Dr Helen Donoghue

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Personal Profile

Name: Helen Donoghue Email: h.donoghue@ucl.ac.uk
Title: Dr Tel: 0207 794 0500
Department: Div of Infection & Immunity Fax:
Position: Honorary Senior Lecturer Address: Research Department of Infection, Royal Free Campus, Rowland Hill Street, London, NW3 2QG
Research Domain: Global Health, Infection, Immunology & Inflammation, Personalised Medicine, Populations & Lifelong Health Web Page: Personal Web Page

Profile

Research Description

Origins and molecular characteristics of the causative organisms of tuberculosis and leprosy by direct detection in ancient samples. (See: http://www.ucl.ac.uk/infection-immunity/events/news.) Leprosy in Nicaragua and Honduras and its association with cutaneous leishmaniasis; Investigation of microbial and cellular characteristics of leprosy patients who develop late reactions;

Research Activities

Mycobacteria and mycobacterial diseases

molecular detection & characterisation of mycobacteria

Education Description

UCL Collaborators

External Collaborators

Publications

    2014

    • Darling MI, Donoghue HD (2014). Insights from paleomicrobiology into the indigenous peoples of pre-colonial America - a review. Mem Inst Oswaldo Cruz, Rio de Janeiro, 109(2), 131 - 139. doi:10.1590/0074-0276140589
    • Palfi G, Marcsik A, Pap I, Kustar A, Donoghue HD, Minnikin DE, Lee OY-C, Wu HHT, Besra GS, Bereczki Z, Spekker O, Molnar E (2014). Osteoarchaeological and paleomicrobiological evidence of leprosy in Hungary.
    • Donoghue HD, Spigelmen M, Pap I, Palfi G, Molnar E, Lee OY-C, Wu HH, Besra GS, Minnikin DE (2014). Molecular biomarker studies on the interrelation of ancient leprosy and tuberculosis.
    • Matheson CD, David R, Spigelman M, Donoghue HD (2014). Molecular confirmation of Schistosoma and family relationship in two ancient Egyptian mummies. In Gill-Frerking H, Rosendahl W, Zink AR, Alterauge A (Ed.), Yearbook of Mummy Studies Volume 2 (pp. 39 - 47). : Verlag Dr. Friedrich Pfeil.

    2013

    • Chan JZM, Sergeant MJ, Lee OYC, Minnikin DE, Besra GS, Pap I, Spigelman M, Donoghue HD, Pallen MJ (2013). Metagenomic Analysis of Tuberculosis in a Mummy. New England Journal of Medicine, 369(3), 289 - 290. doi:10.1056/NEJMc1302295
    • Donoghue HD (2013). Insights into ancient leprosy and tuberculosis using metagenomics. Trends in Microbiology, 21(9), 448 - 450. doi:10.1016/j.tim.2013.07.007
    • Masson M, Molnár E, Donoghue HD, Besra GS, Minnikin DE, Wu HHT, Lee OY-C, Bull ID, Pálfi G (2013). Osteological and biomolecular evidence of a 7000-year-old case of hypertrophic pulmonary osteopathy secondary to tuberculosis from Neolithic Hungary. PLoS ONE, 8(10), - . doi:10.1371/journal.pone.0078252

    2012

    • Lee OY-C, Wu HHT, Donoghue HD, Spigelman M, Greenblatt CL, Bull ID, Rothschild BM, Martin LD, Minnikin DE, Besra GS (2012). Mycobacterium tuberculosis Complex Lipid Virulence Factors Preserved in the 17,000 Year Old Skeleton of an Extinct Bison, Bison antiquus. PLoS One, 7(7), - . doi:10.1371/journal.pone.0041923
    • Lee OY-C, Bull ID, Molnár E, Marcsik A, Pálfi G, Donoghue HD, Besra GS, Minnikin DE (2012). Integrated strategies for the use of lipid biomarkers in the diagnosis of ancient mycobacterial disease.
    • Rubini M, Erdal YS, Spigelman M, Zaio P, Donoghue HD (2012). Paleopathological and molecular study on two cases of ancient childhood leprosy from the Roman and Byzantine Empires. International Journal of Osteoarchaeology, , - . doi:10.1002/oa.2242
    • Donoghue H (2012). Ancient tuberculosis and leprosy. Microbiologist, 13(1), 35 - 38.
    • Spigelman M, Erdal YS, Donoghue HD, Pinhasi R (2012). Golfer and tennis elbow in Byzantine Turkey: epichondylitis a neglected occupation/activity marker in antiquity. Advances in Anthropology, 2(1), 24 - 30. doi:10.4236/aa.2012.21003
    • Minnikin DE, Lee OYC, Wu HHT, Besra GS, Donoghue HD (2012). Molecular biomarkers for ancient tuberculosis. In Cardona P-J (Ed.), Understanding tuberculosis - deciphering the secret life of the bacilli (pp. 3 - 36). : InTech. doi:10.5772/30224
    • Donoghue HD (2012). Palaeomicrobiology of human infectious diseases. In UNESCO-EOLSS Joint Committee (Ed.), Global Perspectives in Health (pp. - ). : Eolss Publishers.
    • Hajdu T, Donoghue HD, Bernert Z, Fóthi E, Kővári I, Marcsik A (2012). A case of spinal tuberculosis from the Middle Ages in Transylvania (Romania). Spine, 37(25), e1598 - e1601. doi:10.1097/BRS.0b013e31827300dc

