Prof Peter Delves

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Name: Peter Delves Email: p.delves@ucl.ac.uk
Title: Prof Tel: 020 3108 2135
Department: Div of Infection & Immunity Fax:
Position: Professor of Immunology Address: Department of Immunology, UCL, Cruciform Building, London, WC1E 6BT
Research Domain: Cancer, Infection, Immunology & Inflammation, Personalised Medicine Web Page:  

Profile

Research Description

The development of vaccines based upon reproductive hormones, particularly human chorionic gonadotropin (hCG), which have utility both as immmunological contraceptives, and as anti-cancer therapeutics.

For contraception the vaccine formulation should elicit neutralising antibodies in the absence of cytotoxic T lymphocyte (CTL) responses. The 'pregnancy-specfic' hormone hCG is also aberrantly expressed in a number of different malignancies. In these cases the beta-chain is often expresssed in the absence of the alpha-chain. Anti-cancer vaccines based upon hCG may benefit from being able to elicit CTL responses in addition to antibody responses. A number of mutated hCG-beta molecules have been generated, one of which (hCGbR68E)has an improved immunogenic profile compared to the wild-type sequence.


Research Activities

Human chorionic gonadotropin vaccines

Education Description

Vice Dean (Education) Faculty of Medical Sciences. Editor of 2 encyclopedias (Encyclopedia of Immunology [Elsevier] and Encyclopedia of Life Sciences [Wiley-Blackwell]). Author or co-author of several textbooks and laboratory manuals. Particularly interested in innovation in web-base learning. Responsible for all taught course provision at both undergraduate and postgraduate level within the Division of Infection and Immunity. Course director of several undergraduate and postgraduate courses, plus extensive teaching experience at all levels both in the UK and overseas.

UCL Collaborators

External Collaborators

Publications

    2015

    • Delves PJ, Martin SJ, Burton DR, Roitt IM (2015). Essential Immunology.
    • Delves PJ, Martin SJ, Burton DR, Roitt IM (2015). Essential Immunology.

    2014

    • Battista J, Bynum W, Cooper D, Delves PJ, Harper D, Jansson R, Kehrer-Sawatzki H, Levitan I, Melino G, Phillips G, Roberts K, Tickle C, Zheng YE (2014). Encyclopedia of Life Sciences. www.els.net. Continuously updated electronic encyclopedia..
    • Delves PJ (2014). Allergic, autoimmune and other hypersensitivity disorders.. In (Ed.), The Merck Manual: Professional edition. (pp. - ). : Merck & Co, Inc..
    • Delves PJ (2014). Biology of the immune system. In (Ed.), The Merck Manual: Professional edition (pp. - ). : Merck & Co, Inc..
    • Delves PJ (2014). Innate and adaptive systems of immunity.. In Rose NR, Mackay IR (Ed.), The Autoimmune Diseases (pp. 53 - 68). : Elsevier.

    2013

    • Delves PJ (2013). Biology of the immune system. In (Ed.), The Merck Manual: Home Edition. (pp. - ). : Merck & Co, Inc..

    2011

    • DELVES P (2011). Teaching immunology: A view from the coalface..
    • DELVES P (2011). Immunocontraceptive Vaccination - A Success Story for Therapeutic Vaccines (A 416).

    2010

    • Iles RK, Delves PJ, Butler SA (2010). Does hCG or hCGβ play a role in cancer cell biology?. Mol Cell Endocrinol, 329(1-2), 62 - 70. doi:10.1016/j.mce.2010.07.014
    • Delves PJ (2010). Immunocontraceptive vaccination: a success story for therapeutic vaccines.

    2008

    • McBride JD, Gabriel FG, Fordham J, Kolind T, Barcenas-Morales G, Isenberg DA, Swana M, Delves PJ, Lund T, Cree IA, Roitt IM (2008). Screening autoantibody profiles in systemic rheumatic disease with a diagnostic protein microarray using a filtration assisted Nanodot Array Luminometric ImmunoAssay (NALIA).. Clinical Chemistry, 54, 883 - 890. doi:10.1373/clinchem.2007.098418
    • Delves PJ (2008). Immunological contraception: Can gonadotropins still be considered viable candidates for anti-fertility vaccines?.
    • Delves PJ (2008). Global Day of Immunology 2008.. Immunology News, 15(3), 18 - 19.

    2007

    • Atlas RM, Bynum WF, Cox MM, Delves PJ, Hirst MC, Levitan IB, Matsudaira PT, Phillips G, Roberts K, Silvertown JW, Wood BAE (2007). Encyclopedia of Life Sciences. Print version (26 volumes).
    • Delves P (2007). Immune Response. In Fink G (Ed.), Encyclopedia of Stress (pp. 462 - 469). : Elsevier.
    • Ghali L, Iles RK, Lund T, Naase M, Roitt IM, Delves PJ (2007). Is human chorionic gonadotropin (hCG) truly a tumor-associated antigen in non-germ cell tumors?.
    • (2007). Encyclopedia of Life Sciences. doi:10.1002/047001590X
    • Delves PJ, Iles RK, Roitt IM, Lund T (2007). Designing a new generation of anti-hCG vaccines for cancer therapy.. Molecular and Cellular Endocrinology, 262, 276 - 281.

