Dr Astrid Wingler


Personal Profile

Name: Astrid Wingler Email: a.wingler@ucl.ac.uk
Title: Dr Tel: 020 7679 2681
Department: Genetics, Evolution & Environment Fax: 020 7679 7096
Position: Senior Lecturer Address: Darwin Building, University College London, Gower Street, London, WC1E 6BT
Research Domain: Basic Life Sciences Web Page: Personal Web Page


Research Description

Our research focuses on the role of sugar signalling in plant development and in the perception of environmental signals. For example, my group exploits natural genetic variation to investigate the genetic basis and molecular mechanisms that regulate leaf senescence. Most of this research is conducted with the model species Arabidopsis, but we also use a perennial relative of Arabidopsis, Arabis alpina, to explore how senescence is regulated by environmental conditions in perennial plants. In addition, I am interested in the pathways that determine plant growth in response to temperature.

Research Activities

Plant Biology

Education Description

I teach a variety of topics in Plant Biology, such as plant physiology and metabolism, environmental biology, plant ecology, genetic engineering, genomic and functional genomic techniques. In addition to my contributions to traditional lecture-based undergraduate courses, my teaching includes the organisation of a field course and lectures to schools and the public.

UCL Collaborators

External Collaborators



    • Wingler A (2015). Comparison of signaling interactions determining annual and perennial plant growth in response to low temperature. FRONTIERS IN PLANT SCIENCE, 5, - . doi:10.3389/fpls.2014.00794
    • Wingler A, Juvany M, Cuthbert C, Munné-Bosch S (2015). Adaptation to altitude affects the senescence response to chilling in the perennial plant Arabis alpina.. J Exp Bot, 66(1), 355 - 367. doi:10.1093/jxb/eru426


    • Nunes C, Schluepmann H, Delatte TL, Wingler A, Silva AB, Feveiro PS, Jansen M, Wiese-Klinkenberg A, Wiese-Klinkenberg A, Paul M (2013). Regulation of growth by the trehalose pathway: Relationship to temperature and sucrose. Plant Signaling & Behavior, 8(12), e26626 - e26626. doi:10.4161/psb.26626
    • O'Hara LE, Paul MJ, Wingler A (2013). How do sugars regulate plant growth and development? New insight into the role of trehalose-6-phosphate.. Mol Plant, 6(2), 261 - 274. doi:10.1093/mp/sss120
    • Wingler A, Paul MJ (2013). The role of trehalose metabolism in photosynthetic development and leaf senescence. In Biswal B, Krupinska K, Biswal UC (Ed.), Plastid Development in Leaves During Growth and Senescence (pp. - ). : Springer.
    • Nunes C, O'Hara LE, Primavesi LF, Delatte TL, Schluepmann H, Somsen GW, Silva AB, Fevereiro PS, Wingler A, Paul MJ (2013). The Trehalose 6-Phosphate/SnRK1 Signaling Pathway Primes Growth Recovery following Relief of Sink Limitation. PLANT PHYSIOLOGY, 162(3), 1720 - 1732. doi:10.1104/pp.113.220657


    • Byrne EH, Prosser I, Muttucumaru N, Curtis TY, Wingler A, Powers S, Halford NG (2012). Overexpression of GCN2-type protein kinase in wheat has profound effects on free amino acid concentration and gene expression.. Plant Biotechnol J, 10(3), 328 - 340. doi:10.1111/j.1467-7652.2011.00665.x
    • Wingler A, Stangberg EJ, Saxena T, Mistry R (2012). Interactions between temperature and sugars in the regulation of leaf senescence in the perennial herb Arabis alpina L.. J Integr Plant Biol, 54(8), 595 - 605. doi:10.1111/j.1744-7909.2012.01145.x
    • Wingler A, Paul MJ (2012). Regulation of resource allocation and growth - Preface. Journal of Experimental Botany, 63(9), 3321 - 3323. doi:10.1093/jxb/ers087
    • Wingler A, Delatte TL, O'Hara LE, Primavesi LF, Jhurreea D, Paul MJ, Schluepmann H (2012). Trehalose 6-phosphate is required for the onset of leaf senescence associated with high carbon availability.. Plant Physiol, 158(3), 1241 - 1251. doi:10.1104/pp.111.191908