    2011

    • Donoghue HD, Pap I, Szikossy I, Spigelman M (2011). Detection and characterization of Mycobacterium tuberculosis DNA in 18th Century Hungarians with pulmonary and extra-pulmonary tuberculosis. In Gill-Frerking H, Rosendahl W, Zink A, Piombino-Mascasli D (Ed.), Yearbook of mummy studies (pp. 51 - 56). : Verlag Dr. Friedrich Pfeil.
    • Évinger S, Bernert Z, Fóthi E, Wolff K, Kővári I, Marcsik A, Donoghue HD, O'Grady J, Kiss K, Hajdu T (2011). New skeletal tuberculosis cases in past populations from Western Hungary (Transdanubia). HOMO – Journal of Comparative Human Biology, 62(3), 165 - 183. doi:10.1016/j.jchb.2011.04.001
    • Donoghue HD (2011). Insights gained from palaeomicrobiology into ancient and modern tuberculosis. Clinical Microbiology and Infection, 17(6), 821 - 829. doi:10.1111/j.1469-0691.2011.03554.x
    • Taylor GM, Donoghue HD (2011). Multiple loci variable number tandem repeat (VNTR) analysis (MLVA) of Mycobacterium leprae isolates amplified from European archaeological human remains with lepromatous leprosy. Microbes and Infection, 13(11), 923 - 929. doi:10.1016/j.micinf.2011.05.003
    • Minnikin DE, Besra GS, Lee O-C, Spigelman M, Donoghue HD (2011). The interplay of DNA and lipid biomarkers in the detection of tuberculosis and leprosy in mummies and other skeletal remains. In Gill-Frerking H, Rosendahl W, Zink A, Piombino-Mascasli D (Ed.), Yearbook of mummy studies (pp. 109 - 114). : Verlag Dr. Friedrich Pfeil.

    2010

    • Donoghue H, Marcsik A, Molnár E, Molto E, Erdal YS, Pinhasi R, Spigelman M, Taylor GM (2010). When and how did leprosy reach Europe? Indications from the first millennium Mycobacterium leprae molecular biotypes.
    • Donoghue H, Molto E, Spigelman M (2010). The paleoepidemiology of infectious diseases as elucidated by microbial biomarkers.
    • Donoghue HD, Lee OY-C, Minnikin DE, Besra GS, Taylor JH, Spigelman M (2010). Tuberculosis in Dr Granville's Mummy: a molecular re-examination of the first Egyptian mummy to be scientifically examined and given a medical diagnosis. Proceedings of the Royal Society B: Biological Sciences, 277(1678), 51 - 56. doi:10.1098/rspb.2009.1484