    2006

    • Delves P (2006). CD antigens. In Battista J, Bynum W, Cooper D, Cox M, Delves P, Harper D, Jansson R, Levitan I, Melino G, Phillips G, Roberts K, Tickle C, Wood B, Zheng Y (Ed.), Encyclopedia of Life Sciences (pp. 1 - 21). : Wiley. doi:10.1002/9780470015902.a0000924.
    • Delves PJ, Martin SJ, Burton DR, Roitt IM (2006). Essential Immunology, 11th edn.

    2005

    • Lydyard PM, Delves PJ (2005). 10 years of higher education support for Georgia.. Immunology News, 12(4), 23 - 25.
    • Rabson A, Roitt IM, Delves PJ (2005). Really Essential Medical Immunology, 2nd edition.
    • Roitt IM, Lund T, Delves PJ (2005). Developments in Vaccine Design.
    • Porakishvili N, Dalla Chiesa M, Delves P J LT, Roitt IM (2005). Transient and stable expression of the beta subunit of human chorionic gonadotropin in mammalian cell lines resulted in the detection of a low yield of the protein.. Trans-Caucasian Journal of Biomedical Sciences, 1, 10 - 16.
    • Christiansen OB, Andersen A, Bosch E, Daya S, Delves PJ, Hviid TV, Kutteh WH, Laird SM, Li T, van der Ven K (2005). Evidence-based investigations and treatments of recurrent pregnancy loss. Fertility and Sterility, 83, 821 - 839. doi:10.1016/j.fertnstert.2004.12.018
    • Christiansen OB, Daya S, Bosch E, Delves PJ (2005). Evidence–Based Investigations and Treatments of Recurrent Pregnancy Loss: Reply of the Authors.. Fertility and Sterility, 84, 813 - 814.
    • Christiansen OB, Daya S, Bosch E, Delves PJ (2005). Weighing the evidence-metaquality and immunologic problems in in vitro fertilization cycles? Reply. FERTIL STERIL, 84(3), 813 - 814. doi:10.1016/j.fertnstert.2005.06.002
    • Delves PJ, Roitt IM (2005). Vaccines for the control of reproduction: status in mammals, and aspects of comparative interest. Developments in Biologicals, 121, 265 - 273.
    • Delves PJ (2005). Immunocontraception – Is it feasible in humans?. American Journal of Reproductive Immunology, 54, 165 - 166.
    • Charrel-Dennis M, Terrazzini N, McBride JD, Kaye P, Martensen PM, Justesen J, Berger P, Lapthorn A, Kelly C, Roitt IM, Delves PJ, Lund T (2005). The human chorionic gonadotropin-beta arginine68 to glutamic acid substitution fixes the conformation of the C-terminal peptide.. Molecular Endocrinology, 19, 1803 - 1811. doi:10.1210/me.2004-0109
    • Delves PJ, Kvirkvelia N, McBride JD, Hannesdottir SG, Fraser HM, Sharpe RM, Millar RP, Singh M, Iyer KS, Meloen RH, Roitt IM, Lund T (2005). Efficacy of RIBI adjuvant for GnRH vaccines in post-pubescent rats.

    2004

    • Hannesdottir SG, Han X, Lund T, Singh M, Ven der Zee R, Roitt IM, Delves PJ (2004). Changes in the reproductive system of male mice immunized with a GnRH-analogue conjugated to mycobacterial hsp70. Reproduction, 128(3), 365 - 371. doi:10.1016/j.vaccine.2003.12.002
    • Terrazzini N, Hannesdottir S, Delves PJ, Lund T (2004). DNA immunization with plasmids expressing hCGbeta-chimeras. Vaccine, 22, 2146 - 2153. doi:10.1016/vaccine.2003.12.002
    • Delves P (2004). Vaccine Protocols. Robinson,A., Hudson,M.J., Cranage,M.P. (eds). 2nd Edn. Humana Press.. Immunology News, 11, 324 - .
    • Charrel-Dennis M, Jackson AM, Lund T, Lapthorn AJ, Berger P, Roitt IM, Delves PJ (2004). The major hormone-specific discontinuous epitopes on human chorionic gonadotrophin. Journal of Molecular Endocrinology, 32(2), 571 - 581.
    • Delves PJ (2004). How far from a hormone-based contraceptive vaccine?. Journal of Reproductive Immunology, 62(1-2), 69 - 78. doi:10.1016/j.jri.2003.08.003
    • Hannesdóttir SG, Han X, Lund T, Singh M, Van Der Zee R, Roitt IM, Delves PJ (2004). Changes in the reproductive system of male mice immunized with a GnRH-analogue conjugated to mycobacterial hsp70.. Reproduction, 128(3), 365 - 371. doi:10.1530/rep.1.00108

