Press.
    • Wade A, Pan H, Eaton S, Pierro A, Ong E (2006). An investigation of minimisation criteria. BMC MED RES METHODOL, 6, 11 - .
    • Muqit MMK, Abou-Sleiman PM, Saurin AT, Harvey K, Gandhi S, Deas E, Eaton S, Payne Smith MD, Venner K, Matilla A, Healy DG, Gilks WP, Lees AJ, Holton J, Revesz T, Parker PJ, Harvey RJ, Wood NW, Latchman DS (2006). Altered cleavage and localisation of PINK1 to aggresomes in the presence of proteasomal stress. Journal of Neurochemistry, 98, 156 - 159. doi:10.1111/j.1471-4159.2006.03845.x

    2005

    • Mills K, Eaton S, Ledger V, Young E, Winchester B (2005). The synthesis of internal standards for the quantitative determination of sphingolipids by tandem mass spectrometry. RAPID COMMUN MASS SPECTROM, 19(12), 1739 - 1748.
    • Stefanutti G, Pierro A, Vinardi S, Spitz L, Eaton S (2005). Moderate hypothermia protects against systemic oxidative stress in a rat model of intestinal ischemia and reperfusion injury. Shock, 24(2), 159 - 164. doi:10.1097/01.shk.0000168871.60531.6f
    • Hall NJ, Smith VV, Harding B, Pierro A, Eaton S (2005). Intestinal Ischemia-Reperfusion Injury Does not Lead to Acute Central Nervous System Damage. J SURG RES, 129, 288 - 291.
    • Parkinson EJ, Lawrence KM, Latchman DS, Eaton S, Pierro A (2005). Modulation by hypothermia of hepatic gene expression following intestinal ischaemia-reperfusion. P NUTR SOC, 64, 22A - 22A.
    • Chowdhury M, Eaton S, Peters MJ, Klein NJ, Goldman A, Pierro A (2005). Promotion of monocyte HLA-DR expression and attenuation of cytokine response by glutamine supplementation in septic children. P NUTR SOC, 64, 16A - 16A.
    • McHoney M, Carnielli VP, Eaton S, Howard R, Kiely EM, Drake DP, Spitz L, Pierro A (2005). Differential effects of laparoscopic and open surgery on post-operative protein metabolism. P NUTR SOC, 64, 10A - 10A.
    • Hall NJ, Peters M, Eaton S, Pierro A (2005). Association of hyperglycaemia with increased morbidity and mortality in neonates with necrotising enterocolitis. P NUTR SOC, 64, 7A - 7A.
    • Caresta E, Pierro A, Chowdhury M, Peters MJ, Petros AJ, Piastra M, Eaton S (2005). Intravenous lipid utilisation in infants and children with sepsis and systemic inflammatory response syndrome. P NUTR SOC, 64, 6A - 6A.
    • Hussain K, Clayton PT, Krywawych S, Chatziandreou I, Mills P, Ginbey DW, Geboers AJJM, Berger R, van den Berg IET, Eaton S (2005). Hyperinsulinism of infancy associated with a novel splice site mutation in the short-chain 3-hydroxyacyl-CoA dehydrogenase gene. The Journal of Pediatrics, 146(5), 706 - 708.
    • Eaton S, Pierro A (2005). Carnitine and Fatty acid Oxidation in Sepsis. Chemical Monthly, 136, 1483 - 1492.
    • Rees CM, Hall NJ, Eaton S, Pierro A (2005). Surgical strategies for necrotising enterocolitis: a survey of practice in the United Kingdom.. Arch Dis Child Fetal Neonatal Ed, 90(2), F152 - F155. doi:10.1136/adc.2004.051862
    • Hall NJ, Ali J, Pierro A, Eaton S (2005). Total glutathione is not decreased in infants with necrotizing enterocolitis.. J Pediatr Surg, 40(5), 769 - 773. doi:10.1016/j.jpedsurg.2005.01.039
    • Hussain K, Clayton PT, Krywawych S, Chatziandreou I, Mills P, Ginbey DW, Geboers AJJM, Berger R, Van den Berg IET, Eaton S (2005). Hyperinsulinism of infancy associated with a novel splice site mutation in the SCHAD gene. J PEDIATR, 146(5), 706 - 708. doi:10.1016/j.jpeds.2005.01.032
    • Stefanutti G, Lister P, Smith VV, Peters MJ, Klein NJ, Pierro A, Eaton S (2005). P-selectin expression, neutrophil infiltration, and histologic injury in neonates with necrotizing enterocolitis.. J Pediatr Surg, 40(6), 942 - 947. doi:10.1016/j.jpedsurg.2005.03.027
    • Duncan AJ, Heales SJR, Mills K, Eaton S, Land JM, Hargreaves IP (2005). Determination of coenzyme q10 status in blood mononuclear cells, skeletal muscle, and plasma by HPLC with di-propoxy-coenzyme q10 as an internal standard. Clinical Chemistry, 51(12), 2380 - 2381. doi:10.1373/clinchem.2005.054643
    • Hargreaves IP, Duncan A, Mills K, Eaton S, Land JM, Heales SJR (2005). Blood mononuclear cell, but not plasma coenzyme Q(10) concentration correlates with skeletal muscle levels: implications for diagnosis and treatment.
    • Stefanutti G, Pierro A, Vinardi S, Spitz L, Eaton S (2005). Moderate hypothermia protects against systemic oxidative stress in a rat model of intestinal ischemia and reperfusion injury.. Shock, 24(2), 159 - 164.
    • McHoney M, Eaton S, Wade A, Klein NJ, Stefanutti G, Booth C, Kiely EM, Curry JI, Drake DP, Pierro A (2005). Inflammatory response in children after laparoscopic vs open Nissen fundoplication: randomized controlled trial.. J Pediatr Surg, 40(6), 908 - 913. doi:10.1016/j.jpedsurg.2005.03.003

