Prof Benny Chain

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Personal Profile

Name: Benny Chain Email: b.chain@ucl.ac.uk
Title: Prof Tel: 0203108 2129
Department: Div of Infection & Immunity Fax:
Position: Professor of Immunology Address: Cruciform Building, Gower St., London, WC1E6BT
Research Domain: Ageing, Basic Life Sciences, Cancer, Data Science, Global Health, Infection, Immunology & Inflammation, Personalised Medicine Web Page: Personal Web Page

Profile

Research Description

I have worked for many years on the biology of the antigen presenting cell, especially on the mechanisms of antigen processing in dendritic cells. In the last few years I have become interested in developing mathematical, statistical and computational tools which will help us to integrate and make sense of the huge amounts of data generated by the functional genomics revolution. My research group is now concentrating on using high throughput sequencing to study the regulation of T and B cell receptor repertoire diversity.  We focus on the immune response to major pathogens including HIV and Mycobacterium tuberculosis. The research’s major  aim is to understand the fundamental rules which regulate the host-pathogen interface . But the research questions are shaped by an awareness of current clinical priorities and challenges, articulated through our close links with UCL Hospitals, the Institute for Immunity and Transplantation and the Bloomsbury Centre for Pathogen Research.


Research Activities

Antigen processing and presentation

Computational Immunology and Bioinformatics

Innate Immunity

T cell receptor repertoire

Education Description

Organiser and lecturer on IMIN3004 Cellular Pathology

Lecturer on IMIN 3002 Immunology  in Health and Disease and CEL3140 Interdisciplinary Cell Biology


UCL Collaborators

Dr Mahdad Noursadeghi; Prof David Katz; Prof Greg Towers

External Collaborators

Publications

    2014

    • Kundu R, Chain BM, Coussens AK, Khoo B, Noursadeghi M (2014). Regulation of CYP27B1 and CYP24A1 hydroxylases limits cell-autonomous activation of vitamin D in dendritic cells.. Eur J Immunol, , - . doi:10.1002/eji.201344157
    • Zhang C, Zhou S, Chain BM (2014). Hybrid spreading of the Internet worm Conficker. , , - .
    • Madi A, Shifrut E, Reich-Zeliger S, Gal H, Best K, Ndifon W, Chain B, Cohen IR, Friedman N (2014). T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity.. Genome Res, , - . doi:10.1101/gr.170753.113
    • Thomas N, Best K, Cinelli M, Reich-Zeliger S, Gal H, Shifrut E, Madi A, Friedman N, Shawe-Taylor J, Chain B (2014). Tracking global changes induced in the CD4 T cell receptor repertoire by immunization with a complex antigen using short stretches of CDR3 protein sequence.. Bioinformatics, , - . doi:10.1093/bioinformatics/btu523
    • Zhang C, Zhou S, Cox IJ, Chain BM (2014). Optimizing Hybrid Spreading in Metapopulations. , , - .

    2013

    • Thomas N, Heather J, Ndifon W, Shawe-Taylor J, Chain B (2013). Decombinator: a tool for fast, efficient gene assignment in T-cell receptor sequences using a finite state machine.. Bioinformatics, 29(5), 542 - 550. doi:10.1093/bioinformatics/btt004
    • Thomas N, Heather J, Pollara G, Simpson N, Matjeka T, Noursadeghi M, Chain B, Shawe-Taylor J (2013). The immune system as a biomonitor: Explorations in innate and adaptive immunity. Interface Focus, 3(2), - . doi:10.1098/rsfs.2012.0099
    • Tomlinson GS, Bell LC, Walker NF, Tsang J, Brown JS, Breen R, Lipman M, Katz DR, Miller RF, Chain BM, Elkington PT, Noursadeghi M (2013). HIV-1 infection of macrophages dysregulates innate immune responses to Mycobacterium tuberculosis by inhibition of interleukin 10.. J Infect Dis, , - . doi:10.1093/infdis/jit621
    • Waysbort N, Russ D, Chain BM, Friedman N (2013). Coupled IL-2-Dependent Extracellular Feedbacks Govern Two Distinct Consecutive Phases of CD4 T Cell Activation.. J Immunol, , - . doi:10.4049/jimmunol.1301575
    • Dhanoya A, Wang T, Keshavarz-Moore E, Fassati A, Chain BM (2013). Importin-7 mediates nuclear trafficking of DNA in mammalian cells.. Traffic, 14(2), 165 - 175. doi:10.1111/tra.12021
    • Tomlinson GS, Hardavella G, Brown J, Succony L, Navani N, Thomas N, Chain BM, Janes SM, Noursadeghi M (2013). DIFFERENTIATION OF TUBERCULOSIS AND SARCOIDOSIS BY TRANSCRIPTIONAL PROFILING OF IMMUNE RESPONSES IN MEDIASTINAL LYMPH NODE SAMPLES. doi:10.1136/thoraxjnl-2013-204457.43

    2012

    • Tomlinson GS, Booth H, Petit SJ, Potton E, Towers GJ, Miller RF, Chain BM, Noursadesghi M (2012). Adherent human alveolar macrophages exhibit a transient pro-inflammatory profile that confounds responses to innate immune stimulation. PLoS One, 7, - .
    • Matjeka T, Summerfield V, Noursadeghi M, Chain BM (2012). Chemical toxicity to keratinocytes triggers dendritic cell activation via an IL-1α path.. J Allergy Clin Immunol, 129(1), 247-50.e1-3 - . doi:10.1016/j.jaci.2011.08.018
    • Hardwick N, Ledermann JA, Aitkens E, Chain B (2012). Pre-clinical assessment of autologous DC-based therapy in ovarian cancer patients with progressive disease.. Cancer Immunol Immunother, 61(11), 1929 - 1939. doi:10.1007/s00262-012-1252-2
    • Thomas N, Matejovicova L, Srikusalanukul W, Shawe-Taylor J, Chain B (2012). Directional Migration of Recirculating Lymphocytes through Lymph Nodes via Random Walks. PLoS ONE, 7(9), - . doi:10.1371/journal.pone.0045262
    • Dhanoya A, Chain BM, Keshavarz-Moore E (2012). Role of DNA topology in uptake of polyplex molecules by dendritic cells.. Vaccine, 30(9), 1675 - 1681. doi:10.1016/j.vaccine.2011.12.102
    • Prokopowicz Z, Marcinkiewicz J, Katz DR, Chain BM (2012). Neutrophil myeloperoxidase: soldier and statesman.. Arch Immunol Ther Exp (Warsz), 60(1), 43 - 54. doi:10.1007/s00005-011-0156-8