    • Wingler A (2011). Interactions between flowering and senescence regulation and the influence of low temperature in Arabidopsis and crop plants. ANN APPL BIOL, 159(3), 320 - 338. doi:10.1111/j.1744-7348.2011.00497.x


    • Paul M, Jhurreea D, Zhang Y, Primavesi L, Delatte T, Schluepmann H, Wingler A (2010). Up-regulation of biosynthetic processes associated with growth by trehalose 6-phosphate. Plant Signaling and Behaviour, 5(4), 1 - 7.
    • Taylor L, Nunes-Nesi A, Parsley K, Leiss A, Leach G, Coates S, Wingler A, Fernie AR, Hibberd JM (2010). Cytosolic pyruvate,orthophosphate dikinase functions in nitrogen remobilisation during leaf senescence and limits individual seed growth and nitrogen content. Plant Journal, 62, 641 - 652. doi:10.1111/j.1365-313X.2010.04179.x
    • Wingler A, Purdy SJ, Edwards SA, Chardon F, Masclaux-Daubresse C (2010). QTL analysis for sugar-regulated leaf senescence supports flowering-dependent and independent senescence pathways.. New Phytologist, 185(2), 420 - 433.


    • Wingler A, Masclaux-Daubresse C, Fischer AM (2009). Sugars, senescence, and ageing in plants and heterotrophic organisms. Journal of Experimental Botany, 60(60), 1063 - 1066. doi:10.1093/jxb/erp067
    • Zhang Y, Primavesi LF, Jhurreea D, Andralojc PJ, Mitchell RAC, Powers SJ, Schluepmann H, Delatte T, Wingler A, Paul MJ (2009). Inhibition of Snf1-related protein kinase (SnRK1) activity and regulation of metabolic pathways by trehalose 6-phosphate.. Plant Physiology, 149(4), 1860 - 1871.


    • Wingler A, Roitsch T (2008). Metabolic regulation of leaf senescence: interactions of sugar signalling with biotic and abiotic stress responses. Plant Biology, 10(S1), 50 - 62.
    • Byrne E, Wingler A, Muttucumaru N, Halford N (2008). The wheat GCN2 signalling pathway: Does this kinase play an important role in stress signalling?. doi:10.1016/j.cbpa.2008.04.410


    • Wingler A (2007). Transcriptional or post-transcriptional regulation – how does a plant know when to senesce?. New Phytologist, 175(1), 7 - 9. doi:10.1111/j.1469-8137.2007.02106.x
    • Masclaux-Daubresse C, Purdy S, Lemaitre T, Pourtau N, Taconnat L, Renou J-P, Wingler A (2007). Genetic variation suggests interaction between cold acclimation and metabolic regulation of leaf senescence. Plant Physiology, 143(1), 434 - 446. doi:10.1104/pp.106.091355


    • Pourtau N, Jennings R, Pelzer E, Pallas J, Wingler A (2006). Effect of sugar-induced senescence on gene expression and implications for the regulation of senescence in Arabidopsis. Planta, 224(3), 556 - 568. doi:10.1007/s00425-006-0243-y
    • Wingler A, Purdy S, MacLean JA, Pourtau N (2006). The role of sugars in integrating environmental signals during the regulation of leaf senescence. Journal of Experimental Botany, 57(2), 391 - 399. doi:10.1093/jxb/eri279


    • Levey S, Wingler A (2005). Natural variation in the regulation of leaf senescence and relation to other traits in Arabidopsis. Plant, Cell and Environment, 28(2), 223 - 231. doi:10.1111/j.1365-3040.2004.01266.x
    • Diaz C, Purdy S, Christ A, Morot-Gaudry JF, Wingler A, Masclaux-Daubresse C (2005). Characterization of Markers to Determine the Extent and Variability of Leaf Senescence in Arabidopsis. A Metabolic Profiling Approach.. Plant Physiology, 138(2), 898 - 908. doi:10.1104/pp.105.060764
    • Wingler A, Brownhill E, Pourtau N (2005). Mechanisms of the light-dependent induction of cell death in tobacco plants with delayed senescence. Journal of Experimental Botany, 56(421), 2897 - 2905. doi:10.1093/jxb/eri284