    2004

    • Stefanutti G, Vejchapipat P, Williams SR, Pierro A, Eaton S (2004). Heart energy metabolism after intestinal ischaemia and reperfusion. Journal of Pediatric Surgery, 39, 179 - 183.
    • Stefanutti G, Vejchapipat P, Williams SR, Pierro A, Eaton S (2004). Heart energy metabolism after intestinal ischaemia and reperfusion.. J Pediatr Surg, 39(2), 179 - 183.
    • Pierro A, Eaton S (2004). Intestinal ischemia reperfusion injury and multisystem organ failure. SEM PEDIATR SURG, 13(1), 11 - 17.
    • Hall NJ, Peters M, Eaton S, Pierro A (2004). Hyperglycemia is associated with increased morbidity and mortality rates in neonates with necrotizing enterocolitis. Journal of Pediatric Surgery, 39(6), 898 - 901.
    • Lawrence KM, Townsend PA, Davidson SM, Carroll CJ, Eaton S, Hubank M, Knight RA, Stephanou A, Latchman DS (2004). The cardioprotective effect of urocortin during ischaemia/reperfusion involves the prevention of mitochondrial damage. Biochemical and Biophysical Research Communications, 321(2), 479 - 486.
    • Basile M, Romeo C, Gitto E, Spitz L, Pierro A, Eaton S (2004). Melatonin protects from, but does not reverse, the effects of mediators of sepsis on liver bioenergetics. Pediatric Surgery International, 20(4), 263 - 266.
    • Eaton S, Hall N, Rees CM, Pierro A (2004). Necrotizing enterocolitis: pathogenesis, medical management and surgery. British Journal of Intensive Care, 14(3), 101 - 105.
    • Bartlett K, Eaton S (2004). Mitochondrial beta-oxidation. European Journal of Biochemistry, 271(3), 462 - 469.
    • Fukumoto K, Pierro A, Zammit VA, Spitz L, Eaton S (2004). Tyrosine nitration of carnitine palmitoyl transferase I during endotoxaemia in suckling rats. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1683(1-3), 1 - 6. doi:10.1016/j.bbalip.2004.03.006
    • Parkinson EJ, Townsend PA, Stephanou A, Latchman DS, Eaton S, Pierro A (2004). The protective effect of moderate hypothermia during intestinal ischemia-reperfusion is associated with modification of hepatic transcription factor activation. Journal of Pediatric Surgery, 39(5), 696 - 701.
    • Pierro A, Eaton S (2004). Nutrition in the neonatal surgical patient. In Hay WW, Thureen PJ (Ed.), Neonatal Nutrition and Metabolism (pp. - ). : Cambridge University Press.
    • Eaton S, Pierro A (2004). Glutathione in Systemic Inflammation and Sepsis. British Journal of Intensive Care, 14, 53 - 59.