    2009

    • Donoghue HD, Hershkovitz I, Minnikin DE, Besra GS, Lee OY-C, Galili E, Greenblatt CL, Lemma E, Spigelman M, Kahila Bar Gal G (2009). Biomolecular archaeology of ancient tuberculosis: Response to "Deficiencies and challenges in the study of ancient tuberculosis DNA" by Wilbur et al.(2009). Journal of Archaeological Science, 36(12), 2797 - 2804. doi:10.1016/j.jas.2009.09.007
    • Donoghue HD, Holton J (2009). Intestinal tuberculosis. Current Opinion in Infectious Diseases, 22(5), 490 - 496. doi:10.1097/QCO.0b013e3283306712
    • Csóri Z, Donoghue HD, Marcsik A (2009). Leprosy in the 10th–13th century AD in Eastern Hungary. Annuaire Roumain d'Anthropologie, 46, 3 - 11.
    • Donoghue HD (2009). Human tuberculosis - an ancient disease, as elucidated by ancient microbial biomolecules. Microbes and Infection, 11(14-15), 1156 - 1162. doi:10.1016/j.micinf.2009.08.008
    • Monot M, Honoré N, Garnier T, Zidane N, Sherafi D, Paniz-Mondolfi A, Matsuoka M, Taylor GM, Donoghue HD, Bouwman A, Mays S, Watson C, Lockwood D, Khamispour A, Dowlati Y, Jianping S, Rea TH, Vera-Cabrera L, Stefani MM, Banu S, Macdonald MS, B R S, J S T, J H, K S, P B, P G, A R, J B, P J C, S T (2009). Comparative genomic and phylogeographic analysis of Mycobacterium leprae. Nature Genetics, 41(12), 1282 - 1291. doi:10.1038/ng.477
    • Drewe JA, Mwingi D, Donoghue HD, Cromie RL (2009). PCR analysis of presence and location of Mycobacterium avium in a constructed reed bed, with implications for avian tuberculosis control. FEMS Microbiology Ecology, 67(2), 320 - 328. doi:10.1111/j.1574-6941.2008.00618.x
    • Matheson CD, Vernon KK, Lahtil A, Fratpietrol R, Spigelman M, Gibson S, Greenblatt CL, Donoghue HD (2009). Molecular exploration of the first-century Tomb of the Shroud in Akeldama, Jerusalem. PLoS ONE, 4(12), e8319 - . doi:10.1371/journal.pone.0008319

    2008

    • Spigelman M, Pinhasi R, Donoghue HD, Erdal YS (2008). Golfer and tennıs elbow ın Byzantıne Turkey: epıcondylıtıs as an ımportant new occupatıon/actıvıty marker.
    • Lee O, Minnikin D, Besra G, Donoghue H, Taylor M, Roberts C (2008). Novel detection of leprosy in archaeological populations by analysis of mycolic acid lipid biomarkers.
    • Pulimood AB, Peter S, Rook GAW, Donoghue HD (2008). In situ PCR for Mycobacterium tuberculosis in endoscopic mucosal biopsies of intestinal tuberculosis and Crohn disease. American Journal of Clinical Pathology, 129, 846 - 851.
    • Donoghue HD (2008). Molecular palaeopathology of human infectious disease. In Pinhasi R, Mays S (Ed.), Advances in human palaeopathology (pp. 147 - 176). : John Wiley & Sons Ltd.
    • Spigelman M, Ikram S, Taylor J, Berger L, Donoghue HD, Lambert DM (2008). Mummification methods and animal mummies: Preliminary genetic and radiological studies of Ibis mummification in Egypt. In Peòa PA, Rodrìguez Martin C, Ramìrez Rodrìguez A (Ed.), Mummies and science. World mummies research (pp. 545 - 551). : Academia Canaria de la Historia [etc.].
    • Hershkovitz I, Donoghue HD, Minnikin DE, Besra GS, Lee OY-C, Gernaey AM, Galili E, Eshed V, Greenblatt CL, Lemma E, Kahila Bar-Gal G, Spigelman M (2008). Detection and molecular characterization of 9000-year-old Mycobacterium tuberculosis from a Neolithic settlement in the Eastern Mediterranean. PLoS ONE, 3(10), e3426 - e3426. doi:10.1371/journal.pone.0003426
    • Zink AR, Spigelman M, Schraut B, Greenblatt CL, Nerlich AG, Donoghue HD (2008). Paleopathology and paleoparasitology: molecular evidence for leishmaniasis in ancient Egypt and Upper Nubia. In Peòa PA, Rodrìguez Martin C, Ramìrez Rodrìguez A (Ed.), Mummies and science. World mummies research (pp. 357 - 362). : Academia Canaria de la Historia [etc.].
    • Spigelman M, Berger L, Pinhasi R, Donoghue HD, Chaplin S (2008). John Hunter's post-mortem examination of George Grenville (1712-1770). Bulletin of the Royal College of Surgeons of England, 90(10), 338 - 339. doi:10.1308/147363508X337163
    • Donoghue HD, Velemínky P, Likovsky J, Garcin V, Taylor GM (2008). Detection, characterisation and quantification of Mycobacterium leprae DNA from archaeological material.
    • Donoghue HD (2008). Palaeomicrobiology of tuberculosis. In Raoult D, Drancourt M (Ed.), Paleomicrobiology - Past Human Infections (pp. 75 - 97). : Springer-Verlag GmbH.
    • Kim MJ, Lee I, Spigelman M, Donoghue HD, Lee SD, Kim YS, Lim DS, Oh CS, Seo M, Park J-B, Shin DH (2008). Future prospects for the scientific investigations of the medieval human remains from the Joseon Dynasty in Korea. In Peòa PA, Rodrìguez Martin C, Ramìrez Rodrìguez A (Ed.), Mummies and science. World mummies research (pp. 649 - 653). : Academia Canaria de la Historia [etc.].
    • Spigelman M, Pap I, Szikossy I, Donoghue HD (2008). A case of Langerhans' cell histiocytosis and tuberculosis of an infant from the 18th century Hungary..
    • Pap I, Spigelman M, Szikossy I, Fletcher HA, Donoghue HD (2008). Tuberculosis in a 18th century population of Vác, Hungary.