    2011

    • Tulone C, Sponaas AM, Raiber EA, Tabor AB, Langhorne J, Chain BM (2011). Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1.. PLoS One, 6(10), e24886 - . doi:10.1371/journal.pone.0024886
    • Dhanoya A, Chain BM, Keshavarz-Moore E (2011). The impact of DNA topology on polyplex uptake and transfection efficiency in mammalian cells.. J Biotechnol, 155(4), 377 - 386. doi:10.1016/j.jbiotec.2011.07.023
    • Evans R, Coussens AK, Kriston-Vizi J, Chain BJ, Noursadeghi M (2011). The effect of vitamin D on monocyte biology: a physiological perspective.
    • Alpizar YA, Chain B, Collins MK, Greenwood J, Katz D, Stauss HJ, Mitchison NA (2011). Ten years of progress in vaccination against cancer: the need to counteract cancer evasion by dual targeting in future therapies.. Cancer Immunol Immunother, 60(8), 1127 - 1135. doi:10.1007/s00262-011-0985-7
    • Hardwick N, Chain B (2011). Epitope spreading contributes to effective immunotherapy in metastatic melanoma patients.. Immunotherapy, 3(6), 731 - 733. doi:10.2217/imt.11.62
    • Tomlinson GS, Cashmore TJ, Elkington PT, Yates J, Lehloenya RJ, Tsang J, Brown M, Miller RF, Dheda K, Katz DR, Chain BM, Noursadeghi M (2011). Transcriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test.. Eur J Immunol, 41(11), 3253 - 3260. doi:10.1002/eji.201141841
    • Le Bert N, Chain BM, Rook G, Noursadeghi M (2011). DC priming by M. vaccae inhibits Th2 responses in contrast to specific TLR2 priming and is associated with selective activation of the CREB pathway.. PLoS One, 6(4), e18346 - . doi:10.1371/journal.pone.0018346
    • Bewley MA, Marriott HM, Tulone C, Francis SE, Mitchell TJ, Read RC, Chain B, Kroemer G, Whyte MK, Dockrell DH (2011). A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.. PLoS Pathog, 7(1), e1001262 - . doi:10.1371/journal.ppat.1001262
    • Bewley MA, Pham TK, Marriott HM, Noirel J, Chu HP, Ow SY, Ryazanov AG, Read RC, Whyte MK, Chain B, Wright PC, Dockrell DH (2011). Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae.. Mol Cell Proteomics, 10(6), M111.008193 - . doi:10.1074/mcp.M111.008193
    • Tomlinson GS, Elkington PTG, Bell L, Walker NF, Tsang J, Brown J, Breen R, Lipman M, Katz DR, Miller RF, Chain BM, Noursadeghi M (2011). HIV-1 INFECTION OF MACROPHAGES DYSREGULATES PRO-INFLAMMATORY HOST RESPONSES TO MYCOBACTERIUM TUBERCULOSIS THROUGH INHIBITION OF INTERLEUKIN 10. doi:10.1136/thoraxjnl-2011-201054b.130

    2010

    • Impens F, Colaert N, Helsens K, Ghesquière B, Timmerman E, De Bock PJ, Chain BM, Vandekerckhove J, Gevaert K (2010). A quantitative proteomics design for systematic identification of protease cleavage events.. Mol Cell Proteomics, 9(10), 2327 - 2333. doi:10.1074/mcp.M110.001271
    • Kim JY, Lee YG, Kim MY, Byeon SE, Rhee MH, Park J, Katz DR, Chain BM, Cho JY (2010). Src-mediated regulation of inflammatory responses by actin polymerization.. Biochem Pharmacol, 79(3), 431 - 443. doi:10.1016/j.bcp.2009.09.016
    • Prokopowicz ZM, Arce F, Biedroń R, Chiang CL, Ciszek M, Katz DR, Nowakowska M, Zapotoczny S, Marcinkiewicz J, Chain BM (2010). Hypochlorous acid: a natural adjuvant that facilitates antigen processing, cross-priming, and the induction of adaptive immunity.. J Immunol, 184(2), 824 - 835. doi:10.4049/jimmunol.0902606
    • Dhanoya A, Chain B, Keshavarz-Moore E (2010). Characterisation of plasmid DNA complexes for application in genetic immunization.
    • Tomlinson GS, Elkington PTG, Miller RF, Chain BM, Brown J, Noursadeghi M (2010). Macrophage inflammatory responses in pulmonary infection.
    • Raiber EA, Tulone C, Zhang Y, Martinez-Pomares L, Steed E, Sponaas AM, Langhorne J, Noursadeghi M, Chain BM, Tabor AB (2010). Targeted delivery of antigen processing inhibitors to antigen presenting cells via mannose receptors.. ACS Chem Biol, 5(5), 461 - 476. doi:10.1021/cb100008p
    • Cho JY, Katz DR, Skubitz KM, Chain BM (2010). Conventional protein kinase C plays a critical role in negative regulation of CD98-induced homotypic aggregation.. Tissue Antigens, 75(1), 19 - 29. doi:10.1111/j.1399-0039.2009.01389.x
    • Chain B, Bowen H, Hammond J, Posch W, Rasaiyaah J, Tsang J, Noursadeghi M (2010). Error, reproducibility and sensitivity: a pipeline for data processing of Agilent oligonucleotide expression arrays.. BMC Bioinformatics, 11, 344 - . doi:10.1186/1471-2105-11-344

    2009

    • Raiber EA, Tulone C, Steed E, Chain BM, Tabor AB (2009). Optical imaging of the role of Cathepsin E in antigen processing.
    • Lee YG, Chain BM, Cho JY (2009). Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappaB alpha via activation of the phosphoinositide-3-kinase and Akt pathways.. Int J Biochem Cell Biol, 41(4), 811 - 821. doi:10.1016/j.biocel.2008.08.011
    • Mazzon M, Jones M, Davidson AD, Chain B, Jacobs M (2009). Dengue Virus NS5 Inhibits Interferon-α signalling by Blocking STAT2 phosphorylation. The Journal of Infectious Diseases, 200(8), 1261 - 1270.
    • Rasaiyaah J, Noursadeghi M, Kellam PACBM (2009). Transcriptional and functional defects of dendritic cells derived from the MUTZ-3 leukaemia line.. Immunology, , - .
    • Mazzon M, Jones M, Davidson A, Chain B, Jacobs M (2009). Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation.. J Infect Dis, 200(8), 1261 - 1270. doi:10.1086/605847
    • Noursadeghi M, Tsang J, Miller RF, Straschewski S, Kellam P, Chain BM, Katz DR (2009). Genome wide innate immune responses in HIV 1 infected macrophages are preserved despite attenuation of the NF-κappa B activation pathway.. The Journal of Immunology, 182(1), 319 - 328.
    • Tsang J, Chain BM, Miller RF, Webb BL, Barclay W, Towers GJ, Katz DR, Noursadeghi M (2009). HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation. AIDS, 23(17), 2255 - 2263. doi:10.1097/QAD.0b013e328331a4ce
    • Arce F, Rowe HM, Chain B, Lopes L, Collins MK (2009). Lentiviral vectors transduce proliferating dendritic cell precursors leading to persistent antigen presentation and immunization.. Mol Ther, 17(9), 1643 - 1650. doi:10.1038/mt.2009.149
    • Playfair JHL, Chain BM (2009). Immunology at a Glance.

    2008

    • Reske A, Pollara G, Krummenacher C, Katz DR, Chain BM (2008). Glycoprotein-dependent and TLR2-independent innate immune recognition of herpes simplex virus-1 by dendritic cells. The Journal of Immunology, 180(11), 7525 - 7536.
    • Noursadeghi M, Tsang J, Haustein T, Miller RF, Chain BM, Katz DR (2008). Quantitative imaging assay for NF-kappaB nuclear translocation in primary human macrophages. Journal of Immunological Methods, 329((1-2)), 194 - 200.
    • Tsang J, Chain B, Miller R, Katz D, Noursadeghi M (2008). HIV-1 INFECTION CAN INFECT AND REPLICATE IN HUMAN MACROPHAGES UNDETECTED BY THE HOST INNATE IMMUNE SYSTEM. J INFECTION, 57(5), 430 - 430.
    • Mazzon M, Jones M, Strang A, Davidson A, Chain B, Jacobs M (2008). DENGUE VIRUS NS5 INHIBITS IFNA SIGNALLING AND TOGETHER WITH NS4B REDUCES CELLULAR STAT2 LEVELS. J INFECTION, 57(5), 431 - 432.
    • Chiang CL, Ledermann JA, Aitkens E, Benjamin E, Katz DR, Chain BM (2008). Oxidation of ovarian epithelial cancer cells by hypochlorous acid enhances immunogenicity and stimulates T cells that recognise autologous primary tumour. Clinical Cancer Research, 14(15), 4898 - 4907.
    • Noursadeghi M, Tsang J, Haustein T, Miller RF, Chain BM, Katz DR (2008). Quantitative imaging assay for NF-kappaB nuclear translocation in primary human macrophages.. Journal of Immunological Methods, 329(1), 194 - 200.
    • Chain B, M N, M G, M T, J W, E (2008). HIV blocking antibodies following immunisation with chimaeric peptides coding a short N-terminal sequence of the CCR5 receptor.. Vaccine, , - . doi:10.1016/j.vaccine.2008.08.025
    • Arce F, Rowe H, Lopes L, Escors D, Chain B, Collins MK (2008). Sustained antigen presentation after lentiviral immunization.