    2003

    • Eaton S, Fukumoto K, Stefanutti G, Spitz L, Zammit VA, Pierro A (2003). Myocardial carnitine palmitoyltransferase I as a target for oxidative modification in inflammation and sepsis. Biochemical Society Transactions, 31(Pt 6), 1133 - 1136.
    • Eaton S, Chatziandreou I, Krywawych S, Pen S, Clayton PT, Hussain K (2003). Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency associated with hyperinsulinism: a novel glucose-fatty acid cycle?. Biochemical Society Transactions, 31(Pt 6), 1137 - 1139.
    • Eaton S (2003). Impaired energy metabolism during neonatal sepsis: the effects of glutamine. Proceedings of the Nutrition Society, 62(3), 745 - 751.
    • Ragazzi S, Pierro A, Peters M, Fasoli L, Eaton S (2003). Early full blood count and severity of disease in neonates with necrotizing enterocolitis. Pediatric Surgery International, 19(5), 376 - 379.
    • Hussain K, Eaton S, Clayton P (2003). Exogenous administered DL- sodium beta-hydroxybutyrate (beta-OHB) can cross the blood brain barrier. Pediatric Research, 53(5), 865 - 866.
    • Garrett-Cox RG, Pierro A, Spitz L, Eaton S (2003). Body temperature and heat production in suckling rat endotoxaemia: beneficial effects of glutamine. Journal of Pediatric Surgery, 38(1), 37 - 44.
    • McHoney M, Corizia L, Eaton S, Kiely EM, Drake DP, Tan HL, Spitz L, Pierro A (2003). Carbon dioxide elimination during laparoscopy in children is age dependent. Journal of Pediatric Surgery, 38(1), 105 - 110.
    • Vinardi S, Pierro A, Parkinson EJ, Vejchapipat P, Stefanutti G, Spitz L, Eaton S (2003). Hypothermia throughout intestinal ischaemia-reperfusion injury attenuates lung neutrophil infiltration.. J Pediatr Surg, 38(1), 88 - 91. doi:10.1053/jpsu.2003.50017
    • Fukumoto K, Pierro A, Spitz L, Eaton S (2003). Neonatal endotoxemia affects heart but not kidney bioenergetics. Journal of Pediatric Surgery, 38(5), 690 - 693.
    • Fukumoto K, Pierro A, Spitz L, Eaton S (2003). Cardiac and renal mitochondria respond differently to hydrogen peroxide in suckling rats. Journal Of Surgical Research, 113(1), 146 - 150.
    • Vinardi S, Pierro A, Parkinson EJ, Vejchapipat P, Stefanutti G, Spitz L, Eaton S (2003). Hypothermia throughout intestinal ischaemia-reperfusion injury attenuates lung neutrophil infiltration. Journal of Pediatric Surgery, 38(1), 88 - 91.

    2002

    • (2002). Mitochondrial Fatty Acid beta-Oxidation in the Retinal Pigment Epithelium. PEDIATR RES, 52, 595 - 600.
    • (2002). Fatty acid oxidation in neonatal hepatocytes: Effects of sepsis and glutamine. Nutrition, 18(4), 298 - 300.
    • Eaton S (2002). Very long-chain acyl-CoA dehydrogenase deficiency, in National Association for Rare Disorders (eds): The NORD Guide to Rare Disorders. In Lippincott PA (Ed.), (pp. 439 - 440). : Wlliamns & Wilkinspp.
    • (2002). Hepatic glutamine metabolism during endotoxemia in neonatal rats. Nutrition, 18(4), 293 - 297.
    • (2002). Hepatocyte mitochondrial metabolism is inhibited in neonatal rat endotoxaemia: effects of glutamine. Clinical Science, 102(3), 337 - 344.
    • Eaton S (2002). Long-chain acyl-CoA dehydrogenase deficiency, in National Association for Rare Disorders (eds) The NORD Guide to Rare Disorders. In Lippincott PA (Ed.), (pp. 4374 - ). : Williams & Wilkinspp.
    • (2002). Control of mitochondrial beta-oxidation flux. Progress in Lipid Research, 41, 197 - 239.
    • Donnell SC, Lloyd DA, Eaton S, Pierro A (2002). The metabolic response to intravenous medium-chain triglycerides in infants after surgery. The Journal of Pediatrics, 141(5), 689 - 694. doi:10.1067/mpd.2002.128889
    • Vejchapipat P, Eaton S, Fukumoto K, Parkes HG, Reynolds A, Spitz L, Pierro A (2002). Metabolic derangement during endotoxemia in neonatal rats.. , 10, 1919 - 1919.
    • (2002). Differential effects of neonatal endotoxemia on heart and kidney carnitine palmitoyl transferase I. Journal of Pediatric Surgery, 37(5), 723 - 726.