    2007

    • McNerney R, Mallard K, Urassa HMR, Lemma E, Donoghue HD (2007). Colorimetric Phage-Based Assay for Detection of Rifampicin-Resistant Mycobacterium tuberculosis. Journal of Clinical Microbiology, 45(4), 1330 - 1332.

    2006

    • Pinhasi R, Foley R, Donoghue HD (2006). Reconsidering the antiquity of leprosy. Science, 312(5775), 846 - 846. doi:10.1126/science.312.5775.845a
    • Spigelman M, Pap I, Donoghue HD (2006). A death from Langerhans cell histiocytosis and tuberculosis in 18th Century Hungary - what palaeopathology can tell us today. Leukemia, 20(4), 740 - 742. doi:10.1038/sj.leu.2404103
    • Zink A, Spigelman M, Schraut B, Greenblatt C, Nerlich A, Donoghue H (2006). Leishmaniasis in ancient Egypt and Upper Nubia. Emerging Infectious Diseases, 12(10), 1616 - 1617.
    • Marcsik A, Fóthi E, Donoghue HD (2006). Leprosy or syphilis – a diferential diagnostic paleopathological problem.
    • Donoghue HD, Spigelman M (2006). Pathogenic microbial ancient DNA – a problem or an opportunity?. Proceedings of the Royal Society B: Biological Sciences, 273, 641 - 642. doi:10.1098/rspb.2005.3261
    • Molnár E, Marcsik A, Bereczki Z, Donoghue HD (2006). Pathological cases from the 7th century in Hungary.

    2005

    • Donoghue HD, Marcsik A, Matheson C, Vernon K, Nuorala E, Molto JE, Greenblatt CL, Spigelman M (2005). Co-infection of Mycobacterium tuberculosis and Mycobacterium leprae in human archaeological samples: a possible explanation for the historical decline of leprosy.. Proceedings of the Royal Society B: Biological Sciences, 272(1561), 389 - 394. doi:10.1098/rspb.2004.2966
    • Pulimood AB, Donoghue HD, Peter S, Rook GWA (2005). In situ polymerase chain reaction in the differentiation of intestinal tuberculosis from Crohn disease on mucosal biopsies.
    • Spigelman M, Greenblatt CL, Vernon K, Zylber MI, Sheridan SG, Van Gerven DP, Shaheem Z, Hansraj F, Donoghue HD (2005). Preliminary findings on the paleomicrobiological study of 400 naturally mummified human remains from upper Nubia. Journal of Biological Research, 80(1), 91 - 95.
    • Pulimood AB, Donoghue HD, Peter S, Rook G (2005). In situ polymerase chain reaction in the differentiation of intestinal tuberculosis from Crohn disease on mucosal biopsies.
    • Thapa N, Rook GAW, Donoghue H, Stanford JL (2005). Detection of intracellular TNF-α and IL-10 in CD4 and CD8 cells of patients with pulmonary tuberculosis using a flow cytometer. SAARC Journal of Tuberculosis, Lung Diseases & HIV/AIDS, 2(1), 10 - 14.

