Dr Helen Baxendale

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Personal Profile

Name: Helen Baxendale Email: helen.baxendale@ucl.ac.uk
Title: Dr Tel: 0044 207 905 2370
Department: Research Department of Infection Fax: 0044 207 813 8494
Position: Honorary Senior Research Associate Address: Hans Stauss? Unit, Division of Infection and Immunity, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF
Research Domain: Infection, Immunology & Inflammation, Personalised Medicine Web Page:  

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Research Description

A translation research programme to explore and characterise the development of functional humoral immunity through childhood in health and disease, with a focus on characterising immune responses to pneumococcal bacteria and pneumococcal vaccines.

Research Activities

Characterising B cell development through childhood in health and disease

Characterising the immune response to infection and immunisation in healthy populations of different ages and in patients with primary and secondary immunodeficiency

Molecular immunology

Education Description

UCL Collaborators

Dr Kenth Gustafsson

External Collaborators

Publications

    2009

    • Smith CM, Lo PC, Scuderi A, Kolberg J, Baxendale H, Goldblatt D, Oggioni MR, Felici F, Andrew PW (2009). Peptide mimics of two pneumococcal capsular polysaccharide serotypes (6B and 9V) protect mice from a lethal challenge with Streptococcus pneumoniae. Eur.J.Immunol., 39(6), 1527 - 1535.

    2008

    • Jacobsen MC, Thiebaut R, Fisher C, Sefe D, Clapson M, Klein N, Baxendale H (2008). Pediatric Human Immunodeficiency Virus Infection and Circulating IgD(+) Memory B Cells. The Journal of Infectious Diseases, 198(4), 481 - 485.
    • Yuste J, Sen A, Truedsson L, Jonsson G, Tay LS, Hyams C, Baxendale HE, Goldblatt F, Botto M, Brown JS (2008). Impaired opsonisation with C3b and phagocytosis of Streptococcus pneumoniae in serum from subjects with defects in the classical complement pathway. Infection and Immunity, 76(8), 3761 - 3770.
    • Baxendale H, Johnson M, Stephens RCM, Yuste J, Klein N, Brown JS, Goldblatt D (2008). Natural human antibodies to pneumococcus have distinctive molecular characteristics and protect against pneumococcal disease. Clinical and Experimental Immunology, 151(1), 51 - 60.
    • Lanemo Myhrinder A, Hellqvist E, Sidorova E, Soderberg A, Baxendale H, Dahle C, Willander K, Tobin G, Backman E, Soderberg O, Rosenquist R, Horkko S, Rosen A (2008). A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood, 111(7), 3838 - 3848.

    2007

    • Laurie KL, Blundell MP, Baxendale HE, Howe SJ, Sinclair J, Qasim W, Brunsberg U, Thrasher AJ, Holmdahl R, Gustafsson K (2007). Cell-specific and efficient expression in mouse and human B cells by a novel hybrid immunoglobulin promoter in a lentiviral vector. Gene Therapy, 14(23), 1623 - 1631. doi:10.1038/sj.gt.3303021

    2006

    • Baxendale HE, Goldblatt D (2006). Correlation of molecular characteristics, isotype, and in vitro functional activity of human antipneumococcal monoclonal antibodies. Infection and Immunity, 74(2), 1025 - 1031.

    2005

    • Stephens R, Rashid M, Dixon G, Baxendale H, Mythen M (2005). Do levels of antibody to endotoxin core change with time?. Shock, 23, 189 - .

    2000

    • Baxendale H, Davis Z, White HN, Spellerberg M, Stevenson FK, Goldblatt D (2000). Immunogenetic analysis of the immune response to pneumococcal polysaccharides. European Journal of Immunology, 30(4), 1214 - 1223.