    • Wingler A, Mares M, Pourtau N (2004). Spatial patterns and metabolic regulation of photosynthetic parameters during leaf senescence. NEW PHYTOL, 161(3), 781 - 789. doi:10.1111/j.1469-8137.2003.00996.x
    • Wingler A, Mares M, Pourtau N (2004). Spatial patterns and metabolic regulation of photosynthetic parameters during leaf senescence.. New Phytologist, 161(3), 781 - 789. doi:10.1111/j.1469-8137.2004.00996.x
    • Pourtau N, Mares M, Purdy S, Quentin N, Ruel A, Wingler A (2004). Interactions of abscisic acid and sugar signalling in the regulation of leaf senescence.. Planta, 219(5), 765 - 772. doi:10.1007/s00425-004-1279-5
    • Kasinathan V, Wingler A (2004). Effect of reduced arginine decarboxylase activity on salt tolerance and on polyamine formation during salt stress in Arabidopsis thaliana.. Physiologia Plantarum, 121(1), 101 - 107. doi:10.1111/j.0031-9317.2004.00309.x


    • Wingler A (2002). The function of trehalose biosynthesis in plants. Phytochemistry, (5), 437 - 550.
    • Brodmann D, Schuller A, Ludwig-Muller J, Aeschbacher RA, Wiemken A, Boller T, Wingler A (2002). Induction of trehalase in Arabadopsis plants infected with the trehalase-producing pathogen Plasmodiophora brassicae. Molecular Plant-Microbe Interactions, 15(7), 693 - 700.


    • Muller J, Aeschbacher RA, Wingler A, Boller T, Wiemken A (2001). Trehalose and trehalase in Arabidopsis. Plant Physiology, 125(2), 1086 - 1093.
    • Vogel G, Fiehn O, Jean-Richard-dit-Bressel L, Boller T, Wiemken A, Aeschbacher RA, Wingler A (2001). Trehalose metabolism in Arabidopsis: Occurrence of trehalose and molecular cloning and characterisation of trehalose-6-phosphate synthase homologues. Journal of Experimental Botany, 52(362), 1817 - 1826.
    • Fritzius T, Aeschbacher RA, Wiemken A, Wingler A (2001). Induction of ApL3 expression by trehalose complements the starch-deficient Arabidopsis mutant adg2-1 lacking ApL1, the large subunit of ADP-glucose pyrophosphorylase. Plant Physiology, 126(2), 883 - 889. doi:10.1104/pp.126.2.883


    • Wingler A, Lea PJ, Quick WP, Leegood RC (2000). Photorespiration - metabolic pathways and their role in stress protection. Philosophical Transactions of the Royal Society B: Biological Sciences, 355, 1517 - 1529.
    • Wingler A, Fritzius T, Wiemken A, Boller T, Aeschbacher RA (2000). Trehalose induces the ADP-glucose pyrophosphorylase gene, ApL3, and starch synthesis in Arabidopsis. Plant Physiology, 124, 105 - 114.
    • Chen ZH, Walker RP, Acheson RM, T'csi LI, Wingler A, Lea PJ, Leegood RC (2000). Are isocitrate lyase and phosphoenolpyruvate carboxykinase involved in gluconeogenesis during senescence of barley leaves and cucumber cotyledons?. Plant and Cell Physiology, 41, 960 - 967.