    2007

    • Rasaiyaah J, Yong K, Katz DR, Kellam P, Chain BM (2007). Dendritic cells and myeloid leukaemias: plasticity and commitment in cell differentiation. British Journal of Haematology, 138(3), 281 - 290.
    • Prokopowicz Z, Chain BM, Katz DR (2007). Dendritic cell antigen processing of chlorinated protein antigens.
    • Noursadeghi M, Tsang J, Haustein T, Miller RF, Chain BM, Katz DR (2007). Quantitative imaging assay for NF-kappaB nuclear translocation in primary human macrophages. Journal of Immunological Methods, 329, 194 - 200.
    • Handley ME, Rasaiyaah J, Chain BM, Katz DR (2007). Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?. International Journal of Experimental Pathology, 86, 111 - 126.
    • Tulone C, Tsang J, Prokopowicz Z, Grosvenor N, Chain B (2007). Natural cathepsin E deficiency in the immune system of C57BL/6J mice.. Immunogenetics, 59(12), 927 - 935. doi:10.1007/s00251-007-0256-0
    • Handley ME, Rasaiyaah J, Barnett J, Thakker M, Pollara G, Katz DR, Chain BM (2007). Expression and function of mixed lineage kinases in dendritic cells. International Immunology, 19(8), 923 - 933.
    • Reske A, Pollara G, Krummenacher C, Chain BM, Katz DR (2007). Understanding HSV-1 entry glycoproteins. Reviews in Medical Virology, 17(3), 205 - 215.
    • Tulone C, Uchiyama Y, Novelli M, Grosvenor N, Saftig P, Chain BM (2007). Haematopoietic development and immunological function in the absence of cathepsin D.. BMC Immunol, 8, 22 - . doi:10.1186/1471-2172-8-22
    • Tulone C, Tsang J, Prokopowicz Z, Grosvenor N, Chain BM (2007). Natural cathepsin E deficiency in the immune system of C57BL/6 mice. Immunogenetics, 59(12), 927 - 935.

    2006

    • Kanan JH, Chain BM (2006). Modulation of dendritic cell differentiation and cytokine secretion by the hydatid cyst fluid of Echinococcus granulosus.. Immunology, 118(2), 271 - 278. doi:10.1111/j.1365-2567.2006.02375.x
    • Pollara G, Handley ME, Kwan A, Chain BM, Katz DR (2006). Autocrine type I interferon amplifies dendritic cell responses to lipopolysaccharide via the nuclear factor-kappaB/p38 pathways.. Scand J Immunol, 63(3), 151 - 154. doi:10.1111/j.1365-3083.2006.01727.x
    • Rowe HM, Lopes L, Ikeda Y, Bailey R, Barde I, Zenke M, Chain BM, Collins MK (2006). Immunization with a lentiviral vector stimulates both CD4 and CD8 T cell responses to an ovalbumin transgene.. Mol Ther, 13(2), 310 - 319. doi:10.1016/j.ymthe.2005.08.025
    • Free P, Hurley CA, Kageyanna T, Chain BM, Tabor AB (2006). Mannose–pepstatin conjugates as targeted inhibitors of antigen processing. Organic and Biomolecular Chemistry, 4, 1817 - 1830. doi:10.1039/b600060f
    • Swetman Andersen CA, Handley M, Pollara G, Ridley AJ, Katz DR, Chain BM (2006). beta1-integrins determine the dendritic morphology which enhances DC-SIGN-mediated particle capture by dendritic cells. International Immunology, 18, 1295 - 1303.
    • Newton PJ, Weller IV, Williams IG, Miller RF, Copas A, Tedder RS, Katz DR, Chain BM (2006). Monocyte derived dendritic cells from HIV-1 infected individuals partially reconstitute CD4 T-cell responses. AIDS, 20(2), 171 - 180.
    • Chiang CL, Ledermann JA, Rad AN, Katz DR, Chain BM (2006). Hypochlorous acid enhances immunogenicity and uptake of allogeneic ovarian tumor cells by dendritic cells to cross-prime tumor-specific T cells. Cancer Immunology, Immunotherapy, 55(11), 1384 - 1395.

    2005

    • Handley ME, Thakker M, Pollara G, Chain BM, Katz DR (2005). JNK activation limits dendritic cell maturation in response to reactive oxygen species by the induction of apoptosis. FREE RADICAL BIO MED, 38(12), 1637 - 1652. doi:10.1016/j.freeabbiomed.2005.02.022
    • Pollara G, Kwan A, Newton P, Handley ME, Chain BM, Katz DR (2005). Dendritic cells in viral pathogenesis: protective or defective?. International Journal of Experimental Pathology, 86, 187 - 204.
    • Al-Shangiti AM, Nair SP, Chain BM (2005). The interaction between staphylococcal superantigen-like proteins and human dendritic cells. Clinical and Experimental Immunology, 140(3), 461 - 469.
    • Handley ME, Thakker M, Pollara G, Chain BM, Katz DR (2005). JNK activation limits dendritic cell maturation in response to reactive oxygen species by the induction of apoptosis. Free Radical Biology and Medicine, 38, 1637 - 1652.
    • Chain BM, Myers R (2005). Variability and conservation in hepatitis B virus core protein.. BMC Microbiol, 5, 33 - . doi:10.1186/1471-2180-5-33
    • Rew SB, Peggs K, Sanjuan I, Pizzey AR, Koishihara Y, Kawai S, Kosaka M, Ozaki S, Chain B, Yong KL (2005). Generation of potent antitumor CTL from patients with multiple myeloma directed against HM1.24.. Clinical Cancer Research, 11, 3377 - 3384. doi:10.1158/1078-0432.CCR-04-0650
    • Pollara G, Katz DR, Chain BM (2005). Lighting up dendritic cell activation: immune regulation and viral exploitation. Journal of Cell Physiology, 205, 161 - 162.
    • Chain BM, Free P, Medd P, Swetman C, Tabor AB, Terrazzini N (2005). The Expression and Function of Cathepsin E in Dendritic Cells. The Journal of Immunology, 174, 1791 - 1800.
    • Pachiadakis I, Pollara G, Chain BM, Naoumov NV (2005). Is hepatitis C virus infection of dendritic cells a mechanism facilitating viral persistence?. The Lancet Infectious Diseases, 5(5), 296 - 304.
    • Handley ME, Pollara G, Chain BM, Katz DR (2005). The use of targeted microbeads for quantitative analysis of the phagocytic properties of human monocyte-derived dendritic cells. Journal of Immunological Methods, 297, 27 - 38.