    2003

    • Delves PJ, McBride JD, Porakishvili N, Chikadze N, Janikashvili N, Kvirkvelia N, Charrel M, Martensen P, Justensen J, Chiesa MD, Laylor R, Jackson A, Lund T (2003). Development of an antifertility vaccine based on a mutated human chorionic gonadotropin beta-chain. Recent Research Developments in Immunology, 5, 283 - 293.
    • Delves PJ (2003). Hormone-based contraceptive vaccines..
    • Delves PJ, Sargent I (2003). 15th European Immunology Congress: Hippokration Congress on Reproductive Immunology, Rhodes, Greece, June 4-6 2003..
    • Kvirkvelia N, Page M, McBride JD, Porakishvili N, Lund T, Roitt IM, Delves PJ (2003). The use of Hepatitis B core antigen particles as a presentation scaffold for a peptide-based contraceptive vaccine..

    2002

    • Delves PJ (2002). The influenza vaccine and its composition..
    • Delves PJ (2002). Autoimmune disease and pregnancy..
    • Kvirkvelia N, Vojnovic I, Warner TD, Athie-Morales V, Free P, Rayment N, Chain BM, Rademacher T, Lund T, Roitt IM, Delves PJ (2002). Placentally-derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells. Clinical and Experimental Immunology, 127(2), 263 - 269.
    • Hannesdottir SG, Lund T, Delves PJ, Singh M, Van der Zee R, Roitt IM (2002). Effect on the reproductive system in male mice immunized with a GnRH-analogue conjugated to hsp70..
    • Porakishvili N, Chiesa MD, Chikadze N, Martensen P, Justesen J, Lund T, Delves PJ, Roitt IM (2002). Elimination of luteinizing hormone cross-reactive epitopes from human chorionic gonadotropin. Vaccine, 20(16), 2053 - 2059. doi:10.1016/S0264-410X(02)00051-8
    • Delves PJ, Lund T, Roitt IM (2002). Future prospects for vaccines to control fertility. Trends in Immunology, 23(4), 220 - 221. doi:10.1016/S1471-4906(02)02183-X
    • Porakishvili N, Fordham JLA, Charrel M, Delves PJ, Lund T, Roitt IM (2002). A low budget luminometer for sensitive chemiluminescent immunoassays.. In (Ed.), Luminescence Biotechnology: Instruments and Applications (pp. - ). : CRC Press.
    • Delves PJ (2002). The development of contraceptive vaccines. Expert Opinion on Investigational Drugs, 11(9), 1225 - 1237.
    • Delves PJ, Lund T, Roitt IM (2002). Antifertility vaccines. Trends in Immunology, 23(4), 213 - 219. doi:10.1016/S1471-4906(02)02182-8
    • Delves PJ (2002). Prion diseases..

    2001

    • Saleem A, Porakishvili N, Delves PJ, Lydyard PM (2001). Galectin-1 (GL-1) induces apoptosis of B-chronic lymphocytic leukaemic (B-CLL) cells..
    • Dalla Chiesa M, Martensen PM, Simmons C, Porakishvili N, Justesen J, Dougan G, Roitt IM, Delves PJ, Lund T (2001). Refocusing of B-cell responses following a single amino acid substitution in an antigen. Immunology, 103, 172 - 178.
    • Delves P (2001). Diagnosis of autoimmune disease..
    • Delves P (2001). Treatment of autoimmune disease..
    • Roitt IM, Delves PJ (2001). Essential Immunology, 10th Edn..
    • Kvirkvelia N, Vojnovic I, Warner TD, Athie-Morales V, Free P, Rayment N, Chain BM, Rademacher TW, Lund T, Roitt IM, Delves PJ (2001). Low molecular weight heat stable immunosuppressive material from placenta inhibits IL-2-dependent proliferation of CTLL-2 cells via the EP4 receptor..
    • Delves PJ (2001). New insights in glycoimmunology. Biotechnology News International, 6, 8 - 10.

    2000

    • Delves PJ, Roitt IM (2000). The immune system. First of two parts. New England Journal of Medicine, 343(1), 37 - 49.
    • Delves PJ (2000). Investigating AIDS-related diseases..
    • Kvirkvelia N, Warner TD, Vojnovic I, Rayment NB, Free PF, Lund T, Roitt IM, Delves PJ (2000). Prostaglandin E2 is the major low molecular weight heat stable immunosuppressive agent secreted by short term cultures of human placenta..
    • Delves PJ, Roitt IM (2000). Advances in immunology: The immune system - Second of two parts.. NEW ENGL J MED, 343(2), 108 - 117.
    • Porakishvili N, Chikadze N, Dalla Chiesa M, Martensen PM, Justensen J, Roitt IM, Delves PJ, Lund T (2000). Antibodies to mutant protein of human chorionic gonadotropin beta-subunit (hCGbeta) do not cross-react with human luteinising hormone (hLH)..
    • Delves PJ (2000). Third Congress of the European Society for Reproductive and Developmental Immunology. Poznan, Poland. 19th-21st September 2000..
    • Delves PJ (2000). Vaccines..
    • Jeddi PA, Lydyard PM, Delves PJ (2000). beta4Gal-T1 expression following prolactin stimulation of B-cells..
    • Porakishvili N, Fordham JL, Charrel M, Delves PJ, Lund T, Roitt IM (2000). A low budget luminometer for sensitive chemiluminescent immunoassays. Journal of Immunological Methods, 234(1-2), 35 - 42.
    • Delves PJ, Roitt IM (2000). The immune system. Second of two parts. New England Journal of Medicine, 343(2), 108 - 117.