    • Bungard RA, Wingler A, Morton JD, Andrews M, Press MC, Scholes JD (1999). Ammonium can stimulate nitrate and nitrite reductase in the absence of nitrate in Clematis vitalba. Plant, Cell and Environment, 22(7), 859 - 866. doi:10.1046/j.1365-3040.1999.00456.x
    • Wingler A, Lea PJ, Leegood RC (1999). Photorespiratory metabolism of glyoxylate and formate in glycine-accumulating mutants of barley and Amaranthus edulis. Planta, 207(4), 518 - 526. doi:10.1007/s004250050512
    • WINGLER A, QUICK WP, BUNGARD RA, BAILEY KJ, LEA PJ, LEEGOOD RC (1999). The role of photorespiration during drought stress: an analysis utilizing barley mutants with reduced activities of photorespiratory enzymes. Plant, Cell and Environment, 22(4), 361 - 373. doi:10.1046/j.1365-3040.1999.00410.x
    • Wingler A, Walker RP, Chen ZH, Leegood RC (1999). Phosphoenolpyruvate Carboxykinase Is Involved in the Decarboxylation of Aspartate in the Bundle Sheath of Maize. PLANT PHYSIOLOGY, 120(2), 539 - 546. doi:10.1104/pp.120.2.539
    • Wingler A, Ann VJ, Lea PJ, Leegood RC (1999). Short communication. Serine: glyoxylate aminotransferase exerts no control on photosynthesis. Journal of Experimental Botany, 50(334), 719 - 722. doi:10.1093/jexbot/50.334.719


    • Wingler A, von Schaewen A, Leegood RC, Lea PJ, Quick WP (1998). Regulation of Leaf Senescence by Cytokinin, Sugars, and Light . Effects on NADH-Dependent Hydroxypyruvate Reductase. PLANT PHYSIOLOGY, 116(1), 329 - 335. doi:10.1104/pp.116.1.329


    • Hampp R, Wingler A (1997). The role of mycorrhiza. In Foyer CH (Ed.), A Molecular Approach to Primary Metabolism in Higher Plants (pp. - ). : CRC Press.
    • Wingler A, Lea PJ, Leegood RC (1997). Control of photosynthesis in barley plants with reduced activities of glycine decarboxylase. Planta, 202(2), 171 - 178. doi:10.1007/s004250050116


    • Wingler A, Wallenda T, Hampp R (1996). Mycorrhiza formation on Norway spruce (Picea abies) roots affects the pathway of anaplerotic CO2 fixation. Physiologia Plantarum, 96(4), 699 - 705. doi:10.1034/j.1399-3054.1996.960421.x
    • Wallenda T, Schaeffer C, Einig W, Wingler A, Hampp R, Seith B, George E, Marschner H (1996). Effects of varied soil nitrogen supply on Norway spruce (Picea abies [L.] Karst.). II. Carbon metabolism in needles and mycorrhizal roots.. Plant and Soil, 186(2), 361 - 369. doi:10.1007/BF02415531
    • Seith B, George E, Marschner H, Wallenda T, Schaeffer C, Einig W, Wingler A, Hampp R (1996). Effects of varied soil nitrogen supply on Norway spruce (Picea abies [L.] Karst.). I. Shoot and root growth and nutrient uptake. Plant and Soil, 184(2), 291 - 298. doi:10.1007/BF00010458
    • Hampp R, Ecke M, Schaeffer C, Wallenda T, Wingler A, Kottke I, Sundberg B (1996). Axenic mycorrhization of wild type and transgenic hybrid aspen expressing T-DNA indoleacetic acid-biosynthetic genes. Trees, 11(1), 59 - 59. doi:10.1007/s004680050059


    • WINGLER A, EINIG W, SCHAEFFER C, WALLENDA T, HAMPP R, WALLANDER H, NYLUND JE (1994). Influence of different nutrient regimes on the regulation of carbon metabolism in Norway spruce [Picea abies (L.) Karst.] seedlings. New Phytologist, 128(2), 323 - 330. doi:10.1111/j.1469-8137.1994.tb04016.x


    • Wingler A, Guttenberger M, Hampp R (1993). Determination of mannitol in ectomycorrhizal fungi and ectomycorrhizas by enzymatic micro-assays. Mycorrhiza, 3(2), 69 - 73. doi:10.1007/BF00210695