    2004

    • Pollara G, Jones M, Handley ME, Rajpopat M, Kwan A, Coffin RS, Foster G, Chain BM, Katz DR (2004). Herpes simplex virus type-1-induced activation of myeloid dendritic cells: the roles of virus cell interaction and paracrine type 1 IFN secretion. The Journal of Immunology, 173(6), 4108 - 4119.
    • Pollara G, Katz DR, Chain BM (2004). The host response to herpes simplex virus infection. Current Opinion in Infectious Diseases, 17(3), 199 - 203.
    • Al-Shangiti AM, Naylor CE, Nair SP, Briggs DC, Henderson B, Chain BM (2004). Structural relationships and cellular tropism of staphylococcal superantigen-like proteins. Infection and Immunity, 72(7), 4261 - 4270.
    • Pollara G, Jones M, Handley ME, Rajpopat M, Kwan A, Coffin RS, Foster G, Chain B, Katz DR (2004). Herpes simplex virus type-1-induced activation of myeloid dendritic cells: the roles of virus cell interaction and paracrine type I IFN secretion.. J Immunol, 173(6), 4108 - 4119.
    • Cho JY, Kim AR, Joo HG, Kim BH, Rhee MH, Yoo ES, Katz DR, Chain BM (2004). Cynaropicrin, a sesquiterpene lactone, as a new strong regulator of CD29 and CD98 functions. Biochemical and Biophysical Research Communications, 313(4), 954 - 961.
    • Marcinkiewicz J, Biedroń R, Maresz K, Kwaśny-Krochin B, Bobek M, Kontny E, Maśliński W, Chain B (2004). Oxidative modification of type II collagen differentially affects its arthritogenic and tolerogenic capacity in experimental arthritis.. Arch Immunol Ther Exp (Warsz), 52(4), 284 - 291.
    • MacCormac LP, Jacque JM, Chain BM (2004). The functional consequences of delivery of HIV-1 Nef to dendritic cells using an adenoviral vector. Vaccine, 22(3-4), 528 - 535.

    2003

    • Cho JY, Katz DR, Chain BM (2003). Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation. British Journal of Pharmacology, 140, 269 - 276.
    • Rad AN, Pollara G, Sohaib SM, Chiang C, Chain BM, Katz DR (2003). The differential influence of allogeneic tumour cell death via DNA damage on dendritic cell maturation and antigen presentation. Cancer Research, 63(16), 5143 - 5150.
    • Cho JY, Chain BM, Vives J, Horesji V, Katz DR (2003). Regulation of CD43-induced U937 homotypic aggregation. Experimental Cell Research, 290(1), 155 - 167. doi:10.1016/s0014-4827(03)00322-7
    • Creusot RJ, Thomsen LL, Tite JP, Chain BM (2003). Local cooperation dominates over competition between CD4+ T cells of different antigen / MHC specificity. The Journal of Immunology, 171(1), 240 - 246.
    • Creusot RJ, Biswas JS, Thomsen LL, Tite JP, Mitchison NA, Chain BM (2003). Instructions of naive CD4+ T cells by polarised CD4+ T cells within dendritic cell clusters. European Journal of Immunology, 33(6), 1686 - 1696. doi:10.1002/eji.200323811
    • Samady L, Costigliola E, MacCormac L, McGrath Y, Cleverly S, Lilley CE, Smith J, Latchman DS, Chain BM, Coffin RS (2003). Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs-HSV vectors for dendritic cell-mediated immunotherapy. Journal of Virology, 77(6), 3768 - 3776. doi:10.1128/JVI.77.6.3768-3776.2003
    • Bunyard P, Handley M, Pollara G, Rutault K, Wood I, Chaudry M, Alderman C, Foreman J, Katz DR, Chain BM (2003). Ribotoxic stress activates p38 and JNK kinases and modulates the antigen presenting activity of dendritic cells. Molecular Immunology, 39(13), 815 - 827.
    • Chain BM, Marcinkiewicz J (2003). The dendritic cell in bacterial infection: sentinel or Trojan horse?. In Henderson B, Oyston PCF (Ed.), Bacterial evasion of host immune responses (pp. 3 - 20). : Cambridge University Press.
    • Cho JY, Skubitz KM, Katz DR, Chain BM (2003). CD98-dependent homotypic aggregation is associated with translocation of protein kinase Cë, and activation of mitogen activated protein kinases. Experimental Cell Research, 286(1), 1 - 11.
    • Newton PJ, Weller IVD, Katz DR, Chain BM (2003). Autologous apoptopic T cells interact with dendritic cells but do not affect their surface phenotype or their ability to induce recall immune responses. Clinical and Experimental Immunology, 133(1), 50 - 58.
    • Petrovska L, Lopes L, Simmons CP, Pizza M, Dougan G, Chain BM (2003). Modulation of dendritic cell endocytosis and antigen processing pathways by Escherichia coli heat-labile enterotoxin and mutant derivatives. Vaccine, 21, 1445 - 1454.
    • Pollara G, Speidel K, Samady L, Rajpopat M, McGrath Y, Ledermann J, Coffin RS, Katz DR, Chain B (2003). Herpes simplex virus infection of dendritic cells: Balance among activation, inhibition, and immunity. The Journal of Infectious Diseases, 187(2), 165 - 178.
    • Rew SB, Lopes L, Koishihara Y, Kosaka M, Ozaki S, Peggs K, Chain B, Yong KL (2003). Potent anti-tumour cytotoxic T lymphocytes directed against the myeloma antigen HMI.24..
    • Chain BM (2003). Current issues in antigen presentation - focus on the dendritic cell. Immunology Letters, 89, 237 - 241.

    2002

    • Brodeur I, Boyhan A, Heinrichs N, Plumpton C, Chain BM, Rowan WC (2002). LCPTP-MAP kinase interaction: permanent partners or transient associates?. Molecular Immunology, 39(7-8), 475 - 483.
    • Swetman CA, Leverrier Y, Garg R, Gan CH, Ridley AJ, Katz DR, Chain BM (2002). Extension, retraction and contraction in the formation of a dendritic cell dendrite: distinct roles for Rho GTPases. European Journal of Immunology, 32(7), 2074 - 2083.
    • Kvirkvelia N, Vojnovic I, Warner TD, Athie-Morales V, Free P, Rayment N, Chain BM, Rademacher T, Lund T, Roitt IM, Delves PJ (2002). Placentally-derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells. Clinical and Experimental Immunology, 127(2), 263 - 269.
    • Rew SB, Lopes L, Peggs K, Koishihara Y, Kosaka M, Ozaki S, Chain B, Yong KL (2002). Generation of T-cell mediated immune responses to the myeloma antigen, HM1.24..
    • Alderman CJJ, Shah S, Foreman JC, Chain BM, Katz DR (2002). The role of advanced oxidation protein products in regulation of dendritic cell function. Free Radical Biology and Medicine, 32(5), 377 - 385.
    • Kwasny-Krochin B, Bobek M, Kontny E, Gluszko P, Biedron R, Chain BM, Maslinski W, Marcinkiewicz J (2002). Effect of taurine chloramine, the product of activated neutrophils, on the development of collagen-induced arthritis in DBA 1/J mice. Amino Acids, 23(4), 419 - 426.
    • MacDougall TH, Shattock RJ, Madsen C, Chain BM, Katz DR (2002). Regulation of primary HIV-1 isolate replication in dendritic cells. Clinical and Experimental Immunology, 127(1), 66 - 71.
    • Alderman CJJ, Bunyard PR, Chain BM, Foreman JC, Leake DS, Katz DR (2002). Effects of oxidised low density lipoprotein on dendritic cells: a possible immunoregulatory component of the atherogenic micro-environment?. Cardiovascular Research, 55, 806 - 819. doi:10.1016/S0008-6363(02)00447-9