    1999

    • Jeddi P, Keusch J, Lydyard PM, Bodman-Smith KB, Cheshunt MS, Wofsy D, Hirota H, Taga T, Delves PJ (1999). The effect on immunoglobulin glycosylation of altering in vivo production of imunoglobulin G. Immunology, 98, 475 - 480.
    • Delves PJ (1999). 10th International Congress of Immunology, New Delhi 1st-6th November 1998..
    • Laylor R, Porakishvili N, de Souza JB, Playfair JHL, Delves PJ, Lund T (1999). DNA vaccination favours memory rather than effector B cell responses. Clinical and Experimental Immunology, 117, 106 - 112.
    • Kvirkvelia N, Free P, Lund T, Roitt IM, Delves PJ (1999). Differential effects on lymphocyte cell lines of supernatants from short term cultures of human placenta..
    • Delves PJ (1999). Antibody fusion proteins. SM Chamov and A Ashkenzi. Wiley-Liss. 6, 239.. , 6(1), 34 - .
    • Porakishvili N, Dalla Chiesa M, Lund T, Delves PJ, Roitt IM (1999). Dramatically decreased cross-reactivity with human leuteinizing hormone of a mutant molecule of human chorionic gonadatropin beta chain.
    • Delves PJ (1999). How did AIDS arise?. Trans-Caucasian Journal of Immunology, 1, 48. - .
    • Chaudri ZN, Bartlet-Jones M, Panaytou G, Klonisch T, Roitt IM, Lund T, Delves PJ (1999). Dual specificity antibodies using an oligonucleotide bridge. FEBS Letters, 450, 23 - 26.
    • Chaudri ZN, Bartlet-Jones M, Panayotou G, Klonisch T, Roitt IM, Lund T, Delves PJ (1999). Dual specificity antibodies using a double-stranded oligonucleotide bridge.. FEBS Lett, 450(1-2), 23 - 26.

    1998

    • Delves PJ (1998). Autoimmunity. In Delves PJ, Roitt IM (Ed.), Encyclopedia of Immunology (pp. 292 - 296). : Academic Press.
    • Lund T, Delves PJ (1998). Immunological analysis of epitopes on human chorionic gonadotropin. Reviews in Reproduction, 3, 71 - 76.
    • Laylor R, Porakishvili N, de Souza JB, Dalla C, Playfair JHL, Delves PJ, Lund T (1998). Priming for an immune response to human chorionic gonadotropin beta chain using DNA vaccination.
    • Porakishvili N, Dalla Chiesa M, Justensen J, Martensen P, Chaudri Z, Roitt IM, Delves PJ, Lund T (1998). Antibodies induced by mutants of human chorionic gonadotropin-beta (hCGbeta) have greatly decreased cross-reactivity with luteinizing hormone (LH)..
    • Keusch J, Lydyard PM, Delves PJ (1998). The effect on IgG glycosylation of altering beta1,4-galactosyltransferase-1 activity in B cells. Glycobiology, 8, 1215 - 1220.
    • Chaudri ZN, Bartlet-Jones M, Roitt IM, Lund T, Delves PJ (1998). Dual-epitope specific antibodies using an oligonucleotide bridge.
    • Keusch J, Panayotou G, Malissard M, Berger EG, Appert HE, Lydyard PM, Delves PJ (1998). Antibody recognition of epitopes on wild-type and mutant beta-(1-->4)-galactosyltransferase-1.. Carbohydr Res, 313(1), 37 - 48.
    • Delves PJ, Lund T, Roitt IM (1998). Epitope-focused vaccines.. In Talwar GP, Nath I, Ganguly NK, Rao KVS (Ed.), Proc. 10th International Congress of Immunology, (pp. 1363 - 1368). : Monduzzi Editore..
    • Keusch J, Lydyard PM, Delves PJ (1998). B lymphocyte galactosyltransferase protein levels in normal individuals and in patients with rheumatoid arthritis. Glycoconjugate Journal, 15, 587 - 594.
    • Porakishvili N, Jackson AM, de Souza JB, Della C, Roitt IM, Delves PJ, Lund T (1998). Epitopes of human chorionic gonadotropin (hCG) and their relationship to immunogenicity and cross-reactivity of beta chain mutants. American Journal of Reproductive Immunology, 40, 210 - 214.
    • Delves PJ (1998). Immunoglobulin gene superfamily. In Delves PJ, Roitt IM (Ed.), Encyclopedia of Immunology (pp. 1319 - 1323). : Academic Press.
    • Peet NM, McKeating JA, de Souza JB, Roitt IM, Delves PJ, Lund T (1998). Elimination of the immunodominant B cell epitopes on the V3 loop of HIV gp120. Virology, 251, 59 - 70.
    • Delves PJ (1998). The role of glycosylation in autoimmune disease. Autoimmunity, 27, 239 - 253.
    • Keusch J, Lydyard PM, Berger EG, Delves PJ (1998). B lymphocyte galactosyltransferase protein levels in normal individuals and in patients with rheumatoid arthritis.. Glycoconj J, 15(11), 1093 - 1097.
    • Lund T, Delves PJ (1998). Immunological analysis of epitopes on hCG.. Rev Reprod, 3(2), 71 - 76.
    • Peet NM, McKeating JA, de Souza JB, Roitt IM, Delves PJ, Lund T (1998). The effect of low-profile serine substitutions in the V3 loop of HIV-1 gp120 IIIB/LAI on the immunogenicity of the envelope protein.. Virology, 251(1), 59 - 70. doi:10.1006/viro.1998.9392
    • Delves PJ (1998). The Leucocyte Antigen Factsbook. Second edition. Neil Barclay, A., Brown, M.H., Alex Law, S.K., McKnight, A.J., Tomlinson, M.G., Anton van der Merwe,P. Academic Press. 1998. 5, 45.. Immunology News., 5(3), 38 - .
    • Delves PJE-I-C, Roitt IMCE (1998). Encyclopedia of Immunology, 2nd Edn..
    • Keusch J, Panayotou G, Malissard M, Berger EG, Appert HE, Lydyard PM, Delves PJ (1998). Antibody recognition of epitopes on wild-type and mutant beta1, 4-galactosyltransferase-1. Carbohydrate Research, 311, 1 - 12.