    2001

    • (2001). Endotoxaemia inhibits muscle-carnitine palmitoyl transferase I in suckling hea. Journal of Molecular and Cellular Cardiology, 33(6), A167 - A167.
    • New KJ, Eaton S, Elliott KRF, Spitz L, Quant PA (2001). Effect of lipopolysaccharide and cytokines on oxidative metabolism in neonatal rat hepatocytes. Journal of Pediatric Surgery, 36(2), 338 - 340.
    • Babu R, Eaton S, Drake DP, Spitz L, Pierro A (2001). Glutamine and glutathione counteract the inhibitory effects of mediators of sepsis in neonatal hepatocytes. Journal of Pediatric Surgery, 36(2), 282 - 286.
    • Clayton PT, Eaton SJ, Aynsley-Green A, Edginton M, Hussain K, Krywawych S, Datta V, Malingre HE, Berger R, van den Berg IE (2001). Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion. Journal of Clinical Investigation, 108(3), 457 - 465. doi:10.1172/JCI200111294
    • Turi RA, Petros AJ, Eaton S, Fasoli L, Powis M, Basu R, Spitz L, Pierro A (2001). Energy metabolism of infants and children with systemic inflammatory response syndrome and sepsis. Annals of Surgery, 233(4), 581 - 587. doi:10.1097/00000658-200104000-00015
    • (2001). Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux. Biochemical Society Transactions, 29, 245 - 250.
    • Ververidis M, Kiely EM, Spitz L, Drake DP, Eaton S, Pierro A (2001). The clinical significance of thrombocytopenia in neonates with necrotizing enterocolitis. Journal of Pediatric Surgery, 36(5), 799 - 803.
    • Eaton S, Bartlett K, Quant PA (2001). Carnitine palmitoyl transferase I and the control of beta-oxidation in heart mitochondria. Biochemical and Biophysical Research Communications, 285(2), 537 - 539.
    • Clayton PT, Eaton S, Aynsley-Green A, Edginton M, Hussain K, Krywawych S, Datta V, Malingre HE, Berger R, van den Berg IE (2001). Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion.. J Clin Invest, 108(3), 457 - 465. doi:10.1172/JCI11294

    2000

    • Markley MA, Eaton S, Pierro A (2000). Hepatocyte mitochondrial metabolism in neonatal sepsis is restored by glutamine. Proceedings of the Nutrition Society, 59, 153A - 153A.
    • Eaton S, Skinner R, Hale JP, Pourfarzam M, Roberts A, Price L, Bartlett K (2000). Plasma coenzyme Q(10) in children and adolescents undergoing doxorubicin therapy.. Clin Chim Acta, 302(1-2), 1 - 9.
    • Zamparelli M, Eaton S, Spitz L, Pierro A (2000). Amino acids counteract the inhibitory effect of fentanyl on hepatocyte oxidative metabolism. Journal of Pediatric Surgery, 35(5), 736 - 739.
    • Romeo C, Eaton S, Spitz L, Pierro A (2000). Nitric oxide inhibits neonatal hepatocyte oxidative metabolism. Journal of Pediatric Surgery, 35(1), 44 - 48.
    • Markley MA, Eaton S, Pierro A (2000). Neonatal hepatic oxidative metabolism following endotoxaemia. Proceedings of the Nutrition Society, 59, 162A - 162A.
    • Eaton S, Bursby T, Middleton B, Pourfarzam M, Mills K, Johnson AW, Bartlett K (2000). The mitochondrial trifunctional protein: centre of a beta-oxidation metabolon?. Biochemical Society Transactions, 28(Pt2), 177 - 182.
    • Eaton S, Skinner R, Hale JP, Pourfarzam M, Roberts A, Price L, Bartlett K (2000). Plasma coenzyme Q(10) in children and adolescents undergoing doxorubicin therapy. Clinica Chimica Acta, 302(1-2), 1 - 9.
    • Basu R, Muller DPR, Drury J, Cooke RW, Eaton S, Pierro A (2000). Intravenous medium-chain triacylglycerol administration is associated with increased free radical activity. Proceedings of the Nutrition Society, 59, 165A - 165A.
    • Romeo C, Eaton S, Spitz L, Pierro A (2000). Effect of nitric oxide on neonatal hepatocyte oxidative metabolism. Proceedings of the Nutrition Society, 59, 158A - 158A.