    2001

    • Cho JY, Fox DA, Horejsi V, Sagawa K, Skubitz KM, Katz DR, Chain B (2001). The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation. Blood, 98(2), 374 - 382.
    • Dixon GL, Newton PJ, Chain BM, Katz D, Andersen SR, Wong S, van der Ley P, Klein N, Callard RE (2001). Dendritic cell activation and cytokine production induced by group B Neisseria meningitidis: interleukin-12 production depends on lipopolysaccharide expression in intact bacteria. Infection and Immunity, 69(7), 4351 - 4357. doi:10.1128/IAI.69.7.4351-4357.2001
    • Simmons CP, Ghaem-Magami M, Petrovska L, Lopes L, Chain BM, Williams NA, Dougan G (2001). Immunomodulation using bacterial enterotoxins. Scandinavian Journal of Immunology, 53(3), 218 - 226.
    • Strid J, Lopes L, Marcinkiewicz J, Petrovska L, Nowak B, Chain BM, Lund T (2001). A defect in bone marrow derived dendritic cell maturation in the non-obese diabetic mouse. Clinical and Experimental Immunology, 123(3), 375 - 381.
    • McGrath Y, Burton S, Samady L, MacCormack L, Lilley CE, Robinson M, Chain B, Reay P, Coffin RS (2001). Herpes simplex virus vectors allowing high efficiency gene transfer to dendritic cells with dendritic cell activation: development of vectors for the immunotherapy of cancer and infectious disease. CANCER GENE THER, 8, S15 - S15.
    • (2001). Dendritic cell activation and cytokine production induced by group B Neisseria meningitis: IL-12 production requires lipopolysaccharide to be expressed in intact bacteria. Infection and Immunity, 69, 4351 - 4357.
    • Kvirkvelia N, Vojnovic I, Warner TD, Athie-Morales V, Free P, Rayment N, Chain BM, Rademacher TW, Lund T, Roitt IM, Delves PJ (2001). Low molecular weight heat stable immunosuppressive material from placenta inhibits IL-2-dependent proliferation of CTLL-2 cells via the EP4 receptor..
    • McGrath Y, Burton S, Samady L, Maccormack L, Lilley C, Robinson M, Chain B, Coffin R (2001). Herpes simplex virus vectors allowing high efficiency gene transfer to dendritic cells with dendritic cell activation: Development of vectors for the immunotherapy of cancer and infectious disease.. CLINICAL CANCER RESEARCH, 7(11), 3757S - 3757S.
    • Free P, Tabor AB, Chain B (2001). Targetting MHCII antigen processing: Mannose conjugates of a cathepsin E aspartic protease inhibitor..
    • Creusot RJ, Thomsen LL, van Wely CA, Topley P, Tite JP, Chain BM (2001). Early commitment of adoptively transferred CD4+ T cells following particle-mediated DNA vaccination: implications for the study of immunomodulation. Vaccine, 19(13-14), 1678 - 1687.

    2000

    • Lopes LM, Maroof A, Dougan G, Chain BM (2000). Inhibition of T-cell response by Escherichia coli heat-labile enterotoxin-treated epithelial cells. Infection and Immunity, 68(12), 6891 - 6895.
    • Woodhead VE, Stonehouse TJ, Binks MH, Speidel K, Fox DA, Gaya A, Hardie D, Henniker AJ, Horejsi V, Sagawa K, Skubitz KM, Taskov H, Todd RF, III VA, A K, D R C, B M (2000). Novel molecular mechanisms of dendritic cell-induced T cell activation. International Immunology, 12(7), 1051 - 1061.
    • Marcinkiewicz J, Chain B, Nowak B, Grabowska A, Bryniarski K, Baran J (2000). Antimicrobial and cytotoxic activity of hypochlorous acid: interactions with taurine and nitrite. Inflammation Research, 49(6), 280 - 289.
    • Mitchison NA, Katz DR, Chain B (2000). Self/nonself discrimination among immunoregulatory (CD4) T cells. Seminars in Immunology, 12(3), 179 - 183.
    • Drakesmith H, Chain B, Beverley P (2000). How can dendritic cells cause autoimmune disease?. Immunology Today, 21(5), 214 - 217.
    • Bryniarski K, Biedron R, Petrovska L, Free P, Chain BM, Marcinkiewicz J (2000). Phagocytosis of Bacteria by mouse bone-marrow derived dendritic cells affects their ability to process a heterologous soluble antigen in vitro. Central European Journal of Immunology, , 210 - 216.
    • Medd PG, Chain BM (2000). Protein degradation in MHC class II antigen presentation: opportunities for immunomodulation. Seminars in Cell and Developmental Biology, 11(3), 203 - 210.

    1999

    • Tatla S, Woodhead V, Foreman JC, Chain BM (1999). The role of reactive oxygen species in triggering proliferation and IL-2 secretion in T cells. Free Radical Biology and Medicine, 26, 14 - 24.
    • Lopes LM, Hughson E, Anstee Q, O'Neill DA, Katz DR, Chain BM (1999). Vectorial function of major histocompatibility complex class II in a human intestinal cell line. Immunology, 98, 16 - 26.
    • Rutault K, Alderman C, Chain BM, Katz DR (1999). Reactive oxygen species activate human peripheral blood dendritic cells. Free Radical Biology and Medicine, 26, 232 - 238.
    • Marcinkiewicz J, Nowak B, Grabowska A, Bobek M, Petrovska L, Chain B (1999). Regulation of murine dendritic cell functions in vitro by taurine chloramine, a major product of the neutrophil myeloperoxidase-halide system.. Immunology, 98(3), 371 - 378.
    • Stonehouse TJ, Woodhead VE, Herridge PS, Ashrafian H, George M, Chain BM, Katz DR (1999). Molecular characterization of U937-dependent T-cell co-stimulation.. Immunology, 96(1), 35 - 47.
    • Speidel K, Samady L, Ledermann JA, Chain BM, Coffin R, Katz D (1999). Development of transfected dendritic cells for immunotherapy of ovarian cancer. BRIT J CANCER, 80, 21 - 21.
    • Mota F, Rayment N, Chong S, Singer A, Chain B (1999). The antigen-presenting environment in normal and human papillomavirus (HPV)-related premalignant cervical epithelium. Clinical and Experimental Immunology, 116(1), 33 - 40.
    • Mota F, Calder V, Rutault K, Singer A, Chain B (1999). Characterization of soluble factors from cultures of premalignant cervical epithelium. European Journal of Gynaecological Oncology, 20, 262 - 267.
    • O'Neil D, Swanton C, Jones A, Medd PG, Rayment N, Chain B (1999). IFN-gamma down-regulates MHC expression and antigen processing in a human B cell line.. J Immunol, 162(2), 791 - 798.

    1998

    • Orrell RW, Jurkat-Rott K, Lehmann-Horn F, Lane RJ (1998). Familial cramp due to potassium-aggravated myotonia.. Journal of Neurology, Neurosurgery and Psychiatry, 65(4), 569 - 572.
    • Woodhead V, Binks MH, Chain BM, Katz DR (1998). From sentinel to messenger: an extended phenotypic analysis of the monocyte to dendritic cell transition. Immunology, 96, 552 - 559.
    • Wimasundera SS, Katz DR, Chain BM (1998). Responses to human rhinovirus in CD45 T cells subsets isolated from tonsil. European Journal of Immunology, 28, 4374 - 4381.
    • Drakesmith H, O'Neil D, Schneider SC, Binks M, Medd P, Sercarz E, Beverley P, Chain B (1998). In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen.. Proc Natl Acad Sci U S A, 95(25), 14903 - 14908.
    • Coffin RS, Thomas SK, Thomas NSB, Lilley CE, Pizzey AR, Griffiths CH, Gibb BJ, Wagstaff MJ, Inges SJ, Binks MH, Chain BM, Thrasher AJ, Rutault K, Latchman DS (1998). Pure populations of transduced primary human cells can be produced using GFP expressing herpes virus vectors and flow cytometry. Gene Therapy, 5(5), 718 - 722.
    • Mota FF, Rayment NB, Kanan JH, Singer A, Chain BM (1998). Differential regulation of JLA-DQ expression by keratinocytes and Langerhans' cells in normal premalignant cervical epithelium. Tissue Antigens, 52, 286 - 293.
    • Tatla S, Woodhead V, Foreman JC, Chain BM (1998). Cellular redox state rather than reactive oxygen species regulate proliferation and IL-2 secretion during Tcell activation. Free Radical Biology and Medicine, 26, 14 - 24.
    • Mota FF, Rayment NB, Kanan JH, Singer A, Chain BM (1998). Differential regulation of HLA-DQ expression by keratinocytes and Langerhans' cells in normal and premalignant cervical epithelium. Tissue Antigens, 52, 286 - 293.
    • Drakesmith H, O'Neil D, Schneider S, Binks MH, Medd P, Sercaz E, Beverley P, Chain BM (1998). Direct priming of T cells against cryptic determinants by dendritic cells exposed to interleukin-6 and native antigen. Proceedings of the National Academy of Sciences of the United States of America, 95, 14903 - 14908.
    • Marcinkiewicz J, Grabowska A, Chain BM (1998). Modulation of antigen-specific T cell activation in vitro by taurine chloramine. Immunology, 94, 325 - 330.
    • Coffin RS, Thomas SK, Thomas NSB, Lilley CE, Pizzey AR, Griffiths CH, Gibb BJ, Wagstaff MJD, Inges SJ, Binks MH, Chain BM, Thrasher AJ, Rutault K, Latchman DS (1998). Populations of transduced primary human cells can be produced using GFP expressing herpes virus vectors and flow cytometry. Gene Therapy, 5, 718 - 722.