    1997

    • Delves PJ (1997). Microorganisms and autoimmune diseases. Friedman, H., Rose,N.R., Beninelli,M. Plenum.. Molecular Medicine Today., 4, 195 - 196.
    • Delves PJ (1997). Antibody Production.
    • Delves PJ, Lund T, Roitt IM (1997). Can epitope-focused vaccines select advantageous immune responses?. Molecular Medicine Today, 3, 55 - 60.
    • Keusch J, Lydyard PM, Delves PJ (1997). Sense/antisense-mediated alteration of beta1,4-galactosyltransferase expression in human B lymphocytes..
    • Peet NM, McKeating JA, Ramos B, Klonisch T, de Souza JB, Delves PJ, Lund T (1997). Comparison of nucleic acid and protein immunization for induction of antibodies specific for HIV-1 gp120. Clinical and Experimental Immunology, 109, 226 - 232.
    • Jeddi PA, Keusch J, Lydyard PM, Delves PJ (1997). The stability of lymphocytic beta1-4,-galactosyltransferase expression during pregnancy and lactation. Scandinavian Journal of Immunology, 45, 145 - 150.
    • Roitt IM, Delves PJ (1997). New modified beta-human chorionic gonadotropin proteins; hCG protein engineering and expression in a mammalian or microorganism cell, for use as a contraceptive and antitumor recombinant vaccine, or a nucleic acid vaccine..

    1996

    • Klonisch T, Panayotou G, Edwards P, Jackson AM, Berger P, Delves PJ, Lund T, Roitt IM (1996). Enhancement in antigen binding by a combination of synergy and antibody capture.. Immunology, 89, 165 - 171.
    • Jackson AM, Klonisch T, Lapthorn AJ, Berger P, Isaacs NW, Delves PJ, Lund T, Roitt IM (1996). Identification and selective destruction of shared epitopes in human chorionic gonadotropin beta subunit.. Journal of Reproductive Immunology, 31, 21 - 36.
    • Delves PJ (1996). The regulation of beta1,4-galactosyltransferase expression and activity.. Trends in Glycoscience and Glycotechnology, 8, 377 - 389.
    • Jeddi PA, Bodman-Smith KB, Lund T, Lydyard PM, Mengle-Gaw L, Isenberg DA, Youinou P, Delves PJ (1996). Agalactosyl IgG and beta1,4-galactosyltransferase gene expression in rheumatoid arthritis patients and in the arthritis-prone MRL lpr/lpr mouse.. Immunology, 87, 654 - 659.
    • Berger P, Bidart JM, Delves PJ, Dirnhofer S, Hoermann R, Isaacs N, Jackson A, Klonisch T, Lapthorn A, Lund T, Mann K, Roitt I, Schwarz S, Wick G (1996). Immunochemical mapping of gonadotropins.. Molecular and Cellular Endocrinology, 125, 33 - 43.
    • Klonisch T, Delves PJ, Berger P, Panayotou G, Lapthorn AJ, Isaacs NW, Wick G, Lund T, Roitt IM (1996). Relative location of epitopes involved in synergistic antibody binding using human chorionic gonadotropin as a model.. European Journal of Immunology, 26, 1897 - 1905.
    • Delves PJ, Kidd VJ (1996). The genetic control of glycosylation.. In Isenberg DA, Rademacher T (Ed.), Abnormalities of IgG Glycosylation and Immunological Disorders (pp. 171 - 199). : John Wiley and Sons Ltd..
    • Roitt IM, Delves PJ, Lund T (1996). Modified human chorionic gonadotropin (beta-hCG) proteins and their medical use..
    • Delves PJ, Jeddi PA, Keusch J, Lydyard PM (1996). The effect of pregnancy on lymphocytic beta-1,4-galactosyltransferase and IgG glycosylation..