    2004

    • Donoghue HD, Spigelman M, Zias J, Gernaey-Child AM, Minnikin DE (2004). Demonstration of Mycobacterium tuberculosis complex DNA in calcified pleura from human remains excavated in Karkur. In Figueras P (Ed.), Horvat Karkur ïIllit. A Byzantine cemetery church in the Northern Negev (final report of the excavations 1989-1995) (pp. 316 - 320). : Ben-Gurion University of the Negev Press.
    • Donoghue HD, Spigelman M, Zias J, Gernaey-Child AM, Minnikin DE (2004). Demonstration of Mycobacterium tuberculosis complex DNA in calcified pleura from human remains excavated in Karkur. In Figueras P (Ed.), Horvat Karkur ¥Illit. A Byzantine cemetery church in the Northern Negev (final report of the excavations 1989-1995 (pp. 316 - 320). : Ben-Gurion University of the Negev Press.
    • Nuorala E, Donoghue HD, Spigelman M, Götherström A, Hårding B, Grundberg L, Alexandersen V, Leden I, Lidén K (2004). Diet and disease in Björned, a Viking-Early Medieval site in Northern Sweden. In (Ed.), Molecular Palaeopathology. Ancient DNA analyses of the bacterial diseases tuberculosis and leprosy (pp. - ). : Stockholm: Archaeological Research Laboratory.
    • Teschler-Nicola M, Spigelman M, Pinhasi R, Donoghue HD, Vernon K (2004). Molecular evidence of tuberculosis in the early mediaeval site of Gars/Thunau, Austria.
    • Nuorala E, Götherström A, Ahlström T, Donoghue HD, Spigelman M, Lidén K (2004). MTB complex DNA in a Scandinavian Neolithic passage grave. In (Ed.), Molecular Palaeopathology. Ancient DNA analyses of the bacterial diseases tuberculosis and leprosy (pp. - ). : Stockholm: Archaeological Research Laboratory.
    • Donoghue HD, Spigelman M, Greenblatt CL, Lev-Maor G, Kahila Bar-Gal G, Matheson C, Vernon K, Nerlich AG, Zink AR (2004). Tuberculosis: from prehistory to Robert Koch, as revealed by ancient DNA. The Lancet Infectious Diseases, 4(9), 584 - 592.
    • Donoghue HD, Marcsik A, Matheson C, Vernon K, Nuorala E, Spigelman M (2004). Mycobacterium tuberculosis and Mycobacterium leprae DNA in archaeological specimens with palaeopathology typical of leprosy.

    2003

    • Fletcher HA, Donoghue HD, Holton J, Pap I, Spigelman M (2003). Widespread occurrence of Mycobacterium tuberculosis DNA from 18th-19th century Hungarians. American Journal of Physical Anthropology, 120(2), 144 - 152. doi:10.1002/ajpa.10114
    • Spigelman M, Fletcher H, Holton J, Pap I, Matheson C, Donoghue HD (2003). The Hungarian mummy project.
    • Ubelaker DH, Spigelman M, Donoghue HD, Fletcher HA, Matheson C, Jones EB (2003). Evaluation of evidence for tuberculosis. In Ubelaker DH, Jones EB, Landers DB (Ed.), Human remains from Voegtly Cemetery, Pittsburgh, Pennsylvania (pp. 44 - 46). : Smithsonian Institution.
    • Spigelman M, Donoghue HD (2003). Palaeobacteriology with special reference to pathogenic mycobacteria. In Greenblatt C, Spigelman M (Ed.), Emerging Pathogens: Archaeology, Ecology and Evolution of Infectious Disease (pp. 175 - 188). : Oxford University Press.
    • Fletcher HA, Donoghue HD, Taylor GM, van der Zanden AGM, Spigelman M (2003). Molecular analysis of Mycobacterium tuberculosis DNA from a family of 18th century Hungarians. Microbiology, 149(1), 143 - 151. doi:10.1099/mic.0.25961