    1997

    • Wimaslasundera S, Katz DR, Chain BM (1997). Characterisation of the T cell response to human rhinovirus in children: implications for understanding the pathology of the common cold. The Journal of Infectious Diseases, 176, 755 - 759.
    • Marcinkiewicz J, Grabowska A, Bryniarski K, Chain BM (1997). Enhancement of CD4+ T cell dependent IL-2 production in vitro by murine alvelolar macrophages: the role of leukotrine B4. Immunology, 91, 369 - 374.
    • Mota F, Kanan J, Rayment N, Mould T, Singer A, Chain B (1997). Cathepsin E expression by normal and premalignant cervical epithelium. American Journal of Pathology, 150(4), 1223 - 1229.
    • Nayeem N, Barker PJ, Binns RM, Kanan JHC, Chain BM (1997). Isolation and N-terminal sequence determination of a novel æë T cell surface antigen. Molecular Immunology, 34, 583 - 591.
    • Kanan JHC, Nayeem N, Binns RM, Chain BM (1997). Novel mechanisms for variability in a member of the scavenger-receptor cysteine-rich superfamily. Immunogenetics, 46, 276 - 282.

    1996

    • Sealy L, Mota F, Rayment N, Tatnell P, Kay J, Chain B (1996). Regulation of cathepsin E expression during human B cell differentiation in vitro.. Eur J Immunol, 26(8), 1838 - 1843. doi:10.1002/eji.1830260826
    • Woodhead VE, Binks MH, Katz DR, Chain BM (1996). Flow cytometric and functional studies on human dendritic cells using the adhesion monoclonal antibody panel. TISSUE ANTIGENS, 48(4-II), AS512 - AS512.
    • Stonehouse TJ, Chain BM, Katz DR (1996). Role of non-lineage molecules in co-stimulation. TISSUE ANTIGENS, 48(4-II), NL506 - NL506.
    • Binks M, Hughson E, Hewison M, Faulkner L, Chain BM, Katz DR (1996). Extracellular matrix modulation of homotypic and heterotypic leukocyte clustering. J LEUKOCYTE BIOL, , 177 - 177.
    • Marcinkiewicz J, Grabowska A, Chain B (1996). Is there a role for nitric oxide in regulation of T cell secretion of IL-2'?. JOURNAL OF LEUKOCYTE BIOLOGY, , 79 - 79.
    • Stonehouse TJ, Herridge PS, Chain BM, Katz DR (1996). Role of novel adhesion molecules as co-stimulatory molecules. TISSUE ANTIGENS, 48(4-II), AS507 - AS507.
    • Woodhead VE, Binks MH, Katz DR, Chain BM (1996). Flow cytometric and functional studies on human dendritic cells using the myeloid monoclonal antibody panel. TISSUE ANTIGENS, 48(4-II), MC604 - MC604.
    • Woodhead VE, Binks MH, Katz DR, Chain BM (1996). Flow cytometric studies on human dendritic cells using the non-lineage monoclonal antibody panel. TISSUE ANTIGENS, 48(4-II), NL509 - NL509.
    • Marcinkiewicz J, Grabowska A, Chain BM (1996). Is there a role for nitric oxide in regulation of T cell secretion of IL-2?. J Immunol, 156(12), 4617 - 4621.

    1995

    • CHAIN BM, HUGHSON E (1995). ANTIGEN-PROCESSING PATHWAY IN CACO-2 CELLS. J CELL BIOCHEM, , 244 - 244.
    • BINKS MH, KATZ DR, CHAIN BM (1995). EXTRACELLULAR-MATRIX AND THE MATURATION OF HUMAN PERIPHERAL-BLOOD DENDRITIC CELLS. J CELL BIOCHEM, , 9 - 9.
    • Ibrahim MA, Chain BM, Katz DR (1995). The injured cell: the role of the dendritic cell system as a sentinel receptor pathway.. Immunol Today, 16(4), 181 - 186.
    • BINKS MH, CHAIN BM, KATZ DR (1995). THE EXPRESSION OF CD95 (FAS) IS INDUCED ON HUMAN PERIPHERAL-BLOOD DERIVED DENDRITIC CELLS BY EXPOSURE TO FIBRONECTIN. ARTHRITIS RHEUM, 38(9), 11 - 11.
    • Gao L, Walter J, Travers P, Stauss H, Chain BM (1995). Tumor-associated E6 protein of human papillomavirus type 16 contains an unusual H-2Kb-restricted cytotoxic T cell epitope.. J Immunol, 155(12), 5519 - 5526.
    • Marcinkiewicz J, Grabowska A, Chain B (1995). Nitric oxide up-regulates the release of inflammatory mediators by mouse macrophages.. Eur J Immunol, 25(4), 947 - 951. doi:10.1002/eji.1830250414
    • CHAIN BM, GAO LQ, TRAVERS P, STAUSS H (1995). CTL EPITOPES WITHIN THE HUMAN PAPILLOMA-VIRUS E6 PROTEIN. J CELL BIOCHEM, , 289 - 289.

    1994

    • Ibrahim MA, Chain BM, Katz DR (1994). The role of non-adhesive T-cell-accessory cell interactions in the induction of T-cell proliferative hyporesponsiveness.. Immunology, 81(4), 521 - 531.
    • BEVERLEY PCL, SADOVNIKOVA E, ZHU X, HICKLING J, GAO L, CHAIN B, COLLINS S, CRAWFORD L, VOUSDEN K, STAUSS HJ (1994). STRATEGIES FOR STUDYING MOUSE AND HUMAN IMMUNE-RESPONSES TO HUMAN PAPILLOMAVIRUS TYPE-16.
    • Gao L, Chain B, Sinclair C, Crawford L, Zhou J, Morris J, Zhu X, Stauss H (1994). Immune response to human papillomavirus type 16 E6 gene in a live vaccinia vector.. J Gen Virol, 75 ( Pt 1), 157 - 164.
    • Vint IA, Foreman JC, Chain BM (1994). The gold anti-rheumatic drug auranofin governs T cell activation by enhancing oxygen free radical production.. Eur J Immunol, 24(9), 1961 - 1965. doi:10.1002/eji.1830240904

