Dr Astrid Wingler

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Personal Profile

Name: Astrid Wingler Email: a.wingler@ucl.ac.uk
Title: Dr Tel: 020 7679 2681
Department: Genetics, Evolution & Environment Fax: 020 7679 7096
Position: Senior Lecturer Address: Darwin Building, University College London, Gower Street, London, WC1E 6BT
Research Domain: Basic Life Sciences Web Page:  

Profile

Research Description

My current research mainly focuses on the role of sugar signalling in plant development (in particular leaf development and senescence) and in the perception of environmental signals. For example, my group exploits natural genetic variation to investigate the genetic basis and molecular mechanisms that regulate leaf senescence. In particular, we investigate how sugar signalling integrates environmental signals, such as nitrogen and carbon supply, light intensity, daylength and temperature. In addition to hexoses, trehalose-6-phosphate has emerged as an important sugar signal in plants and we investigate the mechanisms by which trehalose-6-phosphate signals the availability of carbon. Most of this research is conducted with the model species Arabidopsis, but we also use a perennial relative of Arabidopsis, Arabis alpina, to explore how senescence is regulated by environmental conditions in perennial plants.


Research Activities

Plant Biology

Education Description

I teach a variety of topics in Plant Biology, such as plant physiology and metabolism, environmental biology, plant ecology, genetic engineering, genomic and functional genomic techniques. In addition to my contributions to traditional lecture-based undergraduate courses, my teaching includes the organisation of a field course and lectures to schools and the public.

UCL Collaborators

External Collaborators

Publications

    2013

    • O'Hara LE, Paul MJ, Wingler A (2013). How do sugars regulate plant growth and development? New insight into the role of trehalose-6-phosphate.. Mol Plant, 6(2), 261 - 274. doi:10.1093/mp/sss120

    2012

    • Wingler A, Stangberg EJ, Saxena T, Mistry R (2012). Interactions between temperature and sugars in the regulation of leaf senescence in the perennial herb Arabis alpina L.. J Integr Plant Biol, 54(8), 595 - 605. doi:10.1111/j.1744-7909.2012.01145.x
    • Wingler A, Delatte TL, O'Hara LE, Primavesi LF, Jhurreea D, Paul MJ, Schluepmann H (2012). Trehalose 6-phosphate is required for the onset of leaf senescence associated with high carbon availability.. Plant Physiol, 158(3), 1241 - 1251. doi:10.1104/pp.111.191908
    • Byrne EH, Prosser I, Muttucumaru N, Curtis TY, Wingler A, Powers S, Halford NG (2012). Overexpression of GCN2-type protein kinase in wheat has profound effects on free amino acid concentration and gene expression.. Plant Biotechnol J, 10(3), 328 - 340. doi:10.1111/j.1467-7652.2011.00665.x

    2011

    • Wingler A (2011). Interactions between flowering and senescence regulation and the influence of low temperature in Arabidopsis and crop plants. ANN APPL BIOL, 159(3), 320 - 338. doi:10.1111/j.1744-7348.2011.00497.x

    2010

    • Taylor L, Nunes-Nesi A, Parsley K, Leiss A, Leach G, Coates S, Wingler A, Fernie AR, Hibberd JM (2010). Cytosolic pyruvate,orthophosphate dikinase functions in nitrogen remobilisation during leaf senescence and limits individual seed growth and nitrogen content. Plant Journal, 62, 641 - 652. doi:10.1111/j.1365-313X.2010.04179.x
    • Wingler A, Purdy SJ, Edwards SA, Chardon F, Masclaux-Daubresse C (2010). QTL analysis for sugar-regulated leaf senescence supports flowering-dependent and independent senescence pathways.. New Phytologist, 185(2), 420 - 433.
    • Paul M, Jhurreea D, Zhang Y, Primavesi L, Delatte T, Schluepmann H, Wingler A (2010). Up-regulation of biosynthetic processes associated with growth by trehalose 6-phosphate. Plant Signaling and Behaviour, 5(4), 1 - 7.

    2009

    • Zhang Y, Primavesi LF, Jhurreea D, Andralojc PJ, Mitchell RAC, Powers SJ, Schluepmann H, Delatte T, Wingler A, Paul MJ (2009). Inhibition of Snf1-related protein kinase (SnRK1) activity and regulation of metabolic pathways by trehalose 6-phosphate.. Plant Physiology, 149(4), 1860 - 1871.
    • Wingler A, Masclaux-Daubresse C, Fischer AM (2009). Sugars, senescence, and ageing in plants and heterotrophic organisms. Journal of Experimental Botany, 60(60), 1063 - 1066. doi:10.1093/jxb/erp067

    2008

    • Paul M, Jhurreea D, Primavesi L, Zhang Y, Sivagnanam I, Wingler A (2008). Integration of leaf metabolism and physiology by the trehalose pathway. doi:10.1016/j.cbpa.2008.04.538
    • Byrne E, Wingler A, Muttucumaru N, Halford N (2008). The wheat GCN2 signalling pathway: Does this kinase play an important role in stress signalling?. doi:10.1016/j.cbpa.2008.04.410
    • Wingler A, Roitsch T (2008). Metabolic regulation of leaf senescence: interactions of sugar signalling with biotic and abiotic stress responses. Plant Biology, 10(S1), 50 - 62.
    • Byrne E, Muttucumaru N, Wingler A, Halford N (2008). The wheat GCN2 signalling pathway: Does this kinase play an important role in stress signalling?. doi:10.1016/j.cbpa.2008.04.521
    • Wingler A, Purdy S, Chardon F, Masclaux-Daubresse C (2008). Genetic basis of the link between senescence regulation and flowering time control. doi:10.1016/j.cbpa.2008.04.510