    1995

    • Roitt IM, Delves PJ (1995). Essential Immunology Review..
    • Roitt IM, Delves PJ (1995). Interactive Core Tutorials in Immunology (CD-ROM and internet)..
    • Delves PJ (1995). Essential techniques: Antibody Applications..
    • Peet N, Delves PJ, de Souza B, Cambridge G, Wilkinson L, Klonisch T, Matear P, Vyakarnam A, Lund T (1995). The immune response to HIV gp120 induced by nucleic acid immunization (NAI).. Annals of the New York Academy of Sciences, 772, 257 - 260.
    • Roitt IM, Chapel H, Haeney M, Delves PJ (1995). Immunology Series CD-ROM. Publ MedTech. Los Angeles, USA..
    • Keusch J, Lydyard PM, Isenberg DA, Delves PJ (1995). Beta-1,4-galactosyltransferase activity in B-cells detected using a simple ELISA-based assay.. Glycobiology, 5, 365 - 370.

    1994

    • Jeddi PA, Lund T, Bodman KB, Sumar N, Lydyard PM, Pouncey L, Heath LS, Kidd VJ, Delves PJ (1994). Reduced galactosyltransferase mRNA levels are associated with the agalactosyl IgG found in arthritis-prone MRL-lpr/lpr strain mice.. Immunology, 83(3), 484 - 488.
    • Jeddi PA, Lund T, Bodman KB, Sumar N, Lydyard PM, Pouncey L, Heath L, Kidd VJ, Delves PJ (1994). Reduced galactosyltransferase mRNA levels associated with agalactosyl IgG in MRL-lpr/lpr strain mice.. Immunology, 83, 484 - 488.
    • Jackson AM, Lund T, Delves PJ, Klonisch T, Peet NM, Arreguin C, Smith M, Berger P, Wick G, Roitt IM (1994). The construction of epitope-loss mutants of human chorionic gonadotropin..
    • Delves PJ, Lydyard PM (1994). Lymphocyte development.. In Delves PJ (Ed.), Cellular Immunology Labfax (pp. 33 - 43). : Bios Scientific Publishers.
    • Keusch J, Lydyard PM, Isenberg DA, Delves PJ (1994). Measurement of lymphocytic beta1,4 galactosyltransferase activities in the presence of a neoglycoprotein..
    • Keusch J, Bodman KB, Lydyard PM, Isenberg DA, Delves PJ (1994). Lymphocytic galactosyltransferase activities using an ELISA based assay..
    • Roitt IM, Delves PJ (1994). Immunology QuizBank. Computer discs/CD-ROM containing 422 interactive multiple choice questions, with 2,110 learning responses..
    • Bodman KB, Hutchings PR, Jeddi PA, Delves PJ, Rook GAW, Sumar N, Roitt IM, Lydyard PM (1994). IgG glycosylation in autoimmune-prone strains of mice.. Clinical and Experimental Immunology, 95, 103 - 107.
    • Delves PJ (1994). Immunotechnology. Gosling,J.P., Reen, D.J. Portland Press.. Biotechnology and Applied Biochemistry, 2, 14 - .
    • Delves PJ (1994). Cell surface antigens. In Delves PJ (Ed.), Cellular Immunology Labfax (pp. 115 - 153). : Bios Scientific Publishers.
    • Jeddi PA, Bodman KB, Keusch J, Lund T, Lydyard PM, Isenberg DA, Delves PJ (1994). beta1,4-galactosyltransferase gene expression in rheumatoid arthritis..
    • Jeddi PA, Lund T, Bodman KB, Lydyard PM, Isenberg DA, Delves PJ (1994). Measurement of lymphocytic galactosyltransferase mRNA levels in rheumatoid arthritis patients using an RNAse protection assay..
    • Delves PJ (1994). Principles of Cellular and Molecular Immunology. Austyn, J.M., Wood,K.J. Oxford University Press.. Immunology Today, 15, 391 - .
    • Bodman KB, Jeddi PA, Delves PJ, Lydyard PM (1994). Localization of agalactosyl IgG secreting B cells in a murine model of arthritis..
    • Delves PJE (1994). Cellular Immunology Labfax.
    • Delves PJ (1994). Components of an immune response. In Nicholson B (Ed.), Synthetic Vaccines (pp. 1 - 25). : Blackwell Scientific Publications..
    • Peet NM, Lund T, Delves PJ, De Souza JB, Ramos B, Roitt IM1994 (1994). Murine antibody response to native and mutant HIV-1 gp120..