    1993

    • Vint IA, Chain BM, Foreman JC (1993). The interaction of auranofin and buthionine sulfoximine blocks activation of human peripheral T lymphocytes.. Cell Immunol, 152(1), 152 - 161. doi:10.1006/cimm.1993.1275
    • Vint IA, Chain BM, Foreman JC (1993). The effects of auranofin on activation and interleukin-2 release from human peripheral blood mononuclear cells.. Agents Actions, 40(3-4), 209 - 214.
    • Poirier G, Chain B (1993). Analysis of the cellular requirements for the binding of exogenous peptides to MHC class II molecules.. Cell Immunol, 152(2), 456 - 467. doi:10.1006/cimm.1993.1304
    • Poirier G, Faulkner L, Chain B (1993). Isolation and characterization of a new murine MHC class II transcription mutant cell line.. Mol Immunol, 30(16), 1433 - 1441.
    • Olsen I, Adams G, Watson G, Chain B, Abraham D (1993). Multi-level regulation of lysosomal gene expression in lymphocytes. Biochemical and Biophysical Research Communications, 195(1), 327 - 335.
    • Olsen I, Bou-Gharios G, Abraham D, Chain B (1993). Lysosomal enzyme transfer from different types of lymphoid cell. Experimental Cell Research, 209(1), 133 - 139.
    • Ellis J, Ibrahim MA, Chain BM, Katz DR (1993). The role of dendritic cells in the regulation of T cell cytokine synthesis.. Adv Exp Med Biol, 329, 99 - 104.
    • Dabrowski M, Ibrahim MA, Chain BM, Katz DR (1993). The role of dendritic cells as co-stimulators in tolerance induction.. Adv Exp Med Biol, 329, 105 - 110.
    • Levine TP, Chain BM (1993). Endocytic activity of dendritic cells is similar to other antigen presenting cells.. Adv Exp Med Biol, 329, 11 - 15.
    • Marcinkiewicz J, Chain BM (1993). Regulation of in vitro release of TH2 type cytokines (IL-4, IL-6) in the T cell response to the trinitrophenyl (TNP) hapten.. Cell Immunol, 146(2), 406 - 411. doi:10.1006/cimm.1993.1036
    • Hastings GZ, Francis MJ, Rowlands DJ, Chain BM (1993). Antigen processing and presentation of human rhinovirus to CD4 T cells is facilitated by binding to cellular receptors for virus.. Eur J Immunol, 23(6), 1340 - 1345. doi:10.1002/eji.1830230623
    • Marcinkiewicz J, Chain BM (1993). Differential cytokine regulation by eicosanoids in T cells primed by contact sensitisation with TNP.. Cell Immunol, 149(2), 303 - 314. doi:10.1006/cimm.1993.1157
    • Coleman N, Greenfield IM, Hare J, Kruger-Gray H, Chain BM, Stanley MA (1993). Characterization and functional analysis of the expression of intercellular adhesion molecule-1 in human papillomavirus-related disease of cervical keratinocytes.. Am J Pathol, 143(2), 355 - 367.
    • Marcinkiewicz J, Chain BM (1993). Differential regulation of cytokine production by nitric oxide.. Immunology, 80(1), 146 - 150.
    • Hastings GZ, Francis MJ, Rowlands DJ, Chain BM (1993). Epitope analysis of the T cell response to a complex antigen: proliferative responses to human rhinovirus capsids.. Eur J Immunol, 23(9), 2300 - 2305. doi:10.1002/eji.1830230937

    1992

    • Ibrahim MA, Ellis JS, Chain BM, Katz DR (1992). Sensitization of allo-specific T lymphocytes in vivo: role of antigen-presenting cells.. Immunobiology, 186(5), 362 - 377.
    • CHAIN BM, LEYSHONSORLAND K, SIVAJOTHY MT (1992). HEMOCYTE HETEROGENEITY IN THE COCKROACH PERIPLANETA-AMERICANA ANALYZED USING MONOCLONAL-ANTIBODIES. J CELL SCI, 103, 1261 - &.
    • Marcinkiewicz J, Radziszewski W, Chain BM (1992). Prostaglandin E2 (PGE2) differentially regulates the production of IL-2 and IL-3 by murine immune T-cells.. Folia Histochem Cytobiol, 30(1), 1 - 4.
    • Bennett K, Levine T, Ellis JS, Peanasky RJ, Samloff IM, Kay J, Chain BM (1992). Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E.. Eur J Immunol, 22(6), 1519 - 1524. doi:10.1002/eji.1830220626
    • Stauss HJ, Davies H, Sadovnikova E, Chain B, Horowitz N, Sinclair C (1992). Induction of cytotoxic T lymphocytes with peptides in vitro: identification of candidate T-cell epitopes in human papilloma virus.. Proc Natl Acad Sci U S A, 89(17), 7871 - 7875.
    • Ellis JS, Chain BM, Cooke A, Ibrahim MA, Katz DR (1992). Adjuvant composition determines the induction of type II collagen-induced arthritis.. Scand J Immunol, 36(1), 49 - 56.
    • Lopes LM, Chain BM (1992). Liposome-mediated delivery stimulates a class I-restricted cytotoxic T cell response to soluble antigen.. Eur J Immunol, 22(1), 287 - 290. doi:10.1002/eji.1830220143
    • HASTINGS GZ, CHAIN BM, CAMPBELL RO, ROWLANDS DJ, FRANCIS MJ (1992). IDENTIFICATION OF T-CELL EPITOPES FROM HUMAN RHINOVIRUS FOR USE IN SYNTHETIC PEPTIDE VACCINES.
    • Levine TP, Chain BM (1992). Endocytosis by antigen presenting cells: dendritic cells are as endocytically active as other antigen presenting cells.. Proc Natl Acad Sci U S A, 89(17), 8342 - 8346.

    1991

    • Kuperberg G, Ellis J, Marcinkiewicz J, Chain BM (1991). Temperature-induced stress abrogates co-stimulatory function in antigen-presenting cells.. Eur J Immunol, 21(11), 2791 - 2795. doi:10.1002/eji.1830211121
    • Davies DH, McIndoe GA, Chain BM (1991). Cancer of the cervix: prospects for immunological control.. Int J Exp Pathol, 72(2), 239 - 251.
    • Yin L, Chain BM (1991). Suppression of lymphokine production in anti-minor histocompatibility antigen responses.. Cytokine, 3(1), 5 - 11.
    • Chain B (1991). Penicillin and beyond.. Nature, 353(6344), 492 - 494. doi:10.1038/353492a0
    • Ibrahim MA, Coode WK, Takei F, Ellis JS, Chain BM, Katz DR (1991). Chemically modified antigen-presenting cells induce T lymphocyte allospecific hyporesponsiveness.. J Immunol, 147(12), 4086 - 4093.
    • Ellis J, Chain BM, Davies DH, Ibrahim MA, Katz DR, Kaye PM, Lightstone E (1991). Antigen presentation by dendritic cells provides optimal stimulation for the production of interleukin (IL) 2, IL 4 and interferon-gamma by allogeneic T cells.. Eur J Immunol, 21(11), 2803 - 2809. doi:10.1002/eji.1830211123
    • Marcinkiewicz J, Chain BM, Olszowska E, Olszowski S, Zgliczyński JM (1991). Enhancement of immunogenic properties of ovalbumin as a result of its chlorination.. Int J Biochem, 23(12), 1393 - 1395.
    • IBRAHIM MA, CHAIN BM, KATZ DR (1991). SENSITIZATION OF ALLOGENEIC T-CELLS INVIVO - DONOR OR HOST ANTIGEN-PRESENTING CELL-FUNCTION.
    • Levine TP, Chain BM (1991). The cell biology of antigen processing.. Crit Rev Biochem Mol Biol, 26(5-6), 439 - 473. doi:10.3109/10409239109086790

    1990

    • Davies DH, Hill CM, Rothbard JB, Chain BM (1990). Definition of murine T helper cell determinants in the major capsid protein of human papillomavirus type 16.. J Gen Virol, 71 ( Pt 11), 2691 - 2698.
    • Marcinkiewicz J, Chain BM (1990). Further studies on the regulation of lymphokine biosynthesis in contact sensitivity.. Cytokine, 2(5), 344 - 352.