    2007

    • Wingler A (2007). Transcriptional or post-transcriptional regulation - how does a plant know when to senesce? Third European workshop on plant senescence, Salzau, Germany, February 2007. NEW PHYTOL, 175(1), 7 - 9.
    • Masclaux-Daubresse C, Purdy S, Lemaitre T, Pourtau N, Taconnat L, Renou J-P, Wingler A (2007). Genetic variation suggests interaction between cold acclimation and metabolic regulation of leaf senescence. Plant Physiology, 143(1), 434 - 446. doi:10.1104/pp.106.091355
    • Wingler A (2007). Transcriptional or post-transcriptional regulation – how does a plant know when to senesce?. New Phytologist, 175(1), 7 - 9. doi:10.1111/j.1469-8137.2007.02106.x

    2006

    • Wingler A, Purdy S, MacLean JA, Pourtau N (2006). The role of sugars in integrating environmental signals during the regulation of leaf senescence. Journal of Experimental Botany, 57(2), 391 - 399. doi:10.1093/jxb/eri279
    • Pourtau N, Jennings R, Pelzer E, Pallas J, Wingler A (2006). Effect of sugar-induced senescence on gene expression and implications for the regulation of senescence in Arabidopsis. Planta, 224(3), 556 - 568. doi:10.1007/s00425-006-0243-y

    2005

    • Wingler A, Brownhill E, Pourtau N (2005). Mechanisms of the light-dependent induction of cell death in tobacco plants with delayed senescence. Journal of Experimental Botany, 56(421), 2897 - 2905. doi:10.1093/jxb/eri284
    • Levey S, Wingler A (2005). Natural variation in the regulation of leaf senescence and relation to other traits in Arabidopsis. Plant, Cell and Environment, 28(2), 223 - 231. doi:10.1111/j.1365-3040.2004.01266.x
    • Diaz C, Purdy S, Christ A, Morot-Gaudry JF, Wingler A, Masclaux-Daubresse C (2005). Characterization of Markers to Determine the Extent and Variability of Leaf Senescence in Arabidopsis. A Metabolic Profiling Approach.. Plant Physiology, 138(2), 898 - 908. doi:10.1104/pp.105.060764

    2004

    • Wingler A, Mares M, Pourtau N (2004). Spatial patterns and metabolic regulation of photosynthetic parameters during leaf senescence.. New Phytologist, 161(3), 781 - 789. doi:10.1111/j.1469-8137.2004.00996.x
    • Pourtau N, Mares M, Purdy S, Quentin N, Ruel A, Wingler A (2004). Interactions of abscisic acid and sugar signalling in the regulation of leaf senescence.. Planta, 219(5), 765 - 772. doi:10.1007/s00425-004-1279-5
    • Kasinathan V, Wingler A (2004). Effect of reduced arginine decarboxylase activity on salt tolerance and on polyamine formation during salt stress in Arabidopsis thaliana.. Physiologia Plantarum, 121(1), 101 - 107. doi:10.1111/j.0031-9317.2004.00309.x
    • Wingler A, Mares M, Pourtau N (2004). Spatial patterns and metabolic regulation of photosynthetic parameters during leaf senescence. NEW PHYTOL, 161(3), 781 - 789. doi:10.1111/j.1469-8137.2003.00996.x

    2002

    • Brodmann D, Schuller A, Ludwig-Muller J, Aeschbacher RA, Wiemken A, Boller T, Wingler A (2002). Induction of trehalase in Arabadopsis plants infected with the trehalase-producing pathogen Plasmodiophora brassicae. Molecular Plant-Microbe Interactions, 15(7), 693 - 700.
    • Wingler A (2002). The function of trehalose biosynthesis in plants. Phytochemistry, (5), 437 - 550.

    2001

    • Vogel G, Fiehn O, Jean-Richard-dit-Bressel L, Boller T, Wiemken A, Aeschbacher RA, Wingler A (2001). Trehalose metabolism in Arabidopsis: Occurrence of trehalose and molecular cloning and characterisation of trehalose-6-phosphate synthase homologues. Journal of Experimental Botany, 52(362), 1817 - 1826.
    • Fritzius T, Aeschbacher RA, Wiemken A, Wingler A (2001). Induction of ApL3 expression by trehalose complements the starch-deficient Arabidopsis mutant adg2-1 lacking ApL1, the large subunit of ADP-glucose pyrophosphorylase. Plant Physiology, 126(2), 883 - 889. doi:10.1104/pp.126.2.883
    • Muller J, Aeschbacher RA, Wingler A, Boller T, Wiemken A (2001). Trehalose and trehalase in Arabidopsis. Plant Physiology, 125(2), 1086 - 1093.

    2000

    • Wingler A, Lea PJ, Quick WP, Leegood RC (2000). Photorespiration - metabolic pathways and their role in stress protection. Philosophical Transactions of the Royal Society B: Biological Sciences, 355, 1517 - 1529.
    • Chen ZH, Walker RP, Acheson RM, T'csi LI, Wingler A, Lea PJ, Leegood RC (2000). Are isocitrate lyase and phosphoenolpyruvate carboxykinase involved in gluconeogenesis during senescence of barley leaves and cucumber cotyledons?. Plant and Cell Physiology, 41, 960 - 967.
    • Wingler A, Fritzius T, Wiemken A, Boller T, Aeschbacher RA (2000). Trehalose induces the ADP-glucose pyrophosphorylase gene, ApL3, and starch synthesis in Arabidopsis. Plant Physiology, 124, 105 - 114.