    1993

    • Delves PJ, McLachlan SM, Drewe E, Fukuma N, Petersen VB, Rees Smith B (1993). Cross-reactive idiotypes on high affinity IgG class human monoclonal thyroglobulin autoantibodies.. Journal of Autoimmunity, 6, 77 - 91.
    • Delves PJ, Jeddi PA, Bodman KB, Sumar N, Lydyard PM, Lund T, Pouncey L, Heath L, Kidd VJ (1993). Relationship of lymphocytic galactosyltransferase mRNA levels to IgG glycosylation in autoimmune prone mice..

    1992

    • Delves PJ, Lund T, Roitt IM (1992). Process for modifying proteins..
    • Delves PJ, Roitt IM (1992). Complement, Post-C3 (lytic) pathway.. In Roitt IM, Delves PJ (Ed.), Encyclopedia of Immunology (pp. 385 - 387). : Academic Press. 1992..
    • Delves PJ, Roitt IM (1992). Interleukin-2.. In Roitt IM, Delves PJ (Ed.), Encyclopedia of Immunology (pp. 903 - 906). : Academic Press..
    • Delves PJ, Jeddi PA, Bodman K, Sumar N, Lund T, Pouncey L, Heath L, Kidd VJ (1992). Genes and IgG glycosylation in autoimmune and non-autoimmune strains of mice.. Annals of the Rheumatic Diseases, 51(1275), 1276 - .
    • Jeddi PA, Sumar N, Bodman K, Lund T, Pouncey L, Heath L, Kidd VJ, Delves PJ (1992). Galactosyltransferase-associated protein kinase gene structure and IgG glycosylation in autoimmune strains of mice..
    • Roitt IM, Delves PJE (1992). Encyclopedia of Immunology. 3 volumes..
    • Delves PJ, Roitt IM (1992). Immunoglobulin gene superfamily. In Roitt IM, Delves PJ (Ed.), Encyclopedia of Immunology (pp. 831 - 833). : Academic Press..
    • Roitt IM, Delves PJ (1992). Slide Atlas of Essential Immunology. 4 volumes, 521 slides. Blackwell Scientific Publications. Oxford, UK.
    • Delves PJ (1992). Autoimmunity.. In Roitt IM, Delves PJ (Ed.), Encyclopedia of Immunology’ (pp. 198 - 210). : Academic Press..

    1991

    • Bhalla AK, Paavonen T, Williams MM, Delves PJ, Lydyard PM (1991). Regulation of interleukin-1 and tumour necrosis factor gene expression in myelomonocytic cell lines by 1,25-dihydroxyvitamin D3.. Immunology, 72, 61 - 64.

    1990

    • Lydyard PM, Delves PJ, Colaco B1990 (1990). Restricted clonality of T-cells in rheumatoid arthritis joints.. Arthritis and Rheumatism, 33, 299 - .
    • Paavonen T, Quartey-Papafio R, Delves PJ, Mackenzie L, Lund T, Youinou P, Lydyard PM (1990). CD5 mRNA expression and auto-antibody production in early human B cells immortalized by EBV.. Scand J Immunol, 31(3), 269 - 274.
    • Lydyard PM, Delves PJ, Colaco B (1990). Restricted clonality of T cells in the joints of rheumatoid arthritis patients.. Arthritis Rheum, 33(2), 299 - .
    • Paavonen T, Quartey-Papafio R, Delves PJ, MacKenzie L, Lydyard PM (1990). CD5 mRNA expression and autoantibody production in early human B-cells.. Scandinavian Journal of Immunology, 31, 269 - 274.
    • Delves PJ, Roitt IM (1990). Mechanisms in autoimmunity - an overview.. Horizons in Medicine, 2, 66 - 75.
    • Roitt IM, Dwek RA, Parekh RB, Rademacher TW, Warren C, Alavi A, Axford JS, Bodman K, Bond A, Colaco B, Cooke A, Delves PJ, Hay FC, Isenberg DA, Lydyard PM, MacKenzie L, Rook G, Smith M, Sumar N, Tsoulfa G1990 (1990). The significance of changes in IgG carbohydrate in rheumatoid arthritis and tuberculosis.. Advances in Host Defence Mechanisms, 7, 77 - 91.
    • Delves PJ, Lund T, Axford JS, Alavi-Sadrieh A, Lydyard PM, MacKenzie L, Smith MD, Kidd V (1990). Polymorphism and expression of the galactosyltransferase-associated protein kinase gene in normal individuals and galactosylation-defective rheumatoid arthritis patients.. Arthritis and Rheumatism, 33, 1655 - 1664.