    1989

    • Oben JA, Wallace GR, Chain BM, Foreman JC (1989). The stimulation of IL-2 production by anti-rheumatic drugs.. Immunology, 67(3), 328 - 332.
    • Shaw MA, Chain BM (1989). A cell-free model system for the study of antigen processing.. Int Immunol, 1(6), 619 - 623.
    • Marcinkiewicz J, Chain B (1989). Antigen-specific inhibition of IL-2 and IL-3 production in contact sensitivity to TNP.. Immunology, 68(2), 185 - 189.
    • Chain BM, Mitchison NA, Mitchison TJ, Davies DH, Marcinkiewicz J (1989). Antigen processing: current issues, exceptional cases (Thy 1 alloantigen, MHC class-II-restricted cytolytic T cells), and implications for vaccine development.. J Autoimmun, 2 Suppl, 45 - 53.
    • Flory M, Wallace GR, Oettel K, Chain BM (1989). The T-cell response to haptenated insulins. II. The antibody response.. Immunology, 66(1), 45 - 48.
    • Wallace GR, Briffa J, McCafferty I, Askenase PW, Chain BM (1989). The T-cell response to haptenated insulins. I. The proliferative response.. Immunology, 66(1), 39 - 44.
    • Chain BM, Bou-Gharios G, Olsen I (1989). Endopeptidase activities associated with the plasma membrane compartment of an antigen-presenting B cell.. Clin Exp Immunol, 75(1), 87 - 92.

    1988

    • Wallace GR, McLeod A, Chain BM (1988). Chromatographic analysis of the trinitrophenyl derivatives of insulin.. J Chromatogr, 427(2), 239 - 246.
    • OBEN JA, WALLACE G, CHAIN BM, FOREMAN JC (1988). INVOLVEMENT OF GLUTATHIONE IN THE STIMULATION OF MITOGEN-INDUCED INTERLEUKIN-2 PRODUCTION BY ANTI-RHEUMATIC DRUGS. BRIT J PHARMACOL, 95, P534 - P534.
    • Chain BM, Kaye PM, Shaw MA (1988). The biochemistry and cell biology of antigen processing.. Immunol Rev, 106, 33 - 58.

    1987

    • Chain BM (1987). Does the T-cell receptor bind to the MHC?. Nature, 329(6141), 677 - 678. doi:10.1038/329677b0
    • Howes EA, Chain BM, Smith PJ, Treherne JE (1987). Blood cells contribute to glial repair in an insect.. Tissue Cell, 19(6), 877 - 880.
    • Chain B, McCafferty I, Wallace G, Askenase PW (1987). Improvement of the in vitro T cell proliferation assay by a modified method that separates the antigen recognition and IL-2-dependent steps.. J Immunol Methods, 99(2), 221 - 228.

    1986

    • Perkins KA, Chain BM (1986). Presentation by peritoneal macrophages: modulation by antibody-antigen complexes.. Immunology, 58(1), 15 - 21.
    • CHAIN BM, LONDEI M, FELDMANN M (1986). BIOCHEMICAL AND CELLULAR QUESTIONS IN ANTIGEN PROCESSING. ANN INST PASTEUR IMM, D137(2), 320 - 323.
    • Chain BM, Kay PM, Feldmann M (1986). The cellular pathway of antigen presentation: biochemical and functional analysis of antigen processing in dendritic cells and macrophages.. Immunology, 58(2), 271 - 276.

    1985

    • Kaye PM, Chain BM, Feldmann M (1985). Nonphagocytic dendritic cells are effective accessory cells for anti-mycobacterial responses in vitro.. J Immunol, 134(3), 1930 - 1934.

    1984

    • KAYE PM, CHAIN BM, FELDMANN M (1984). ACCESSORY CELL HETEROGENEITY IN ANTI-MYCOBACTERIAL RESPONSES. IMMUNOBIOLOGY, 167(1-3), 155 - 156.

    1983

    • CHAIN BM, ANDERSON RS (1983). INFLAMMATION IN INSECTS - THE RELEASE OF A PLASMATOCYTE DEPLETION FACTOR FOLLOWING INTERACTION BETWEEN BACTERIA AND HEMOCYTES. J INSECT PHYSIOL, 29(1), 1 - 4.
    • CHAIN BM, ANDERSON RS (1983). ANTI-BACTERIAL ACTIVITY OF THE CELOMIC FLUID FROM THE POLYCHAETE, GLYCERA-DIBRANCHIATA .2. PARTIAL-PURIFICATION AND BIOCHEMICAL-CHARACTERIZATION OF THE ACTIVE FACTOR. BIOL BULL, 164(1), 41 - 49.
    • CHAIN BM, ANDERSON RS (1983). A BACTERICIDAL AND CYTO-TOXIC FACTOR IN THE CELOMIC FLUID OF THE POLYCHAETE, GLYCERA-DIBRANCHIATA. DEV COMP IMMUNOL, 7(4), 625 - 628.
    • CHAIN BM, ANDERSON RS (1983). ANTI-BACTERIAL ACTIVITY OF THE CELOMIC FLUID OF THE POLYCHAETE, GLYCERA-DIBRANCHIATA .1. THE KINETICS OF THE BACTERICIDAL REACTION. BIOL BULL, 164(1), 28 - 40.
    • Chain BM, Anderson RS (1983). Observations on the cytochemistry of the hemocytes of an insect, Galleria mellonella.. J Histochem Cytochem, 31(5), 601 - 607.

    1982

    • ANDERSON RS, CHAIN BM (1982). ANTI-BACTERIAL ACTIVITY IN THE CELOMIC FLUID OF A MARINE ANNELID, GLYCERA-DIBRANCHIATA. J INVERTEBR PATHOL, 40(3), 320 - 326.
    • CHAIN BM, ANDERSON RS (1982). SELECTIVE DEPLETION OF THE PLASMATOCYTES IN GALLERIA-MELLONELLA FOLLOWING INJECTION OF BACTERIA. J INSECT PHYSIOL, 28(4), 377 - 384.

    1981

    • CHAIN BM, BONE Q, ANDERSON PAV (1981). ELECTROPHYSIOLOGY OF A MYOID EPITHELIUM IN CHELOPHYES (COELENTERATA, SIPHONOPHORA). J COMP PHYSIOL, 143(3), 329 - 338.
    • CHAIN BM (1981). A SODIUM-DEPENDENT TWITCH MUSCLE IN A COELENTERATE - THE ECTODERMAL MYOEPITHELIUM OF THE GASTROZOOIDS IN AGALMA-SP (SIPHONOPHORA). J EXP BIOL, 90(FEB), 101 - 108.
    • CHAIN BM, ANDERSON RS (1981). RAPID PLASMATOCYTE DEPLETION IN AN INSECT FOLLOWING EXPERIMENTAL-INFECTION. AM ZOOL, 21(4), 981 - 981.

    1980

    • CHAIN BM (1980). ELECTROGENESIS IN THE EURYHALINE OSMOCONFORMER CORDYLOPHORA-LACUSTRIS (HYDROZOA). J EXP BIOL, 88(OCT), 175 - 193.
    • CHAIN BM (1980). THE TRANS-EPITHELIAL POTENTIAL AND OSMOTIC REGULATION IN THE GREEN HYDRA. J EXP BIOL, 88(OCT), 161 - 173.

    • Evans , Coussens , Kriston-Vizi J, Chain , Noursadeghi (). The effect of vitamin D on monocyte biology: a physiological perspective.