    2002

    • Spigelman M, Matheson C, Lev G, Greenblatt C, Donoghue HD (2002). Confirmation of the presence of Mycobacterium tuberculosis complex-specific DNA in three archaeological specimens. International Journal of Osteoarchaeology, 12(6), 393 - 401. doi:10.1002/oa.638
    • Spigelman M, Fletcher HA, Pap I, Donoghue HD (2002). The Hungarian Mummy Study 2002: Progress since DNA5 - Distribution and characteristics of Mycobacterium tuberculosis DNA in 18th century human remains.
    • Gibson S, Greenblatt C, Spigelman M, Gorski A, Donoghue HD, Vernon K, Matheson CD (2002). The Shroud Cave - a unique case study linking a closed loculus, a shroud and ancient mycobacteria.
    • Donoghue HD, Marcik A, Matheson C, Vernon K, Spigelman M (2002). Co-infection of Mycobacterium tuberculosis and Mycobacterium leprae in archaeological specimens.
    • Spigelman M, Donoghue HD (2002). The study of ancient DNA answers a palaeopathological question. In Roberts CA, Lewis ME, Manchester K (Ed.), The Past and Present of Leprosy: Archaeological, historical, palaeopathological and clinical approaches (pp. 287 - 296). : Archaeopress.
    • Donoghue HD, Gladykowska-Rzeczycka J, Marcsik A, Holton J, Spigelman M (2002). Mycobacterium leprae in archaeological samples. In Roberts CA, Lewis ME, Manchester K (Ed.), The Past and Present of Leprosy: Archaeological, historical, palaeopathological and clinical approaches (pp. 271 - 285). : Archaeopress.
    • Torres P, Holton J, Stanford JL, Donoghue HD (2002). Comparison of PCR primers for detection of M. leprae. In Roberts CA, Lewis ME, Manchester K (Ed.), The Past and Present of Leprosy: Archaeological, historical, palaeopathological and clinical approaches (pp. 63 - 66). : Archaeopress.
    • Lev-Maor G, Blondiaux J, Spigelman M, Donoghue H, Rothschild B, Zias J, Kahila G, Matheson C, Skuce R, Greenblatt CL (2002). Ancient tuberculosis: problems of diagnosis and characterization.

    2001

    • Rothschild BM, Martin LD, Lev G, Bercovier H, Bar-Gal GK, Greenblatt C, Donoghue H, Spigelman M, Brittain D (2001). Mycobacterium tuberculosis complex DNA from an extinct bison dated 17,000 years before the present. Clinical Infectious Diseases, 33(3), 305 - 311. doi:10.1086/321886
    • Spigelman M, Donoghue HD, Fletcher HA (2001). Cure from the crypt.
    • Spigelman M, Donoghue HD (2001). Brief communication: unusual pathological condition in the lower extremities of a skeleton from ancient Israel. American Journal of Physical Anthropology, 114(1), 92 - 93. doi:10.1002/1096-8644(200101)114:1<92::AID-AJPA1008>3.0.CO;2-V
    • Donoghue HD, Holton J, Spigelman M (2001). PCR primers that can detect low levels of Mycobacterium leprae DNA. Journal of Medical Microbiology, 50(2), 177 - 182.

    2000

    • Ubelaker DH, Jones EB, Donoghue HD, Spigelman M (2000). Skeletal and Molecular Evidence for Tuberculosis in a Forensic Case. Anthropologie – International Journal of the Science of Man, 38(2), 193 - 200.

    1999

    • Pap I, Józsa L, Repa I, Bajzik G, Lakhani SR, Donoghue HD, Spigelman M (1999). 18-19th century tuberculosis in naturally mummified individuals (Vác, Hungary). In Pälfi G, Dutour O, Deák J, Hutás I (Ed.), Tuberculosis Past and Present (pp. 421 - 428). : Golden Book Publisher Ltd., Tuberculosis Foundation.
    • Spigelman M, Donoghue HD (1999). Mycobacterium tuberculosis DNA in archaeological specimens'. In Pälfi G, Dutour O, Deák J, Hutás I (Ed.), Tuberculosis Past and Present (pp. 353 - 360). : Golden Book Publisher Ltd., Tuberculosis Foundation.
    • Street S, Donoghue HD, Neild GH (1999). Tropheryma whippelii DNA in saliva of healthy people. The Lancet, 354(9185), 1178 - 1179. doi:10.1016/S0140-6736(99)03065-2
    • Donoghue HD, Neild GH, Street S (1999). Presence of Tropheryma whippelii-specific DNA in saliva from healthy individuals..
    • Donoghue HD, Uberlaker DH, Spigelman M (1999). The use of palaeomicrobiological techniques in a current forensic case. In Pälfi G, Dutour O, Deák J, Hutás I (Ed.), Tuberculosis Past and Present (pp. 363 - 368). : Golden BookPublisher Ldt., Tuberculosis Foundation.

    1998

    • Donoghue HD, Spigelman M, Lakhani SR, Pap I (1998). Mycobacterium tuberculosis complex DNA in naturally mummified indibiduals from 18th century Vac, Hungary.
    • Donoghue HD, Spigelman M, Zias J, Gernaey-Child AM, Minnikin DE (1998). Mycobacterium tuberculosis complex DNA in calcified pleura from remains 1400 years old. Letters in Applied Microbiology, 27(5), 265 - 269. doi:10.1046/j.1472-765X.1998.00436.x

    1997

    • Khosravi AD, Stanford JL, Donoghue HD, Rook GA (1997). Variation within Mycobacterium scrofulaceum. Journal of Applied Microbiology, 83(5), 596 - 602.
    • Donoghue HD, Overend E, Stanford JL (1997). A longitudinal study of environmental mycobacteria on a farm in south-west England. Journal of Applied Microbiology, 82(1), 57 - 67.