    1989

    • Delves PJ, Kidd V, Lund T, Alavi-Sadrieh A, Axford JS, Smith MD, MacKenzie L, Lydyard PM, Roitt IM (1989). The galactosyltransferase activator gene is polymorphic in both normal individuals and galactosylation-defective rheumatoid arthritis patients.. European Journal of Clinical Investigation, 19, 470 - .
    • PAAVONEN T, MACKENZIE L, DELVES PJ, LUND T, LYDYARD PM (1989). DIFFERENTIAL REGULATION OF CD5 AND CD4 MOLECULES ON HUMAN T-CELLS. SCAND J IMMUNOL, 30(5), 644 - 644.
    • Paavonen T, Broker B, Worman C, Delves PJ, Lydyard PM (1989). Regulation of CD5 expression on CLL: Differential effects of PMA and IFN alpha..

    1988

    • Axford JS, Bond A, Delves PJ, Alavi A, Kidd V, Lund T, Hay FC, Cooke A (1988). Peripheral B cell galactosyltransferase activity is reduced in the MRL arthritic mouse but there are no gross structural changes in the gene..
    • Axford JS, Delves PJ, Alavi A, Kidd V, Lund T, Lydyard PM, Isenberg DA, Roitt IM (1988). Reduced lymphocytic galactosyltransferase activity in rheumatoid arthritis is not the result of enzyme inhibition nor gross structural changes in the gene..
    • Delves PJ, Roitt IM (1988). Long term spectrotypic and idiotypic stability of thyroglobulin autoantibodies in patients with Hashimoto’s thyroiditis.. Clinical and Experimental Immunology, 71, 459 - 463.

    1987

    • Savill CM, Delves PJ, Kioussis D, Walker P, Lydyard PM, Colaco B, Shipley M, Roitt IM1987 (1987). A minority of patients with rheumatoid arthritis show a dominant rearrangement of T-cell beta chain genes in synovial lymphocytes.. Scandinavian Journal of Immunology, 25, 629 - 635.
    • Rayner DC, Delves PJ, Warren D, Roitt IM, Champion BR (1987). T-cell hybridomas specific for self and foreign thyroglobulins.. Immunology, 60, 231 - 237.

    1984

    • Roitt IM, Pujol-Borrell R, Hanafusa T, Delves PJ, Bottazzo GF, Kohn LD (1984). Asialoagalactothyroglobulin binds to the surface of human thyroid cells at a site distinct from the ‘microsomal’ autoantigen.. Clinical and Experimental Immunology, 56, 129 - 134.
    • Delves PJ, Roitt IM (1984). Idiotypic determinants on human thyroglobulin autoantibodies derived from the serum of Hashimoto patients and EB virus transformed cell lines.. Clinical and Experimental Immunology, 57, 33 - 40.
    • Tatham PE, Delves PJ (1984). Flow cytometric detection of membrane potential changes in murine lymphocytes induced by Concanavalin A.. Biochemical Journal, 221, 137 - 146.

    1983

    • Tatham PE, Delves PJ, Banga JP, Roitt IM (1983). Cell-surface changes during mitogenic stimulation of lymphocytes assessed by binding of wheat-germ agglutinin and other plant lectins.. Biochimica et Biophysica Acta (BBA) - Biomembranes, 732, 509 - 518.
    • Delves PJ (1983). Histocompatibility Antigens: Structure and Function. Parham,P., Strominger,J (eds). Chapman and Hall.. The Lancet., 341, 74 - .

    1982

    • Tatham PE, Delves PJ, Banga JP, Roitt IM (1982). Flow cytometric analysis of lectin binding to activated lymphocytes.. In (Ed.), Cytometry: Proceedings of the Combined Conference for Analytical Cytology and Cytometry and VIth International Symposium on Flow Cytometry. Schloss-Elmue, Germany (pp. 76 - 81). : Springer.

    1980

    • Tatham PE, Delves PJ, Shen L, Roitt IM (1980). Chemotactic factor-influenced membrane potential changes in rabbit neutrophils monitored by the fluorescent dye 3,3’-dipropylthiadicarbocyanine iodide.. Biochimica et Biophysica Acta (BBA) - Biomembranes, 602, 285 - 298.

    • Delves PJ (). Optimisation of antigens for use in anti-cancer vaccines.. Proceedings of the 14th Annual Symposium on Emerging Frontiers in Management of Advanced Stage Cancers, , - .
    • Delves PJ (). Biology of the immune system.. In Porter RS (Ed.), The Merck Manual: Professional edition. 19th Edn. (pp. - ). : Merck.
    • Delves PJ (). Allergic and other hypersensitivity disorders.. In (Ed.), The Merck Manual: Professional edition. (pp. - ). : Merck.
    • Delves PJ (). Allergic reactions.. In Porter RS (Ed.), The Merck Manual: Home edition (pp. - ). : Merck.
    • Delves PJ, Martin SJ, Burton DR, Roitt IM (). Essential Immunology. 12th Edn.
    • Delves P (). Biology of the immune system.. In (Ed.), The Merck Manual: Home edition. 3rd Edn. (pp. - ). : Merck.