    1999

    • Eaton S, Middleton B, Sherratt HS, Pourfarzam M, Quant PA, Bartlett K (1999). Control of mitochondrial beta-oxidation at the levels of [NAD+]/[NADH] and CoA acylation.. Adv Exp Med Biol, 466, 145 - 154.
    • Eaton S, Bartlett K, Pourfarzam M, Markley MA, New KJ, Quant PA (1999). Production and export of acylcarnitine esters by neonatal rat hepatocytes.. Adv Exp Med Biol, 466, 155 - 159.
    • Eaton S, Bartlett K (1999). Tissue specific differences in intramitochondrial control of beta-oxidation.. Adv Exp Med Biol, 466, 161 - 168.
    • New KJ, Eaton S, Elliott KR, Quant PA (1999). Is it time to reconsider the role of CPT I in control of hepatic ketogenesis?. Adv Exp Med Biol, 466, 227 - 232.
    • Romeo C, Eaton S, Quant PA, Spitz L, Pierro A (1999). Neonatal oxidative liver metabolism: Effects of hydrogen peroxide, a putative mediator of septic damage. Journal of Pediatric Surgery, 34, 1107 - 1111.
    • Basu R, Muller DP, Eaton S, Merryweather I, Pierro A (1999). Lipid peroxidation can be reduced in infants on total parenteral nutrition by promoting fat utilisation. Journal of Pediatric Surgery, 34(2), 255 - 259.
    • Zamparelli M, Eaton S, Quant PA, McEwan A, Spitz L, Pierro A (1999). Analgesic doses of fentanyl impair oxidative metabolism of neonatal hepatocytes.. J Pediatr Surg, 34(2), 260 - 263.
    • Basu R, Muller DPR, Papp E, Merryweather I, Eaton S, Klein N, Pierro A (1999). Free radical formation in infants: The effect of critical illness, parenteral nutrition, and enteral feeding. Journal of Pediatric Surgery, 34, 1091 - 1095.
    • Eaton S, Bartlett K, Pourfarzam M (1999). Intermediates of myocardial mitochondrial beta-oxidation: possible channelling of NADH and of CoA esters. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1437(3), 402 - 408.

    1998

    • Quant PA, Lascelles CV, New KJ, Patil KK, Azzouzi N, Eaton S, Elliott KR (1998). Impaired neonatal hepatic ketogenesis.. Biochem Soc Trans, 26(2), 125 - 130.
    • Eaton S, Middleton B, Bartlett K (1998). Control of mitochondrial β-oxidation: sensitivity of the trifunctional protein to [NAD+]/[NADH] and [acetyl-CoA]/[CoA]. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1429(1), 230 - 238. doi:10.1016/S0167-4838(98)00246-5
    • Eaton S, Pourfarzam M, Bartlett K, Quant PA (1998). Beta-oxidation in neonatal cardiac mitochondria.. Biochem Soc Trans, 26(2), S91 - .

    • Hall NJ, Eaton S, Peters MJ, Hiorns M, Alexander N, Azzopardi D, Edwards AD, Pierro A (). Moderate Controlled Hypothermia in Neonates with Advanced Necrotising Enterocolitis: Feasibility and Safety Study. Pediatrics, , - .