    1995

    • Rafi A, Donoghue HD, Stanford JL (1995). Application of the polymerase chain reaction for the detection of Mycobacterium leprae DNA in specimens from treated leprosy patients. International Journal of Leprosy and Other Mycobacterial Diseases, 63(1), 42 - 47.

    1994

    • Rafi A, Spigelman M, Lemma E, Donoghue H, Zias J (1994). Mycobacterium leprae DNA from ancient bone detected by PCR. The Lancet, 343(8909), 1360 - 1361.
    • Rafi A, Spigelman M, Stanford J, Lemma E, Donoghue H, Zias J (1994). DNA of Mycobacterium leprae detected by PCR in ancient bone. International Journal of Osteoarchaeology, 4, 287 - 290.

    1991

    • Donoghue HD, Perrons CJ (1991). Effect of nutrients on defined bacterial plaques and Streptococcus mutans C67-1 implantation in a model mouth.. Caries Research, 25(2), 108 - 115.

    1990

    • Donoghue HD (1990). Can the colonisation resistance of the oral microflora be enhanced?.
    • Perrons CJ, Donoghue HD (1990). Colonization resistance of defined bacterial plaques to Streptococcus mutans implantation on teeth in a model mouth.. Journal of Dental Research, 69(2), 483 - 488.

    1988

    • Donoghue HD, Perrons CJ (1988). Establishment of defined mixed bacterial plaques on teeth in a laboratory microcosm (artificial mouth). Microbial Ecology in Health and Disease, 1, 193 - 200.
    • Donoghue HD, Perrons CJ (1988). Accumulation of streptococci on teeth in a laboratory microcosm (artificial mouth). Microbial Ecology in Health and Disease, 1, 123 - 130.

    1987

    • Donoghue H (1987). A mouthful of microbial ecology. New Scientist, 113(1548), 61 - 65.
    • Donoghue HD, Hudson DE, Perrons CJ (1987). Effect of the lactoperoxidase system on streptococcal acid production and growth.. Journal of Dental Research, 66(2), 616 - 618. doi:10.1177/00220345870660024701

    1986

    • Hudson DE, Donoghue HD, Perrons CJ (1986). A laboratory microcosm (artificial mouth) for the culture and continuous pH measurement of oral bacteria on surfaces.. Journal of Applied Bacteriology, 60(4), 301 - 310.

    1985

    • Donoghue HD, Hudson DE, Perrons CJ (1985). Initial growth and acid production by streptococci on tooth surfaces.
    • Donoghue HD, Perrons CJ, Hudson DE (1985). The role of H2O2 and the lactoperoxidase-SCN(-)-H2O2 system on the interaction between two bacteria originating from human dental plaque, Streptococcus rattus (mutans) BHT and Streptococcus mitior LPA-1, grown on human teeth in an artificial mouth.. Archives of Oral Biology, 30(7), 519 - 523.
    • Perrons CJ, Donoghue HD (1985). Acid production by A. viscosus WVU627 AND A. naeslundii TF-11 - effect of the salivary peroxidase system.

    1984

    • Hudson DE, Donoghue HD, Perrons CJ (1984). Continuous pH measurement of Streptococcus mutans BHT and Streptococcus mitior LPA-1 grown in an artificial mouth.

    1983

    • Donoghue HD (1983). Book review: Oral microbiology and infectious disease. 2nd student edition. Edited by George S. Schuster. Baltimore: Williams and Wilkins. 1983.. British Dental Journal, 155(4), 114 - 114.
    • Donoghue HD, Hudson DE, Perrons CJ, Dibdin GH, Rapson G, Shellis RP, Wilson CM (1983). Effect of inoculation sequence and nutrients upon Streptococcus mutans BHT and Streptococcus mitior LPA-1 growing on human teeth in an artificial mouth.. Journal of Applied Bacteriology, 54(1), 23 - 29.
    • Hudson DE, Donoghue HD, Perrons CJ (1983). The role of lactoperoxidase in the interaction between Streptococcus mutans BHT and Streptococcus mitior LPA-1.
    • Donoghue HD, Perrons CJ, Hudson DE (1983). Streptococcal interactions in a model mouth.

    1982

    • Stack MV, Donoghue HD, Tyler JE (1982). Differentiation of Streptococcus mutans serotypes by discriminatory analysis of pyrolysis-gas-liquid chromatography data. Journal of Analytical and Applied Pyrolysis, 3(3), 221 - 227. doi:10.1016/0165-2370(82)80010-7
    • Donoghue HD, Perrons CJ, Hudson DE (1982). Effect of the lactoperoxidase thiocyanate hydrogen peroxide antimicrobial system on streptococci in an artifical mouth.

    1981

    • Stack MV, Donoghue HD, Tyler JE (1981). Discrimination among oral streptococci.

    1980

    • Donoghue HD, Dibdin GH, Shellis RP, Rapson G, Wilson CM (1980). Effect of nutrients upon Streptococcus mutans BHT and Streptococcus mitior LPA-1 growing in pure and mixed culture on human teeth in an artificial mouth. Journal of Applied Bacteriology, 49(2), 295 - 304. doi:10.1111/j.1365-2672.1980.tb05128.x

    1979

    • Donoghue HD, Rapson G, Wilson CM (1979). Interactions of Streptococcus mutans and Streptococcus mitior in an artificial mouth.

    1978

    • Stack MV, Donoghue HD, Tyler JE (1978). Discrimination between oral streptococci by pyrolysis gas-liquid chromatography. Applied and Environmental Microbiology, 35(1), 45 - 50.
    • Donoghue HD, Rapson G, Wilson CM (1978). Effect of inoculation sequence on numbers of Streptococcus mutans and Streptococcus mitior recovered from tooth surfaces after growth in an artificial mouth.

    1977

    • Newman HN, Donoghue HD (1977). Ultrastructure and biology of a cariogenic Streptococcus and its non-cariogenic mutant grown in batch culture with excess glucose or sucrose.
    • Donoghue HD, Rapson G, Wilson CM (1977). Effect of diet on growth of Streptococcus mutans and S. mitior in an artificial mouth.
    • Stack MV, Donoghue HD, Tyler JE, Marshall M (1977). Comparison of oral streptococci by pyrolysis GLC.
    • Donoghue HD (1977). Production of megacins C and Cx – presumptive evidence of extrachromosomal control. Antimicrobial Agents and Chemotherapy, 11(1), 34 - 37.

    1976

    • Newman HN, Donoghue HD (1976). Response of cariogenic organisms to sucrose.
    • Donoghue H (1976). Survival of Streptococcus mutans C67-1 and C67-25 in batch culture.
    • Newman HN, Donoghue HD, Britton AB (1976). Effect of glucose and sucrose on survival in batch culture of Streptococcus mutans C67-1 and a non-cariogenicc mutant C67-25: morphological studies. Microbios, 15(60), 113 - 125.
    • Donoghue HD, Newman HN (1976). Effect of glucose and sucrose on survival in batch culture of Streptococcus mutans C67-1 and a non=cariogenic mutant, C67-25. Infection and Immunity, 13(1), 16 - 21.

    1975

    • Donoghue HD, Tyler JE (1975). Antagonisms amongst streptococci from the human oral cavity. Archives of Oral Biology, 20(5-6), 381 - 387. doi:10.1016/0003-9969(75)90031-X
    • Donoghue HD, Tyler JE (1975). Role of lactic and acetic acids in microbial antagonism.

    1974

    • Stack MV, Donoghue HD, Tyler JE, Marshall M (1974). Factors affecting the composition of oral streptococci as shown by pyrolysis-gas chromatography.
    • Donoghue HD (1974). Composition of dental plaque from 8 sites in the mouth of a 10-year-old girl. Journal of Dental Research, 53(5), 1289 - 1293. doi:10.1177/00220345740530053601
    • Donoghue HD (1974). Inhibition of plaque bacteria by microbial production of hydrogen peroxide.

    1972

    • Donoghue HD (1972). Properties and comparative starch-gel electrophoresis of megacins from several Bacillus megaterium strains. Journal of General Microbiology, 72(3), 473 - 483.

    • Donoghue HD, Taylor GM, Pinhasi R, Marcsik A, Molnár E, Teschler-Nicola M, Erdal YS, Spigelman M (). Who brought leprosy into central Europe?.
    • Donoghue HD, Lee OYC, Minnikin DE, Gernaey AM, Greenblatt C, Spigelman M (). Molecular microbiology in Irtu Senu. In Taylor J, Harer B (Ed.), Lord Granville's Egyptian Mummy (pp. - ). : British Museum Press.